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https://www.readbyqxmd.com/read/29679239/comparative-analysis-of-the-root-transcriptomes-of-cultivated-and-wild-rice-varieties-in-response-to-magnaporthe-oryzae-infection-revealed-both-common-and-species-specific-pathogen-responses
#1
Lei Tian, Shaohua Shi, Fahad Nasir, Chunling Chang, Weiqiang Li, Lam-Son Phan Tran, Chunjie Tian
BACKGROUND: Magnaporthe oryzae, the causal fungus of rice blast disease, negatively impacts global rice production. Wild rice (Oryza rufipogon), a relative of cultivated rice (O. sativa), possesses unique attributes that enable it to resist pathogen invasion. Although wild rice represents a major resource for disease resistance, relative to current cultivated rice varieties, no prior studies have compared the immune and transcriptional responses in the roots of wild and cultivated rice to M...
April 20, 2018: Rice
https://www.readbyqxmd.com/read/29678708/a-comparative-analysis-of-the-utility-of-glioblastoma-patient-survival-prediction-models-in-the-temozolomide-era-the-importance-of-mgmt-promoter-methylation-extent-of-resection-and-subventricular-zone-location
#2
Peter Woo, Jason Ho, Sandy Lam, Eric Ma, Danny Chan, Wai-Kei Wong, Calvin Mak, Michael Lee, Sui-To Wong, Kwong-Yau Chan, Wai-Sang Poon
No abstract text is available yet for this article.
April 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29678511/correlation-of-the-new-york-heart-association-classification-and-the-cardiopulmonary-exercise-test-a-systematic-review
#3
Fang Yi Lim, Jonathan Yap, Fei Gao, Ling Li Teo, Carolyn S P Lam, Khung Keong Yeo
AIMS: The New York Heart Association (NYHA) classification is frequently used in the management of heart failure but may be limited by patient and physician subjectivity. Cardiopulmonary exercise testing (CPET) provides a potentially more objective measurement of functional status. We aim to study the correlation between NYHA classification and peak oxygen consumption (pVO2 ) on Cardiopulmonary Exercise Testing (CPET) within and across published studies. METHODS AND RESULTS: A systematic literature review on all studies reporting both NYHA class and CPET data was performed, and pVO2 from CPET was correlated to reported NYHA class within and across eligible studies...
April 7, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29676458/an-optimized-method-to-measure-human-foxp3-regulatory-t-cells-from-multiple-tissue-types-using-mass-cytometry
#4
Nicholas A J Dawson, Avery J Lam, Laura Cook, Romy E Hoeppli, Raewyn Broady, Anne M Pesenacker, Megan K Leving
Mass cytometry has facilitated the discovery of complex immunological networks and immune cell interactions; however, there are limited reports of using this technology to measure expression of intranuclear antigens such as transcription factors. Herein we describe testing of multiple staining methods to detect FOXP3, the lineage-defining transcription factor for regulatory T cells (Tregs), by mass cytometry. A custom paraformaldehyde/saponin-based fixation and permeabilization method was found to be the optimal method for mass cytometry-based Treg detection, yielding the best balance of FOXP3 detection and preserved cell surface marker expression...
April 20, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29675687/clinical-characteristics-in-lymphangioleiomyomatosis-related-pulmonary-hypertension-an-observation-on-50-patients
#5
Xiuxiu Wu, Wenshuai Xu, Jun Wang, Xinlun Tian, Zhuang Tian, Kaifeng Xu
Lymphangioleiomyomatosis (LAM) is a rare diffuse cystic lung disease. Knowledge on LAM-related pulmonary hypertension (PH) is limited. This study aimed to analyze the clinical characteristics of LAM with elevated pulmonary artery pressure (PAP) and evaluate the potential efficacy of sirolimus. The study involved 50 LAM patients who underwent echocardiography. According to the tricuspid regurgitation velocity (TRV), these patients were divided into the TRV ≤ 2.8 m/s group and TRV > 2.8 m/s group. Both groups comprised 25 females with an average age of 38...
