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https://www.readbyqxmd.com/read/29223605/updated-european-association-of-urology-guidelines-recommendations-for-the-treatment-of-first-line-metastatic-clear-cell-renal-cancer
#1
REVIEW
Thomas Powles, Laurence Albiges, Michael Staehler, Karim Bensalah, Saeed Dabestani, Rachel H Giles, Fabian Hofmann, Milan Hora, Markus A Kuczyk, Thomas B Lam, Lorenzo Marconi, Axel S Merseburger, Sergio Fernández-Pello, Rana Tahbaz, Alessandro Volpe, Börje Ljungberg, Axel Bex
The randomised phase III clinical trial Checkmate-214 showed a survival superiority for the combination of ipilimumab and nivolumab when compared with the previous standard of care in first-line metastatic/advanced clear cell renal cell carcinoma (RCC) (Escudier B, Tannir NM, McDermott DF, et al. CheckMate 214: efficacy and safety of nivolumab plus ipilimumab vs sunitinib for treatment-naïve advanced or metastatic renal cell carcinoma, including IMDC risk and PD-L1 expression subgroups. LBA5, ESMO 2017, 2017)...
December 6, 2017: European Urology
https://www.readbyqxmd.com/read/29223599/pharmacological-intervention-and-abstinence-in-smokers-undergoing-cessation-treatment-a-psychophysiological-study
#2
Yong Cui, Jeffrey M Engelmann, Jonathan Xian, Jennifer A Minnix, Cho Y Lam, Maher Karam-Hage, Paul M Cinciripini, Jason D Robinson
As a composite concept, negative affect comprises various aversive emotional experiences, such as irritability and nervousness. It is a critical motivational factor that helps maintain smoking behavior, and contributes significantly to smoking cessation failure as a core withdrawal symptom. Prior research has indicated an important role of nicotinic mechanisms in negative affect processing. The most effective smoking cessation medication, varenicline, targets nicotinic acetylcholine receptors (nAChRs) as a partial agonist, while another first-line cessation medication, bupropion, has shown antagonistic effects on nAChRs...
December 6, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29223147/the-unmet-provision-of-allergy-services-in-hong-kong-impairs-capability-for-allergy-prevention-implications-for-the-asia-pacific-region
#3
Tak-Hong Lee, Ting-Fan Leung, Gary Wong, Marco Ho, Jaime Rosa Duque, Philip Hei Li, Chak-Sing Lau, Wai-Fan Lam, Adrian Wu, Eric Chan, Christopher Lai, Yu-Lung Lau
There is a high and rising prevalence of many allergic diseases in the Asia Pacific, including Hong Kong, which is unmatched by a commensurate provision of clinical allergy services. In the last 3 years, the allergy profile in Hong Kong has increased due to greater public engagement and more frequent educational activities, scientific outputs and publication of local guidelines on allergy prevention, diagnosis and treatment. Two new drug allergy clinics have been established in public hospitals, and for the first time in 20 years, Hong Kong has its first trainee in adult allergy...
December 10, 2017: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/29221318/lung-densitometry-why-how-and-when
#4
REVIEW
Mario Mascalchi, Gianna Camiciottoli, Stefano Diciotti
Lung densitometry assesses with computed tomography (CT) the X-ray attenuation of the pulmonary tissue which reflects both the degree of inflation and the structural lung abnormalities implying decreased attenuation, as in emphysema and cystic diseases, or increased attenuation, as in fibrosis. Five reasons justify replacement with lung densitometry of semi-quantitative visual scales used to measure extent and severity of diffuse lung diseases: (I) improved reproducibility; (II) complete vs. discrete assessment of the lung tissue; (III) shorter computation times; (IV) better correlation with pathology quantification of pulmonary emphysema; (V) better or equal correlation with pulmonary function tests (PFT)...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29220578/pd-1-pd-l1-pathway-mediates-the-alleviation-of-pulmonary-fibrosis-by-human-mesenchymal-stem-cells-in-humanized-mice
#5
Ke Ni, Ming Liu, Jian Zheng, Liyan Wen, Qingyun Chen, Zheng Xiang, Kowk-Tai Lam, Yinping Liu, Godfrey Chi-Fung Chan, Yu-Lung Lau, Wenwei Tu
RATIONALE: Pulmonary fibrosis is a chronic progressive lung disease with few treatments. Human mesenchymal stem cells (MSC) have been shown to be beneficial to pulmonary fibrosis as they have the immunomodulatory capacity. However, there is no reliable model to test the therapeutic effect of human MSC in vivo. METHODS: Here, to mimic pulmonary fibrosis in humans, we established a novel bleomycin-induced pulmonary fibrosis model in humanized mice. Based on this model, the benefit of human MSC to pulmonary fibrosis and underlying mechanism were investigated...
