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miliary tuberculosis

Rutger Bennet, Margareta Eriksson
AIM: This study described the epidemiology and clinical features of childhood tuberculosis (TB) in Stockholm over a 45-year period, when there was a resurge of tuberculosis concomitant with increased immigration. METHODS: We describe 220 children up to the age of 16 years with active TB, seen at the Astrid Lindgren Children's Hospital from 1971-2015. The study period was divided into three 15-year periods. RESULTS: Cases increased from 10 children in 1971-1985 to 76 in 1986-2000 and 134 in 2001-2015, with overall incidence increasing from <1 to four per 100,000...
October 14, 2016: Acta Paediatrica
Bharathkanth Reddy M
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Kanishka Jain
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Takuma Tsuzuki Wada, Kojiro Sato, Toshihide Mimura
We encountered a case of a middle-aged woman with systemic lupus erythematosus. As the patient had progressive peripheral neuropathy including foot drop, we intended to treat her with intensive immunosuppressive therapy as soon as possible. Pretreatment assessment, however, revealed multiple nodular lesions in the lungs and bones, suggesting disseminated tumor metastasis or miliary tuberculosis. To our surprise, gallium and bone scintigraphy as well as cytodiagnosis revealed no sign of malignancy or infection, leading us to suspect the presence of another multisystem disorder...
March 2016: Eur J Rheumatol
Yesim Ozguler, Gulen Hatemi, Serdal Ugurlu, Emire Seyahi, Melike Melikoglu, Sermin Borekci, Ersan Atahan, Gul Ongen, Vedat Hamuryudan
The use of anti-TNF agents is associated with an increased risk of tuberculosis (TB) and anti-TNF agents are stopped when active TB develops. However, discontinuation of treatment can result in flare of the underlying disease. The charts of 22 patients who developed active TB among a cohort of 2754 patients using anti-TNF agents between 2001 and 2013 were reviewed retrospectively. Patients restarting biologics during further follow-up were identified. One patient with miliary TB died within 1 month. A biologic agent was restarted in 16 of the remaining 21 patients (76 %)...
October 3, 2016: Rheumatology International
Amar Singh, Anant Mohan, Aprajit B Dey, Dipendra K Mitra
BACKGROUND: Optimal T cell activation is vital for the successful resolution of microbial infections. Programmed death-1 (PD-1) is key immune checkpoint receptor expressed by activated T cells. Aberrant/excessive inhibition mediated by PD-1 may impair host immunity to M. tuberculosis infection, leading to disseminated disease like miliary tuberculosis (MTB). PD-1 mediated inhibition of T cells in pulmonary tuberculosis and TB pleurisy is reported. However, their role in MTB, particularly at the pathologic sites remains to be addressed...
September 26, 2016: Clinical and Experimental Immunology
B Tiri, L M Saraca, E Luciano, F R Burkert, S Cappanera, E Cenci, D Francisci
The extra-pulmonary tuberculosis (TB) constitutes to about 20% of all TB cases. Among extra-pulmonary form, splenic TB is very rare clinical condition especially as initial manifestation in a developed country. Diagnosis of splenic TB is challenging because it presents no specific symptoms or typical imaging findings and microbiological confirmation is not straight forward. We describe the case of a 55 year old Italian female with advanced HIV infection whose first AIDS clinical manifestation was a TB splenic abscess...
2016: IDCases
Jaideep Dey, Hitender Gautam, Shwetha Venugopal, Chhavi Porwal, Bijay Ranjan Mirdha, Naresh Gupta, Urvashi B Singh
Background. Tuberculosis of the liver without active pulmonary or miliary tuberculosis is considered as an uncommon diagnosis. The aim of the present study was to determine the etiological role of tuberculosis in adult patients presenting with features of liver abscess. Methods. A total of 40 patients with liver abscess were included in the study. The liver abscess aspirate was subjected to microscopy, culture, and polymerase chain reaction to determine the role of tuberculosis as an etiological factor in liver abscess...
2016: Tuberculosis Research and Treatment
Sara C Auld, Scott H Lee, Eleanor S Click, Roque Miramontes, Cheryl L Day, Neel R Gandhi, Charles M Heilig
RATIONALE: The interferon gamma release assays and tuberculin skin tests are used to support the diagnosis of both latent and active tuberculosis. However, we previously demonstrated that a negative tuberculin test in active tuberculosis is associated with disseminated disease and death. It is unknown whether the same associations exist for interferon gamma release assays. OBJECTIVES: To determine the association between these tests and site of tuberculosis and death among persons with active tuberculosis...
August 31, 2016: Annals of the American Thoracic Society
Bandar Al-Ghamdi, Hassan El Widaa, Maie Al Shahid, Mohammed Aladmawi, Jawaher Alotaibi, Aly Al Sanei, Magid Halim
BACKGROUND: Infection of cardiac implantable electronic devices is a serious cardiovascular disease and it is associated with a high mortality. Mycobacterium species may rarely cause cardiac implantable electronic devices infection. CASE PRESENTATION: We are reporting a case of miliary tuberculosis in an Arab patient with dilated cardiomyopathy and a cardiac resynchronization therapy-defibrillator device that was complicated with infection of his cardiac resynchronization therapy-defibrillator device...
