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asbestosis treatment

Leona M Dowman, Christine F McDonald, Catherine J Hill, Annemarie L Lee, Kathryn Barker, Claire Boote, Ian Glaspole, Nicole S L Goh, Anne M Southcott, Angela T Burge, Rebecca Gillies, Alicia Martin, Anne E Holland
BACKGROUND: Uncertainty exists regarding the clinical relevance of exercise training across the range of interstitial lung diseases (ILDs). OBJECTIVE: To establish the impact of exercise training in patients with ILDs of differing aetiology and severity. METHODS: 142 participants with ILD (61 idiopathic pulmonary fibrosis (IPF), 22 asbestosis, 23 connective tissue disease-related ILD (CTD-ILD) and 36 with other aetiologies) were randomised to either 8 weeks of supervised exercise training or usual care...
February 17, 2017: Thorax
Beata Świątkowska, Neonila Szeszenia-Dąbrowska, Urszula Wilczyńska
In Poland, the use of asbestos was banned in 1997 and asbestos plants have been closed since then. Despite their closure, cases of asbestos-related occupational diseases among former asbestos workers are still being recorded in the Central Register of Occupational Diseases. Between 2001 and 2014, there were 2726 asbestos-related illnesses, classified and reported as diseases associated with occupational exposure to asbestos. In 2000, Poland introduced a programme called Amiantus, targeted at former asbestos-processing plant workers...
August 1, 2016: Bulletin of the World Health Organization
Pedro Bullón, Jose Manuel Navarro
Endometriosis remains a challenging condition for clinicians to treat. To improve our results we have to develop new treatment strategies based on pathophysiological mechanisms targeting the etiologic and pathogenic processes involved. It is essential to understand the inflammatory reaction and immunity incorporating the new molecular concepts. Inflammasome has been described as a multiprotein complex and is considered a key regulator of the innate and adaptive host response that surveys the cytosol and other compartments into the cell...
July 8, 2016: Current Drug Targets
Joseph P Lynch, Richard H Huynh, Michael C Fishbein, Rajan Saggar, John A Belperio, S Sam Weigt
Idiopathic pulmonary fibrosis (IPF) is a specific form of chronic interstitial lung pneumonia associated with the histologic pattern of usual interstitial pneumonia (UIP). Although UIP is a distinct histologic lesion, this histologic pattern is not specific for IPF and can also be found in other diseases (e.g., connective tissue disease and asbestosis). Clinical features of IPF include progressive cough, dyspnea, restrictive ventilatory defect, and progressive fibrosis and destruction of the lung parenchyma...
June 2016: Seminars in Respiratory and Critical Care Medicine
P P Song, Y Wang, J L Sun, Y Gao, J Liu, Y X Chen
OBJECTIVE: It can provide statistics reference for the prevention and treatment by analysising the status and characteristics related to the asbestos disease of an asbestos products enterprises from 1988 to 2014. METHODS: We have collected the data concerning the case of asbestos-related disease between 1988 and 2014, then the data were arranged, collecteted and analyzed using statistical method. RESULTS: The total of patients is 625 (male: 225, female: 400)...
March 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
Beatriz Araujo Cortez, Paula Rezende-Teixeira, Sambra Redick, Stephen Doxsey, Glaucia Maria Machado-Santelli
Chrysotile, like other types of asbestos, has been associated with mesothelioma, lung cancer and asbestosis. However, the cellular abnormalities induced by these fibers involved in cancer development have not been elucidated yet. Previous works show that chrysotile fibers induce features of cancer cells, such as aneuploidy, multinucleation and multipolar mitosis. In the present study, normal and cancer derived human cell lines were treated with chrysotile and the cellular and molecular mechanisms related to generation of aneuploid cells was elucidated...
February 23, 2016: Oncotarget
(no author information available yet)
The Collegium Ramazzini reaffirms its long-standing position that responsible public health action is to ban all extraction and use of asbestos, including chrysotile. This current statement updates the Collegium's earlier statements with a focus on global health dimensions of asbestos and asbestos-related diseases (ARD). The ARD epidemic will likely not peak for at least a decade in most industrialized countries and for several decades in industrializing countries. Asbestos and ARD will continue to present challenges in the arena of occupational medicine and public health, as well as in clinical research and practice, and have thus emerged as a global health issue...
