Feng Yao, Yingjie Zhao, Qiuxia Yu, Weirong Hu, Yi Lin, Yong Chen, Lin Li, Cheng Sun, Shufang Li, Ke Wang, Min Yang, Renpeng Zhou, Wei Hu
The development of rheumatoid arthritis (RA) is closely related to the excessive activation of fibroblast-like synoviocytes (FLSs), which are regulated by a variety of endogenous proinflammatory molecules. Extracellular cold-inducible RNA-binding protein (CIRP), as a novel endogenous proinflammatory molecule, plays an important role in inflammatory diseases. More importantly, the synovial concentration of CIRP in patients with RA was significantly higher than that in patients with osteoarthritis (OA). Thus, this study aimed to investigate the role of extracellular CIRP in the abnormal activation of RA-FLSs and its related mechanisms...
January 12, 2024: International Immunopharmacology