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https://www.readbyqxmd.com/read/28241671/the-effect-of-copper-and-selenium-nanocarboxylates-on-biomass-accumulation-and-photosynthetic-energy-transduction-efficiency-of-the-green-algae-chlorella-vulgaris
#1
Natalia F Mykhaylenko, Elena K Zolotareva
Nanoaquachelates, the nanoparticles with the molecules of water and/or carboxylic acids as ligands, are used in many fields of biotechnology. Ultra-pure nanocarboxylates of microelements are the materials of spatial perspective. In the present work, the effects of copper and selenium nanoaquachelates carboxylated with citric acid on biomass accumulation of the green algae Chlorella vulgaris were examined. Besides, the efficiency of the reactions of the light stage of photosynthesis was estimated by measuring chlorophyll a fluorescence...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28241438/lycium-barbarum-l-polysaccharide-lbp-reduces-glucose-uptake-via-down-regulation-of-sglt-1-in-caco2-cell
#2
Huizhen Cai, Xiaohui Yang, Qian Cai, Binbin Ren, Hongyan Qiu, Zhiqing Yao
Lycium barbarum L. polysaccharide (LBP) is prepared from Lycium barbarum L. (L. barbarum), which is a traditional Chinese medicine. LPB has been shown to have hypoglycemic effects. In order to gain some mechanistic insights on the hypoglycemic effects of LBP, we investigated the uptake of LBP and its effect on glucose absorption in the human intestinal epithelial cell line Caco2 cell. The uptake of LBP through Caco2 cell monolayer was time-dependent and was inhibited by phloridzin, a competitive inhibitor of SGLT-1...
February 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28241378/an-experimental-test-of-fitness-variation-across-a-hydrologic-gradient-predicts-willow-and-poplar-species-distributions
#3
Xiaojing Wei, Jessica A Savage, Charlotte E Riggs, Jeannine Cavender-Bares
Environmental filtering is an important community assembly process influencing species distributions. Contrasting species abundance patterns along environmental gradients are commonly used to provide evidence for environmental filtering. However, the same abundance patterns may result from alternative or concurrent assembly processes. Experimental tests are an important means to decipher whether species fitness varies with environment, in the absence of dispersal constraints and biotic interactions, and to draw conclusions about the importance of environmental filtering in community assembly...
February 27, 2017: Ecology
https://www.readbyqxmd.com/read/28241117/supported-microwires-for-electroanalysis-sensitive-amperometric-detection-of-reduced-glutathione
#4
Kamonwad Ngamchuea, Chuhong Lin, Christopher Batchelor-McAuley, Richard G Compton
A carbon microfiber (7 μm diameter) is employed herein as an electroanalytical sensor. The fabricated sensor is cheap, disposable and requires only 150 μL of samples. The carbon fiber is surface-mounted onto an inert surface to overcome the problems of the fragility of the microwire and the possible interference of convective force due to the non-rigid nature of the wires, as well as to improve the reproducibility in length and the amperometric responses. As the cylindrical electrode is supported on a surface, the diffusion of redox-active species to the electrode is partially blocked by the substrate...
February 27, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28241068/liver-x-receptor-agonist-treatment-significantly-affects-phenotype-and-transcriptome-of-apoe3-and-apoe4-abca1-haplo-deficient-mice
#5
Alexis Y Carter, Florent Letronne, Nicholas F Fitz, Anais Mounier, Cody M Wolfe, Kyong Nyon Nam, Valerie L Reeves, Hafsa Kamboh, Iliya Lefterov, Radosveta Koldamova
ATP-binding cassette transporter A1 (ABCA1) controls cholesterol and phospholipid efflux to lipid-poor apolipoprotein E (APOE) and is transcriptionally controlled by Liver X receptors (LXRs) and Retinoic X Receptors (RXRs). In APP transgenic mice, lack of Abca1 increased Aβ deposition and cognitive deficits. Abca1 haplo-deficiency in mice expressing human APOE isoforms, increased level of Aβ oligomers and worsened memory deficits, preferentially in APOE4 mice. In contrast upregulation of Abca1 by LXR/RXR agonists significantly ameliorated pathological phenotype of those mice...
