keyword
https://read.qxmd.com/read/38420877/breast-cancer-screening-in-the-intermediate-risk-population-falling-through-the-cracks
#1
REVIEW
Kaitlin M Zaki-Metias, Huijuan Wang, Tima F Tawil, Eda B Miles, Lisa Deptula, Pooja Agrawal, Katie M Davis, Lucy B Spalluto, Jean M Seely, Charlotte J Yong-Hing
Breast cancer screening guidelines vary for women at intermediate risk (15%-20% lifetime risk) for developing breast cancer across jurisdictions. Currently available risk assessment models have differing strengths and weaknesses, creating difficulty and ambiguity in selecting the most appropriate model to utilize. Clarifying which model to utilize in individual circumstances may help determine the best screening guidelines to use for each individual.
February 29, 2024: Canadian Association of Radiologists Journal
https://read.qxmd.com/read/38399352/retracted-fahmy-et-al-intranasal-niosomal-in-situ-gel-as-a-promising-approach-for-enhancing-flibanserin-bioavailability-and-brain-delivery-in-vitro-optimization-and-ex-vivo-in-vivo-evaluation-pharmaceutics-2020-12-485
#2
Usama A Fahmy, Shaimaa M Badr-Eldin, Osama A A Ahmed, Hibah M Aldawsari, Singkome Tima, Hani Z Asfour, Mohammed W Al-Rabia, Aya A Negm, Muhammad H Sultan, Osama A A Madkhali, Nabil A Alhakamy
This journal retracts the article "Intranasal Niosomal In Situ Gel as a Promising Approach for Enhancing Flibanserin Bioavailability and Brain Delivery: In Vitro Optimization and Ex Vivo/In Vivo Evaluation" [...].
January 29, 2024: Pharmaceutics
https://read.qxmd.com/read/38364755/clival-chordoma-presenting-with-isolated-unilateral-cranial-nerve-xii-palsy-a-case-report
#3
Nahar Ismaiel, Leen Jaloud, Tima Barhoum, Rami Issa, Zuheir Alshehabi
INTRODUCTION: Chordomas are rare malignant neoplasms that can originate anywhere along the cerebrospinal axis. However, they are most commonly found in the spine, cranium, and sacrococcygeal region. Chordomas can manifest differently depending on their location and most symptoms are a result of local invasion. We present a rare case of intracranial clival chordoma that manifested as isolated unilateral cranial nerve XII (CN XII) palsy. PRESENTATION: A 53-year-old male presented to the neurosurgical clinic with headaches, dysarthria, and pharyngeal pain...
February 15, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38295279/retraction-of-marine-macroalgal-polygalactan-built-nanoparticle-construct-for-osteogenesis
#4
Kajal Chakraborty, Tima Antony, Shubhajit Dhara
No abstract text is available yet for this article.
January 31, 2024: Biomacromolecules
https://read.qxmd.com/read/38232908/targeting-cd38-cyclic-adp-ribosyl-cyclase-as-a-novel-therapeutic-strategy-for-identification-of-three-potent-agonists-for-leukopenia-treatment
#5
JOURNAL ARTICLE
Yuanzhi Liu, Linwei Zhang, Long Wang, Xiaoqing Tang, Shengli Wan, Qianqian Huang, Mei Ran, Hongping Shen, Yan Yang, Sawitree Chiampanichayakul, Singkome Tima, Songyot Anuchapreeda, Jianming Wu
Leukopenia is the most common side effect of chemotherapy and radiotherapy. It potentially deteriorates into a life-threatening complication in cancer patients. Despite several agents being approved for clinical administration, there are still high incidences of pathogen-related disease due to a lack of functional immune cells. ADP-ribosyl cyclase of CD38 displays a regulatory effect on leukopoiesis and the immune system. To explore whether the ADP-ribosyl cyclase was a potential therapeutic target of leukopenia...
January 15, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38166788/anticancer-activity-of-curcuma-aeroginosa-essential-oil-and-its-nano-formulations-cytotoxicity-apoptosis-and-cell-migration-effects
#6
JOURNAL ARTICLE
Pawaret Panyajai, Natsima Viriyaadhammaa, Singkome Tima, Sawitree Chiampanichayakul, Pornngarm Dejkriengkraikul, Siriporn Okonogi, Songyot Anuchapreeda
BACKGROUND AND AIMS: Curcuma aeruginosa, commonly known as "kha-min-dam" in Thai, holds significance in Asian traditional medicine due to its potential in treating various diseases, having properties such as anti-HIV, hepatoprotective, antimicrobial and anti-androgenic activities. This study explores the anticancer activity of C. aeruginosa essential oil (CAEO) and its nano-formulations. METHODS: CAEO obtained from hydrodistillation of C. aeruginosa fresh rhizomes was examined by gas chromatography mass spectroscopy...
