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Cold inducible rna-binding protein

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https://www.readbyqxmd.com/read/29743635/morphoregulatory-functions-of-the-rna-binding-motif-protein-3-in-cell-spreading-polarity-and-migration
#1
J Pilotte, W Kiosses, S W Chan, H P Makarenkova, E Dupont-Versteegden, P W Vanderklish
RNA-binding proteins are emerging as key regulators of transitions in cell morphology. The RNA-binding motif protein 3 (RBM3) is a cold-inducible RNA-binding protein with broadly relevant roles in cellular protection, and putative functions in cancer and development. Several findings suggest that RBM3 has morphoregulatory functions germane to its roles in these contexts. For example, RBM3 helps maintain the morphological integrity of cell protrusions during cell stress and disease. Moreover, it is highly expressed in migrating neurons of the developing brain and in cancer invadopodia, suggesting roles in migration...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29740470/a-glycine-rich-rna-binding-protein-csgr-rbp3-is-involved-in-defense-responses-against-cold-stress-in-harvested-cucumber-cucumis-sativus-l-fruit
#2
Bin Wang, Guang Wang, Fei Shen, Shijiang Zhu
Plant glycine-rich RNA-binding proteins (GR-RBPs) have been shown to play important roles in response to abiotic stresses in actively proliferating organs such as young plants, root tips, and flowers, but their roles in chilling responses of harvested fruit remains largely unknown. Here, we investigated the role of CsGR-RBP3 in the chilling response of cucumber fruit. Pre-storage cold acclimation at 10°C (PsCA) for 3 days significantly enhanced chilling tolerance of cucumber fruit compared with the control fruit that were stored at 5°C...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29463416/irradiation-of-rainbow-trout-at-early-life-stages-results-in-a-proteomic-legacy-in-adult-gills-part-a-proteomic-responses-in-the-irradiated-fish-and-in-non-irradiated-bystander-fish
#3
Richard W Smith, Richard D Moccia, Colin B Seymour, Carmel E Mothersill
Exposure to a single 0.5 Gy X-ray dose of eggs at 48 h after fertilisation (48 h egg), eyed eggs, yolk sac larvae (YSL) and first feeders induces a legacy effect in adult rainbow trout. This includes the transmission of a bystander effect to non-irradiated adult trout which had swam with the irradiated fish. The aim of this study was to investigate this legacy by analysing the gill proteome of these irradiated and bystander fish. Irradiation at all of the early life stages resulted in changes to proteins which play a key role in development but are also known to be anti-tumorigenic and anti-oxidant: upregulation of haemoglobin subunit beta (48 h egg), haemoglobin, serum albumin 1 precursor (eyed eggs), clathrin heavy chain 1 isoform X10 (eyed eggs and first feeders), and actin-related protein 2/3 complex subunit 4 (first feeders), downregulation of pyruvate dehydrogenase, histone 1 (48 h egg), triosephosphate isomerase (TPI), collagen alpha-1(1) chain like proteins (YSL), pyruvate kinase PKM-like protein (YSL and first feeders), ubiquitin-40S ribosomal proteins S27 and eukaryotic translation initiation factor 4 A isoform 1B (first feeders)...
May 2018: Environmental Research
https://www.readbyqxmd.com/read/29434211/a-cold-inducible-rna-binding-protein-cirp-derived-peptide-attenuates-inflammation-and-organ-injury-in-septic-mice
#4
Fangming Zhang, Max Brenner, Weng-Lang Yang, Ping Wang
Cold-inducible RNA-binding protein (CIRP) is a novel sepsis inflammatory mediator and C23 is a putative CIRP competitive inhibitor. Therefore, we hypothesized that C23 can ameliorate sepsis-associated injury to the lungs and kidneys. First, we confirmed that C23 dose-dependently inhibited TNF-α release, IκBα degradation, and NF-κB nuclear translocation in macrophages stimulated with CIRP. Next, we observed that male C57BL/6 mice treated with C23 (8 mg/kg BW) at 2 h after cecal ligation and puncture (CLP) had lower serum levels of LDH, ALT, IL-6, TNF-α, and IL-1β (reduced by ≥39%) at 20 h after CLP compared with mice treated with vehicle...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29432179/parp-1-dependent-recruitment-of-cold-inducible-rna-binding-protein-promotes-double-strand-break-repair-and-genome-stability
#5
Jung-Kuei Chen, Wen-Ling Lin, Zhang Chen, Hung-Wen Liu
Maintenance of genome integrity is critical for both faithful propagation of genetic information and prevention of mutagenesis induced by various DNA damage events. Here we report cold-inducible RNA-binding protein (CIRBP) as a newly identified key regulator in DNA double-strand break (DSB) repair. On DNA damage, CIRBP temporarily accumulates at the damaged regions and is poly(ADP ribosyl)ated by poly(ADP ribose) polymerase-1 (PARP-1). Its dissociation from the sites of damage may depend on its phosphorylation status as mediated by phosphatidylinositol 3-kinase-related kinases...
