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https://www.readbyqxmd.com/read/29326012/stereotactic-body-radiotherapy-sbrt-for-patients-with-locally-advanced-pancreatic-cancer-a-single-center-experience
#1
Raphaël Jumeau, Guila Delouya, David Roberge, David Donath, Dominic Béliveau-Nadeau, Marie-Pierre Campeau
INTRODUCTION: Despite advances in treatment, notably in systemic therapy, the prognosis of pancreatic adenocarcinoma (PADC) remains dismal. Stereotactic body radiotherapy (SBRT) is an emerging tool in the complex management of PADC. We review outcomes of SBRT for PADC at our institution. METHODS: We reviewed patients treated with SBRT for either unresectable PADC or locally recurrent PADC after surgery. Treatment was delivered using a robotic radiosurgery system with respiratory tracking...
December 21, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29315331/epormenis-cestri-secretions-in-sebastiania-schottiana-trees-cause-mass-death-of-honey-bee-apis-mellifera-larvae-in-uruguay
#2
Ciro Invernizzi, Enrique Nogueira, Pablo Juri, Estela Santos, Daniela Arredondo, Belén Branchiccela, Yamandú Mendoza, Karina Antúnez
For more than 60 years, sporadic cases of massive summer honey bee larvae mortality in colonies located near freshwater systems with abundant riparian vegetation have been reported in Uruguay. This odd phenomenon, known as "River disease" by beekeepers, can lead to colony death by depopulation. The aim of this study was to detect the causes of larvae death. Different experiments and analyses were performed using affected apiaries located between two important water courses. 1 day old larvae were the most susceptible and substances that killed the larvae were present in the nectar but not in the pollen...
2018: PloS One
https://www.readbyqxmd.com/read/29303230/planned-birth-at-or-near-term-for-improving-health-outcomes-for-pregnant-women-with-gestational-diabetes-and-their-infants
#3
REVIEW
Linda M Biesty, Aoife M Egan, Fidelma Dunne, Eugene Dempsey, Pauline Meskell, Valerie Smith, G Meabh Ni Bhuinneain, Declan Devane
BACKGROUND: Gestational diabetes is a type of diabetes that occurs during pregnancy. Women with gestational diabetes are more likely to experience adverse health outcomes such as pre-eclampsia or polyhydramnios (excess amniotic fluid). Their babies are also more likely to have health complications such as macrosomia (birthweight > 4000 g) and being large-for-gestational age (birthweight above the 90th percentile for gestational age). Current clinical guidelines support elective birth, at or near term in women with gestational diabetes to minimise perinatal complications, especially those related to macrosomia...
January 5, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29289705/molecular-imaging-of-tumor-photoimmunotherapy-evidence-of-photosensitized-tumor-necrosis-and-hemodynamic-changes
#4
Shun Kishimoto, Nobu Oshima, Kazutoshi Yamamoto, Jeeva Munasinghe, Jan Henrik Ardenkjaer-Larsen, James B Mitchell, Peter L Choyke, Murali C Krishna
Near-infrared photoimmunotherapy (NIR PIT) employs the photoabsorbing dye IR700 conjugated to antibodies specific for cell surface epidermal growth factor receptor (EGFR). NIR PIT has shown highly selective cytotoxicity in vitro and in vivo. Cell necrosis is thought to be the main mode of cytotoxicity based mainly on in vitro studies. To better understand the acute effects of NIR PIT, molecular imaging studies were performed to assess its cellular and vascular effects. In addition to in vitro studies for cytotoxicity of NIR PIT, the in vivo tumoricidal effects and hemodynamic changes induced by NIR PIT were evaluated by 13C MRI using hyperpolarized [1,4-13C2] fumarate, R2* mapping from T2*-weighted MRI, and photoacoustic imaging...
