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https://www.readbyqxmd.com/read/29913379/the-role-of-social-support-in-family-socio-economic-disparities-in-depressive-symptoms-during-early-pregnancy-evidence-from-a-chinese-birth-cohort
#1
Dong-Mei Wei, Shiu Lun Au Yeung, Jian-Rong He, Wan-Qing Xiao, Jin-Hua Lu, Si Tu, Nian-Nian Chen, Kin Bong Hubert Lam, Kar-Keung Cheng, Gabriel M Leung, Hui-Min Xia, C Mary Schooling, Xiu Qiu
BACKGROUND: Few studies have examined the association between a composite measure of family socio-economic position (SEP)2 and depressive symptoms among Chinese pregnant women, nor any potential underlying mechanisms which may be amenable to preventative interventions. METHODS: We investigated the association between a composite SEP measure and depressive symptoms during early pregnancy, and tested for mediation by social support and moderation by parity in the Born in Guangzhou Cohort Study (n = 12,382) using adjusted logistic regression and causal mediation analysis...
June 5, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29912967/patients-perceptions-of-their-experiences-with-nurse-patient-communication-in-oncology-settings-a-focused-ethnographic-study
#2
Engle Angela Chan, Fiona Wong, Man Yin Cheung, Winsome Lam
BACKGROUND: The nursing shortage and its impact on patient care are well-documented global issues. Patients living with cancer as a chronic illness have many psychosocial problems and often lack adequate support as a result of ineffective nurse-patient communication. A review of the literature on factors influencing the delivery of psychosocial care to cancer patients indicates that the delivery of psychosocial care in routine cancer nursing within a biomedical healthcare system has not been widely explored...
2018: PloS One
https://www.readbyqxmd.com/read/29910071/detection-of-traumatic-pancreatic-duct-disruption-in-the-modern-era
#3
Morgan Schellenberg, Kenji Inaba, James M Bardes, Vincent Cheng, Kazuhide Matsushima, Lydia Lam, Elizabeth Benjamin, Demetrios Demetriades
BACKGROUND: Pancreatic trauma management hinges upon the presence or absence of pancreatic duct injury, but the optimal method of assessment is unclear. This study endeavored to evaluate the methods of pancreatic duct assessment in modern practice. METHODS: Patients presenting to LAC + USC Medical Center (01/2008-06/2015) with a pancreatic injury were identified (ICD-9 codes). Demographics, clinical data, technique of duct evaluation, and outcomes were analyzed...
June 12, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29909754/angioimmunoblastic-t-cell-lymphoma-a-prognostic-model-from-a-retrospective-study
#4
Huangming Hong, Xiaojie Fang, Zhao Wang, He Huang, Sio Teng Lam, Fangfang Li, Chen Peng, Ying Tian, Suxia Lin, Tongyu Lin
Angioimmunoblastic T-cell lymphoma (AITL) is a distinct subtype of peripheral T-cell lymphoma with unique clinical and pathological features. This study aim to design a prognostic model specifically for AITL, providing risk stratification in affected patients. A total of 115 newly diagnosed AITL patients were retrospectively analyzed. The estimated five-year overall survival (OS) rate for all patients was 45.4%. Multivariate analysis found prognostic factors for survival were bone marrow involvement, number of extranodal sites >1, and performance status >1...
June 18, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29909734/anatomic-feasibility-of-percutaneous-cholecystoenteric-fistula-creation-and-stent-insertion-in-acute-cholecystitis
#5
Rebecca Zener, Lee L Swanström, Eran Shlomovitz
OBJECTIVE: To assess the prevalence of patients whose anatomy would be potentially amenable to percutaneous cholecystoenteric lumen-apposing metallic stents (LAMS) insertion from a population of acute cholecystitis patients. METHODS: Contrast-enhanced abdominal computed tomography images in 100 consecutive adult patients with acute cholecystitis were reviewed retrospectively. Feasibility of LAMS placement percutaneously or with endoscopic ultrasound guidance was defined as the presence of a straight and unobstructed trajectory from the skin to the gallbladder, and between the gallbladder and the gastric antrum, or the proximal duodenum, measuring ≤2 cm, respectively...
