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Microcytic anemia

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https://www.readbyqxmd.com/read/29782390/suspecting-hyperferritinemic-sepsis-in-iron-deficient-population-do-we-need-a-lower-plasma-ferritin-threshold
#1
Swarup Ghosh, Arun K Baranwal, Prateek Bhatia, Karthi Nallasamy
OBJECTIVES: Hyperferritinemia is being suggested to identify patients with sepsis-induced macrophage activation syndrome for early intervention. However, data among iron-deficient children are scarce. This study was planned to explore the biological behavior of plasma ferritin in children from communities with a high frequency of iron deficiency with septic shock and its association with the outcome. DESIGN: Prospective observational study. SETTING: Tertiary care teaching hospital in a low-middle income economy of South Asia...
May 18, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29746238/methods-for-studying-iron-regulatory-protein-1-an-important-protein-in-human-iron-metabolism
#2
Gregory P Holmes-Hampton, Manik C Ghosh, Tracey A Rouault
Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are two cytosolic proteins that maintain cellular iron homeostasis by regulating the expression of genes involved in iron metabolism. IRPs respond to cellular iron deficiency by binding to iron-responsive elements (IREs) found in the mRNAs of iron metabolism transcripts, enhancing iron import, and reducing iron storage, utilization, and export. IRP1, a bifunctional protein, exists in equilibrium between a [Fe4 S4 ] cluster containing cytosolic aconitase, and an apoprotein that binds to IREs...
2018: Methods in Enzymology
https://www.readbyqxmd.com/read/29743399/-successful-treatment-of-x-linked-sideroblastic-anemia-with-alas2-r452h-mutation-using-vitamin-b-6
#3
Toru Kawakami, Hideyuki Nakazawa, Fumihiro Kawakami, Shuji Matsuzawa, Yuriko Sudo, Hitoshi Sakai, Sayaka Nishina, Noriko Senoo, Yasushi Senoo, Michiharu Komatsu, Takeji Umemura, Tomomi Yamaguchi, Tomoki Kosho, Tohru Fujiwara, Hideo Harigae, Fumihiro Ishida
A 45-year-old man presented with fatigue and pain in the finger joints. Despite having a history of suspected sideroblastic anemia since the age of 18 years, he had not been followed up for years. Upon presentation, laboratory data revealed microcytic anemia and elevated serum ferritin levels. In addition, ringed sideroblasts were increased in the bone marrow. A liver biopsy revealed hemochromatosis and cirrhosis. Furthermore, genetic analysis revealed that he harbored the ALAS2 R452H mutation, leading to the diagnosis of X-linked sideroblastic anemia (XLSA)...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/29732485/role-of-melatonin-in-aluminum-related-neurodegenerative-disorders-a-review
#4
José L Esparza, Mercedes Gómez, José L Domingo
Aluminum (Al), a potentially neurotoxic element, provokes various adverse effects on human health such as dialysis dementia, osteomalacia, and microcytic anemia. It has been also associated with serious neurodegenerative diseases such as Alzheimer's disease (AD), amyotrophic lateral sclerosis, and Parkinsonism dementia of Guam. The "aluminum hypothesis" of AD assumes that the metal complexes can potentiate the rate of aggregation of amyloid-β (Aβ), enhancing the toxicity of this peptide, and being able of contributing to the pathogenesis of AD...
May 7, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29696692/the-impact-of-erythropoietin-and-iron-status-on-brain-myelination-in-the-newborn-rat
#5
Karen P Flores, Sharon E Blohowiak, Joy J Winzerling, Michael K Georgieff, Pamela J Kling
Erythropoietin (Epo) drives iron (Fe) utilization for erythropoiesis, but the potentially resultant tissue iron deficiency (ID) can also impede brain development. Conversely, Epo binds to Epo receptors (EpoR) on immature brain oligodendrocytes and neurons, promoting growth and differentiation. The objective of the study was to examine the interaction between Epo and Fe on myelination in brain development during daily Epo treatment. Male and female Sprague-Dawley rats from postnatal day (P) P4-P12 modeled premature newborns...
