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https://www.readbyqxmd.com/read/28944945/safety-and-efficacy-of-ventriculostomy-procedures-under-dual-antiplatelet-therapy-in-patients-treated-with-stent-assisted-coiling-in-subarachnoid-hemorrhage
#1
Soner Civi, Cagatay Andic, Ozgur Kardes, Halil İbrahim Suner, Emre Durdag, Ozlem Ozmete, Kadir Tufan
AIM: Stent assisted coilling (SAC) is an alternative in the treatment of ruptured aneurysms. Stenting requires the use of dual antiplatelet agents. Hydrocephaly is a complication of subarachnoid hemorrhage (SAH) requiring ventriculostomy. Antiplatelet treatment reveal a risk of hemorrhage in ventriculostomy. Anti-aggregant effect starts at least four hours after the initial doses of treatment. However, in many studies, ventriculostomy was performed before antiplatelet treatment and the hemorrhagic complications were related to the procedure...
July 16, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28941176/optimized-human-platelet-lysate-as-novel-basis-for-a-serum-xeno-and-additive-free-corneal-endothelial-cell-and-tissue-culture
#2
Daniel Thieme, Lynn Reuland, Toni Lindl, Friedrich Kruse, Thomas Fuchsluger
INTRODUCTION: The expansion of donor derived corneal endothelial cells is a promising approach for regenerative therapies in corneal diseases. To achieve the best GMP standard the entire cultivation process should be devoid of non-human components. However, so far there is no suitable xeno-free protocol for clinical applications. METHODS: We therefore introduce a processed variant of a platelet lysate for the use in corneal cell and tissue culture based on a GMP-grade thrombocyte concentrate...
September 21, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28939876/thrombopoietic-stimulating-activity-of-rhtyrrs-y341a
#3
Yu Jinchao, Zhang Yanling, Wang Xu, Zhao Bing, Ye Yuhao, Zhou Weiran, Sun Shaoyang, Ma Liyun, Shi Yun, Zhan Ling, Yu Min, Mo Wei
Tumor radiotherapy induces hematopoietic organ damage and reduces thrombocyte counts. Thrombocytopenia is a common disease. Some studies have shown that tRNA synthetase plays not only catalytic tRNA aminoacylation roles, but also functions similarly to cytokines. Recombinant human tyrosyl-tRNA synthetase with a mutated Y341A (rhTyrRS (Y341A)) promotes megakaryocyte migrate from bone marrow to peripheral blood. It would promote megakaryocytes in the lungs adhering to vascular endothelial cells and resulting in the platelet production...
September 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28931468/platelet-released-growth-factors-inhibit-proliferation-of-primary-keratinocytes-in-vitro
#4
Andreas Bayer, Mersedeh Tohidnezhad, Rouven Berndt, Sebastian Lippross, Peter Behrendt, Tim Klüter, Thomas Pufe, Holger Jahr, Jochen Cremer, Franziska Rademacher, Maren Simanski, Regine Gläser, Jürgen Harder
Autologous thrombocyte concentrate lysates as platelet-released growth factors (PRGF) or Vivostat Platelet Rich Fibrin (PRF(®)) represent important tools in modern wound therapy, especially in the treatment of chronic, hard-to-heal or infected wounds. Nevertheless, underlying cellular and molecular mechanisms of the beneficial clinical effects of a local wound therapy with autologous thrombocyte concentrate lysates are poorly understood. Recently, we have demonstrated that PRGF induces antimicrobial peptides in primary keratinocytes and accelerates keratinocytes' differentiation...
September 18, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28905099/port-implantation-in-patients-with-severe-thrombocytopenia-is-safe-with-interventional-radiology
#5
Annika R Keulers, Lilian Kiesow, Andreas H Mahnken
PURPOSE: Platelet counts <50/nl are often considered a contraindication for surgical and interventional radiology procedures. Yet, there are patients requiring totally implantable venous access ports (TIVAP) in whom normalization of the coagulation state is not feasible. This retrospective study evaluates the safety of interventional radiological TIVAP implantation in patients with severe thrombocytopenia. MATERIALS AND METHODS: From 12/2010 to 12/2014, a total 1200 consecutive radiological TIVAP implantations were performed and retrospectively analyzed...
