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Stanniocalcin 1

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https://www.readbyqxmd.com/read/27878259/stanniocalcin-2-improved-osteoblast-differentiation-via-phosphorylation-of-erk
#1
Juan Zhou, Yinghua Li, Lina Yang, Yougen Wu, Yunjiao Zhou, Yunqing Cui, Gong Yang, Yang Hong
Mammalian stanniocalcin 2 (STC2) is a glycoprotein hormone with multiple functions. The present study determined the importance of STC2 in osteoblast differentiation. It was revealed that the expression of STC2 was increased during the differentiation of MC3T3-E1 cells to osteoblasts and that knockdown of STC2 reduced osteoblast differentiation and mineralization, whereas STC2 overexpression increased differentiation and mineralization. Knockdown of STC2 downregulated the expression of osteoblast-associated genes, including runt‑related transcription factor 2, collagen type I α 1 chain, osterix and osteocalcin...
November 16, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27730346/stanniocalcin-1-enhances-carbon-flux-from-glucose-to-lipids-in-white-retroperitoneal-adipose-tissue-in-the-fed-rat
#2
Aline G Cozer, Márcia Trapp, Claudia Vieira Marques, Tiago L Martins, Jorge Felipe A Model, Vanessa Schein, Luiz Carlos Kucharski, Roselis S M Da Silva
The present work assesses in vitro the role of human Stanniocalcin 1 (hSTC-1) in glucose metabolism in white retroperitoneal adipose tissue (WRAT) from fed rat. In the fed state, hSTC1 increases the incorporation of (14)C from glucose into lipids in the rat WRAT. The increase in lipogenesis capacity supports the hypothesis that the activity of the glycerol-3-phosphate-generating pathway (glycolysis) from glucose is regulated by hSTC-1. The effect of hSTC-1 on de novo fatty acid synthesis and on glucose oxidation in WRAT is supported by an 85 % increase in (14)CO2 production from (14)C-glucose...
October 11, 2016: Lipids
https://www.readbyqxmd.com/read/27646979/cerebrospinal-fluid-stanniocalcin-1-as-a-biomarker-for-alzheimer-s-disease-and-other-neurodegenerative-disorders
#3
Pashtun Shahim, Kaj Blennow, Per Johansson, Johan Svensson, Simone Lista, Harald Hampel, Leif Christer Andersson, Henrik Zetterberg
Stanniocalcin-1 (STC-1) is a nerve cell-enriched protein involved in intracellular calcium homeostasis regulation. Changes in calcium regulation are hypothesized to play a role in the pathophysiology of Alzheimer's disease (AD). The expression of STC-1 increases in response to ischemic stroke, but whether it is altered in neurodegenerative disorder, particularly Alzheimer's disease (AD), has not been investigated before. We measured STC-1 in cerebrospinal fluid (CSF) samples from a total of 163 individuals including AD, prodromal AD (pAD), mixed AD, stable mild cognitive impairment (sMCI), and diagnoses of other dementia than AD, as well as cognitively normal controls (CNC) enrolled at academic centers in France and Sweden...
September 19, 2016: Neuromolecular Medicine
https://www.readbyqxmd.com/read/27603899/stanniocalcin-1-hormone-in-non-preeclamptic-and-preeclamptic-pregnancy-clinical-life-style-and-genetic-modulators
#4
Peeter Juhanson, Kristiina Rull, Triin Kikas, Hannele Laivuori, Pille Vaas, Eero Kajantie, Seppo Heinonen, Maris Laan
: Context, Objectives: The study represents the first comprehensive analysis of Stanniocalcin 1 (STC1) hormone in human pregnancy, assessing clinical, life-style and genetic determinants of circulating STC1 at term. DESIGN, SETTING, PARTICIPANTS: Participants included women with (n=50) and without (n=316) preeclampsia (PE) at delivery, recruited in the REPROgrammed fetal and/or maternal METAbolism study (REPROMETA; 2006-2011, Estonia). Genetic association analysis combined PE cases (n=597) and controls (n=623) from the REPROMETA and FINNPEC (the Finnish Genetics of Preeclampsia Consortium; 2008-2011) studies...
