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https://www.readbyqxmd.com/read/29774476/japanese-physicians-attitudes-toward-end-of-life-discussion-with-pediatric-patients-with-cancer
#1
Saran Yoshida, Chitose Ogawa, Ken Shimizu, Mariko Kobayashi, Hironobu Inoguchi, Yoshio Oshima, Chikako Dotani, Rika Nakahara, Masashi Kato
PURPOSE: We explored pediatricians' practices and attitudes concerning end-of-life discussions (EOLds) with pediatric patients with cancer, and identified the determinants of pediatricians' positive attitude toward having EOLds with pediatric patients. METHODS: A multicenter questionnaire survey was conducted with 127 pediatricians specializing in the treatment of pediatric cancer. RESULTS: Forty-two percent of participants reported that EOLds should be held with the young group of children (6-9 years old), 68% with the middle group (10-15 years old), and 93% with the old group (16-18 years old)...
May 17, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29763715/near-infrared-light-activated-red-emitting-upconverting-nanoplatform-for-t-1-weighted-magnetic-resonance-imaging-and-photodynamic-therapy
#2
Xiang-Long Tang, Jun Wu, Ben-Lan Lin, Sheng Cui, Hong-Mei Liu, Ru-Tong Yu, Xiao-Dong Shen, Ting-Wei Wang, Wei Xia
Photodynamic therapy (PDT) has increasingly become an efficient and attractive cancer treatment modality based on reactive oxygen species (ROS) that can induce tumor death after irradiation with ultraviolet or visible light. Herein, to overcome the limited tissue penetration in traditional PDT, a novel near-infrared (NIR) light-activated NaScF4 : 40% Yb, 2% Er@CaF2 upconversion nanoparticle (rUCNP) is successfully designed and synthesized. Chlorin e6, a photosensitizer and a chelating agent for Mn2+ , is loaded into human serum albumin (HSA) that further conjugates onto rUCNPs...
May 12, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29748440/meaningful-changes-in-end-of-life-care-among-patients-with-myeloma
#3
Oreofe O Odejide, Ling Li, Angel M Cronin, Anays Murillo, Paul G Richardson, Kenneth C Anderson, Gregory A Abel
Patients with advanced myeloma experience a high symptom burden particularly near the end of life, making timely hospice use crucial. Little is known about the quality and determinants of end-of-life care for this population, including if potential increases in hospice use are also accompanied by "late" enrollment (≤ 3 days before death). Using the Surveillance, Epidemiology, and End-Results-Medicare database, we identified patients ≥ 65 years diagnosed with myeloma between 2000 and 2013 that died by December 31, 2013...
May 10, 2018: Haematologica
https://www.readbyqxmd.com/read/29745132/monitoring-metabolic-reactions-in-staphylococcus-epidermidis-exposed-to-silicon-nitride-using-in-situ-time-lapse-raman-spectroscopy
#4
Francesco Boschetto, Tetsuya Adachi, Satoshi Horiguchi, Danny Fainozzi, Fulvio Parmigiani, Elia Marin, Wenliang Zhu, Bryan McEntire, Toshiro Yamamoto, Narisato Kanamura, Osam Mazda, Eriko Ohgitani, Giuseppe Pezzotti
Staphylococcus epidermidis (S. epidermidis) is one of the leading nosocomial pathogens, particularly associated with periprosthetic infections of biomedical implants. Silicon nitride (Si3N4), a nonoxide biomaterial widely used in spinal implants, has shown bacteriostatic effects against both gram-positive and gram-negative bacteria; however, the physicochemical interactions between Si3N4 and bacteria yet remain conspicuously unexplored. In situ time-lapse Raman spectroscopic experiments were conducted by exposing S...