September 13, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28899852/identification-of-extant-vertebrate-myxine-glutinosa-vwf-evolutionary-conservation-of-primary-hemostasis
#6
Marianne A Grant, David L Beeler, Katherine C Spokes, Junmei Chen, Harita Dharaneeswaran, Tracey E Sciuto, Ann M Dvorak, Gianluca Interlandi, José A Lopez, William C Aird
Hemostasis in vertebrates involves both a cellular and protein component. Previous studies in jawless vertebrates (cyclostomes) suggest that the protein response, which involves thrombin-catalyzed conversion of a soluble plasma protein, fibrinogen, into a polymeric fibrin clot, is conserved in all vertebrates. However, similar data are lacking for the cellular response, which in gnathostomes, is regulated by von Willebrand factor (VWF), a glycoprotein that mediates the adhesion of platelets to the subendothelial matrix of injured blood vessels...
September 12, 2017: Blood
https://www.readbyqxmd.com/read/28858379/hematologic-reference-intervals-for-wild-black-vultures-coragyps-atratus
#7
Jean C A Barbara, Vivian L Ferreira, Fernanda J V Guida, Fabíola E S Prioste, Eliana R Matushima, Tânia F Raso
BACKGROUND: The Black vulture (Coragyps atratus) is the most common species of vulture and is widespread in all America. The species feeds on rotting carcasses, and large groups are frequently seen in urban areas, concentrating especially on rubbish dumps. Although C atratus is a very common species in some areas, little is known about its health in the wild. OBJECTIVES: The aim of this study was to determine hematologic RIs of wild adult Black vultures. METHODS: Blood samples were obtained from 70 wild Black vultures captured in São Paulo, Brazil...
August 31, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28858128/percutaneous-transhepatic-papilla-balloon-dilatation-combined-with-a-percutaneous-transcystic-approach-for-removing-concurrent-gallbladder-stone-and-common-bile-duct-stone-in-a-patient-with-billroth-ii-gastrectomy-and-acute-cholecystitis-a-case-report
#8
Dong Li, Yu-Liang Li, Wu-Jie Wang, Bin Liu, Hai-Yang Chang, Wei Wang, Yong-Zheng Wang, Zheng Li
BACKGROUND: A 61-year-old man presented with upper abdominal pain and jaundice. Abdominal computed tomography imaging revealed stones in the gallbladder and the common bile duct, with a thickening of the gallbladder wall and an obvious increase in the volume of the gallbladder. Initial treatment using endoscopic retrograde cholangiopancreatography failed due to the presence of surgically altered gastrointestinal anatomy. Stones in the gallbladder and common bile duct were subsequently removed concurrently via percutaneous transhepatic papilla balloon dilatation combined with a percutaneous transcystic approach...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28845088/platelet-rich-plasma-as-an-autologous-and-proangiogenic-cell-delivery-system
#9
Jessica Zahn, Markus Loibl, Christoph Sprecher, Michael Nerlich, Mauro Alini, Sophie Verrier, Marietta Herrmann
Angiogenesis is a key factor in early stages of wound healing and is crucial for the repair of vascularized tissues such as the bone. However, supporting timely revascularization of the defect site still presents a clinical challenge. Tissue engineering approaches delivering endothelial cells or prevascularized constructs may overcome this problem. In the current study, we investigated platelet-rich plasma (PRP) gels as autologous, injectable cell delivery systems for prevascularized constructs. PRP was produced from human thrombocyte concentrates...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28842181/splenic-%C3%AE-%C3%AE-t-cell-subsets-can-be-separated-by-a-novel-mab-specific-for-two-cd45-isoforms
#10
Daniela Huhle, Sieglinde Hirmer, Thomas W Göbel
CD45 isoforms have been identified in a variety of different species and mab against various isoforms have been instrumental to define cellular subsets. In the process of generating novel mab against chicken γδ T cells two mab with specificity for CD45 were identified and characterized. The analysis of the chicken CD45 genomic structure suggested three exons being involved in alternative splicing. We cloned and expressed the full length CD45 isoform and three shorter isoforms. While the 7D12 mab reacted with all of these isoforms, the 8B1 mab selectively reacted with two short isoforms lacking either exons 3 and 5 or exons 3, 5 and 6...