September 7, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27560636/effect-of-hypoxia-on-the-expression-of-genes-encoding-insulin-like-growth-factors-and-some-related-proteins-in-u87-glioma-cells-without-ire1-function
#5
Dmytro O Minchenko, A P Kharkova, O V Halkin, L L Karbovskyi, O H Minchenko
OBJECTIVE: The aim of the present study was to investigate the effect of hypoxia on the expression of genes encoding insulin-like growth factors (IGF1 and IGF2), their receptor (IGF1R), binding protein-4 (IGFBP4), and stanniocalcin 2 (STC2) in U87 glioma cells in relation to inhibition of endoplasmic reticulum stress signaling mediated by IRE1 (inositol requiring enzyme 1) for evaluation of their possible significance in the control of tumor growth. METHODS: The expression of IGF1, IGF2, IGF1R, IGFBP4, and STC2 genes in U87 glioma cells transfected by empty vector pcDNA3...
April 2016: Endocrine Regulations
https://www.readbyqxmd.com/read/27554927/insights-into-molecular-and-cellular-mechanisms-of-hormonal-actions-on-fish-ion-regulation-derived-from-the-zebrafish-model
#6
Ying-Jey Guh, Pung-Pung Hwang
Fish have sophisticated mechanisms of ionic and acid-base regulation for maintaining body fluid homeostasis. Many hormones have been proposed to control the ionic and acid-base regulation mechanisms in fishes; however, lots of the proposed actions lack convincing cellularr/molecular evidence. With the advantages of available genetic databases and molecular manipulation techniques, zebrafish has become an emerging model for research into ion transport physiology and functional regulation. Different types of ionocytes were found to transport ions through various sets of ion transporters, and the molecular mechanisms of ionocyte proliferation and differentiation have also been dissected, providing a competent platform with which to precisely study the ion transport pathways and ionocytes targeted by hormones, including isotocin, prolactin, cortisol, stanniocalcin-1, calcitonin, endothelin-1, vitamin D, parathyorid hormone 1, catecholamines, the renin-angiotensin-system, estrogen-related receptor α, and calcitonin gene-related peptide, which have been demonstrated to positively or negatively regulate ion transport through specific receptors at different molecular levels (transcriptional, translational, or posttranslational) or at different developmental stages of ionocytes (proliferation or differentiation)...
August 20, 2016: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/27469269/stanniocalcin-1-attenuates-ischemic-cardiac-injury-and-response-of-differentiating-monocytes-macrophages-to-inflammatory-stimuli
#7
Arezoo Mohammadipoor, Ryang Hwa Lee, Darwin J Prockop, Thomas J Bartosh
Stanniocalcin-1 (STC-1) is a multifunctional glycoprotein with antioxidant and anti-inflammatory properties. Ischemic myocardial necrosis generates "danger" signals that perpetuate detrimental inflammatory reactions often involving monocyte recruitment and their subsequent differentiation into proinflammatory macrophages. Therefore, we evaluated the effects of recombinant STC-1 (rSTC-1) on monocyte phenotype and in a mouse model of myocardial infarction. Using an established protocol to differentiate human monocytes into macrophages, we demonstrated that rSTC-1 did not alter morphology of the differentiated cells, toll-like receptor (TLR) 4 expression, or expression of the myeloid cell marker CD11b...
November 2016: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/27461417/stc-1-expression-is-upregulated-through-an-akt-nf-%C3%AE%C2%BAb-dependent-pathway-in-triple-negative-breast-cancer-cells
#8
Myeongjin Jeon, Jeonghun Han, Seok Jin Nam, Jeong Eon Lee, Sangmin Kim
Stanniocalcin-1 (STC-1) is a secreted glycoprotein and its expression is strongly correlated with cancer development. However, regulatory mechanism of STC-1 expression in breast cancer cells is not clear. In the present study, we investigated whether STC-1 acts as a prognostic factor in TNBC patients and the regulation of STC-1 expression in breast cancer cells. Basal levels of STC-1 were significantly higher in TNBC cells than in non-TNBC cells. Induction of STC-1 expression was also associated with poor relapse-free survival of TNBC patients...