December 29, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29288393/procedural-complications-of-endovascular-treatment-in-patients-with-aneurysmal-subarachnoid-haemorrhage-treated-at-a-single-centre
#5
Mikko Alanen, Liisa Pyysalo, Iiro Jalava, Oona Snicker, Juha-Pekka Pienimäki, Juha Öhman, Antti Ronkainen
BACKGROUND: We present a single-centre experience of procedural complications suffered by patients undergoing endovascular treatment for a ruptured saccular intracranial aneurysm at Tampere University Hospital, Finland, between 2000 and 2014. METHOD: From 2000 to 2014, we treated 1,253 patients with aneurysmal subarachnoid haemorrhage, 491 of whom received endovascular treatment. Clinical data were collected retrospectively from the hospital's aneurysm database...
December 29, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29278365/sexually-dimorphic-outcomes-after-neonatal-stroke-and-hypoxia-ischemia
#6
REVIEW
Christiane Charriaut-Marlangue, Valérie C Besson, Olivier Baud
Cohort studies have demonstrated a higher vulnerability in males towards ischemic and/or hypoxic-ischemic injury in infants born near- or full-term. Male sex was also associated with limited brain repair following neonatal stroke and hypoxia-ischemia, leading to increased incidence of long-term cognitive deficits compared to females with similar brain injury. As a result, the design of pre-clinical experiments considering sex as an important variable was supported and investigated because neuroprotective strategies to reduce brain injury demonstrated sexual dimorphism...
December 26, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29242248/causes-of-death-after-a-hospitalization-with-aki
#7
Samuel A Silver, Ziv Harel, Eric McArthur, Danielle M Nash, Rey Acedillo, Abhijat Kitchlu, Amit X Garg, Glenn M Chertow, Chaim M Bell, Ron Wald
Mortality after AKI is high, but the causes of death are not well described. To better understand causes of death in patients after a hospitalization with AKI and to determine patient and hospital factors associated with mortality, we conducted a population-based study of residents in Ontario, Canada, who survived a hospitalization with AKI from 2003 to 2013. Using linked administrative databases, we categorized cause of death in the year after hospital discharge as cardiovascular, cancer, infection-related, or other...
December 14, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29235388/early-outcomes-of-the-t-branch-off-the-shelf-multibranched-stent-graft-in-urgent-thoracoabdominal-aortic-aneurysm-repair
#8
Konstantinos Spanos, Tilo Kölbel, Myrto Theodorakopoulou, Franziska Heidemann, Fiona Rohlffs, Eike Sebastian Debus, Nikolaos Tsilimparis
PURPOSE: To assess the short-term outcomes of the multibranched off-the-shelf t-Branch stent-graft for urgent thoracoabdominal aortic aneurysm (TAAA) repair and to evaluate the impact on outcomes of the learning curve and adherence to the instruction for use (IFU). METHODS: Between 2014 and 2017, 42 patients (mean age 73.3±7 years; 26 men) underwent urgent TAAA treatment using the t-Branch stent-graft [18 in the early (2014-2015) period and 24 in the late (2016-2017) period]...
December 1, 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/29201415/contraceptive-utilization-and-associated-factors-among-women-of-reproductive-age-group-in-southern-nations-nationalities-and-peoples-region-ethiopia-cross-sectional-survey-mixed-methods
#9
Misganu Endriyas, Akine Eshete, Emebet Mekonnen, Tebeje Misganaw, Mekonnen Shiferaw, Sinafikish Ayele
Background: Though contraceptive utilization has comprehensive benefit for women, it was one of underutilized public intervention in Ethiopia and in the study area. Thus, assessing status and factors affecting contraceptive utilization among women of reproductive age group was found key step for program improvement. Methods: Community based cross-sectional study was conducted from March to April, 2015 in Southern Nations and Nationalities Peoples' Region, Ethiopia...
2017: Contraception and Reproductive Medicine
https://www.readbyqxmd.com/read/29188026/is-temperature-an-important-variable-in-recovery-after-mild-traumatic-brain-injury
#10
REVIEW
Coleen M Atkins, Helen M Bramlett, W Dalton Dietrich
With nearly 42 million mild traumatic brain injuries (mTBIs) occurring worldwide every year, understanding the factors that may adversely influence recovery after mTBI is important for developing guidelines in mTBI management. Extensive clinical evidence exists documenting the detrimental effects of elevated temperature levels on recovery after moderate to severe TBI. However, whether elevated temperature alters recovery after mTBI or concussion is an active area of investigation. Individuals engaged in exercise and competitive sports regularly experience body and brain temperature increases to hyperthermic levels and these temperature increases are prolonged in hot and humid ambient environments...
