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https://www.readbyqxmd.com/read/28105957/identification-of-nuclear-genes-controlling-chlorophyll-synthesis-in%C3%A2-barley-by-rna-seq
#1
Nickolay A Shmakov, Gennadiy V Vasiliev, Natalya V Shatskaya, Alexey V Doroshkov, Elena I Gordeeva, Dmitry A Afonnikov, Elena K Khlestkina
BACKGROUND: Albinism in plants is characterized by lack of chlorophyll and results in photosynthesis impairment, abnormal plant development and premature death. These abnormalities are frequently encountered in interspecific crosses and tissue culture experiments. Analysis of albino mutant phenotypes with full or partial chlorophyll deficiency can shed light on genetic determinants and molecular mechanisms of albinism. Here we report analysis of RNA-seq transcription profiling of barley (Hordeum vulgare L...
November 16, 2016: BMC Plant Biology
https://www.readbyqxmd.com/read/28100825/understanding-the-cognitive-experience-of-death-and-the-near-death-experience
#2
REVIEW
S Parnia
No abstract text is available yet for this article.
November 8, 2016: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28098631/after-the-fall-the-tapestry-of-disturbance-and-recovery
#3
Nalini M Nadkarni
On July 3, 2015, Nalini Nadkarni, a world-renowned ecologist who had been studying the biologic processes of ecosystem disturbance and recovery, sustained a catastrophic 50-foot free-fall from the top of the rainforest canopy to the forest floor at her remote field research site. She lost consciousness in shock and sustained life-threatening injuries. Her accompanying students hiked out, radio-called 911, and the Harborview Medical Center (Seattle) Medivac team arrived 4 hours later to rescue her. Her prognosis was extremely grim; her family gathered in anticipation of her death as she underwent four operations during her 10 days in the ICU...
February 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28067605/near-death-experiences-posttraumatic-growth-and-life-satisfaction-among-burn-survivors
#4
David Royse, Karen Badger
Survivors of large burns may face positive and negative psychological after-effects from close-to-death injuries. This study is the first to examine their near-death experiences (NDEs) and posttraumatic growth (PTG) and life satisfaction afterwards. With an available sample of 92 burn survivors, half met the criteria for an NDE using an objective scale. Those who indicated religion was a source of strength and comfort had high scores on life satisfaction, PTG, and the NDE Scale. Individuals with larger burns reported greater PTG than those with smaller total body surface area burned (TBSA)...
January 9, 2017: Social Work in Health Care
https://www.readbyqxmd.com/read/28063407/synthesis-and-in-vitro-photodynamic-therapy-of-chlorin-derivative-13-1-ortho-trifluoromethyl-phenylhydrazone-modified-pyropheophorbide-a
#5
Jianjun Cheng, Wenting Li, Guanghui Tan, Zhiqiang Wang, Shuying Li, Yingxue Jin
Photodynamic therapy (PDT) is entering the mainstream of the cancer treatments recently. Pyropheophorbide-a (Pa), as a degradation product of chlorophyll-a, has been shown to be a potent photosensitizer in photodynamic therapy. In this paper, we investigated the in vitro photodynamic therapy of 13(1)-ortho-trifluoromethyl-phenylhydrazone modified pyropheophorbide-a (PHPa) against human HeLa cervical cancer cell line, together with ultraviolet-visible spectra, fluorescence emission spectra, stability in various solvents, and single oxygen quantum yield...
January 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28056561/survey-of-abdominal-access-and-associated-morbidity-for-robot-assisted-radical-prostatectomy-rarp-does-palmer-s-point-warrant-further-awareness-and-study
#6
William K Johnston Iii, Susan Linsell, David Christopher Miller, Khurshid R Ghani
INTRODUCTION: Laparoscopic access for RARP is often initiated in the peri-umbilical location. Palmer's Point, located in the left upper quadrant, has been reported as an alternative access site for pelvic laparoscopy to reduce morbidity, but not widely reported among urologists. To better understand surgeons' preferences for access and its associated morbidity during RARP, we surveyed surgeons from two urological organizations. METHODS: An anonymous online questionnaire that assessed training, experience, and preferences for RARP was emailed in December 2014 to members of the Endourology Society (ES) and the Michigan Urological Society Improvement Collaborative (MUSIC) ...
January 5, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28052373/best-time-window-for-the-use-of-calcium-modulating-agents-to-improve-functional-recovery-in-injured-peripheral-nerves-an-experiment-in-rats
#7
Yuhui Yan, Feng-Yi Shen, Michael Agresti, Lin-Ling Zhang, Hani S Matloub, John A LoGiudice, Robert Havlik, Jifeng Li, Yu-Dong Gu, Ji-Geng Yan
Peripheral nerve injury can have a devastating effect on daily life. Calcium concentrations in nerve fibers drastically increase after nerve injury, and this activates downstream processes leading to neuron death. Our previous studies showed that calcium-modulating agents decrease calcium accumulation, which aids in regeneration of injured peripheral nerves; however, the optimal therapeutic window for this application has not yet been identified. In this study, we show that calcium clearance after nerve injury is positively correlated with functional recovery in rats suffering from a crushed sciatic nerve injury...
