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Cold inducible rna binding protein

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https://www.readbyqxmd.com/read/28419375/transcriptional-profiling-of-cholinergic-neurons-from-basal-forebrain-identifies-changes-in-expression-of-genes-between-sleep-and-wake-mrna-profiling-in-basal-forebrain-with-sleep-sleep-deprivation
#1
Elena V Nikonova, Jason DA Gilliland, Keith Q Tanis, Alexei A Podtelezhnikov, Alison M Rigby, Raymond J Galante, Eva M Finney, David J Stone, John J Renger, Allan I Pack, Christopher J Winrow
Study objective: To assess differences in gene expression in cholinergic basal forebrain cells between sleeping and sleep deprived mice sacrificed at the same time of day. Methods: Tg(ChAT-eGFP)86Gsat mice expressing eGFP under control of the choline acetyltransferase (Chat) promoter were utilized to guide laser capture of cholinergic cells in basal forebrain. mRNA expression levels in these cells were profiled using microarrays. Gene expression in eGFP(+) neurons was compared (1) to that in eGFP(-) neurons and to adjacent white matter, (2) between 7:00 am (lights on) and 7:00 pm (lights off), (3) between sleep deprived and sleeping animals at 0, 3, 6, 9 hrs from lights on...
April 13, 2017: Sleep
https://www.readbyqxmd.com/read/28373441/expression-of-rna-binding-motif-protein-3-rbm3-and-cold-inducible-rna-binding-protein-cirp-is-associated-with-improved-clinical-outcome-in-patients-with-colon-cancer
#2
Ho Hee Jang, Hae Na Lee, So-Young Kim, Suntaek Hong, Won-Suk Lee
BACKGROUND: Recent studies have shown a potential role of RNA-binding proteins (RBPs) in a variety of biological pathways, including cancer progression, whilst their expression in various tumor types may be associated with patient prognosis. However, the role of the RBP family members has not been explored in colon cancer and their possible use as prognostic biomarkers is largely unknown. MATERIALS AND METHODS: To determine the prognostic role of three RBP genes: insulin-like growth factor-binding protein 2 (IGFBP2), RNA-binding motif protein 3 (RBM3), and cold-inducible RNA-binding protein (CIRP) in colon cancer...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28355355/cirbp-protects-h9c2-cells-against-myocardial-ischemia-through-inhibition-of-nf-%C3%AE%C2%BAb-pathway
#3
T Y Long, R Jing, F Kuang, L Huang, Z X Qian, T L Yang
Myocardial ischemia is a major cause of death and remains a disease with extremely deficient clinical therapies and a major problem worldwide. Cold inducible RNA-binding protein (CIRBP) is reported to be involved in multiple pathological processes, including myocardial ischemia. However, the molecular mechanisms of myocardial ischemia remain elusive. Here, we first overexpressed CIRBP by transfection of pc-CIRBP (pcDNA3.1 containing coding sequenced for CIRBP) and silenced CIRBP by transfection of small interfering RNA targeting CIRBP (siCIRBP)...
March 23, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28296279/an-immunohistochemical-approach-to-identify-the-sex-of-young-marine-turtles
#4
Boris M Tezak, Kathleen Guthrie, Jeanette Wyneken
Marine turtles exhibit temperature-dependent sex determination (TSD). During critical periods of embryonic development, the nest's thermal environment directs whether an embryo will develop as a male or female. At warmer sand temperatures nests tend to produce female-biased sex ratios. The rapid increase of global temperature highlights the need for a clear assessment of its effects on sea turtle sex ratios. However, estimating hatchling sex ratios at rookeries remains imprecise due to the lack of sexual dimorphism in young marine turtles...
March 13, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28267416/posttranscriptional-mechanisms-controlling-diurnal-gene-expression-cycles-by-body-temperature-rhythms
#5
Ivana Gotic, Ueli Schibler
In mammals, body temperature oscillates in a daily fashion around a set point of 36°C-37°C. These fluctuations are controlled by the circadian master clock residing in the brain's suprachiasmatic nucleus and, despite their small amplitudes, contribute to the diurnal expression of genes throughout the organism. By focusing on the mechanisms underlying the temperature-dependent accumulation of the cold-inducible RNA-binding protein CIRBP - a factor involved in the tuning of amplitude and phase in circadian clocks of peripheral tissues - we have recently identified a novel mechanism governing temperature-dependent gene expression...
