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https://www.readbyqxmd.com/read/29663444/transitioning-cytomegalovirus-viral-load-testing-from-a-laboratory-developed-test-to-the-cobas%C3%A2-cmv-quantitative-nucleic-acid-assay
#1
Michael Payne, Linda Merrick, Tanya Lawson, Gordon Ritchie, Christopher Lowe
Commutability between human cytomegalovirus (CMV) viral load assays (VLA) is poor, despite the development of a WHO CMV International Standard (CMV IS). We evaluated a new CMV VLA, cobas® CMV, as compared to our current laboratory developed CMV VLA (LDT), for clinical use. Both the LDT and cobas® CMV were run in parallel for 109 patient samples. In addition, 104 replicates, over 8 dilutions, of the CMV IS were tested. Conversion factors and correlation between the two assays were calculated. The correlation coefficient between the LDT and cobas® CMV was 0...
April 16, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29656993/anthelmintic-resistance-in-goat-herds-in-vivo-versus-in-vitro-detection-methods
#2
M Babják, A Königová, M Urda Dolinská, J Vadlejch, M Várady
Anthelmintic resistance (AR) is a serious threat to animal health and has a major economic impact worldwide due to production and financial losses. The aim of this study was to determine the occurrence of AR on 30 goat farms in Slovakia during the pasturing seasons and to compare three widely used in vitro and in vivo methods for detecting AR in field conditions. A three-year survey was conducted during the pasturing seasons of 2014-2016. Goats on each farm were split into treated and control groups and were treated by recommended (5 mg/kg body weight) and double doses (10 mg/kg b...
April 30, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29611400/real-world-experience-of-telbivudine-versus-entecavir-in-patients-with-chronic-hepatitis-b-including-long-term-outcomes-after-treatment-modification
#3
Jong Won Choi, Se Hyun Kim, Jeong Hun Seo, Yong Suk Cho, Sun Young Won, Byung Kyu Park, Han Ho Jeon, Yong Kang Lee, Chun Kyon Lee
PURPOSE: To estimate long-term outcomes after treatment modification in patients with chronic hepatitis B (CHB) treated with entecavir (ETV) and telbivudine (LdT). MATERIALS AND METHODS: The study enrolled 131 nucleos(t)ide analogue (NA)-naïve CHB patients treated with ETV or LdT. During the 3-year study, NA treatment history including the incidence, the type of treatment modification, reasons for the modification, and overall complete virologic response (CVR) rate were retrospectively evaluated using the patients' medical records...
May 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29601108/synthesis-of-avibactam-derivatives-and-activity-on-%C3%AE-lactamases-and-peptidoglycan-biosynthesis-enzymes-of-mycobacteria
#4
Zainab Edoo, Laura Iannazzo, Fabrice Compain, Inès Li de la Sierra Gallay, Herman van Tilbeurgh, Matthieu Fonvielle, Flavie Bouchet, Eva Le Run, Jean-Luc Mainardi, Michel Arthur, Mélanie Ethève-Quelquejeu, Jean-Emmanuel Hugonnet
There is a renewed interest for β-lactams for treating infections due to Mycobacterium tuberculosis and M. abscessus since their β-lactamases are inhibited by classical (clavulanate) or new generation (avibactam) inhibitors, respectively. Here, we report access to an azido derivative of the diazabicyclooctane (DBO) scaffold of avibactam for functionalization by the Huisgen-Sharpless cycloaddition reaction. The amoxicillin-DBO combinations were active indicating that the triazole ring is compatible with drug penetration (minimal inhibitory concentration of 16 µg/ml for both species)...
March 30, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29599676/cross-sensitization-to-artemisia-and-ambrosia-pollen-allergens-in-an-area-located-outside-of-the-current-distribution-range-of-ambrosia
#5
Łukasz Grewling, Dorota Jenerowicz, Paweł Bogawski, Matt Smith, Małgorzata Nowak, Agata Frątczak, Magdalena Czarnecka-Operacz
Introduction: The role of long-distance transported (LDT) Ambrosia pollen in inducing new sensitization and affecting sensitization rates in Artemisia -sensitized patients is unclear. Aim: The aim of this study was to estimate the degree of cross-sensitization to Ambrosia/Artemisi a allergens in citizens of Poznan (Western Poland). This area is covered by extensive Artemisia populations but does not currently have local Ambrosia populations. Material and methods: Sera of 119 patients were tested by fluoroenzyme immunoassay (CAP-FEIA system) against pollen allergen extracts of Artemisia vulgaris and Ambrosia artemisiifolia , an allergenic component of A...