January 4, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28048943/modeling-small-angle-x-ray-scattering-data-for-low-density-lipoproteins-insights-into-the-fatty-core-phase-packing-and-transition
#8
Selma Maric, Tania Kjellerup Lind, Jeppe Lyngsø, Marite Cardenas, Jan Skov Pedersen
Atherosclerosis and its clinical consequences are the leading cause of death in the west. While many studies throughout the last decades have aimed at understanding the disease, the clinical markers in use today still fail to accurately predict the risks. The role of the main clinical indicator of today, the low density lipoprotein (LDL), in depositing fat to the vessel wall is believed to be the onset of the process. However, many subfractions of the LDL, which differ both in structure and composition, are present in the blood and amongst different individuals...
January 3, 2017: ACS Nano
https://www.readbyqxmd.com/read/28044473/synthesis-characterization-and-in-vitro-evaluation-of-targeted-gold-nanoshelled-poly-d-l-lactide-co-glycolide-nanoparticles-carrying-anti-p53-antibody-as-a-theranostic-agent-for-ultrasound-contrast-imaging-and-photothermal-therapy
#9
Li Xu, Caifeng Wan, Jing Du, Hongli Li, Xuesong Liu, Hong Yang, Fenghua Li
Breast cancer is the leading cause of cancer-related deaths in women and earlier detection can substantially reduce deaths from breast cancer. Polymers with targeted ligands are widely used in the field of molecular ultrasound imaging and targeted tumor therapy. In our study, the nanotheranostic agent was fabricated through filling perfluoropropane (C3F8) into poly(d,l-lactic-co-glycolic acid) nanoparticles (PLGA NPs), followed by the formation of gold nanoshell on the surface, then conjugated with anti p53 antibody which has high specificity with the p53 protein overexpressing in breast cancer...
January 16, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28044263/five-fraction-stereotactic-body-radiation-therapy-sbrt-and-chemotherapy-for-the-local-management-of-metastatic-pancreatic-cancer
#10
Jonathan W Lischalk, Aidan Burke, Jessica Chew, Christen Elledge, Marie Gurka, John Marshall, Michael Pishvaian, Sean Collins, Keith Unger
BACKGROUND: The majority of patients with pancreatic cancer are diagnosed with metastatic disease at presentation. Nevertheless, local progression is responsible for up to 30% of deaths and can lead to significant morbidity. As a consequence, further exploration of effective methods of local control and palliation is essential. Stereotactic body radiation therapy (SBRT) is a widely utilized technique for the treatment of localized pancreatic cancer. Here, we report our experience with SBRT and chemotherapy for the local treatment of the metastatic patient population...
January 3, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28042064/homeless-individuals-approaching-the-end-of-life-symptoms-and-attitudes
#11
Matthew Tobey, Julia Manasson, Kristen Decarlo, Katrina Ciraldo-Maryniuk, Jessie M Gaeta, Erica Wilson
CONTEXT: Over a million individuals in the United States experience homelessness annually and homeless individuals die at a higher rate than domiciled peers. Homeless individuals often have unique experiences at the end of life (EOL). OBJECTIVES: This study examined the symptoms experienced by homeless individuals nearing the EOL and explored social background, attitudes and experiences. METHODS: Investigators conducted surveys of homeless individuals approaching the EOL at a medical respite home...
December 29, 2016: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28031417/serious-illness-conversations-in-esrd
#12
Ernest I Mandel, Rachelle E Bernacki, Susan D Block
Dialysis-dependent ESRD is a serious illness with high disease burden, morbidity, and mortality. Mortality in the first year on dialysis for individuals over age 75 years old approaches 40%, and even those with better prognoses face multiple hospitalizations and declining functional status. In the last month of life, patients on dialysis over age 65 years old experience higher rates of hospitalization, intensive care unit admission, procedures, and death in hospital than patients with cancer or heart failure, while using hospice services less...
December 28, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28030494/traumatic-colon-injury-in-damage-control-laparotomy-a-multicenter-trial-is-it-safe-to-do-a-delayed-anastomosis
#13
Leah Tatebe, Andrew Jennings, Ken Tatebe, Alexandra Handy, Purvi Prajapati, Michael Smith, Tai Do, Gerald O Ogola, Rajesh R Gandhi, Therese M Duane, Stephen Luk, Laura B Petrey
BACKGROUND: Delayed colonic anastomosis after damage control laparotomy (DCL) is an alternative to colostomies during a single laparotomy (SL) in high-risk patients. However, literature suggests increased colonic leak rates up to 27% with DCL, and various reported risk factors. We evaluated our regional experience to determine if delayed colonic anastomosis was associated with worse outcomes. METHODS: A multi-center retrospective cohort study was performed across three Level I Trauma Centers encompassing traumatic colon injuries from January 2006 through June 2014...
