keyword
https://read.qxmd.com/read/38310867/japanese-study-of-the-effects-of-amg-%C3%AE-1-microglobulin-reduction-rates-on-survival-jamreds-protocol-of-a-multicenter-prospective-observational-cohort-study
#1
JOURNAL ARTICLE
Toshihide Naganuma, Yoshiaki Takemoto, Naohiro Kamada, Daijiro Kabata, Ayumi Shintani, Keiko Ota, Jun Minakuchi, Ken Tsuchiya, Hideki Kawanishi
INTRODUCTION: Recent advances in dialysis therapy have made it possible to remove middle molecules. Removal of small-middle molecules, such as β2-microglobulin (BMG), can now be achieved with conventional hemodialysis, and removal of large-middle molecules has become a target, particularly for 1-microglobulin (AMG, 33 kD). The AMG reduction rate has emerged as a target for improvement of various clinical symptoms, but the effects on prognosis have yet to be determined. The "Japanese study of the effects of AMG (α1-microglobulin) reduction rates on survival" (JAMREDS) was started in April 2020, with the goal of determining if the AMG reduction rate associates with the risk of mortality and cardiovascular disease (CVD) events...
February 4, 2024: Blood Purification
https://read.qxmd.com/read/38170488/two-dimensional-oxygen-deficient-zno-1-x-nanosheet-as-a-highly-selective-and-sensitive-fluorescence-probe-for-ferritin-detection-the-electron-transfer-biosensor-etbs
#2
JOURNAL ARTICLE
Priyanka Rana, Sivakumar Musuvadhi Babulal, Hui-Fen Wu
Iron proteins are of great scientific interest due to their importance as an excellent biomarker for human diseases. Ferritin (Fe3+ ), being an iron-rich blood protein, is related to various diseases like anemia and cancer. For the first time, we have developed a highly sensitive and selective ferritin biosensor based on fluorescent oxygen-deficient zinc oxide nanosheets through hydrothermal and probe-ultrasonication combined methods. The fluorescence study showed an intense bluish-green fluorescence at λ ex = 370 nm, after optimization at different excitation wavelengths...
January 3, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38083960/tailoring-medical-treatment-in-pakistan-the-promise-of-precision-medicine
#3
JOURNAL ARTICLE
Fawad Mueen Arbi
No abstract text is available yet for this article.
December 2023: JPMA. the Journal of the Pakistan Medical Association
https://read.qxmd.com/read/38048475/cspm5-2-a-phosphate-transporter-protein-like-gene-promotes-powdery-mildew-resistance-in-cucumber
#4
JOURNAL ARTICLE
Jingxian Sun, Jingtao Nie, Tingting Xiao, Chunli Guo, Duo Lv, Keyan Zhang, Huan-Le He, Junsong Pan, Run Cai, Gang Wang
Powdery mildew (PM) is one of the most serious fungal diseases affecting cucumbers (Cucumis sativus L.). The mechanism of PM resistance in cucumber is intricate and remains fragmentary as it is controlled by several genes. In this study, we detected the major-effect Quantitative Trait Locus (QTL), PM5.2, involved in PM resistance by QTL mapping. Through fine mapping, the dominant PM resistance gene, CsPM5.2, was cloned and its function was confirmed by transgenic complementation and natural variation identification...
December 4, 2023: Plant Journal
https://read.qxmd.com/read/38033722/quantitative-mass-spectrometric-analysis-of-hepatocellular-carcinoma-biomarker-alpha-fetoprotein
#5
JOURNAL ARTICLE
Chen-Chun Chen, Han-Wen Huang, Bo-Rui Chen, Chi-Huey Wong
Serum alpha-fetoprotein (AFP) has been used as a marker for the diagnosis of hepatocellular carcinoma (HCC) and its core fucosylation is associated with the early stage of HCC. However, current methods for the detection of AFP with core fucose are not highly accurate for early diagnosis. In this study, we established an enzyme-assisted mass spectrometric method for the quantitative analysis of AFP/core fucose with high specificity and sensitivity. We employed endoglycosidase treatment of AFP to improve the biomarker analysis...
