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https://www.readbyqxmd.com/read/29694831/atorvastatin-in-nano-particulate-formulation-abates-muscle-and-liver-affliction-when-coalesced-with-coenzyme-q10-and-or-vitamin-e-in-hyperlipidemic-rats
#1
S M Farrag, M A Hamzawy, M F El-Yamany, M A Saad, N N Nassar
AIMS: Statins are the most widely used to lower elevated low-density lipoprotein levels and preventing cardiovascular diseases in humans. However, about 20% of patients treated with this medication suffer from statin-related myalgia. To this end, this study investigated the potential effect of nano-particulate formulation in alleviating the muscles and liver damage either alone or when co-administered with nano coenzyme Q10 and nano vitamin E. MATERIALS AND METHODS: Male Wistar rats were fed normal diet or high-fat diet for 12 weeks, following which rats were treated with either (i) atorvastatin (5 or 20 mg/kg/day, p...
April 22, 2018: Life Sciences
https://www.readbyqxmd.com/read/29694393/replacement-of-fish-oil-with-palm-oil-effects-on-growth-performance-innate-immune-response-antioxidant-capacity-and-disease-resistance-in-nile-tilapia-oreochromis-niloticus
#2
Christian Larbi Ayisi, Jinliang Zhao, Jun-Wei Wu
This study was conducted to investigate the effects of replacing dietary fish oil (FO) with palm oil (PO) in juvenile Nile tilapia, Oreochromis niloticus (9.34± 0.02g initial weight) with emphasis on growth performance, digestive enzyme activities as well as serum biochemical parameters. Also, lysozyme activity (LYZ), respiratory burst (RB), superoxide dismutase (SOD), catalase (CAT) and resistance to Streptococcus iniae were investigated. Fish were stocked in 15 rectangular fiber glass tanks (150× 60× 40 cm) at 40 fish per tank with water maintained at 210 litres...
2018: PloS One
https://www.readbyqxmd.com/read/29692782/nod-like-receptor-protein-3-inflammasome-dependent-il-1%C3%AE-accelerated-cona-induced-hepatitis
#3
Jingyun Luan, Xuyao Zhang, Shaofei Wang, Yubin Li, Jiajun Fan, Wei Chen, Wenjing Zai, Sijia Wang, Yichen Wang, Mingkuan Chen, Guangxun Meng, Dianwen Ju
Autoimmune hepatitis (AIH) is a progressive inflammatory disorders of unknown etiology, characterized by immune-mediated destruction of hepatocytes and massive production of cytokines. Interleukin-1β is a pleiotropic proinflammatory cytokine and well known to be critical in a variety of autoimmune diseases. However, the role of interleukin-1β (IL-1β) in AIH is still indistinct. Here, we first investigated the significance of NOD-like receptor protein 3 (NLRP3) inflammasome-dependent IL-1β in the pathogenesis of AIH with a murine model of immune-mediated hepatitis induced by Concanavalin A (ConA)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29692709/lack-of-pannexin-1-alters-synaptic-glun2-subunit-composition-and-spatial-reversal-learning-in-mice
#4
Ivana Gajardo, Claudia S Salazar, Daniela Lopez-Espíndola, Carolina Estay, Carolina Flores-Muñoz, Claudio Elgueta, Arlek M Gonzalez-Jamett, Agustín D Martínez, Pablo Muñoz, Álvaro O Ardiles
Long-term potentiation (LTP) and long-term depression (LTD) are two forms of synaptic plasticity that have been considered as the cellular substrate of memory formation. Although LTP has received considerable more attention, recent evidences indicate that LTD plays also important roles in the acquisition and storage of novel information in the brain. Pannexin 1 (Panx1) is a membrane protein that forms non-selective channels which have been shown to modulate the induction of hippocampal synaptic plasticity. Animals lacking Panx1 or blockade of Pannexin 1 channels precludes the induction of LTD and facilitates LTP...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29692549/a-novel-trichoderma-fusant-for-enhancing-nutritional-value-and-defence-activity-in-chickpea
#5
Aradhana Mishra, Chandra Shekhar Nautiyal
In recent years, due to the rise in food consumption, much of the attention has been focused to increase the yield of the agricultural crops which resulted in compromised nutritional quality. Efforts have to be undertaken to enhance the nutritional attributes of legumes, cereals and staple food crops by increasing amino acids and mineral content. In the present study, we evaluated a protoplast fusant ( H. lixii MTCC 5659) for its ability to enhance nutritional value and defence activity in chickpea. Essential amino acids; methionine (9...