2017: PloS One
https://www.readbyqxmd.com/read/28241065/repeated-dexamphetamine-treatment-alters-the-dopaminergic-system-and-increases-the-phmri-response-to-methylphenidate
#6
Anouk Schrantee, Jordi L Tremoleda, Marzena Wylezinska-Arridge, Valentine Bouet, Peter Hesseling, Gideon F Meerhoff, Kora M de Bruin, Jan Koeleman, Thomas Freret, Michel Boulouard, Emilie Desfosses, Laurent Galineau, Alessandro Gozzi, François Dauphin, Willy Gsell, Jan Booij, Paul J Lucassen, Liesbeth Reneman
Dexamphetamine (AMPH) is a psychostimulant drug that is used both recreationally and as medication for attention deficit hyperactivity disorder. Preclinical studies have demonstrated that repeated exposure to AMPH can induce damage to nerve terminals of dopamine (DA) neurons. We here assessed the underlying neurobiological changes in the DA system following repeated AMPH exposure and pre-treated rats with AMPH or saline (4 times 5 mg/kg s.c., 2 hours apart), followed by a 1-week washout period. We then used pharmacological MRI (phMRI) with a methylphenidate (MPH) challenge, as a sensitive and non-invasive in-vivo measure of DAergic function...
2017: PloS One
https://www.readbyqxmd.com/read/28241060/nematode-neuropeptides-as-transgenic-nematicides
#7
Neil D Warnock, Leonie Wilson, Cheryl Patten, Colin C Fleming, Aaron G Maule, Johnathan J Dalzell
Plant parasitic nematodes (PPNs) seriously threaten global food security. Conventionally an integrated approach to PPN management has relied heavily on carbamate, organophosphate and fumigant nematicides which are now being withdrawn over environmental health and safety concerns. This progressive withdrawal has left a significant shortcoming in our ability to manage these economically important parasites, and highlights the need for novel and robust control methods. Nematodes can assimilate exogenous peptides through retrograde transport along the chemosensory amphid neurons...
February 27, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28241045/effects-upon-metabolic-pathways-and-energy-production-by-sb-iii-and-as-iii-sb-iii-oxidase-gene-aioa-in-agrobacterium-tumefaciens-gw4
#8
Jingxin Li, Birong Yang, Manman Shi, Kai Yuan, Wei Guo, Mingshun Li, Gejiao Wang
Agrobacterium tumefaciens GW4 is a heterotrophic arsenite [As(III)]/antimonite [Sb(III)]-oxidizing strain. The As(III) oxidase AioAB is responsible for As(III) oxidation in the periplasm and it is also involved in Sb(III) oxidation in Agrobacterium tumefaciens 5A. In addition, Sb(III) oxidase AnoA and cellular H2O2 are also responsible for Sb(III) oxidation in strain GW4. However, the deletion of aioA increased the Sb(III) oxidation efficiency in strain GW4. In the present study, we found that the cell mobility to Sb(III), ATP and NADH contents and heat release were also increased by Sb(III) and more significantly in the aioA mutant...
2017: PloS One
https://www.readbyqxmd.com/read/28240953/cardiorespiratory-function-in-thoroughbreds-during-locomotion-on-a-treadmill-at-an-incline-or-decline
#9
Hajime Ohmura, Kazutaka Mukai, Toshiyuki Takahashi, Hiroko Aida, James H Jones
OBJECTIVE To determine cardiorespiratory responses of Thoroughbreds to uphill and downhill locomotion on a treadmill at identical gradients. ANIMALS 5 highly trained Thoroughbred geldings. PROCEDURES Thoroughbreds were exercised for 2-minute intervals on a treadmill at 1.7, 3.5, 6.0, 8.0, and 10.0 m/s at a 4% incline, 0% incline (horizontal plane), and 4% decline in random order on different days. Stride frequency, stride length, and cardiopulmonary and O2-transport variables were measured and analyzed by means of repeated-measures ANOVA and Holm-Šidák pairwise comparisons...
March 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28240911/comprehensive-enhancement-of-nanostructured-lithium-ion-battery-cathode-materials-via-conformal-graphene-dispersion
#10
Kan-Sheng Chen, Rui Xu, Norman S Luu, Ethan B Secor, Koichi Hamamoto, Qianqian Li, Soo Kim, Vinod K Sangwan, Itamar Balla, Linda M Guiney, Jung-Woo T Seo, Xiankai Yu, Weiwei Liu, Jinsong Wu, Chris Wolverton, Vinayak P Dravid, Scott A Barnett, Jun Lu, Khalil Amine, Mark C Hersam
Efficient energy storage systems based on lithium-ion batteries represent a critical technology across many sectors including consumer electronics, electrified transportation, and a smart grid accommodating intermittent renewable energy sources. Nanostructured electrode materials present compelling opportunities for high-performance lithium-ion batteries, but inherent problems related to the high surface area to volume ratios at the nanometer-scale have impeded their adoption for commercial applications. Here, we demonstrate a materials and processing platform that realizes high-performance nanostructured lithium manganese oxide (nano-LMO) spinel cathodes with conformal graphene coatings as a conductive additive...