February 2018: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29573638/n-linoleoylamino-acids-as-chiral-probes-of-substrate-binding-by-soybean-lipoxygenase-1
#6
Charles H Clapp, Justin Pachuski, Natasha F Bassett, Kathleen A Bishop, Gillian Carter, Megan Young, Thomas Young, Yuhan Fu
Lipoxygenases catalyze the oxygenation of polyunsaturated fatty acids and their derivatives to produce conjugated diene hydroperoxides. Soybean lipoxygenase-1 (SBLO-1) has been the subject of intensive structural and mechanistic study, but the manner in which this enzyme binds substrates is uncertain. Previous studies suggest that the fatty acyl group of the substrate binds in an internal cavity near the catalytic iron with the polar end at the surface of the protein or perhaps external to the protein. To test this model, we have investigated two pairs of enantiomeric N-linoleoylamino acids as substrates for SBLO-1...
March 8, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29568680/action-video-gaming-and-the-brain-fmri-effects-without-behavioral-effects-in-visual-and-verbal-cognitive-tasks
#7
Fabio Richlan, Juliane Schubert, Rebecca Mayer, Florian Hutzler, Martin Kronbichler
Introduction: In this functional magnetic resonance imaging (fMRI) study, we compared task performance together with brain activation in a visuospatial task (VST) and a letter detection task (LDT) between longtime action video gamers ( N  =   14) and nongamers ( N  =   14) in order to investigate possible effects of gaming on cognitive and brain abilities. Methods: Based on previous research, we expected advantages in performance for experienced action video gamers accompanied by less activation (due to higher efficiency) as measured by fMRI in the frontoparietal attention network...
January 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29561503/polarization-variability-in-age-related-macular-degeneration
#8
Dean A VanNasdale, Ann E Elsner, Victor E Malinovsky, Todd D Peabody, Kimberly D Kohne, Bryan P Haggerty, Christopher A Clark
SIGNIFICANCE: Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss. Complementary imaging techniques can be used to better characterize and quantify pathological changes associated with AMD. By assessing specific light-tissue interactions, polarization-sensitive imaging can be used to detect tissue disruption early in the disease process. PURPOSE: The aim of this study was to compare variability in central macular polarization properties in patients with nonexudative AMD and age-matched control subjects...
March 21, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29533862/analytical-validation-of-a-novel-multiplex-test-for-detection-of-advanced-adenoma-and-colorectal-cancer-in-symptomatic-patients
#9
Roslyn Dillon, Lisa J Croner, John Bucci, Stefanie N Kairs, Jia You, Sharon Beasley, Mark Blimline, Rochele B Carino, Vicky C Chan, Danissa Cuevas, Jeff Diggs, Megan Jennings, Jacob Levy, Ginger Mina, Alvin Yee, Bruce Wilcox
Early detection of colorectal cancer (CRC) is key to reducing associated mortality. Despite the importance of early detection, approximately 40% of individuals in the United States between the ages of 50-75 have never been screened for CRC. The low compliance with colonoscopy and fecal-based screening may be addressed with a non-invasive alternative such as a blood-based test. We describe here the analytical validation of a multiplexed blood-based assay that measures the plasma concentrations of 15 proteins to assess advanced adenoma (AA) and CRC risk in symptomatic patients...
February 23, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29489662/motor-development-delay-in-offspring-is-associated-with-prenatal-telbivudine-exposure
#10
Chengliang Zhou, Ying Yu, Qian Yang, Huihui Wang, Min Hou, Li Jin, Fanghong Zhang, Jiangzhong Sheng, Mingfang Miao, Xiaofu Yang, He-Feng Huang
Telbivudine is an orally nucleoside analog with potent and specific antihepatitis B virus (HBV) activity, and it has been reported to block mother-to-infant transmission. However, few studies have focused on the safety of prenatal exposure for offspring development.This is a prospective noninterventional study. Participants were enrolled during delivery through the Women's Hospital of Zhejiang University School of Medicine between January 2012 and September 2013. Neonate's umbilical cord arterial blood (UCAB) was collected after delivery...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29480583/stress-augments-the-rewarding-memory-of-cocaine-via-the-activation-of-brainstem-reward-circuitry
#11
Fumiya Shinohara, Yuta Asaoka, Hironori Kamii, Masabumi Minami, Katsuyuki Kaneda
Effects of stress on the reward system are well established in the literature. Although previous studies have revealed that stress can reinstate extinguished addictive behaviors related to cocaine, the effects of stress on the rewarding memory of cocaine are not fully understood. Here, we provide evidence that stress potentiates the expression of rewarding memory of cocaine via the activation of brainstem-reward circuitry using a cocaine-induced conditioned place preference (CPP) paradigm combined with restraint stress in rats...
