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https://www.readbyqxmd.com/read/28721605/how-to-provide-gadolinium-free-pet-mr-cancer-staging-of-children-and-young-adults-in-less-than-1%C3%A2-h-the-stanford-approach
#1
Anne M Muehe, Ashok J Theruvath, Lillian Lai, Maryam Aghighi, Andrew Quon, Samantha J Holdsworth, Jia Wang, Sandra Luna-Fineman, Neyssa Marina, Ranjana Advani, Jarrett Rosenberg, Heike E Daldrup-Link
PURPOSE: To provide clinically useful gadolinium-free whole-body cancer staging of children and young adults with integrated positron emission tomography/magnetic resonance (PET/MR) imaging in less than 1 h. PROCEDURES: In this prospective clinical trial, 20 children and young adults (11-30 years old, 6 male, 14 female) with solid tumors underwent 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) PET/MR on a 3T PET/MR scanner after intravenous injection of ferumoxytol (5 mg Fe/kg) and [(18)F]FDG (2-3 MBq/kg)...
July 18, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28719629/multiparametric-11c-acetate-positron-emission-tomography-magnetic-resonance-imaging-in-the-assessment-and-staging-of-prostate-cancer
#2
Stephan H Polanec, Piotr Andrzejewski, Pascal A T Baltzer, Thomas H Helbich, Alexander Stiglbauer, Dietmar Georg, Georgios Karanikas, Martin Susani, Wolfgang Wadsak, Markus Margreiter, Markus Mitterhauser, Peter Brader, Katja Pinker
BACKGROUND: The aim of this study was to evaluate whether MP [11C]Acetate PET-MRI enables an accurate differentiation of benign and malignant prostate tumors as well as local and distant staging. MATERIALS AND METHODS: Fifty-six consecutive patients fulfilling the following criteria were included in this IRB-approved prospective study: elevated PSA levels or suspicious findings at digital rectal examination or TRUS; and histopathological verification. All patients underwent MP [11C]Acetate PET-MRI of the prostate performed on separate scanners with PET/CT using [11C]Acetate and 3T MP MR imaging...
2017: PloS One
https://www.readbyqxmd.com/read/28716214/early-68-ga-psma-pet-mri-acquisition-assessment-of-lesion-detectability-and-pet-metrics-in-patients-with-prostate-cancer-undergoing-same-day-late-pet-ct
#3
L Domachevsky, H Bernstine, N Goldberg, M Nidam, D Stern, J Sosna, D Groshar
AIM: To compare lesion detectability and positron-emission tomography (PET) metric measurements between early-PET/magnetic resonance imaging (MRI) acquisition and same-day PET/computed tomography (CT). MATERIALS AND METHODS: The study was approved by the institutional review board and written informed consent was obtained from all patients. Twenty-one patients underwent non-time-of-flight (TOF) PET/MRI immediately following (68)GA-prostate-specific membrane antigen (PSMA) tracer injection in two steps: firstly, early prostate PET/MRI (pPET/MRI) and early whole-body (WB) PET/MRI (wbPET/MR) followed by WB TOF PET/CT (wbPET/CT)...
July 14, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28707963/in-vivo-assessment-of-ovarian-tumor-response-to-tyrosine-kinase-inhibitor-pazopanib-by-using-hyperpolarized-13-c-pyruvate-mr-spectroscopy-and-18-f-fdg-pet-ct-imaging-in-a-mouse-model
#4
Murali K Ravoori, Sheela P Singh, Jaehyuk Lee, James A Bankson, Vikas Kundra
Purpose To assess in a mouse model whether early or late components of glucose metabolism, exemplified by fluorine 18 ((18)F) fluorodeoxyglucose (FDG) positron emission tomography (PET) and hyperpolarized carbon 13 ((13)C)-pyruvate magnetic resonance (MR) spectroscopy, can serve as indicators of response in ovarian cancer to multityrosine kinase inhibitor pazopanib. Materials and Methods In this Animal Care and Use Committee approved study, 17 days after the injection of 2 × 10(6) human ovarian SKOV3 tumors cells into 14 female nude mice, treatment with vehicle or pazopanib (2...
