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Onofrio Antonio Catalano, Vincent Wu, Umar Mahmood, Alberto Signore, Mark Vangel, Andrea Soricelli, Marco Salvatore, Debra Gervais, Bruce R Rosen
This study investigates the performance of PET/MR versus each sub-modality alone in the assessment of active inflammation in patients with Crohn disease, when compared to surgery as standard of reference. Sensitivity for detecting active inflammation was 91.5% for PET, 80% for MR, and 88% for PET/MR. Specificity for active inflammation was 74% for PET, 87% for MR, and 93% for PET/MR. Diagnostic accuracy was 84% for PET, 83% for MR, and 91% for PET/MR. In conclusion, PET/MR is significantly more accurate than either sub-modality alone and more specific than PET alone in the detection of active inflammation in patients with Crohn disease...
2018: American Journal of Nuclear Medicine and Molecular Imaging
Sangeeta Taneja, Amarnath Jena, Rajesh Taneja, Aru Singh, Aashim Ahuja
OBJECTIVE: The purpose of this study is to assess whether temporal changes in68 Ga-prostate-specific membrane antigen (PSMA)-HBED-CC uptake and multiparametric MRI parameters derived using PET/MRI can aid in characterization of benign and malignant prostate lesions. MATERIALS AND METHODS: Thirty-five men with 29 malignant and six benign prostate lesions undergoing complete clinical workup including histologic analysis were enrolled for this retrospective study. All had undergone simultaneous whole-body68 Ga-PSMAHBED-CC PET/MRI...
March 12, 2018: AJR. American Journal of Roentgenology
Patrick Krumm, Stefanie Mangold, Sergios Gatidis, Konstantin Nikolaou, Felix Nensa, Fabian Bamberg, Christian la Fougère
Combined PET/MRI is a novel imaging method integrating the advances of functional and morphological MR imaging with PET applications that include assessment of myocardial viability, perfusion, metabolism of inflammatory tissue and tumors, as well as amyloid deposition imaging. As such, PET/MRI is a promising tool to detect and characterize ischemic and non-ischemic cardiomyopathies. To date, the greatest benefit may be expected for diagnostic evaluation of systemic diseases and cardiac masses that remain unclear in cardiac MRI, as well as for clinical and scientific studies in the setting of ischemic cardiomyopathies...
March 10, 2018: Japanese Journal of Radiology
Daniele A Pizzuto, Julian Müller, Urs Mühlematter, Niels J Rupp, Antonia Töpfer, Ashkan Mortezavi, Hannes Nagel, Benedikt Kranzbühler, Daniel Eberli, Irene A Burger
PURPOSE: Given the good correlation between PSMA expression and intraglandular tumour aggressiveness based on immunohistochemistry, there is increasing interest in68 Ga-PSMA-11 PET/MRI for staging prostate cancer (PCA). Therefore, accurate knowledge of prostate anatomy as well as normal distribution of PSMA within the prostate gland is becoming essential. The aim of this study was to investigate the physiological intraprostatic distribution of68 Ga-PSMA-11. METHODS: We retrospectively analysed all patients who underwent a staging68 Ga-PSMA-11 PET/MRI scan between June 2016 and January 2018 for high-risk PCA, underwent radical prostatectomy in our institution, and gave written consent for further data analysis...
March 9, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Richard Manber, Kris Thielemans, Brian F Hutton, Simon Wan, Francesco Fraioli, Anna Barnes, Sebastien Ourselin, Simon Arridge, David Atkinson
In Positron Emission Tomography (PET) imaging, patient motion due to respiration can lead to artefacts and blurring, in addition to quantification errors. The integration of PET imaging with Magnetic Resonance (MR) imaging in PET/MR scanners provides spatially aligned complementary clinical information, and allows the use of high spatial resolution and high contrast MR images to monitor and correct motion-corrupted PET data. We validate our PET respiratory motion correction methodology based on a joint PET-MR motion model, on a patient cohort, showing it can improve lesion detectability and quantitation, and reduce image artefacts...
March 9, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Tracy Ssali, Udunna C Anazodo, Jonathan D Thiessen, Frank S Prato, Keith St Lawrence
While positron emission tomography (PET) with15 O-water is the gold standard for imaging cerebral blood flow (CBF), quantification requires measuring the arterial input function (AIF), which is an invasive and noisy procedure. To circumvent this problem, we propose a non-invasive PET/ magnetic resonance (MR) approach that eliminates the need to measure the AIF by using global CBF determined by phase-contrast (PC) magnetic resonance imaging (MRI) as a reference region. Not only is this approach non-invasive, it adds no additional imaging time as PC MRI and15 O-water PET are acquired simultaneously...