February 26, 2018: Addiction Biology
https://www.readbyqxmd.com/read/29476797/the-pedunculopontine-and-laterodorsal-tegmental-nuclei-in-the-kainate-model-of-epilepsy
#12
Joana I Soares, Ana R Afonso, Gisela H Maia, Nikolai V Lukoyanov
Prior studies showed epilepsy can be associated with reorganization of the septohippocampal cholinergic fiber system. Using the kainate model of epilepsy, we wished to further examine the structural integrity of the mesopontine tegmental nuclei (pedunculopontine, PPN, and laterodorsal, LDT), which provide the cholinergic input to the thalamus. It was found that the total numbers of the PPN and LDT cells immunoreactive to the vesicular acetylcholine transporter did not differ between control and epileptic rats...
February 21, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29458251/pushing-nonlinear-optical-oxides-into-the-mid-infrared-spectral-region-beyond-10-%C3%AE-m-design-synthesis-and-characterization-of-la3snga5o14
#13
Haichao Lan, Fei Liang, Xingxing Jiang, Cong Zhang, Haohai Yu, Zheshuai Lin, Huaijin Zhang, Jiyang Wang, Yicheng Wu
Mid-infrared (mid-IR) coherent light is crucial for several applications in science as well as daily life, and its development especially in powerful augmentation is constrained by the availability of nonlinear optical (NLO) materials. The development of useful mid-IR NLO materials is limited by the requirements of a wide mid-IR transparent window, high laser damaged threshold (LDT), and strong NLO effect. It is common knowledge that oxides are not suitable mid-IR NLO materials, as their IR absorption cutoff wavelengths are usually less than 6 μm; however, their LDTs and NLO effects can be large...
February 19, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29452730/external-validation-of-a-decision-tree-early-warning-score-using-only-laboratory-data-a-retrospective-review-of-prospectively-collected-data
#14
Tara E Holm Atkins, Malin C Öhman, Mikkel Brabrand
INTRODUCTION: Early warning scores (EWS) have been developed to identify the degree of illness severity among acutely ill patients. One system, The Laboratory Decision Tree Early Warning Score (LDT-EWS) is wholly laboratory data based. Laboratory data was used in the development of a rare computerized method, developing a decision tree analysis. This article externally validates LDT-EWS, which is obligatory for an EWS before clinical use. METHOD: We conducted a retrospective review of prospectively collected data based on a time limited sample of all patients admitted through the medical admission unit (MAU) on a Danish secondary hospital...
February 13, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29424465/clinical-utility-of-plasma-fructosamine-concentration-as-a-hypoglycemic-biomarker-during-early-lactation-in-dairy-cattle
#15
A A Megahed, M W H Hiew, P D Constable
BACKGROUND: Plasma fructosamine concentration ([FRA]) is a widely used long term hyperglycemic biomarker in humans and dogs, but its clinical usefulness as a hypoglycemic biomarker in dairy cattle is uncertain. OBJECTIVES: To evaluate the relationship between plasma [FRA] and glucose concentration ([gluc]) as well as indices of energy balance during early lactation in dairy cattle, and to characterize the influence of plasma total protein concentration ([TP]) and albumin concentration ([albumin]) on [FRA]...