January 2, 2024: BMC complementary medicine and therapies
https://read.qxmd.com/read/37965300/integrative-systematics-and-biogeography-of-the-hydrozoans-leptothecata-eirenidae-eirene-menoni-kramp-1953-and-eirene-lacteoides-kubota-and-horita-1992-from-japan-and-china-with-comments-on-pacific-ocean-distributions
#7
JOURNAL ARTICLE
Gerald L Crow, Brenden S Holland, Gaku Yamamoto, Shuhei Ikeda, Aya Adachi, Kelley Niide
The hydrozoan family Eirenidae is known scientifically for its morphological plasticity and challenges in species identification. We used an integrative taxonomic approach based on morphological, molecular and life history evidence to systematically assess field-collected medusae of Eirene menoni Kramp 1953 and captive raised polyps of both E. menoni and E. lacteoides Kubota and Horita 1992. Following morphological review, we updated the genus description to include the presence of rudimentary bulbs (warts) on the ring canal in at least eight of the 24 valid Eirene species...
2023: Zoological Studies (Taipei, Taiwan)
https://read.qxmd.com/read/37740609/economic-evaluation-of-prostate-cancer-risk-assessment-methods-a-cost-effectiveness-analysis-using-population-data
#8
JOURNAL ARTICLE
Tima Mohammadi, Daphne P Guh, Alexander C T Tam, Reka E Pataky, Peter C Black, Alan So, Larry D Lynd, Wei Zhang, Annalijn I Conklin
BACKGROUND: The current prostate cancer (PCa) screening standard of care (SOC) leads to unnecessary biopsies and overtreatment because decisions are guided by prostate-specific antigen (PSA) levels, which have low specificity in the gray zone (3-10 ng/mL). New risk assessment tools (RATs) aim to improve biopsy decision-making. We constructed a modeling framework to assess new RATs in men with gray zone PSA from the British Columbia healthcare system's perspective. METHODS: We evaluated the cost-effectiveness of a new RAT used in biopsy-naïve men aged 50+ with a PSA of 3-10 ng/mL using a time-dependent state-transition model...
September 23, 2023: Cancer Medicine
https://read.qxmd.com/read/37567322/cd3%C3%AE-as-a-novel-predictive-biomarker-of-pd-1-inhibitor-resistance-in-melanoma
#9
JOURNAL ARTICLE
Zhuo Zhang, Duoli Zhang, Fang Wang, Jiao Liu, Xian Jiang, Songyot Anuchapreeda, Singkome Tima, Zhangang Xiao, Suwit Duangmano
Malignant melanoma is the most lethal form of skin cancer, and its incidence rates are increasing in Europe, America, and Oceania countries. Despite immune checkpoint inhibitors, such as PD-1 inhibitors, have been shown to have significant therapeutic effects on malignant melanoma, many patients are unresponsive to these treatments, even emerged resistance. There is an urgent need to discover novel biomarkers that might distinguish resistant patients from responders. In this study, we used a series of bioinformatics analyses and experimental validation...
August 9, 2023: Molecular and Cellular Probes
https://read.qxmd.com/read/37491490/element-distribution-of-grading-in-red-mud-at-different-temperatures-based-on-tima-and-eds-analysis
#10
JOURNAL ARTICLE
Dandan Huang, Yanxiu Wang, Chengwen Wang, Le Tao, Xiangsong Meng, Li Wang, Wei Sun
In this paper, element distribution patterns of red mud particles with different grading temperatures were explored based on TIMA and EDS, and alkali removal performance of different particle sizes under high temperature grading was compared. The results show that non-clay phases in the particles coagulate with the clay phases of different sodium contents during stacking process, thus forming a mixture phase containing clay phase and other impurities. The potential of grading utilization of red mud is displayed by process mineralogy studies...
July 25, 2023: Environmental Science and Pollution Research International
https://read.qxmd.com/read/37476131/delayed-presentation-of-a-nonunion-of-the-distal-femur-associated-with-a-missed-popliteal-artery-injury-a-case-report
#11
Xavier Penda, Henry Ndasi, Ghislain Aminake, Serge Tima
Popliteal artery injuries are known complications of distal femur fractures, often leading to life-threatening consequences. The authors present a case of a four-month-old missed popliteal artery injury complicating a nonunion of the distal femur. The patient, a 28-year-old male, initially sought alternative treatment after a bike accident but experienced persistent pain and functional limitations. During our clinical evaluation, the possibility of a popliteal artery injury was considered but not definitively ruled out...