May 2018: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
https://www.readbyqxmd.com/read/29690706/-the-analysis-of-clinical-characteristics-and-disease-activity-in-ankylosing-spondylitis-patients-with-hyperuircemia
#6
X J Zhang, X M Cui, R Y Chen, H T Sun, J J Zhou, L D Jiang
Objective: to investigate the clinical characteristics and disease activity in ankylosing spondylitis (AS) patients with hyperuricemia. Method: Laboratory tests, magnetic resonance imaging, disease activity and functional index of AS patients from Fudan University Zhongshan Hospital were collected. T test, square test were applied to investigate the difference between AS patients with hyperuricemia and AS patients with normal serum uric acid in clinical characteristics and disease activity in AS patients. Result: Among all the AS patients, 23...
April 3, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29688900/noninvasive-tracking-of-anesthesia-neurotoxicity-in-the-developing-rodent-brain
#7
Rany Makaryus, Hedok Lee, John Robinson, Grigori Enikolopov, Helene Benveniste
BACKGROUND: Potential deleterious effect of multiple anesthesia exposures on the developing brain remains a clinical concern. We hypothesized that multiple neonatal anesthesia exposures are more detrimental to brain maturation than an equivalent single exposure, with more pronounced long-term behavioral consequences. We designed a translational approach using proton magnetic resonance spectroscopy in rodents, noninvasively tracking the neuronal marker N-acetyl-aspartate, in addition to tracking behavioral outcomes...
April 24, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29688874/a-putative-electrophysiological-biomarker-of-auditory-sensory-memory-encoding-is-sensitive-to-pharmacological-alterations-of-excitatory-inhibitory-balance-in-male-macaque-monkeys
#8
William B Holliday, Kate Gurnsey, Robert A Sweet, Tobias Teichert
BACKGROUND: The amplitude of the auditory evoked N1 component that can be derived from noninvasive electroencephalographic recordings increases as a function of time between subsequent tones. N1 amplitudes in individuals with schizophrenia saturate at a lower asymptote, thus giving rise to a reduced dynamic range. Reduced N1 dynamic range is a putative electrophysiological biomarker of altered sensory memory function in individuals with the disease. To date, it is not clear what determines N1 dynamic range and what causes reduced N1 dynamic range in individuals with schizophrenia...
May 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29687142/monitoring-the-impact-of-an-aspartic-protease-mpapr1-on-grape-proteins-and-wine-properties
#9
Louwrens Wiid Theron, Marina Bely, Benoit Divol
The perception of haze in wine is brought about when pathogenesis-related proteins become unstable and aggregate, subsequently resulting in crosslinking until it develops into light-dispersing particles. Elimination of these proteins is usually achieved via bentonite fining, which, although effective, suffers from several drawbacks. The utilization of proteases has been proposed as an ideal alternative. In a previous study, an aspartic protease (MpAPr1) from the yeast Metschnikowia pulcherrima was purified and shown to be partially active against grape proteins in synthetic medium...
April 23, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29687092/circulating-spexin-levels-negatively-correlate-with-age-bmi-fasting-glucose-and-triglycerides-in-healthy-adult-women
#10
Cheng-Yuan Lin, Tao Huang, Ling Zhao, Linda L D Zhong, Wai Ching Lam, Bao-Min Fan, Zhao-Xiang Bian
Context: Spexin is a newly identified neuropeptide that is involved in satiety control, glucose, and lipids metabolism. It has also been related to human diseases, such as obesity and type 2 diabetes. However, whether spexin changes with age or not is still unclear. Objective: The aim of this study is to investigate the relationship between circulating spexin levels and age and to study their interaction effects on body mass index (BMI), fasting glucose, and -lipids...
