keyword
MENU ▼
Read by QxMD icon Read
search

thrombocytes

keyword
https://www.readbyqxmd.com/read/28533941/changes-in-clinical-laboratory-parameters-and-pharmacodynamic-markers-in-response-to-blinatumomab-treatment-of-patients-with-relapsed-refractory-all
#1
Virginie Nägele, Andrea Kratzer, Gerhard Zugmaier, Chris Holland, Youssef Hijazi, Max S Topp, Nicola Gökbuget, Patrick A Baeuerle, Peter Kufer, Andreas Wolf, Matthias Klinger
BACKGROUND: Blinatumomab has shown a remission rate of 69% in an exploratory single-arm, phase II dose-escalation study in adult patients with relapsed/refractory B-precursor acute lymphoblastic leukemia (ALL). We evaluated changes in laboratory parameters and immunopharmacodynamic markers in patients who received blinatumomab in the exploratory phase II study. METHODS: Data from 36 adults with relapsed/refractory ALL receiving blinatumomab as 4-week continuous IV infusions in various dose cohorts were analyzed for changes in liver enzymes, first-dose parameters, peripheral blood cell subpopulations, and cytokine/granzyme B release...
2017: Experimental Hematology & Oncology
https://www.readbyqxmd.com/read/28528516/combined-effects-of-chinese-medicine-feed-and-ginger-extract-bath-on-co-infection-of-ichthyophthirius-multifiliis-and-dactylogyrus-ctenopharyngodonid-in-grass-carp
#2
Yao-Wu Fu, Bin Wang, Qi-Zhong Zhang, De-Hai Xu, De-Jie Lin, Xing-Ya Yang, Shu-Qun Zhu, Jing-Yang Pan, Qian Deng, Yan-Meng Liu, Sheng-Yu Zhou
Dactylogyrus ctenopharyngodonid and Ichthyophthirius multifiliis are two important ectoparasites of freshwater fish. Co-infection by the two parasites leads to high fish mortality and results in heavy economic losses. This study aimed to evaluate the efficacy of medicated feed and a ginger extract bath against D. ctenopharyngodonid and I. multifiliis on grass carp and investigate the hematological response of grass carp co-infected by the two parasites. These results demonstrated that red blood cell (RBC) and thrombocyte percentage among leucocytes significantly decreased after grass carp were co-infected by D...
May 20, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28507372/medicinal-role-of-papaya-seeds-on-thrombocyte-count-tested-on-healthy-rabbits
#3
Asif Ahmed, Farhat Jehan
The main objective of the current study is to evaluate the medicinal role of Papaya seeds on thrombocyte count and hepatic parameter on healthy rabbits. Experimental and Interventional study, at the Department of pharmacology Baqai Medical University Karachi. Rabbits (18 in number different age and both sex) were included, subsequently subdivided into three group (n=6). Group A (Control), B and C (sample fed dose 250 & 500mg OD, oral route). Blood were drawn 0 time, subsequently samples were drawn at 15, 30, 45 days...
May 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28491434/life-threatening-haematological-complication-occurring-in-a-cat-after-chronic-carbimazole-administration
#4
Andrea Mosca, Luca Bresciani
CASE SUMMARY: An 11-year-old spayed female domestic shorthair cat with a history of hyperthyroidism treated with carbimazole for 7 months was presented for a check-up after a few episodes of vomiting. The cat had been receiving prednisolone at 0.5 mg/kg PO q12h for recent pancreatitis and concurrent inflammation of liver and small intestines confirmed by biopsies. Clinical examination revealed pale mucous membranes with a capillary refill time of <2 s. Haematology showed severely decreased packed cell volume (16%), and increased prothrombin time (42 s), partial thromboplastin time (>120 s) and fibrinogen serum concentration (3...
July 2016: JFMS Open Rep
https://www.readbyqxmd.com/read/28480552/hyperfibrinolysis-and-hypofibrinogenemia-diagnosed-with-rotational-thromboelastometry-in-dogs-naturally-infected-with-angiostrongylus-vasorum
#5
N E Sigrist, N Hofer-Inteeworn, R Jud Schefer, C Kuemmerle-Fraune, M Schnyder, A P N Kutter
BACKGROUND: The pathomechanism of Angiostrongylus vasorum infection-associated bleeding diathesis in dogs is not fully understood. OBJECTIVE: To describe rotational thromboelastometry (ROTEM) parameters in dogs naturally infected with A. vasorum and to compare ROTEM parameters between infected dogs with and without clinical signs of bleeding. ANIMALS: A total of 21 dogs presented between 2013 and 2016. METHODS: Dogs with A...