June 2023: Curēus
https://read.qxmd.com/read/37426617/a-transcriptomic-evaluation-of-the-mechanism-of-programmed-cell-death-of-the-replaceable-bud-in-chinese-chestnut
#12
JOURNAL ARTICLE
Yan Guo, Shuhang Zhang, Ying Li, Xinfang Zhang, Huan Liu, Shiyuan Liu, Jing Liu, Guangpeng Wang
Previous studies suggest that the senescence and death of the replaceable bud of the Chinese chestnut cultivar (cv.) "Tima Zhenzhu" involves programmed cell death (PCD). However, the molecular network regulating replaceable bud PCD is poorly characterized. Here, we performed transcriptomic profiling on the chestnut cv. "Tima Zhenzhu" replaceable bud before (S20), during (S25), and after (S30) PCD to unravel the molecular mechanism underlying the PCD process. A total of 5,779, 9,867, and 2,674 differentially expressed genes (DEGs) were discovered upon comparison of S20 vs S25, S20 vs S30, and S25 vs S30, respectively...
2023: Open Life Sciences
https://read.qxmd.com/read/37355557/engineering-cell-lines-for-specific-human-leukocyte-antigen-presentation
#13
JOURNAL ARTICLE
Dongbin Jin, Khai Lee Loh, Tima Shamekhi, Yi Tian Ting, Terry C C Lim Kam Sian, James Roest, Joshua D Ooi, Julian P Vivian, Pouya Faridi
Epitope-specific immunotherapies have enabled the targeted treatment of a variety of diseases, ranging from cancer, infection, and autoimmune disorders. For CD8+ T cell-based therapies, the precise identification of immunogenic peptides presented by human leukocyte antigen (HLA) class I is essential which can be achieved by immunopeptidomics. Here, using lentivirus-mediated transduction and cell sorting approaches, we present a method to engineer a cell line that does not express its native HLA but instead expresses an HLA of interest (in this instance HLA-A*02:01)...
2023: Methods in Molecular Biology
https://read.qxmd.com/read/37339456/the-role-of-68ga-fapi-pet-ct-in-breast-cancer-response-assessment-and-follow-up
#14
JOURNAL ARTICLE
Yael Eshet, Noam Tau, Keren Levanon, Rinat Bernstein-Molho, Ofer Globus, Amit Itay, Tal Shapira, Cecilie Oedegaard, Michal Eifer, Tima Davidson, Meital Nidam, Einav Gal-Yam, Liran Domachevsky
PURPOSE: 68Ga-fibroblast activation protein inhibitor (FAPI), a new PET/CT radiotracer targeting cancer-associated fibroblasts in tumor microenvironment, can detect many types of cancer. We aimed to assess whether it can also be used for response assessment and follow-up. METHODS: We followed up patients with FAPI-avid invasive lobular breast cancer (ILC) before and after treatment changes and correlated qualitative maximal intensity projection images and quantitative tumor volume with CT results and blood tumor biomarkers...
June 19, 2023: Clinical Nuclear Medicine
https://read.qxmd.com/read/37334365/saprim-a-semi-automated-protocol-for-mid-throughput-immunopeptidomics
#15
JOURNAL ARTICLE
Terry C C Lim Kam Sian, Gabriel Goncalves, Joel R Steele, Tima Shamekhi, Liesl Bramberger, Dongbin Jin, Mohammad Shahbazy, Anthony W Purcell, Sri Ramarathinam, Stoyan Stoychev, Pouya Faridi
Human leukocyte antigen (HLA) molecules play a crucial role in directing adaptive immune responses based on the nature of their peptide ligands, collectively coined the immunopeptidome. As such, the study of HLA molecules has been of major interest in the development of cancer immunotherapies such as vaccines and T-cell therapies. Hence, a comprehensive understanding and profiling of the immunopeptidome is required to foster the growth of these personalised solutions. We herein describe SAPrIm, an Immunopeptidomics tool for the Mid-Throughput era...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37322398/using-multi-technology-to-characterize-transboundary-hg-pollution-in-the-largest-presently-active-hg-deposit-in-china
#16
JOURNAL ARTICLE
Taoran Shi, Pei Zhan, Yaqin Shen, Hongyan Wang, Chunfa Wu, Jining Li
Active Hg mines are primary sources of Hg contamination in the environment of mining districts and surrounding areas. Alleviation of Hg pollution requires knowledge of pollution sources, migration, and transform pathways across various environmental media. Accordingly, the Xunyang Hg-Sb mine, the largest active Hg deposit in China, presently was selected as the study area. GIS, TIMA, EPMA, μ-XRF, TEM-EDS, and Hg stable isotopes were adopted to investigate the spatial distribution, mineralogical characteristics, in situ microanalysis, and pollution sources of Hg in the environment medium at the macro- and micro-levels...
