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Haichao Lan, Fei Liang, Xingxing Jiang, Cong Zhang, Haohai Yu, Zheshuai Lin, Huaijin Zhang, Jiyang Wang, Yicheng Wu
Mid-infrared (mid-IR) coherent light is crucial for several applications in science as well as daily life, and its development especially in powerful augmentation is constrained by the availability of nonlinear optical (NLO) materials. The development of useful mid-IR NLO materials is limited by the requirements of a wide mid-IR transparent window, high laser damaged threshold (LDT), and strong NLO effect. It is common knowledge that oxides are not suitable mid-IR NLO materials, as their IR absorption cutoff wavelengths are usually less than 6 μm; however, their LDTs and NLO effects can be large...
February 19, 2018: Journal of the American Chemical Society
Tara E Holm Atkins, Malin C Öhman, Mikkel Brabrand
INTRODUCTION: Early warning scores (EWS) have been developed to identify the degree of illness severity among acutely ill patients. One system, The Laboratory Decision Tree Early Warning Score (LDT-EWS) is wholly laboratory data based. Laboratory data was used in the development of a rare computerized method, developing a decision tree analysis. This article externally validates LDT-EWS, which is obligatory for an EWS before clinical use. METHOD: We conducted a retrospective review of prospectively collected data based on a time limited sample of all patients admitted through the medical admission unit (MAU) on a Danish secondary hospital...
February 13, 2018: European Journal of Internal Medicine
A A Megahed, M W H Hiew, P D Constable
BACKGROUND: Plasma fructosamine concentration ([FRA]) is a widely used long term hyperglycemic biomarker in humans and dogs, but its clinical usefulness as a hypoglycemic biomarker in dairy cattle is uncertain. OBJECTIVES: To evaluate the relationship between plasma [FRA] and glucose concentration ([gluc]) as well as indices of energy balance during early lactation in dairy cattle, and to characterize the influence of plasma total protein concentration ([TP]) and albumin concentration ([albumin]) on [FRA]...
February 9, 2018: Journal of Veterinary Internal Medicine
Qing Ye, Jun Cheng, Wangbiao Guo, Junchen Xu, Ke Li, Junhu Zhou
A novel serial lantern-shaped draft tube (LDT) that generates vortices is proposed to increase radial velocity between dark and light regions for improving CO2 fixation with microalgae in a gas-lift circumflux column (GCC) photobioreactor. Clockwise vortices are generated in the downflow outerloop of the GCC photobioreactor with LDT. Radial velocity was improved from 1.50 to 4.35 × 10-2 m/s, thereby decreased liquid cycle period between dark and light regions by 1.9 times. Mixing time decreased by 21%, and mass transfer coefficient increased by 26% with LDT...
January 31, 2018: Bioresource Technology
Marius Ilie, Jonathan Juco, Lingkang Huang, Veronique Hofman, Shirin Khambata-Ford, Paul Hofman
BACKGROUND: Pembrolizumab monotherapy is a standard-of-care treatment for the first- and second-line treatment of advanced non-small cell lung cancer with programmed death ligand 1 (PD-L1) tumor proportion score (TPS) values ≥ 50% and ≥ 1%, respectively. PD-L1 testing with the PD-L1 immunohistochemistry (IHC) 22C3 pharmDx companion assay has been validated on tumor tissue with the Dako Autostainer Link 48 (ASL48). 22C3 anti-PD-L1 antibody-based laboratory-developed tests (LDTs) compatible with other autostainers and cytology samples are essential to support pembrolizumab treatment decisions across institutions globally...
February 7, 2018: Cancer Cytopathology
Alexandra S Cross, E Helen Kemp, Anne White, Leanne Walker, Suzanne Meredith, Pooja Sachdev, Nils P Krone, Richard J Ross, Neil P Wright, Charlotte J Elder
OBJECTIVE: The short synacthen test (SST) is widely used to assess patients for adrenal insufficiency but the frequency and protocols used across different centres for the low-dose test (LDT) are unknown. This study aimed to survey centres and test the accuracy of ten different synacthen preparation strategies used for the LDT. METHODS: Members of six international endocrine societies were surveyed regarding diagnostic tests used for adrenal insufficiency, and in particular the SST...
February 2, 2018: Clinical Endocrinology
Jean Kany, Jean Grimberg, Rajkumar S Amaravathi, Padmanaban Sekaran, Dan Scorpie, Jean David Werthel
PURPOSE: The main objective of this retrospective study was to analyze the rate and modes of failure of latissimus dorsi transfer (LDT). The secondary objective was to evaluate whether a rupture of the transfer was associated with a worse outcome. METHODS: During a 2-year period, we performed consecutive LDTs either for irreparable posterior-superior rotator cuff tears (RCTs) or for failed prior repair. All the LDTs were performed by a single surgeon. All transfers were arthroscopically assisted and fixed as a tubularized LD tendon in a bone tunnel inside the humeral head...