November 29, 2023: RSC chemical biology
https://read.qxmd.com/read/37807023/estimation-of-non-monotonic-transition-rates-in%C3%A2-a%C3%A2-semi-markov-process-with-covariates-adjustments-and%C3%A2-application-to-caregivers-stress-data
#6
JOURNAL ARTICLE
Esther Ngan, Wenyaw Chan, Luis Leon-Novelo, Valory Pavlik
With the large ongoing number of aged people and Alzheimer's disease (AD) patients worldwide, unpaid caregivers have become the primary sources of their daily caregiving. Alzheimer's family caregivers often suffer from physical and mental morbidities owing to various reasons. The aims of this paper were to develop alternate methods to understand the transition properties, the dynamic change, and the long-run behavior of AD caregivers' stress levels, by assuming their transition to the next level only depends on the duration of the current stress level...
October 8, 2023: Statistics in Medicine
https://read.qxmd.com/read/37771282/transpapillary-pancreatic-duct-stenting-in-the-treatment-of-acute-severe-pancreatitis-complicated-by-pancreatic-pseudocyst-compressing-portal-vein-leading-to-local-portal-hypertension
#7
JOURNAL ARTICLE
Jun Xie, Wei Chen, Hongming Liu
A 52-year-old male diagnosed with severe acute pancreatitis developed persistent abdominal distension and intermittent emesis six weeks after treatment. Computed tomography (CT) showed that the shape of the pancreas was not clear, and a pseudocyst (11.2*6.6 cm) existed in the tail of the pancreas, which compressed the portal vein and led to local portal hypertension. A transpapillary pancreatic duct stent (7F*9 cm) was successfully placed for drainage of fluid collection despite pancreatic duct obstruction, with one end into the pseudocyst cavity and the other into the duodenum...
September 29, 2023: Revista Española de Enfermedades Digestivas
https://read.qxmd.com/read/37739727/prevalence-of-malnutrition-among-older-adults-in-a-population-based-study-the-hunt-study
#8
JOURNAL ARTICLE
Marit Kolberg, Ingvild Paur, Yi-Qian Sun, Linda Gjøra, Håvard Kjesbu Skjellegrind, Pernille Thingstad, Bjørn Heine Strand, Geir Selbæk, Tone Natland Fagerhaug, Lene Thoresen
BACKGROUND: Malnutrition is common in older adults and is associated with increased morbidity and mortality rates. AIM: The aim of the study is to describe the prevalence of malnutrition based on low BMI, involuntary weight loss, and reduced food intake, in a Norwegian population of community-dwelling older adults and older adults living in nursing homes. METHODS: This population-based study is part of the fourth wave of the Trøndelag Health Study (HUNT4) and includes participants ≥70 years from the HUNT4 70+ cohort...
October 2023: Clinical Nutrition ESPEN
https://read.qxmd.com/read/37653047/ilio-femoral-venous-stenting-for-post-thrombotic-syndrome-in-women-of-childbearing-age-efficacy-and-impact-of-pregnancy-a-multi-center-study-by-the-french-society-of-cardiovascular-imaging
#9
JOURNAL ARTICLE
Clément Marcelin, Francine Thouveny, Gilles Goyault, Costantino Del Giudice, Romaric Loffroy, Marc Sapoval, Frederic Douane, Mathieu Rodiere, Amandine Crombé, Yann Le Bras
OBJECTIVE: We investigated the efficacy of iliofemoral venous stenting in women of childbearing age treated for post-thrombotic syndrome (PTS) and assessed the influence of pregnancy on stent occlusion. METHODS: A retrospective analysis was conducted on women of childbearing age who underwent endovascular stenting for PTS due to chronic iliocava occlusion across 15 centers from 2009 to 2020. The study assessed pregnancy rates, primary patency rates, secondary patency rates, and clinical efficacy using the Villalta score for PTS severity and the Chronic Venous Disease Quality of Life Questionnaire - version 20 (CIVIQ-20), 6-12 months after the procedure...
August 31, 2023: European Radiology
https://read.qxmd.com/read/37624410/accuracy-of-radiographic-projections-to-guide-cephalic-screw-position-in-pertrochanteric-fracture-a-cadaveric-study
#10
JOURNAL ARTICLE
Francesco Lazzarini, Tommaso Paoli, Andrea Cozzi Lepri, Gregorio Secci, Luigi Zanna, Matteo Innocenti, Fabrizio Matassi, Christian Carulli, Roberto Civinini
PURPOSE: The aim of this study was to evaluate the relationship between the Löwenstein Lateral view and the True Lateral view for the positioning of the cephalic hip screw, through a cadaveric study. MATERIALS AND METHODS: We placed two Kirschner wires in eight femur specimens using an Antero-Posterior view, Löwenstein Lateral view and True Lateral view. The distances between the Kirschner wires and the anterior, posterior, superior and inferior cortex were measured in all projections...