February 27, 2017: Nano Letters
https://www.readbyqxmd.com/read/28240895/single-crystal-pentacene-valence-band-dispersion-and-its-temperature-dependence
#11
Yasuo Nakayama, Yuta Mizuno, Masataka Hikasa, Masayuki Yamamoto, Masaharu Matsunami, Shinichiro Ideta, Kiyohisa Tanaka, Hisao Ishii, Nobuo Ueno
The electronic structures of the highest occupied molecular orbital (HOMO) or the HOMO-derived valence bands dominate the transport nature of positive charge carriers (holes) in organic semiconductors. In the present study, the valence band structures of single crystal pentacene and the temperature dependence of their energy-momentum dispersion relations are successfully demonstrated using angle-resolved ultraviolet photoelectron spectroscopy (ARUPS). For the shallowest valence band, the intermolecular transfer integral and effective mass of the holes are evaluated as 43...
February 27, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28240893/how-intrinsic-dynamics-mediate-the-allosteric-mechanism-in-the-abc-transporter-nucleotide-binding-domain-dimer
#12
Peter M Jones, Anthony M George
A protein's architecture facilitates specific motions - intrinsic dynamic modes - that are employed to effect function. Here we used molecular dynamics (MD) simulations to investigate the dynamics of the MJ0796 ABC transporter nucleotide-binding domain (NBD). ABC transporter NBDs form a rotationally symmetric dimer whereby two equivalent active sites are formed at their interface; in complex with a dimer of transmembrane domains they hydrolyse ATP to energise translocation of substrates across cellular membranes...
February 27, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28240870/a-multifunctional-envelope-type-sirna-delivery-nanoparticle-platform-for-prostate-cancer-therapy
#13
Xiaoding Xu, Jun Wu, Yanlan Liu, Phei Er Saw, Wei Tao, Mikyung Yu, Harshal R Zope, Michelle Si, Amanda Victorious, Jonathan Rasmussen, Dana Ayyash, Omid C Farokhzad, Jinjun Shi
With the capability of specific silencing of target gene expression, RNA interference (RNAi) technology is emerging as a promising therapeutic modality for the treatment of cancer and other diseases. One key challenge for the clinical applications of RNAi is the safe and effective delivery of RNAi agents such as small interfering RNA (siRNA) to a particular non-liver diseased tissue (e.g., tumor) and cell type with sufficient cytosolic transport. In this work, we proposed a multifunctional envelope-type nanoparticle (NP) platform for prostate cancer (PCa)-specific in vivo siRNA delivery...
February 27, 2017: ACS Nano
https://www.readbyqxmd.com/read/28240806/suppression-of-phonon-transport-in-molecular-christmas-trees
#14
Colin John Lambert, Marjan Famili, Iain Grace, Hatef Sadeghi
Minimising the phonon thermal conductance of self-assembled molecular films, whilst preserving their electrical properties, is highly desirable, both for thermal management at the nanoscale and for the design of high-efficiency thermoelectric materials. Here we highlight a new strategy for minimising the phonon thermal conductance of Christmas-tree-like molecules composed of a long trunk, along which phonons can propagate, attached to pendant molecular branches. We demonstrate that phonon transport along the trunk is suppressed by Fano resonances associated with internal vibrational modes of the branches and that thermal conductance is suppressed most-effectively in molecules with pendant branches of different lengths...
February 27, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28240790/recently-differentiated-epimastigotes-from-trypanosoma-cruzi-are-infective-to-the-mammalian-host
#15
Rafael Luis Kessler, Víctor Tulio Contreras, Newmar Pinto Marliére, Alessandra Aparecida Guarneri, Luz Helena Villamizar Silva, Giovanny Augusto Camacho Antevere Mazzarotto, Michel Batista, Vanete Thomaz Soccol, Marco Aurelio Krieger, Christian Macagnan Probst
Trypanosoma cruzi, the etiologic agent of Chagas disease, has a complex life cycle in which four distinct developmental forms alternate between the insect vector and the mammalian host. It is assumed that replicating epimastigotes present in the insect gut are not infective to mammalian host, a paradigm corroborated by the widely acknowledged fact that only this stage is susceptible to the complement system. In the present work, we establish a T. cruzi in vitro and in vivo epimastigogenesis model to analyze the biological aspects of recently differentiated epimastigotes (rdEpi)...
