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Stanniocalcin 1

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https://www.readbyqxmd.com/read/29065179/comparative-proteome-and-peptidome-analysis-of-the-cephalic-fluid-secreted-by-arapaima-gigas-teleostei-osteoglossidae-during-and-outside-parental-care
#1
COMPARATIVE STUDY
Lucas S Torati, Hervé Migaud, Mary K Doherty, Justyna Siwy, Willian Mullen, Pedro E C Mesquita, Amaya Albalat
Parental investment in Arapaima gigas includes nest building and guarding, followed by a care provision when a cephalic fluid is released from the parents' head to the offspring. This fluid has presumably important functions for the offspring but so far its composition has not been characterised. In this study the proteome and peptidome of the cephalic secretion was studied in parental and non-parental fish using capillary electrophoresis coupled to mass spectrometry (CE-MS) and GeLC-MS/MS analyses. Multiple comparisons revealed 28 peptides were significantly different between males and parental males (PC-males), 126 between females and parental females (PC-females), 51 between males and females and 9 between PC-males and PC-females...
2017: PloS One
https://www.readbyqxmd.com/read/28974356/long-term-photoreceptor-rescue-in-two-rodent-models-of-retinitis-pigmentosa-by-adeno-associated-virus-delivery-of-stanniocalcin-1
#2
Gavin W Roddy, Douglas Yasumura, Michael T Matthes, Marcel V Alavi, Sanford L Boye, Robert H Rosa, Michael P Fautsch, William W Hauswirth, Matthew M LaVail
Retinal degenerations, including age-related macular degeneration and the retinitis pigmentosa family of diseases, are among the leading causes of legal blindness in the United States. We previously found that Stanniocalcin-1 (STC-1) reduced photoreceptor loss in the S334ter-3 and Royal College of Surgeons rat models of retinal degeneration. The results were attributed in part to a reduction in oxidative stress. Herein, we tested the hypothesis that long-term delivery of STC-1 would provide therapeutic rescue in more chronic models of retinal degeneration...
September 30, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28945869/effects-of-prednisolone-on-serum-and-tissue-fluid-igf-i-receptor-activation-and-post-receptor-signaling-in-humans
#3
Nilani Ramshanker, Maiken Aagaard, Rikke Hjortebjerg, Thomas Schmidt Voss, Niels Møller, Jens Otto Lunde Jørgensen, Niels Jessen, Peter Bjerring, Nils Erik Magnusson, Mette Bjerre, Claus Oxvig, Jan Frystyk
Context: Short-term glucocorticoid exposure increases serum insulinlike growth factor I (IGF-I) concentrations but antagonizes IGF-I tissue signaling. The underlying mechanisms remain unknown. Objective: To identify at which levels glucocorticoid inhibits IGF-I signaling. Design and Methods: Nineteen healthy males received prednisolone (37.5 mg/d) and placebo for 5 days in a randomized, double-blinded, placebo-controlled crossover study. Serum was collected on days 1, 3, and 5, and abdominal skin suction blister fluid (SBF; ~interstitial fluid) was taken on day 5 (n = 9) together with muscle biopsy specimens (n = 19)...
November 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28911149/insulin-like-growth-factor-bioactivity-stanniocalcin-2-pregnancy-associated-plasma-protein-a-and-igf-binding-protein-4-in-pleural-fluid-and-serum-from-patients-with-pulmonary-disease
#4
COMPARATIVE STUDY
Ulrick Skipper Espelund, Mette Bjerre, Rikke Hjortebjerg, Torben Riis Rasmussen, Anders Lundby, Andreas Hoeflich, Birgitte Holst Folkersen, Claus Oxvig, Jan Frystyk
Context: Members of the insulin-like growth factor (IGF) system are primarily produced in the liver and secreted into the circulation, but they are also produced, recruited, and activated locally in tissues. Objective: To compare activity and concentrations of IGF system components in pleural fluid and blood. Design: Pathological pleural fluid, secondary to lung cancer or nonmalignant disease, and matching blood samples were collected from 24 patients ages 66...
