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Stanniocalcin 1

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https://www.readbyqxmd.com/read/29748538/stanniocalcin-2-contributes-to-mesenchymal-stromal-cells-attenuating-murine-contact-hypersensitivity-mainly-via-reducing-cd8-tc1-cells
#1
Xiaoyong Chen, Qiuli Liu, Weijun Huang, Chuang Cai, Wenjie Xia, Yanwen Peng, Shuwei Zheng, Gang Li, Yan Xu, Jiancheng Wang, Chang Liu, Xiaoran Zhang, Li Huang, Andy Peng Xiang, Qi Zhang
Mesenchymal stromal cells (MSCs) have been demonstrated to ameliorate allergic contact dermatitis (ACD), a typical T-cell-mediated disorder. However, the underlying mechanisms behind the MSC-based treatment for ACD have not yet been fully elucidated. The stanniocalcins (STCs) comprise a family of secreted glycoprotein hormones that act as important anti-inflammatory proteins. Here, we investigated the roles of STCs in MSC-mediated T-cell suppression and their potential role in the MSC-based treatment for ACD...
May 10, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29721098/capg-enhances-breast-cancer-metastasis-by-competing-with-prmt5-to-modulate-stc-1-transcription
#2
Sheng Huang, Yayun Chi, Yi Qin, Ziliang Wang, Bingqiu Xiu, Yonghui Su, Rong Guo, Liang Guo, Hefen Sun, Chujia Zeng, Shuling Zhou, Xin Hu, Sheng Liu, Zhimin Shao, Zhaohui Wu, Wei Jin, Jiong Wu
Macrophage-capping protein (CAPG) has been shown to promote cancer cell metastasis, although the mechanism remains poorly understood. Methods: Breast cancer (BC) tissue microarray was used to test the role of CAPG in the prognosis of BC patients. Xenograft mice model was used to validate the metastasis promotion role of CAPG in vivo. Gene expression array, chromatin immunoprecipitation and luciferase report assay were performed to search for the target genes of CAPG. Protein immunoprecipitation, MS/MS analysis, tissue microarray and histone methyltransferase assay were used to explore the mechanism of CAPG regulating stanniocalcin 1 (STC-1) transcription...
2018: Theranostics
https://www.readbyqxmd.com/read/29712555/prognostic-value-of-the-stanniocalcin-2-papp-a-igfbp-4-axis-in-st-segment-elevation-myocardial-infarction
#3
Germán Cediel, Ferran Rueda, Claus Oxvig, Teresa Oliveras, Carlos Labata, Oriol de Diego, Marc Ferrer, M Cruz Aranda-Nevado, Judith Serra-Gregori, Julio Núñez, Cosme García, Antoni Bayes-Genis
OBJECTIVE: The aim of the present study was to evaluate the prognostic value of the Stanniocalcin-2/PAPP-A/IGFBP-4 axis in patients with ST-segment elevation myocardial infarction (STEMI). METHODS: Observational cohort study performed in 1085 consecutive STEMI patients treated with early reperfusion between February 2011 and August 2014. Stanniocalcin-2, PAPP-A, and IGFBP-4 were measured using state-of-the art immunoassays. The primary outcome was the composite endpoint of all-cause mortality and readmission due to heart failure (HF)...
April 30, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29593009/stanniocalcin-expression-as-a-predictor-of-late-breast-cancer-recurrence
#4
Kristen D Brantley, Anders Kjærsgaard, Deirdre Cronin-Fenton, Rami Yacoub, Anja S Nielsen, Kristina L Lauridsen, Stephen Hamilton-Dutoit, Timothy L Lash
BACKGROUND: Expression of human paracrine hormones stanniocalcin 1 (STC1) and stanniocalcin 2 (STC2) may potentiate late breast cancer recurrence. We tested the hypothesis that expression of STC1 and STC2 in primary breast tumors is more strongly associated with late versus early recurrences. METHODS: 541 estrogen receptor positive, tamoxifen treated (ER+/TAM+) and 300 estrogen receptor negative, tamoxifen untreated (ER-/TAM-) breast cancer patients who experienced recurrence within ten years of primary diagnosis and matched recurrence-free controls were selected from a cohort of 11,251 Danish breast cancer patients diagnosed with stage I, II, or III breast cancer during 1985-2001...
