Zhoulei Li, Zhihui Chen, Ruonan Zhang, Jinjiang Lin, Siyun Huang, Kuangyu Shi, Xiaodi Shen, Zijun Xiang, Xinyue Wang, Lili Huang, Qingzhu Zheng, Xubin Liu, Jinyu Tan, Minhu Chen, Ziping Li, Ren Mao, Xiangsong Zhang, Yangdi Wang, Xinming Song, Xuehua Li
PURPOSE: Accurately and early detection of intestinal fibrosis in Crohn's disease (CD) is crucial for clinical management yet remains an unmet need. Fibroblast activation protein inhibitor (FAPI) PET/CT has emerged as a promising tool to assess fibrosis. We aimed to investigate the diagnostic capability of [18 F]F-FAPI PET/CT in detecting intestinal fibrosis and compared it with[18 F]F-FDG PET/CT and magnetization transfer MR imaging (MTI). METHODS: Twenty-two rats underwent TNBS treatment to simulate fibrosis development, followed by three quantitative imaging sessions within one week...
February 15, 2024: European Journal of Nuclear Medicine and Molecular Imaging