April 26, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/29668548/clinical-course-of-homozygous-hemoglobin-constant-spring-in-pediatric-patients
#6
Patcharee Komvilaisak, Arunee Jetsrisuparb, Goonnapa Fucharoen, Ratana Komwilaisak, Junya Jirapradittha, Pakaphan Kiatchoosakun
BACKGROUND: Hemoglobin (Hb) Constant Spring is an alpha-globin gene variant due to a mutation of the stop codon resulting in the elongation of the encoded polypeptide from 141 to 172 amino acid residues. Patients with homozygous Hb Constant Spring are usually mildly anemic. METHODS: We retrospectively describe clinical manifestations, diagnosis, laboratory investigations, treatment, and associated findings in pediatric patients with homozygous Hb Constant Spring followed-up at Srinagarind Hospital...
April 17, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29609162/determining-mean-corpuscular-volume-and-red-blood-cell-count-using-electrochemical-collision-events
#7
Thy L T Ho, Nhung T T Hoang, Jungeun Lee, Jun Hui Park, Byung-Kwon Kim
Blood tests (e.g., red blood cell (RBC) count) are crucial for detecting, diagnosing, and monitoring the progression of blood disorders. Here, we report the development of a new and rapid method for electrochemically detecting RBCs using single-particle collision events. The principle of this method relies on the electrochemical oxidation of an electroactive redox species (potassium ferrocyanide) hindered by an RBC attached to an electrode surface. A decrease in staircase current, caused by the collision of RBCs on the electrode, was observed...
March 26, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29588085/microcytic-anemia-due-to-ileocolic-anastomotic-ulcer
#8
Jesús Manuel Rivera Esteban, Eloy Espín Basany, Javier Santos Vicente, Carmen Alonso-Cotoner
No abstract text is available yet for this article.
March 24, 2018: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/29587599/pathological-and-clinical-pathological-changes-induced-by-four-week-repeated-dose-oral-administration-of-the-wood-preservative-chromated-copper-arsenate-in-wistar-rats
#9
Naofumi Takahashi, Toshinori Yoshida, Sayuri Kojima, Satoru Yamaguchi, Ryoichi Ohtsuka, Makio Takeda, Tadashi Kosaka, Takanori Harada
Chromated copper arsenate (CCA) is used as a wood preservative worldwide. Exposure to it may adversely affect human health. Some events have increased human exposure to CCA, including the Great East Japan Earthquake, which generated a large amount of lumber debris from CCA-treated woods. We elucidated the toxicity due to daily exposure to CCA over a 4-week period at doses of 0, 8, 40, and 80 mg/kg/day in Wistar Hannover rats. Chromium (Cr) and arsenic (As), but not copper, were detected in the plasma samples of rats treated with various doses of CCA...
January 1, 2018: Toxicologic Pathology
https://www.readbyqxmd.com/read/29582203/prevalence-and-types-of-anemia-in-a-large-refugee-cohort-in-western-europe-in-2015
#10
Alexandra Jablonka, Martin Wetzke, Georgios Sogkas, Christian Dopfer, Reinhold Ernst Schmidt, Georg M N Behrens, Christine Happle
Currently, vast numbers of migrants with largely unknown health statuses have been entering Europe. To improve care taking strategies, prevalence, severity and types of anemia in a large refugee cohort were assessed. Blood counts were performed in n = 787 inhabitants from six German refugee centers. Most included migrants were young, male adults. Anemia was present in 22.5% of subjects with an age-dependent prevalence increase (7.9% > 18 years vs. 30.8% > 50 years). More females than males were anemic (27...