September 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28801361/one-level-up-abnormal-proteolytic-regulation-of-igf-activity-plays-a-role-in-human-pathophysiology
#5
REVIEW
Jesús Argente, Julie A Chowen, Luis A Pérez-Jurado, Jan Frystyk, Claus Oxvig
The discovery of a mutation in a specific gene can be very important for determining the pathophysiology underlying the disease of a patient and may also help to decide the best treatment protocol on an individual basis. However, sometimes the discovery of mutations in new proteins advances our comprehension in a more widespread manner. The growth hormone (GH)/insulin-like growth factor (IGF)-1 axis is fundamental for systemic growth, but is also involved in many other important processes. Our understanding of this system in physiology and pathophysiology has advanced throughout the years with each discovery of mutations in members of this axis...
October 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28688970/secretory-stanniocalcin-1-promotes-metastasis-of-hepatocellular-carcinoma-through-activation-of-jnk-signaling-pathway
#6
Kristy Kwan-Shuen Chan, Carmen Oi-Ning Leung, Carmen Chak-Lui Wong, Daniel Wai-Hung Ho, Kenneth Siu-Ho Chok, Ching-Lung Lai, Irene Oi-Lin Ng, Regina Cheuk-Lam Lo
The hypoxic microenvironment is well-characterized in hepatocellular carcinoma (HCC). Delineation of hypoxia-responsive events is an integral part to understand the pathogenesis of HCC. We studied the functional role and clinical relevance of Stanniocalcin 1 (STC1), a hypoxia-induced molecular target, in HCC. In our clinical cohort, STC1 transcript was up-regulated in HCC tumor tissues. Moreover, STC1 protein was detected in the sera of HCC patients. A higher serum STC1 level was correlated with larger tumor size and poorer 5-year disease-free survival...
September 10, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28665755/depletion-of-carbonic-anhydrase-ix-abrogates-hypoxia-induced-overexpression-of-stanniocalcin-1-in-triple-negative-breast-cancer-cells
#7
Elīna Zandberga, Pawel Zayakin, Artūrs Ābols, Dārta Pūpola, Pēteris Trapencieris, Aija Linē
Carbonic anhydrase IX (CAIX) is a pH-regulating enzyme that plays a key role in maintaining an alkaline intracellular pH under hypoxic conditions. It is overexpressed in a variety of solid cancers, including breast cancer (BC), and has been implicated in the migration, invasion and stemness of breast cancer cells. Therefore, CAIX recently emerged as a novel therapeutic target for the treatment of BC. To gain an insight into the mechanism of action of CAIX inhibitors, we investigated the impact of CAIX knock-down on the transcriptional response to hypoxia in 2 BC cell lines - MCF7 and MDA-MB-231, by performing a global gene expression analysis...
August 3, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28655163/microrna-21a-5p-pdcd4-axis-regulates-mesenchymal-stem-cell-induced-neuroprotection-in-acute-glaucoma
#8
Wenru Su, Zuohong Li, Y Jia, Yingting Zhu, Wenjia Cai, Peixing Wan, Yingying Zhang, Song Guo Zheng, Yehong Zhuo
Mesenchymal stem cells (MSCs) have been demonstrated to have promising therapeutic benefits for a variety of neurological diseases; however, the underlying mechanisms are poorly understood. Here, we showed that intravitreal infusion of MSCs promoted retinal ganglion cell (RGC) survival in a mouse model of acute glaucoma, with significant inhibition of microglial activation, production of TNF-α, IL-1β, and reactive oxygen species, as well as caspase-8 and caspase-3 activation. In vitro, MSCs inhibited both caspase-8-mediated RGC apoptosis and microglial activation, partly via the action of stanniocalcin 1 (STC1)...