February 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29421306/prenatal-cold-stress-effect-on-maternal-hippocampus-and-offspring-behavior-in-rats
#6
Shuai Lian, Di Wang, Bin Xu, Wenjin Guo, Lipeng Wang, Wenjie Li, Hong Ji, Jianfa Wang, Fanzhi Kong, Li Zhen, Shize Li, Liping Zhang, Jingru Guo, Huanmin Yang
In mammals, environmental factors including cold stress exert dramatic effects on adult health during late gestation, the cold stress response refers to an organism's response to cold. Indeed, cells and organs, including the hippocampus, are coordinated to respond to prevent hypothermia. The hippocampus act as an important brain structure that regulates the activity of the hypothalamic-pituitary-adrenal (HPA) axis, and suppress the stress reaction through feedback regulation of the HPA axis. To evaluate the response of the hippocampus during prenatal cold stress, we established a prenatal cold stress rat model...
July 2, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29388696/rbm3-expression-is-upregulated-by-nf-%C3%AE%C2%BAb-p65-activity-protecting-cells-from-apoptosis-during-mild-hypothermia
#7
Ayako Ushio, Ko Eto
The RNA-binding protein RBM3, a cold shock protein whose expression is elevated under hypothermic conditions, plays an important role in cell survival; however, little is known about the mechanism underlying the mild hypothermia-mediated regulation of RBM3 expression and apoptosis. Here we show that the transcription factor NF-κB p65 is phosphorylated at Ser276 and activates RBM3 gene transcription via binding to a particular element within the promoter region in response to induced hypothermia, elevating the protein expression, and suppressing apoptosis...
February 1, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29361038/cold-inducible-rna-binding-protein-cirp-induces-translation-of-the-cell-cycle-inhibitor-p27kip1
#8
Martina Roilo, Michael K Kullmann, Ludger Hengst
The CDK inhibitor p27Kip1 plays a central role in controlling cell proliferation and cell-cycle exit. p27Kip1 protein levels oscillate during cell-cycle progression and are regulated by mitogen or anti-proliferative signaling. The abundance of the protein is frequently determined by post-transcriptional mechanisms including ubiquitin-mediated proteolysis and translational control. Here, we report that the cold-inducible RNA-binding protein (CIRP) selectively binds to the 5' untranslated region of the p27Kip1 mRNA...
April 6, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29345380/cirp-increases-icam-1-phenotype-of-neutrophils-exhibiting-elevated-inos-and-nets-in-sepsis
#9
Yasumasa Ode, Monowar Aziz, Ping Wang
Sepsis represents uncontrolled inflammation due to an infection. Cold-inducible RNA-binding protein (CIRP) is a stress-induced damage-associated molecular pattern (DAMP). A subset of neutrophils expressing ICAM-1+ neutrophils was previously shown to produce high levels of reactive oxygen species. The role of CIRP for the development and function of ICAM-1+ neutrophils during sepsis is unknown. We hypothesize that CIRP induces ICAM-1 expression in neutrophils causing injury to the lungs during sepsis. Using a mouse model of cecal ligation and puncture (CLP)-induced sepsis, we found increased expression of CIRP and higher frequencies and numbers of ICAM-1+ neutrophils in the lungs...