2017: F1000Research
https://www.readbyqxmd.com/read/29178334/suppression-of-oxidative-phosphorylation-confers-resistance-against-bevacizumab-in-experimental-glioma
#11
Jule A Eriksson, Christina Wanka, Michael C Burger, Hans Urban, Ines Hartel, Janusz von Renesse, Patrick N Harter, Michel Mittelbronn, Joachim P Steinbach, Johannes Rieger
Although bevacizumab initially shows high response rates in gliomas and other tumors, therapy resistance usually develops later. Because antiangiogenic agents are supposed to induce hypoxia, we asked whether rendering glioma cells independent of oxidative phosphorylation modulates their sensitivity against hypoxia and bevacizumab. LNT-229 glioma cells without functional mitochondria (rho0 ) and control (rho+ ) cells were generated. LNT-229 rho0 -cells displayed reduced expression of oxidative phosphorylation-related genes and diminished oxygen consumption...
November 27, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29175140/comparison-of-in-vivo-targeting-ability-between-crgd-and-collagen-targeting-peptide-conjugated-nano-carriers-for-atherosclerosis
#12
Manse Kim, Abhishek Sahu, Gi Beom Kim, Gi Hoon Nam, Wooram Um, So Jin Shin, Yong Yeon Jeong, In-San Kim, Kwangmeyung Kim, Ick Chan Kwon, Giyoong Tae
Atherosclerosis plaque is a major cause of cardiovascular diseases across the globe and a silent killer. There are no physical symptoms of the disease in its early stage and current diagnostic techniques cannot detect the small plaques effectively or safely. Plaques formed in blood vessels can cause serious clinical problems such as impaired blood flow or sudden death, regardless of their size. Thus, detecting early stage of plaques is especially more important to effectively reduce the risk of atherosclerosis...
November 21, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29174783/improving-results-of-surgery-for-ebstein-anomaly-where-are-we-after-235-cone-repairs
#13
Kimberly A Holst, Joseph A Dearani, Sameh Said, Roxann B Pike, Heidi M Connolly, Bryan C Cannon, Kristen L Sessions, Megan M O'Byrne, Patrick W O'Leary
BACKGROUND: Ebstein anomaly has heterogeneous anatomy and numerous operative techniques are described. Cone repair provides a near anatomic tricuspid valve repair. The purpose of this study was to examine our experience with cone repair. METHODS: Cone repair was performed in 235 consecutive patients with Ebstein anomaly, 134 children (57%) and 101 adults (43%), from June 2007 to October 2015. Median age was 15.6 years (range, 6 months to 73 years). Cone repair was the first operation in 192 patients (82%), the second in 41 (17%), and the third in 2 (1%)...
January 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29173831/an-exploration-of-medical-emergency-team-intervention-at-the-end-of-life-for-people-with-advanced-cancer
#14
Christine Brown, Allison Drosdowsky, Meinir Krishnasamy
PURPOSE: Recent advances in cancer therapies offer survival benefit when cure is no longer possible. The contribution of the Medical Emergency Teams (METs) in the context of advancing disease has received little empirical consideration. This study set out to explore MET intervention at the end of life for people with advanced cancer in an Australian comprehensive cancer centre, and its impact on quality of death. METHOD: A retrospective medical chart review was undertaken to explore MET response for people with advanced (incurable) cancer nearing end of life...
December 2017: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/29166390/criticism-by-community-people-and-poor-workplace-communication-as-risk-factors-for-the-mental-health-of-local-welfare-workers-after-the-great-east-japan-earthquake-a-cross-sectional-study
#15
Ikki Ueda, Atsushi Sakuma, Yoko Takahashi, Wataru Shoji, Ayami Nagao, Mikika Abe, Yuriko Suzuki, Hiroo Matsuoka, Kazunori Matsumoto
After a large-scale natural disaster, demand for social welfare services increases, and the mental health of local social welfare workers becomes a matter of great concern because of their dual role as support providers and disaster survivors. We examined whether work-related social stressors, including criticism by community people and poor workplace communication, were associated with increased risk of post-traumatic stress disorder (PTSD), depression, or psychological distress 20-22 months after the Great East Japan Earthquake (GEJE; March 11, 2011) in local social welfare workers...