December 23, 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28030476/socioeconomic-disparities-in-mortality-among-women-with-incident-breast-cancer-before-and-after-implementation-of-medicare-part-d
#14
Ann B Nattinger, Erica M Wozniak, Emily L McGinley, Jianing Li, Purushottam Laud, Liliana E Pezzin
BACKGROUND: Breast cancer patients exhibit survival disparities based on socioeconomic status (SES). Disparities may be attributable to access to expensive oral endocrine agents. OBJECTIVES: Define recent socioeconomic disparities in breast cancer survival and determine whether these improved after implementation of the Medicare Part D program. DESIGN: Difference-in-difference natural experiment of women diagnosed and treated before or after implementation of Medicare Part D...
December 27, 2016: Medical Care
https://www.readbyqxmd.com/read/28004543/investigating-near-death-experiences
#15
Øystein Buer, Mary Kalfoss, Lars Weisæth, Bjørn Bendz
No abstract text is available yet for this article.
December 2016: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://www.readbyqxmd.com/read/28003180/years-of-life-and-productivity-lost-from-potentially-avoidable-colorectal-cancer-deaths-in-us-counties-with-lower-educational-attainment-2008-2012
#16
Hannah K Weir, Chunyu Li, S Jane Henley, Djenaba Joseph
BACKGROUND: Educational-attainment (EA) is inversely associated with colorectal cancer (CRC) risk. CRC Screening can save lives if precancerous polyps or early cancers are found and successfully treated. This study aims to estimate the potential productivity loss (PPL) and associated avoidable CRC deaths among screen eligible adults residing in lower EA counties in the United States. METHODS: Mortality and population data were used to examine CRC deaths (2008-2012) among adults aged 50 to 74 years in lower EA counties, and to estimate the expected number of deaths using the mortality experience from high EA counties...
December 21, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27983872/recovery-of-dysphagia-symptoms-after-oral-endotracheal-intubation-in-ards-survivors-a-5-year-longitudinal-study
#17
Martin B Brodsky, Minxuan Huang, Carl Shanholtz, Pedro A Mendez-Tellez, Jeffrey B Palmer, Elizabeth Colantuoni, Dale M Needham
RATIONALE: Nearly 60% of patients who are intubated in intensive care units (ICUs) experience dysphagia after extubation, and approximately 50% of them aspirate. Little is known about dysphagia recovery time after patients are discharged from the hospital. OBJECTIVE: To determine factors associated with recovery from dysphagia symptoms after hospital discharge for acute respiratory distress syndrome (ARDS) survivors who received oral intubation with mechanical ventilation...
December 16, 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27941452/use-of-simulation-in-end-of-life-care-education
#18
Debra Grabow
Death and dying encompasses the period when individuals present with a limited prognosis and are near death or have recently died. Using simulation to educate nurses on end-of-life (EOL) care helps focus more on the needs of the learner rather than the patient, and allows the learner to process feelings in preparation for a real experience. Incorporating simulation with a spiritual perspective is essential and needed in EOL nursing care.
January 2017: Journal of Christian Nursing: a Quarterly Publication of Nurses Christian Fellowship
https://www.readbyqxmd.com/read/27922909/research-on-experiences-related-to-the-possibility-of-consciousness-beyond-the-brain-a-bibliometric-analysis-of-global-scientific-output
#19
Jorge Cecílio Daher, Rodolfo Furlan Damiano, Alessandra Lamas Granero Lucchetti, Alexander Moreira-Almeida, Giancarlo Lucchetti
This study aims to conduct a search of publications investigating experiences commonly associated with the possibility of the existence of a consciousness independent of the brain held on the main scientific databases (Pubmed, Web of Knowledge, PsycINFO, Science Direct, and Scopus). Of the 9065 articles retrieved, 1954 were included (598 near-death experiences, 223 out-of-body experiences, 56 end-of-life experiences, 224 possession, 244 memories suggestive of past lives, 565 mediumship, 44 others). Over the decades, there was an evident increase in the number of articles on all the areas of the field, with the exception of studies on mediumship that showed a decline during the late 20th century and subsequent rise in the early 21st century...
January 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/27918858/d10-in-the-treatment-of-prehospital-hypoglycemia-a-24-month-observational-cohort-study
#20
H Gene Hern, Matthew Kiefer, Derex Louie, Joseph Barger, Harrison J Alter
INTRODUCTION: Prehospital first responders historically have used an IV bolus of 50 mL of 50% dextrose solution (D50) for the treatment of hypoglycemia in the field. A local Emergency Medical Services (EMS) system recently approved a hypoglycemia treatment protocol of IV 10% dextrose solution (D10) due to occasional shortages and higher cost of D50. We use the experience of this EMS system to report the feasibility, safety, and efficacy of this approach. METHODS: Over the course of 104 weeks, paramedics treated 1,323 hypoglycemic patients with D10 and recorded patient demographics and clinical outcomes...
December 5, 2016: Prehospital Emergency Care
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