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https://www.readbyqxmd.com/read/28534182/imaging-children-suffering-from-lymphoma-an-evaluation-of-different-18-f-fdg-pet-mri-protocols-compared-to-whole-body-dw-mri
#1
Julian Kirchner, Cornelius Deuschl, Bernd Schweiger, Ken Herrmann, Michael Forsting, Christian Buchbender, Gerald Antoch, Lale Umutlu
OBJECTIVES: The objectives of this study were to evaluate and compare the diagnostic potential of different PET/MRI reading protocols, entailing non-enhanced / contrast-enhanced and diffusion-weighted (18)F-FDG PET/MR imaging and whole-body diffusion-weighted MRI for lesion detection and determination of the tumor stage in pediatric lymphoma patients. METHODS: A total of 28 (18)F-FDG PET/MRI datasets were included for analysis of four different reading protocols: (1) PET/MRI utilizing sole unenhanced T2w and T1w imaging, (2) PET/MRI utilizing additional contrast enhanced sequences, (3) PET/MR imaging utilizing unenhanced, contrast enhanced and DW imaging or (4) WB-DW-MRI...
May 22, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28533937/a-phase-one-single-dose-open-label-clinical-safety-and-pet-mr-imaging-study-of-68-ga-dotatoc-in-healthy-volunteers
#2
Shadi A Esfahani, Stephanie Salcedo, Pedram Heidari, Onofrio A Catalano, Rachel Pauplis, Jacob Hesterman, James F Kronauge, Umar Mahmood
This prospective pilot study provides a dynamic whole body PET/MR image database, clinical safety, biodistribution profile and dosimetry of (68)Ga-DOTATOC in healthy subjects, to establish a baseline and standard reference for its use in diagnosis and treatment response evaluation among patients with somatostatin receptor expressing neoplastic diseases. Dynamic whole body PET/MR imaging was performed in 12 healthy subjects (male/female: 8/4) after injection of 242.39 ± 53.38 MBq (mean ± SD) (68)Ga-DOTATOC...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28533655/-18-f-fdg-pet-ct-in-localizing-additional-cns-lesion-in-a-case-of-langerhans-cell-histiocytosis-determining-accurate-extent-of-the-disease
#3
Shamim Ahmed Shamim, Sarthak Tripathy, Anirban Mukherjee, Chandrasekhar Bal, Madhavi Tripathi
Central nervous system involvement is a rare manifestation of Langerhans cell histiocytosis (LCH), with bone and skin lesions being more frequent. MR remains the investigation of choice for localizing brain lesions. However, due to poor sensitivity of MRI in detecting osseous and pulmonary lesions, it is not used routinely in staging purposes until and unless indicated. We hereby discuss a case of 6-year-old boy of LCH who was referred for 18-F-FDG PET/CT for staging and knowing the extent of the disease, but a lesion in hypothalamus was picked up incidentally on FDG PET-CT study that was confirmed by MRI...
April 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28527792/3d-cmro2-mapping-in-human-brain-with-direct-17-o-mri-comparison-of-conventional-and-proton-constrained-reconstructions
#4
Dmitry Kurzhunov, Robert Borowiak, Marco Reisert, Axel Joachim Krafft, Ali Caglar Özen, Michael Bock
Oxygen metabolism is altered in brain tumor regions and is quantified by the cerebral metabolic rate of oxygen consumption (CMRO2). Direct dynamic (17)O MRI with inhalation of isotopically enriched (17)O2 gas can be used to quantify CMRO2; however, pixel-wise CMRO2 quantification in human brain is challenging due to low natural abundance of (17)O isotope and, thus, the low signal-to-noise ratio (SNR) of (17)O MR images. To test the feasibility CMRO2 mapping at a clinical 3 T MRI system, a new iterative reconstruction was proposed, which uses the edge information contained in a co-registered (1)H gradient image to construct a non-homogeneous anisotropic diffusion (AD) filter...
