Ramya Ramaswami, Takanobu Tagawa, Guruswamy Mahesh, Anna Serquina, Vishal Koparde, Kathryn Lurain, Sarah Dremel, Xiaofan Li, Ameera Mungale, Alex Beran, Zoe Weaver Ohler, Laura Bassel, Andrew Warner, Ralph Mangusan, Anaida Widell, Irene Ekwede, Laurie T Krug, Thomas S Uldrick, Robert Yarchoan, Joseph M Ziegelbauer
BACKGROUND: Kaposi sarcoma (KS) is a multicentric tumor caused by Kaposi sarcoma herpesvirus (KSHV) that leads to morbidity and mortality among people with HIV worldwide. KS commonly involves the skin but can occur in the gastrointestinal tract (GI) in severe cases. METHODS: RNA sequencing was used to compare the cellular and KSHV gene expression signatures of skin and GI KS lesions in 44 paired samples from 19 participants with KS alone or with concurrent KSHV-associated diseases...
September 22, 2023: Journal of Translational Medicine