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https://www.readbyqxmd.com/read/28823113/dual-mode-endomicroscopy-for-detection-of-epithelial-dysplasia-in-the-mouth-a-descriptive-pilot-study
#1
Nico Bodenschatz, Catherine F Poh, Sylvia Lam, Pierre Lane, Martial Guillaud, Calum E MacAulay
Dual-mode endomicroscopy is a diagnostic tool for early cancer detection. It combines the high-resolution nuclear tissue contrast of fluorescence endomicroscopy with quantified depth-dependent epithelial backscattering as obtained by diffuse optical microscopy. In an in vivo pilot imaging study of 27 oral lesions from 21 patients, we demonstrate the complementary diagnostic value of both modalities and show correlations between grade of epithelial dysplasia and relative depth-dependent shifts in light backscattering...
August 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28823029/experience-of-lung-transplantation-in-patients-with-lymphangioleiomyomatosis-at-a-brazilian-reference-centre
#2
Bruno Guedes Baldi, Marcos Naoyuki Samano, Silvia Vidal Campos, Martina Rodrigues de Oliveira, José Eduardo Afonso Junior, Rafael Medeiros Carraro, Ricardo Henrique Oliveira Braga Teixeira, Isabela Pasqualini Minguini, Roni Burlina, Eduardo Zinoni Silva Pato, Carlos Roberto Ribeiro Carvalho, André Nathan Costa
INTRODUCTION: Lung transplantation (LT) is the standard of care for patients with advanced lung diseases, including lymphangioleiomyomatosis (LAM). LAM accounts for only 1% of all LTs performed in the international registry. As a result, the global experience, including the use of mechanistic target of rapamycin (mTOR) inhibitors before and after LT in LAM, is still limited. METHODS: We conducted a retrospective review of all LAM patients who underwent LT at our centre between 2003 and 2016...
August 19, 2017: Lung
https://www.readbyqxmd.com/read/28822622/novel-in-vivo-and-in-vitro-techniques-to-image-and-model-the-cerebral-vasculature-in-sickle-cell-disease
#3
Erin M Buckley, Manu O Platt, Wilbur A Lam
No abstract text is available yet for this article.
August 12, 2017: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/28822552/consequences-of-dietary-energy-source-and-energy-level-on-energy-balance-lactogenic-hormones-and-lactation-curve-characteristics-of-cows-after-a-short-or-omitted-dry-period
#4
R J van Hoeij, J Dijkstra, R M Bruckmaier, J J Gross, T J G M Lam, G J Remmelink, B Kemp, A T M van Knegsel
Omitting the dry period (DP) generally reduces milk production in the subsequent lactation. The aim of this study was to evaluate the effect of dietary energy source-glucogenic (G) or lipogenic (L)-and energy level-standard (std) or low-on milk production; energy balance (EB); lactogenic hormones insulin, insulin-like growth factor 1 (IGF-1), and growth hormone (GH); and lactation curve characteristics between wk 1 and 44 postpartum in cows after a 0-d or 30-d DP. Cows (n = 110) were assigned randomly to 3 transition treatments: a 30-d DP with a standard energy level required for expected milk yield [30-d DP(std)], a 0-d DP with the same energy level as cows with a 30-d DP [0-d DP(std)], and a 0-d DP with a low energy level [0-d DP(low)]...
August 16, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28821862/water-soluble-epitaxial-nacl-thin-film-for-fabrication-of-flexible-devices
#5
Dong Kyu Lee, Sungjoo Kim, Sein Oh, Jae-Young Choi, Jong-Lam Lee, Hak Ki Yu
We studied growth mechanisms of water-soluble NaCl thin films on single crystal substrates. Epitaxial growth of NaCl(100) on Si(100) and domain-matched growth of NaCl(111) on c-sapphire were obtained at thicknesses below 100 nm even at room temperature from low lattice mismatches in both cases. NaCl thin film, which demonstrates high solubility selectivity for water, was successfully applied as a water-soluble sacrificial layer for fabrication of several functional materials, such as WO3 nano-helix and Sn doped In2O3 nano-branches...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28820275/in-vitro-anti-acne-activity-of-phytoactives-from-the-stem-bark-of-artocarpus-hirsutus-lam-and-characterisation-of-pyranocycloartobiloxanthone-a-as-a-mixture-of-two-anomers
#6
Mahadeva Nayak, A Nagarajan, Muhammed Majeed, Kalyanam Nagabhushanam, Ambar K Choudhury
This study is aimed to isolate the phytoactives from the stem bark of Artocarpus hirsutus and evaluate their in vitro anti-acne activity. The ethanolic stem bark extract of A. hirsutus provided two major phytoactive constituents: (i) pyranocycloartobiloxanthone A, (1) and (ii) Artonine E, (2) whose structures were determined by NMR and MS spectroscopic analysis. The present study is the first to report compound 1 as a mixture of two anomers (α and β), approximately 70:30 ratio. Both compounds 1 and 2 were isolated for the first time from this plant...