May 7, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28473690/clinical-and-laboratory-features-of-cd5-negative-chronic-lymphocytic-leukemia
#6
Cengiz Demir, Erdal Kara, Ömer Ekinci, Senar Ebinç
BACKGROUND Chronic lymphocytic leukemia (CLL) usually expresses CD5 antigen. However, 7-20% of patients are CD5 negative. We report here a series of 19 CD5-negative B-CLL cases. MATERIAL AND METHODS We reviewed 19 consecutive CD5-negative B-CLL cases seen in our medical center from 2009 to 2015 and compared them with 105 CD5-positive B-CLL cases. The two groups were compared in terms of clinical parameters, laboratory parameters, and survival characteristics. RESULTS Lymphadenopathy was present in 31.5% of the CD5-negative group and 51...
May 5, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28471730/a-vegetable-launaea-taraxacifolia-mitigated-mercuric-chloride-alteration-of-the-microanatomy-of-rat-brain
#7
Olatunde Owoeye, Ganiyu O Arinola
Mercuric chloride is an environmental pollutant that affects the nervous systems of mammals. Oxidative damage is one of the mechanisms of its toxicity, and antioxidants should mitigate this effect. A vegetable with antioxidant activity is Launaea taraxacifolia, whose ethanolic extract (EELT) was investigated in this experiment to determine its effect against mercuric chloride (MC) intoxication in rat brain. Thirty male Wistar rats were randomly assigned into five groups (n = 6) as follows: control; propylene glycol; EELT (400 mg/kg bwt) for 19 days; MC (HgCl2) (4 mg/bwt) for 5 days from day 15 of the experiment; EELT+ MC, EELT (400 mg/kg bwt) for 14 days + MC (4 mg/bwt) for 5 days from day 15 of the experiment...
November 2, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28456898/predictive-value-of-early-skin-rash-in-cetuximab-based-therapy-of-advanced-biliary-tract-cancer
#8
Gábor Rubovszky, Barna Budai, Erna Ganofszky, Zsolt Horváth, Éva Juhos, Balázs Madaras, Tünde Nagy, Eszter Szabó, Tamás Pintér, Erika Tóth, Péter Nagy, István Láng, Erika Hitre
Randomized trials in advanced biliary tract cancer (BTC) did not show benefit of cetuximab addition over chemotherapy. This is probably due to the lack of predictive biomarkers. The aim of this study was to explore possible predictive factors. Between 2009 and 2014, 57 patients were treated in 3-week cycles with cetuximab (250 mg/m(2)/week, loading dose: 400 mg/m(2)), gemcitabine (1000 mg/m(2) on day 1 and 8), and capecitabine (1300 mg/m(2)/day on days 1-14). The objective response rate (ORR), progression-free (PFS) and overall survival (OS) and the adverse events (AEs) were evaluated...
April 29, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28433719/isolation-and-characterization-of-monocyte-macrophage-from-peripheral-blood-of-half-smooth-tongue-sole-cynoglossus-semilaevis
#9
Zhenxia Sha, Linqing Wang, Luming Sun, Yadong Chen, Yuan Zheng, Mei Xin, Chen Li, Songlin Chen
In the present study, the peripheral blood cells of half smooth tongue sole (Cynoglossus semilaevis) were examined by blood smear under the light microscopy. The proportion of main types of blood cells are as following: erythrocyte occupied the majority (92.3%), followed by thrombocyte (4.15%), granulocyte (1.7%), lymphocyte (1.5%) and monocyte (0.3%), respectively. Meanwhile, the isolation method of monocytes was established, by density gradient centrifugation to isolate mononuclear leukocytes of peripheral blood...