March 9, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Esma A Akin, Elsa Stephen Kuhl, Robert K Zeman
All women, during their lifetime, are at risk of developing some form of gynecologic malignancy. The role of FDG-PET/CT has become more established in the management of gynecologic malignancies in the last decade. In this article, we will review the role of FDG-PET/CT in endometrial, cervical, ovarian, and vaginal cancer, by highlighting its strengths and limitations. While the role in initial or pre-operative staging for FDG-PET/CT is controversial, it allows noninvasive detection of equivocal or distant metastases, may alter stage and prognosis, and can guide or help eliminate unnecessary interventions that may not be beneficial...
March 8, 2018: Abdominal Radiology
Nasim Sheikh-Bahaei, S Ahmad Sajjadi, Roido Manavaki, Mary McLean, John T O'Brien, Jonathan H Gillard
OBJECTIVES: To determine if the level of metabolites in MR Spectroscopy (MRS) is a representative marker of underlying pathological changes identified in PET images in Alzheimer's disease (AD). METHODS: We performed PET-guided MRS in cases of probable AD, Mild Cognitive Impairment (MCI) and healthy controls (HC). All participants were imaged by11 C-Pittsburgh Compound B (11 C-PiB) and18 F-fluorodeoxy-glucose (18 F-FDG)-PET followed by 3T MRS. PET images were assessed both visually and using standardized uptake value ratios (SUVR)...
March 8, 2018: Annals of Neurology
Kevin T Chen, Stephanie Salcedo, Daniel B Chonde, David Izquierdo-Garcia, Michael A Levine, Julie C Price, Bradford C Dickerson, Ciprian Catana
BACKGROUND: Subject motion in positron emission tomography (PET) studies leads to image blurring and artifacts; simultaneously acquired magnetic resonance imaging (MRI) data provides a means for motion correction (MC) in integrated PET/MRI scanners. PURPOSE: To assess the effect of realistic head motion and MR-based MC on static [18 F]-fluorodeoxyglucose (FDG) PET images in dementia patients. STUDY TYPE: Observational study. POPULATION: Thirty dementia subjects were recruited...
March 8, 2018: Journal of Magnetic Resonance Imaging: JMRI
Ismini C Mainta, Maria I Vargas, Sara Trombella, Giovanni B Frisoni, Paul G Unschuld, Valentina Garibotto
Multiple factors, namely amyloid, tau, inflammation, metabolic, and perfusion changes, contribute to the cascade of neurodegeneration and functional decline occurring in Alzheimer's disease (AD). These molecular and cellular processes and related functional and morphological changes can be visualized in vivo by two imaging modalities, namely positron emission tomography (PET) and magnetic resonance imaging (MRI). These imaging biomarkers are now part of the diagnostic algorithm and of particular interest for patient stratification and targeted drug development...
2018: Methods in Molecular Biology
Manish N Shah, Anish Mitra, Manu S Goyal, Abraham Z Snyder, Jing Zhang, Joshua S Shimony, David D Limbrick, Marcus E Raichle, Matthew D Smyth
PURPOSE: Temporal lobe epilepsy (TLE) affects resting state brain networks in adults. This study aims to correlate resting state functional MRI (rsMRI) signal latency in pediatric TLE patients with their laterality. METHODS: From 2006 to 2016, 26 surgical TLE patients (12 left, 14 right) with a mean age of 10.7 years (range 0.9-18) were prospectively studied. Preoperative rsMRI was obtained in patients with concordant lateralizing structural MRI, EEG, and PET studies...
March 6, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Antoine Verger, Christian P Filss, Philipp Lohmann, Gabriele Stoffels, Michael Sabel, Hans-J Wittsack, Elena Rota Kops, Norbert Galldiks, Gereon R Fink, Nadim J Shah, Karl-Josef Langen
OBJECTIVES: To compare the diagnostic performance of O-(2-18 F-fluoroethyl)-L-tyrosine (18 F-FET) PET and perfusion-weighted MR imaging (PWI) for the diagnosis of progressive or recurrent glioma. METHODS: Thirty-two pretreated gliomas (25 progressive or recurrent tumors, 7 treatment-related changes, TRC) were investigated with18 F-FET PET and PWI using a hybrid PET/MR scanner. Volumes of interest (VOIs) with a diameter of 16 mm were centered upon the maximum of abnormality in the tumor area in PET and PWI maps (rCBV, rCBF, MTT) and the contralateral unaffected hemisphere...
March 3, 2018: World Neurosurgery
Sunghoon Park, Joon-Kee Yoon, Nam-Su Chung, Sang Hyun Kim, Jinwoo Hwang, Hyun Young Lee, Kyu-Sung Kwack
OBJECTIVE: To investigate the relationship between intravoxel incoherent motion (IVIM) diffusion-weighted MR imaging (DWI) parameters and 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) metabolic parameters in patients with vertebral bone metastases. METHODS: Nineteen patients with vertebral bone metastases were retrospectively included in this institutional review board-approved study. All patients underwent IVIM DWI and 18F-FDG PET/CT before treatment...