August 25, 2023: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://read.qxmd.com/read/37500072/use-of-endoscopic-submucosal-dissection-or-full-thickness-resection-device-to-treat-residual-colorectal-neoplasia-after-endoscopic-resection-a-multicenter-historical-cohort-study
#11
Clara Yzet, Yann Le Baleur, Jérémie Albouys, Jérémie Jacques, Paul Doumbe-Mandengue, Maximilien Barret, Einas Abou Ali, Marion Schaefer, Jean-Baptiste Chevaux, Sarah Leblanc, Vincent Lepillez, Jocelyn Privat, Thibault Degand, Timothée Wallenhorst, Jérôme Rivory, Ulriikka Chaput, Arthur Berger, Karim Aziz, Gabriel Rahmi, Emmanuel Coron, Eric Kull, Ludovic Caillo, Geoffroy Vanbiervliet, Stéphane Koch, Fabien Subtil, Mathieu Pioche
INTRODUCTION : Residual colorectal neoplasia (RCN) after previous endoscopic mucosal resection is a frequent challenge. Different management techniques are feasible including endoscopic full-thickness resection using the full-thickness resection device (FTRD) system and endoscopic submucosal dissection (ESD). We aimed to compare the efficacy and safety of these two techniques for the treatment of such lesions. METHODS : All consecutive patients with RCN treated either using the FTRD or by ESD were retrospectively included in this multicenter study...
July 27, 2023: Endoscopy
https://read.qxmd.com/read/37285124/review-finds-benefits-of-primary-care-continuity
#12
JOURNAL ARTICLE
Emily Harris
No abstract text is available yet for this article.
June 7, 2023: JAMA
https://read.qxmd.com/read/37266863/development-of-a-multiplex-panel-with-36-insertion-deletion-markers-indel-for-individual-identification
#13
JOURNAL ARTICLE
Gonul Filoglu, Arzu Duvenci, Sebahat Tas, Huseyin Karadayi, Faruk Asicioglu, Ozlem Bulbul
In recent years, the insertion/deletion (InDel) polymorphism has become a preferred genetic marker in forensic genetics due to its low mutation rates and small amplicon sizes. In this study, a 36-InDelplex identification panel, consisting of autosomal 34 InDel loci, 1 Y InDel locus, and amelogenin, was developed, and gene frequencies in the Turkish population were determined. The loci of the InDel panel with global minimum allele frequencies (MAF) ≥ 0.4 were selected from the 1000 Genomes Project Phase 3 data...
June 2, 2023: Forensic Science, Medicine, and Pathology
https://read.qxmd.com/read/37217123/short-term-effects-of-tropospheric-ozone-and-other-environmental-factors-on-emergency-admissions-due-to-pregnancy-complications-a-time-series-analysis-in-the-madrid-region
#14
JOURNAL ARTICLE
A Calle-Martínez, R Ruiz-Páez, L Gómez-González, A Egea-Ferrer, J A López-Bueno, J Díaz, C Asensio, M A Navas, C Linares
Air pollution has been linked to adverse neonatal outcomes, mainly in the case of prolonged exposures. This study focuses on the short-term effects on maternal health. We conducted a retrospective ecological time-series study in the Madrid Region covering the period 2013-2018. The independent variables were mean daily concentrations of tropospheric ozone (O3 ), particulate matter (PM10 /PM2.5 ) and nitrogen dioxide (NO2 ), as well as noise levels. The dependent variables were daily emergency hospital admissions due to complications in pregnancy, childbirth and the puerperium...
May 20, 2023: Environmental Research
https://read.qxmd.com/read/37099582/preventive-antibiotic-therapy-in-sinus-elevation-procedures-a-systematic-review
#15
JOURNAL ARTICLE
Ángel-Orión Salgado-Peralvo, Alvaro Garcia-Sanchez, Naresh Kewalramani, Mario Romandini, Eugenio Velasco-Ortega
Purpose: To study whether the use of preventive antibiotic therapy reduces the sinus graft infection and/or dental implant failure rates in maxillary sinus elevation surgeries (primary outcome), and to identify the associated best protocol (secondary outcome). Materials and Methods: The MEDLINE (via PubMed), Web of Science, Scopus, LILACS, and OpenGrey databases were searched between December 2006 and December 2021. Prospective and retrospective comparative clinical studies with at least 50 patients and published in English were included...