March 28, 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29490350/intravitreal-stanniocalcin-1-enhances-new-blood-vessel-growth-in-a-rat-model-of-laser-induced-choroidal-neovascularization
#5
Min Zhao, Wankun Xie, Shu-Huai Tsai, Travis W Hein, Brent A Rocke, Lih Kuo, Robert H Rosa
Purpose: The purpose of this study was to investigate the impact of stanniocalcin-1 (STC-1), a photoreceptor-protective glycoprotein, on the development of choroidal neovascularization (CNV) in relation to VEGF and its main receptor (VEGFR2) expression after laser injury. Methods: In rats, CNV was induced by laser photocoagulation in both eyes, followed by intravitreal injection of STC-1 in the right eye and vehicle or denatured STC-1 injection in the left eye as control...
February 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29467934/effects-of-stc1-overexpression-on-tumorigenicity-and-metabolism-of-hepatocellular-carcinoma
#6
Cherry Ct Leung, Chris Kc Wong
Stanniocalcin-1 (STC1) is a paracrine factor associated with inflammation and carcinogenesis. Using clinicopathological data, we previously reported that a greater expression of STC1 in hepatocellular carcinoma (HCC) was significantly correlated with smaller tumor size. The underlying mechanism on the correlation is not known. In this study, using a metastatic HCC cell-line (MHCC-97L, P) and lentiviral vector mediated-STC1 overexpression, the inoculation of STC1-overexpressing MHCC-97L (S1) cells in a nude mice xenograft model demonstrated reductions in tumor mass and volume...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29434214/mesenchymal-stromal-cells-inhibit-nlrp3-inflammasome-activation-in-a-model-of-coxsackievirus-b3-induced-inflammatory-cardiomyopathy
#7
Kapka Miteva, Kathleen Pappritz, Marzena Sosnowski, Muhammad El-Shafeey, Irene Müller, Fengquan Dong, Konstantinos Savvatis, Jochen Ringe, Carsten Tschöpe, Sophie Van Linthout
Inflammation in myocarditis induces cardiac injury and triggers disease progression to heart failure. NLRP3 inflammasome activation is a newly identified amplifying step in the pathogenesis of myocarditis. We previously have demonstrated that mesenchymal stromal cells (MSC) are cardioprotective in Coxsackievirus B3 (CVB3)-induced myocarditis. In this study, MSC markedly inhibited left ventricular (LV) NOD2, NLRP3, ASC, caspase-1, IL-1β, and IL-18 mRNA expression in CVB3-infected mice. ASC protein expression, essential for NLRP3 inflammasome assembly, increased upon CVB3 infection and was abrogated in MSC-treated mice...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29280739/novel-modulators-of-the-growth-hormone-insulin-like-growth-factor-axis-pregnancy-associated-plasma-protein-a2-and-stanniocalcin-2
#8
Masanobu Fujimoto, Vivian Hwa, Andrew Dauber
Growth hormone (GH) and its mediator, insulin-like growth factor-1 (IGF-1), play a critical role in human growth. In circulation, IGF-1 is found in a ternary complex with IGF binding proteins (IGFBPs) and acid labile subunit (ALS) but little attention has been paid to the regulation of IGF-1 bioavailability. Recently, pregnancy-associated plasma protein-A2 (PAPP-A2) and stanniocalcin-2 (STC2) were identified as novel modulators of IGF-I bioavailability. PAPP-A2 is a protease which cleaves IGFBP-3 and -5, while STC2 inhibits PAPP-A and PAPP-A2 activity...
