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JOURNAL ARTICLE
Trevor B Birmingham, Codie A Primeau, Salimah Z Shariff, Jennifer N S Reid, Jacquelyn D Marsh, Melody Lam, Stephanie N Dixon, J Robert Giffin, Kevin R Willits, Robert B Litchfield, Brian G Feagan, Peter J Fowler
IMPORTANCE: It is unclear whether arthroscopic resection of degenerative knee tissues among patients with osteoarthritis (OA) of the knee delays or hastens total knee arthroplasty (TKA); opposite findings have been reported. OBJECTIVE: To compare the long-term incidence of TKA in patients with OA of the knee after nonoperative management with or without additional arthroscopic surgery. DESIGN, SETTING, AND PARTICIPANTS: In this ad hoc secondary analysis of a single-center, assessor-blinded randomized clinical trial performed from January 1, 1999, to August 31, 2007, 178 patients were followed up through March 31, 2019...
April 1, 2024: JAMA Network Open
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JOURNAL ARTICLE
Berkeley K Fahrenthold, Matthew R Cavanaugh, Madhura Tamhankar, Byron L Lam, Steven E Feldon, Brent A Johnson, Krystel R Huxlin
PURPOSE: Damage to the adult primary visual cortex (V1) causes vision loss in the contralateral hemifield, initiating a process of transsynaptic retrograde degeneration (TRD). Here, we examined retinal correlates of TRD using a new metric to account for global changes in inner retinal thickness and asked if perceptual training in the intact or blind field impacts its progression. METHODS: We performed a meta-analysis of optical coherence tomography data in 48 participants with unilateral V1 stroke and homonymous visual defects who completed clinical trial NCT03350919...
April 1, 2024: Investigative Ophthalmology & Visual Science
#3
JOURNAL ARTICLE
Francesco Massari, Matteo Santoni, Hideki Takeshita, Yohei Okada, Jose Carlos Tapia, Umberto Basso, Marco Maruzzo, Sarah Scagliarini, Thomas Büttner, Giuseppe Fornarini, Zin W Myint, Luca Galli, Vinicius Carrera Souza, Renate Pichler, Ugo De Giorgi, Nathalia Gandur, Elaine T Lam, Danielle Gilbert, Lazar Popovic, Enrique Grande, Giulia Mammone, Rossana Berardi, Simon J Crabb, Robert Kemp, Javier Molina-Cerrillo, Marcelo Freitas, Murilo Luz, Roberto Iacovelli, Fabio Calabrò, Deniz Tural, Francesco Atzori, Zsófia Küronya, Rita Chiari, Saul Campos, Orazio Caffo, André P Fay, Jakub Kucharz, Paolo Andrea Zucali, José Augusto Rinck, Annalisa Zeppellini, Diogo Assed Bastos, Gaetano Aurilio, Augusto Mota, Karine Trindade, Cinzia Ortega, Juan Pablo Sade, Mimma Rizzo, Ondřej Fiala, Nuno Vau, Patrizia Giannatempo, Allan Barillas, Fernando Sabino M Monteiro, Breno Dauster, Alessia Mennitto, Lucas Nogueira, Roni de Carvalho Fernandes, Emmanuel Seront, Luís Garcia Aceituno, Francesco Grillone, Hernan Javier Cutuli, Mauricio Fernandez, Maria Bassanelli, Ray Manneh Kopp, Giandomenico Roviello, Halima Abahssain, Giuseppe Procopio, Michele Milella, Jindrich Kopecky, Angelo Martignetti, Carlo Messina, Manuel Caitano, Eva Inman, Ravindran Kanesvaran, Daniel Herchhorn, Daniele Santini, Aristotelis Bamias, Renato Bisonni, Alessandra Mosca, Franco Morelli, Fernando Maluf, Andrey Soares, Fernando Nunes, Alvaro Pinto, Anca Zgura, Lorena Incorvaia, Jawaher Ansari, Ignacio Ortego Zabalza, Johannes Landmesser, Alessandro Rizzo, Veronica Mollica, Andrea Marchetti, Matteo Rosellini, Giulia Sorgentoni, Nicola Battelli, Sebastiano Buti, Camillo Porta, Joaquim Bellmunt
BACKGROUND: Immune checkpoint inhibitors have changed previous treatment paradigm of advanced urothelial carcinoma (UC). The ARON-2 study (NCT05290038) aimed to assess the real-world effectiveness of pembrolizumab in patients recurred or progressed after platinum-based chemotherapy. PATIENTS AND METHODS: Medical records of patients with documented metastatic UC treated by pembrolizumab as second-line therapy were retrospectively collected from 88 institutions in 23 countries...
