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https://www.readbyqxmd.com/read/28704190/modulating-effects-of-cholecalciferol-treatment-on-estrogen-deficiency-induced-anxiety-like-behavior-of-adult-female-rats
#1
Julia Fedotova, Daria Zarembo, Jozef Dragasek, Martin Caprnda, Peter Kruzliak, Tatyana Dudnichenko
BACKGROUND: Vitamin D can be one of the candidate substances that are used as additional supplementation in the treatment of anxiety-related disorders in women with estrogen imbalance. MATERIALS AND METHODS: The aim of the present study was to examine the effects of chronic cholecalciferol administration (1.0, 2.5 or 5.0 mg/kg/day, s.c.) on the anxiety-like behavior and monoamines levels in the rat hippocampus following ovariectomy in female rats. Cholecalciferol was given to ovariectomized (OVX) rats and OVX rats treated with 17β-estradiol (17β-E2, 0...
June 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28687634/laboratory-developed-tests-a-legislative-and-regulatory-review
#2
REVIEW
Jonathan R Genzen, Jeffrey S Mohlman, Jerry L Lynch, Michael W Squires, Ronald L Weiss
BACKGROUND: Twenty-five years ago, the Food and Drug Administration (FDA) asserted in a draft document that "home brew" tests-now commonly referred to as laboratory-developed tests (LDTs)-are subject to the same regulatory oversight as other in vitro diagnostics (IVDs)(4). In 2010, the FDA began work on developing a proposed framework for future LDT oversight. Released in 2014, the draft guidance sparked an intense debate over potential LDT regulation. While the proposed guidance has not been implemented, many questions regarding LDT oversight remain unresolved...
July 7, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28685879/agga2ps6-a-new-mid-infrared-nonlinear-optical-material-with-high-laser-damage-threshold-and-large-second-harmonic-generation-response
#3
Jiang-He Feng, Chun-Li Hu, Xiang Xu, Bing-Xuan Li, Ming-Jian Zhang, Jiang-Gao Mao
To develop new mid-infrared (MIR) nonlinear optical (NLO) materials, which can overcome the low laser damage threshold (LDT) of the commercial MIR-NLO crystals (AgGaS2, AgGaSe2 and ZnGeP2) and simultaneously keep the large NLO susceptibility, is urgent for the high-power MIR laser frequency conversion technology. To improve the LID, a new strategy of increasing lattice stability was adopted. Here, the strong covalent structural unit of PS4 tetrahedron was introduced into AgGaS2, and that led to the isolation of the first compound in Ag(I)-Ga(III)-P(V)-S system, namely, AgGa2PS6 (Cc)...
July 7, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28670195/cortisol-response-to-low-dose-1-%C3%A2%C2%B5g-acth-stimulation-for-the-prediction-of-outcome-in-patients-with-systemic-inflammatory-response-syndrome
#4
Jelica Bjekić-Macut, Vojislav Radosavljević, Zoran Andrić, Dušan Ilić, Olivera Stanojlović, Danijela Vojnović Milutinović, Ivana Božić Antić, Marija Zdravković, Saša Hinić, Djuro Macut, Miloš Žarković
BACKGROUND: Systemic inflammatory response syndrome (SIRS) changes cortisol dynamics and indicates dissociation between the adrenal cortex and the hypothalamo-pituitary unit. The aim of this study was to assess the cortisol response after stimulation with ACTH1-24 in patients with SIRS at admission to the Respiratory Intensive Care Unit (RICU) and seven days later. METHODS: Fifty-four subjects were included in the study, and SIRS was defined according to the Consensus Conference criteria from 1992...
October 2016: Journal of Medical Biochemistry
https://www.readbyqxmd.com/read/28668402/comparative-study-of-post-transplant-outcomes-in-hepatocellular-carcinoma-patients-treated-with-chemoembolization-or-radioembolization
#5
Ahmed Gabr, Nadine Abouchaleh, Rehan Ali, Michael Vouche, Rohi Atassi, Khairuddin Memon, Ali Al Asadi, Talia Baker, Juan Carlos Caicedo, Kush Desai, Jonathan Fryer, Ryan Hickey, Michael Abeccassis, Ali Habib, Elias Hohlastos, Daniel Ganger, Laura Kulik, Robert J Lewandowski, Ahsun Riaz, Riad Salem
PURPOSE: To analyze long-term outcomes in patients bridged/downstaged to orthotopic liver transplantation (OLT) by transarterial chemoembolization (TACE) or yttrium-90 radioembolization (Y90) for hepatocellular carcinoma (HCC). METHODS: 172 HCC patients who underwent OLT after being treated with transarterial liver-directed therapies (LDTs) (Y90: 93; TACE: 79) were identified. Pre-LDT and pre-OLT clinical/imaging/laboratory characteristics including United Network for Organ Sharing (UNOS) staging and alpha-fetoprotein values (AFP) were tabulated...