December 8, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29220524/brain-responses-to-cigarette-related-and-emotional-images-in-smokers-during-smoking-cessation-no-effect-of-varenicline-or-bupropion-on-the-late-positive-potential
#6
Francesco Versace, Elise M Stevens, Jason D Robinson, Yong Cui, Menton M Deweese, Jeffrey M Engelmann, Charles E Green, Maher Karam-Hage, Cho Y Lam, Jennifer A Minnix, David W Wetter, Paul M Cinciripini
Introduction: Varenicline and bupropion are two effective smoking cessation pharmacotherapies. Researchers have hypothesized that they might be effective, in part, because they reduce cue reactivity and cue-induced cravings. Here, we used event-related potentials (ERPs) to directly measure brain responses to cigarette-related and other motivationally relevant images during a pharmacologically aided quit attempt. Methods: Smokers involved in a 12-week placebo-controlled double-blind clinical trial of smoking cessation medications (varenicline, bupropion, placebo) took part in the study...
December 6, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29220424/genetically-deprived-vitamin-d-exposure-predisposes-to-atrial-fibrillation
#7
Yap-Hang Chan, Kai-Hang Yiu, Jo Jo Hai, Pak-Hei Chan, Tai-Hing Lam, Ben J Cowling, Pak-Chung Sham, Chu-Pak Lau, Karen Siu-Ling Lam, Chung-Wah Siu, Hung-Fat Tse
Aims: Low vitamin D level is associated with atrial fibrillation (AF) and may be implicated in its pathogenesis. Methods and results: We studied single nucleotide polymorphisms (SNPs) of vitamin D mechanistic pathways and serum 25-hydroxyvitamin D [25(OH)D] levels in an age- and gender-matched case-control study (controls without AF: mean age 68.6 ± 8.7 years, female 25%; n = 1019; with AF: mean age 69.7 ± 9.5 years, female 30%; n = 156) recruited from a Chinese clinical cohort of patients with stable coronary artery disease...
December 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29220357/difference-of-the-progression-of-pulmonary-cysts-assessed-by-computed-tomography-among-copd-lymphangioleiomyomatosis-and-birt-hogg-dub%C3%A3-syndrome
#8
Kazunori Tobino, Toyohiro Hirai, Takeshi Johkoh, Kiminori Fujimoto, Atsushi Kawaguchi, Noriyuki Tomiyama, Kazuhisa Takahashi, Kuniaki Seyama
Many groups developed the methods to quantitatively analyze low attenuation area (LAA) on chest CT in patients with cystic lung diseases. Especially in COPD, it was reported that the cumulative size distribution of LAA clusters follows a power law characterized by the exponent D, which reflect the fractal dimension of terminal airspace geometry. We hypoyhesized that the quantitative charateristics of LAA clusters including fractal property might indicate the different features of the progression of cysts in cystic lung diseases...
2017: PloS One
https://www.readbyqxmd.com/read/29220326/a-portable-ultrasound-system-for-non-invasive-ultrasonic-neuro-stimulation
#9
Weibao Qiu, Juan Zhou, Yan Chen, Min Su, Guofeng Li, Huixia Zhao, Xianyi Gu, De Meng, Congzhi Wang, Yang Xiao, Kwok Ho Lam, Jiyan Dai, Hairong Zheng
Fundamental insights into the function of the neural circuits often follows from the advances in methodologies and tools for neuroscience. Electrode- and optical- based stimulation methods have been used widely for neuro-modulation with high resolution. However, they are suffering from inherent invasive surgical procedure. Ultrasound has been proved as a promising technology for neuro-stimulation in a non-invasive manner. However, no portable ultrasound system has been developed particularly for neuro-stimulation...
December 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/29220159/monolithic-nanoporous-in-sn-alloy-for-electrochemical-reduction-of-carbon-dioxide
#10
Wan Jae Dong, Chul Jong Yoo, Jong-Lam Lee
Nanostructured metal catalysts to convert CO2 to formate, which have been extensively studied over decades, have many problems such as durability, lifetime, high process temperature, and difficulty in controlling the morphology of nanostructures. Here, we report a facile method to fabricate monolithic nanoporous In-Sn alloy, a network of nanopores, induced by electroreduction of indium tin oxide nanobranches (ITO BRs). The electroreduction process concentrated a local electric field at the tip of the nanostructure, leading to current-assisted joule-heating to form a nanoporous In-Sn alloy...