August 18, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28819908/the-effect-of-cationically-modified-phosphorylcholine-polymers-on-human-osteoblasts-in-vitro-and-their-effect-on-bone-formation-in-vivo
#7
Jonathan M Lawton, Mariam Habib, Bingkui Ma, Roger A Brooks, Serena M Best, Andrew L Lewis, Neil Rushton, William Bonfield
The effect of introducing cationic charge into phosphorylcholine (PC)-based polymers has been investigated in this study with a view to using these materials as coatings to improve bone formation and osseointegration at the bone-implant interface. PC-based polymers, which have been used in a variety of medical devices to improve biocompatibility, are associated with low protein adsorption resulting in reduced complement activation, inflammatory response and cell adhesion. However, in some applications, such as orthopaedics, good integration between the implant and bone is needed to allow the distribution of loading stresses and a bioactive response is required...
August 17, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28819798/functional-organometallic-poly-arylene-ethynylene-s-from-synthesis-to-applications
#8
REVIEW
Jie Zhang, Linli Xu, Cheuk-Lam Ho, Wai-Yeung Wong
This review focuses on the recent development in the rigid-rod metallopolymers of late transition metals based on triple-bond building blocks. The synthesis, structure-property relationships and potential applications of organometallic poly(arylene ethynylene)s will be discussed in detail. These functional metal-based polymers can exhibit intriguing optical, electronic and magnetic properties. Considerable focus is placed on the design strategies towards tuning the optical bandgap and emission color (spanning almost the whole visible spectrum) of this class of metallopolymers, and the investigation of their use as active materials for light/electrical energy conversion and energy and information storage...
August 17, 2017: Topics in Current Chemistry (Journal)
https://www.readbyqxmd.com/read/28819604/posterior-knee-loose-bodies-treated-by-posterior-knee-arthroscopy
#9
Ho Lam Chai, Tun Hing Lui
INTRODUCTION: The posterior portion of the knee joint, which includes the tibial attachment of the posterior cruciate ligament and the posterior horn of the menisci, has been called a "blind spot" because it is difficult to observe this area under arthroscopy through standard anterior portals. Posteromedial, posterolateral, and posterior transseptal portals have been developed for visualization and instrumentation of the posteromedial and posterolateral compartments of the knee joint...
March 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28819521/boerhaave-s-syndrome-food-particles-in-chest-tube
#10
Lam Nguyen Ho, Hang Le Van
No abstract text is available yet for this article.
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28818845/a-scoping-review-for-strategies-to-increase-living-kidney-donation
#11
Lianne Barnieh, David Collister, Braden Manns, Ngan N Lam, Soroush Shojai, Diane Lorenzetti, John S Gill, Scott Klarenbach
BACKGROUND AND OBJECTIVES: The literature on strategies to increase the number of potential living kidney donors is extensive and has yet to be characterized. Scoping reviews are a novel methodology for systematically assessing a wide breadth of a given body of literature and may be done before conducting a more targeted systematic review. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We performed a scoping review and summarized the evidence for existing strategies to increase living kidney donation...
August 17, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28818393/the-modulation-of-the-phosphorylation-status-of-nkcc1-in-organ-cultured-bovine-lenses-implications-for-the-regulation-of-fiber-cell-and-overall-lens-volume
#12
Irene Vorontsova, Paul J Donaldson, Zhiying Kong, Chiharu Wickremesinghe, Leo Lam, Julie C Lim
In this study we have used an antibody that specifically detects the phosphorylation status of the Sodium/Potassium/2 Chloride Cotransporter (NKCC1) to study whether the activity of NKCC1 can be regulated in organ cultured bovine lenses. Western blotting was first used to confirm the expression of NKCC1, phosphorylated NKCC1 (NKCC1-P) and the regulatory kinases WNK/SPAK and phosphatases PP1/PP2A in bovine lenses at the protein level. Changes to NKCC1-P status were then assessed by organ culturing bovine lenses in either isotonic, hypertonic or hypotonic solutions in the presence or absence of the NKCC inhibitor, bumetanide, or phosphatase inhibitors okadaic acid and calyculin A...