February 9, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29414161/serial-lantern-shaped-draft-tube-enhanced-flashing-light-effect-for-improving-co2-fixation-with-microalgae-in-a-gas-lift-circumflux-column-photobioreactor
#16
Qing Ye, Jun Cheng, Wangbiao Guo, Junchen Xu, Ke Li, Junhu Zhou
A novel serial lantern-shaped draft tube (LDT) that generates vortices is proposed to increase radial velocity between dark and light regions for improving CO2 fixation with microalgae in a gas-lift circumflux column (GCC) photobioreactor. Clockwise vortices are generated in the downflow outerloop of the GCC photobioreactor with LDT. Radial velocity was improved from 1.50 to 4.35 × 10-2 m/s, thereby decreased liquid cycle period between dark and light regions by 1.9 times. Mixing time decreased by 21%, and mass transfer coefficient increased by 26% with LDT...
January 31, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29411536/use-of-the-22c3-anti-programmed-death-ligand-1-antibody-to-determine-programmed-death-ligand-1-expression-in-cytology-samples-obtained-from-non-small-cell-lung-cancer-patients
#17
Marius Ilie, Jonathan Juco, Lingkang Huang, Veronique Hofman, Shirin Khambata-Ford, Paul Hofman
BACKGROUND: Pembrolizumab monotherapy is a standard-of-care treatment for the first- and second-line treatment of advanced non-small cell lung cancer with programmed death ligand 1 (PD-L1) tumor proportion score (TPS) values ≥ 50% and ≥ 1%, respectively. PD-L1 testing with the PD-L1 immunohistochemistry (IHC) 22C3 pharmDx companion assay has been validated on tumor tissue with the Dako Autostainer Link 48 (ASL48). 22C3 anti-PD-L1 antibody-based laboratory-developed tests (LDTs) compatible with other autostainers and cytology samples are essential to support pembrolizumab treatment decisions across institutions globally...
February 7, 2018: Cancer Cytopathology
https://www.readbyqxmd.com/read/29392744/international-survey-on-high-and-low-dose-synacthen-test-and-assessment-of-accuracy-in-preparing-low-dose-synacthen
#18
Alexandra S Cross, E Helen Kemp, Anne White, Leanne Walker, Suzanne Meredith, Pooja Sachdev, Nils P Krone, Richard J Ross, Neil P Wright, Charlotte J Elder
OBJECTIVE: The short synacthen test (SST) is widely used to assess patients for adrenal insufficiency but the frequency and protocols used across different centres for the low-dose test (LDT) are unknown. This study aimed to survey centres and test the accuracy of ten different synacthen preparation strategies used for the LDT. METHODS: Members of six international endocrine societies were surveyed regarding diagnostic tests used for adrenal insufficiency, and in particular the SST...
February 2, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29361422/arthroscopically-assisted-latissimus-dorsi-transfer-for-irreparable-rotator-cuff-insufficiency-modes-of-failure-and-clinical-correlation
#19
Jean Kany, Jean Grimberg, Rajkumar S Amaravathi, Padmanaban Sekaran, Dan Scorpie, Jean David Werthel
PURPOSE: The main objective of this retrospective study was to analyze the rate and modes of failure of latissimus dorsi transfer (LDT). The secondary objective was to evaluate whether a rupture of the transfer was associated with a worse outcome. METHODS: During a 2-year period, we performed consecutive LDTs either for irreparable posterior-superior rotator cuff tears (RCTs) or for failed prior repair. All the LDTs were performed by a single surgeon. All transfers were arthroscopically assisted and fixed as a tubularized LD tendon in a bone tunnel inside the humeral head...
April 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29351573/multicenter-french-harmonization-study-for-pd-l1-ihc-testing-in-non-small-cell-lung-cancer
#20
J Adam, N Le Stang, I Rouquette, A Cazes, C Badoual, H Pinot-Roussel, L Tixier, C Danel, F Damiola, D Damotte, F Penault-Llorca, S Lantuéjoul
Background: Various PD-L1 immunohistochemistry (IHC) assays have been developed and used in clinical trials in association with different drugs. In order to harmonize and make PD-L1 testing in non-small cell lung cancer (NSCLC) widely available, we conducted a multicenter study comparing PD-L1 standardized assays and laboratory-developed tests (LDT). Methods: IHC with five anti-PD-L1 monoclonal antibodies (28-8, 22C3, E1L3N, SP142 and SP263) was performed concomitantly on 41 NSCLC surgical specimens in 7 centers using Dako Autostainer Link 48 (3 centers), Leica Bond (2 centers) or Ventana BenchMark Ultra (2 centers), platforms...
January 16, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
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