August 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28656162/evaluation-of-changes-in-the-tibiotalar-joint-after-high-tibial-osteotomy
#6
Seyed Morteza Kazemi, Mohamad Qoreishi, Ehsan Behboudi, Alireza Manafi, Seyed Kamyar Kazemi
BACKGROUND: There are limited studies regarding the effects of high tibial osteotomy (HTO) on other areas of lower extremity. In current study, we investigated the changes of tibiotalar joint following HTO. METHODS: A total of 39 patients with genu varum requiring HTO were enrolled in this before and after study. The genu varus, joint diversion (JDA), lateral distal tibial (LDTA) and lateral distal tibial-ground surface (LDT-GSA) angles were measured before the operation and compared with 6 months after the surgery...
May 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/28655610/neuropeptide-s-nps-is-a-neuropeptide-with-cellular-actions-in-arousal-and-anxiety-related-nuclei-functional-implications-for-effects-of-nps-on-wakefulness-and-mood
#7
Vincenzo Roncacè, Filip Souza Polli, Minella Zojicic, Kristi Anne Kohlmeier
Neuropeptide S (NPS) is a peptide recently recognized to be present in the CNS, and believed to play a role in vigilance and mood control, as behavioral studies have shown it promotes arousal and has an anxiolytic effect. Although NPS precursor is found in very few neurons, NPS positive fibers are present throughout the brain stem. Given the behavioral actions of this peptide and the wide innervation pattern, we examined the cellular effects of NPS within two brain stem nuclei known to play a critical role in anxiety and arousal: the dorsal raphe (DR) and laterodorsal tegmentum (LDT)...
June 24, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28639033/functional-restoration-of-cd56-bright-nk-cells-facilitates-immune-control-via-il-15-and-nkg2d-in-patients-under-antiviral-treatment-for-chronic-hepatitis-b
#8
Tao Chen, Lin Zhu, Aichao Shi, Lin Ding, Xiaoping Zhang, Zhenmin Tan, Wei Guo, Weiming Yan, Meifang Han, Jidong Jia, Xiaoping Luo, Detlef Schuppan, Qin Ning
BACKGROUND AND AIMS: Hepatitis B virus (HBV) is intrinsically immunogenic, with long-lasting immune control in many patients. However, the mechanisms and key cell types underlying effective immune control are incompletely understood. METHODS: We studied the restoration of natural killer (NK) cell numbers and function post antiviral treatment in 52 hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) patients who received telbivudine (LdT) for 48 weeks...
June 20, 2017: Hepatology International
https://www.readbyqxmd.com/read/28614010/diagnostic-accuracy-of-basal-cortisol-level-to-predict-adrenal-insufficiency-in-cosyntropin-testing-results-from-an-observational-cohort-study-with-804-patients
#9
Tristan Struja, Leonie Briner, Aline Meier, Alexander Kutz, Esther Mundwiler, Andreas Huber, Beat Mueller, Luca Bernasconi, Philipp Schuetz
CONTEXT: ACTH stimulation testing is the current standard for the assessment of primary and secondary adrenal insufficiency (AI). We aimed to investigate the value of basal cortisol level for prediction of AI. METHODS: We retrospectively analyzed 804 consecutive patients who had high-dose (250μg, HDT) or low-dose (1μg, LDT) ACTH testing as part of their diagnostic work-up. Site-specific cut-off levels for AI were <550 in HDT and <500nmol/L in LDT, respectively...
June 14, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28596834/acute-cocaine-exposure-elicits-rises-in-calcium-in-arousal-related-laterodorsal-tegmental-neurons
#10
Mads Ødum Lambert, Theis Højland Ipsen, Kristi Anne Kohlmeier
Cocaine has strong reinforcing properties, which underlie its high addiction potential. Reinforcement of use of addictive drugs is associated with rises in dopamine (DA) in mesoaccumbal circuitry. Excitatory afferent input to mesoaccumbal circuitry sources from the laterodorsal tegmental nucleus (LDT). Chronic, systemic cocaine exposure has been shown to have cellular effects on LDT cells, but acute actions of local application have never been demonstrated. Using calcium imaging, we show that acute application of cocaine to mouse brain slices induces calcium spiking in cells of the LDT...