March 26, 2018: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/29563675/identification-of-iron-status-of-blood-donors-by-using-low-hemoglobin-density-and-microcytic-anemia-factor
#11
Ashutosh Singh, Rajendra Chaudhary, Hem C Pandey, Atul Sonker
BACKGROUND: Two new parameters low hemoglobin density (LHD) and microcytic anemia factor (Maf) have been used by Beckman-Coulter LH series analyzers as an easy screening tool for the early detection of iron deficiency. The main objective of this study was to assess if LHD and Maf could be used for assessment of iron status in blood donors and also to establish a cut-off for these two parameters at which a tentative iron deficiency could be reported conclusively. MATERIALS AND METHODS: LHD% and Maf could be calculated by knowing mean cell hemoglobin (Hb) concentration, Hb, and mean cellular volume and we used SPSS in calculating LHD and Maf from these parameters...
January 2018: Asian Journal of Transfusion Science
https://www.readbyqxmd.com/read/29503155/phenotypic-heterogeneity-in-seven-italian-cases-of-aceruloplasminemia
#12
Sara Pelucchi, Raffaella Mariani, Giulia Ravasi, Irene Pelloni, Massimo Marano, Lucio Tremolizzo, Massimo Alessio, Alberto Piperno
INTRODUCTION: Aceruloplasminemia is an ultra-rare hereditary disorder characterized by iron-restricted microcytic anemia and tissue iron overload associated with diabetes, retinal and progressive neurological degeneration. We describe genotypes and phenotypes at diagnosis, and disease evolution of seven Italian patients. METHODS: Anagraphical, biochemical, genetic, clinical and instrumental data were collected at diagnosis and during a long-term follow-up. Mutations, ferroxidase activity and Western Blot analysis of ceruloplasmin were performed according to standard protocols...
February 24, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29486517/glycogen-storage-disease-type-ia-adult-presentation-with-microcytic-anemia-and-liver-adenomas
#13
Wouter Moest, Wendy van der Deure, Ted Koster, Marcela Spee-Dropková, Linda Swart-Busscher, Robbert J de Haas, Terry G J Derks
No abstract text is available yet for this article.
February 27, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29432304/anemia-in-adolescents-and-young-adult-patients-with-congenital-heart-disease
#14
Juan L Rodríguez-Hernández, Fayna Rodríguez-González, Efrén Martínez-Quintana
INTRODUCTION: Despite anemia in acquired heart disease being a common problem, little is known in patients with congenital heart disease (CHD). METHODS: In total, 544 consecutive stable noncyanotic CHD patients were studied to determine demographic, clinical, and analytic parameters. Anemia was defined as a condition in which hemoglobin concentration was <13 g/dL in male individuals and <12 g/dL in female individuals. RESULTS: In total, 49 (9%) CHD patients had anemia...
February 9, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29372060/pregnant-mothers-are-more-anemic-than-lactating-mothers-a-comparative-cross-sectional-study-bahir-dar-ethiopia
#15
Berhanu Elfu Feleke, Teferi Elfu Feleke
Background: Information on the hemoglobin status of pregnant and lactating mothers was scarce. The objectives of this study were to determine the burden and determinants of anemia in the pregnant and lactating mother. Methods: A comparative cross-sectional study was conducted. Descriptive statistics were used to identify the prevalence of anemia. Binary logistic regression and multiple linear regressions were used to identify the predictors of anemia. Results: The prevalence of anemia in lactating and pregnant women was 43...
2018: BMC Hematology
https://www.readbyqxmd.com/read/29365192/stability-of-new-erythrocyte-and-reticulocyte-parameters-in-testing-for-anemia-on-the-sysmex-xn-9000
#16
Elise Schapkaitz
Background: New erythrocyte and reticulocyte parameters provide improved classification of anemia and monitoring of erythropoeitic activity. Parameters available on the Sysmex XN analyzers include the percentage of microcytic red blood cells (%Micro-R), percentage of macrocytic red blood cells (%Macro-R), percentage of hypochromic red blood cells (%Hypo-He), percentage of hyperchromic red blood cells (%Hyper-He), reticulocyte hemoglobin content (Ret-He), and immature reticulocyte fraction (IRF)...