August 24, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28836477/antithrombocytopenic-and-immunomodulatory-potential-of-metabolically-characterized-aqueous-extract-of-carica-papaya-leaves
#11
Varisha Anjum, Poonam Arora, Shahid Husain Ansari, Abul Kalam Najmi, Sayeed Ahmad
CONTEXT: Carica papaya Linn. (Caricaceae) leaf (CPL) juice has long been traditionally used in ethnomedicine for dengue fever. OBJECTIVE: The study examines the effects of standardized CPL aqueous extract (SCPLE) on platelet count, extramedullary haematopoiesis (EMH), and immunomodulation in cyclophosphamide (CP)-induced animal model of thrombocytopenia. MATERIALS AND METHODS: The extract was analyzed for myricetin, caffeic acid, trans-ferulic acid, and kaempferol using HPTLC for standardization followed by UPLC-qTOF/MS fingerprinting for metabolite signature...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28821815/epac1-deficient-mice-have-bleeding-phenotype-and-thrombocytes-with-decreased-gpib%C3%AE-expression
#12
Gyrid Nygaard, Lars Herfindal, Kathrine S Asrud, Ronja Bjørnstad, Reidun K Kopperud, Eystein Oveland, Frode S Berven, Lene Myhren, Erling A Hoivik, Turid Helen Felli Lunde, Marit Bakke, Stein O Døskeland, Frode Selheim
Epac1 (Exchange protein directly activated by cAMP 1) limits fluid loss from the circulation by tightening the endothelial barrier. We show here that Epac1(-/-) mice, but not Epac2(-/-) mice, have prolonged bleeding time, suggesting that Epac1 may limit fluid loss also by restraining bleeding. The Epac1(-/-) mice had deficient in vitro secondary hemostasis. Quantitative comprehensive proteomics analysis revealed that Epac1(-/-) mouse platelets (thrombocytes) had unbalanced expression of key components of the glycoprotein Ib-IX-V (GPIb-IX-V) complex, with decrease of GP1bβ and no change of GP1bα...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28817693/clinical-signs-profound-acidemia-hypoglycemia-and-hypernatremia-are-predictive-of-mortality-in-1-400-critically-ill-neonatal-calves-with-diarrhea
#13
Florian M Trefz, Ingrid Lorenz, Annette Lorch, Peter D Constable
Profound acidemia impairs cellular and organ function and consequently should be associated with an increased risk of mortality in critically ill humans and animals. Neonatal diarrhea in calves can result in potentially serious metabolic derangements including profound acidemia due to strong ion (metabolic) acidosis, hyper-D-lactatemia, hyper-L-lactatemia, azotemia, hypoglycemia, hyperkalemia and hyponatremia. The aim of this retrospective study was to assess the prognostic relevance of clinical and laboratory findings in 1,400 critically ill neonatal calves with diarrhea admitted to a veterinary teaching hospital...
2017: PloS One
https://www.readbyqxmd.com/read/28811680/the-antimicrobial-peptide-human-beta-defensin-3-is-induced-by-platelet-released-growth-factors-in-primary-keratinocytes
#14
Andreas Bayer, Justus Lammel, Mersedeh Tohidnezhad, Sebastian Lippross, Peter Behrendt, Tim Klüter, Thomas Pufe, Jochen Cremer, Holger Jahr, Franziska Rademacher, Regine Gläser, Jürgen Harder
Platelet-released growth factors (PRGF) and its related clinically used formulations (e.g., Vivostat Platelet-Rich Fibrin (PRF®)) contain a variety of chemokines, cytokines, and growth factors and are therefore used to support healing of chronic, hard-to-heal, or infected wounds. Human beta-defensin-3 (hBD-3) is an antimicrobial peptide inducibly expressed in human keratinocytes especially upon wounding. The potent antimicrobial activity of hBD-3 together with its wound closure-promoting activities suggests that hBD-3 may play a crucial role in wound healing...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28808357/platelet-released-growth-factors-induce-differentiation-of-primary-keratinocytes
#15
Andreas Bayer, Mersedeh Tohidnezhad, Justus Lammel, Sebastian Lippross, Peter Behrendt, Tim Klüter, Thomas Pufe, Holger Jahr, Jochen Cremer, Franziska Rademacher, Regine Gläser, Jürgen Harder
Autologous thrombocyte concentrate lysates, for example, platelet-released growth factors, (PRGFs) or their clinically related formulations (e.g., Vivostat PRF®) came recently into the physicians' focus as they revealed promising effects in regenerative and reparative medicine such as the support of healing of chronic wounds. To elucidate the underlying mechanisms, we analyzed the influence of PRGF and Vivostat PRF on human keratinocyte differentiation in vitro and on epidermal differentiation status of skin wounds in vivo...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28802564/interactions-between-platelets-and-inflammatory-monocytes-affect-sickness-behavior-in-mice-with-liver-inflammation
#16
Charlotte D'Mello, Wagdi Almishri, Hongqun Liu, Mark Gordon Swain
BACKGROUND & AIMS: Patients with inflammatory liver disease commonly develop debilitating symptoms, called sickness behaviors, which arise via changes in brain function. Monocytes that produce tumor necrosis factor (TNF) interact with cerebral endothelial cells to activate microglial cells and promote sickness behavior. Platelets regulate inflammation, and aggregates of monocytes and platelets are increased in the circulation of patients with liver disease. We investigated the role of platelets in inducing inflammatory features of circulating monocytes and promoting sickness behaviors in mice with cholestatic liver injury...
