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https://www.readbyqxmd.com/read/28712627/testing-the-external-validity-of-a-discrete-choice-experiment-method-an-application-to-latent-tuberculosis-infection-treatment
#1
Tima Mohammadi, Nick Bansback, Fawziah Marra, Amir Khakban, Jonathon R Campbell, J Mark FitzGerald, Larry D Lynd, Carlo A Marra
OBJECTIVES: To explore the external validity and predictive power of stated preferences obtained from a discrete choice experiment (DCE) by comparing the predicted behavior of respondents to their actual choices at an individual level. METHODS: A DCE was performed in patients before being offered treatment for latent tuberculosis infection. A mixed logit model was estimated using hierarchical Bayes. The individual-specific preference coefficients were used to calculate the expected probability of choosing the treatment by each patient...
July 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28707580/doxorubicin-loaded-micelle-targeting-muc1-a-potential-therapeutics-for-triple-negative-breast-cancer-treatment
#2
Supang Khondee, Chuda Chittasupho, Singkome Tima, Songyot Anuchapreeda
BACKGROUND: Triple negative breast cancer (TNBC) is an aggressive disease associated with poor prognosis and lack of validated targeted therapy. Thus chemotherapy is a main adjuvant treatment for TNBC patients, but it associates with severe toxicities. For a better treatment outcome, we developed an alternative therapeutic, doxorubicin (DOX)-loaded micelles targeting human mucin1 protein (MUC1) that is less toxic, more effective and targeted to TNBC. METHODS: From many candidate peptides, QNDRHPR-GGGSK (QND) and HSQLPQV-GGGSK (HSQ), were identified computationally, synthesized and purified using solid phase peptide synthesis and semi-preparative HPLC...
July 12, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28584146/a-targeted-metabolomics-analysis-identifies-intestinal-microbiota-derived-urinary-biomarkers-of-colonization-resistance-in-antibiotic-treated-mice
#3
Mark E Obrenovich, Mary Ann Tima, Alex Polinkovsky, Renliang Zhang, Steven N Emancipator, Curtis J Donskey
Antibiotics excreted into the intestinal tract may disrupt the microbiota that provide colonization resistance against enteric pathogens and alter normal metabolic functions of the microbiota. Many of the bacterial metabolites produced in the intestinal tract are absorbed systemically and excreted in urine. Here, we used a mouse model to test the hypothesis that alterations in levels of targeted bacterial metabolites in urine specimens could provide useful biomarkers indicating disrupted or intact colonization resistance...
June 5, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28573218/effect-of-thai-saraphi-flower-extracts-on-wt1-and-bcr-abl-protein-expression-in-leukemic-cell-lines
#4
Rungkarn Sangkaruk, Methee Rungrojsakul, Singkome Tima, Songyot Anuchapreeda
BACKGROUND: Saraphi (Mammea siamensis) is a Thai traditional herb. In this study, the cytotoxic effects of crude ethanolic and fractional extracts including hexane, ethyl acetate, and methanol fractions from M. siamensis flowers were investigated in order to determine their effect on WT1 expression in Molt4 and K562 cells and Bcr/Abl expression in K562 cells. MATERIALS AND METHODS: The flowers of M. siamensis were extracted using ethanol. The ethanol flower extract was further fractionated with hexane, ethyl acetate, and methanol...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28368101/a-rapid-analysis-of-variations-in-conformational-behavior-during-dihydrofolate-reductase-catalysis
#5
Robert L Hughes, Luke A Johnson, Enas M Behiry, E Joel Loveridge, Rudolf K Allemann
Protein flexibility is central to enzyme catalysis, yet it remains challenging both to predict conformational behavior on the basis of analysis of amino acid sequence and protein structure and to provide the necessary breadth of experimental support to any such predictions. Here a generic and rapid procedure for identifying conformational changes during dihydrofolate reductase (DHFR) catalysis is described. Using DHFR from Escherichia coli (EcDHFR), selective side-chain (13)C labeling of methionine and tryptophan residues is shown to be sufficient to detect the closed-to-occluded conformational transition that follows the chemical step in the catalytic cycle, with clear chemical shift perturbations found for both methionine methyl and tryptophan indole groups...