May 17, 2017: NeuroImage
https://www.readbyqxmd.com/read/28523963/brain-hypoxia-mapping-in-acute-stroke-back-to-back-t2-mr-versus-18-f-fluoromisonidazole-pet-in-rodents
#5
Ulf Jensen-Kondering, Roido Mavanaki, Sohail Ejaz, Stephen J Sawiak, T Adrian Carpenter, Tim D Fryer, Franklin I Aigbirhio, David J Williamson, Jean-Claude Baron
Background Mapping the hypoxic brain in acute ischemic stroke has considerable potential for both diagnosis and treatment monitoring. PET using (18)F-fluoro-misonidazole (FMISO) is the reference method; however, it lacks clinical accessibility and involves radiation exposure. MR-based T2' mapping may identify tissue hypoxia and holds clinical potential. However, its validation against FMISO imaging is lacking. Here we implemented back-to-back FMISO-PET and T2' MR in rodents subjected to acute middle cerebral artery occlusion...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28516232/-cns-metabolism-in-high-risk-drug-abuse-german-version-insights-gained-from-1-h-and-31-p-mrs-and-pet
#6
REVIEW
S V Bodea
BACKGROUND: High-risk drug consumption is a considerable problem for public health actors in industrialised countries. The latest trends show a market tendency towards diversification and increasing demand for high-purity synthetic drugs. Whilst most consumers seek medical help after cannabis use, it is high-risk drugs like cocaine, heroin and amphetamines that account for most of the 1000 drug-related deaths that occur in Germany every year. PURPOSE: This article presents the most prominent in vivo cerebral metabolic information in cocaine, heroin and methamphetamine users provided by MRI spectroscopy and PET imaging...
May 17, 2017: Der Radiologe
https://www.readbyqxmd.com/read/28512714/comparison-of-the-diagnostic-accuracy-of-pet-mri-to-pet-ct-acquired-fdg-brain-exams-for-seizure-focus-detection-a-prospective-study
#7
Michael J Paldino, Erica Yang, Jeremy Y Jones, Nadia Mahmood, Andrew Sher, Wei Zhang, Shireen Hayatghaibi, Ramkumar Krishnamurthy, Victor Seghers
BACKGROUND: There is great interest in positron emission tomography (PET)/magnetic resonance (MR) as a clinical tool due to its capacity to provide diverse diagnostic information in a single exam. OBJECTIVE: The goal of this exam is to compare the diagnostic accuracy of PET/MR-acquired [F-18]2-fluoro-2-deoxyglucose (FDG) brain exams to that of PET/CT with respect to identifying seizure foci in children with localization-related epilepsy. MATERIALS AND METHODS: Institutional Review Board approval and informed consent were obtained for this Health Insurance Portability and Accountability Act-compliant, prospective study...
May 16, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28506641/guiding-multimodal-registration-with-learned-optimization-updates
#8
Benjamin Gutierrez-Becker, Diana Mateus, Loic Peter, Nassir Navab
In this paper, we address the multimodal registration problem from a novel perspective, aiming to predict the transformation aligning images directly from their visual appearance. We formulate the prediction as a supervised regression task, with joint image descriptors as input and the output are the parameters of the transformation that guide the moving image towards alignment. We model the joint local appearance with context aware descriptors that capture both local and global cues simultaneously in the two modalities, while the regression function is based on the gradient boosted trees method capable of handling the very large contextual feature space...
May 6, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28503729/fully-integrated-3d-high-resolution-multicontrast-abdominal-pet-mr-with-high-scan-efficiency
#9
Christoph Kolbitsch, Radhouene Neji, Matthias Fenchel, Andrew Mallia, Paul Marsden, Tobias Schaeffter
PURPOSE: To provide 3D multicontrast anatomical MR with high isotropic resolution and metabolic positron emission tomography (PET) images using a respiratory motion-compensated simultaneous PET-MR examination with high scan efficiency. THEORY AND METHODS: Standard abdominal PET-MR examinations combine MR data obtained during multiple breath-holds with free-breathing PET acquisitions, limiting the achievable image resolution and potentially causing misalignment errors between breath-hold and free-breathing data...
May 14, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28500751/radiological-biomarkers-for-diagnosis-in-psp-where-are-we-and-where-do-we-need-to-be
#10
REVIEW
Jennifer L Whitwell, Günter U Höglinger, Angelo Antonini, Yvette Bordelon, Adam L Boxer, Carlo Colosimo, Thilo van Eimeren, Lawrence I Golbe, Jan Kassubek, Carolin Kurz, Irene Litvan, Alexander Pantelyat, Gil Rabinovici, Gesine Respondek, Axel Rominger, James B Rowe, Maria Stamelou, Keith A Josephs
BACKGROUND: PSP is a pathologically defined neurodegenerative tauopathy with a variety of clinical presentations including typical Richardson's syndrome and other variant PSP syndromes. Our aim was to critically evaluate the degree to which structural, functional and molecular neuroimaging metrics fulfill criteria for diagnostic biomarkers of PSP. METHODS: We queried the PubMed, Cochrane, Medline, and PSYCInfo databases for original research articles published in English using postmortem diagnosis or NINDS-SPSP criteria as the diagnostic standard from 1996-2016...