June 1, 2018: Surgical Innovation
https://www.readbyqxmd.com/read/29909708/recombinant-human-thrombopoietin-rh-tpo-for-the-prevention-of-severe-thrombocytopenia-induced-by-high-dose-cytarabine-a-prospective-randomized-self-controlled-study
#6
Zhao Wang, Xiaojie Fang, He Huang, Huangming Hong, Xueying Li, Chengcheng Guo, Xiaohong Fu, Mengping Zhang, Sio Teng Lam, Shanshan Li, Fangfang Li, Chen Peng, Ying Tian, Tongyu Lin
The aim of this randomized phase II study was to investigate the optimal timing of the administration of thrombopoietin to prevent cytarabine-induced thrombocytopenia. Fifty-two patients who were scheduled for high-dose cytarabine treatment were randomly assigned to receive either the standard prophylactic mode (starting thrombopoietin, 15,000 units/day on days 2-11) or the pre-chemo mode (starting thrombopoietin, 15,000 units/day on days -4, -2, and 2-9) during the first cycle of chemotherapy with a switch to the other mode in the second cycle...
June 18, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29909357/abdominal-muscle-recruitment-and-its-effect-on-the-activity-level-of-the-hip-and-posterior-thigh-muscles-during-therapeutic-exercises-of-the-hip-joint
#7
Sharon M H Tsang, Amanda H M Lam, Melody H L Ng, Kiki W K Ng, Cherry O H Tsui, Benjamin Yiu
Abdominal exercise has been advocated to improve the protection of the spine and neuromuscular efficiency of the limb movements. The purpose of this study was to examine the effect of enhanced contraction of internal oblique and transversus abdominis (IO/TrA) on the activity level of the hip and posterior thigh muscles during therapeutic hip exercises. Twenty healthy females were required to perform eight hip exercises under two conditions, natural versus enhanced IO/TrA contraction conditions. Muscle activity of gluteus maximus, gluteus medius, tensor fasciae latae and biceps femoris of the exercising leg was measured by surface electromyography during hip exercises, and expressed in percentage normalized to the maximal voluntary isometric contraction (%MVIC)...
June 12, 2018: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29909305/the-association-of-duration-and-severity-of-disease-with-executive-function-differences-between-drug-na%C3%A3-ve-patients-with-bipolar-and-unipolar-depression
#8
Tao Yang, Guoqing Zhao, Ruizhi Mao, Jia Huang, Xianrong Xu, Yousong Su, Na Zhu, Rubai Zhou, Xiao Lin, Weiping Xia, Fan Wang, Rui Liu, Xing Wang, Zhijia Huang, Yong Wang, Yingyan Hu, Lan Cao, Chengmei Yuan, Zuowei Wang, Raymond W Lam, Jun Chen, Yiru Fang
BACKGROUND: The aims of this study were to investigate the differences in executive function and the relationship with clinical factors between drug-naïve patients with bipolar depression (BDD) and unipolar depression (UPD). METHODS: Drug-naïve patients with BDD, UPD and healthy controls (HC) were recruited (30 cases in each group). All patients were assessed with Hamilton Rating Scale for Anxiety (HAM-A), Hamilton Rating Scale for Depression-17 (HAM-D), and Young Mania Rating Scale (YMRS)...
May 29, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29907897/correction-to-preservation-of-motor-maps-with-increased-motor-evoked-potential-amplitude-threshold-in-rmt-determination
#9
Giuseppe Lucente, Steven Lam, Heike Schneider, Thomas Picht
Funding information is added.
June 16, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29907552/beyond-maximum-grade-modernising-the-assessment-and-reporting-of-adverse-events-in-haematological-malignancies
#10
REVIEW
Gita Thanarajasingam, Lori M Minasian, Frederic Baron, Franco Cavalli, R Angelo De Claro, Amylou C Dueck, Tarec C El-Galaly, Neil Everest, Jan Geissler, Christian Gisselbrecht, John Gribben, Mary Horowitz, S Percy Ivy, Caron A Jacobson, Armand Keating, Paul G Kluetz, Aviva Krauss, Yok Lam Kwong, Richard F Little, Francois-Xavier Mahon, Matthew J Matasar, María-Victoria Mateos, Kristen McCullough, Robert S Miller, Mohamad Mohty, Philippe Moreau, Lindsay M Morton, Sumimasa Nagai, Simon Rule, Jeff Sloan, Pieter Sonneveld, Carrie A Thompson, Kyriaki Tzogani, Flora E van Leeuwen, Galina Velikova, Diego Villa, John R Wingard, Sophie Wintrich, John F Seymour, Thomas M Habermann
Tremendous progress in treatment and outcomes has been achieved across the whole range of haematological malignancies in the past two decades. Although cure rates for aggressive malignancies have increased, nowhere has progress been more impactful than in the management of typically incurable forms of haematological cancer. Population-based data have shown that 5-year survival for patients with chronic myelogenous and chronic lymphocytic leukaemia, indolent B-cell lymphomas, and multiple myeloma has improved markedly...