April 18, 2017: Biochemistry
https://www.readbyqxmd.com/read/28089916/stable-curcumin-loaded-polymeric-micellar-formulation-for-enhancing-cellular-uptake-and-cytotoxicity-to-flt3-overexpressing-eol-1-leukemic-cells
#6
Singkome Tima, Songyot Anuchapreeda, Chadarat Ampasavate, Cory Berkland, Siriporn Okonogi
The present study aims to develop a stable polymeric micellar formulation of curcumin (CM) with improved solubility and stability, and that is suitable for clinical applications in leukemia patients. CM-loaded polymeric micelles (CM-micelles) were prepared using poloxamers. The chemical structure of the polymers influenced micellar properties. The best formulation of CM-micelles, namely CM-P407, was obtained from poloxamer 407 at drug to polymer ratio of 1:30 and rehydrated with phosphate buffer solution pH 7...
January 12, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28061904/classifying-high-risk-versus-very-high-risk-prostate-cancer-is-it-relevant-to-outcomes-of-conformal-radiotherapy-and-androgen-deprivation
#7
Akram Saad, Jeffrey Goldstein, Yaacov R Lawrence, Benjamin Spieler, Raya Leibowitz-Amit, Raanan Berger, Tima Davidson, Damien Urban, Lev Tsang, Dror Alezra, Ilana Weiss, Zvi Symon
OBJECTIVE: To evaluate outcomes in prostate cancer patients classified as high-risk (HR) or very high-risk (VHR) who were treated with conformal radiation therapy (CRT) and androgen deprivation therapy (ADT). METHODS: Between 11/2001 and 3/2012, 203 patients with HR disease received CRT to the prostate (78-82 Gy) and pelvic lymph nodes (46-50 Gy) with ADT (6 m-2 years). Median follow-up was 50 months (12 m-142 m). Biochemical failure was defined according to Phoenix definition...
January 6, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28036254/targeted-delivery-of-nano-ptx-to-the-brain-tumor-associated-macrophages
#8
Lei Zou, Youhua Tao, Gregory Payne, Linh Do, Tima Thomas, Juan Rodriguez, Huanyu Dou
Nanoparticles containing mixed lipid monolayer shell, biodegradable polymer core and rabies virus glycoprotein (RVG) peptide as brain targeting ligand, were developed for brain targeted delivery of paclitaxel (PTX) to treat malignant glioma. RVG conjugated PTX loaded NPs (RVG-PTX-NPs) had the desirable size (~140 nm), narrow size distribution and spherical shape. RVG-PTX-NPs showed poor uptake by neurons and selective targeting to the brain tumor associated macrophages (TAMs) with controlled release and tumor specific toxicity...
January 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28010810/conventional-and-novel-body-temperature-measurement-during-rest-and-exercise-induced-hyperthermia
#9
COMPARATIVE STUDY
Colin Towey, Chris Easton, Robert Simpson, Charles Pedlar
Despite technological advances in thermal sensory equipment, few core temperature (TCORE) measurement techniques have met the established validity criteria in exercise science. Additionally, there is debate as to what method serves as the most practically viable, yet upholds the proposed measurement accuracy. This study assessed the accuracy of current and novel TCORE measurement techniques in comparison to rectal temperature (TREC) as a reference standard. Fifteen well-trained subjects (11 male, 4 female) completed 60min of exercise at an intensity equating to the lactate threshold; measured via a discontinuous exercise test...
January 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/27917595/societal-preferences-in-the-treatment-of-pediatric-medulloblastoma-balancing-risk-of-death-and-quality-of-life
#10
Amir Khakban, Tima Mohammadi, Larry D Lynd, Don Mabbott, Eric Bouffet, Louise Gastonguay, Zafar Zafari, David Malkin, Michael Taylor, Carlo A Marra
PURPOSE: Medulloblastoma is the most prevalent childhood brain cancer. Children with medulloblastoma typically receive a combination of surgery, radiation, and chemotherapy. The survival rate is high but survivors often have sequelae from radiotherapy of the entire developing brain and spinal cord. Ongoing genetic studies have suggested that decreasing the dose of radiation might be possible among children with favorable molecular variants; however, this may result in an increased disease recurrence...