August 9, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28800376/fetal-bovine-serum-fbs-past-present-future
#17
Jan van der Valk, Karen Bieback, Christiane Buta, Brett Cochrane, Wilhelm G Dirks, Jianan Fu, James J Hickman, Christiane Hohensee, Roman Kolar, Manfred Liebsch, Francesca Pistollato, Markus Schulz, Daniel Thieme, Tilo Weber, Joachim Wiest, Stefan Winkler, Gerhard Gstraunthaler
The supplementation of culture medium with fetal bovine serum (FBS, also referred to as 'fetal calf serum') is still common practice in cell culture applications. Due to a number of disadvantages in terms of quality and reproducibility of in vitro data, animal welfare concerns, and in light of recent cases of fraudulent marketing, the search for alternatives and the development of serum-free medium formulations gained global attention. Here, we report on the 3rd Workshop on FBS, Serum Alternatives and Serum-free Media, where (a) regulatory aspects, (b) the serum dilemma, (c) alternatives to FBS, (d) case-studies of serum-free in vitro applications, and (e) the establishment of serum-free databases, were discussed...
August 9, 2017: ALTEX
https://www.readbyqxmd.com/read/28783866/hematologic-and-plasma-chemistry-ris-for-cultured-striped-catfish-pangasius-hypophthalmus-in-recirculating-aquaculture-systems
#18
Oscar A Galagarza, David D Kuhn, Stephen A Smith, Terry C Hrubec
BACKGROUND: Striped catfish (Pangasius hypophthalmus) is a valuable aquaculture fish species produced primarily in Southeast Asia. In the United States, it is bred as an ornamental species. Striped catfish has high productivity and great demand in numerous countries around the world, yet little is known about its normal physiology. OBJECTIVES: The objective of this study was to establish hematologic and blood chemistry RIs for healthy juvenile Striped catfish. METHODS: Blood samples were collected from 70 Striped catfish raised in recirculating aquaculture systems...
August 7, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28781130/cardiac-function-improvement-and-bone-marrow-response-outcome-analysis-of-the-randomized-perfect-phase-iii-clinical-trial-of-intramyocardial-cd133-application-after-myocardial-infarction
#19
Gustav Steinhoff, Julia Nesteruk, Markus Wolfien, Günther Kundt, Jochen Börgermann, Robert David, Jens Garbade, Jana Große, Axel Haverich, Holger Hennig, Alexander Kaminski, Joachim Lotz, Friedrich-Wilhelm Mohr, Paula Müller, Robert Oostendorp, Ulrike Ruch, Samir Sarikouch, Anna Skorska, Christof Stamm, Gudrun Tiedemann, Florian Mathias Wagner, Olaf Wolkenhauer
OBJECTIVE: The phase III clinical trial PERFECT was designed to assess clinical safety and efficacy of intramyocardial CD133(+) bone marrow stem cell treatment combined with CABG for induction of cardiac repair. DESIGN: Multicentre, double-blinded, randomised placebo controlled trial. SETTING: The study was conducted across six centres in Germany October 2009 through March 2016 and stopped due slow recruitment after positive interim analysis in March 2015...
August 2017: EBioMedicine
https://www.readbyqxmd.com/read/28776204/efficacy-and-safety-of-argatroban-in-patients-with-acute-respiratory-distress-syndrome-and-extracorporeal-lung-support
#20
Mario Menk, Philipp Briem, Björn Weiss, Martina Gassner, David Schwaiberger, Anton Goldmann, Christian Pille, Steffen Weber-Carstens
BACKGROUND: Extracorporeal membrane oxygenation (ECMO) or pumpless extracorporeal lung assist (pECLA) requires effective anticoagulation. Knowledge on the use of argatroban in patients with acute respiratory distress syndrome (ARDS) undergoing ECMO or pECLA is limited. Therefore, this study assessed the feasibility, efficacy and safety of argatroban in critically ill ARDS patients undergoing extracorporeal lung support. METHODS: This retrospective analysis included ARDS patients on extracorporeal lung support who received argatroban between 2007 and 2014 in a single ARDS referral center...
December 2017: Annals of Intensive Care
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