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miliary tuberculosis

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https://www.readbyqxmd.com/read/28626190/miliary-tuberculosis-in-a-young-woman-with-hemophagocytic-syndrome-a-case-report-and-literature-review
#1
Mina Asaji, Kazunori Tobino, Koujin Murakami, Yuki Goto, Takuto Sueyasu, Saori Nishizawa, Kohei Yoshimine, Miyuki Munechika, Yuki Ko, Yuki Yoshimatsu, Kosuke Tsuruno, Hiromi Ide, Hiroyuki Miyajima, Noriyuki Ebi
We herein report a rare case of miliary tuberculosis-associated hemophagocytic syndrome (HPS) complicated with respiratory failure. A 19-year-old Japanese woman with a fever, general malaise, and chest radiograph abnormalities was referred to our hospital. After admission, she developed respiratory failure with pancytopenia. A histological examination of lung and bone marrow biopsy samples revealed noncaseating granulomas without evidence of acid-fast bacilli or lymphoma. In addition, a bone marrow biopsy showed marked histiocyte hyperplasia with hemophagocytosis, and a bronchoalveolar lavage fluid culture grew Mycobacterium tuberculosis...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28626185/miliary-tuberculosis-that-developed-after-intravesical-bacillus-calmette-guerin-therapy
#2
Kyohei Kaburaki, Keishi Sugino, Muneyuki Sekiya, Yujiro Takai, Kazutoshi Shibuya, Sakae Homma
As a treatment for superficial transitional cell carcinoma, Bacillus Calmette-Guerin (BCG) intravesical instillation can rarely cause unpredictable systemic side effects. We describe a patient admitted due to continuous pyrexia and general fatigue. He was previously treated with intravesical BCG. Laboratory data indicated a hepatic disorder, and chest computed tomography revealed extensive bilateral miliary nodules. Transbronchial lung biopsy specimens showed several small noncaseating granulomas. The diagnosis was unsolved on the basis of acid fast staining, polymerase chain reaction and microbiological cultures, so we considered the possibility of BCG side effect-induced granuloma...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28610889/high-resolution-ct-findings-of-pulmonary-tuberculosis-in-liver-transplant-patients
#3
R Schuhmacher Neto, I L Giacomelli, C Schuller Nin, J da Silva Moreira, A Comaru Pasqualotto, E Marchiori, K Loureiro Irion, B Hochhegger
AIM: To assess the high-resolution computed tomography (HRCT) findings in liver transplant patients diagnosed with pulmonary Mycobacterium tuberculosis infection. MATERIALS AND METHODS: The HRCT findings from 19 patients diagnosed with pulmonary tuberculosis infection after liver transplantation were reviewed. The patients included were 12 men and seven women, age range 23-65 years; mean age 57 years. The diagnosis was established with Mycobacterium tuberculosis detection in bronchoalveolar lavage, sputum, or biopsy...
June 10, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28560175/miliary-tuberculosis-with-cerebral-liver-prostate-and-retroesophageal-involvement
#4
Raquel Goncalves, Pedro Lopes, Patrícia Mendes, João Trêpa, João Rua, Rosa Sá, Isabel Ramos, J Saraiva da Cunha
Miliary tuberculosis results from the lymphohematogenous spread of Mycobacterium tuberculosis and it is a rare form of this disease. The most affected places are the lymph nodes, pleura, and osteoarticular system, but any organ can be involved. Currently the disease is still endemic in developing countries by its close association with poor living conditions and malnutrition. Other comorbidities, particularly infection by human immunodeficiency virus (HIV), diabetes mellitus, smoking and alcoholism are of great importance in the epidemiology of this disease...
2017: IDCases
https://www.readbyqxmd.com/read/28541140/chest-ultrasound-findings-in-pulmonary-tuberculosis
#5
Paolo Agostinis, Roberto Copetti, Laura Lapini, Geraldo Badona Monteiro, Augusto N'Deque, Aldo Baritussio
In resource-limited countries, the diagnosis of pulmonary tuberculosis (TB) is based on clinical findings, chest radiography and the demonstration of acid-fast bacilli in sputum. Few data are available on the use of ultrasound (US) to diagnose pulmonary TB. Chest US was performed in patients with lung TB from a rural African setting, to look for signs of the disease and to clarify the role US may have in the diagnosis of pulmonary TB. Sixty adult patients diagnosed with lung TB underwent chest US. All patients had abnormal findings...