June 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27879591/comparison-of-endothelial-differentiation-capacities-of-human-and-rat-adipose-derived-stem-cells
#11
COMPARATIVE STUDY
Hakan Orbay, Kamaljit Devi, Priscilla A Williams, Tima Dehghani, Eduardo A Silva, David E Sahar
BACKGROUND: The authors compared the endothelial differentiation capacities of human and rat adipose-derived stem cells to determine whether human adipose-derived stem cells can be a source of endothelial cells clinically. METHODS: Human and rat adipose-derived stem cells were harvested and characterized with flow cytometry and trilineage differentiation. Cells from passages III through V were fed with endothelial cell differentiation medium for up to 3 weeks. Cells were harvested after 1, 2, and 3 weeks, and endothelial differentiation was evaluated with quantitative reverse-transcriptase polymerase chain reaction, flow cytometry, and angiogenic sprouting assays...
December 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27855374/inflammatory-properties-and-adjuvant-potential-of-synthetic-glycolipids-homologous-to-mycolate-esters-of-the-cell-wall-of-mycobacterium-tuberculosis
#12
Hermann Giresse Tima, Juma''a Raheem Al Dulayymi, Olivier Denis, Pauline Lehebel, Klarah Sherzad Baols, Mohsin Omar Mohammed, Laurent L'Homme, Mohaned Mohammed Sahb, Georges Potemberg, Sylvie Legrand, Roland Lang, Rudi Beyaert, Jacques Piette, Mark Stephen Baird, Kris Huygen, Marta Romano
The cell wall of mycobacteria is characterised by glycolipids composed of different classes of mycolic acids (MAs; alpha-, keto-, and methoxy-) and sugars (trehalose, glucose, and arabinose). Studies using mutant Mtb strains have shown that the structure of MAs influences the inflammatory potential of these glycolipids. As mutant Mtb strains possess a complex mixture of glycolipids, we analysed the inflammatory potential of single classes of mycolate esters of the Mtb cell wall using 38 different synthetic analogues...
2017: Journal of Innate Immunity
https://www.readbyqxmd.com/read/27820686/letter-to-the-editor
#13
Marina de Deus Moura de Lima, Heloísa Clara Santos Sousa, Lúcia de F Tima Almeida de Deus Moura
No abstract text is available yet for this article.
November 2016: Operative Dentistry
https://www.readbyqxmd.com/read/27768632/long-term-imaging-of-the-lungs-after-sealant-bronchoscopic-lung-volume-reduction
#14
Sivan Lieberman, Tiberiu R Shulimzon, Tima Davidson, Edith M Marom
PURPOSE: The aim of the study was to assess the pulmonary temporal changes after bronchoscopic lung volume reduction (BLVR) using sealants for treatment of emphysema. MATERIALS AND METHODS: We retrospectively assessed all chest computerized tomography (CT) and F-18 fluorodeoxyglucose (FDG) positron emission tomography CT scans of patients treated at our institution with BLVR. RESULTS: Eleven patients were treated with sealants: 4 with biological sealants and 7 with synthetic sealants...
November 2016: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/27751588/development-and-characterization-of-flt3-specific-curcumin-loaded-polymeric-micelles-as-a-drug-delivery-system-for-treating-flt3-overexpressing-leukemic-cells
#15
Singkome Tima, Siriporn Okonogi, Chadarat Ampasavate, Chad Pickens, Cory Berkland, Songyot Anuchapreeda
This study aimed at developing a curcumin (CM) nanoparticle targeted to Feline McDonough Sarcoma (FMS)-like tyrosine kinase 3 (FLT3) protein on the surface of leukemic cells and at evaluating their properties, specificity, cytotoxicity, and inhibitory effect on FLT3 protein level in FLT3-overexpressing leukemic cells, EoL-1, and MV-4-11 cells. FLT3-specific peptides were conjugated onto modified poloxamer 407 using the copper-catalyzed azide-alkyne cycloaddition reaction. The thin film hydration method was performed for FLT3-specific CM-loaded polymeric micelles (FLT3-CM-micelles) preparation...