April 19, 2018: Frontiers of Medicine
https://www.readbyqxmd.com/read/29675226/a-densely-modified-m-2-independent-dnazyme-that-cleaves-rna-efficiently-with-multiple-catalytic-turnover
#6
Yajun Wang, Erkai Liu, Curtis H Lam, David M Perrin
Sequence-specific cleavage of RNA targets in the absence of a divalent metal cation (M2+ ) has been a long-standing goal in bioorganic chemistry. Herein, we report the in vitro selection of novel RNA cleaving DNAzymes that are selected using 8-histaminyl-deoxyadenosine (dAim TP), 5-guanidinoallyl-deoxyuridine (dUga TP), and 5-aminoallyl-deoxycytidine (dCaa TP) along with dGTP. These modified dNTPs provide key functionalities reminiscent of the active sites of ribonucleases, notably RNase A. Of several such M2+ -free DNAymes, DNAzyme 7-38-32 cleaves a 19 nt all-RNA substrate with multiple-turnover, under simulated physiological conditions wherein only 0...
February 21, 2018: Chemical Science
https://www.readbyqxmd.com/read/29674496/gfi1-is-required-for-runx1-eto-positive-acute-myeloid-leukemia
#7
Anna E Marneth, Lacramioara Botezatu, Judith M Hönes, Jimmy C L Israël, Judith Schütte, Lothar Vassen, Robert F Lams, Saskia M Bergevoet, Laura Groothuis, Amit Mandoli, Joost H A Martens, Gerwin Huls, Joop H Jansen, Ulrich Dührsen, Tobias Berg, Tarik Möröy, Christian Wichmann, Mia-Chia Lo, Dong-Er Zhang, Bert A van der Reijden, Cyrus Khandanpour
No abstract text is available yet for this article.
April 19, 2018: Haematologica
https://www.readbyqxmd.com/read/29674416/altered-white-matter-microstructure-in-the-corpus-callosum-and-its-cerebral-interhemispheric-tracts-in-adolescent-idiopathic-scoliosis-diffusion-tensor-imaging-analysis
#8
C Xue, L Shi, S C N Hui, D Wang, T P Lam, C-B Ip, B K W Ng, J C Y Cheng, W C W Chu
BACKGROUND AND PURPOSE: Neural system was one of the important contributors to the etiopathogenesis of adolescent idiopathic scoliosis; additionally, the morphology of corpus callosum interconnecting both hemispheres of the brain was found to be altered morphologically. Our aim was to evaluate and compare the microstructural changes of the corpus callosum and its interhemispheric white matter fiber tracts interconnecting both cerebral hemispheres in patients with adolescent idiopathic scoliosis and matched controls using diffusion tensor imaging...
April 19, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29672637/optimisation-of-quantitative-mirna-panels-to-consolidate-the-diagnostic-surveillance-of-hbv-related-hepatocellular-carcinoma
#9
Ngo Tat Trung, Dang Chieu Duong, Hoang Van Tong, Tran Thi Thu Hien, Phan Quoc Hoan, Mai Hong Bang, Mai Thanh Binh, Thai Doan Ky, Nguyen Lam Tung, Nguyen Tien Thinh, Vu Viet Sang, Le Thi Phuong Thao, C-Thomas Bock, Thirumalaisamy P Velavan, Christian G Meyer, Le Huu Song, Nguyen Linh Toan
BACKGROUND: Circulating microRNAs (miRNA) are biomarkers for several neoplastic diseases, including hepatocellular carcinoma (HCC). We performed a literature search, followed by experimental screening and validation in order to establish a miRNA panel in combination with the assessment of alpha-fetoprotein (AFP) levels and to evaluate its performance in HCC diagnostics. METHODS: Expression of miRNAs was quantified by quantitative PCR (qPCR) in 406 serum samples from 118 Vietnamese patients with hepatitis B (HBV)-related HCC, 69 patients with HBV-related liver cirrhosis (LC), 100 chronic hepatitis B (CHB) patients and 119 healthy controls (HC)...
2018: PloS One
https://www.readbyqxmd.com/read/29672463/limited-additional-value-of-cervical-ultrasonography-over-a-negative-18f-fdg-pet-ct-for-diagnosing-cervical-lymph-node-metastases-in-patients-with-esophageal-cancer-a-systematic-review-and-meta-analysis
#10
Lucas Goense, Jihane Meziani, Peter S N van Rossum, Frank J Wessels, Gert J Meijer, Marnix G E H Lam, Richard van Hillegersberg, Jelle P Ruurda
OBJECTIVE: To assess the additional value of cervical ultrasonography as supplement to a negative fluorine-18-fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) for detecting cervical lymph node metastases during the initial staging of patients with esophageal cancer. METHODS: PubMed/Medline, Embase, and the Cochrane library were systematically searched. The analysis included diagnostic studies describing the accuracy of cervical ultrasonography and integrated F-FDG PET/CT or standalone F-FDG PET and CT for detecting cervical lymph node metastases in patients with esophageal cancer...