February 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28591041/relationship-of-treg-th17-balance-with-hbeag-change-in-hbeag-positive-chronic-hepatitis-b-patients-receiving-telbivudine-antiviral-treatment-a-longitudinal-observational-study
#11
Xiaoling Yang, Jia Li, Jie Liu, Min Gao, Li Zhou, Wei Lu
Telbivudine (LdT) is an orally L-nucleoside with potent and specific antihepatitis B virus (HBV) activity. The higher rate of hepatitis B e antigen (HBeAg) seroconversion of LdT treatment than other anti-HBV agents suggests a potential immunomodulatory effect. The aim of the study was to investigate the changes of regulatory T cell (Treg)/interleukin (IL)-17-producing CD4+T helper (Th17) balance during LdT treatment and to discuss the relationship of Treg/Th17 balance with HBeAg change in HBeAg-positive chronic hepatitis B (CHB) patients receiving LdT antiviral treatment...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28562554/effectiveness-of-entecavir-or-telbivudine-therapy-in-patients-with-chronic-hepatitis-b-virus-infection-pre-treated-with-interferon-compared-with-de-novo-therapy-with-entecavir-and-telbivudine
#12
COMPARATIVE STUDY
Shaohang Cai, Jiawei Cao, Tao Yu, Muye Xia, Jie Peng
Little is known about the optimal treatment following the initial failure of interferon therapy and the potential different efficacy with de novo therapy with entecavir (ETV) or telbivudine (LDT) and following the interferon therapy failure.ETV or LDT therapy following the interferon therapy failure was compared with that of de novo therapy with ETV or LDT in patients with chronic hepatitis B virus (HBV) infection. Treatment parameters included virological response, hepatitis B e antigen (HBeAg) seroconversion, and alanine aminotransferase (ALT) normalization...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28514980/evaluation-of-benzimidazole-resistance-status-in-ascaridia-galli
#13
B Tarbiat, D S Jansson, E Tydén, J Höglund
Susceptability of Ascaridia galli to benzimidazole (BZ) was investigated using faecal egg count reduction test (FECRT), in ovo larval development test (LDT) and genetic markers (mutations at codons 167, 198 and 200 of β-tubulin gene). Six flocks (F1-F6) of a commercial laying hen farm with different number of exposure to BZ were recruited. The FECR was calculated by analyzing individual faeces (F1, F2, F4 and F5) before and 10 days after treatment. The LDT was performed on parasite eggs from pooled samples from F1 to F6 and LC50 and LC99 were calculated...
May 18, 2017: Parasitology
https://www.readbyqxmd.com/read/28507292/growth-properties-and-theoretical-analysis-of-m2livo4-m%C3%A2-%C3%A2-rb-cs-crystals-two-potential-mid-infrared-nonlinear-optical-materials
#14
Guopeng Han, Ying Wang, Xin Su, Zhihua Yang, Shilie Pan
Mid-Infrared nonlinear optical (Mid-IR NLO) crystals with excellent performances play a particularly important role for applications in areas such as telecommunications, laser guidance, and explosives detection. However, the design and growth of high performance Mid-IR NLO crystals with large NLO efficiency and high laser-damage threshold (LDT) still face numerous fundamental challenge. In this study, two potential Mid-IR NLO materials, Rb2LiVO4 (RLVO) and Cs2LiVO4 (CLVO) with noncentrosymmetric structures (Orthorhombic, Cmc21) were synthesized by high-temperature solution method...
May 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28502726/utility-of-nist-whole-genome-reference-materials-for-the-technical-validation-of-a-multigene-next-generation-sequencing-test
#15
Bennett O V Shum, Ilya Henner, Daniele Belluoccio, Marcus J Hinchcliffe
The sensitivity and specificity of next-generation sequencing laboratory developed tests (LDTs) are typically determined by an analyte-specific approach. Analyte-specific validations use disease-specific controls to assess an LDT's ability to detect known pathogenic variants. Alternatively, a methods-based approach can be used for LDT technical validations. Methods-focused validations do not use disease-specific controls but use benchmark reference DNA that contains known variants (benign, variants of unknown significance, and pathogenic) to assess variant calling accuracy of an NGS workflow...