January 17, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
J Adam, N Le Stang, I Rouquette, A Cazes, C Badoual, H Pinot-Roussel, L Tixier, C Danel, F Damiola, D Damotte, F Penault-Llorca, S Lantuéjoul
Background: Various PD-L1 immunohistochemistry (IHC) assays have been developed and used in clinical trials in association with different drugs. In order to harmonize and make PD-L1 testing in non-small cell lung cancer (NSCLC) widely available, we conducted a multicenter study comparing PD-L1 standardized assays and laboratory-developed tests (LDT). Methods: IHC with five anti-PD-L1 monoclonal antibodies (28-8, 22C3, E1L3N, SP142 and SP263) was performed concomitantly on 41 NSCLC surgical specimens in 7 centers using Dako Autostainer Link 48 (3 centers), Leica Bond (2 centers) or Ventana BenchMark Ultra (2 centers), platforms...
January 16, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Xiaocong Chen, Yanping Dong, Xiufen Yu
The predictive validity of various corpus-based frequency norms in first-language lexical processing has been intensively investigated in previous research, but less attention has been paid to this issue in second-language (L2) processing. To bridge the gap, in the present study we took English as a case in point and compared the predictive power of a large set of corpus-based frequency norms for the performance of an L2 English visual lexical decision task (LDT). Our results showed that, in general, the frequency norms from SUBTLEX-US and WorldLex-Blog tended to predict L2 performance better in reaction times, whereas the frequency norms from corpora with a mixture of written and spoken genres (CELEX, WorldLex-Blog, BNC, ANC, and COCA) tended to predict L2 accuracy better...
January 16, 2018: Behavior Research Methods
Xiaoxiao Wang, Xingxing Jiang, Hongming Liu, Lei Yang, Zheshuai Lin, Zhanggui Hu, Xianggao Meng, Xingguo Chen, Jingui Qin
Using an ion-substitution strategy, herein, a new polar material, Pb3(SeO3)Br4, with a greatly enhanced SHG response has been successfully designed and synthesized through a hydrothermal reaction. Pb3(SeO3)Br4 crystallizes in the NCS space group P212121 and consists of a three-dimensional framework formed by interconnecting one-dimensional chains, with a good thermal stability up to 230 °C. This compound exhibits a phase-matchable SHG response as strong as that of KH2PO4 (KDP) and a relatively wide mid-infrared (mid-IR) transparent window...
January 17, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Juan Haro, Pilar Ferré
It is not clear whether multiple unrelated meanings inhibit or facilitate word recognition. Some studies have found a disadvantage for words having multiple meanings with respect to unambiguous words in lexical decision tasks (LDT), whereas several others have shown a facilitation for such words. In the present study, we argue that these inconsistent findings may be due to the approach employed to select ambiguous words across studies. To address this issue, we conducted three LDT experiments in which we varied the measure used to classify ambiguous and unambiguous words...
December 26, 2017: Journal of Psycholinguistic Research
Annette S Kim, Angela N Bartley, Julia A Bridge, Suzanne Kamel-Reid, Alexander J Lazar, Neal I Lindeman, Thomas A Long, Jason D Merker, Alex J Rai, David L Rimm, Paul G Rothberg, Patricia Vasalos, Joel T Moncur
Importance: The debate about the role of the Food and Drug Administration (FDA) in the regulation of laboratory-developed tests (LDTs) has focused attention on the analytical performance of all clinical laboratory testing. This study provides data comparing the performance of LDTs and FDA-approved companion diagnostics (FDA-CDs) in proficiency testing (PT) provided by the College of American Pathologists Molecular Oncology Committee. Objective: To compare the analytical performance of LDTs and FDA-CDs on well-characterized PT samples and to compare the practice characteristics of laboratories using these assays...
December 14, 2017: JAMA Oncology
Anneloes L van Rijn, Roel H T Nijhuis, Vincent Bekker, Geert H Groeneveld, Els Wessels, Mariet C W Feltkamp, Eric C J Claas
Rapid diagnosis of respiratory infections is of great importance for adequate isolation and treatment. Due to the batch-wise testing, laboratory-developed real-time polymerase chain reaction (PCR) assays (LDT) often result in a time to result of one day. Here, LDT was compared with rapid ePlex® Respiratory Pathogen (RP) Panel testing of GenMark Diagnostics (Carlsbad, CA, USA) with regard to time to result, installed isolation precautions, and antibacterial/antiviral treatment. Between January and March 2017, 68 specimens of 64 patients suspected of an acute respiratory infection were tested with LDT and the ePlex® RP panel...
December 8, 2017: European Journal of Clinical Microbiology & Infectious Diseases
Megala Narasingam, Kamini Vijeepallam, Zahurin Mohamed, Vijayapandi Pandy
This study presents anxiolytic- and antidepressant-like effects of a methanolic extract of Morinda citrifolia Linn. (noni) fruit (MMC) in well-established mouse models of anxiety and depression. The administration of MMC (1 g/kg, p.o.) and diazepam (1 mg/kg, i.p.) significantly attenuated anxiety-like behaviour in mice by increasing the percentage of time spent and number of entries in the open arms in the elevated plus maze (EPM), and significantly enhanced the exploration in the light box in the light/dark test (LDT)...