January 17, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29330047/an-intrinsically-disordered-domain-in-polaribacter-irgensii-kopri-22228-cspb-confers-extraordinary-freeze-tolerance
#10
Youn Hong Jung, Ji-Hyun Uh, Kyunghee Lee, Hana Im
Organisms living in extremely cold environments possess mechanisms to survive low temperatures. Among the known cold-induced genes, cold-shock proteins (Csps) are the most prominent. A csp-homologous gene, cspBPi , has been cloned from the Arctic bacterium Polaribacter irgensii KOPRI 22228, and overexpression of this gene greatly increased the freezing tolerance of its host. This protein consists of a unique N-terminal domain and a well conserved C-terminal cold shock domain. To elucidate the detailed mechanisms involved in the extraordinary freeze-tolerance conferred by CspBPi , we identified the responsible domain by mutational analysis...
February 5, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29322631/cold-inducible-rna-binding-protein-in-cancer-and-inflammation
#11
REVIEW
Daniel A Lujan, Joey L Ochoa, Rebecca S Hartley
RNA binding proteins (RBPs) play key roles in RNA dynamics, including subcellular localization, translational efficiency and metabolism. Cold-inducible RNA binding protein (CIRP) is a stress-induced protein that was initially described as a DNA damage-induced transcript (A18 hnRNP), as well as a cold-shock domain containing cold-stress response protein (CIRBP) that alters the translational efficiency of its target messenger RNAs (mRNAs). This review summarizes recent work on the roles of CIRP in the context of inflammation and cancer...
March 2018: Wiley Interdisciplinary Reviews. RNA
https://www.readbyqxmd.com/read/29175331/involvement-of-trpv3-and-trpm8-ion-channel-proteins-in-induction-of-mammalian-cold-inducible-proteins
#12
Takanori Fujita, Yu Liu, Hiroaki Higashitsuji, Katsuhiko Itoh, Koji Shibasaki, Jun Fujita, Hiroyuki Nishiyama
Cold-inducible RNA-binding protein (CIRP), RNA-binding motif protein 3 (RBM3) and serine and arginine rich splicing factor 5 (SRSF5) are RNA-binding proteins that are transcriptionally upregulated in response to moderately low temperatures and a variety of cellular stresses in mammalian cells. Induction of these cold-inducible proteins (CIPs) is dependent on transient receptor potential (TRP) V4 channel protein, but seems independent of its ion channel activity. We herein report that in addition to TRPV4, TRPV3 and TRPM8 are necessary for the induction of CIPs...
January 1, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29146689/corrigendum-cold-inducible-rna-binding-protein-cirp-expression-is-modulated-by-alternative-mrnas
#13
Mohamed B Al-Fageeh, C Mark Smales
No abstract text is available yet for this article.
December 2017: RNA
https://www.readbyqxmd.com/read/29138350/the-dead-box-rna-helicase-rh50-is-a-23s-4-5s-rrna-maturation-factor-that-functionally-overlaps-with-the-plastid-signaling-factor-gun1
#14
Francesca Paieri, Luca Tadini, Nikolay Manavski, Tatjana Kleine, Roberto Ferrari, Piero Morandini, Paolo Pesaresi, Jörg Meurer, Dario Leister
DEAD-box RNA helicases (DBRHs) modulate RNA secondary structure, allowing RNA molecules to adopt the conformations required for interaction with their target proteins. RH50 is a chloroplast-located DBRH that colocalizes and is coexpressed with GUN1, a central factor in chloroplast-to-nucleus signaling. When combined with mutations that impair plastid gene expression ( prors1 - 1 , prpl11 - 1 , prps1 - 1 , prps21 - 1 , prps17 - 1 , and prpl24 - 1 ), rh50 and gun1 mutations evoke similar patterns of epistatic effects...
January 2018: Plant Physiology
https://www.readbyqxmd.com/read/29134130/recent-progress-in-the-research-of-cold-inducible-rna-binding-protein
#15
REVIEW
Peng Zhong, He Huang
Cold-inducible RNA-binding protein (CIRP) is a cold-shock protein which can be induced after exposure to a moderate cold-shock in different species ranging from amphibians to humans. Expression of CIRP can also be regulated by hypoxia, UV radiation, glucose deprivation, heat stress and H2 O2 , suggesting that CIRP is a general stress-response protein. In response to stress, CIRP can migrate from the nucleus to the cytoplasm and regulate mRNA stability through its binding site on the 3'-UTR of its targeted mRNAs...
