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https://www.readbyqxmd.com/read/28336781/quantitative-evaluation-of-two-scatter-correction-techniques-for-18-f-fdg-brain-pet-mr-imaging-in-regard-to-mr-based-attenuation-correction
#1
Jarmo Teuho, Virva Saunavaara, Tuula Tolvanen, Terhi Tuokkola, Antti Karlsson, Jouni Tuisku, Mika Teräs
In positron emission tomography (PET), corrections for photon scatter and attenuation are essential for visual and quantitative consistency. Magnetic resonance attenuation correction (MRAC) is generally conducted by image segmentation and assignment of discrete attenuation coefficients, which offers limited accuracy compared to computed tomography attenuation correction (CTAC). Potential inaccuracies in MRAC may affect scatter correction, as the attenuation image (µ-map) is used in single scatter simulation (SSS) to calculate the scatter estimate...
March 23, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28321471/feasibility-of-in-vivo-18-f-florbetaben-pet-mr-imaging-of-human-carotid-amyloid-%C3%AE
#2
Jan Bucerius, Henryk Barthel, Solveig Tiepolt, Peter Werner, Judith C Sluimer, Joachim E Wildberger, Marianne Patt, Swen Hesse, Hermann-Josef Gertz, Erik A L Biessen, Felix M Mottaghy, Osama Sabri
PURPOSE: Amyloid-beta (Aβ) peptides are involved in the inflammatory pathology of atherosclerosis. (18)F-Florbetaben is a PET tracer for clinical imaging of cerebral Aβ plaques in Alzheimer's disease (AD). We sought to determine whether specific uptake of (18)F-florbetaben in the carotid arteries can be identified using a fully integrated hybrid PET/MRI system and whether this uptake is associated with clinical cardiovascular disease (CVD) risk factors. METHODS: Carotid (18)F-florbetaben uptake was quantified as the mean of the maximum target-to-background ratio (meanTBRmax) in 40 cognitively impaired subjects (age 68...
March 21, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28321246/medical-image-fusion-based-on-feature-extraction-and-sparse-representation
#3
Yin Fei, Gao Wei, Song Zongxi
As a novel multiscale geometric analysis tool, sparse representation has shown many advantages over the conventional image representation methods. However, the standard sparse representation does not take intrinsic structure and its time complexity into consideration. In this paper, a new fusion mechanism for multimodal medical images based on sparse representation and decision map is proposed to deal with these problems simultaneously. Three decision maps are designed including structure information map (SM) and energy information map (EM) as well as structure and energy map (SEM) to make the results reserve more energy and edge information...
2017: International Journal of Biomedical Imaging
https://www.readbyqxmd.com/read/28317128/comparison-of-dce-mri-kinetic-parameters-and-fmiso-pet-uptake-parameters-in-head-and-neck-cancer-patients
#4
Urban Simoncic, Sara Leibfarth, Stefan Welz, Nina Schwenzer, Holger Schmidt, Gerald Reischl, Christina Pfannenberg, Christian la Fougère, Konstantin Nikolaou, Daniel Zips, Daniela Thorwarth
PURPOSE: Tumour hypoxia is a major cause of radiation resistance, often present in various solid tumours. Dynamic [(18) F]-fluoromisonidazole (FMISO) PET imaging is able to reliably assess tumour hypoxia. Comprehensive characterization of tumour microenvironment through FMISO-PET and dynamic contrast enhanced (DCE) MR multimodality imaging might be a valuable alternative to the dynamic FMISO-PET acquisition. The aim of this work was to explore the correlation between the FMISO-PET and DCE-MRI kinetic parameters...