August 1, 2017: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/28538979/stanniocalcin-1-is-an-ocular-hypotensive-agent-and-a-downstream-effector-molecule-that-is-necessary-for-the-intraocular-pressure-lowering-effects-of-latanoprost
#9
Gavin W Roddy, Kimberly B Viker, Nelson S Winkler, Cindy K Bahler, Bradley H Holman, David Sheikh-Hamad, Uttio Roy Chowdhury, W Daniel Stamer, Michael P Fautsch
Purpose: To identify downstream signaling molecules through which intraocular pressure (IOP) is lowered following treatment with the prostaglandin analog latanoprost. Methods: Total RNA and protein isolated from primary human Schlemm's canal cells (n = 3) treated with latanoprost (free acid; 100 nM) were processed for quantitative PCR and Western blot analysis. IOP was evaluated in stanniocalcin-1 (STC-1-/-) and wild-type mice following treatment with latanoprost or Rho kinase inhibitor Y27632...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28435144/effects-of-stanniocalcin-1-on-glucose-flux-in-rat-brown-adipose-tissue
#10
Aline G Cozer, Márcia Trapp, Tiago L Martins, Luciano Stürmer De Fraga, Claudia Vieira Marques, Jorge Felipe A Model, Vanessa Schein, Luiz Carlos Kucharski, Roselis S M Da Silva
The present work assesses in vitro the role of human Stanniocalcin 1 (hSTC-1) in (14)C-glucose metabolism in brown adipose tissue (BAT) from fed rat. In the fed state, hSTC-1 decreases the incorporation of (14)C from glucose into lipids in the rat BAT. The data support the hypothesis that the capacity of the glycerol-3-phosphate (G3P)-generating pathway (glycolysis) from glucose is regulated by hSTC-1, decreasing the adequate supply of G3P needed for fatty acid esterification and triacylglycerol (TG) storage in BAT...
July 2017: Biochimie
https://www.readbyqxmd.com/read/28350121/stanniocalcin-1-promotes-cell-proliferation-via-cyclin%C3%A2-e1-cyclin%C3%A2-dependent-kinase-2-in-human-prostate-carcinoma
#11
Yao Bai, Yichen Xiao, Yuanqing Dai, Xiong Chen, Dongjie Li, Xinji Tan, Xiaobo Zhang
Stanniocalcin 1 (STC1) is a glycoprotein hormone that is involved in calcium/phosphate homeostasis. Increasing evidence suggests that STC1 is involved in carcinogenesis; however, few studies have defined the mechanisms and functional roles of STC1 activity in prostate carcinogenesis. In the present study, MTT, flow cytometry and colony formation assays, and small interfering RNA (siRNA) and overexpression in multiple cell lines were used to investigate the function of STC1 in prostate carcinoma in vivo and in vivo...
April 2017: Oncology Reports
https://www.readbyqxmd.com/read/28323996/molecular-physiology-of-the-hypocalcemic-action-of-fibroblast-growth-factor-23-in-zebrafish-danio-rerio
#12
Chia-Hao Lin, Huei-Jyun Hu, Pung-Pung Hwang
Fibroblast growth factor 23 (FGF23), a hormone required for phosphorus metabolism, was recently proposed to act on Ca2+ uptake; however, the available evidence of how FGF23 controls the body fluid Ca2+ homeostasis needs to be further clarified. The use of zebrafish as a model system revealed that FGF23 is specifically expressed in the corpuscles of Stannius (CS), an organ involved in Ca2+ homeostasis in fish, and that its expression is stimulated by ambient water with a high Ca2+ level. The overexpression of FGF23 inhibited Ca2+ uptake by downregulating the messenger RNA (mRNA) expression of epithelium calcium channel...
May 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28212442/ecto-5-nucleotidase-cd73-nt5e-vitamin-d-receptor-and-fgf23-gene-polymorphisms-may-play-a-role-in-the-development-of-calcific-uremic-arteriolopathy-in-dialysis-patients-data-from-the-german-calciphylaxis-registry
#13
Hansjörg Rothe, Vincent Brandenburg, Margot Haun, Barbara Kollerits, Florian Kronenberg, Markus Ketteler, Christoph Wanner
INTRODUCTION: Calciphylaxis/calcific uremic arteriolopathy affects mainly end-stage kidney disease patients but is also associated with malignant disorders such as myeloma, melanoma and breast cancer. Genetic risk factors of calciphylaxis have never been studied before. METHODS: We investigated 10 target genes using a tagging SNP approach: the genes encoding CD73/ ecto-5'-nucleotidase (purinergic pathway), Matrix Gla protein, Fetuin A, Bone Gla protein, VKORC1 (all related to intrinsic calcification inhibition), calcium-sensing receptor, FGF23, Klotho, vitamin D receptor, stanniocalcin 1 (all related to CKD-MBD)...