December 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29219160/rainbows-supernumerary-rainbows-and-interference-effects-in-the-angular-scattering-of-chemical-reactions-an-investigation-using-heisenberg-s-s-matrix-programme
#11
Xiao Shan, Chengkui Xiahou, J N L Connor
In earlier research, we have demonstrated that broad "hidden" rainbows can occur in the product differential cross sections (DCSs) of state-to-state chemical reactions. Here we ask the question: can pronounced and localized rainbows, rather than broad hidden ones, occur in reactive DCSs? Further motivation comes from recent measurements by H. Pan and K. Liu, J. Phys. Chem. A, 2016, 120, 6712, of a "bulge" in a reactive DCS, which they conjecture is a rainbow. Our theoretical approach uses a "weak" version of Heisenberg's scattering matrix program (wHSMP) introduced by X...
December 8, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29218751/comparing-levels-of-blood-alcohol-concentration-and-indicators-of-impairment-in-nightlife-patrons
#12
Nic Droste, Peter Miller, Christine E Kaestle, Ashlee Curtis, Shannon Hyder, Kerri Coomber, Amy Pennay, Tanya Chikritzhs, Tina Lam, William Gilmore
INTRODUCTION AND AIMS: Breathalyser estimate of blood alcohol concentration (BAC) is widely used as an objective intoxication measure, but is not always practical in nightlife contexts. This study uses in situ data collected in nightlife environments to explore how four measures of intoxication are related so as to inform the development of a more practical and reliable method of differentiating intoxication for people working in the night-time economy. DESIGN AND METHODS: Nightlife patron interviews were conducted in five Australian cities...
December 7, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/29218619/cervical-ultrasonography-has-no-additional-value-over-negative-18f-fdg-pet-ct-scans-for-diagnosing-cervical-lymph-node-metastases-in-patients-with-oesophageal-cancer
#13
Lucas Goense, Jihane Meziani, Peter S N van Rossum, Frank J Wessels, Marnix G E H Lam, Richard van Hillegersberg, Jelle P Ruurda
OBJECTIVES: To investigate the additional value of cervical ultrasonography over 18F-FDG PET/CT for diagnosing cervical lymph node metastases in patients with newly diagnosed oesophageal cancer. METHODS: Between January 2013 and January 2016, 163 patients with newly diagnosed oesophageal cancer underwent both cervical ultrasonography and 18F-FDG PET/CT at a tertiary referral centre in the Netherlands. Retrospective clinical data analysis was performed to assess the diagnostic value of cervical ultrasonography and 18F-FDG PET/CT for the detection of cervical lymph node metastases...
December 7, 2017: European Radiology
https://www.readbyqxmd.com/read/29214586/epidemiology-of-rare-lung-diseases-the-challenges-and-opportunities-to-improve-research-and-knowledge
#14
Cormac McCarthy, Beatriz Lara Gallego, Bruce C Trapnell, Francis X McCormack
Rare lung diseases encompass a broad spectrum of conditions and affect an estimated 1.2-2.5 million people in North America and 1.5-3 million people in Europe. While individual rare lung diseases affect less than 1 in 2000 individuals, collectively they have a significant impact upon the population at large. Hence it is vital to understand firstly the epidemiology and subsequently the pathogenesis and clinical course of these disorders. Through a greater understanding of these aspects of disease, progress can be made in reducing symptoms, containing healthcare costs and utilizing resources efficiently...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29214399/preservation-of-motor-maps-with-increased-motor-evoked-potential-amplitude-threshold-in-rmt-determination
#15
Giuseppe Lucente, Steven Lam, Heike Schneider, Thomas Picht
OBJECTIVE: Non-invasive pre-surgical mapping of eloquent brain areas with navigated transcranial magnetic stimulation (nTMS) is a useful technique linked to the improvement of surgical planning and patient outcomes. The stimulator output intensity and subsequent resting motor threshold determination (rMT) are based on the motor-evoked potential (MEP) elicited in the target muscle with an amplitude above a predetermined threshold of 50 μV. However, a subset of patients is unable to achieve complete relaxation in the target muscles, resulting in false positives that jeopardize mapping validity with conventional MEP determination protocols...