January 1, 2017: Tropical Doctor
https://www.readbyqxmd.com/read/28531173/a-scoring-system-to-effectively-evaluate-central-nervous-system-tuberculosis-in-patients-with-military-tuberculosis
#6
Yongjiu Xiao, Shuqing Yu, Qingliang Xue, Shan Lang, Junping Sun, Dan Feng, Jianxin Wang
There is currently no convenient way to effectively evaluate whether a miliary tuberculosis patient is complicated with central nervous system (CNS) tuberculosis. We aimed to find such a way by analyzing the clinical data of these patients. Fifty patients with confirmed miliary tuberculosis and 31 patients with confirmed miliary tuberculosis complicated with CNS tuberculosis from 2010 to 2014 were selected. Their general conditions, clinical features and laboratory tests were analyzed. Factors that were significantly different between them were chosen to performed multivariate and univariate logistic regression analyses, and factors with significant P values were used to establish a scoring system...
2017: PloS One
https://www.readbyqxmd.com/read/28503298/patterns-of-ocular-inflammation-in-patients-with-miliary-tuberculosis
#7
Salil Mehta
BACKGROUND: Ocular morbidity associated with systemic tuberculosis is common. The clinical picture varies from anterior uveitis, intermediate uveitis and posterior uveitis to even panuveitis. There is little data on the correlation between specific systemic presentations and the ocular inflammation. We conducted a retrospective review of the ocular findings in the case records of patients admitted with a diagnosis of miliary tuberculosis. These patients were then referred for a more detailed ophthalmic evaluation...
2017: F1000Research
https://www.readbyqxmd.com/read/28488945/tropical-pulmonary-eosinophilia-masquerading-as-asthma-in-a-5-year-old-girl
#8
Shivani Randev, Pankaj Kumar, Prabhjot Dhillon, Geetanjali Jindal, Vishal Guglani
Tropical pulmonary eosinophilia (TPE) is an exaggerated immunological response to filarial antigens mainly seen in adults in endemic areas and is uncommonly reported in children. The diagnosis is frequently delayed as it mimics asthma clinically, while the chest radiograph might show miliary mottling which is often confused with that in pulmonary tuberculosis. A 5-year-old girl presented with episodes of nocturnal cough, wheeze, low grade fever and breathlessness for the previous 4 months and was being treated for asthma...
May 10, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/28469917/an-uncommon-cause-of-miliary-pattern-of-pulmonary-nodules-diffuse-pulmonary-meningotheliomatosis
#9
Vivek Jayaschandran, Sandra Gjorgova-Gjeorgjievski, Haamid Siddique
Pulmonary meningothelial-like nodules are benign lesions that are often incidentally detected in surgically resected lung tissue. These nodules are usually asymptomatic and single. Rarely, they present as diffuse micronodules similar to the miliary pattern seen in tuberculosis or metastatic cancer. While diffuse meningothelial-like micronodules are usually benign, it is important to include this condition in the differential diagnosis of patients presenting with diffuse micronodules. We present the case of a 74-year-old asymptomatic female referred to the pulmonary clinic for evaluation of incidentally detected diffuse bilateral pulmonary nodules...