April 18, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29672294/endoscopic-ultrasound-guided-choledocho-enterostomy-by-using-lumen-apposing-metal-stent-in-patients-with-failed-endoscopic-retrograde-cholangiopancreatography-a-literature-review
#11
Deepanshu Jain, Manan Shah, Upen Patel, Abhinav Sharma, Shashideep Singhal
BACKGROUND: Endoscopic retrograde cholangiopancreatography (ERCP) has been the cornerstone in the management of malignant jaundice to provide symptomatic relief and/or to allow chemotherapy. Difficult biliary cannulation or the presence of concomitant duodenal obstruction may lead to its failure. METHOD: An extensive English literature search was done via PubMed and Google Scholar to identify 13 peer-reviewed original articles. RESULTS: Of 92 patients, 98...
April 19, 2018: Digestion
https://www.readbyqxmd.com/read/29672264/an-evidence-and-risk-based-approach-to-a-harmonized-laboratory-alert-list-in-australia-and-new-zealand
#12
Craig A Campbell, Que Lam, Andrea R Horvath
Individual laboratories are required to compose an alert list for identifying critical and significant risk results. The high-risk result working party of the Royal College of Pathologists of Australasia (RCPA) and the Australasian Association of Clinical Biochemists (AACB) has developed a risk-based approach for a harmonized alert list for laboratories throughout Australia and New Zealand. The six-step process for alert threshold identification and assessment involves reviewing the literature, rating the available evidence, performing a risk analysis, assessing method transferability, considering workload implications and seeking endorsement from stakeholders...
April 19, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29671551/duration-of-bisphosphonate-therapy
#13
Helen C Lam, Christie M Thomas, Julia M Shaver
No abstract text is available yet for this article.
April 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/29669930/tsc2-deficient-tumors-have-evidence-of-t-cell-exhaustion-and-respond-to-anti-pd-1-anti-ctla-4-immunotherapy
#14
Heng-Jia Liu, Patrick H Lizotte, Heng Du, Maria C Speranza, Hilaire C Lam, Spencer Vaughan, Nicola Alesi, Kwok-Kin Wong, Gordon J Freeman, Arlene H Sharpe, Elizabeth P Henske
Tuberous sclerosis complex (TSC) is an incurable multisystem disease characterized by mTORC1-hyperactive tumors. TSC1/2 mutations also occur in other neoplastic disorders, including lymphangioleiomyomatosis (LAM) and bladder cancer. Whether TSC-associated tumors will respond to immunotherapy is unknown. We report here that the programmed death 1 coinhibitory receptor (PD-1) is upregulated on T cells in renal angiomyolipomas (AML) and pulmonary lymphangioleiomyomatosis (LAM). In C57BL/6J mice injected with syngeneic TSC2-deficient cells, anti-PD-1 alone decreased 105K tumor growth by 67% (P < 0...
April 19, 2018: JCI Insight
https://www.readbyqxmd.com/read/29669550/cardiorespiratory-health-effects-of-gaseous-ambient-air-pollution-exposure-in-low-and-middle-income-countries-a-systematic-review-and-meta-analysis
#15
Katherine Newell, Christiana Kartsonaki, Kin Bong Hubert Lam, Om Kurmi
BACKGROUND: Lack of research on the effects of gaseous pollutants (nitrogen oxides [NOx ], sulfur dioxide [SO2 ], carbon monoxide [CO] and ozone [O3 ]) in the ambient environment on health outcomes from within low and middle income countries (LMICs) is leading to reliance on results from studies performed within high income countries (HICs). This systematic review and meta-analysis examines the cardiorespiratory health effects of gaseous pollutants in LMICs exclusively. METHODS: Systematic searching was carried out and estimates pooled by pollutant, lag and outcome, and presented as excess relative risk per 10 μg/m3 (NOx , SO2 , O3 ) or 1 ppm (CO) increase pollutant...