July 13, 2017: Radiology
https://www.readbyqxmd.com/read/28703340/core-satellite-polydopamine-gadolinium-metallofullerene-nanotheranostics-for-multimodal-imaging-guided-combination-cancer-therapy
#5
Sheng Wang, Jing Lin, Zhantong Wang, Zijian Zhou, Ruiliang Bai, Nan Lu, Yijing Liu, Xiao Fu, Orit Jacobson, Wenpei Fan, Junle Qu, Siping Chen, Tianfu Wang, Peng Huang, Xiaoyuan Chen
Integration of magnetic resonance imaging (MRI) and other imaging modalities is promising to furnish complementary information for accurate cancer diagnosis and imaging-guided therapy. However, most gadolinium (Gd)-chelator MR contrast agents are limited by their relatively low relaxivity and high risk of released-Gd-ions-associated toxicity. Herein, a radionuclide-(64) Cu-labeled doxorubicin-loaded polydopamine (PDA)-gadolinium-metallofullerene core-satellite nanotheranostic agent (denoted as CDPGM) is developed for MR/photoacoustic (PA)/positron emission tomography (PET) multimodal imaging-guided combination cancer therapy...
July 13, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28695407/nuclear-cardiology-in-china-2017
#6
Gongshun Tang
This paper provides the current state of nuclear cardiology in China and contrasts it with the state of nuclear cardiology in the United States (US). The West China Hospital and New York-Presbyterian Hospital (NYPH) were used as representative hospitals to contrast nuclear cardiology in China and the US, respectively. In 2015, there were 101 medical cyclotrons, 774 SPECT or SPECT/CT, 240 PET/CT, and 6 PET/MR cameras in China. Most (~90%) of the nuclear cardiology studies are gated SPECT myocardial perfusion imaging (MPI), and ~10% are other types of studies including MUGA, PET/CT MPI, and viability studies...
July 10, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28695243/cns-metabolism-in-high-risk-drug-abuse-insights-gained-from-1-h-31-p-mrs-and-pet
#7
REVIEW
S Bodea
BACKGROUND: High-risk drug consumption is a matter of great concern for public health actors in industrialised countries. The latest trends show a market tendency towards diversification and increasing demand for high-purity synthetic drugs. While most consumers seek medical help after cannabis use, it is high-risk drugs like cocaine, heroin and amphetamines that account for most of the 1000 drug-related deaths that occur in Germany every year. PURPOSE: This article presents the most prominent in vivo cerebral metabolic information in cocaine, heroin and methamphetamine users provided by MRI spectroscopy and PET imaging...
July 10, 2017: Der Radiologe
https://www.readbyqxmd.com/read/28687866/quantification-improvement-and-harmonization-of-small-lesion-detection-with-state-of-the-art-pet
#8
REVIEW
Charlotte S van der Vos, Daniëlle Koopman, Sjoerd Rijnsdorp, Albert J Arends, Ronald Boellaard, Jorn A van Dalen, Mark Lubberink, Antoon T M Willemsen, Eric P Visser
In recent years, there have been multiple advances in positron emission tomography/computed tomography (PET/CT) that improve cancer imaging. The present generation of PET/CT scanners introduces new hardware, software, and acquisition methods. This review describes these new developments, which include time-of-flight (TOF), point-spread-function (PSF), maximum-a-posteriori (MAP) based reconstruction, smaller voxels, respiratory gating, metal artefact reduction, and administration of quadratic weight-dependent (18)F-fluorodeoxyglucose (FDG) activity...