July 2017: Respirology Case Reports
https://www.readbyqxmd.com/read/28458316/fatal-unusual-miliary-tuberculosis-in-which-a-patient-developed-acute-respiratory-distress-syndrome-induced-by-infliximab-an-autopsy-case-report
#10
Shion Miyoshi, Jin Takasaki, Sohtaro Mine, Masanori Kono, Toru Igari, Yuichiro Takeda, Masayuki Hojo, Haruhito Sugiyama
Anti-tumor necrosis factor α (anti-TNFα) agents increase the risk of tuberculosis (TB), but cases are rarely fatal. This report concerns a patient who was undergoing treatment with infliximab and presented with acute respiratory distress syndrome due to miliary TB without a miliary shadow. The findings of a pathological autopsy revealed innumerable granulomas in the organs, and the miliary nodules in the lung consisted of more unstructured granulomas. Anti-TNFα agents are unusual in the presentation of TB...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28447377/lupus-miliaris-disseminatus-faciei-a-resistant-case-with-response-to-cyclosporine
#11
Kabir Sardana, Shikha Chugh, Rashmi Ranjan, Nita Khurana
Lupus miliaris disseminatus faciei (LMDF) is a chronic, inflammatory dermatosis of unknown etiology, characterized by multiple, monomorphic, symmetrical, reddish-brown papules over forehead, cheeks, and eyelids. Histopathology shows perifollicular epitheloid cell granuloma. Though numerous therapies, ranging from cyclines, macrolides, dapsone tranilast, isotretinoin, steroids, and tacrolimus have been tried, the results are inconsistent, except with systemic steroids. One approach is to administer therapies based on the histological findings and the corresponding mode of action of drugs, thus antibiotics and dapsone are effective in the early inflammatory stage while clofazamine can be used in the granulomatous stage of the disease...
April 26, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28427368/complications-of-miliary-tuberculosis-low-mortality-and-predictive-biomarkers-from-a-uk-cohort
#12
Jonathan Underwood, Fiona Cresswell, Alex P Salam, Alex J Keeley, Charles Cleland, Laurence John, Robert N Davidson
BACKGROUND: Untreated, miliary tuberculosis (TB) has a mortality approaching 100%. As it is uncommon there is little specific data to guide its management. We report detailed data from a UK cohort of patients with miliary tuberculosis and the associations and predictive ability of admission blood tests with clinical outcomes. METHODS: Routinely collected demographic, clinical, blood, imaging, histopathological and microbiological data were assessed for all patients with miliary TB identified from the London TB register from 2008 to 2012 from Northwest London Hospitals NHS Trust...
April 20, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28424703/immune-responses-to-bacillus-calmette-gu%C3%A3-rin-vaccination-why-do-they-fail-to-protect-against-mycobacterium-tuberculosis
#13
REVIEW
Juan I Moliva, Joanne Turner, Jordi B Torrelles
Mycobacterium tuberculosis (M.tb), the causative agent of tuberculosis (TB), is the current leading cause of death due to a single infectious organism. Although curable, the broad emergence of multi-, extensive-, extreme-, and total-drug resistant strains of M.tb has hindered eradication efforts of this pathogen. Furthermore, computational models predict a quarter of the world's population is infected with M.tb in a latent state, effectively serving as the largest reservoir for any human pathogen with the ability to cause significant morbidity and mortality...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28421876/congenital-tuberculosis-case-report-and-review-of-the-literature
#14
Ching-Wen Chang, Patricia Wanping Wu, Chih-Hua Yeh, Kin-Sun Wong, Chao-Jan Wang, Chih-Chen Chang
Congenital tuberculosis is rare, even where tuberculosis (TB) is endemic. A 14-day-old girl presented with a 3-day history of fever and respiratory distress. Her mother was diagnosed with a disseminated TB infection immediately after the delivery which was confirmed by a positive TB-polymerase chain reaction (TB-PCR) and subsequent culture from ascites and sputum. The infant was separated from her mother at birth. Her chest radiograph showed bilateral miliary nodules. Congenital TB was strongly suspected because of the symptoms, signs and maternal TB history, and was confirmed by TB-PCR and culture from the gastric lavage...