December 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27727129/recombinant-bacillus-subtilis-spores-for-the-delivery-of-mycobacterium-tuberculosis-ag85b-cfp10-secretory-antigens
#16
Kishore Das, Tima Thomas, Omar Garnica, Subramanian Dhandayuthapani
Tuberculosis continues to be a great cause of morbidity and mortality in different parts of the world. Unfortunately, the current BCG vaccine being administered is not fully protective against tuberculosis; therefore, there is a great need for alternate vaccines. With an aim to develop such vaccines, we have analyzed the utility of Bacillus subtilis spores for the expression of two major immunodominant antigens of Mycobacterium tuberculosis, Ag85B and CFP10. We created three recombinant B. subtilis strains to express a truncated fusion of Ag85B191-325 and CFP101-70 antigens (T85BCFP), either on the spore coat (MTAG1 strain) or in the cytosol of B...
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27462912/deoxynivalenol-zearalenone-and-t-2-in-grain-based-swine-feed-in-hungary
#17
COMPARATIVE STUDY
Helga Tima, Anita Rácz, Zsuzsanna Guld, Csilla Mohácsi-Farkas, Gabriella Kiskó
Fusarium genera can produce trichothecenes like deoxynivalenol (DON), zearalenone (ZEN) and T-2 toxin, which can occur in feed cereal grains. Enzyme-linked immunosorbent assays (ELISA) tests of different Hungarian swine feedstuff proved that these mycotoxins were present. In this survey, 45 feed samples from 3 significant Hungarian swine feedstuff manufacturers were tested. ELISA methodology validation showed mean recovery rates in ranges from 85.3% to 98.1%, with intermediate precision of 86.9-96.9% and variation coefficients of 3...
December 2016: Food Additives & Contaminants. Part B, Surveillance
https://www.readbyqxmd.com/read/27218431/focal-fluorine-18-fluorodeoxyglucose-avid-parotid-findings-in-patients-with-lung-cancer-prevalence-and-characteristics
#18
Tima Davidson, Orna Komissar, Elinor Goshen, Bruria Shalmon, Bar Chikman, Alon Ben-Nun, Simona Ben-Haim
OBJECTIVE: Correct interpretation of incidental tumors is important to plan an appropriate treatment. We assessed the incidence and imaging characteristics of fluorine-18 fluorodeoxyglucose (F-FDG)-avid focal parotid findings (FPFs) in patients with lung cancer. PATIENTS AND METHODS: FPFs in PET-computed tomography reports of cancer patients were searched. Those with known parotid malignancies, lymphoma, and diffuse F-FDG uptake in the entire parotid gland were not included in the analysis...
September 2016: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27206681/innate-signaling-by-mycobacterial-cell-wall-components-and-relevance-for-development-of-adjuvants-for-subunit-vaccines
#19
Hermann Giresse Tima, Kris Huygen, Marta Romano
The recognition of pathogens by the innate immune system occurs through pathogen recognition receptors (PRRs). PRRs recognize conserved pathogen-associated molecular patterns (PAMPs), triggering the induction of inflammatory innate responses and contributing to the development of specific adaptive immune responses. A better understanding of PRRs signaling has led to the development of new adjuvants for subunit vaccines based on PRR agonists. This review focuses on the lipid PAMPs present in the cell wall of mycobacteria, with emphasis on the agonists of C-type lectin receptors...
May 20, 2016: Expert Review of Vaccines
https://www.readbyqxmd.com/read/27092665/metabolic-assessment-of-merkel-cell-carcinoma-the-role-of-18f-fdg-pet-ct
#20
Simona Ben-Haim, Jenny Garkaby, Natalia Primashvili, Elinor Goshen, Ronnie Shapira, Tima Davidson, Ora Israel, Ron Epelbaum
OBJECTIVES: Merkel cell carcinoma (MCC) is a rare aggressive skin tumor associated with a high mortality rate. The present study evaluated the role of fluorine-18 fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) in subsequent management of patients with MCC. METHODS: A total of 101 consecutive F-FDG PET/CT studies of 46 patients with MCC (28 men, 68±15.4 years) were retrospectively evaluated and the role in clinical care was documented. RESULTS: There were 40 positive studies (40%) in 28 patients (61%); of these, 33 studies (33%) in 27 patients (59%) showed metastatic disease...
August 2016: Nuclear Medicine Communications
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