June 15, 2023: Environmental Science and Pollution Research International
https://read.qxmd.com/read/37296375/biological-activities-of-extracts-and-compounds-from-thai-kae-lae-maclura-cochinchinensis-lour-corner
#17
JOURNAL ARTICLE
Lapamas Rueankham, Pawaret Panyajai, Aroonchai Saiai, Methee Rungrojsakul, Singkome Tima, Sawitree Chiampanichayakul, Kankanit Yeerong, Suvimol Somwongin, Wantida Chaiyana, Pornngarm Dejkriengkraikul, Siriporn Okonogi, Trinnakorn Katekunlaphan, Songyot Anuchapreeda
BACKGROUND AND AIMS: The purpose of this study was to investigate the biological properties of Kae-Lae (Maclura cochinchinensis (Lour.) Corner), a traditional medicinal plant used in Ayurvedic recipes in Thailand. To achieve this objective, heartwood samples were collected from 12 sources across Thailand. Fractional extracts (n-hexane, ethyl acetate, and ethanol) and the dominant compounds (morin, resveratrol, and quercetin) were examined for their abilities on cytotoxicity, antioxidant, anti-inflammation, and antileukaemic activity (Wilms' tumour 1 protein was used as a well-known biomarker for leukaemic cell proliferation)...
June 9, 2023: BMC complementary medicine and therapies
https://read.qxmd.com/read/37293575/enhanced-cosmeceutical-potentials-of-the-oil-from-gryllus-bimaculatus-de-geer-by-nanoemulsions
#18
JOURNAL ARTICLE
Wantida Chaiyana, Sudarat Jiamphun, Suchanan Bezuidenhout, Kankanit Yeerong, Nutnicha Krueathanasing, Pattiya Thammasorn, Pipat Jittasai, Suphachai Tanakitvanicharoen, Singkome Tima, Songyot Anuchapreeda
PURPOSE: This study aimed to extract the oil from Gryllus bimaculatus de Geer, evaluate its potential for cosmeceutical applications, and develop nanoemulsions to promote the cosmeceutical capabilities of the oil. METHODS: G. bimaculatus oil was produced by the cold pressing method. Its fatty acid compositions were assessed by fatty acid methyl ester/gas chromatographic-mass spectrometry. The antioxidant activities of the oil were investigated in terms of radical scavengers, reducing power, and lipid peroxidation inhibition...
2023: International Journal of Nanomedicine
https://read.qxmd.com/read/37278194/mitigating-neutrophil-trafficking-and-cardiotoxicity-with-ds-ikl-in-a-microphysiological-system-of-a-cytokine-storm
#19
JOURNAL ARTICLE
Venktesh S Shirure, Sergey Yechikov, Bhupinder S Shergill, Tima Dehghani, Anton V Block, Harkanwalpreet Sodhi, Alyssa Panitch, Steven C George
A feature of severe COVID-19 is the onset of an acute and intense systemic inflammatory response referred to as the "cytokine storm". The cytokine storm is characterized by high serum levels of inflammatory cytokines and the subsequent transport of inflammatory cells to damaging levels in vital organs ( e.g. , myocarditis). Immune trafficking and its effect on underlying tissues ( e.g. , myocardium) are challenging to observe at a high spatial and temporal resolution in mouse models. In this study, we created a vascularized organ-on-a-chip system to mimic cytokine storm-like conditions and tested the effectiveness of a novel multivalent selectin-targeting carbohydrate conjugate (composed of DS - dermatan sulfate and IkL - a selectin-binding peptide, termed DS-IkL) in blocking infiltration of polymorphonuclear leukocytes (PMN)...
June 6, 2023: Lab on a Chip
https://read.qxmd.com/read/37240397/the-prognostic-value-of-anti-pla2r-antibodies-levels-in-primary-membranous-nephropathy
#20
JOURNAL ARTICLE
Olga Lesya Kukuy, Ron Cohen, Boris Gilburd, Eleanor Zeruya, Talia Weinstein, Timna Agur, Dganit Dinour, Pazit Beckerman, Alexander Volkov, Johnatan Nissan, Tima Davidson, Howard Amital, Yehuda Shoenfeld, Ora Shovman
Anti-PLA2R antibodies (Ab) are a diagnostic and prognostic biomarker in primary membranous nephropathy (PMN). We assessed the relationship between the levels of anti-PLA2R Ab at diagnosis and different variables related to disease activity and prognosis in a western population of PMN patients. Forty-one patients with positive anti-PLA2R Ab from three nephrology departments in Israel were enrolled. Clinical and laboratory data were collected at diagnosis and after one year of follow-up, including serum anti-PLA2R Ab levels (ELISA) and glomerular PLA2R deposits on biopsy...
May 21, 2023: International Journal of Molecular Sciences
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