May 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29732554/understanding-health-related-quality-of-life-in-adult-women-with-metastatic-cancer-who-have-dependent-children
#5
Eliza M Park, Allison M Deal, Justin M Yopp, Teresa Edwards, Samuel J Resnick, Mi-Kyung Song, Zev M Nakamura, Donald L Rosenstein
BACKGROUND: Cancer is a leading cause of death among women of parenting age in the United States. Women living with advanced or incurable cancer who have dependent children experience high rates of depression and anxiety as well as unique parenting challenges. To the authors' knowledge, few studies to date have examined the parenting factors associated with health-related quality of life (HRQOL) in women with advanced cancer. METHODS: The authors conducted a cross-sectional, Web-based survey of the psychosocial concerns of 224 women with a tumor-node-metastasis staging system of the AJCC stage IV solid tumor malignancy who had at least 1 child aged <18 years...
May 6, 2018: Cancer
https://www.readbyqxmd.com/read/29713941/single-stab-injuries
#6
Michael P Burke, Yeliena Baber, Zoe Cheung, Mark Fitzgerald
Determining the manner of death in cases involving multiple stab injuries from a knife is generally straightforward. The medico-legal investigation of a stabbing death caused by a single stab injury from a knife comprises a smaller but potentially more problematic subset of forensic cases. We reviewed our institute's experience with single stab injuries and endeavored to identify features identified at the post-mortem examination which may aid in the differentiation between cases of homicide, suicide and accidental death...
May 1, 2018: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/29707818/a-sensitivity-analysis-for-missing-outcomes-due-to-truncation-by-death-under-the-matched-pairs-design
#7
Kosuke Imai, Zhichao Jiang
The matched-pairs design enables researchers to efficiently infer causal effects from randomized experiments. In this paper, we exploit the key feature of the matched-pairs design and develop a sensitivity analysis for missing outcomes due to truncation by death, in which the outcomes of interest (e.g., quality of life measures) are not even well defined for some units (e.g., deceased patients). Our key idea is that if 2 nearly identical observations are paired prior to the randomization of the treatment, the missingness of one unit's outcome is informative about the potential missingness of the other unit's outcome under an alternative treatment condition...
April 29, 2018: Statistics in Medicine
https://www.readbyqxmd.com/read/29701556/estimating-the-global-incidence-of-traumatic-brain-injury
#8
Michael C Dewan, Abbas Rattani, Saksham Gupta, Ronnie E Baticulon, Ya-Ching Hung, Maria Punchak, Amit Agrawal, Amos O Adeleye, Mark G Shrime, Andrés M Rubiano, Jeffrey V Rosenfeld, Kee B Park
OBJECTIVE Traumatic brain injury (TBI)-the "silent epidemic"-contributes to worldwide death and disability more than any other traumatic insult. Yet, TBI incidence and distribution across regions and socioeconomic divides remain unknown. In an effort to promote advocacy, understanding, and targeted intervention, the authors sought to quantify the case burden of TBI across World Health Organization (WHO) regions and World Bank (WB) income groups. METHODS Open-source epidemiological data on road traffic injuries (RTIs) were used to model the incidence of TBI using literature-derived ratios...
April 27, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29676687/christopher-hitchens-public-dying-toward-a-secular-humanist-ars-moriendi
#9
Michael Brennan
This article explores the public dying of journalist, writer, provocateur, public intellectual, and renowned atheist, Christopher Hitchens. It does so primarily through an analysis of television interviews given by Hitchens following his diagnosis with esophageal cancer in June 2010. Four key themes are identified as emerging from analysis of the interviews: (a) Hitchens' explicit sense of mission in challenging myths and superstitions surrounding cancer, dying, and death; (b) the personal experience of terminal illness and dying and the particular way (or style of dying) by which it is approached; (c) issues of regret and a life well lived; and (d) questions surrounding religion, the afterlife, and possibility of deathbed conversion...
June 2018: Omega
https://www.readbyqxmd.com/read/29587726/perceptions-experiences-and-expectations-of-iraqi-medical-students
#10
Riyadh Lafta, Waleed Al-Ani, Saba Dhiaa, Megan Cherewick, Amy Hagopian, Gilbert Burnham
BACKGROUND: The environment for medical education in Iraq has been difficult for many years. The 2003 invasion of Iraq accelerated a steady emigration of faculty and graduates. Kidnappings and deaths of doctors became commonplace. To understand current career plans, expectations and perceptions of medical students, three Baghdad medical schools were surveyed. METHODS: Written questionnaires were completed by 418 medical students variously in their 4th, 5th and 6th (final)years of training...