March 20, 2017: Medical Physics
https://www.readbyqxmd.com/read/28314275/relationship-between-ktrans-and-k1-with-simultaneous-versus-separate-mr-pet-in-rabbits-with-vx2-tumors
#5
Kyung Hee Lee, Seung Kwan Kang, Jin Mo Goo, Jae Sung Lee, Gi Jeong Cheon, Seongho Seo, Eui Jin Hwang
BACKGROUND/AIM: To compare the relationship between Ktrans from DCE-MRI and K1 from dynamic (13)N-NH3-PET, with simultaneous and separate MR/PET in the VX-2 rabbit carcinoma model. MATERIALS AND METHODS: MR/PET was performed simultaneously and separately, 14 and 15 days after VX-2 tumor implantation at the paravertebral muscle. The Ktrans and K1 values were estimated using an in-house software program. The relationships between Ktrans and K1 were analyzed using Pearson's correlation coefficients and linear/non-linear regression function...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28306727/biodistribution-and-pet-imaging-of-pharmacokinetics-of-manganese-in-mice-using-manganese-52
#6
A Lake Wooten, Tolulope A Aweda, Benjamin C Lewis, Rebecca B Gross, Suzanne E Lapi
Manganese is essential to life, and humans typically absorb sufficient quantities of this element from a normal healthy diet; however, chronic, elevated ingestion or inhalation of manganese can be neurotoxic, potentially leading to manganism. Although imaging of large amounts of accumulated Mn(II) is possible by MRI, quantitative measurement of the biodistribution of manganese, particularly at the trace level, can be challenging. In this study, we produced the positron-emitting radionuclide 52Mn (t1/2 = 5.6 d) by proton bombardment (Ep<15 MeV) of chromium metal, followed by solid-phase isolation by cation-exchange chromatography...
2017: PloS One
https://www.readbyqxmd.com/read/28306418/an-mrs-and-pet-guided-biopsy-tool-for-intraoperative-neuronavigational-systems
#7
Matthew Grech-Sollars, Babar Vaqas, Gerard Thompson, Tara Barwick, Lesley Honeyfield, Kevin O'Neill, Adam D Waldman
OBJECTIVE Glioma heterogeneity and the limitations of conventional structural MRI for identifying aggressive tumor components can limit the reliability of stereotactic biopsy and, hence, tumor characterization, which is a hurdle for developing and selecting effective treatment strategies. In vivo MR spectroscopy (MRS) and PET enable noninvasive imaging of cellular metabolism relevant to proliferation and can detect regions of more highly active tumor. Here, the authors integrated presurgical PET and MRS with intraoperative neuronavigation to guide surgical biopsy and tumor sampling of brain gliomas with the aim of improving intraoperative tumor-tissue characterization and imaging biomarker validation...
March 17, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28290393/hybrid-pet-mr-imaging-for-evaluation-of-recurrence-in-gliomas-standard-of-care-or-luxury
#8
B R Mittal, Shashank Singh
No abstract text is available yet for this article.
March 2017: Neurology India
https://www.readbyqxmd.com/read/28290392/potential-for-differentiation-of-glioma-recurrence-from-radionecrosis-using-integrated-18-f-fluoroethyl-l-tyrosine-fet-positron-emission-tomography-magnetic-resonance-imaging-a-prospective-evaluation
#9
Shanti K Sogani, Amarnath Jena, Sangeeta Taneja, Aashish Gambhir, Anil K Mishra, Maria M D'Souza, Sapna M Verma, Puja P Hazari, Pradeep Negi, Ganesh K R Jadhav
PURPOSE: To assess the utility of 18F-fluoroethyl-L-tyrosine (FET) positron emission tomography/magnetic resonance imaging (PET/MRI) in distinguishing recurrence from radionecrosis. MATERIALS AND METHODS: Thirty-two patients (25 males, 7 females) of glioma who had already undergone surgery/chemoradiotherapy and had enhancing brain lesions suspicious of recurrence were evaluated using integrated 18F-FET PET/MRI, and followed up with histopathology or clinical follow-up and/or MRI/PET/MRI imaging...
March 2017: Neurology India
https://www.readbyqxmd.com/read/28280965/radiosynthesis-and-first-in-human-pet-mri-evaluation-with-clinical-grade-18-f-ftc-146
#10
Bin Shen, Jun Hyung Park, Trine Hjørnevik, Peter W Cipriano, Daehyun Yoon, Praveen K Gulaka, Dawn Holly, Deepak Behera, Bonnie A Avery, Sanjiv S Gambhir, Christopher R McCurdy, Sandip Biswal, Frederick T Chin
PURPOSE: Sigma-1 receptors (S1Rs) play an important role in many neurological disorders. Simultaneous positron emission tomography (PET)/magnetic resonance imaging (MRI) with S1R radioligands may provide valuable information for diagnosing and guiding treatment for these diseases. Our previously reported S1R radioligand, [(18)F]FTC-146, demonstrated high affinity for the S1R (K i = 0.0025 nM) and excellent selectivity for the S1R over the sigma-2 receptor (S2Rs; K i = 364 nM) across several species (from mouse to non-human primate)...