April 18, 2024: Cancer Immunology, Immunotherapy: CII
#4
JOURNAL ARTICLE
Xin Li, Haoyue Han, Ying Ma, Xin Wang, Xin Lü
As a nutritious plant with valuable potential, the Moringa oleifera Lam. (MOL) leaf addition on Fuzhuan brick tea (FBT) for the co-fermentation (MOL-FBT) was an industry innovation and a new route to make full use of MOL leaf. After optimization of the extraction conditions, the best conditions for the polyphenols extraction method from MOL-FBT (MFP) were 60°C for 40 min (1:80, V/W) using response surface methodology. A total of 30 phenolics were identified and quantified. Most of the polyphenols were increased after adding MOL leaf for co-fermentation compared to FBT polyphenols...
April 17, 2024: Journal of Food Science
#5
JOURNAL ARTICLE
Evan C Ray, Andrew Nickerson, Shaohu Sheng, Rolando Carrisoza-Gaytán, Tracey Lam, Allison Marciszyn, Lei Zhang, Alexa Jordahl, Chunming Bi, Aaliyah Winfrey, Zhaohui Kou, Sebastien Gingras, Annet Kirabo, Lisa M Satlin, Thomas R Kleyman
The ENaC γ subunit is essential for homeostasis of Na+ , K+ , and body fluid. Dual γ subunit cleavage before and after a short inhibitory tract allows dissociation of this tract, increasing channel open probability (PO ), in vitro . Cleavage proximal to the tract occurs at a furin recognition sequence (143 RKRR146 , in the mouse γ subunit). Loss of furin-mediated cleavage prevents in vitro activation of the channel by proteolysis at distal sites. We hypothesized that 143 RKRR146 mutation to 143 QQQQ146 (γQ4 ) in 129/Sv mice would reduce ENaC PO , impair flow-stimulated flux of Na+ (JNa ) and K+ (JK ) in perfused collecting ducts, reduce colonic amiloride-sensitive short circuit current (ISC ), and impair Na+ , K+ , and body fluid homeostasis...
April 18, 2024: American Journal of Physiology. Renal Physiology
#6
Raed Masalma, Thabet Zidan, Khalil M Abualhumos, Dalia Hamayel, Ziad Abukhalil, Ahmed T Ghanem, Adnan Mousa, Maroun Helou, Wesam Tamimi, Mahdi Al-Sayed Ahmad
Thalassemia is known to induce extramedullary hematopoiesis (EMH), which is a compensatory mechanism in which the body forms blood cells outside the bone marrow. While EMH typically affects organs such as the spleen and liver, there are rare instances where it leads to spinal cord compression (SCC) in the epidural space. A 31-year-old male patient with transfusion-dependent beta thalassemia presented with numbness and bilateral limb weakness due to EMH. Neurological examination revealed increased tone in both legs, reduced power, loss of crude touch and pain sensation, and increased deep tendon reflexes...
