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https://www.readbyqxmd.com/read/28812002/image-guided-thermal-ablation-with-mr-based-thermometry
#1
REVIEW
Mingming Zhu, Ziqi Sun, Chin K Ng
Thermal ablation techniques such as radiofrequency, microwave, high intensity focused ultrasound (HIFU) and laser have been used as minimally invasive strategies for the treatment of variety of cancers. MR thermometry methods are readily available for monitoring thermal distribution and deposition in real time, leading to decrease of incidents of normal tissue damage around targeted lesion. HIFU and laser-induced thermal therapy (LITT) are the two widely accepted tumor ablation techniques because of their compatibility with MR systems...
June 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28799280/amide-proton-transfer-weighted-imaging-to-differentiate-malignant-from-benign-pulmonary-lesions-comparison-with-diffusion-weighted-imaging-and-fdg-pet-ct
#2
Yoshiharu Ohno, Yuji Kishida, Shinichiro Seki, Masao Yui, Mitsue Miyazaki, Hisanobu Koyama, Takeshi Yoshikawa
PURPOSE: To compare the capability of amide proton transfer-weighted (APTw) imaging, diffusion-weighted imaging (DWI), and FDG-PET/CT for the differentiation of malignant from benign pulmonary nodules. MATERIALS AND METHODS: In all, 82 consecutive patients with pulmonary nodules underwent APTw imaging and DWI with a 3T system, and FDG-PET/CT. All nodules were divided as either malignant (n = 49) or benign (n = 39) groups based on pathological and follow-up examinations...
August 11, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28792646/clinical-applications-of-chemical-exchange-saturation-transfer-cest-mri
#3
Kyle M Jones, Alyssa C Pollard, Mark D Pagel
Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) has been developed and employed in multiple clinical imaging research centers worldwide. Selective radiofrequency (RF) saturation pulses with standard 2D and 3D MRI acquisition schemes are now routinely performed, and CEST MRI can produce semiquantitative results using magnetization transfer ratio asymmetry (MTRasym ) analysis while accounting for B0 inhomogeneity. Faster clinical CEST MRI acquisition methods and more quantitative acquisition and analysis routines are under development...
August 9, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28780188/ultrashort-echo-time-t2-%C3%A2-values-decrease-in-tendons-with-application-of-static-tensile-loads
#4
Saeed Jerban, Amin Nazaran, Xin Cheng, Michael Carl, Nikolaus Szeverenyi, Jiang Du, Eric Y Chang
In early stages of tendon disease, mechanical properties may become altered prior to changes in morphological anatomy. Ultrashort echo time (UTE) magnetic resonance imaging (MRI) can be used to directly detect signal from tissues with very short T2 values, including unique viscoelastic tissues such as tendons. The purpose of this study was to use UTE sequences to measure T2(∗), T1 and magnetization transfer ratio (MTR) variations of tendon samples under static tensile loads. Six human peroneal tendons were imaged before and under static loading using UTE sequences on a clinical 3T MRI scanner...
July 25, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28776754/quantitative-two-dimensional-ultrashort-echo-time-magnetization-transfer-2d-ute-mt-imaging-of-cortical-bone
#5
Ya-Jun Ma, Anthony Tadros, Jiang Du, Eric Y Chang
PURPOSE: To investigate quantitative 2D ultrashort echo time magnetization transfer (UTE-MT) imaging in ex vivo bovine cortical bone and in vivo human tibial cortical bone. METHODS: Data were acquired from five fresh bovine cortical bone samples and five healthy volunteer tibial cortical bones using a 2D UTE-MT sequence on a clinical 3T scanner. The 2D UTE-MT sequence used four or five MT powers with five frequency offsets. Results were analyzed with a two-pool quantitative MT model, providing measurements of macromolecular fraction (f), macromolecular proton transverse relaxation times (T2m ), proton exchange rates from water/macromolecular to the macromolecular/water pool (RM0m /RM0w ), and spin-lattice relaxation rate of water pool (R1w )...