March 6, 2018: British Journal of Radiology
Doortje C Engel, Simone Peraio, Sotirios Bisdas, Jens Schittenhelm, Marcos Tatagiba
No abstract text is available yet for this article.
March 6, 2018: Journal of Neurosurgical Sciences
Abdullah A Alharbi, Fahad M Alshehri, Abdulrahman A Albatly, Bert-Ram Sah, Christoph Schmid, Gerhard F Huber, Martin W Huellner
PURPOSE: The aim of the study was to investigate the relationship between [18 F]fluoromethyl-dimethyl-2-hydroxyethylammonium ([18 F]FCh) positron emission tomography (PET) parameters, laboratory parameters, and postoperative histopathological results in patients with primary hyperparathyroidism (pHPT) due to parathyroid adenomas. PROCEDURES: This retrospective study was conducted in 52 patients with biochemically proven pHPT. [18 F]FCh-PET parameters (maximum standardized uptake value: SUVmax) in early phase (after 2 min) and late phase (after 50 min), metabolic volume, and adenoma-to-background ratio (ABR), preoperative laboratory results (PTH and serum calcium concentration), and postoperative histopathology (location, size, volume, and weight of adenoma) were assessed...
March 5, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
Madhavi Tripathi, Atin Kumar, Chandrasekhar Bal
Neuroimaging (NI) in Parkinson's disease (PD) includes functional techniques like positron emission tomography (PET) and single photon emission computed tomography (SPECT), and morphological imaging using magnetic resonance imaging (MRI) and transcranial sonography to probe different aspects of the neurobiology of PD. Changes in neurotransmitters in various regions of the brain and their influence on brain networks is the basis for the motor symptoms of PD which are interrogated by NI. The recent Movement Disorders Society Clinical Diagnostic Criteria for PD (MDS-PD) have included the results of a few of these neuroimaging techniques to serve as single supportive criteria or absolute exclusion criteria for the diagnosis of PD...
March 2018: Neurology India
Sheng-Chieh Chan, Chih-Hua Yeh, Tzu-Chen Yen, Shu-Hang Ng, Joseph Tung-Chieh Chang, Chien-Yu Lin, Tsang Yen-Ming, Kang-Hsing Fan, Bing-Shen Huang, Cheng-Lung Hsu, Kai-Ping Chang, Hung-Ming Wang, Chun-Ta Liao
PURPOSE: Both head and neck magnetic resonance imaging (MRI) and 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) play a crucial role in the staging of primary nasopharyngeal carcinoma (NPC). In this study, we sought to prospectively investigate the clinical utility of simultaneous whole-body 18F-FDG PET/MRI for primary staging of NPC patients. METHODS: We examined 113 patients with histologically confirmed NPC who underwent pretreatment, simultaneous whole-body PET/MRI and PET/CT for primary tumor staging...
March 3, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Alexey Surov, Leonard Leifels, Hans Jonas Meyer, Karsten Winter, Osama Sabri, Sandra Purz
AIM: To analyze associations between parameters of positron-emission tomography (PET) and histogram analysis values of dynamic contrast-enhanced (DCE) imaging in patients with head and neck squamous cell carcinoma (HNSCC). PATIENTS AND METHODS: Overall, 28 patients with primary HNSCC of different localizations were involved.18 F-FDG-PET/CT and DCE MR imaging were performed for all patients. Histogram analysis parameters of DCE MRI were calculated. Spearman's correlation coefficient was used to analyze the associations between investigated parameters...
March 2018: Anticancer Research
Charles M Laymon, Davneet S Minhas, Carl R Becker, Cristy Matan, Matthew J Oborski, Julie C Price, James M Mountz
PURPOSE: In dual modality positron emission tomography (PET)/magnetic resonance imaging (MRI), attenuation correction (AC) methods are continually improving. Although a new AC can sometimes be generated from existing MR data, its application requires a new reconstruction. We evaluate an approximate 2D projection method that allows offline image-based reprocessing. PROCEDURE: 2-Deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG) brain scans were acquired (Siemens HR+) for six subjects...
February 27, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
Tetsuya Tsujikawa, Norihiko Narita, Masafumi Kanno, Tetsuji Takabayashi, Shigeharu Fujieda, Hidehiko Okazawa
The American Joint Committee on Cancer (AJCC) released the 8th edition of the AJCC cancer staging manual in 2017 that includes significant modifications from the 7th edition in the sections on oral cavity cancer (OCC) and oropharyngeal cancer (OPC). These highlights comprise the incorporation of the depth of invasion and exclusion of extrinsic tongue muscle involvement in the T staging of OCC, the separation of OPC staging based on the high-risk human papilloma virus status, and the inclusion of extranodal extension in N staging...
February 27, 2018: Annals of Nuclear Medicine
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