March 27, 2018: BMC Medical Education
https://www.readbyqxmd.com/read/29584473/analysis-of-near-crashes-among-teen-young-adult-and-experienced-adult-drivers-using-the-shrp2-naturalistic-driving-study
#11
Thomas Seacrist, Ethan C Douglas, Elaine Huang, James Megariotis, Abhiti Prabahar, Abyaad Kashem, Ayya Elzarka, Leora Haber, Taryn MacKinney, Helen Loeb
OBJECTIVE: Motor vehicle crashes are the leading cause of death among young drivers. Though previous research has focused on crash events, near crashes offer additional data to help identify driver errors that could potentially lead to crashes as well as evasive maneuvers used to avoid them. The Strategic Highway Research Program 2 (SHRP2) Naturalistic Driving Study (NDS) contains extensive data on real-world driving and offers a reliable methodology to quantify and study near crashes...
February 28, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29562264/dynamics-of-floret-initiation-death-determining-spike-fertility-in-wheat-as-affected-by-ppd-genes-under-field-conditions
#12
Paula Prieto, Helga Ochagavía, Roxana Savin, Simon Griffiths, Gustavo A Slafer
As wheat yield is linearly related to grain number, understanding the physiological determinants of the number of fertile florets based on floret development dynamics due to the role of the particular genes is relevant. The effects of photoperiod genes on dynamics of floret development are largely ignored. Field experiments were carried out to (i) characterize the dynamics of floret primordia initiation and degeneration and (ii) to determine which are the most critical traits of such dynamics in establishing genotypic differences in the number of fertile florets at anthesis in near isogenic lines (NILs) carrying photoperiod insensitive alleles...
March 19, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29558745/telenephrology-providing-healthcare-to-remotely-located-patients-with-chronic-kidney-disease
#13
Judy Tan, Anita Mehrotra, Girish N Nadkarni, John Cijiang He, Erik Langhoff, James Post, Carlos Galvao-Sobrinho, Henry C Thode, Rajeev Rohatgi
BACKGROUND: Chronic kidney disease (CKD) patients who live far (>30 miles) from their nephrologist experience lower rates of clinic visit adherence, limited access to treatment, and higher rates of hospitalization and mortality than patients who live in close proximity to their nephrologist. Strategies to minimize disparities between urban and remotely located CKD patients are needed. The purpose of this study was to determine whether adherence to clinic visits and clinical outcomes in the remote management of CKD via telenephrology is comparable to in-person conventional care...
2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29556825/breast-organotypic-cancer-models
#14
Pilar Carranza-Rosales, Nancy Elena Guzmán-Delgado, Irma Edith Carranza-Torres, Ezequiel Viveros-Valdez, Javier Morán-Martínez
Breast cancer is the most common cancer type diagnosed in women, it represents a critical public health problem worldwide, with 1,671,149 estimated new cases and nearly 571,000 related deaths. Research on breast cancer has mainly been conducted using two-dimensional (2D) cell cultures and animal models. The usefulness of these models is reflected in the vast knowledge accumulated over the past decades. However, considering that animal models are three-dimensional (3D) in nature, the validity of the studies using 2D cell cultures has recently been questioned...
March 20, 2018: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/29546457/nonlinear-studies-of-tumor-morphological-stability-using-a-two-fluid-flow-model
#15
Kara Pham, Emma Turian, Kai Liu, Shuwang Li, John Lowengrub
We consider the nonlinear dynamics of an avascular tumor at the tissue scale using a two-fluid flow Stokes model, where the viscosity of the tumor and host microenvironment may be different. The viscosities reflect the combined properties of cell and extracellular matrix mixtures. We perform a linear morphological stability analysis of the tumors, and we investigate the role of nonlinearity using boundary-integral simulations in two dimensions. The tumor is non-necrotic, although cell death may occur through apoptosis...