March 2024: Curēus
#7
REVIEW
Dawood Sayed, Timothy Ray Deer, Jonathan M Hagedorn, Asim Sayed, Ryan S D'Souza, Christopher M Lam, Nasir Khatri, Zohra Hussaini, Scott G Pritzlaff, Newaj Mohammad Abdullah, Vinicius Tieppo Francio, Steven Michael Falowski, Yussr M Ibrahim, Mark N Malinowski, Ryan R Budwany, Natalie Holmes Strand, Kamil M Sochacki, Anuj Shah, Tyler M Dunn, Morad Nasseri, David W Lee, Leonardo Kapural, Marshall David Bedder, Erika A Petersen, Kasra Amirdelfan, Michael E Schatman, Jay Samuel Grider
INTRODUCTION: Painful diabetic neuropathy (PDN) is a leading cause of pain and disability globally with a lack of consensus on the appropriate treatment of those suffering from this condition. Recent advancements in both pharmacotherapy and interventional approaches have broadened the treatment options for PDN. There exists a need for a comprehensive guideline for the safe and effective treatment of patients suffering from PDN. OBJECTIVE: The SWEET Guideline was developed to provide clinicians with the most comprehensive guideline for the safe and appropriate treatment of patients suffering from PDN...
2024: Journal of Pain Research
#8
JOURNAL ARTICLE
Jeff J P M Schulpen, Cindy H X Lam, Rebecca A Dawley, Ruixue Li, Lun Jin, Tao Ma, Wilhelmus M M Kessels, Steven J Koester, Ageeth A Bol
We utilize plasma-enhanced atomic layer deposition to synthesize two-dimensional Nb-doped WS2 and Nb x W1- x S y alloys to expand the range of properties and improve the performance of 2D transition metal dichalcogenides for electronics and catalysis. Using a supercycle deposition process, films are prepared with compositions spanning the range from WS2 to NbS3 . While the W-rich films form crystalline disulfides, the Nb-rich films form amorphous trisulfides. Through tuning the composition of the films, the electrical resistivity is reduced by 4 orders of magnitude compared to pure ALD-grown WS2 ...
April 12, 2024: ACS Applied Nano Materials
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JOURNAL ARTICLE
Riqiang Lin, Shengmiao Lv, Wenjing Lou, Xiatian Wang, Zhihua Xie, Silue Zeng, Rui Chen, Wen Gao, Tianan Jiang, Ka-Wai Eric Cheng, Kwok-Ho Lam, Xiaojing Gong
Optical-resolution photoacoustic endoscopy (OR-PAE) has been proven to realize imaging on the vascular network in the gastrointestinal (GI) tract with high sensitivity and spatial resolution, providing morphological information. Various photoacoustic endoscopic catheters were developed to improve the resolution and adaptivity of in-vivo imaging. However, this technology has not yet been validated on in-vivo GI tumors, which generally feature angiogenesis. The tumor causes thickened mucosa and neoplasia, requiring large depth-of-field (DOF) in imaging, which contradicts to high-resolution imaging...
April 1, 2024: Biomedical Optics Express
#10
JOURNAL ARTICLE
Haojie Chen, Qingshuang Zhou, Xiaojiang Pu, Nannan Wang, Sinian Wang, Zhenhua Feng, Bin Wang, Zezhang Zhu, Yong Qiu, Xu Sun
BACKGROUND CONTEXT: Vertebral endplate defects are often implicated in degenerative disc disorders, yet their connection to patient-reported symptoms remains unclear. COX-2 and PGE-2 are known for their roles in inflammation and pain, with EP-4 receptor involvement in pain signaling. Examining their expression in vertebral endplate tissues may provide insights into pathomechanism of low back pain. PURPOSE: To investigate the association between endplate defects and patient-reported symptoms and to further clarify the role of the COX-2/PGE-2/EP-4 axis in the pathogenesis of chronic low back pain...
April 15, 2024: Spine Journal: Official Journal of the North American Spine Society
#11
JOURNAL ARTICLE
Mary White, Rachel Israilevich, Sophia Lam, Michael McCarthy, Vasil Mico, Benjamin Chipkin, Eric Abrams, Kelly Moore, David Kastenberg
GOALS: We aimed to evaluate whether direct access colonoscopy (DAC) is noninferior to office-scheduled colonoscopy (OSC) for achieving successful colonoscopy. BACKGROUND: DAC may improve access to colonoscopy. We developed an algorithm assessing eligibility, risk for inadequate preparation, and need for nursing/navigator assistance. STUDY: This was a retrospective, single-center study of DAC and OSC patients from June 5, 2018, to July 31, 2019...