2023: International Journal of Oral & Maxillofacial Implants
https://read.qxmd.com/read/37044115/incarceration-of-the-gravid-uterus-a-rare-condition-not-to-be-missed
#16
JOURNAL ARTICLE
Nadja Grosse, Sandy Liem, Elvira Miller, Gunnar Möller, Jürgen Weidemann, Christine A Morfeld, Ralf Schild, Katrin Oehler-Rahman
BACKGROUND: Incarceration of a gravid uterus (IGU) is a rare manifestation in obstetrics that may be associated with serious complications. CASE: We report on a 29-year-old patient at 34+2 weeks' gestation who presented with HELLP syndrome. IGU had been initially diagnosed in our department at 23+6 weeks' gestation. Urgent cesarean section was performed taking into account the specific characteristics of IGU. A healthy premature child was born. With the prior knowledge of IGU no complications during delivery occurred and mother and child had favorable outcomes...
April 12, 2023: Zeitschrift Für Geburtshilfe und Neonatologie
https://read.qxmd.com/read/37006478/mri-based-radiomics-models-for-the-early-prediction-of-radiation-induced-temporal-lobe-injury-in-nasopharyngeal-carcinoma
#17
JOURNAL ARTICLE
Lixuan Huang, Zongxiang Yang, Zisan Zeng, Hao Ren, Muliang Jiang, Yao Hu, Yifan Xu, Huiting Zhang, Kun Ma, Liling Long
OBJECTIVE: This study was conducted to develop and validate a radiomics-clinics combined model-based magnetic resonance imaging (MRI) radiomics and clinical features for the early prediction of radiation-induced temporal lobe injury (RTLI) in patients with nasopharyngeal carcinoma (NPC). METHODS: This retrospective study was conducted using data from 130 patients with NPC (80 patients with and 50 patients without RTLI) who received radiotherapy. Cases were assigned randomly to training ( n = 91) and testing ( n = 39) datasets...
2023: Frontiers in Neurology
https://read.qxmd.com/read/36969927/sharing-is-living-the-role-of-habitat-heterogeneity-in-the-coexistence-of-closely-related-species
#18
JOURNAL ARTICLE
Fábio H C Sanches, Fernando R De Grande, Tânia M Costa, Rodrigo E Barreto
In biologically diverse ecosystems, an essential process to support competing species to coexist is ecological differentiation. Habitat heterogeneity is, hence, important in establishing species abundance and richness, favoring the coexistence of species due to habitat partition. In this context, shading and species thermal tolerance can be good factors to elucidate the role of habitat heterogeneity in the habitat partition among closely related species. Herein, we study shading effects in microhabitat selection, behavior, and physiological limitation on two species of fiddler crabs ( Leptuca leptodactyla and Leptuca uruguayensis )...
March 2023: Ecology and Evolution
https://read.qxmd.com/read/36931538/de-interact-a-machine-learning-based-predictive-tool-for-the-drug-excipient-interaction-study-during-product-development-validation-through-paracetamol-and-vanillin-as-a-case-study
#19
JOURNAL ARTICLE
Swayamprakash Patel, Mehul Patel, Mangesh Kulkarni, Mruduka S Patel
The compatibility of drugs with excipients plays a crucial role in the prospective stability of pharmaceutical formulations. Apart from real-time stability studies, conventional analytical tools like DSC, FTIR, NMR, and chromatography help identify the possibilities of drug-excipient interactions. Machine learning can assist in developing a predictive tool for drug-excipient incompatibility. In the present work, PubChem Fingerprint is employed as the descriptor of compounds that thoroughly represents the drug's and excipient's chemistry...
March 15, 2023: International Journal of Pharmaceutics
https://read.qxmd.com/read/36850189/selective-adsorption-of-quercetin-by-the-sol-gel-surface-molecularly-imprinted-polymer
#20
JOURNAL ARTICLE
Keke Zhi, Zhe Li, Han Luo, Yitong Ding, Feiyan Chen, Yongxiang Tan, Hongrui Liu
Quercetin, as one of the most biologically active natural flavonoids, is widely found in various vegetables, fruits and Chinese herbs. In this work, molecularly imprinted polymer (MIP) was synthesized through surface molecular imprinting technology with sol-gel polymerization mechanism on SiO2 at room temperature using quercetin as the template, SiO2 as the supporter, 3-aminopropyltriethoxysilane (APTES) as the functional monomer, and tetraethoxysilane (TEOS) as the cross-linker. The prepared MIP was characterized via scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR) and nitrogen adsorption measurements to validate its surface morphology, structure and functionality...
February 11, 2023: Polymers
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