December 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Jie Chen, Detian Li
Renal fibrosis yields decreased renal function and is a potent contributor to chronic kidney disease (CKD). Telbivudine (LdT) is an anti-hepatitis B virus (HBV) drug that has been found to steadily improve renal function, but the mechanism of drug action is unclear. One explanation is that LdT impacts inflammatory or fibrotic pathways. In this study, we investigated renal protection by LdT in a rat model of unilateral ureteral obstruction (UUO). UUO rats received oral gavage of LdT (1, 1.5, or 2g/kg/day) for 5weeks...
December 2, 2017: International Immunopharmacology
Marre W Kaandorp, Cas Smits, Paul Merkus, Joost M Festen, S Theo Goverts
Not all of the variance in speech-recognition performance of cochlear implant (CI) users can be explained by biographic and auditory factors. In normal-hearing listeners, linguistic and cognitive factors determine most of speech-in-noise performance. The current study explored specifically the influence of visually measured lexical-access ability compared with other cognitive factors on speech recognition of 24 postlingually deafened CI users. Speech-recognition performance was measured with monosyllables in quiet (consonant-vowel-consonant [CVC]), sentences-in-noise (SIN), and digit-triplets in noise (DIN)...
January 2017: Trends in Hearing
Flávio Augusto Sanches Politi, Amauri Alves Souza, Rafaela Regina Fantatto, Rosemeire Cristina Linhari Rodrigues Pietro, Waldomiro Barioni, Márcio Dias Rabelo, Humberto Ribeiro Bizzo, Ana Carolina de Souza Chagas, Maysa Furlan
Sheep breeding has suffered economic losses due to parasitism by gastrointestinal nematodes, particularly Haemonchus contortus. The use of natural products, specifically Tagetes patula, has been suggested as an alternative method of combatting this issue. Chemical analyses of the extracts of this species described in the literature report the presence of important classes of secondary metabolites such as thiophenes, flavonoids, alkaloids and benzofurans, some of which were identified and isolated in this study...
November 27, 2017: Chemistry & Biodiversity
Jessica Maria Leite Dos Santos, Janaelia Ferreira Vasconcelos, Gracielle Araújo Frota, Wesley Lyeverton Correia Ribeiro, Weibson Paz Pinheiro André, Luiz da Silva Vieira, Marcel Teixeira, Claudia Maria Leal Bevilaqua, Jomar Patrício Monteiro
Parasitism by Haemonchus contortus is one of the main limiting factors in small ruminant production in tropical areas. Benzimidazoles (BZ) and macrocyclic lactones (ML) are the most used anthelmintic classes in gastrointestinal nematodes control. There is considerable scientific evidence of a possible relation between the anthelmintic resistance to BZ and ML. This study aimed to characterize the dynamics of anthelmintic resistance in an H. contortus susceptible isolate under selection pressure for BZ and ML alone or in combination and the role of isotype 1 β-tubulin gene SNPs in these situations...
December 15, 2017: Veterinary Parasitology
B D Hedley, G Cheng, J Luider, W Kern, G Lozanski, I Chin-Yee, L E Lowes, M Keeney, D Careaga, R Magari, L Tejidor
INTRODUCTION: Flow cytometric immunophenotyping (FCI) is an integral part in the diagnosis and classification of hematologic malignancies. FCI results also influence therapeutic decisions and disease prognosis. ClearLLab LS is a 12-antibody 10-color cocktail provided in dry format designed as a screen for patients suspected of having hematolymphoid disease. METHODS: A blinded comparison between ClearLLab LS, (CD8-FITC,Kappa-FITC,CD4-PE,Lambda-PE,CD19-ECD,CD56-PE-Cy5...
November 24, 2017: Cytometry. Part B, Clinical Cytometry
Chengyu Li, Alexander A Farag, Guillermo Maza, Sam McGhee, Michael A Ciccone, Bhakthi Deshpande, Edmund A Pribitkin, Bradley A Otto, Kai Zhao
BACKGROUND: Abnormal nasal aerodynamics or trigeminal functions have been frequently implicated in the symptomology of empty nose syndrome (ENS), yet with limited evidence. METHODS: Individual computed tomography (CT)-based computational fluid dynamics (CFD) was applied to 27 ENS patients to simulate their nasal aerodynamics and compared with 42 healthy controls. Patients' symptoms were confirmed with Empty Nose Syndrome 6-item Questionnaire (ENS6Q), 22-item Sino-Nasal Outcome Test (SNOT-22), and Nasal Obstruction Symptom Evaluation (NOSE) scores...
November 22, 2017: International Forum of Allergy & Rhinology
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