March 9, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28267530/evaluation-of-pet-and-mr-datasets-in-integrated-18f-fdg-pet-mri-a-comparison-of-different-mr-sequences-for-whole-body-restaging-of-breast-cancer-patients
#11
Johannes Grueneisen, Lino Morris Sawicki, Axel Wetter, Julian Kirchner, Sonja Kinner, Bahriye Aktas, Michael Forsting, Verena Ruhlmann, Lale Umutlu
OBJECTIVES: To investigate the diagnostic value of different MR sequences and 18F-FDG PET data for whole-body restaging of breast cancer patients utilizing PET/MRI. METHODS: A total of 36 patients with suspected tumor recurrence of breast cancer based on clinical follow-up or abnormal findings in follow-up examinations (e.g. CT, MRI) were prospectively enrolled in this study. All patients underwent a PET/CT and subsequently an additional PET/MR scan. Two readers were instructed to identify the occurrence of a tumor relapse in subsequent MR and PET/MR readings, utilizing different MR sequence constellations for each session...
April 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28262272/pet-mr-imaging-of-pelvic-malignancies
#12
Axel Wetter, Johannes Grueneisen, Lale Umutlu
Integrated PET/MRI is a new technology which allows simultaneous acquisition of positron emission tomography and magnetic resonance imaging data during one examination. The technique appears to be particularly appropriate for oncologic imaging of female and male pelvic malignancies, as these entities demand a high soft tissue contrast and might be further assessed metabolically with PET. The review article highlights recent developments of integrated PET/MRI in pelvic malignancies.
February 20, 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28258444/response-assessment-of-bevacizumab-therapy-in-gbm-with-integrated-11c-met-pet-mri-a-feasibility-study
#13
Cornelius Deuschl, Christoph Moenninghoff, Sophia Goericke, Julian Kirchner, Susanne Köppen, Ina Binse, Thorsten D Poeppel, Harald H Quick, Michael Forsting, Lale Umutlu, Ken Herrmann, Joerg Hense, Marc Schlamann
BACKGROUND: The objective of this study was to evaluate the potential of integrated 11C-MET PET/MR for response assessment of relapsed glioblastoma (GBM) receiving bevacizumab treatment. METHODS: Eleven consecutive patients with relapsed GBM were enrolled for an integrated 11C-MET PET/MRI at baseline and at follow-up. Treatment response for MRI was evaluated according to Response Assessment in Neuro-oncology (RANO) criteria and integrated 11C-MET PET was assessed by the T/N ratio...
March 3, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28258206/the-role-of-radionuclide-imaging-in-epilepsy-part-2-epilepsy-syndromes
#14
REVIEW
Ajay Kumar, Harry T Chugani
PET and SPECT can play an important role in the evaluation of various epileptic syndromes, particularly those with unknown causes, by revealing various underlying abnormalities that may not be fully appreciated from MR imaging studies. In some cases, PET and SPECT provide crucial data that guide surgical resections of the epileptogenic zone for medically refractory epilepsy. In other cases, these neuroimaging modalities preclude a surgical option and can guide genetic studies. Longitudinal PET and SPECT studies may increase our understanding of the etiopathogenesis of epilepsy syndromes and provide a clearer picture of the natural history of neurologic progression...
March 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28258205/the-role-of-radionuclide-imaging-in-epilepsy-part-1-sporadic-temporal-and-extratemporal-lobe-epilepsy
#15
REVIEW
Ajay Kumar, Harry T Chugani
Epilepsy is one of the most common yet diverse neurologic disorders, affecting almost 1%-2% of the population. Presently, radionuclide imaging such as PET and SPECT is not used in the primary diagnosis or evaluation of recent-onset epilepsy. However, it can play a unique and important role in certain specific situations, such as in noninvasive presurgical localization of epileptogenic brain regions in intractable-seizure patients being considered for epilepsy surgery. Radionuclide imaging can be particularly useful if MR imaging is either negative for lesions or shows several lesions of which only 1 or 2 are suspected to be epileptogenic and if electroencephalogram changes are equivocal or discordant with the structural imaging...
