Ruoyao Qi, Rao Fu, Xing Lei, Jinhang He, Yao Jiang, Liang Zhang, Yangtao Wu, Siling Wang, Xueran Guo, Feng Chen, Meifeng Nie, Man Yang, Yiyi Chen, Jing Zeng, Jingjing Xu, Hualong Xiong, Mujin Fang, Yuqiong Que, Youliang Yao, Yingbin Wang, Jiali Cao, Huiming Ye, Yali Zhang, Zizheng Zheng, Tong Cheng, Jun Zhang, Xu Lin, Quan Yuan, Tianying Zhang, Ningshao Xia
BACKGROUND & AIMS: Mechanisms behind the impaired response of antigen-specific B cells to therapeutic vaccination in chronic hepatitis B virus (HBV) infection remain unclear. The development of vaccines or strategies to overcome this obstacle is vital for advancing the management of chronic hepatitis B. METHODS: A mouse model, denominated as E6F6-B, was engineered to feature a knock-in of a B-cell receptor (BCR) that specifically recognizes HBsAg. This model served as a valuable tool for investigating the temporal and spatial dynamics of humoral responses following therapeutic vaccination under continuous antigen exposure...
February 7, 2024: Journal of Hepatology