December 30, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29196129/stanniocalcin-1-augments-stem-like-traits-of-glioblastoma-cells-through-binding-and-activating-notch1
#9
Yong Li, Zhi-Cheng He, Xiao-Ning Zhang, Qing Liu, Cong Chen, Zheng Zhu, Qian Chen, Yu Shi, Xiao-Hong Yao, You-Hong Cui, Xia Zhang, Yan Wang, Hsiang-Fu Kung, Yi-Fang Ping, Xiu-Wu Bian
Glioblastoma (GBM) is a fatal tumor and comprises heterogeneous cells in which a subpopulation with stem cell-like properties is included. Cancer cells with stem cell-like properties account for tumor initiation, drug resistance and recurrence. To identify and characterize specific factors in regulating stem-like traits is critical for GBM therapeutic. Here, we showed that Stanniocalcin-1 (STC1), a secretory glycoprotein, functions as a novel stimulator for stem-like traits of GBM cells. We found STC1 was prominently expressed in glioma spheres which are mainly comprised of glioma stem-like cells...
March 1, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29065179/comparative-proteome-and-peptidome-analysis-of-the-cephalic-fluid-secreted-by-arapaima-gigas-teleostei-osteoglossidae-during-and-outside-parental-care
#10
COMPARATIVE STUDY
Lucas S Torati, Hervé Migaud, Mary K Doherty, Justyna Siwy, Willian Mullen, Pedro E C Mesquita, Amaya Albalat
Parental investment in Arapaima gigas includes nest building and guarding, followed by a care provision when a cephalic fluid is released from the parents' head to the offspring. This fluid has presumably important functions for the offspring but so far its composition has not been characterised. In this study the proteome and peptidome of the cephalic secretion was studied in parental and non-parental fish using capillary electrophoresis coupled to mass spectrometry (CE-MS) and GeLC-MS/MS analyses. Multiple comparisons revealed 28 peptides were significantly different between males and parental males (PC-males), 126 between females and parental females (PC-females), 51 between males and females and 9 between PC-males and PC-females...
2017: PloS One
https://www.readbyqxmd.com/read/28974356/long-term-photoreceptor-rescue-in-two-rodent-models-of-retinitis-pigmentosa-by-adeno-associated-virus-delivery-of-stanniocalcin-1
#11
Gavin W Roddy, Douglas Yasumura, Michael T Matthes, Marcel V Alavi, Sanford L Boye, Robert H Rosa, Michael P Fautsch, William W Hauswirth, Matthew M LaVail
Retinal degenerations, including age-related macular degeneration and the retinitis pigmentosa family of diseases, are among the leading causes of legal blindness in the United States. We previously found that Stanniocalcin-1 (STC-1) reduced photoreceptor loss in the S334ter-3 and Royal College of Surgeons rat models of retinal degeneration. The results were attributed in part to a reduction in oxidative stress. Herein, we tested the hypothesis that long-term delivery of STC-1 would provide therapeutic rescue in more chronic models of retinal degeneration...
December 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28945869/effects-of-prednisolone-on-serum-and-tissue-fluid-igf-i-receptor-activation-and-post-receptor-signaling-in-humans
#12
RANDOMIZED CONTROLLED TRIAL
Nilani Ramshanker, Maiken Aagaard, Rikke Hjortebjerg, Thomas Schmidt Voss, Niels Møller, Jens Otto Lunde Jørgensen, Niels Jessen, Peter Bjerring, Nils Erik Magnusson, Mette Bjerre, Claus Oxvig, Jan Frystyk
Context: Short-term glucocorticoid exposure increases serum insulinlike growth factor I (IGF-I) concentrations but antagonizes IGF-I tissue signaling. The underlying mechanisms remain unknown. Objective: To identify at which levels glucocorticoid inhibits IGF-I signaling. Design and Methods: Nineteen healthy males received prednisolone (37.5 mg/d) and placebo for 5 days in a randomized, double-blinded, placebo-controlled crossover study. Serum was collected on days 1, 3, and 5, and abdominal skin suction blister fluid (SBF; ~interstitial fluid) was taken on day 5 (n = 9) together with muscle biopsy specimens (n = 19)...