June 12, 2018: Lancet Haematology
https://www.readbyqxmd.com/read/29907335/trial-protocol-the-use-of-mindfulness-based-intervention-for-improving-bracing-compliance-for-adolescent-idiopathic-scoliosis-patients-protocol-for-a-randomised-controlled-trial
#11
Benjamin Hon Kei Yip, Xue Li, Christine Hiu Yan Leung, Ting Gao, Vincent Chi Ho Chung, Fiona Wai Ping Yu, Tsz Ping Lam, Jack Chun Yiu Cheng, Samuel Yeung Shan Wong
INTRODUCTION: Adolescent idiopathic scoliosis (AIS) is the most prevalent deforming orthopaedic condition; it causes significant disability when spinal curves progress beyond 45deg. Bracing is the primary treatment prescribed for adolescents with an immature skeleton who have spinal curves between 25 and 45deg. New evidence suggests that compliance with bracing significantly decreases the progression of high-risk curves to the threshold for surgery. Nonetheless, bracing is a stressful experience...
June 12, 2018: Journal of Physiotherapy
https://www.readbyqxmd.com/read/29906249/aberrant-mir-145-5p-%C3%AE-catenin-signal-impairs-osteocyte-function-in-adolescent-idiopathic-scoliosis
#12
Jiajun Zhang, Huanxiong Chen, Ross K K Leung, Kwong Wai Choy, Tsz-Ping Lam, Bobby K W Ng, Yong Qiu, Jian Q Feng, Jack C Y Cheng, Wayne Y W Lee
Recently, noncoding RNAs have been thought to play important roles in the sporadic occurrence of spinal deformity of adolescent idiopathic scoliosis (AIS). As a prognostic factor for curve progression, low bone mass has been hypothesized to crosstalk with AIS pathogenesis. Abnormal osteoblasts activities are reported in AIS without a clear mechanism. In this study, bone biopsies from patients with AIS and control subjects and the primary osteoblasts derived from those samples were used to identify the potential microRNA (miRNA) candidates that interfere with osteoblasts and osteocytes function...
June 15, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29905796/heart-failure-with-preserved-ejection-fraction-from-mechanisms-to-therapies
#13
Carolyn S P Lam, Adriaan A Voors, Rudolf A de Boer, Scott D Solomon, Dirk J van Veldhuisen
This review aims to provide a translational perspective on recent developments in heart failure with preserved ejection fraction (HFpEF), linking mechanistic insights to potential therapies. A key concept in this review is that HFpEF is a haemodynamic condition wherein the heart fails to keep up with the circulatory demands of the body, or does so at the expense of raised left ventricular filling pressures. We, therefore, propose that the 'final common pathway' for development of congestion, i.e. basic haemodynamic mechanisms of increased left ventricular end-diastolic pressure, left atrial hypertension, pulmonary venous congestion, and plasma volume expansion, represents important initial targets for therapy in HFpEF...
June 13, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29904387/anti-lipoarabinomannan-specific-salivary-iga-as-prognostic-marker-for-leprosy-reactions-in-patients-and-cellular-immunity-in-contacts
#14
André Alan Nahas, Mayara Ingrid de Sousa Lima, Isabela Maria Bernardes Goulart, Luiz Ricardo Goulart
Leprosy causes the most common peripheral neuropathy of infectious etiology, posing an important public health problem worldwide. Understanding the molecular and immunological mechanisms of nerve damage induced by M. leprae is mandatory to develop tools for early diagnosis and preventive measures. The phenolic glycolipid 1 (PGL-1) and lipoarabinomannan (LAM) antigens are major components of the bacterial surface and are implicated on leprosy immunopathogenesis and neural damage. Although the anti-PGL-1 serum IgM is highly used for operational classification of patients, the anti-LAM salivary IgA (sIgA) has not been investigated as diagnostic or prognostic marker in leprosy...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29904383/influenza-a-virus-facilitates-its-infectivity-by-activating-p53-to-inhibit-the-expression-of-interferon-induced-transmembrane-proteins
#15
Bei Wang, Tze Hau Lam, Mun Kuen Soh, Zhiyong Ye, Jinmiao Chen, Ee Chee Ren
Human influenza virus (IAV) are among the most common pathogens to cause human respiratory infections. A better understanding on interplay between IAV and host factors may provide clues for disease prevention and control. While many viruses are known to downregulate p53 upon entering the cell to reduce the innate host antiviral response, IAV infection is unusual in that it activates p53. However, it has not been clear whether this process has proviral or antiviral effects. In this study, using human isogenic p53 wild-type and p53null A549 cells generated from the CRISPR/Cas9 technology, we observed that p53null cells exhibit significantly reduced viral propagation when infected with influenza A virus (strain A/Puerto Rico/8/1934 H1N1)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29903977/shear-elegance-a-novel-screen-uncovers-a-mechanosensitive-gpcr
#16
Ruby M Lam, Alexander T Chesler
No abstract text is available yet for this article.