September 2016: Oncology Reports
https://www.readbyqxmd.com/read/27459971/elevated-stc%C3%A2-1-augments-the-invasiveness-of-triple%C3%A2-negative-breast-cancer-cells-through-activation-of-the-jnk-c%C3%A2-jun-signaling-pathway
#9
Jeonghun Han, Myeongjin Jeon, Incheol Shin, Sangmin Kim
Stanniocalcin‑1 (STC‑1), a secreted glycoprotein, is highly expressed in a variety of human malignancies. However, the role of STC‑1 has not been fully elucidated in breast cancer cells. Here, we investigated whether STC‑1 acts as a prognostic factor in triple‑negative breast cancer (TNBC) patients, and we explored the cellular mechanism in breast cancer cells. The level of STC‑1 expression was directly associated with the relapse‑free and overall survival of basal‑type breast cancer patients...
September 2016: Oncology Reports
https://www.readbyqxmd.com/read/27437760/effect-of-vitamin-k-in-bone-metabolism-and-vascular-calcification-a-review-of-mechanisms-of-action-and-evidences
#10
Julia Khéde Dourado Villa, Marisa Alves Nogueira Diaz, Virgínia Ramos Pizziolo, Hércia Stampini Duarte Martino
Osteoporosis is a public health concern associated with an increased risk of bone fractures and vascular calcification. Vitamin K presents unique benefits on these issues, although understudied. The two main forms of vitamin K are phylloquinone (vitamin K1) and menaquinone (vitamin K2). In this study, it was especially investigated the action of vitamin K2 in bones and vessels. Vitamin K2 has shown to stimulate bone formation by promoting osteoblast differentiation and carboxylation of osteocalcin, and increasing alkaline phosphatase, insulin-like growth factor-1, growth differentiation factor-15, and stanniocalcin 2 levels...
July 20, 2016: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/27420048/stanniocalcin-1-protects-a-mouse-model-from-renal-ischemia-reperfusion-injury-by-affecting-ros-mediated-multiple-signaling-pathways
#11
Dajun Liu, Huiping Shang, Ying Liu
Stanniocalcin-1 (STC-1) protects against renal ischemia-reperfusion injury (RIRI). However, the molecular mechanisms remain widely unknown. STC-1 inhibits reactive oxygen species (ROS), whereas most ROS-mediated pathways are associated with ischemic injury. Therefore, to explore the mechanism, the effects of STC-1 on ROS-medicated pathways were studied. Non-traumatic vascular clamps were used to establish RIRI mouse models. The serum levels of STC-1, interleukin-6 (IL-6), interferon (IFN) γ, P53, and capase-3 were measured by ELISA kits...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27409607/regulation-of-intestinal-epithelial-calcium-transport-proteins-by-stanniocalcin-1-in-caco2-cells
#12
Jinmei Xiang, Rui Guo, Chunyun Wan, Liming Wu, Shijin Yang, Dingzong Guo
Stanniocalcin-1 (STC1) is a calcium and phosphate regulatory hormone. However, the exact molecular mechanisms underlying how STC1 affects Ca(2+) uptake remain unclear. Here, the expression levels of the calcium transport proteins involved in transcellular transport in Caco2 cells were examined following over-expression or inhibition of STC1. These proteins include the transient receptor potential vanilloid members (TRPV) 5 and 6, the plasma membrane calcium ATPase 1b (PMCA1b), the sodium/calcium exchanger (NCX1), and the vitamin D receptor (VDR)...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27346255/contrasting-effects-of-stanniocalcin-related-polypeptides-on-macrophage-foam-cell-formation-and-vascular-smooth-muscle-cell-migration
#13
Keigo Yamamoto, Yukie Tajima, Akinori Hasegawa, Yui Takahashi, Miho Kojima, Rena Watanabe, Kengo Sato, Masayoshi Shichiri, Takuya Watanabe
Stanniocalcin (STC) is a calcium- and phosphate-regulating hormone secreted by the corpuscles of Stannius, an endocrine gland of bony fish. Its human homologues, STC1 and STC2 showing 34% amino acid identity each other, are expressed in a variety of human tissues. To clarify their roles in atherosclerosis, we investigated the effects of their full-length proteins, STC1(18-247) and STC2(25-302), and STC2-derived fragment peptides, STC2(80-100) and STC2(85-99), on inflammatory responses in human umbilical vein endothelial cells (HUVECs), human macrophage foam cell formation, the migration and proliferation of human aortic smooth muscle cells (HASMCs) and the extracellular matrix expression...