March 15, 2018: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/29540307/oxidative-cross-linking-of-proteins-to-dna-following-ischemia-reperfusion-injury
#16
Arnold Groehler, Stefan Kren, Qinglu Li, Maggie Robledo-Villafane, Joshua Schmidt, Mary Garry, Natalia Tretyakova
Myocardial infarction (MI) is a life-threatening condition that can occur when blood flow to the heart is interrupted due to a blockage in one or more of the coronary vessels. Current treatments of MI rapidly restore blood flow to the affected myocardium using thrombolytic agents or angioplasty. Adverse effects including inflammation, tissue necrosis, and ventricular dysfunction are, however, not uncommon following reperfusion therapy. These conditions are thought to be caused by a sudden influx of reactive oxygen species (ROS) to the affected myocardium...
May 20, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29515509/-the-less-i-think-about-it-the-better-i-feel-a-thematic-analysis-of-the-subjective-experience-of-malignant-mesothelioma-patients-and-their-caregivers
#17
Fanny Guglielmucci, Isabella G Franzoi, Michela Bonafede, Francesca V Borgogno, Federica Grosso, Antonella Granieri
Aim: A cancer diagnosis-and in particular a Malignant Mesothelioma (MM) one-breaks the somatopsychic balance of the individual, compromising the quality of residual life and giving rise to many negative emotions difficult to integrate and to elaborate (such as depression, fears, anxieties, hopelessness, guilt, shame, and rage). Several national and international guidelines acknowledged the importance of evaluating psychological and socio-relational features in MM patients and their caregiver. However, only few studies have investigated the subjective experience of MM patients and even less research has focused on the caregivers' experience...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29514159/ten-year-survival-of-end-stage-renal-disease-patients-treated-with-high-efficiency-online-hemodiafiltration-a-cohort-study-of-a-center-in-south-east-asia
#18
Khajohn Tiranathanagul, Paweena Susantitaphong, Nattachai Srisawat, Nanta Mahatanan, Kriang Tungsanga, Kearkiat Praditpornsilpa, Somchai Eiam-Ong
BACKGROUND: Recently, in the first hemodiafiltration (HDF) experience report from South East Asia (SEA), we reported a 3-year prospective study demonstrating the various short-term benefits of high-efficiency online HDF (OL-HDF) over high-flux hemodialysis (HD). Very few long-term survival reports of high-efficiency OL-HDF are available and the data are heterogeneous and incomplete. OBJECTIVES: The present historical cohort study was conducted to determine the long-term survival and outcome of high-efficiency OL-HDF-treated patients...
March 7, 2018: Nephron
https://www.readbyqxmd.com/read/29499865/ten-year-clinical-experience-of-humanitarian-cardiothoracic-surgery-in-rwanda-building-a-platform-for-ultimate-sustainability-in-a-resource-limited-setting
#19
JaBaris D Swain, Colleen Sinnott, Suellen Breakey, Rian Hasson Charles, Gita Mody, Napthal Nyirimanzi, Ceeya Patton-Bolman, Patricia Come, Gapira Ganza, Emmanuel Rusingiza, Nathan Ruhamya, Joseph Mucumbitsi, Jorge Borges, Martin Zammert, Jochen D Muehlschlegel, Robert Oakes, Bruce Leavitt, R Morton Bolman
OBJECTIVE: Despite its near complete eradication in resource-rich countries, rheumatic heart disease remains the most common acquired cardiovascular disease in sub-Saharan Africa. With a ratio of physicians/population of 1 per 10,500, including only 4 cardiologists for a population of 11.4 million, Rwanda represents a resource-limited setting lacking the local capacity to detect and treat early cases of strep throat and perform lifesaving operations for advanced rheumatic heart disease...
February 27, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29499235/family-caregivers-preparations-for-death-a-qualitative-analysis
#20
Lauren J Breen, Samar M Aoun, Moira O'Connor, Denise Howting, Georgia K B Halkett
CONTEXT: Many family caregivers are not prepared for the death of their family member or friend. Palliative care services tend to emphasize the patients' preparation for death rather than caregivers' preparation for, or living after, death. Caregivers' perspectives on anticipating and preparing for death are under-researched, despite preparation being associated with better bereavement outcomes. OBJECTIVES: The objective was to explore family caregivers' preparations for death...
June 2018: Journal of Pain and Symptom Management
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