April 18, 2024: Journal of Clinical Gastroenterology
#12
JOURNAL ARTICLE
Kavita De, Juan M Belardinelli, Arun Prasad Pandurangan, Teddy Ehianeta, Elena Lian, Zuzana Palčeková, Ha Lam, Mercedes Gonzalez-Juarrero, Josephine M Bryant, Tom L Blundell, Julian Parkhill, R Andres Floto, Todd L Lowary, William H Wheat, Mary Jackson
Mycobacterium abscessus is increasingly recognized as the causative agent of chronic pulmonary infections in humans. One of the genes found to be under strong evolutionary pressure during adaptation of M. abscessus to the human lung is embC which encodes an arabinosyltransferase required for the biosynthesis of the cell envelope lipoglycan, lipoarabinomannan (LAM). To assess the impact of patient-derived embC mutations on the physiology and virulence of M. abscessus , mutations were introduced in the isogenic background of M...
April 23, 2024: Proceedings of the National Academy of Sciences of the United States of America
#13
JOURNAL ARTICLE
Giuseppe P Cortese, Anne Marie W Bartosch, Harrison Xiao, Yelizaveta Gribkova, Tiffany G Lam, Elentina K Argyrousi, Sharanya Sivakumar, Christopher Cardona, Andrew F Teich
ZCCHC17 is a master regulator of synaptic gene expression and has recently been shown to play a role in splicing of neuronal mRNA. We previously showed that ZCCHC17 protein declines in Alzheimer's disease (AD) brain tissue before there is significant gliosis and neuronal loss, that ZCCHC17 loss partially replicates observed splicing abnormalities in AD brain tissue, and that maintenance of ZCCHC17 levels is predicted to support cognitive resilience in AD. Here, we assessed the functional consequences of reduced ZCCHC17 expression in primary cortical neuronal cultures using siRNA knockdown...
April 17, 2024: Journal of Neuropathology and Experimental Neurology
#14
JOURNAL ARTICLE
Cynthia Lam, Alyssa Sargon, Camil Diaz, Zijuan Lai, Dewakar Sangaraju, Inn Yuk, Gavin Barnard, Shahram Misaghi
Chinese hamster ovary (CHO) cells are the predominant host of choice for recombinant monoclonal antibody (mAb) expression. Recent advancements in gene editing technology have enabled engineering new CHO hosts with higher growth, viability, or productivity. One approach involved knock out (KO) of BCAT1 gene, which codes for the first enzyme in the branched chain amino acid (BCAA) catabolism pathway; BCAT1 KO reduced accumulation of growth inhibitory short chain fatty acid (SCFA) byproducts and improved culture growth and titer when used in conjunction with high-end pH-controlled delivery of glucose (HiPDOG) technology and SCFA supplementation during production...
April 17, 2024: Biotechnology Progress
#15
REVIEW
Nancy E Epstein
BACKGROUND: Learning curves (LC) are typically defined by the number of different spinal procedures surgeons must perform before becoming "proficient," as demonstrated by reductions in operative times, estimated blood loss (EBL), length of hospital stay (LOS), adverse events (AE), fewer conversions to open procedures, along with improved outcomes. Reviewing 12 studies revealed LC varied widely from 10-44 cases for open vs. minimally invasive (MI) lumbar diskectomy, laminectomy, transforaminal lumbar interbody fusion (TLIF), anterior lumbar interbody fusion (ALIF), and oblique/extreme lateral interbody fusions (OLIF/XLIF)...