July 8, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28684867/combined-magnetomotive-ultrasound-pet-ct-and-mr-imaging-of-68-ga-labelled-superparamagnetic-iron-oxide-nanoparticles-in-rat-sentinel-lymph-nodes-in-vivo
#9
Maria Evertsson, Pontus Kjellman, Magnus Cinthio, Roger Andersson, Thuy A Tran, Rene In't Zandt, Gustav Grafström, Hanna Toftevall, Sarah Fredriksson, Christian Ingvar, Sven-Erik Strand, Tomas Jansson
Current methods for intra-surgical guidance to localize metastases at cancer surgery are based on radioactive tracers that cause logistical challenges. We propose the use of a novel ultrasound-based method, magnetomotive ultrasound (MMUS) imaging that employ a nanoparticle-based contrast agent that also may be used for pre-operative PET/MRI imaging. Since MMUS is radiation free, this eliminates the dependence between pre- and intra-operative imaging and the radiation exposure for the surgical staff. This study investigates a hypothetical clinical scenario of pre-operative PET imaging, combined with intra-operative MMUS imaging, implemented in a sentinel lymph node (SLN) rat model...
July 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28683109/18-f-fdg-pet-mr-imaging-in-patients-with-suspected-liver-lesions-value-of-liver-specific-contrast-agent-gadobenate-dimeglumine
#10
Julian Kirchner, Lino M Sawicki, Cornelius Deuschl, Johannes Grüneisen, Karsten Beiderwellen, Thomas C Lauenstein, Ken Herrmann, Michael Forsting, Philipp Heusch, Lale Umutlu
OBJECTIVES: To evaluate the added value of the application of the liver-specific contrast phase of Gadobenate dimeglumine (Gd-BOPTA) for detection and characterization of liver lesions in 18F-FDG PET/MRI. METHODS: 41 patients with histologically confirmed solid tumors and known / suspected liver metastases or not classifiable lesions in 18F-FDG PET/CT were included in this study. All patients underwent a subsequent Gd-BOPTA enhanced 18F-FDG PET/MRI examination. MRI without liver-specific contrast phase (MRI1), MRI with liver-specific contrast phase (MRI2), 18F-FDG PET/MRI without liver-specific contrast phase (PET/MRI1) and with liver-specific contrast phase (PET/MRI2) were separately evaluated for suspect lesions regarding lesion dignity, characterization, conspicuity and confidence...
2017: PloS One
https://www.readbyqxmd.com/read/28680873/amino-acid-pet-and-mr-perfusion-imaging-in-brain-tumours
#11
REVIEW
Christian P Filss, Francesco Cicone, Nadim Jon Shah, Norbert Galldiks, Karl-Josef Langen
PURPOSE: Despite the excellent capacity of the conventional MRI to image brain tumours, problems remain in answering a number of critical diagnostic questions. To overcome these diagnostic shortcomings, PET using radiolabeled amino acids and perfusion-weighted imaging (PWI) are currently under clinical evaluation. The role of amino acid PET and PWI in different diagnostic challenges in brain tumours is controversial. METHODS: Based on the literature and experience of our centres in correlative imaging with PWI and PET using O-(2-[(18)F]fluoroethyl)-l-tyrosine or 3,4-dihydroxy-6-[(18)F]-fluoro-l-phenylalanine, the current role and shortcomings of amino acid PET and PWI in different diagnostic challenges in brain tumours are reviewed...
2017: Clinical and Translational Imaging: Reviews in Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28678258/-18-f-fluoroalkyl-azides-for-rapid-radiolabeling-and-re-investigation-of-their-potential-towards-in-vivo-click-chemistry
#12
Christoph Denk, Martin Wilkovitsch, Philipp Skrinjar, Dennis Svatunek, Severin Mairinger, Claudia Kuntner, Thomas Filip, Johannes Fröhlich, Thomas Wanek, Hannes Mikula
In recent years, radiofluorinated alkyl azides have been reported for click radiolabeling and pretargeted PET imaging, but only little is known about the biodistribution and metabolism of these compounds. In this work, we present a significantly improved procedure for the synthesis of [(18)F]fluoroethyl azide and reinvestigated this radiolabeled probe in detail showing poor stability and very restricted suitability for in vivo application. Therefore, modified low-molecular-weight [(18)F]fluoroalkyl azides were developed...