March 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28254872/pet-mri-for-oncological-brain-imaging-a-comparison-of-standard-mr-based-attenuation-corrections-with-a-novel-model-based-approach-for-the-siemens-mmr-pet-mr-system
#16
Ivo Rausch, Lucas Rischka, Claes N Ladefoged, Julia Furtner, Matthias Fenchel, Andreas Hahn, Rupert Lanzenberger, Marius E Mayerhoefer, Tatjana Traub-Weidinger, Thomas Beyer
To compare attenuation correction (AC) approaches for positron emission tomography/magnetic resonance imaging (PET/MRI) in clinical neuro-oncology. Methods: Forty-nine PET/MRI brain scans were included: brain tumor studies using (18)F-FET (n = 31) and 68-Ga-DOTANOC (n = 7) and studies of healthy subjects using (18)F-FDG (n = 11). For each subject, MR-based AC maps (MR-AC) were acquired using the standard DIXON- (DIXON) and UTE-based (UTE) approaches. A third MR-AC was calculated using a model-based, post-processing approach to account for bone attenuation values (BD, non-commercial prototype software by Siemens Healthcare)...
March 2, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28254864/arterial-co2-as-a-potent-coronary-vasodilator-a-preclinical-pet-mr-validation-study-with-implications-for-cardiac-stress-testing
#17
Hsin-Jung Yang, Damini Dey, Jane Sykes, Michael Klein, John Butler, Michael Kovacs, Olivia Sobczyk, Behzad Sharif, Xiaoming Bi, Avinash Kali, Ivan Cokic, Richard Tang, Roya Yumul, Antonio Conte, Sotirios Tsaftaris, Mourad Tighiouart, Debiao Li, Piotr J Slomka, Daniel Berman, Frank Prato, Joseph Fisher, Rohan Dharmakumar
Myocardial blood flow (MBF) is the critical determinant of cardiac function. However, its response to increases in partial pressure of arterial CO2 (PaCO2), particularly with respect to adenosine, is not well characterized due to challenges in blood gas control and limited availability of validated approaches to ascertain MBF in vivo. By prospectively and independently controlling PaCO2 and combining it with (13)N-ammonia Positron Emission Tomography (PET) measurements, we investigated whether a physiologically tolerable hypercapnic stimulus (~25-mmHg increase in PaCO2) can increase MBF to that observed with adenosine in three groups of canines: (i) without coronary stenosis; (ii) subjected to non-flow limiting coronary stenosis; and (iii) following pre-administration of caffeine...
March 2, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28251575/mlaa-based-attenuation-correction-of-flexible-hardware-components-in-hybrid-pet-mr-imaging
#18
Thorsten Heußer, Christopher M Rank, Yannick Berker, Martin T Freitag, Marc Kachelrieß
BACKGROUND: Accurate PET quantification demands attenuation correction (AC) for both patient and hardware attenuation of the 511 keV annihilation photons. In hybrid PET/MR imaging, AC for stationary hardware components such as patient table and MR head coil is straightforward, employing CT-derived attenuation templates. AC for flexible hardware components such as MR-safe headphones and MR radiofrequency (RF) surface coils is more challenging. Registration-based approaches, aligning CT-based attenuation templates with the current patient position, have been proposed but are not used in clinical routine...
December 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/28246950/biomarkers-from-in-vivo-molecular-imaging-of-breast-cancer-pretreatment-18-f-fdg-pet-predicts-patient-prognosis-and-pretreatment-dwi-mr-predicts-response-to-neoadjuvant-chemotherapy
#19
Francesca Gallivanone, Marta Maria Panzeri, Carla Canevari, Claudio Losio, Luigi Gianolli, Francesco De Cobelli, Isabella Castiglioni
OBJECTIVE: Human cancers display intra-tumor phenotypic heterogeneity and recent research has focused on developing image processing methods extracting imaging descriptors to characterize this heterogeneity. This work assesses the role of pretreatment (18)F-FDG PET and DWI-MR with respect to the prognosis and prediction of neoadjuvant chemotherapy (NAC) outcomes when image features are used to characterize primitive lesions from breast cancer (BC). MATERIALS AND METHODS: A retrospective protocol included 38 adult women with biopsy-proven BC...
February 28, 2017: Magma
https://www.readbyqxmd.com/read/28240672/transient-osteoporosis-of-the-hip-on-fdg-pet-ct
#20
Gary A Ulaner, Peter Sawan
Transient osteoporosis of the hip (TOH) is characterized by bone pain, osteopenia, and bone marrow edema in the absence of trauma. We present a 59-year-old man with chronic lymphocytic leukemia who underwent F-FDG PET/CT. F-FDG PET/CT demonstrated mildly FDG-avid lymph nodes consistent for chronic lymphocytic leukemia, as well as FDG-avidity in the right femoral head with corresponding osteopenia, rather than a focal lytic lesion. MR demonstrated bone marrow edema consistent with TOH. TOH is benign and self-limiting...
February 24, 2017: Clinical Nuclear Medicine
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