May 13, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28500539/hybrid-pet-ct-and-pet-mri-imaging-of-vulnerable-coronary-plaque-and-myocardial-scar-tissue-in-acute-myocardial-infarction
#11
Stephanie Marchesseau, Aruni Seneviratna, A Therese Sjöholm, Daphne Liang Qin, Jamie X M Ho, Derek J Hausenloy, David W Townsend, A Mark Richards, John J Totman, Mark Y Y Chan
BACKGROUND: Following an acute coronary syndrome, combined CT and PET with (18)F-NaF can identify coronary atherosclerotic plaques that have ruptured or eroded. However, the processes behind (18)F-NaF uptake in vulnerable plaques remain unclear. METHODS AND RESULTS: Ten patients with STEMI were scanned after (18)F-NaF injection, for 75 minutes in a Siemens PET/MR scanner using delayed enhancement (LGE). They were then scanned in a Siemens PET/CT scanner for 10 minutes...
May 12, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28495008/a-fully-automatic-approach-for-multimodal-pet-and-mr-image-segmentation-in-gamma-knife-treatment-planning
#12
Leonardo Rundo, Alessandro Stefano, Carmelo Militello, Giorgio Russo, Maria Gabriella Sabini, Corrado D'Arrigo, Francesco Marletta, Massimo Ippolito, Giancarlo Mauri, Salvatore Vitabile, Maria Carla Gilardi
BACKGROUND AND OBJECTIVES: Nowadays, clinical practice in Gamma Knife treatments is generally based on MRI anatomical information alone. However, the joint use of MRI and PET images can be useful for considering both anatomical and metabolic information about the lesion to be treated. In this paper we present a co-segmentation method to integrate the segmented Biological Target Volume (BTV), using [(11)C]-Methionine-PET (MET-PET) images, and the segmented Gross Target Volume (GTV), on the respective co-registered MR images...
June 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28490932/contextualizing-the-use-of-oncologic-imaging-within-treatment-phases-imaging-trends-and-modality-preferences-2000-2014
#13
T P Copeland, J M Creasman, D J Seidenwurm, B L Franc
BACKGROUND: In the present study, we retrospectively evaluated the use of tomographic imaging in adult cancer patients to clarify how recent growth plateaus in the use of tomographic imaging in the United States might have affected oncologic imaging during the same period. METHODS: At a U.S. academic cancer centre, 12,059 patients with dates of death from January 2000 through December 2014 were identified. Imaging was restricted to brain and body computed tomography (ct), brain and body magnetic resonance (mr), and body positron-emission tomography (pet) with and without superimposed ct...
April 2017: Current Oncology
https://www.readbyqxmd.com/read/28481792/multiparametric-evaluation-of-treatment-response-to-neoadjuvant-chemotherapy-in-breast-cancer-using-integrated-pet-mr
#14
Jane Wang, Tiffany Ting-Fang Shih, Ruoh-Fang Yen
PURPOSE: The aim of this study was to investigate whether integrated PET/MR system can predict the treatment response to neoadjuvant chemotherapy (NAC) early in the course of breast cancer treatment. METHODS: Fourteen women with newly diagnosed invasive breast cancer (median age, 54.5 years) were recruited. Each participant underwent 2 PET/MR studies. Study 1 was pre-NAC; study 2 was early in NAC treatment (after the first or second cycle). PET parameters included SUVmax and total lesion glycolysis (TLG)...
May 6, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28481080/quantitative-molecular-imaging-with-a-single-gd-based-contrast-agent-reveals-specific-tumor-binding-and-retention-in-vivo
#15
Mette L Johansen, Ying Gao, Melanie A Hutnick, Sonya E L Craig, Jonathan K Pokorski, Chris A Flask, Susann M Brady-Kalnay
Magnetic resonance imaging (MRI) has become an indispensable tool in the diagnosis and treatment of many diseases, especially cancer. However, the poor sensitivity of MRI relative to other imaging modalities, such as PET, has hindered the development and clinical use of molecular MRI contrast agents that could provide vital diagnostic information by specifically locating a molecular target altered in the disease process. This work describes the specific and sustained in vivo binding and retention of a protein tyrosine phosphatase mu (PTPμ)-targeted, molecular magnetic resonance (MR) contrast agent with a single gadolinium (Gd) chelate using a quantitative MRI T1 mapping technique in glioma xenografts...