November 2017: Future Science OA
https://www.readbyqxmd.com/read/29099744/low-temperature-extends-the-lifespan-of-bursaphelenchus-xylophilus-through-the-cgmp-pathway
#16
Bowen Wang, Ling Ma, Feng Wang, Buyong Wang, Xin Hao, Jiayao Xu, Yan Ma
The causal agent of pine wilt disease, pine wood nematode (PWN) ( Bursaphelenchus xylophilus ), revealed extended lifespan at low temperature. To discover the molecular mechanism of this phenomenon, we attempted to study the molecular characterization, transcript abundance, and functions of three genes of the cyclic guanosine monophosphate (cGMP) pathway from B. xylophilus . Three cGMP pathway genes were identified from B. xylophilus . Bioinformatic software was utilized to analyze the characteristics of the three putative proteins...
November 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29049808/cold-inducible-ribonucleic-acid-binding-protein-attenuates-acute-kidney-injuries-after-deep-hypothermic-circulatory-arrest-in-rats
#17
Lei Yu, Tianxiang Gu, Yu Liu, Xuan Jiang, Enyi Shi
OBJECTIVES: Cold-inducible ribonucleic acid-binding protein (CIRP) has been identified to play a role in the antiapoptotic effect of hypothermia. We sought to investigate the renoprotection of CIRP in a rat model of deep hypothermic circulatory arrest. METHODS: Overexpression and knockdown of CIRP were achieved in vivo by directly injecting lentivirus vectors containing packaging lentivirus (pL)/internal ribosome entry site (IRES)/green fluorescent protein (GFP)-CIRP or pL/short hairpin RNA (shRNA)/F-cold inducible RNA binding protein (F-CIRP)-A into the renal parenchyma of rats 7 days before deep hypothermic circulatory arrest under the ultrasound guidance...
January 1, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28970281/rna-binding-protein-ybx2-regulates-rna-stability-during-cold-induced-brown-fat-activation
#18
Dan Xu, Shaohai Xu, Aung Maung Maung Kyaw, Yen Ching Lim, Sook Yoong Chia, Diana Teh Chee Siang, Juan R Alvarez-Dominguez, Peng Chen, Melvin Khee-Shing Leow, Lei Sun
Recent years have seen an upsurge of interest in brown adipose tissue (BAT) to combat the epidemic of obesity and diabetes. How its development and activation are regulated at the posttranscriptional level, however, has yet to be fully understood. RNA binding proteins (RBPs) lie in the center of posttranscriptional regulation. To systemically study the role of RBPs in BAT, we profiled >400 RBPs in different adipose depots and identified Y-box binding protein 2 (Ybx2) as a novel regulator in BAT activation...
December 2017: Diabetes
https://www.readbyqxmd.com/read/28930962/attenuation-of-hemorrhage-associated-lung-injury-by-adjuvant-treatment-with-c23-an-oligopeptide-derived-from-cold-inducible-rna-binding-protein
#19
Fangming Zhang, Weng-Lang Yang, Max Brenner, Ping Wang
BACKGROUND: Hemorrhagic shock (HS) is an important cause of mortality. HS is associated with an elevated incidence of acute lung injury and acute respiratory distress syndrome, significantly contributing to HS morbidity and mortality. Cold-inducible RNA-binding protein (CIRP) is released into the circulation during HS and can cause lung injury. C23 is a CIRP-derived oligopeptide that binds with high affinity to the CIRP receptor and inhibits CIRP-induced phagocyte secretion of TNF-α...
October 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28930914/the-protective-effect-of-a-short-peptide-derived-from-cold-inducible-rna-binding-protein-in-renal-ischemia-reperfusion-injury
#20
Joseph McGinn, Fangming Zhang, Monowar Aziz, Weng-Lang Yang, Jeffrey Nicastro, Gene F Coppa, Ping Wang
Extracellular cold-inducible RNA-binding protein (CIRP) functions as damage-associated molecular pattern and has been demonstrated to be responsible in part for the damage occurring after renal ischemia-reperfusion (I/R). A short peptide derived from CIRP, named C23, binds to myeloid differentiation factor 2, a Toll-like receptor 4 coreceptor. We hypothesize that C23 reduces renal ischemia-reperfusion (RIR) injury by blocking CIRP. We observed that pretreatment with C23 significantly decreased the levels of recombinant mouse CIRP-induced tumor necrosis factor-α (TNF-α) in a dose-dependent fashion in cultured macrophages...
March 2018: Shock
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