July 19, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28675598/mr-based-truncation-and-attenuation-correction-in-integrated-pet-mr-hybrid-imaging-using-huge-with-continuous-table-motion
#13
Maike E Lindemann, Mark Oehmigen, Jan O Blumhagen, Marcel Gratz, Harald H Quick
PURPOSE: The objective of this study was to introduce and evaluate a method for MR-based attenuation and truncation correction in phantom and patient measurements to improve PET quantification in PET/MR hybrid imaging. METHODS: The fully MR-based method HUGE (B0 Homogenization using gradient enhancement) provides field-of-view extension in MR imaging, which can be used for truncation correction and improved PET quantification in PET/MR hybrid imaging. The HUGE method in this recent implementation is combined with continuously moving table data acquisition to provide a seamless non-truncated whole-body data set of the outer patient contours to complete the established standard MR-based Dixon-VIBE data for attenuation correction...
July 4, 2017: Medical Physics
https://www.readbyqxmd.com/read/28675110/metabolic-regional-and-network-changes-in-alzheimer-s-disease-subtypes
#14
Karl Herholz, Cathleen Haense, Alex Gerhard, Matthew Jones, José Anton-Rodriguez, Shailendra Segobin, Julie S Snowden, Jennifer C Thompson, Christopher Kobylecki
Clinical variants of Alzheimer's disease (AD) include the common amnestic subtype as well as subtypes characterised by leading visual processing impairments or by multimodal neurocognitive deficits. We investigated regional metabolic patterns and networks between AD subtypes. The study comprised 9 age-matched controls and 25 patients with mild to moderate AD. Methods included clinical and neuropsychological assessment, high-resolution FDG PET and T1-weighted 3D MR imaging with PET-MR coregistration, grey matter segmentation, atlas-based regions-of-interest, linear mixed effects and regional correlation analysis...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28674847/a-new-integrated-dual-time-point-amyloid-pet-mri-data-analysis-method
#15
Diego Cecchin, Henryk Barthel, Davide Poggiali, Annachiara Cagnin, Solveig Tiepolt, Pietro Zucchetta, Paolo Turco, Paolo Gallo, Anna Chiara Frigo, Osama Sabri, Franco Bui
PURPOSE: In the initial evaluation of patients with suspected dementia and Alzheimer's disease, there is no consensus on how to perform semiquantification of amyloid in such a way that it: (1) facilitates visual qualitative interpretation, (2) takes the kinetic behaviour of the tracer into consideration particularly with regard to at least partially correcting for blood flow dependence, (3) analyses the amyloid load based on accurate parcellation of cortical and subcortical areas, (4) includes partial volume effect correction (PVEC), (5) includes MRI-derived topographical indexes, (6) enables application to PET/MRI images and PET/CT images with separately acquired MR images, and (7) allows automation...
July 4, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28668434/clinical-evaluation-of-whole-body-oncologic-pet-with-time-of-flight-and-point-spread-function-for-the-hybrid-pet-mr-system
#16
Kun Shang, Bixiao Cui, Jie Ma, Dongmei Shuai, Zhigang Liang, Floris Jansen, Yun Zhou, Jie Lu, Guoguang Zhao
PURPOSE: Hybrid positron emission tomography/magnetic resonance (PET/MR) imaging is a new multimodality imaging technology that can provide structural and functional information simultaneously. The aim of this study was to investigate the effects of the time-of-flight (TOF) and point-spread function (PSF) on small lesions observed in PET/MR images from clinical patient image sets. MATERIALS AND METHODS: This study evaluated 54 small lesions in 14 patients who had undergone (18)F-fluorodeoxyglucose (FDG) PET/MR...