January 2016: Scandinavian Journal of Work, Environment & Health
Leon Bacchus, Rakesh D Shah, Jonathan H Chung, Traves P Crabtree, Darel E Heitkamp, Mark D Iannettoni, Geoffrey B Johnson, Clinton Jokerst, Barbara L McComb, Anthony G Saleh, Robert M Steiner, Tan-Lucien H Mohammed, James G Ravenel
Occupational lung disease is a category of disease entities characterized by a reaction of the lung parenchyma to inhaled aerosolized particles found in the environment. This document summarizes the imaging appropriateness data for silicosis, coal worker pneumoconiosis, and asbestosis. The main points of the document are that computed tomography is more sensitive than radiography, computed tomography without contrast generally suffices for evaluation, and fluorodeoxyglucose-positron emission tomography may have utility in patients with mesothelioma...
January 2016: Journal of Thoracic Imaging
Yan Liang, Yan Wang, Songquan Zhang, Juan Liu, Yanxia Chen
OBJECTIVE: To discuss the clinical characteristics, diagnosis and treatment of the clinical characteristics and prognosis of asbestosis complicated with malignant mesothelioma patients. METHODS: In 3 cases of asbestosis complicated with malignant mesothelioma were retrospectively analyzed. RESULTS: In the 3 patients, 2 cases of pleural mesothelioma, with chest tightness, chest and back pain as initial symptom; 1 case of peritoneal mesothelioma, with abdominal distention, abdominal pain, dysuria as initial symptom...
May 2015: Chinese Journal of Industrial Hygiene and Occupational Diseases
Marita T Dale, Zoe J McKeough, Thierry Troosters, Peter Bye, Jennifer A Alison
BACKGROUND: Non-malignant dust-related respiratory diseases, such as asbestosis and silicosis, are similar to other chronic respiratory diseases and may be characterised by breathlessness, reduced exercise capacity and reduced health-related quality of life. Some non-malignant dust-related respiratory diseases are a global health issue and very few treatment options, including pharmacological, are available. Therefore, examining the role of exercise training is particularly important to determine whether exercise training is an effective treatment option in non-malignant dust-related respiratory diseases...
2015: Cochrane Database of Systematic Reviews
Irena Manfredo
Unemployed persons are often on the margins of the healthcare system and under the radar of safety and health organisations, as no systematic records are kept of occupational diseases caused by exposure at previous work place. Law in Slovenia requires that asbestos-related occupational diseases are verified by establishing the causal relationship between exposure at work and its effect on the worker. This report describes a case of verifying occupational pleural disease in an unemployed carpenter who was referred for consultation with occupational health specialist as part of the regular procedure for the unemployed registered at the Employment Service of Slovenia...
September 1, 2015: Arhiv za Higijenu Rada i Toksikologiju
Laura Niccoli, Emanuele Cassarà, Olga Kaloudi, Carlotta Nannini, Micaela Romagnoli, Fabrizio Cantini
BACKGROUND: Asbestosis is characterized by lung and pleural fibrosis and by immune system dysregulation, with autoantibody production and systemic immune-mediated disease. No specific therapies are available for asbestosis. Recently, the pivotal pathogenic role exerted by interleukin-1beta has been recently reported. CASE PRESENTATION: We treated with anti-interleukin 1 beta targeted antibody canakinumab a 67 year old man with asbestosis and long lasting systemic autoimmune features...
June 14, 2015: BMC Musculoskeletal Disorders
Marcus Oldenburg, Volker Harth, Ulf Manuwald
BACKGROUND: This study estimated the discharge diagnosis due to non-cancer diseases of German seamen employed on German vessels in comparison to the general German male population. MATERIALS AND METHODS: In a database, the German health insurance company for seafarers determined the discharge diagnoses from hospital for all German seafarers. In the time period from January 1997 to December 2007, this database encompassed on average more than 21,000 German seamen per year...
2015: International Maritime Health
Basilua Andre Muzembo, Yoji Deguchi, Nlandu Roger Ngatu, Masamitsu Eitoku, Ryoji Hirota, Narufumi Suganuma
Individuals exposed to fibrogenic mineral dust may exhibit an impaired antioxidant system and produce high levels of reactive oxygen and nitrogen species through immune cells, contributing to the perturbation of immune cell function, inflammation, fibrosis and lung cancer. The lung diseases which are caused by inhalation of fibrogenic mineral dust, known as pneumoconioses, develop progressively and irreversibly over decades. At the moment there is no known cure. The trace element selenium has potent antioxidant and anti-inflammatory properties mediated mainly through selenoproteins...