May 22, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28480872/estimation-of-arterial-input-by-a-noninvasive-image-derived-method-in-brain-h2-15-o-pet-study-confirmation-of-arterial-location-using-mr-angiography
#16
Muhammad Muinul Islam, Tetsuya Tsujikawa, Tetsuya Mori, Yasushi Kiyono, Hidehiko Okazawa
A noninvasive method to estimate input function directly from H2(15)O brain PET data for measurement of cerebral blood flow (CBF) was proposed in this study. The image derived input function (IDIF) method extracted the time-activity curves (TAC) of the major cerebral arteries at the skull base from the dynamic PET data. The extracted primordial IDIF showed almost the same radioactivity as the arterial input function (AIF) from sampled blood at the plateau part in the later phase, but significantly lower radioactivity in the initial arterial phase compared with that of AIF-TAC...
May 8, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28480541/response-assessment-of-stereotactic-body-radiation-therapy-using-dynamic-contrast-enhanced-integrated-mr-pet-in-non-small-cell-lung-cancer-patients
#17
Yu-Sen Huang, Jenny Ling-Yu Chen, Feng-Ming Hsu, Jei-Yie Huang, Wei-Chun Ko, Yi-Chang Chen, Fu-Shan Jaw, Ruoh-Fang Yen, Yeun-Chung Chang
PURPOSE: To evaluate the response in patients undergoing SBRT using dynamic contrast-enhanced (DCE) integrated magnetic resonance positron emission tomography (MR-PET). Stereotactic body radiation therapy (SBRT) is efficacious as a front-line local treatment for non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: We prospectively enrolled 19 lung tumors in 17 nonmetastatic NSCLC patients who were receiving SBRT as a primary treatment. They underwent DCE-integrated 3T MR-PET before and 6 weeks after SBRT...
May 8, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28473601/american-college-of-radiology-and-society-of-nuclear-medicine-and-molecular-imaging-joint-credentialing-statement-for-pet-mr-imaging-body
#18
Rathan M Subramaniam, Hossein Jadvar, Patrick M Colletti, Alexander Guimaraes, Rao Gullapali, Andrei H Iagaru, Jonathan McConathy, Carolyn C Meltzer, Helen Nadel, Richard B Noto, Alan B Packard, Eric Rohren, M Elizabeth Oates
This joint statement is intended to guide credentialing bodies that privilege physicians to oversee the performance of and participation in the interpretation of PET/MR imaging in adult and pediatric patients in the United States.
May 4, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28473594/evaluation-of-sinus-edge-corrected-zte-based-attenuation-correction-in-brain-pet-mri
#19
Jaewon Yang, Florian Wiesinger, Sandeep Kaushik, Dattesh Shanbhag, Thomas A Hope, Peder E Z Larson, Youngho Seo
Purpose: In brain positron emission tomography/magnetic resonance imaging (PET/MRI), the major challenge of zero-echo-time (ZTE)-based attenuation correction (ZTAC) is the misclassification of air/tissue/bone mixtures or their boundaries. Our study aimed to evaluate a sinus/edge corrected (SEC) ZTAC (ZTACSEC), relative to an "uncorrected (UC)" ZTAC (ZTACUC) and a computed tomography (CT) atlas-based attenuation correction (ATAC). Materials and Methods: Whole-body fluorodeoxyglucose PET/MRI scans were performed for twelve patients, following PET/CT scans...
May 4, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28473286/characterization-of-a-novel-murine-model-for-spontaneous-hemorrhagic-stroke-using-in-vivo-pet-and-mr-multiparametric-imaging
#20
Salvador Castaneda Vega, Christine Weinl, Carsten Calaminus, Lisa Wang, Maren Harant, Walter Ehrlichmann, Dennis Thiele, Ursula Kohlhofer, Gerald Reischl, Johann-Martin Hempel, Ulrike Ernemann, Leticia Quintanilla Martinez, Alfred Nordheim, Bernd J Pichler
The clinical use of Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) has proven to be a strong diagnostic tool in the field of neurology. The reliability of these methods to confirm clinical diagnoses has guided preclinical research to utilize these techniques for the characterization of animal disease models. Previously, we demonstrated that an endothelial cell-specific ablation of the murine Serum Response Factor (Srf(iECKO)) results in blood brain barrier (BBB) breakdown and hemorrhagic stroke...
May 1, 2017: NeuroImage
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