August 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28668166/pet-mr-imaging-in-gynecologic-oncology
#17
REVIEW
Michael A Ohliger, Thomas A Hope, Jocelyn S Chapman, Lee-May Chen, Spencer C Behr, Liina Poder
MR imaging and PET using 2-Deoxy-2-[(18)F]fluoroglucose (FDG) are both useful in the evaluation of gynecologic malignancies. MR imaging is superior for local staging of disease whereas fludeoxyglucose FDG PET is superior for detecting distant metastases. Integrated PET/MR imaging scanners have great promise for gynecologic malignancies by combining the advantages of each modality into a single scan. This article reviews the technology behind PET/MR imaging acquisitions and technical challenges relevant to imaging the pelvis...
August 2017: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/28665183/one-stage-positron-emission-tomography-and-magnetic-resonance-imaging-to-assess-mesenchymal-stem-cell-survival-in-a-canine-model-of-intervertebral-disc-degeneration
#18
Donghua Hang, Fan Li, Wenjun Che, Xiaofeng Wu, Yao Wan, Jiandong Wang, Yanping Zheng
Intervertebral disc (IVD) degeneration is a major health problem. Although mesenchymal stem cells (MSCs) have been used to promote IVD regeneration, the actual survival time of implanted MSCs in IVDs has never been studied non-invasively and continuously in vivo. To investigate survival of implanted MSCs in vivo, this study used a canine model of degenerated IVD and MSCs transfected with a mutant herpes simplex type-1 virus thymidine kinase (HSV1-sr39tk) and labelled with magnetic iron oxide nanoparticles (MION)...
June 30, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/28662398/evaluation-of-ultrasmall-superparamagnetic-iron-oxide-uspio-enhanced-mri-with-ferumoxytol-to-quantify-arterial-wall-inflammation
#19
Loek P Smits, Feiko Tiessens, Kang He Zheng, Erik S Stroes, Aart J Nederveen, Bram F Coolen
BACKGROUND AND AIMS: Inflammation in atherosclerotic plaques is an important determinant of plaque vulnerability, and can be detected non-invasively using ultra-small superparamagnetic iron-oxide (USPIO) enhanced MRI. The aims of the current study were: 1) to determine whether ferumoxytol can be used for USPIO-MRI of atherosclerotic plaques, 2) to establish a protocol for quantitative USPIO-MRI of carotid artery plaques using ferumoxytol, and 3) to study the relation between USPIO uptake and plaque burden and (18)F-fluorodeoxyglucose (FDG) uptake (measured by (18)F-FDG PET/CT scan) in atherosclerotic plaques...
June 8, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28661060/decreased-glutamate-levels-in-patients-with-amnestic-mild-cognitive-impairment-an-slaser-proton-mr-spectroscopy-and-pib-pet-study
#20
Burcu Zeydan, Dinesh K Deelchand, Nirubol Tosakulwong, Timothy G Lesnick, Orhun H Kantarci, Mary M Machulda, David S Knopman, Val J Lowe, Clifford R Jack, Ronald C Petersen, Gülin Öz, Kejal Kantarci
BACKGROUND AND PURPOSE: Glutamate levels may be informative about the declining neuronal health in the central nervous system. We used an advanced proton MR spectroscopy ((1) H-MRS) protocol composed of semi-localization by adiabatic selective refocusing (sLASER) localization and FAST(EST)MAP shimming for detection of alterations in brain glutamate concentrations in patients with amnestic mild cognitive impairment. METHODS: Participants with amnestic mild cognitive impairment (n = 14; median age = 80) and age- and sex-matched clinically normal controls (n = 32; median age = 79) from the population-based Mayo Clinic Study of Aging were recruited prospectively to the 3T single-voxel (1) H-MRS study that examined metabolite changes in the posterior cingulate gyri...
June 29, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
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