November 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28911149/insulin-like-growth-factor-bioactivity-stanniocalcin-2-pregnancy-associated-plasma-protein-a-and-igf-binding-protein-4-in-pleural-fluid-and-serum-from-patients-with-pulmonary-disease
#13
COMPARATIVE STUDY
Ulrick Skipper Espelund, Mette Bjerre, Rikke Hjortebjerg, Torben Riis Rasmussen, Anders Lundby, Andreas Hoeflich, Birgitte Holst Folkersen, Claus Oxvig, Jan Frystyk
Context: Members of the insulin-like growth factor (IGF) system are primarily produced in the liver and secreted into the circulation, but they are also produced, recruited, and activated locally in tissues. Objective: To compare activity and concentrations of IGF system components in pleural fluid and blood. Design: Pathological pleural fluid, secondary to lung cancer or nonmalignant disease, and matching blood samples were collected from 24 patients ages 66...
September 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28801361/one-level-up-abnormal-proteolytic-regulation-of-igf-activity-plays-a-role-in-human-pathophysiology
#14
REVIEW
Jesús Argente, Julie A Chowen, Luis A Pérez-Jurado, Jan Frystyk, Claus Oxvig
The discovery of a mutation in a specific gene can be very important for determining the pathophysiology underlying the disease of a patient and may also help to decide the best treatment protocol on an individual basis. However, sometimes the discovery of mutations in new proteins advances our comprehension in a more widespread manner. The growth hormone (GH)/insulin-like growth factor (IGF)-1 axis is fundamental for systemic growth, but is also involved in many other important processes. Our understanding of this system in physiology and pathophysiology has advanced throughout the years with each discovery of mutations in members of this axis...
October 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28688970/secretory-stanniocalcin-1-promotes-metastasis-of-hepatocellular-carcinoma-through-activation-of-jnk-signaling-pathway
#15
Kristy Kwan-Shuen Chan, Carmen Oi-Ning Leung, Carmen Chak-Lui Wong, Daniel Wai-Hung Ho, Kenneth Siu-Ho Chok, Ching-Lung Lai, Irene Oi-Lin Ng, Regina Cheuk-Lam Lo
The hypoxic microenvironment is well-characterized in hepatocellular carcinoma (HCC). Delineation of hypoxia-responsive events is an integral part to understand the pathogenesis of HCC. We studied the functional role and clinical relevance of Stanniocalcin 1 (STC1), a hypoxia-induced molecular target, in HCC. In our clinical cohort, STC1 transcript was up-regulated in HCC tumor tissues. Moreover, STC1 protein was detected in the sera of HCC patients. A higher serum STC1 level was correlated with larger tumor size and poorer 5-year disease-free survival...
September 10, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28665755/depletion-of-carbonic-anhydrase-ix-abrogates-hypoxia-induced-overexpression-of-stanniocalcin-1-in-triple-negative-breast-cancer-cells
#16
Elīna Zandberga, Pawel Zayakin, Artūrs Ābols, Dārta Pūpola, Pēteris Trapencieris, Aija Linē
Carbonic anhydrase IX (CAIX) is a pH-regulating enzyme that plays a key role in maintaining an alkaline intracellular pH under hypoxic conditions. It is overexpressed in a variety of solid cancers, including breast cancer (BC), and has been implicated in the migration, invasion and stemness of breast cancer cells. Therefore, CAIX recently emerged as a novel therapeutic target for the treatment of BC. To gain an insight into the mechanism of action of CAIX inhibitors, we investigated the impact of CAIX knock-down on the transcriptional response to hypoxia in 2 BC cell lines - MCF7 and MDA-MB-231, by performing a global gene expression analysis...