August 3, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28774580/advancing-imaging-technologies-for-patients-with-spinal-pain-with-a-focus-on-whiplash-injury
#6
James M Elliott, Mark J Hancock, Rebecca J Crawford, Andrew C Smith, David M Walton
BACKGROUND CONTEXT: Radiological observations of soft-tissue changes that may relate to clinical symptoms in patients with traumatic and non-traumatic spinal disorders are highly controversial. Studies are often of poor quality and findings inconsistent. A plethora of evidence suggests some pathoanatomical findings from traditional imaging applications are common in asymptomatic participants across the life span, which further questions the diagnostic, prognostic, and theranostic value of traditional imaging...
July 31, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28761809/evaluating-single-point-quantitative-magnetization-transfer-in-the-cervical-spinal-cord-application-to-multiple-sclerosis
#7
Alex K Smith, Samantha By, Bailey D Lyttle, Richard D Dortch, Bailey A Box, Lydia J Mckeithan, Saakshi Thukral, Francesca Bagnato, Siddharama Pawate, Seth A Smith
Spinal cord (SC) damage is linked to clinical deficits in patients with multiple sclerosis (MS), however, conventional MRI methods are not specific to the underlying macromolecular tissue changes that may precede overt lesion detection. Single-point quantitative magnetization transfer (qMT) is a method that can provide high-resolution indices sensitive to underlying macromolecular composition in a clinically feasible scan time by reducing the number of MT-weighted acquisitions and utilizing a two-pool model constrained by empirically determined constants...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28750205/corrigendum-to-the-physical-mechanism-of-inhomogeneous-magnetization-transfer-mri-j-magn-reson-274-2017-125-136
#8
Alan P Manning, Kimberley L Chang, Alex L MacKay, Carl A Michal
No abstract text is available yet for this article.
July 24, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28743460/high-resolution-in-vivo-imaging-of-human-locus-coeruleus-by-magnetization-transfer-mri-at-3t-and-7t
#9
Nikos Priovoulos, Heidi I L Jacobs, Dimo Ivanov, Kamil Uludag, Frans R J Verhey, Benedikt A Poser
Locus Coeruleus (LC) is a neuromelanin-rich brainstem structure that is the source of noradrenaline in the cortex and is thought to modulate attention and memory. LC imaging in vivo is commonly performed with a 2D T1-weighted Turbo Spin Echo (TSE) MRI sequence, an approach that suffers from several drawbacks at 3T, including long acquisition times and highly anisotropic spatial resolution. In this study, we developed a high-resolution Magnetization Transfer (MT) sequence for LC imaging at both 7T and 3T and compared its performance to a TSE sequence...
July 22, 2017: NeuroImage
https://www.readbyqxmd.com/read/28736875/assessment-of-unilateral-ureter-obstruction-with-multi-parametric-mri
#10
Feng Wang, Keiko Takahashi, Hua Li, Zhongliang Zu, Ke Li, Junzhong Xu, Raymond C Harris, Takamune Takahashi, John C Gore
PURPOSE: Quantitative multi-parametric MRI (mpMRI) methods may allow the assessment of renal injury and function in a sensitive and objective manner. This study aimed to evaluate an array of MRI methods that exploit endogenous contrasts including relaxation rates, pool size ratio (PSR) derived from quantitative magnetization transfer (qMT), chemical exchange saturation transfer (CEST), nuclear Overhauser enhancement (NOE), and apparent diffusion coefficient (ADC) for their sensitivity and specificity in detecting abnormal features associated with kidney disease in a murine model of unilateral ureter obstruction (UUO)...