December 6, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29213358/intratumoral-treatment-with-radioactive-beta-emitting-microparticles-a-systematic-review
#16
REVIEW
Robbert C Bakker, Marnix G E H Lam, Sebastiaan A van Nimwegen, Antoine J W P Rosenberg, Robert J J van Es, J Frank W Nijsen
Purpose: The purpose of this study was to review the role of radioactive microparticles (1-100 μm) for the treatment of solid tumors and provide a comprehensive overview of the feasibility, safety, and efficacy. Methods: A systematic search was performed in MEDLINE, EMBASE, and The Cochrane Library (January 2017) by combining synonyms for the determinants "tumor," "injection," and "radionuclide." Data on injection technique, toxicity, tumor response, and survival were collected...
2017: Journal of Radiation Oncology
https://www.readbyqxmd.com/read/29212029/melk-promotes-melanoma-growth-by-stimulating-the-nf-%C3%AE%C2%BAb-pathway
#17
Radoslav Janostiak, Navin Rauniyar, TuKiet T Lam, Jianhong Ou, Lihua J Zhu, Michael R Green, Narendra Wajapeyee
Melanoma accounts for more than 80% of skin cancer-related deaths, and current therapies provide only short-term benefit to patients. Here, we show in melanoma cells that maternal embryonic leucine zipper kinase (MELK) is transcriptionally upregulated by the MAPK pathway via transcription factor E2F1. MELK knockdown or pharmacological inhibition blocked melanoma growth and enhanced the effectiveness of BRAFV600E inhibitor against melanoma cells. To identify mediators of MELK function, we performed stable isotope labeling with amino acids in cell culture (SILAC) and identified 469 proteins that had downregulated phosphorylation after MELK inhibition...
December 5, 2017: Cell Reports
https://www.readbyqxmd.com/read/29211951/a-double-blinded-randomized-study-evaluating-the-in-vivo-effects-of-a-novel-dental-gel-on-enamel-surface-microstructure-and-microhardness
#18
Afarin Golabgir Anbarani, Jessica Ho, Thinh Hung Vu, Ali Forghany, Tracie Lam, Erisa Khashai, Karan Sahni, Thair Takesh, Petra Wilder-Smith
OBJECTIVES: The objective of this study was to evaluate the in vivo effects of a 2.6% edathamil gel (Livionex® Dental Gel) on surface microhardness and microstructure in 180 pre-eroded enamel chips. METHODS: This was a double-blind, randomized study. Two enamel chips each were cut from 90 healthy sterilized extracted teeth. One chip from each pair underwent microhardness testing and scanning electron microscopy (SEM) to establish baselines. The remaining 90 samples were demineralized, and then mounted onto intra-oral retainers worn by nine subjects, with five chips mounted on each retainer for each of the two study arms...
September 2017: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/29211320/consensus-statements-on-the-management-of-metastatic-prostate-cancer-from-the-hong-kong-urological-association-and-hong-kong-society-of-uro-oncology
#19
REVIEW
Darren Ming-Chun Poon, Chi-Kwok Chan, Tim-Wai Chan, Foon-Yiu Cheung, Philip Wai-Kay Kwong, Eric Ka-Chai Lee, Angus Kwong-Chuen Leung, Simon Yiu-Lam Leung, Wai-Kit Ma, Hing-Shing So, Po-Chor Tam, Lap-Yin Ho
OBJECTIVES: To establish a set of consensus statements to facilitate physician management strategies for patients with metastatic prostate cancer (mPC) in Hong Kong. MATERIALS AND METHODS: A local expert consensus was organised jointly by the two main professional organisations representing prostate cancer specialists in Hong Kong. A total of 12 experts were included in the consensus panel. Six of the most crucial and relevant areas of debate regarding the management of mPC were identified...
December 6, 2017: BJU International
https://www.readbyqxmd.com/read/29210978/heterogeneous-data-fusion-method-to-estimate-travel-time-distributions-in-congested-road-networks
#20
Chaoyang Shi, Bi Yu Chen, William H K Lam, Qingquan Li
Travel times in congested urban road networks are highly stochastic. Provision of travel time distribution information, including both mean and variance, can be very useful for travelers to make reliable path choice decisions to ensure higher probability of on-time arrival. To this end, a heterogeneous data fusion method is proposed to estimate travel time distributions by fusing heterogeneous data from point and interval detectors. In the proposed method, link travel time distributions are first estimated from point detector observations...
December 6, 2017: Sensors
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