January 22, 2018: Laboratory Medicine
https://www.readbyqxmd.com/read/29348549/preoperative-anemia-in-colorectal-cancer-relationships-with-tumor-characteristics-systemic-inflammation-and-survival
#17
Juha P Väyrynen, Anne Tuomisto, Sara A Väyrynen, Kai Klintrup, Toni Karhu, Jyrki Mäkelä, Karl-Heinz Herzig, Tuomo J Karttunen, Markus J Mäkinen
Anemia is common in colorectal cancer (CRC) but its relationships with tumor characteristics, systemic inflammation, and survival have not been well characterized. In this study, blood hemoglobin levels and erythrocyte mean corpuscular volume (MCV) levels were measured in two independent cohorts of 148 CRC patients and 208 CRC patients, and their correlation with patient and tumor characteristics, systemic inflammatory markers (modified Glasgow Prognostic Score: mGPS; serum levels of thirteen cytokines, C-reactive protein, albumin), and survival were analyzed...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29174672/-aluminic-intoxication-in-chronic-hemodialysis-a-diagnosis-rarely-evoked-nowadays-clinical-case-and-review-of-the-literature
#18
Alexandre Seidowsky, Emmanuel Dupuis, Tilman Drueke, Serge Dard, Ziad A Massy, Bernard Canaud
Aluminum intoxication in chronic hemodialysis patients has virtually vanished over the last decade. Therefore, the diagnosis is rarely advocated at present. Aluminum intoxication in dialysis patients associates to different degrees with dialysis encephalopathy, bone disorders and microcytic anemia. We report here the observation of a patient receiving intermittent hemodialysis therapy who presented with acute encephalopathy. It turned out to be caused by aluminum intoxication secondary to a defect in dialysis water treatment...
February 2018: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29146407/-hemogram-profile-and-interest-of-pre-donation-hemoglobin-measurement-in-blood-donors-in-the-northwest-region-of-morocco
#19
S Bakrim, A Ouarour, K Jaidann, M Benajiba, A Masrar
BACKGROUND: Blood donation in Morocco and more particularly in the northwest region is carried out without prior determination of the pre-donation hemoglobin. In addition, we note the lack of scientific research that reports data on the red blood cells, leukocytes and platelet lines in donated blood at the regional or even national level. AIMS: To study hemogram profile in blood donors taken from the Northwest region of Morocco in order to provide decision makers of the National Center of Blood Transfusion and Hematology with valid scientific arguments to complete the criteria to donate whole blood, by the hemogram...
February 2018: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/29133274/gender-differences-in-the-impact-of-anemia-on-subclinical-myocardial-damage-and-cardiovascular-mortality-in-the-general-population-the-yamagata-takahata-study
#20
Yuki Honda, Tetsu Watanabe, Yoichiro Otaki, Harutoshi Tamura, Satoshi Nishiyama, Hiroki Takahashi, Takanori Arimoto, Tetsuro Shishido, Takuya Miyamoto, Yoko Shibata, Tsuneo Konta, Ryo Kawasaki, Makoto Daimon, Yoshiyuki Ueno, Takeo Kato, Takamasa Kayama, Isao Kubota
BACKGROUND: Anemia has been shown to worsen cardiovascular diseases. However, it is unclear whether there is a gender difference in the impact of anemia on subclinical myocardial damage and cardiovascular mortality in the general population. METHODS: A prospective cohort study was conducted in a community based on annual health checks. Serum heart-type fatty acid binding protein (H-FABP) levels, which is a marker for myocardial damage, and blood counts were measured at baseline in subjects without previous cardiovascular diseases (n=3111)...
February 1, 2018: International Journal of Cardiology
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