July 24, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28733991/ph-sensitive-amide-proton-transfer-effect-dominates-the-magnetization-transfer-asymmetry-contrast-during-acute-ischemia-quantification-of-multipool-contribution-to-in-vivo-cest-mri
#11
Yin Wu, Iris Yuwen Zhou, Dongshuang Lu, Emiri Manderville, Eng H Lo, Hairong Zheng, Phillip Zhe Sun
PURPOSE: To determine the origins of in vivo magnetization transfer asymmetry contrast during acute ischemic stroke, particularly in the diffusion lesion, perfusion lesion, and their mismatch using a middle cerebral artery occlusion rat model of acute stroke. METHODS: Adult male Wistar rats underwent multiparametric MRI of diffusion, perfusion, T1 , and amide proton transfer (APT) imaging at 4.7 T following a middle cerebral artery occlusion procedure. A multipool Lorentzian model, including the nuclear Overhauser effect, magnetization transfer, direct water saturation, amine and amide chemical exchange saturation transfer effects, was applied for Z-spectrum fitting to determine the sources of in vivo magnetization transfer asymmetry following acute stroke...
July 21, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28729292/amide-proton-transfer-imaging-allows-detection-of-glioma-grades-and-tumor-proliferation-comparison-with-ki-67-expression-and-proton-mr-spectroscopy-imaging
#12
C Su, C Liu, L Zhao, J Jiang, J Zhang, S Li, W Zhu, J Wang
BACKGROUND AND PURPOSE: Prognosis in glioma depends strongly on tumor grade and proliferation. In this prospective study of patients with untreated primary cerebral gliomas, we investigated whether amide proton transfer-weighted imaging could reveal tumor proliferation and reliably distinguish low-grade from high-grade gliomas compared with Ki-67 expression and proton MR spectroscopy imaging. MATERIALS AND METHODS: This study included 42 patients with low-grade (n = 28) or high-grade (n = 14) glioma, all of whom underwent conventional MR imaging, proton MR spectroscopy imaging, and amide proton transfer-weighted imaging on the same 3T scanner within 2 weeks before surgery...
July 20, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28727209/a-dual-flip-angle-3d-bssfp-magnetization-transfer-like-method-to-differentiate-between-recent-and-old-myocardial-infarction
#13
Philippe Germain, Soraya El Ghannudi, Aissam Labani, Mi Y Jeung, Afshin Gangi, Patrick Ohlmann, Catherine Roy
BACKGROUND: Magnetic resonance imaging (MRI) tissue signal is modulated by magnetization transfer (MT) phenomena, intrinsically induced by balanced steady-state free precession (bSSFP) imaging. PURPOSE: To investigate the possible value of such a MT-like bSSFP approach in two clinical settings involving focal myocardial lesions highligthed by late gadolinium enhancement (LGE+): edema induced by recent myocardial infarction (MI) and fibrotic scar related to chronic infarction...
July 20, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28723279/magnetization-transfer-imaging-in-treatment-resistant-depression-structural-evidence-of-a-functional-derangement-that-might-help-guide-therapy
#14
Karen Buch, Bernardo Bizzo, Michael H Lev
No abstract text is available yet for this article.
August 2017: Radiology
https://www.readbyqxmd.com/read/28695472/assessing-repair-in-multiple-sclerosis-outcomes-for-phase-ii-clinical-trials
#15
REVIEW
Maria Pia Sormani, Matteo Pardini
Multiple Sclerosis (MS) pathology is complex and includes inflammatory processes, neurodegeneration, and demyelination. While multiple drugs have been developed to tackle MS-related inflammation, to date there is scant evidence regarding which therapeutic approach, if any, could be used to reverse demyelination, foster tissue repair, and thus positively impact on chronic disability. Here, we reviewed the current structural and functional markers (magnetic resonance imaging, positron emission tomography, optical coherence tomography, and visual evoked potentials) which could be used in phase II clinical trials of new compounds aimed to foster tissue repair in MS...
July 10, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/28674916/-2-h-13-c-correlation-solid-state-nmr-for-investigating-dynamics-and-water-accessibilities-of-proteins-and-carbohydrates
#16
Martin D Gelenter, Tuo Wang, Shu-Yu Liao, Hugh O'Neill, Mei Hong
Site-specific determination of molecular motion and water accessibility by indirect detection of (2)H NMR spectra has advantages over dipolar-coupling based techniques due to the large quadrupolar couplings and the ensuing high angular resolution. Recently, a Rotor Echo Short Pulse IRrAdiaTION mediated cross polarization ((RESPIRATION)CP) technique was developed, which allowed efficient transfer of (2)H magnetization to (13)C at moderate (2)H radiofrequency field strengths available on most commercial MAS probes...