February 27, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28240751/rescaling-metal-molybdate-nanostructures-with-biopolymer-for-energy-storage-having-high-capacitance-with-robust-cycle-stability
#16
Manickam Minakshi, Maryam J Barmi, Robert T Jones
Hybrid capacitors can replace or complement batteries, while storing energy through ion adsorption and fast surface redox reactions. There is a growing demand in developing nanostructured materials as electrodes for hybrid systems that can enhance the specific capacitance by ion desolvation in the nanopores. Here, we demonstrate that rescaling the pore diameter with the aid of biopolymer at an optimal level during the synthesis of metal molybdate leads to high capacitance 124 F g(-1) giving robust capacitance retention of 80% over 2000 cycles for a constructed device (activated carbon vs...
February 27, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28240653/paraspinal-muscle-passive-stiffness-remodels-in-direct-response-to-spine-stiffness-a-study-using-the-ent1-deficient-mouse
#17
Kelsey Y Gsell, Derek P Zwambag, Dale E Fournier, Cheryle A Séguin, Stephen H M Brown
STUDY DESIGN: Basic science study of the relationship between the structural properties of the spine and its surrounding musculature. OBJECTIVE: To determine if an increase in spine stiffness causes an inverse compensatory change in the passive stiffness of the adjacent paraspinal muscles. SUMMARY OF BACKGROUND DATA: Intervertebral disc degeneration causes an increase in multifidus passive stiffness; this was hypothesized to compensate for a decrease in spine stiffness associated with disc degeneration...
February 24, 2017: Spine
https://www.readbyqxmd.com/read/28240643/heart-allograft-preservation-an-arduous-journey-from-the-donor-to-the-recipient
#18
Michiel Erasmus, Arne Neyrink, Mario Sabatino, Luciano Potena
PURPOSE OF REVIEW: The discrepancy between needs and availability of organs for heart transplantation may be partially reduced by improving the utilization of organs currently deemed unsuitable. Strategies to achieve this goal need optimization of the entire process of organ procurement, transportation, and functional recovery after transplant. RECENT FINDINGS: In the latest years, several studies reported improvements in organ utilization after appropriate donor management, and management of heart transportation is approaching a new era...
February 24, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28240547/size-tuning-of-wse2-flakes-for-high-efficiency-inverted-organic-solar-cells
#19
George Kakavelakis, Antonio Esau Del Rio Castillo, Vittorio Pellegrini, Alberto Ansaldo, Pavlos E Tzourmpakis, Rosaria Brescia, Mirko Prato, Emmanuel Stratakis, Emmanuel Kymakis, Francesco Bonaccorso
The development of large-scale production methods of two-dimensional (2D) crystals, with on-demand control of the area and thickness, is mandatory to fulfill the potential applications of such nanomaterials for photovoltaics. Inverted bulk heterojunction (BHJ) organic solar cell (OSC), that exploits a polymer-fullerene binary blend as the active material, is one potentially important application area for 2D crystals. A large ongoing effort is indeed currently devoted to the introduction of 2D crystals in the binary blend to improve the charge transport properties...
February 27, 2017: ACS Nano
https://www.readbyqxmd.com/read/28240401/isomer-pure-bis-pcbm-assisted-crystal-engineering-of-perovskite-solar-cells-showing-excellent-efficiency-and-stability
#20
Fei Zhang, Wenda Shi, Jingshan Luo, Norman Pellet, Chenyi Yi, Xiong Li, Xiaoming Zhao, T John S Dennis, Xianggao Li, Shirong Wang, Yin Xiao, Shaik Mohammed Zakeeruddin, Dongqin Bi, Michael Grätzel
A fullerene derivative (α-bis-PCBM) is purified from an as-produced bis-phenyl-C61 -butyric acid methyl ester (bis-[60]PCBM) isomer mixture by preparative peak-recycling, high-performance liquid chromatography, and is employed as a templating agent for solution processing of metal halide perovskite films via an antisolvent method. The resulting α-bis-PCBM-containing perovskite solar cells achieve better stability, efficiency, and reproducibility when compared with analogous cells containing PCBM. α-bis-PCBM fills the vacancies and grain boundaries of the perovskite film, enhancing the crystallization of perovskites and addressing the issue of slow electron extraction...
February 27, 2017: Advanced Materials
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