keyword
https://read.qxmd.com/read/38419081/thermomir-377-3p-induced-suppression-of-cirbp-expression-is-required-for-effective-elimination-of-cancer-cells-and-cancer-stem-like-cells-by-hyperthermia
#21
JOURNAL ARTICLE
Tao-Yan Lin, Jun-Shuang Jia, Wei-Ren Luo, Xiao-Lin Lin, Sheng-Jun Xiao, Jie Yang, Jia-Wei Xia, Chen Zhou, Zhi-Hao Zhou, Shu-Jun Lin, Qi-Wen Li, Zhi-Zhi Yang, Ye Lei, Wen-Qing Yang, Hong-Fen Shen, Shi-Hao Huang, Sheng-Chun Wang, Lin-Bei Chen, Yu-Lin Yang, Shu-Wen Xue, Yong-Long Li, Guan-Qi Dai, Ying Zhou, Ying-Chun Li, Fang Wei, Xiao-Xiang Rong, Xiao-Jun Luo, Bing-Xia Zhao, Wen-Hua Huang, Dong Xiao, Yan Sun
BACKGROUND: In recent years, the development of adjunctive therapeutic hyperthermia for cancer therapy has received considerable attention. However, the mechanisms underlying hyperthermia resistance are still poorly understood. In this study, we investigated the roles of cold‑inducible RNA binding protein (Cirbp) in regulating hyperthermia resistance and underlying mechanisms in nasopharyngeal carcinoma (NPC). METHODS: CCK-8 assay, colony formation assay, tumor sphere formation assay, qRT-PCR, Western blot were employed to examine the effects of hyperthermia (HT), HT + oridonin(Ori) or HT + radiotherapy (RT) on the proliferation and stemness of NPC cells...
February 29, 2024: Journal of Experimental & Clinical Cancer Research: CR
https://read.qxmd.com/read/38417593/impacts-of-poverty-and-lifestyles-on-mortality-a-cohort-study-in-predominantly-low-income-americans
#22
JOURNAL ARTICLE
Lili Liu, Wanqing Wen, Martha J Shrubsole, Loren E Lipworth, Michael T Mumma, Brooke A Ackerly, Xiao-Ou Shu, William J Blot, Wei Zheng
INTRODUCTION: Low socioeconomic status has been linked to increased mortality. However, the impacts of poverty, alone or combined with health behaviors, on mortality and life expectancy have not been adequately investigated. METHODS: Data from the Southern Community Cohort Study was used, including nearly 86,000 participants recruited during 2002-2009 across 12 US southeastern states. Analysis was conducted from February 2022 to January 2023. RESULTS: During a median follow-up of 12...
February 26, 2024: American Journal of Preventive Medicine
https://read.qxmd.com/read/38416769/anthracyclines-induce-cardiotoxicity-through-a-shared-gene-expression-response-signature
#23
JOURNAL ARTICLE
E Renee Matthews, Omar D Johnson, Kandace J Horn, José A Gutiérrez, Simon R Powell, Michelle C Ward
TOP2 inhibitors (TOP2i) are effective drugs for breast cancer treatment. However, they can cause cardiotoxicity in some women. The most widely used TOP2i include anthracyclines (AC) Doxorubicin (DOX), Daunorubicin (DNR), Epirubicin (EPI), and the anthraquinone Mitoxantrone (MTX). It is unclear whether women would experience the same adverse effects from all drugs in this class, or if specific drugs would be preferable for certain individuals based on their cardiotoxicity risk profile. To investigate this, we studied the effects of treatment of DOX, DNR, EPI, MTX, and an unrelated monoclonal antibody Trastuzumab (TRZ) on iPSC-derived cardiomyocytes (iPSC-CMs) from six healthy females...
February 28, 2024: PLoS Genetics
https://read.qxmd.com/read/38410897/-public-access-defibrillation-programs-progetto-vita-current-legal-aspects-and-challenges-for-the-future
#24
JOURNAL ARTICLE
Luca Rossi, Serena Bricoli, Daniela Aschieri
Out-of-hospital cardiac arrest (OHCA) represents a significant healthcare issue that is often underestimated. OHCA predominantly affects the general population, with staggering numbers: 400 000 cases annually in Europe and 350 000 in the United States, contributing to 50% of cardiovascular-related deaths. The vast majority of OHCA cases begin with a shockable rhythm, making effective treatment possible through early defibrillation, even by non-medical personnel using automated external defibrillators (AEDs)...