August 14, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28818208/catecholamine-dependent-%C3%AE-adrenergic-signaling-in-a-pluripotent-stem-cell-model%C3%A2-of-takotsubo-cardiomyopathy
#13
Thomas Borchert, Daniela Hübscher, Celina I Guessoum, Tuan-Dinh D Lam, Jelena R Ghadri, Isabel N Schellinger, Malte Tiburcy, Norman Y Liaw, Yun Li, Jan Haas, Samuel Sossalla, Mia A Huber, Lukas Cyganek, Claudius Jacobshagen, Ralf Dressel, Uwe Raaz, Viacheslav O Nikolaev, Kaomei Guan, Holger Thiele, Benjamin Meder, Bernd Wollnik, Wolfram-Hubertus Zimmermann, Thomas F Lüscher, Gerd Hasenfuss, Christian Templin, Katrin Streckfuss-Bömeke
BACKGROUND: Takotsubo syndrome (TTS) is characterized by an acute left ventricular dysfunction and is associated with life-threating complications in the acute phase. The underlying disease mechanism in TTS is still unknown. A genetic basis has been suggested to be involved in the pathogenesis. OBJECTIVES: The aims of the study were to establish an in vitro induced pluripotent stem cell (iPSC) model of TTS, to test the hypothesis of altered β-adrenergic signaling in TTS iPSC-cardiomyocytes (CMs), and to explore whether genetic susceptibility underlies the pathophysiology of TTS...
August 22, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28817263/responses-of-periphyton-to-fe2o3-nanoparticles-a-physiological-and-ecological-basis-for-defending-nanotoxicity
#14
Jun Tang, Ningyuan Zhu, Yan Zhu, Junzhuo Liu, Chenxi Wu, Philip G Kerr, Yonghong Wu, Kwan Sing Paul Kwan-Sing Lam
The toxic effects of nanoparticles on individual organisms have been widely investigated, while few studies have investigated the effects of nanoparticles on ubiquitous multi-community microbial aggregates. Here, periphyton as a model of microbial aggregates, was employed to investigate the responses of microbial aggregates exposed continuously to Fe2O3 nanoparticles (5.0 mg L-1) for 30 days. The Fe2O3 nanoparticles enter the microbial cells of the periphyton and disperse in the cytoplasm. The exposure to Fe2O3 nanoparticles results in the chlorophyll (a, b and c) contents of periphyton increasing and the total antioxidant capacity decreasing...
August 17, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28817248/attenuated-suppression-of-lipolysis-explains-increases-in-triglyceride-secretion-and-concentration-with-basal-insulin-peglispro-bil-relative-to-insulin-glargine-treatment-in-patients-with-type-1-diabetes
#15
Rakel Fuglsang Johansen, Esben Søndergaard, Helle Linnebjerg, Parag Garhyan, Eric Chen Quin Lam, Niels Porksen, Scott J Jacober, Søren Nielsen
AIMS: In patients with type 1 diabetes, basal insulin peglispro (BIL) lowers weight and increases plasma triglycerides (TG) and hepatic fat relative to insulin glargine (GL). To explain this, we hypothesised that BIL's attenuated peripheral effects may include increased free fatty acid flux to the liver, causing increased VLDL-TG secretion and lipid oxidation, and decreased TG adipose tissue deposition. MATERIALS AND METHODS: In this open-label, randomised, 2-period crossover study, 14 patients with type 1 diabetes received once-daily, individualised, stable BIL or GL doses for 3 weeks...
August 17, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28815716/characterization-of-h5n6-highly-pathogenic-avian-influenza-viruses-isolated-from-wild-and-captive-birds-in-the-winter-season-of-2016-2017-in-northern-japan
#16
Takahiro Hiono, Masatoshi Okamatsu, Keita Matsuno, Atsushi Haga, Ritsuko Iwata, Lam Thanh Nguyen, Mizuho Suzuki, Yuto Kikutani, Hiroshi Kida, Manabu Onuma, Yoshihiro Sakoda
On November 15, 2016, a suspected case of highly pathogenic avian influenza (HPAI) in a dead black swan was reported from a zoo in Akita prefecture, northern Japan, and an HPAI virus (HPAIV) belonging to the H5N6 subtype was isolated from specimens taken from the bird. After the initial report, 230 cases of HPAI caused by H5N6 viruses were reported from wild birds, captive birds, and domestic poultry farms throughout the country during the winter season. In the present study, we further characterized 66 H5N6 HPAIVs isolated from northern Japan...