July 3, 2017: Journal of Biomolecular NMR
https://www.readbyqxmd.com/read/28661067/medial-prefrontal-cortex-deficits-correlate-with-unrefreshing-sleep-in-patients-with-chronic-fatigue-syndrome
#17
Zack Y Shan, Richard Kwiatek, Richard Burnet, Peter Del Fante, Donald R Staines, Sonya M Marshall-Gradisnik, Leighton R Barnden
Unrefreshing sleep is a hallmark of chronic fatigue syndrome/myalgic encephalomyelitis (CFS). This study examined brain structure variations associated with sleep quality in patients with CFS. 38 patients with CFS (34.8 ± 10.1 years old) and 14 normal controls (NCs) (34.7 ± 8.4 years old) were recruited. All subjects completed the Hospital Anxiety and Depression Scale, Pittsburgh Sleep Quality Index (PSQI), and Chalder Fatigue Scale (CFQ) questionnaires. Brain MRI measures included global and regional grey and white matter volumes, magnetization transfer T1 weighted (MT-T1w) intensities, and T1 weighted (T1w) and T2 weighted spin echo signal intensities...
June 29, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28660330/quantitative-mri-of-kidneys-in-renal-disease
#18
Timothy L Kline, Marie E Edwards, Ishan Garg, Maria V Irazabal, Panagiotis Korfiatis, Peter C Harris, Bernard F King, Vicente E Torres, Sudhakar K Venkatesh, Bradley J Erickson
PURPOSE: To evaluate the reproducibility and utility of quantitative magnetic resonance imaging (MRI) sequences for the assessment of kidneys in young adults with normal renal function (eGFR ranged from 90 to 130 mL/min/1.73 m(2)) and patients with early renal disease (autosomal dominant polycystic kidney disease). MATERIALS AND METHODS: This prospective case-control study was performed on ten normal young adults (18-30 years old) and ten age- and sex-matched patients with early renal parenchymal disease (autosomal dominant polycystic kidney disease)...
June 28, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28639301/improving-the-detection-sensitivity-of-ph-weighted-amide-proton-transfer-mri-in-acute-stroke-patients-using-extrapolated-semisolid-magnetization-transfer-reference-signals
#19
Hye-Young Heo, Yi Zhang, Tina M Burton, Shanshan Jiang, Yansong Zhao, Peter C M van Zijl, Richard Leigh, Jinyuan Zhou
PURPOSE: To quantify amide protein transfer (APT) effects in acidic ischemic lesions and assess the spatial-temporal relationship among diffusion, perfusion, and pH deficits in acute stroke patients. METHODS: Thirty acute stroke patients were scanned at 3 T. Quantitative APT (APT(#) ) effects in acidic ischemic lesions were measured using an extrapolated semisolid magnetization transfer reference signal technique and compared with commonly used MTRasym (3.5ppm) or APT-weighted parameters...
September 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28601503/cortical-magnetization-transfer-abnormalities-and-connectome-dysconnectivity-in-schizophrenia
#20
Yongbin Wei, Guusje Collin, René C W Mandl, Wiepke Cahn, Kristin Keunen, Ruben Schmidt, René S Kahn, Martijn P van den Heuvel
Macroscale dysconnectivity in schizophrenia is associated with neuropathological abnormalities. The extent to which alterations in cortical myelination as revealed in vivo by magnetization transfer ratio (MTR) are related to macroscale dysconnectivity remains unknown. We acquired magnetization transfer imaging (MTI) data and diffusion weighted imaging (DWI) data from 78 schizophrenia patients and 93 healthy controls for MTR extraction and connectome reconstruction to examine the possible link between cortical myelination and macroscale dysconnectivity...
June 7, 2017: Schizophrenia Research
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