2017: PloS One
https://www.readbyqxmd.com/read/29095071/n-n-dimethyltryptamine-and-the-pineal-gland-separating-fact-from-myth
#16
David E Nichols
The pineal gland has a romantic history, from pharaonic Egypt, where it was equated with the eye of Horus, through various religious traditions, where it was considered the seat of the soul, the third eye, etc. Recent incarnations of these notions have suggested that N,N-dimethyltryptamine is secreted by the pineal gland at birth, during dreaming, and at near death to produce out of body experiences. Scientific evidence, however, is not consistent with these ideas. The adult pineal gland weighs less than 0...
October 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29078888/long-term-survival-after-resection-of-sarcomatoid-carcinoma-of-the-pancreas-an-updated-experience
#17
Alex B Blair, Richard A Burkhart, James F Griffin, James A Miller, Matthew J Weiss, John L Cameron, Christopher L Wolfgang, Jin He
BACKGROUND: Sarcomatoid carcinoma of the pancreas (SCP) is a rare histologic subtype of undifferentiated pancreatic carcinoma. Historically, this has been associated with a worse overall prognosis than adenocarcinoma. However, the clinical course and surgical outcomes of SCP remain poorly characterized owing to its rarity. METHODS: A single-institution, prospectively maintained database was queried for patients who underwent pancreatic resection with a final diagnosis of SCP...
November 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29065871/q-a-cellular-near-death-experiences-what-is-anastasis
#18
Gongping Sun, Denise J Montell
Apoptosis is a form of programmed cell death that is carried out by proteolytic enzymes called caspases. Executioner caspase activity causes cells to shrink, bleb, and disintegrate into apoptotic bodies and has been considered a point of no return for apoptotic cells. However, relatively recent work has shown that cells can survive transient apoptotic stimuli, even after executioner caspase activation. This process is called anastasis. In this Q&A, we answer common questions that arise regarding anastasis, including how it is defined, the origin of the name, the potential physiological consequences, molecular mechanisms, and open questions for this new field of study...
October 24, 2017: BMC Biology
https://www.readbyqxmd.com/read/29045916/suicide-deaths-among-patients-with-end-stage-renal-disease-receiving-dialysis-a-population-based-retrospective-cohort-study-of-64-000-patients-in-taiwan
#19
I-Ming Chen, Po-Hsien Lin, Vin-Cent Wu, Chi-Shin Wu, Jia-Chi Shan, Shu-Sen Chang, Shih-Cheng Liao
BACKGROUND: Patients with end-stage renal disease (ESRD) who receive dialysis may experience increased distress and risk of suicide. METHODS: This population-based retrospective cohort study linked Taiwan's national register of ESRD patients on dialysis and the cause-of-death mortality data file. A separate multiple-cause-of-death data file was used to investigate the detailed suicide methods used. Standardized mortality ratios (SMRs) were calculated for the overall patient group and by sex, age, year of initiating dialysis, method of suicide, and time since initiation of dialysis...
October 9, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29044801/differential-physiological-responses-to-central-leptin-overexpression-in-male-and-female-rats
#20
Isabelle Côté, Sara M Green, Hale Z Toklu, Drake Morgan, Christy S Carter, Nihal Tümer, Philip J Scarpace
Brains of females are more sensitive to the acute catabolic actions of leptin. However, sex differences in the long-term physiological responses to central leptin receptor modulation are unknown. To this end, we centrally delivered a viral vector to overexpress leptin (Leptin), a neutral leptin receptor antagonist (Leptin-Antagonist), or a green fluorescence protein (Control). We examined chronic changes in body weight and composition in male and female rats. Females displayed greater and sustained responses to Leptin whereas males rapidly lost physiological effects and developed leptin resistance confirmed by lower acute leptin-mediated phosphorylation of STAT3 (P-STAT3)...
October 17, 2017: Journal of Neuroendocrinology
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