August 16, 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/28815666/dorsomedial-prefrontal-cortex-repetitive-transcranial-magnetic-stimulation-treatment-of-posttraumatic-stress-disorder-in-eating-disorders-an-open-label-case-series
#17
D Blake Woodside, Patricia Colton, Eileen Lam, Katharine Dunlop, Julia Rzeszutek, Jonathan Downar
Posttraumatic stress disorder (PTSD) is a common comorbid condition in anorexia nervosa (AN) and bulimia nervosa (BN), and may be associated with reduced response to treatment. We report on a case series employing repetitive transcranial magnetic stimulation (rTMS) with a novel target, the dorsomedial prefrontal cortex (DMPFC). Fourteen subjects with eating disorders and comorbid PTSD received 20-30 neuronavigated DMPFC-rTMS treatments on an open-label basis. PTSD symptoms were assessed pretreatment and posttreatment with the PTSD checklist-Civilian (PCL-C) and the Difficulties in Emotional Regulation Scale (DERS)...
August 16, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28815415/type-2-diabetes-with-comorbid-depression-in-relation-to-cognitive-impairment-an-opportunity-for-prevention
#18
David A Zhang, Vicky Lam, Vanessa Chu, Ming Li
Studies show poor glycemic control is associated with increased risk of dementia among patients with Type 2 diabetes, indicating potential for prevention of dementia with improved glycemia. Emerging evidence suggests that a relationship between short-term glycemic control and cognitive function exists in Type 2 diabetes. However, detailed mechanisms relating diabetic dementia are lacking, as other concurrent conditions, such as depression, may also increase the risk of dementia in Type 2 diabetes. We examined the effects of glycemic control and depression on cognitive function in 88 patients (mean age, 67 ± 4 years) whose A1c (glycosylated hemoglobin) levels, comorbid depression, mini-mental state examination (MMSE) scores were recorded at baseline...
August 16, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28813575/subclinical-decrease-in-central-inner-retinal-activity-is-associated-with-myopia-development-in-children
#19
Serena Zhe-Chuang Li, Wing-Yan Yu, Kai-Yip Choi, Christie Hang-I Lam, Yamunadevi Lakshmanan, Francisca Siu-Yin Wong, Henry Ho-Lung Chan
Purpose: To investigate the characteristics of retinal electrophysiological activity in relation to early myopia development in children. Methods: Fifty-six children aged 6 to 9 years with emmetropic refractive error (defined as ≥ -0.5 diopter [D] and ≤ +0.5 D) were recruited. Cycloplegic refraction, axial length, and global flash multifocal electroretinogram (MOFO mfERG) at 49% and 96% contrast levels were recorded in all children at their first visit. The refraction and axial length measurements were repeated after 1 year...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28813417/cmtm6-maintains-the-expression-of-pd-l1-and-regulates-anti-tumour-immunity
#20
Marian L Burr, Christina E Sparbier, Yih-Chih Chan, James C Williamson, Katherine Woods, Paul A Beavis, Enid Y N Lam, Melissa A Henderson, Charles C Bell, Sabine Stolzenburg, Omer Gilan, Stuart Bloor, Tahereh Noori, David W Morgens, Michael C Bassik, Paul J Neeson, Andreas Behren, Phillip K Darcy, Sarah-Jane Dawson, Ilia Voskoboinik, Joseph A Trapani, Jonathan Cebon, Paul J Lehner, Mark A Dawson
Cancer cells exploit the expression of the programmed death-1 (PD-1) ligand 1 (PD-L1) to subvert T-cell-mediated immunosurveillance. The success of therapies that disrupt PD-L1-mediated tumour tolerance has highlighted the need to understand the molecular regulation of PD-L1 expression. Here we identify the uncharacterized protein CMTM6 as a critical regulator of PD-L1 in a broad range of cancer cells, by using a genome-wide CRISPR-Cas9 screen. CMTM6 is a ubiquitously expressed protein that binds PD-L1 and maintains its cell surface expression...
August 16, 2017: Nature
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