August 3, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28655163/microrna-21a-5p-pdcd4-axis-regulates-mesenchymal-stem-cell-induced-neuroprotection-in-acute-glaucoma
#17
Wenru Su, Zuohong Li, Y Jia, Yingting Zhu, Wenjia Cai, Peixing Wan, Yingying Zhang, Song Guo Zheng, Yehong Zhuo
Mesenchymal stem cells (MSCs) have been demonstrated to have promising therapeutic benefits for a variety of neurological diseases; however, the underlying mechanisms are poorly understood. Here, we showed that intravitreal infusion of MSCs promoted retinal ganglion cell (RGC) survival in a mouse model of acute glaucoma, with significant inhibition of microglial activation, production of TNF-α, IL-1β, and reactive oxygen species, as well as caspase-8 and caspase-3 activation. In vitro, MSCs inhibited both caspase-8-mediated RGC apoptosis and microglial activation, partly via the action of stanniocalcin 1 (STC1)...
August 1, 2017: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/28538979/stanniocalcin-1-is-an-ocular-hypotensive-agent-and-a-downstream-effector-molecule-that-is-necessary-for-the-intraocular-pressure-lowering-effects-of-latanoprost
#18
Gavin W Roddy, Kimberly B Viker, Nelson S Winkler, Cindy K Bahler, Bradley H Holman, David Sheikh-Hamad, Uttio Roy Chowdhury, W Daniel Stamer, Michael P Fautsch
Purpose: To identify downstream signaling molecules through which intraocular pressure (IOP) is lowered following treatment with the prostaglandin analog latanoprost. Methods: Total RNA and protein isolated from primary human Schlemm's canal cells (n = 3) treated with latanoprost (free acid; 100 nM) were processed for quantitative PCR and Western blot analysis. IOP was evaluated in stanniocalcin-1 (STC-1-/-) and wild-type mice following treatment with latanoprost or Rho kinase inhibitor Y27632...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28435144/effects-of-stanniocalcin-1-on-glucose-flux-in-rat-brown-adipose-tissue
#19
Aline G Cozer, Márcia Trapp, Tiago L Martins, Luciano Stürmer De Fraga, Claudia Vieira Marques, Jorge Felipe A Model, Vanessa Schein, Luiz Carlos Kucharski, Roselis S M Da Silva
The present work assesses in vitro the role of human Stanniocalcin 1 (hSTC-1) in (14)C-glucose metabolism in brown adipose tissue (BAT) from fed rat. In the fed state, hSTC-1 decreases the incorporation of (14)C from glucose into lipids in the rat BAT. The data support the hypothesis that the capacity of the glycerol-3-phosphate (G3P)-generating pathway (glycolysis) from glucose is regulated by hSTC-1, decreasing the adequate supply of G3P needed for fatty acid esterification and triacylglycerol (TG) storage in BAT...
July 2017: Biochimie
https://www.readbyqxmd.com/read/28350121/stanniocalcin-1-promotes-cell-proliferation-via-cyclin%C3%A2-e1-cyclin%C3%A2-dependent-kinase-2-in-human-prostate-carcinoma
#20
Yao Bai, Yichen Xiao, Yuanqing Dai, Xiong Chen, Dongjie Li, Xinji Tan, Xiaobo Zhang
Stanniocalcin 1 (STC1) is a glycoprotein hormone that is involved in calcium/phosphate homeostasis. Increasing evidence suggests that STC1 is involved in carcinogenesis; however, few studies have defined the mechanisms and functional roles of STC1 activity in prostate carcinogenesis. In the present study, MTT, flow cytometry and colony formation assays, and small interfering RNA (siRNA) and overexpression in multiple cell lines were used to investigate the function of STC1 in prostate carcinoma in vivo and in vivo...
April 2017: Oncology Reports
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