March 2024: Giornale Italiano di Cardiologia
https://read.qxmd.com/read/38408416/longitudinal-patterns-of-use-of-stimulants-and-opioids-in-the-aids-linked-to-the-intravenous-experience-cohort-2005-2019
#25
JOURNAL ARTICLE
Jacqueline E Rudolph, Javier A Cepeda, Jacquie Astemborski, Gregory D Kirk, Shruti H Mehta, Danielle German, Becky L Genberg
BACKGROUND: Overdoses involving opioids and stimulants are on the rise, yet few studies have examined longitudinal trends in use of both substances. We sought to describe use and co-use of opioids and stimulants, 2005-2019, in the AIDS Linked to the Intravenous Experience (ALIVE) cohort - a community-based cohort of people with a history of injection drug use living in or near Baltimore, MD. METHODS: We included 2083 ALIVE participants, who had at least two visits during the study period...
February 25, 2024: International Journal on Drug Policy
https://read.qxmd.com/read/38375317/slow-and-steady-wins-the-race-fractionated-near-infrared-treatment-empowered-by-graphene-enhanced-3d-scaffolds-for-precision-oncology
#26
JOURNAL ARTICLE
Giordano Perini, Valentina Palmieri, Andrea Papait, Alberto Augello, Daniela Fioretti, Sandra Iurescia, Monica Rinaldi, Elsa Vertua, Antonietta Silini, Riccardo Torelli, Angela Carlino, Teresa Musarra, Maurizio Sanguinetti, Ornella Parolini, Marco De Spirito, Massimiliano Papi
Surgically addressing tumors poses a challenge, requiring a tailored, multidisciplinary approach for each patient based on the unique aspects of their case. Innovative therapeutic regimens combined to reliable reconstructive methods can contribute to an extended patient's life expectancy. This study presents a detailed comparative investigation of near-infrared therapy protocols, examining the impact of non-fractionated and fractionated irradiation regimens on cancer treatment. The therapy is based on the implantation of graphene oxide/poly(lactic-co-glycolic acid) three-dimensional printed scaffolds, exploring their versatile applications in oncology by the examination of pro-inflammatory cytokine secretion, immune response, and in vitro and in vivo tumor therapy...
April 2024: Materials today. Bio
https://read.qxmd.com/read/38370709/deep-mutational-scanning-reveals-functional-constraints-and-antigenic-variability-of-lassa-virus-glycoprotein-complex
#27
Caleb R Carr, Katharine H D Crawford, Michael Murphy, Jared G Galloway, Hugh K Haddox, Frederick A Matsen, Kristian G Andersen, Neil P King, Jesse D Bloom
Lassa virus is estimated to cause thousands of human deaths per year, primarily due to spillovers from its natural host, Mastomys rodents. Efforts to create vaccines and antibody therapeutics must account for the evolutionary variability of Lassa virus's glycoprotein complex (GPC), which mediates viral entry into cells and is the target of neutralizing antibodies. To map the evolutionary space accessible to GPC, we use pseudovirus deep mutational scanning to measure how nearly all GPC amino-acid mutations affect cell entry and antibody neutralization...
February 6, 2024: bioRxiv
https://read.qxmd.com/read/38364783/from-the-operating-table-to-global-science-how-a-near-death-experience-sparked-my-passion-for-life
#28
JOURNAL ARTICLE
Kevin Christopher Brown
Kevin Christopher Brown Jr. is a winner of the fourth annual Rising Black Scientists Awards for a scholar in the life and health sciences. We asked emerging Black scientists to tell us about their scientific vision and goals, experiences that sparked their interest in science, how they want to contribute to a more inclusive scientific community, and how these all fit together on their journey. This is his story.
February 15, 2024: Cell
https://read.qxmd.com/read/38356269/lived-experiences-among-critically-ill-and-near-death-survivors-relating-to-the-covid-19-infection-a-phenomenological-study
#29
JOURNAL ARTICLE
Wichitra Kusoom, Sununta Krongyuth
INTRODUCTION: The COVID-19 pandemic has resulted in severe illnesses worldwide. Around 655.5 million cases were having been confirmed, including 6.6 million deaths. The extreme cases experienced near death in the intensive care unit (ICU). This study explored the survivors' experience of being near death while critically ill with the infection. METHODOLOGY: A descriptive phenomenological study was employed. Data were collected through in-depth interviews with 14 participants from Northeastern Thailand...