April 19, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/28420846/intrathecal-isoniazid-for-refractory-tuberculous-meningitis-with-cerebral-infarction
#15
Yuko Nakatani, Yutaka Suto, Kazuki Fukuma, Mika Yamawaki, Ryoichi Sakata, Shotaro Takahashi, Hiroyuki Nakayasu, Kenji Nakashima
A 30-year-old Vietnamese woman, about 19 weeks pregnant, was admitted for acute cerebral infarction with stenosis of the left middle cerebral artery (LMCA), tuberculous meningitis, and miliary tuberculosis. Treatment with heparin, quadruple anti-tuberculosis therapy, and dexamethasone afforded prompt symptomatic improvement. However, she delivered a stillbirth, after which there was recurrence of acute cerebral infarction with LMCA occlusion, sinus thrombosis, and cranial base inflammation. A thrice-weekly 100 mg dose of intrathecal isoniazid (INH) improved the signs of meningeal inflammation...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28420836/high-detection-rates-of-urine-mycobacterium-tuberculosis-in-patients-with-suspected-miliary-tuberculosis
#16
Toshinobu Yokoyama, Takashi Kinoshita, Masaki Okamoto, Kazuko Matsunaga, Tomoko Kamimura, Masaharu Kinoshita, Toru Rikimaru, Kazuhito Taguchi, Tomoaki Hoshino, Tomotaka Kawayama
Objective The utility of detecting Mycobacterium tuberculosis in urine samples from patients with pulmonary tuberculous with diffuse small nodular shadows (suspected miliary tuberculosis (MTB)) is still unclear in Japan. A retrospective cross-sectional study was conducted to investigate the detection rates of M. tuberculosis in urine of patients with suspected MTB. Methods Among 687 hospitalized patients with tuberculosis, 45 with culture-confirmed suspected MTB and the data of culture and polymerase chain reaction (PCR) for M...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28394836/18f-fdg-pet-ct-of-tuberculosis-meningitis-and-carotid-pseudoaneurysm
#17
Kasturi Rangan, Mudalsha Ravina, Nitin Yadav, Ajay Singh Suraj, Sanjay Gambhir
A 26-year-old woman presented with a headache, left-sided weakness of the body, and pulsatile swelling above the sternal notch. She was treated for abdominal tuberculosis in the past, two years later she developed miliary tuberculosis and was put on modified regimen of antitubercular drugs in view of drug induced hepatitis. Ultrasound neck revealed saccular aneurysm measuring 4 x 3 cm, located in between common carotid arteries with an eccentric thrombus. MRI brain revealed multiple tuberculoma with thick basal meningeal enhancement...
June 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28383840/-miliary-tuberculosis-in-a-patient-under-adalimumab
#18
A De Voeght, A-S Sauvage, M Gensburger, J-B Giot, M Moutschen
We describe a case of atypical miliary tuberculosis diagnosed by molecular testing in a patient suffering from psoriasis arthritis treated by adalimumab. Tuberculosis may have a non-classical presentation in patients under biological treatments. We briefly discuss the difficulties underlying the diagnosis and treatment of tuberculosis, especially in patients suffering from fever of unknown origin.
July 2016: Revue Médicale de Liège
https://www.readbyqxmd.com/read/28377878/miliary-tuberculosis-in-a-patient-with-tuberculous-mycotic-aneurysm-of-the-abdominal-aorta-case-report-and-review-of-the-literature
#19
Katerina Manika, Christoforos Efthymiou, Georgios Damianidis, Elisavet Zioga, Eleni Papadaki, Kalliopi Lagoudi, Ioannis Kioumis
The combination of miliary tuberculosis and tuberculous mycotic aneurysm has been described in the literature. We present the case of an 84-year-old man who was diagnosed with a mycotic aneurysm of the abdominal aorta and an adjacent soft tissue mass, after a 3- month history of fever. The patient underwent endovascular restoration of the aneurysm and was treated with broad-spectrum antibiotics. One and a half months later the fever relapsed and the chest CT scan revealed findings consistent with miliary tuberculosis and opacities of both upper lobes not present before, while the abdominal CT scan revealed an increase in the size of the para-aortic mass...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28344684/splenic-vein-thrombosis-as-a-rare-complication-of-disseminated-tuberculosis-imaging-diagnosis-and-case-report
#20
Satarupa Roy, Shuchi Bhatt, Rajesh Rawal, Anupama Tandon, Neha Meena
BACKGROUND: Venous thromboembolism is a known but rare complication associated with Mycobacterium tuberculosis infection. The reported incidence of venous thromboembolism is 1.5-3.4% of infected patients, and it occurs due to a hypercoagulable state induced by the associated inflammation. CASE REPORT: A young woman with pulmonary tuberculosis was found to have disseminated tuberculosis and a clinically unsuspected partial thrombus in the splenic vein on imaging...
2017: Polish Journal of Radiology
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