June 14, 2018: Journal of General Physiology
https://www.readbyqxmd.com/read/29903871/liver-and-colon-specific-dna-methylation-markers-in-plasma-for-investigation-of-colorectal-cancers-with-or-without-liver-metastases
#17
Wanxia Gai, Lu Ji, W K Jacky Lam, Kun Sun, Peiyong Jiang, Anthony W H Chan, John Wong, Paul B S Lai, Simon S M Ng, Brigette B Y Ma, Grace L H Wong, Vincent W S Wong, Henry L Y Chan, Rossa W K Chiu, Y M Dennis Lo, K C Allen Chan
BACKGROUND: Measurement of DNA derived from different tissues in the circulating DNA pool can provide important information regarding the presence of many pathological conditions. However, existing methods involving genome-wide bisulfite sequencing are relatively expensive and may present challenges for large-scale analysis. METHODS: Through identifying differentially methylated regions in the liver and colon compared with other tissues, we identified 2 markers and developed corresponding droplet digital PCR assays...
June 14, 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29903421/patient-and-hospital-level-predictors-of-vancomycin-resistant-enterococcus-vre-bacteremia-in-ontario-canada
#18
Jennie Johnstone, Cynthia Chen, Laura Rosella, Kwaku Adomako, Michelle E Policarpio, Freda Lam, Chatura Prematunge, Gary Garber
BACKGROUND: Data are limited on risk factors for vancomycin-resistant Enterococcus (VRE) bacteremia. METHODS: All patients with a confirmed VRE bacteremia in Ontario, Canada, between January 2009 and December 2013 were linked to provincial healthcare administrative data sources and frequency matched to 3 controls based on age, sex, and aggregated diagnosis group. Associations between predictors and VRE bacteremia were estimated by generalized estimating equations and summarized using odds ratios (ORs) and corresponding 95% confidence intervals (CIs)...
June 11, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29902988/additional-hepatic-166-ho-radioembolization-in-patients-with-neuroendocrine-tumours-treated-with-177-lu-dotatate-a-single-center-interventional-non-randomized-non-comparative-open-label-phase-ii-study-hepar-plus-trial
#19
Arthur J A T Braat, Dik J Kwekkeboom, Boen L R Kam, Jaap J M Teunissen, Wouter W de Herder, Koen M A Dreijerink, Rob van Rooij, Gerard C Krijger, Hugo W A M de Jong, Maurice A A J van den Bosch, Marnix G E H Lam
BACKGROUND: Neuroendocrine tumours (NET) consist of a heterogeneous group of neoplasms with various organs of origin. At diagnosis 21% of the patients with a Grade 1 NET and 30% with a Grade 2 NET have distant metastases. Treatment with peptide receptor radionuclide therapy (PRRT) shows a high objective response rate and long median survival after treatment. However, complete remission is almost never achieved. The liver is the most commonly affected organ in metastatic disease and is the most incriminating factor for patient survival...
June 15, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29902048/measuring-variations-in-bicultural-identity-across-u-s-ethnic-and-generational-groups-development-and-validation-of-the-bicultural-identity-integration-scale-version-2-biis-2
#20
Que-Lam Huynh, Verònica Benet-Martínez, Angela-MinhTu D Nguyen
Bicultural Identity Integration (BII) is an individual difference construct that captures variations in the experience of biculturalism. Using multiple samples in a series of steps, we refined BII measurement and then tested the construct in a diverse sample of bicultural individuals. Specifically, we wrote new BII items based on qualitative data ( n = 108), examined the quality of the new measure using subject-matter experts ( n = 23) and bicultural individuals ( n = 5), and then collected validation data from bicultural college students ( n = 1049)...
June 14, 2018: Psychological Assessment
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