April 18, 2018: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29669044/polymorphisms-of-arsenic-3-oxidation-state-methyltransferase-and-arsenic-methylation-capacity-affect-the-risk-of-bladder-cancer
#16
Ying-Chin Lin, Wei-Jen Chen, Chao-Yuan Huang, Horng-Sheng Shiue, Chien-Tien Su, Pui-Lam Ao, Yeong-Shiau Pu, Hsueh Yu-Mei
The mechanisms underlying how arsenic methylation capacity affects bladder cancer (BC) are still unclear. The objective of this study was to explore the effects of polymorphisms of arsenic (+3 oxidation state) methyltransferase (AS3MT) on BC risk. We conducted a hospital-based study and enrolled 216 BC and 813 healthy controls from 2007 to 2011. Urinary arsenic profiles were measured using high-performance liquid chromatography-hydride generation-atomic absorption spectrometry. The gene polymorphisms of AS3MT were identified using the Sequenom MassARRAY platform with iPLEX Gold chemistry...
April 14, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29668796/morphophysiology-phenotypic-and-molecular-diversity-of-auxin-induced-passiflora-mucronata-lam-passifloraceae
#17
Juliany M França, Lucimara R Venial, Eloá B Costa, Edilson R Schmildt, Omar Schmildt, Paula M Bernardes, Sandro D Tatagiba, José C Lopes, Marcia F S Ferreira, Rodrigo S Alexandre
Genetic diversity allows identification of potential intraspecific genotypes in the genus Passiflora. The objective of this study was to examine the morphological and genetic diversity of auxin-induced Passiflora mucronata. The experiments were arranged in a complete randomized block design, with a 9 x 2 factorial arrangement (nine genotypes x presence and absence of auxin, indole-3-butyric acid (IBA)), with four replicates of 16 cuttings. The rooting and vegetative growth responses were variable. Genotype 5 was more responsive in the absence of IBA and genotypes 3, 8 and 9 were more responsive in the presence of IBA...
April 16, 2018: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29668391/the-reflective-mind-examining-individual-differences-in-susceptibility-to-base-rate-neglect-with-fmri
#18
Oshin Vartanian, Erin L Beatty, Ingrid Smith, Kristen Blackler, Quan Lam, Sarah Forbes, Wim De Neys
Performance on heuristics and biases tasks has been shown to be susceptible to bias. In turn, susceptibility to bias varies as a function of individual differences in cognitive abilities (e.g., intelligence) and thinking styles (e.g., propensity for reflection). Using a classic task (i.e., lawyer-engineer problem), we conducted two experiments to examine the differential contributions of cognitive abilities versus thinking styles to performance. The results of Experiment 1 demonstrated that the Cognitive Reflection Test (CRT)-a well-established measure of reflective thinking-predicted performance on conflict problems (where base rates and intuition point in opposite directions), whereas STM predicted performance on nonconflict problems...
April 18, 2018: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/29668328/use-of-placebo-in-clinical-trials-of-psychotropic-medication
#19
Mehrul Hasnain, Abraham Rudnick, Weldon S Bonnell, Gary Remington, Raymond W Lam
This position paper has been substantially revised by the Canadian Psychiatric Association's Research Committee and approved for republication by the CPA's Board of Directors on March 31, 2017. The original position paper1 was developed by the Scientific and Research Council and approved by the Board of Directors on October 4, 1996.
May 2018: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/29667709/the-outlet-patch-gastric-heterotopia-of-the-colo-rectum-and-anus
#20
Abul Ala Syed Rifat Mannan, Michael Vieth, Armen Khararjian, Binny Khandakar, Dora Lam-Himlin, David Heydt, Feriyl Bhaijee, Henry J Venbrux, Kathleen Byrnes, Lysandra Voltaggio, Norman Barker, Songyang Yuan, Elizabeth Montgomery
AIMS: Gastric heterotopia (GH) has been described throughout the gastrointestinal tract. However, the colorectal region is an extremely rare location for it. We describe the clinicopathologic features of GH of the colon, rectum, and anus. METHODS AND RESULTS: We identified 33 cases in 20 males and 13 females (median age 54 years; range, 4 months to 73 years). Sites included the rectum (N=26), anus (N=4), ileocecal junction (N=1), ascending colon (N=1) and descending colon (N=1)...
April 18, 2018: Histopathology
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