April 2015: Environment International
Abdulmonam Ali, Sri Krishna Chaitanya Arudra, Sarthi Shah, Vasuki Anandan, Ragheb Assaly
SESSION TITLE: Pulmonary Vascular Disease Student/Resident Case Report Posters ISESSION TYPE: Medical Student/Resident Case ReportPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: The accurate etiology of pulmonary arterial hypertension (PAH) can be challenging and misleading on the basis of clinical grounds alone. Here we present a unique case of severe PAH with unexpected findings on autopsy.CASE PRESENTATION: A 73 year-old man known to have history of heavy exposure to asbestos...
October 1, 2014: Chest
Umang Shah, Dr Arpan Shah, Dr Chandrakant Shah, Dr Vihang Shah, Dr Apurva Vaidya
SESSION TITLE: Cardiothoracic Surgery PostersSESSION TYPE: Original Investigation PosterPRESENTED ON: Wednesday, October 29, 2014 at 01:30 PM - 02:30 PMPURPOSE: A 45 year old laborer, chronic smoker (10 bidis/day), non-diabetic, non-hypertensive presented to the emergency department with a 3 month h/o progressive breathlessness, right side chest pain, cough with expectoration and low grade fever, sleeping towards right side. No h/o hemoptysis or weight loss. He was presumptively started on anti-tuberculosis treatment based on his chest x ray findings...
October 1, 2014: Chest
Mutlay Sayan, Arti Shukla, Maximilian B MacPherson, Sherrill L Macura, Jedd M Hillegass, Timothy N Perkins, Joyce K Thompson, Stacie L Beuschel, Jill M Miller, Brooke T Mossman
Malignant mesothelioma (MM), lung cancers, and asbestosis are hyperproliferative diseases associated with exposures to asbestos. All have a poor prognosis; thus, the need to develop novel and effective therapies is urgent. Vandetanib (Van) (ZD6474, ZACTIMA) is a tyrosine kinase inhibitor that has shown equivocal results in clinical trials for advanced non-small cell lung cancer. However, tyrosine kinase inhibitors alone have shown no significant clinical activity in phase II trials of patients with unresectable MM...
November 2014: American Journal of Respiratory Cell and Molecular Biology
Ahmet Sezer, Ahmet Taner Sümbül, Hüseyin Abalı, Hüseyin Mertsoylu, Ozgür Ozyılkan
BACKGROUND: Malignant pleural mesothelioma is a rare lethal malignancy caused by asbestos exposure. It is more frequently seen in certain regions in Turkey. In this retrospective study, we aimed to analyse demographic, clinical, and pathological data and treatment-related features in 54 patients. MATERIAL AND METHODS: The study included 54 patients diagnosed with malignant mesothelioma that were followed and treated. RESULT: Of the 54 patients, 34 (55...
2014: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Takeshi Kurihara, Daigo Kawano, Tatsuro Okamoto, Takatoshi Fujishita, Yuzo Suzuki, Hirokazu Kitahara, Shinichiro Shimamatsu, Mikihiro Kouno, Yousuke Morodomi, Yoshihiko Maehara
A 71-year-old male with a history of asbestosis was referred to our department for the treatment of a bilateral pneumothorax. His pulmonary function was severely impaired because of asbestosis and emphysema. Chest computed tomography showed severe emphysema with bilateral multiple bullae. Although chest drainage tubes were placed in the bilateral thorax, the left lung did not completely expand due to a persistent air leak. We performed VATS while retaining the patient's spontaneous respiration under general sedation with regional epidural anesthesia, since one-lung, positive pressure ventilation was considered to be difficult to achieve...
January 2014: Fukuoka Igaku Zasshi, Hukuoka Acta Medica
J Rastrick, M Birrell
Fibrotic respiratory diseases severely disrupt lung function and currently have an extremely poor prognosis. This is attributable to the limited amount of treatment options available, in part due to our lack of understanding of the mechanisms driving disease pathogenesis. Although the majority of cases appear to be idiopathic, a number of factors are known to cause pulmonary fibrosis, such as the inhalation of silica crystals (silicosis), asbestos fibers (asbestosis) and certain drugs such as bleomycin. Evidence suggests that the inhalation of such substances can induce the formation of the NLRP3 inflammasome; a multimeric protein complex responsible for the activation of caspase-1 and maturation of the proinflammatory cytokines IL-1b and IL-18...
February 2014: Minerva Medica
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