May 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29686945/more-massive-but-potentially-less-healthy-black-vultures-feeding-in-rubbish-dumps-differed-in-clinical-and-biochemical-parameters-with-wild-feeding-birds
#11
Pablo Ignacio Plaza, Sergio Agustin Lambertucci
Background: Organic waste is one of the most important anthropogenic food subsidies used by different species. However, there is little information about the health impact that rubbish dumps produce on species foraging in these sites. Methods: We studied the effect that rubbish dumps produce on the health of a scavenging bird from the Americas, the black vulture ( Coragyps atratus ). We sampled and studied clinical and biochemical parameters in 94 adult black vultures from two different sites in North Western Patagonia, a rubbish dump and the wild steppe...
2018: PeerJ
https://www.readbyqxmd.com/read/29686513/potential-role-of-cyanidin-3-glucoside-c3g-in-diabetic-cardiomyopathy-in-diabetic-rats-an-in-vivo-approach
#12
Weizhen Li, Songwen Chen, Genqing Zhou, Hongli Li, Lan Zhong, Shaowen Liu
The present study aimed to evaluate the importance of cyanidin 3-glucoside (C3G) of diabetic cardiomyopathy in diabetic rats. The rats were induced with diabetic using streptozotocin and total triglyceride (TG) and total cholesterol (TC) were determined. The range of myocardial enzymes such as aspartate aminotransferase (AST), creatine kinase (CK) and lactate dehydrogenase (LD) were also estimated, further, the Immuno histochemical analysis and western blot investigation were determined for the actual activity of C3G...
March 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29686469/evaluation-of-safety-for-hepatectomy-in-a-novel-mouse-model-with-nonalcoholic-steatohepatitis
#13
Yusuke Ozawa, Takafumi Tamura, Yohei Owada, Yoshio Shimizu, Akira Kemmochi, Katsuji Hisakura, Takashi Matsuzaka, Hitoshi Shimano, Hiroko Isoda, Nobuhiro Ohkohchi
AIM: To investigate whether the liver resection volume in a newly developed nonalcoholic steatohepatitis (NASH) model influences surgical outcome. METHODS: For establishment of a NASH model, mice were fed a high-fat diet for 4 wk, administered CCl4 for the last 2 wk, and administered T0901317 for the last 5 d. We divided these mice into two groups: A 30% partial hepatectomy (PH) of NASH liver group and a 70% PH of NASH liver group. In addition, a 70% PH of normal liver group served as the control...
April 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29685517/degradation-rate-affords-a-dynamic-cue-to-regulate-stem-cells-beyond-varied-matrix-stiffness
#14
Yuanmeng Peng, Qiong-Jie Liu, Tianlei He, Kai Ye, Xiang Yao, Jiandong Ding
While various static cues such as matrix stiffness have been known to regulate stem cell differentiation, it is unclear whether or not dynamic cues such as degradation rate along with the change of material chemistry can influence cell behaviors beyond simple integration of static cues such as decreased matrix stiffness. The present research is aimed at examining effects of degradation rates on adhesion and differentiation of mesenchymal stem cells (MSCs) in vitro on well-defined synthetic hydrogel surfaces...
April 12, 2018: Biomaterials
https://www.readbyqxmd.com/read/29685094/effects-of-alcoholic-beverage-treatment-on-spatial-learning-and-fear-memory-in-mice
#15
Narumi Hashikawa-Hobara, Shuta Mishima, Shotaro Nagase, Keishi Morita, Ami Otsuka, Naoya Hashikawa
Although chronic ethanol treatment is known to impair learning and memory, humans commonly consume a range of alcoholic beverages. However, the specific effects of some alcoholic beverages on behavioral performance are largely unknown. The present study compared the effects of a range of alcoholic beverages (plain ethanol solution, red wine, sake and whiskey; with a matched alcohol concentration of 10%) on learning and memory. 6-week-old C57BL6J mice were orally administered alcohol for 7 weeks. The results revealed that red wine treatment exhibited a trend toward improvement of spatial memory and advanced extinction of fear memory...