2024: Surgical Neurology International
#16
Koki Mitani, Manabu Minami, Toshiyuki Takahashi, Mariko Toyoda, Ryo Kanematsu, Junya Hanakita
BACKGROUND: Spinal epidural abscess (SEA) is a rare condition that may result in catastrophic outcomes. On the other hand, calcium pyrophosphate (CPP) deposition disease (CPPD) causes inflammatory arthritis. Spinal involvement of a crystal-induced inflammation caused by CPPD is also common. Surgery is a common risk factor for both SEA and CPPD; however, the postoperative acute onset of SEA complicated with CPPD is extremely rare. CASE DESCRIPTION: A man in his 70s presented to our hospital, complaining of right upper limb weakness, loss of dexterity, and gait disturbance...
2024: Surgical Neurology International
#17
Aziz Saade, Hayley M Denwood, Tony Tannoury, Chadi Tannoury
BACKGROUND: Sarcoidosis, a multisystem inflammatory non-caseating granulomatous disease, can present with neurologic lesions in up to 10% of patients. CASE DESCRIPTION: A 57-year-old male presented with three months of worsening upper extremity radicular pain associated with dysmetria, hyperreflexia, bilateral Hoffman's, and positive Babinski signs. The contrast magnetic resonance imaging (MRI) showed a diffuse T2 signal hyperintensity and T1-enhancing 2.5 cm lesion extending sagittally between C4 and C6...
2024: Surgical Neurology International
#18
JOURNAL ARTICLE
Pham Hai Yen, Bui Huu Tai, Dan Thi Thuy Hang, Le Doan Tung Lam, Duong Thi Dung, Do Thi Trang, Duong Thi Hai Yen, Nguyen Huy Hoang, Phan Thi Thanh Huong, Nguyen Viet Dung, Ngo Anh Bang, Nguyen Duc Duy, Phan Van Kiem
In this study, seven new pentacyclic triterpene glycosides, named dendrocinaosides A-G (1-7), and six known ones (8-13) were isolated from the whole plants of Dendrobium officinale . Their structures were determined by analyses of HR-ESI-MS, 1D and 2D NMR spectra. Compounds 1-4, 8, and 9 potentially inhibited α-glucosidase and α-amylase activities with the IC50 values ranging from 31.3 ± 2.2 to 42.4 ± 2.5 μM for anti α-glucosidase and from 36.5 ± 1.8 to 56.4 ± 2.0 μM for anti α-amylase activities, respectively, which were lower than that of the positive control, acarbose, showing IC50 values of 47...
April 10, 2024: RSC Advances
#19
JOURNAL ARTICLE
YongYan Cui, Jose Antonio Almario, Michael Bejjani, Mouen A Khashab, Shayan Irani
Background and study aims Endoscopic ultrasound-directed transgastric intervention (EDGI) is a technique that creates an anastomosis between the gastric pouch or jejunum to the excluded stomach in Roux-en-Y gastric bypass (RYGB) anatomy to allow access to the pancreaticobiliary system. Thus far, management of anastomosis closure at the time of lumen-apposing metal stent (LAMS) removal has varied widely. This study aimed to assess the efficacy of primary closure at the time of LAMS removal using a through-the-scope (TTS) tack-based suture system...
April 2024: Endoscopy International Open
#20
JOURNAL ARTICLE
Silvano S Twinomujuni, Esther C Atukunda, Jackson K Mukonzo, Musinguzi Nicholas, Felicitas Roelofsen, Patrick E Ogwang
BACKGROUND: Initiation of ART among people living with HIV (PLWH) having a CD4 count ≤ 350cells/µl, produces poor immunological recovery, putting them at a high risk of opportunistic infections. To mitigate this, PLWH on ART in Uganda frequently use herbal remedies like Artemisia annua and Moringa oleifera, but their clinical benefits and potential antiretroviral (ARV) interactions remain unknown. This study examined the impact of A. annua and M. oleifera on CD4 count, viral load, and potential ARV interactions among PLWH on ART at an HIV clinic in Uganda...
April 16, 2024: AIDS Research and Therapy
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