April 19, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28408792/thrombopoietin-receptor-agonist-mitigates-hematopoietic-radiation-syndrome-and-improves-survival-after-whole-body-ionizing-irradiation-followed-by-wound-trauma
#10
Juliann G Kiang, Min Zhai, Pei-Jun Liao, Connie Ho, Nikolai V Gorbunov, Thomas B Elliott
Ionizing radiation combined with trauma tissue injury (combined injury, CI) results in greater mortality and H-ARS than radiation alone (radiation injury, RI), which includes thrombocytopenia. The aim of this study was to determine whether increases in numbers of thrombocytes would improve survival and mitigate H-ARS after CI. We observed in mice that WBC and platelets remained very low in surviving RI animals that were given 9.5 Gy (60)Co-γ-photon radiation, whereas only lymphocytes and basophils remained low in surviving CI mice that were irradiated and then given skin wounds...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28393731/moxifloxacin-related-thrombocytopeniae-a-case-report
#11
Mustafa Çörtük, Ali Ramazan Benli, Mustafa Köroğlu, Onur Yazıcı, Murat Acat, Hasan Casim, Erdoğan Çetinkaya
Drug-induced thrombocytopenia can be caused by various medications, most frequently, antibiotics. There have been reports of thrombocytopenia cases due to the usage of quinolone antibiotics, although moxifloxacin-related thrombocytopenia has been reported very rarely. The case is here presented of a 60-year old male with chronic obstructive pulmonary disease who presented with complaints of progressively worsening dyspnea. After hospitalization, progressive thrombocytopenia was detected which had started on the 3rd day of moxifloxacin treatment...
September 2016: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/28387829/hereditary-polycystic-kidney-disease-is-characterized-by-lymphopenia-across-all-stages-of-kidney-dysfunction-an-observational-study
#12
Steven Van Laecke, Tessa Kerre, Evi V Nagler, Bart Maes, Rogier Caluwe, Eva Schepers, Griet Glorieux, Wim Van Biesen, Francis Verbeke
Background: Polycystic kidney disease (PKD) is characterized by urinary tract infections and extrarenal abnormalities such as an increased risk of cancer. As mutations in polycystin-1 and -2 are associated with decreased proliferation of immortalized lymphoblastoid cells in PKD, we investigated whether lymphopenia could be an unrecognized trait of PKD. Methods: We studied 700 kidney transplant recipients with ( n  = 126) or without PKD at the time of kidney transplantation between 1 January 2003 and 31 December 2014 at Ghent University Hospital...
April 6, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28379034/lipoprotein-apheresis-in-the-treatment-of-dyslipidaemia-the-czech-republic-experience
#13
V Bláha, M Bláha, M Lánská, D Solichová, L Kujovská Krčmová, E Havel, P Vyroubal, Z Zadák, P Žák, L Sobotka
In 1984, we started using therapeutic plasmapheresis (plasma exchange) as a method of extracorporeal lipoprotein elimination for the treatment of hypercholesterolemic patients. We evaluated the results of long-term therapy in 14 patients, 8 men and 6 women. The average age was 55.6+/-13.2 (range 28-70), median 59.5 years. 14 patients were diagnosed with familial hypercholesterolemia (FH): 5 homozygous, 9 heterozygous. Ten patients in the group were treated using immunoadsorption lipoprotein apheresis and 4 using hemorheopheresis...
April 5, 2017: Physiological Research
https://www.readbyqxmd.com/read/28376758/the-value-of-applying-a-melatonin-antagonist-luzindole-in-improving-the-success-rate-of-the-bipedal-rat-scoliosis-model
#14
Shuo Yang, Chaojun Zheng, Jianyuan Jiang, Feizhou Lu, Xinlei Xia, Wei Zhu, Xiang Jin, Xiaosheng Ma
BACKGROUND: An ideal animal model has always been the key to research the pathogenesis and treatment of adolescent idiopathic scoliosis (AIS), while available methods have obvious disadvantages. The deficiency of melatonin has been proved relating to AIS. In this research, we intended to apply Luzindole, the melatonin antagonist, in bipedal rat model, for the block of combination of melatonin and its receptor, to inhibit the melatonin effect, and then to understand whether this method can effectively improve the scoliosis rate of bipedal rat model, and investigate the role of melatonin in scoliosis...