March 2, 2017: RNA Biology
https://www.readbyqxmd.com/read/28241738/response-of-micrornas-to-cold-treatment-in-the-young-spikes-of-common-wheat
#6
Guoqi Song, Rongzhi Zhang, Shujuan Zhang, Yulian Li, Jie Gao, Xiaodong Han, Mingli Chen, Jiao Wang, Wei Li, Genying Li
BACKGROUND: MicroRNAs (miRNAs) are a class of small non-coding RNAs that play important roles in biotic and abiotic stresses by regulating their target genes. For common wheat, spring frost damage frequently occurs, especially when low temperature coincides with plants at early floral organ differentiation, which may result in significant yield loss. Up to date, the role of miRNAs in wheat response to frost stress is not well understood. RESULTS: We report here the sequencing of small RNA transcriptomes from the young spikes that were treated with cold stress and the comparative analysis with those of the control...
February 28, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28189052/a-novel-zea-mays-ssp-mexicana-l-myc-type-ice-like-transcription-factor-gene-zmmice1-enhances-freezing-tolerance-in-transgenic-arabidopsis-thaliana
#7
Xiang Lu, Lei Yang, Mengyuan Yu, Jianbin Lai, Chao Wang, David McNeil, Meixue Zhou, Chengwei Yang
The annual Zea mays ssp. mexicana L., a member of the teosinte group, is a close wild relative of maize and thus can be effectively used in maize improvement. In this study, an ICE-like gene, ZmmICE1, was isolated from a cDNA library of RNA-Seq from cold-treated seedling tissues of Zea mays ssp. mexicana L. The deduced protein of ZmmICE1 contains a highly conserved basic helix-loop-helix (bHLH) domain and C-terminal region of ICE-like proteins. The ZmmICE1 protein localizes to the nucleus and shows sumoylation when expressed in an Escherichia coli reconstitution system...
February 5, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28174577/a-novel-rna-binding-protein-involves-aba-signaling-by-post-transcriptionally-repressing-abi2
#8
Jianwen Xu, Yihan Chen, Luofeng Qian, Rong Mu, Xi Yuan, Huimin Fang, Xi Huang, Enshun Xu, Hongsheng Zhang, Ji Huang
The Stress Associated RNA-binding protein 1 (SRP1) repressed by ABA, salt and cold encodes a C2C2-type zinc finger protein in Arabidopsis. The knock-out mutation in srp1 reduced the sensitivity of seed to ABA and salt stress during germination and post-germinative growth stages. In contrast, SRP1-overexpressing seedlings were more sensitive to ABA and salt compared to wild type plants. In the presence of ABA, the transcript levels of ABA signaling and germination-related genes including ABI3. ABI5. EM1 and EM6 were less induced in srp1 compared to WT...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28134320/rna-binding-protein-rbm3-prevents-no-induced-apoptosis-in-human-neuroblastoma-cells-by-modulating-p38-signaling-and-mir-143
#9
Hai-Jie Yang, Fei Ju, Xin-Xin Guo, Shuang-Ping Ma, Lei Wang, Bin-Feng Cheng, Rui-Juan Zhuang, Bin-Bin Zhang, Xiang Shi, Zhi-Wei Feng, Mian Wang
Nitric oxide (NO)-induced apoptosis in neurons is an important cause of neurodegenerative disease in humans. The cold-inducible protein RBM3 mediates the protective effects of cooling on apoptosis induced by various insults. However, whether RBM3 protects neural cells from NO-induced apoptosis is unclear. This study aimed to investigate the neuroprotective effect of RBM3 on NO-induced apoptosis in human SH-SY5Y neuroblastoma cells. Firstly, we demonstrated that mild hypothermia (32 °C) induces RBM3 expression and confers a potent neuroprotective effect on NO-induced apoptosis, which was substantially diminished when RBM3 was silenced by siRNA...
January 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28128330/cold-inducible-rna-binding-protein-cirp-causes-sepsis-associated-acute-lung-injury-via-induction-of-endoplasmic-reticulum-stress
#10
Mohammad Moshahid Khan, Weng-Lang Yang, Max Brenner, Alexandra Cerutti Bolognese, Ping Wang
Cold-inducible RNA-binding protein (CIRP), released into the circulation during sepsis, causes lung injury via an as yet unknown mechanism. Since endoplasmic reticulum (ER) stress is associated with acute lung injury (ALI), we hypothesized that CIRP causes ALI via induction of ER stress. To test this hypothesis, we studied the lungs of wild-type (WT) and CIRP knockout (KO) mice at 20 h after induction of sepsis by cecal ligation and puncture (CLP). WT mice had significantly more severe ALI than CIRP KO mice...