February 14, 2024: Journal of Transcultural Nursing: Official Journal of the Transcultural Nursing Society
https://read.qxmd.com/read/38338183/nurse-who-had-mers-cov-complications-with-a-near-death-experience-during-pregnancy-a-narrative-analysis
#30
JOURNAL ARTICLE
Abbas Al Mutair, Zainab Ambani, Alexander Woodman, Chandni Saha, Hanan F Alharbi, Alya Elgamri
BACKGROUND: According to prevailing views in neuroscience, near-death experiences (NDE) occurring after severe head trauma, critical illness, or coma are often life-transforming experiences in which no awareness or sensory experience of any kind is possible. Although there are general patterns, each case is quite different from the other and requires accurate recording and reporting to potentially explain the phenomenon. AIM: This narrative study aimed to explore a pregnant woman's NDE due to complications from MERS-CoV...
January 24, 2024: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/38333514/how-mass-spectrometry-revolutionized-newborn-screening
#31
REVIEW
David S Millington
This article offers a personal account of a remarkable journey spanning over 30 years of applied mass spectrometry in a clinical setting. It begins with the author's inspiration from a clinician's story of rescuing a child from near death with a revolutionary therapeutic intervention. Motivated by this experience, the author delved into the field of chemistry and mass spectrometry to solve an analytical challenge. The breakthrough came with the development of the first front-line diagnostic test performed by MS/MS, which focused on analyzing acylcarnitines to detect and diagnose inherited disorders related to fatty acid and branched-chain amino acid catabolism...
April 2024: Journal of mass spectrometry and advances in the clinical lab
https://read.qxmd.com/read/38314950/targeted-learning-in-observational-studies-with-multi-valued-treatments-an-evaluation-of-antipsychotic-drug-treatment-safety
#32
JOURNAL ARTICLE
Jason Poulos, Marcela Horvitz-Lennon, Katya Zelevinsky, Tudor Cristea-Platon, Thomas Huijskens, Pooja Tyagi, Jiaju Yan, Jordi Diaz, Sharon-Lise Normand
We investigate estimation of causal effects of multiple competing (multi-valued) treatments in the absence of randomization. Our work is motivated by an intention-to-treat study of the relative cardiometabolic risk of assignment to one of six commonly prescribed antipsychotic drugs in a cohort of nearly 39 000 adults with serious mental illnesses. Doubly-robust estimators, such as targeted minimum loss-based estimation (TMLE), require correct specification of either the treatment model or outcome model to ensure consistent estimation; however, common TMLE implementations estimate treatment probabilities using multiple binomial regressions rather than multinomial regression...
February 5, 2024: Statistics in Medicine
https://read.qxmd.com/read/38301100/premature-death-underlying-reasons-and-preventive-experiences-in-iran-a-narrative-review
#33
JOURNAL ARTICLE
Iman Razeghian-Jahromi, Yasin Ghasemi Mianrood, Mahintaj Dara, Pouria Azami
Premature mortality (PM) has emerged as a global health challenge. This is of eminent importance in low- and middle-income countries, where nearly three fourths of the deaths occur. The concerning issue is the early occurrence of fatal events in productive age. Fatal events before the age of 70 are called PM, which mainly result from cardiovascular diseases (CVDs). Iran as a middle- income country greatly suffers from the cardiovascular burden, which accounts for almost 50% of all PM. Despite substantial success in reducing mortality due to communicable diseases across different age ranges, urbanization and pervasiveness of cardiovascular risk factors have increased the death rate in adults in recent years...
July 1, 2023: Archives of Iranian Medicine
https://read.qxmd.com/read/38293833/exploring-the-nature-of-near-death-experiences-in-iranian-experiencers-a-case-study-of-the-participants-in-the-life-after-life-tv-series
#34
JOURNAL ARTICLE
Somayeh Mohammad Sadeghipour, Abbasali Rostami Nasab, Hamid Reza Alavi, Morad Yari Dehnavi, Abbas Mowzoon
Near-death experiences (NDEs) are complex and challenging. The development of research on NDEs helps to understand and recognize this complex human phenomenon more effectively. The present study sought to explore the nature of NDEs in the lived experiences of Iranian who experienced near-death incidents (NDErs) using a qualitative phenomenological approach. The participants were 34 persons selected from Iranian NDErs. The collected data were analyzed using Colaizzi's seven-step content analysis with MAXQDA software (version 2021)...
January 31, 2024: Omega
https://read.qxmd.com/read/38287158/near-death-experience-japan-s-moon-lander-makes-a-comeback
#35
Gemma Conroy
No abstract text is available yet for this article.