April 4, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28366160/-moxifloxacin-related-thrombocytopeniae-a-case-report
#15
Mustafa Çörtük, Ali Ramazan Benli, Mustafa Köroğlu, Onur Yazıcı, Murat Acat, Hasan Casim, Erdoğan Çetinkaya
Drug-induced thrombocytopenia can be caused by various medications, most frequently, antibiotics. There have been reports of thrombocytopenia cases due to the usage of quinolone antibiotics, although moxifloxacin-related thrombocytopenia has been reported very rarely. The case is here presented of a 60-year old male with chronic obstructive pulmonary disease who presented with complaints of progressively worsening dyspnea. After hospitalization, progressive thrombocytopenia was detected which had started on the 3rd day of moxifloxacin treatment...
September 2016: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/28364184/etiology-and-clinical-relevance-of-elevated-platelet-count-in-icu-patients-a%C3%A2-retrospective-analysis
#16
M Banach, C Lautenschläger, P Kellner, J Soukup
BACKGROUND: Thrombocytosis is a common phenomenon in critically ill patients. Although thrombocytosis is an independent risk factor for complications, it does not seem to influence mortality in intensive care (ICU) patients. OBJECTIVES: Our investigation aimed to evaluate the etiological and clinical relevance of a platelet count greater than 450 × 10(9)/l in ICU patients. MATERIALS AND METHODS: Patients admitted for a minimum of 4 days to an interdisciplinary ICU during a 45-month period were enrolled in this retrospective observational study...
March 31, 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/28353134/ontogeny-of-ramified-cd45-cells-in-chicken-embryo-and-their-contribution-to-bursal-secretory-dendritic-cells
#17
Dávid Dóra, Nóra Fejszák, Allan M Goldstein, Krisztina Minkó, Nándor Nagy
Embryonic tissues contain highly ramified stellate-shaped cells expressing CD45 and MHC II antigens but their origin and immunophenotype are unknown. Using staged avian embryos and cell-type-specific antibodies, we establish a detailed spatiotemporal ontogeny of cells that express CD45, the earliest marker of hematopoietic stem cells in the chick. CD45 immunostaining marks three distinct embryonic cell populations: round, ramified and amoeboid cells. The round and ramified CD45+ cells appear first in yolk-sac blood islands before the onset of circulation...
March 28, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28350995/the-difference-in-association-between-aspirin-use-and-other-thrombocyte-aggregation-inhibitors-and-survival-in-patients-with-colorectal-cancer
#18
M A Frouws, E Rademaker, E Bastiaannet, M P P van Herk-Sukel, V E Lemmens, C J H Van de Velde, J E A Portielje, G J Liefers
BACKGROUND: Several studies have suggested that the association between aspirin and improved cancer survival is mediated through the mechanism of aspirin as thrombocyte aggregation inhibitors (TAI). The aim of this study was to provide epidemiological evidence for this mechanism assessing the association between overall survival and the use of aspirin and non-aspirin TAI in patients with colorectal cancer. METHODS: In this observational study, data from the Netherlands Comprehensive Cancer Organisation were linked to PHARMO Database Network...
March 25, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28344171/lipopolysaccharide-induced-interleukin-6-production-is-mediated-through-activation-of-erk-1-2-p38-mapk-mek-and-nf%C3%AE%C2%BAb-in-chicken-thrombocytes
#19
C Winkler, F Ferdous, M Dimmick, T Scott
Thrombocytes express Toll-like receptor 4 and apparently use both mitogen-activated protein kinase (MAPK) and nuclear factor kappa-light-chain-enhancer of activated B cells (NFKB) pathways for nuclear signaling. However, it is not well known if the same enzyme systems found in mammalian cells are fully functional in chickens. Therefore, kinase inhibitors were used with thrombocytes to block kinases in lipopolysaccharide (LPS) stimulated cells to determine if interleukin (IL)-6 expression and production would be diminished...
March 23, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28341399/early-postoperative-blood-pressure-and-blood-loss-after-cardiac-surgery-a-retrospective-analysis
#20
Cagla Demirci, Florian Zeman, Christof Schmid, Bernhard Floerchinger
BACKGROUND: Increased blood loss after cardiac surgery is a risk factor for patient morbidity and mortality. Guidelines for postoperative haemodynamics management recommend normotensive blood pressure to avoid increased chest drain volumes. The aim of this study was to verify the correlation of early postoperative hypertension and blood loss in patients after cardiac surgery during the early postoperative period. METHODS: Postoperative mean blood pressure values and chest drain volumes of 431 patients were registered by an intensive care monitoring system during first 60minutes after intensive care admission...
March 22, 2017: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
keyword
keyword
42770
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"