January 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28118608/rna-binding-motif-protein-3-a-potential-biomarker-in-cancer-and-therapeutic-target-in-neuroprotection
#11
REVIEW
Ren-Bin Zhou, Xiao-Li Lu, Chen-Yan Zhang, Da-Chuan Yin
RNA binding motif 3 (RBM3) is a highly conserved cold-induced RNA binding protein that is transcriptionally up-regulated in response to harsh stresses. Featured as RNA binding protein, RBM3 is involved in mRNA biogenesis as well as stimulating protein synthesis, promoting proliferation and exerting anti-apoptotic functions. Nowadays, accumulating immunohistochemically studies have suggested RBM3 function as a proto-oncogene that is associated with tumor progression and metastasis in various cancers. Moreover, emerging evidences have also indicated that RBM3 is equally effective in neuroprotection...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/27830872/cloning-and-expression-of-cold-inducible-rna-binding-protein-in-domestic-yak-bos-grunniens
#12
K Yang, Q Zhang, Z Wen, Y Pan, S Yu, J He, X Yang, P Liu, Y Cui
Cold-inducible RNA binding protein (CIRP) is over-expressed during cold and many other stresses, and could regulate the adaptation to hypothermia. In the present investigation, the objective was to determine the expression of CIRP in adult yak heart, liver, spleen, lung, kidney, brain, ovary, testis and skin by relative quantitative real time polymerase chain reaction (RT-PCR), Western blot and immunohistochemistry from mRNA and protein levels. The CIRP open reading frame encoding was cloned from the domestic yak brain...
2016: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/27664233/-cold-cuts-added-to-the-circadian-smorgasbord-of-regulatory-mechanisms
#13
Carla B Green
In mammals, rhythms in body temperature help to entrain and synchronize circadian rhythms throughout the organism, and the cold-inducible RNA-binding protein (CIRBP) is one of the mediators of these daily temperature changes. Cirbp mRNA expression is regulated by the daily subtle rhythms in body temperature, and a new study by Gotic and colleagues (pp. 2005-2017) reveals a surprising and novel mechanism that involves temperature-dependent enhancement of splicing efficiency.
September 1, 2016: Genes & Development
https://www.readbyqxmd.com/read/27633015/temperature-regulates-splicing-efficiency-of-the-cold-inducible-rna-binding-protein-gene-cirbp
#14
Ivana Gotic, Saeed Omidi, Fabienne Fleury-Olela, Nacho Molina, Felix Naef, Ueli Schibler
In mammals, body temperature fluctuates diurnally around a mean value of 36°C-37°C. Despite the small differences between minimal and maximal values, body temperature rhythms can drive robust cycles in gene expression in cultured cells and, likely, animals. Here we studied the mechanisms responsible for the temperature-dependent expression of cold-inducible RNA-binding protein (CIRBP). In NIH3T3 fibroblasts exposed to simulated mouse body temperature cycles, Cirbp mRNA oscillates about threefold in abundance, as it does in mouse livers...
September 1, 2016: Genes & Development
https://www.readbyqxmd.com/read/27569563/cold-inducible-rna-binding-protein-activates-splenic-t-cells-during-sepsis-in-a-tlr4-dependent-manner
#15
Alexandra C Bolognese, Archna Sharma, Weng-Lang Yang, Jeffrey Nicastro, Gene F Coppa, Ping Wang
Cold-inducible RNA-binding protein (CIRP) is a novel inflammatory mediator that stimulates the release of proinflammatory cytokines from macrophages in sepsis. Given the immune dysregulation that characterizes sepsis, the effect of CIRP on other immune cells is an area of increasing interest that has not yet been studied. In the present study, we hypothesized that extracellular CIRP promotes activation of T lymphocytes in the spleen during sepsis. We observed that mice subjected to sepsis by cecal ligation and puncture showed significantly higher expression of the early activation markers CD69 and CD25 at 20 h on CD4(+) splenic T cells, and significantly higher CD69 expression on CD8(+) splenic T cells compared with sham-operated controls...