August 2016: Peptides
https://www.readbyqxmd.com/read/27322879/stanniocalcin-1-expression-in-normal-human-endometrium-and-dysregulation-in-endometriosis
#14
Lusine Aghajanova, Signe Altmäe, Sergo Kasvandik, Andres Salumets, Anneli Stavreus-Evers, Linda C Giudice
OBJECTIVE: To determine expression of stanniocalcin-1 (STC1) in human endometrium with and without endometriosis and its regulation by steroid hormones. DESIGN: Laboratory study. SETTING: University. PATIENT(S): Nineteen women with endometriosis and 33 control women. INTERVENTION(S): Endometrial biopsy and fluid sampling. MAIN OUTCOME MEASURE(S): Analysis of early secretory (ESE) and midsecretory (MSE) endometrial secretomes from fertile women with the use of nano-liquid chromatography-dual mass spectrometry; real-time quantitative polymerase chain reaction, and immunohistochemistry for STC1 and its receptor calcium-sensing receptor (CASR) mRNA and proteins in endometrium with and without endometriosis; evaluation of STC1 and CASR mRNA expression in endometrial stromal fibroblasts (eSF) from women with and without endometriosis decidualized with the use of E2P or 8-bromo-cyclic adenosine monophosphate (cAMP)...
September 1, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27156337/stc1-and-nf-%C3%AE%C2%BAb-p65-rel-a-is-constitutively-activated-in-colorectal-cancer
#15
Saleheh Rezapour, Tayyeb Bahrami, Shahryar Hashemzadeh, Mehrdad Asghari Estiar, Masoumeh Nemati, Reyhaneh Ravanbakhsh, Mohammad Ali Hosseinpour Feizi, Hossein Samadi Kafil, Nasser Pouladi, Morteza Ghojazadeh, Ebrahim Sakhinia
BACKGROUND: Stanniocalcin-1 (STC1) and nuclear factor (NF)-κB subunit p65 transcription factor are involved in various types of human malignancies. The roles of STC1 and NFκB-p65 in colorectal cancer (CRC) are still not fully understood. We investigated expression levels of NF-κB p65 and STC1 and also correlations between STC1 and NF-κB p65 expression and clinicopathological features in CRC. METHODS: Tumor tissue samples were collected from 48 patients with CRC...
2016: Clinical Laboratory
https://www.readbyqxmd.com/read/27136000/crossbred-steer-temperament-as-yearlings-and-whole-genome-association-of-steer-temperament-as-yearlings-and-calf-temperament-post-weaning
#16
D G Riley, C A Gill, C R Boldt, R R Funkhouser, A D Herring, P K Riggs, J E Sawyer, D K Lunt, J O Sanders
cattle often have the reputation for a poor or dangerous temperament. Identification of genomic regions that associate with temperament of such cattle may be useful for genetic improvement strategies. The objectives of this study were to evaluate subjective temperament scores (1 to 9; higher scores indicated more unfavorable temperament) for aggressiveness, nervousness, flightiness, gregariousness, and overall temperament of one-half steers in feedlot conditions at 1 yr of age and compare those scores of those steers when evaluated approximately 1 mo postweaning, and conduct whole genome association analyses using SNP markers and the temperament traits of those steers at 1 yr of age and for temperament traits of all calves at weaning...