January 29, 2024: Nature
https://read.qxmd.com/read/38247230/weak-local-adaptation-to-drought-in-seedlings-of-a-widespread-conifer
#36
JOURNAL ARTICLE
Rafael Candido-Ribeiro, Sally N Aitken
Tree seedlings from populations native to drier regions are often assumed to be more drought tolerant than those from wetter provenances. However, intraspecific variation in drought tolerance has not been well-characterized despite being critical for developing climate change mitigation and adaptation strategies, and for predicting the effects of drought on forests. We used a large-scale common garden drought-to-death experiment to assess range-wide variation in drought tolerance, measured by decline of photosynthetic efficiency, growth, and plastic responses to extreme summer drought in seedlings of 73 natural populations of the two main varieties of Douglas-fir (Pseudotsuga menziesii var...
January 21, 2024: New Phytologist
https://read.qxmd.com/read/38246910/development-of-small-molecular-based-radiotracers-for-pet-imaging-of-pd-l1-expression-and-guiding-the-pd-l1-therapeutics
#37
JOURNAL ARTICLE
Hongzhang Yang, Xinying Zeng, Jia Liu, Xuejun Wen, Huanhuan Liu, Yuanyuan Liang, Xueqi Wang, Jianyang Fang, Qinglin Zhang, Jindian Li, Xianzhong Zhang, Zhide Guo
PURPOSE: Programmed cell death protein ligand 1 (PD-L1) is a crucial biomarker for immunotherapy. However, nearly 70% of patients do not respond to PD-L1 immune checkpoint therapy. Accurate monitoring of PD-L1 expression and quantification of target binding during treatment are essential. In this study, a series of small-molecule radiotracers were developed to assess PD-L1 expression and direct immunotherapy. METHODS: Radiotracers of [68 Ga]Ga-D-PMED, [68 Ga]Ga-D-PEG-PMED, and [68 Ga]Ga-D-pep-PMED were designed based on a 2-methyl-3-biphenyl methanol scaffold and successfully synthesized...
January 22, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38244249/an-investigation-of-3m-cordova-il-production-worker-s-per-and-polyfluoroalkyl-substances-biomonitoring-results-and-mortality-experience
#38
JOURNAL ARTICLE
Kara L Andres, Geary W Olsen, Ryan M Krisko, Matthew C Nunnally, Rebecca R Boeding, Karyn L Leniek, Oyebode A Taiwo
Per- and polyfluoroalkyl substances (PFAS) are a wide-ranging group of chemicals that have been used in a variety of polymer and surfactant applications. While 3M Cordova, Illinois was not one of 3M's primary manufacturing facilities for the legacy long-chain PFAS (PFOS, PFOA, PFHxS), it has been a major manufacturing site for short-chain PFAS (compounds that are or may degrade to PFBS or PFBA). The purpose of this research focused on: 1) an analysis of biomonitoring data of employees and retirees, and 2) an analysis of the cohort mortality of workers from 1970 to 2018...
January 19, 2024: International Journal of Hygiene and Environmental Health
https://read.qxmd.com/read/38243633/compassionate-presence-in-seriously-ill-cancer-patients
#39
JOURNAL ARTICLE
M Renz, C Gloggner, D Bueche, U Renz
Background : Compassion is a relational response to patients' suffering. Palliative care focuses not only on skills but also on compassion. Nevertheless, incorporated patient perspectives are largely missing from existing research. Aim : Our mixed-method exploratory study in a major Swiss cancer center sought to better understand compassionate presence, its benefits and challenges for patients and providers (ie, close relatives, close friends, and professionals-all referred to here as providers). It also investigated providers' motivation...
January 19, 2024: American Journal of Hospice & Palliative Care
https://read.qxmd.com/read/38233327/the-catastrophic-cost-of-motorcycle-road-traffic-injuries-experience-from-a-major-reference-centre-in-a-lower-middle-income-country
#40
JOURNAL ARTICLE
E O Oladeji, C Ezeme, L A Baiyewu, M O Okunola, S O Ogunlade
BACKGROUND: Motorcycle crashes are an increasing public health problem in low- and middle-income countries (LMICs). An accurate estimation of the economic burden of these crashes could be complex owing to a prevalent system of out-of-pocket (OOP) payment for health care services in these countries. Our study aims to objectively evaluate the cost implication of motorcycle Road Traffic Injuries (RTIs) among road crash victims managed at a major trauma reference hospital in Nigeria. Two economic evaluation methods were used to accurately reflect the cost-of-care (C-o-C) of each victim as well as for cross-validation...
January 4, 2024: Injury
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