April 24, 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29685011/glucocorticoids-in-combination-with-ursodesoxycholic-acid-in-the-treatment-of-autoimmune-hepatitis
#16
W Y Li, X S Yang, Y C Wang
Autoimmune hepatitis (AH) is usually manifested as chronic hepatitis in clinics; it may evolve to liver cirrhosis, hepatic failure, and even death if treatment is delayed. To investigate the clinical efficacy of glucocorticoids in combination with ursodesoxycholic acid in the treatment of glucocorticoids in combination with ursodesoxycholic acid, one hundred and twenty patients with AH who were admitted to the hospital from February 2014 and February 2016 were selected and randomly divided into an observation group and a control group using random number table...
March 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29684600/effect-of-high-dietary-starch-levels-on-growth-hepatic-glucose-metabolism-oxidative-status-and-immune-response-of-juvenile-largemouth-bass-micropterus-salmoides
#17
Shi-Mei Lin, Chao-Ming Shi, Ming-Ming Mu, Yong-Jun Chen, Li Luo
An experimental trial was conducted to investigate the effects of high dietary starch levels on growth, hepatic glucose metabolism enzyme, antioxidant capacity and immune responses of largemouth bass, Micropterus salmoides. Fish (initial body weight: 16.9 ± 0.24 g) were fed three isonitrogenous and isoenergetic semi-purified diets containing 5%, 10% and 20% wheat starch, respectively. The results indicated that fish fed 5% and 10% starch diets showed significantly better weight gain, specific growth rate (SGR), protein efficiency ratio (PER) and feed conversion ratio (FCR) compared with that fed 20% starch diet...
April 20, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29684464/tracking-single-membrane-targets-of-human-autoantibodies-using-single-nanoparticle-imaging
#18
Julie Jézéquel, Julien P Dupuis, François Maingret, Laurent Groc
BACKGROUND: Over the past decade, an increasing number of neurological and neuropsychiatric diseases have been associated with the expression of autoantibodies directed against neuronal targets, including neurotransmitter receptors. Although cell-based assays are routinely used in clinics to detect the presence of immunoglobulins, such tests often provide heterogeneous outcomes due to their limited sensitivity, especially at low titers. Thus, there is an urging need for new methods allowing the detection of autoantibodies in seropositive patients that cannot always be clinically distinguished from seronegative ones...
April 20, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29683980/evaluation-of-serum-procollagen-c-proteinase-enhancer-1-level-as-a-fibrosis-marker-in-patients-with-chronic-hepatitis-b
#19
Onur Gokce, Seren Ozenirler, Aysegul Atak Yucel, Nihan Oruklu, Guldal Yilmaz Esendagli, Sevilay Karahan
AIM: Although liver biopsy has long been considered the gold standard for staging fibrosis, because of the disadvantages and risks of biopsy, several noninvasive processes such as serum biomarkers have been introduced for the assessment of liver fibrosis. The aim of this study was to assess the diagnostic value of serum procollagen C-proteinase enhancer 1 (PCPE-1) as a noninvasive fibrosis marker in treatment-naive chronic hepatitis B patients. PATIENTS AND METHODS: This study included 126 patients with biopsy-proven hepatitis B and 50 healthy controls...
April 20, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29683979/lifestyle-interventions-for-patients-with-nonalcoholic-fatty-liver-disease-a-network-meta-analysis
#20
Tian-Tian Zou, Chao Zhang, Yi-Fan Zhou, Yi-Jing Han, Jiao-Jiao Xiong, Xi-Xi Wu, Yong-Ping Chen, Ming-Hua Zheng
Lifestyle interventions remain the first-line therapy for nonalcoholic fatty liver disease (NAFLD). This study aims to evaluate the individual impact of exercise and/or dietary interventions on the level of alanine aminotransferase (ALT), aspartate aminotransferase (AST), homeostasis model of assessment for insulin resistance index (HOMA-IR), and BMI. Randomized-controlled trials from patients diagnosed with NAFLD were included in the meta-analysis if they reported the associations between changes in ALT, AST, HOMA-IR, or BMI and types of lifestyle interventions...
April 20, 2018: European Journal of Gastroenterology & Hepatology
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