April 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/26874357/the-proteolytic-activity-of-pregnancy-associated-plasma-protein-a-is-potentially-regulated-by-stanniocalcin-1-and-2-during-human-ovarian-follicle-development
#17
Malene R Jepsen, Søren Kløverpris, Jane A Bøtkjær, Marie L Wissing, Claus Y Andersen, Claus Oxvig
STUDY QUESTION: Is the proteolytic activity of pregnancy-associated plasma protein-A (PAPP-A) regulated by the stanniocalcins (STC1 and STC2) during human follicle maturation? SUMMARY ANSWER: The STCs and PAPP-A show similar expression by immunohistochemistry in developing follicles, and regulation of PAPP-A proteolytic activity is suggested by the identification of inhibited protein complexes between PAPP-A and STC1 or STC2 in human follicular fluid (FF). WHAT IS KNOWN ALREADY: The insulin-like growth factor (IGF)-regulating proteinase PAPP-A is secreted by the granulosa cells of estrogen-dominant follicles and is involved in follicle growth...
April 2016: Human Reproduction
https://www.readbyqxmd.com/read/26762409/secretome-profiling-of-oral-squamous-cell-carcinoma-associated-fibroblasts-reveals-organization-and-disassembly-of-extracellular-matrix-and-collagen-metabolic-process-signatures
#18
Elizabete Bagordakis, Iris Sawazaki-Calone, Carolina Carneiro Soares Macedo, Carolina M Carnielli, Carine Ervolino de Oliveira, Priscila Campioni Rodrigues, Ana Lucia C A Rangel, Jean Nunes Dos Santos, Juha Risteli, Edgard Graner, Tuula Salo, Adriana Franco Paes Leme, Ricardo D Coletta
An important role has been attributed to cancer-associated fibroblasts (CAFs) in the tumorigenesis of oral squamous cell carcinoma (OSCC), the most common tumor of the oral cavity. Previous studies demonstrated that CAF-secreted molecules promote the proliferation and invasion of OSCC cells, inducing a more aggressive phenotype. In this study, we searched for differences in the secretome of CAFs and normal oral fibroblasts (NOF) using mass spectrometry-based proteomics and biological network analysis. Comparison of the secretome profiles revealed that upregulated proteins involved mainly in extracellular matrix organization and disassembly and collagen metabolism...
July 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/26640170/stanniocalcin-1-inhibits-thrombin-induced-signaling-and-protects-from-bleomycin-induced-lung-injury
#19
Luping Huang, Lin Zhang, Huiming Ju, Qingtian Li, Jenny Szu-Chin Pan, Zahraa Al-Lawati, David Sheikh-Hamad
Thrombin-induced and proteinase-activated receptor 1 (PAR1)-mediated signaling increases ROS production, activates ERK, and promotes inflammation and fibroblast proliferation in bleomycin-induced lung injury. Stanniocalcin-1 (STC1) activates anti-oxidant pathways, inhibits inflammation and provides cytoprotection; hence, we hypothesized that STC1 will inhibit thrombin/PAR1 signaling and protect from bleomycin-induced pneumonitis. We determined thrombin level and activity, thrombin-induced PAR-1-mediated signaling, superoxide generation and lung pathology after intra-tracheal administration of bleomycin to WT and STC1 Tg mice...
December 7, 2015: Scientific Reports
https://www.readbyqxmd.com/read/26600749/osmoregulation-in-zebrafish-ion-transport-mechanisms-and-functional-regulation
#20
REVIEW
Ying-Jey Guh, Chia-Hao Lin, Pung-Pung Hwang
Fish, like mammals, have to maintain their body fluid ionic and osmotic homeostasis through sophisticated iono-/osmoregulation mechanisms, which are conducted mainly by ionocytes of the gill (the skin in embryonic stages), instead of the renal tubular cells in mammals. Given the advantages in terms of genetic database availability and manipulation, zebrafish is an emerging model for research into regulatory and integrative physiology. At least five types of ionocytes, HR, NaR, NCC, SLC26, and KS cells, have been identified to carry out Na(+) uptake/H(+) secretion/NH4 (+) excretion, Ca(2+) uptake, Na(+)/Cl(-) uptake, K(+) secretion, and Cl(-) uptake/HCO3 (-) secretion, respectively, through distinct sets of transporters...
2015: EXCLI journal
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