May 11, 2017: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/28459655/comparative-analyses-of-zebrafish-anxiety-like-behavior-using-conflict-based-novelty-tests
#16
Elana V Kysil, Darya A Meshalkina, Erin E Frick, David J Echevarria, Denis B Rosemberg, Caio Maximino, Monica Gomes Lima, Murilo S Abreu, Ana C Giacomini, Leonardo J G Barcellos, Cai Song, Allan V Kalueff
Modeling of stress and anxiety in adult zebrafish (Danio rerio) is increasingly utilized in neuroscience research and central nervous system (CNS) drug discovery. Representing the most commonly used zebrafish anxiety models, the novel tank test (NTT) focuses on zebrafish diving in response to potentially threatening stimuli, whereas the light-dark test (LDT) is based on fish scototaxis (innate preference for dark vs. bright areas). Here, we systematically evaluate the utility of these two tests, combining meta-analyses of published literature with comparative in vivo behavioral and whole-body endocrine (cortisol) testing...
June 2017: Zebrafish
https://www.readbyqxmd.com/read/28438529/an-erp-investigation-of-vertical-reading-fluency-in-scrabble-%C3%A2-experts
#17
Sophia van Hees, Sabine Seyffarth, Penny M Pexman, Filomeno Cortese, Andrea B Protzner
Previous studies have found that competitive Scrabble expertise is associated with enhanced performance on visual lexical decision tasks (LDT), particularly for vertically presented stimuli. In the current study, we investigated the underlying mechanisms responsible for this vertical fluency. We examined behaviour and neural activity during LDT in 19 competitive Scrabble players and 18 matched controls. Using event related potentials (ERP), we investigated whether Scrabble expertise modulates the N170, P300, and late positive component (LPC), associated with visual-orthographic processing, working memory, and stimulus classification, respectively...
April 21, 2017: Brain Research
https://www.readbyqxmd.com/read/28438504/agomelatine-protects-against-neuronal-damage-without-preventing-epileptogenesis-in-the-kainate-model-of-temporal-lobe-epilepsy
#18
Jana Tchekalarova, Dimitrinka Atanasova, Zlatina Nenchovska, Milena Atanasova, Lidia Kortenska, Rumyana Gesheva, Nikolai Lazarov
Recent studies about the novel antidepressant agomelatine, which is a mixed MT1 and MT2 melatonin receptor agonist and 5HT2C serotonin receptor antagonist possessing an anticonvulsant and neuroprotective action, suggest that it may have potential to contribute against epileptogenesis and epilepsy-induced memory impairment. In order to ascertain whether protection of some brain structures could suppress epileptogenesis, in the present study, we evaluated the effect of chronic post-status treatment with agomelatine on epileptogenesis, behavioral and neuronal damage induced by kainate acid (KA) status epilepticus (SE)...
April 21, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28433759/reverse-shoulder-arthroplasty-combined-with-latissimus-dorsi-transfer-a-systemic-review
#19
REVIEW
R Ortmaier, W Hitzl, N Matis, G Mattiassich, J Hochreiter, H Resch
Reverse shoulder arthroplasty (RSA) combined with latissimus dorsi transfer (LDT) is described for patients with cuff arthropathy and a combined loss of abduction and external rotation. The purpose of this systemic review was to present clinical and radiological outcomes following RSA combined with LDT. A comprehensive literature review was performed to identify studies reporting clinical and radiological results of RSA combined with LDT. Seven articles that describe the treatment of 116 patients were selected...
April 20, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28406121/normalization-of-the-psychometric-hepatic-encephalopathy-score-for-diagnosis-of-minimal-hepatic-encephalopathy-in-turkey
#20
Bdo Coskun, M Ozen, S Gursoy, O Ozbakir, O K Poyrazoglu, M Baskol, G C Sezgin, M Yucesoy
AIM: To construct normal values for the tests of the psychometric hepatic encephalopathy score (PHES) and evaluate the prevalence of minimal hepatic encephalopathy (MHE) among Turkish patients with liver cirrhosis. MATERIALS AND METHODS: One hundred and eighty-five healthy subjects and sixty patients with liver cirrhosis without overt hepatic encephalopathy were included in the study. All subjects underwent psychometric tests, which include number connection test-A and B (NCT-A/B), serial dotting test (DST), line drawing test (LDT), and digit symbol test (DST) in the same day...
April 2017: Nigerian Journal of Clinical Practice
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