2017: PloS One
https://www.readbyqxmd.com/read/27878259/stanniocalcin-2-improved-osteoblast-differentiation-via-phosphorylation-of-erk
#14
Juan Zhou, Yinghua Li, Lina Yang, Yougen Wu, Yunjiao Zhou, Yunqing Cui, Gong Yang, Yang Hong
Mammalian stanniocalcin 2 (STC2) is a glycoprotein hormone with multiple functions. The present study determined the importance of STC2 in osteoblast differentiation. It was revealed that the expression of STC2 was increased during the differentiation of MC3T3-E1 cells to osteoblasts and that knockdown of STC2 reduced osteoblast differentiation and mineralization, whereas STC2 overexpression increased differentiation and mineralization. Knockdown of STC2 downregulated the expression of osteoblast-associated genes, including runt‑related transcription factor 2, collagen type I α 1 chain, osterix and osteocalcin...
December 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27730346/stanniocalcin-1-enhances-carbon-flux-from-glucose-to-lipids-in-white-retroperitoneal-adipose-tissue-in-the-fed-rat
#15
Aline G Cozer, Márcia Trapp, Claudia Vieira Marques, Tiago L Martins, Jorge Felipe A Model, Vanessa Schein, Luiz Carlos Kucharski, Roselis S M Da Silva
The present work assesses in vitro the role of human Stanniocalcin 1 (hSTC-1) in glucose metabolism in white retroperitoneal adipose tissue (WRAT) from fed rat. In the fed state, hSTC1 increases the incorporation of (14)C from glucose into lipids in the rat WRAT. The increase in lipogenesis capacity supports the hypothesis that the activity of the glycerol-3-phosphate-generating pathway (glycolysis) from glucose is regulated by hSTC-1. The effect of hSTC-1 on de novo fatty acid synthesis and on glucose oxidation in WRAT is supported by an 85 % increase in (14)CO2 production from (14)C-glucose...
November 2016: Lipids
https://www.readbyqxmd.com/read/27646979/cerebrospinal-fluid-stanniocalcin-1-as-a-biomarker-for-alzheimer-s-disease-and-other-neurodegenerative-disorders
#16
Pashtun Shahim, Kaj Blennow, Per Johansson, Johan Svensson, Simone Lista, Harald Hampel, Leif Christer Andersson, Henrik Zetterberg
Stanniocalcin-1 (STC-1) is a nerve cell-enriched protein involved in intracellular calcium homeostasis regulation. Changes in calcium regulation are hypothesized to play a role in the pathophysiology of Alzheimer's disease (AD). The expression of STC-1 increases in response to ischemic stroke, but whether it is altered in neurodegenerative disorder, particularly Alzheimer's disease (AD), has not been investigated before. We measured STC-1 in cerebrospinal fluid (CSF) samples from a total of 163 individuals including AD, prodromal AD (pAD), mixed AD, stable mild cognitive impairment (sMCI), and diagnoses of other dementia than AD, as well as cognitively normal controls (CNC) enrolled at academic centers in France and Sweden...