August 29, 2016: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/27556928/cold-shock-proteins-are-expressed-in-the-retina-following-exposure-to-low-temperatures
#16
Ignacio M Larrayoz, Manuel Rey-Funes, Daniela S Contartese, Federico Rolón, Anibal Sarotto, Veronica B Dorfman, Cesar F Loidl, Alfredo Martínez
Hypothermia has been proposed as a therapeutic intervention for some retinal conditions, including ischemic insults. Cold exposure elevates expression of cold-shock proteins (CSP), including RNA-binding motif protein 3 (RBM3) and cold inducible RNA-binding protein (CIRP), but their presence in mammalian retina is so far unknown. Here we show the effects of hypothermia on the expression of these CSPs in retina-derived cell lines and in the retina of newborn and adult rats. Two cell lines of retinal origin, R28 and mRPE, were exposed to 32°C for different time periods and CSP expression was measured by qRT-PCR and Western blotting...
2016: PloS One
https://www.readbyqxmd.com/read/27477308/cold-inducible-rna-binding-protein-mediates-airway-inflammation-and-mucus-hypersecretion-through-a-post-transcriptional-regulatory-mechanism-under-cold-stress
#17
Yang Juan, Wu Haiqiao, Wenyao Xie, Huang Huaping, Han Zhong, Zhou Xiangdong, Victor P Kolosov, Juliy M Perelman
Acute or chronic cold exposure exacerbates chronic inflammatory airway diseases, such as chronic obstructive pulmonary disease (COPD) and asthma. Cold-inducible RNA-binding protein (CIRP) is a cold-shock protein and is induced by various environmental stressors, such as hypothermia and hypoxia. In this study, we showed that CIRP gene and protein levels were significantly increased in patients with COPD and in rats with chronic airway inflammation compared with healthy subjects. Similarly, inflammatory cytokine production and MUC5AC secretion were up-regulated in rats following cigarette smoke inhalation...
September 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27449001/the-5-untranslated-region-of-the-rbp1-mrna-is-required-for-translation-of-its-mrna-under-low-temperatures-in-the-cyanobacterium-synechococcus-elongatus
#18
Rie Hayashi, Chieko Sugita, Mamoru Sugita
The unicellular cyanobacterium Synechococcus elongatus has three RNA-binding protein (Rbp) genes, rbp1, rbp2 and rbp3. The rbp1 gene was upregulated by cold treatment while rbp2 and rbp3 expression decreased remarkably after exposure to cold temperatures. To investigate the mechanism underlying cold-induced rbp1 expression, a series of rbp1-luxAB transcriptional fusion constructs were expressed in S. elongatus PCC 7942 under cold conditions. The results showed that the region from -33 to -3 of the transcription initiation site contains an essential sequence for basal transcription of the rbp1 gene and that the 120-bp region (-34 to -153) does not contain critical cis-elements required for cold-shock induction...
January 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/27423012/cold-inducible-rna-binding-protein-mediates-cold-air-inducible-airway-mucin-production-through-tlr4-nf-%C3%AE%C2%BAb-signaling-pathway
#19
Lingxiu Chen, Danhua Ran, Wenyue Xie, Qing Xu, Xiangdong Zhou
Mucus overproduction is an important feature in patients with chronic inflammatory airway diseases and cold air stimulation has been shown to be associated with the severity of these diseases. However, the regulatory mechanisms that mediate excessive mucin production under cold stress remain elusive. Recently, the cold-inducible RNA-binding protein (CIRP) has been shown to be markedly induced after exposure to cold air. In this study, we sought to explore the expression of CIRP within bronchial biopsy specimens, the effect on mucin5AC (MUC5AC) production in chronic inflammatory airway diseases and the potential signaling pathways involved in cold air stimulation process...
October 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27400471/transcriptome-analysis-of-blood-stasis-syndrome-in-subjects-with-hypertension
#20
Ling He, Meixia Fang, Liguo Chen, Jianhua Zhou, Jing Yuan, Jing Xu, Yan Shan, Qingyun Xu, Tingting Xiong
OBJECTIVE: To screen for mRNAs associated with blood stasis syndrome and to explore the genetic mechanisms of blood stasis syndrome in hypertension. METHODS: This study involved groups of patients with hypertension and blood stasis, including those with Qi deficiency, Qi stagnation, cold retention and heat retention; as well as hypertensive patients without blood stasis and healthy individuals. Human umbilical vein endothelial cells were co-cultured with the sera of these healthy individuals and patients with blood stasis syndrome...
April 2016: Journal of Traditional Chinese Medicine, Chung i Tsa Chih Ying Wen Pan
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