2016: BMC Research Notes
Begoña Carazo Gallego, David Moreno-Pérez, Esmeralda Nuñez Cuadros, Alba Mesa Fernandez, María Martin Cantero, Pablo Obando Pacheco, Antonio Urda Cardona
BACKGROUND: A paradoxical reaction (PR) during anti-tuberculosis treatment is a phenomenon that is poorly studied in immunocompetent children. It is defined as a clinical or radiological worsening of pre-existing tuberculosis (TB) disease. METHODS: A retrospective descriptive study of children younger than 14 years of age was performed; these children developed PR during the years 2009 to 2014, following a diagnosis of TB. Demographic characteristics, microbiological results, treatment and outcome data were collected...
August 17, 2016: International Journal of Infectious Diseases: IJID
(no author information available yet)
In 2014, 49 pediatric tuberculosis (TB) patients aged 0-14 years were newly notified in Japan, with a notification rate of 0.30 per 100,000 population. Since 2006, the number of pediatric TB patients notified each year has been less than 100. Of the 49 patients, 17 (34.7%) were aged 0-4 years, 15 (30.6%) were 5-9 years, and 17 (34.7%) were 10-14 years. Until recently, the proportion of those aged 0-4 years was higher than those aged 10-14 years, but this year the proportions have become equal. Of these 49, five had meningeal TB and two had miliary TB...
April 2016: Kekkaku: [Tuberculosis]
Cihadiye Elif Öztürk, İdris Şahin, Şükrü Öksüz, Nida Kılıç, Özge Kılınçel, Leyla Aydın, Dursun Atik, Emine Afşin
Throughout the history of mankind, tuberculosis (TB) has caused serious illness and still continues to do so. Archaeobiological studies indicated that TB in humans dates back to 4000-8000 BC, and cases were shown to be due to Mycobacterium bovis subsp.bovis rather than Mycobacterium tuberculosis. Moreover, this situation was thought to begin with domestication of animals, consumption of their milk, and living together in the same environment with them. Over time, with the consumption of boiled milk and with the establishment of separate animal shelters, M...
July 2016: Mikrobiyoloji Bülteni
Jamilah Meghji, Hope Simpson, S Bertel Squire, Kevin Mortimer
BACKGROUND: Tuberculosis is an important risk factor for chronic respiratory disease in resource poor settings. The persistence of abnormal spirometry and symptoms after treatment are well described, but the structural abnormalities underlying these changes remain poorly defined, limiting our ability to phenotype post-TB lung disease in to meaningful categories for clinical management, prognostication, and ongoing research. The relationship between post-TB lung damage and patient-centred outcomes including functional impairment, respiratory symptoms, and health related quality of life also remains unclear...
2016: PloS One
Resat Ozaras, Betul Vatankulu, Bilgul Mete, Bahar Kacmaz, Metin Halac
No abstract text is available yet for this article.
July 19, 2016: QJM: Monthly Journal of the Association of Physicians
Mahmood Dhahir Al-Mendalawi
No abstract text is available yet for this article.
May 2016: Oman Journal of Ophthalmology
Hiromitsu Shimada, Yusuke Nakamura, Tomoko Saito-Shono, Kazushi Ishikawa, Haruto Nishida, Shigeo Yokoyama, Kazufumi Hiramatsu, Kazue Nakanaga, Norihisa Ishii, Shuichi Takikawa, Takashi Sakai, Naoko Takeo, Sakuhei Fujiwara, Yutaka Hatano
No abstract text is available yet for this article.
July 5, 2016: European Journal of Dermatology: EJD
Priscilla S Freire, João D Montoni, Aline S M Ribeiro, Heloísa H Marques, Thais Mauad, Clovis A Silva
INTRODUCTION: One of the main issues in juvenile systemic lupus erythematosus (JSLE) patients is infection, such as tuberculosis (TB). Of note, SLE patients are susceptible to pulmonary and extrapulmonary TB. However, to our knowledge, this contagious disease was rarely reported in pediatric lupus population, particularly diffuse or miliary TB. Therefore, from January 1983 to December 2011, 5,635 patients were followed-up at our Pediatric Rheumatology Unit and 285 (5%) of them met the American College of Rheumatology classification criteria for SLE...
May 2016: Revista Brasileira de Reumatologia
(no author information available yet)
This brief is the first of a series of documents based on the Tuberculosis Annual Report 2014. It includes a summary of tuberculosis (TB) statistics, including data on foreign-born TB patients notified and registered in Japan in 2014. For the first time, the number of newly notified cases (all forms of TB) fell below 20,000. In 2014, a total of 19,615 patients were notified, a rate of 15.4 per 100,000 population The number of sputum-smear positive pulmonary. TB patients notified was 7,651, a rate of 6.0 per 100,000 population...
February 2016: Kekkaku: [Tuberculosis]
Keigo Koda, Yasunori Enomoto, Minako Omae, Daisuke Akahori, Takefumi Abe, Hirotsugu Hasegawa, Takashi Matsui, Koshi Yokomura, Takafumi Suda
An 86-year-old woman with severe dementia had been treated with oral prednisolone at 2 mg/day for autoimmune bullous dermatosis for several years. One year ago, she referred to our hospital due to an ulcerative skin lesion over the right tibial tuberosity. The lesion was treated by an iodine-containing ointment, but did not heal. Subsequently, a new skin lesion appeared in the right popliteal fossa. One month ago, the patient had increased sputum production that was accompanied by fever, anorexia, and dyspnea; consequently, she visited our department...
February 2016: Kekkaku: [Tuberculosis]
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