March 2017: Neuromolecular Medicine
https://www.readbyqxmd.com/read/27603899/stanniocalcin-1-hormone-in-nonpreeclamptic-and-preeclamptic-pregnancy-clinical-life-style-and-genetic-modulators
#17
Peeter Juhanson, Kristiina Rull, Triin Kikas, Hannele Laivuori, Pille Vaas, Eero Kajantie, Seppo Heinonen, Maris Laan
CONTEXT AND OBJECTIVES: The study represents the first comprehensive analysis of Stanniocalcin-1 (STC1) hormone in human pregnancy, assessing clinical, lifestyle, and genetic determinants of circulating STC1 at term. DESIGN, SETTING, AND PARTICIPANTS: Participants included women with (n = 50) and without (n = 316) preeclampsia (PE) at delivery, recruited in the REPROgrammed fetal and/or maternal METAbolism (REPROMETA) study (2006-2011, Estonia). Genetic association analysis combined PE cases (n = 597) and controls (n = 623) from the REPROMETA and Finnish Genetics of Preeclampsia Consortium (2008-2011) studies...
December 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27560636/effect-of-hypoxia-on-the-expression-of-genes-encoding-insulin-like-growth-factors-and-some-related-proteins-in-u87-glioma-cells-without-ire1-function
#18
Dmytro O Minchenko, A P Kharkova, O V Halkin, L L Karbovskyi, O H Minchenko
OBJECTIVE: The aim of the present study was to investigate the effect of hypoxia on the expression of genes encoding insulin-like growth factors (IGF1 and IGF2), their receptor (IGF1R), binding protein-4 (IGFBP4), and stanniocalcin 2 (STC2) in U87 glioma cells in relation to inhibition of endoplasmic reticulum stress signaling mediated by IRE1 (inositol requiring enzyme 1) for evaluation of their possible significance in the control of tumor growth. METHODS: The expression of IGF1, IGF2, IGF1R, IGFBP4, and STC2 genes in U87 glioma cells transfected by empty vector pcDNA3...
April 2016: Endocrine Regulations
https://www.readbyqxmd.com/read/27554927/insights-into-molecular-and-cellular-mechanisms-of-hormonal-actions-on-fish-ion-regulation-derived-from-the-zebrafish-model
#19
Ying-Jey Guh, Pung-Pung Hwang
Fish have sophisticated mechanisms of ionic and acid-base regulation for maintaining body fluid homeostasis. Many hormones have been proposed to control the ionic and acid-base regulation mechanisms in fishes; however, lots of the proposed actions lack convincing cellular/molecular evidence. With the advantages of available genetic databases and molecular manipulation techniques, zebrafish has become an emerging model for research into ion transport physiology and functional regulation. Different types of ionocytes were found to transport ions through various sets of ion transporters, and the molecular mechanisms of ionocyte proliferation and differentiation have also been dissected, providing a competent platform with which to precisely study the ion transport pathways and ionocytes targeted by hormones, including isotocin, prolactin, cortisol, stanniocalcin-1, calcitonin, endothelin-1, vitamin D, parathyroid hormone 1, catecholamines, the renin-angiotensin-system, estrogen-related receptor α, and calcitonin gene-related peptide, which have been demonstrated to positively or negatively regulate ion transport through specific receptors at different molecular levels (transcriptional, translational, or posttranslational) or at different developmental stages of ionocytes (proliferation or differentiation)...
September 15, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/27469269/stanniocalcin-1-attenuates-ischemic-cardiac-injury-and-response-of-differentiating-monocytes-macrophages-to-inflammatory-stimuli
#20
Arezoo Mohammadipoor, Ryang Hwa Lee, Darwin J Prockop, Thomas J Bartosh
Stanniocalcin-1 (STC-1) is a multifunctional glycoprotein with antioxidant and anti-inflammatory properties. Ischemic myocardial necrosis generates "danger" signals that perpetuate detrimental inflammatory reactions often involving monocyte recruitment and their subsequent differentiation into proinflammatory macrophages. Therefore, we evaluated the effects of recombinant STC-1 (rSTC-1) on monocyte phenotype and in a mouse model of myocardial infarction. Using an established protocol to differentiate human monocytes into macrophages, we demonstrated that rSTC-1 did not alter morphology of the differentiated cells, toll-like receptor (TLR) 4 expression, or expression of the myeloid cell marker CD11b...
November 2016: Translational Research: the Journal of Laboratory and Clinical Medicine
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