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https://www.readbyqxmd.com/read/27765636/cigarette-smoke-mediates-nuclear-to-cytoplasmic-trafficking-of-transcriptional-inhibitor-kaiso-through-muc1-and-p120-catenin
#1
Lili Zhang, Marianne Gallup, Lorna Zlock, Yu Ting Feeling Chen, Walter E Finkbeiner, Nancy A McNamara
Lung cancer is the leading cause of cancer-related death, and 87% of these deaths are directly attributable to smoking. Using three-dimensional cultures of primary human bronchial epithelial cells, we demonstrated that loss of adherens junction protein, epithelial cadherin, and the aberrant interaction of its adherens junction binding partner, p120-catenin (p120ctn), with the cytoplasmic tail of apical mucin-1 (MUC1-CT) represent initiating steps in the epithelial-to-mesenchymal transition. Smoke provoked the rapid nuclear entry of p120ctn in complex with MUC1-CT that was inhibited using the MUC1-CT inhibitory peptides, PMIP and GO-201...
October 17, 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/27739458/senescence-mediated-by-p16-ink4a-impedes-reprogramming-of-human-corneal-endothelial-cells-into-neural-crest-progenitors
#2
Wen-Juan Lu, Scheffer C G Tseng, Shuangling Chen, Sean Tighe, Yuan Zhang, Xin Liu, Szu-Yu Chen, Chen-Wei Su, Ying-Ting Zhu
Human corneal endothelial cells (HCECs) have limited proliferative capacity due to "contact-inhibition" at G1 phase. Such contact-inhibition can be delayed from Day 21 to Day 42 by switching EGF-containing SHEM to LIF/bFGF-containing MESCM through transient activation of LIF-JAK1-STAT3 signaling that delays eventual nuclear translocation of p16(INK4a). Using the latter system, we have reported a novel tissue engineering technique by implementing 5 weekly knockdowns with p120 catenin (p120) and Kaiso siRNAs since Day 7 to achieve effective expansion of HCEC monolayers to a transplantable size with a normal HCEC density, through reprogramming of HCECs into neural crest progenitors by activating p120-Kaiso-RhoA-ROCK-canonical BMP signaling...
October 14, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27694442/cell-specific-kaiso-zbtb33-regulation-of-cell-cycle-through-cyclin-d1-and-cyclin-e1
#3
Amir Pozner, Tommy W Terooatea, Bethany A Buck-Koehntop
The correlation between aberrant DNA methylation with cancer promotion and progression has prompted an interest in discerning the associated regulatory mechanisms. Kaiso (ZBTB33) is a specialized transcription factor that selectively recognizes methylated CpG-containing sites as well as a sequence-specific DNA target. Increasing reports link ZBTB33 overexpression and transcriptional activities with metastatic potential and poor prognosis in cancer, although there is little mechanistic insight into how cells harness ZBTB33 transcriptional capabilities to promote and progress disease...
November 18, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27574848/rhoh-participates-in-a-multi-protein-complex-with-the-zinc-finger-protein-kaiso-that-regulates-both-cytoskeletal-structures-and-chemokine-induced-t-cells
#4
Akihisa Mino, Anja Troeger, Christian Brendel, Alan Cantor, Chad Harris, Marioara F Ciuculescu, David A Williams
RhoH is a haematopoietic -specific, GTPase-deficient Rho GTPase that plays an essential role in T lymphocyte development and haematopoietic cell migration. RhoH is known to interact with ZAP70 in T cell receptor (TCR) signaling and antagonize Rac GTPase activity. To further elucidate the molecular mechanisms of RhoH in T cell function, we carried out in vivo biotinylation and mass spectrometry analysis to identify new RhoH-interacting proteins in Jurkat T cells. We indentified Kaiso by streptavidin capture and confirmed the interaction with RhoH by co-immunoprecipitation...
August 30, 2016: Small GTPases
https://www.readbyqxmd.com/read/27476607/characterization-of-novel-intragenotype-recombination-events-among-norovirus-pandemic-gii-4-variants
#5
Jones Anderson Monteiro Siqueira, Renato da Silva Bandeira, Maria Cleonice Aguiar Justino, Alexandre da Costa Linhares, Yvone Benchimol Gabbay
Recently, there has been an increase in the number of children hospitalized due to norovirus infection in Brazil. This is due both to the occurrence of more severe norovirus-related gastroenteritis cases after the introduction of the rotavirus vaccine and an increase in the tools for the detection of the disease. This pathogen is transmitted by the fecal-oral route, and the illness is characterized by diarrhea, vomiting, nausea and abdominal cramps. The genome of the virus is organized into three open reading frames showing strong mutation rates...
October 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27424525/african-americans-with-pancreatic-ductal-adenocarcinoma-exhibit-gender-differences-in-kaiso-expression
#6
Jacqueline Jones, Angana Mukherjee, Balasubramanyam Karanam, Melissa Davis, Jesse Jaynes, R Renee Reams, Windy Dean-Colomb, Clayton Yates
Kaiso, a bi-modal transcription factor, regulates gene expression, and is elevated in breast, prostate, and colon cancers. Depletion of Kaiso in other cancer types leads to a reduction in markers for the epithelial-mesenchymal transition (EMT) (Jones et al., 2014), however its clinical implications in pancreatic ductal adenocarcinoma (PDCA) have not been widely explored. PDCA is rarely detected at an early stage but is characterized by rapid progression and invasiveness. We now report the significance of the subcellular localization of Kaiso in PDCAs from African Americans...
October 1, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27152123/kaiso-mediates-human-icr1-methylation-maintenance-and-h19-transcriptional-fine-regulation
#7
Florian Bohne, David Langer, Ursula Martiné, Claudia S Eider, Regina Cencic, Matthias Begemann, Miriam Elbracht, Luzie Bülow, Thomas Eggermann, Ulrich Zechner, Jerry Pelletier, Bernhard Ulrich Zabel, Thorsten Enklaar, Dirk Prawitt
BACKGROUND: Genomic imprinting evolved in a common ancestor to marsupials and eutherian mammals and ensured the transcription of developmentally important genes from defined parental alleles. The regulation of imprinted genes is often mediated by differentially methylated imprinting control regions (ICRs) that are bound by different proteins in an allele-specific manner, thus forming unique chromatin loops regulating enhancer-promoter interactions. Factors that maintain the allele-specific methylation therefore are essential for the proper transcriptional regulation of imprinted genes...
2016: Clinical Epigenetics
https://www.readbyqxmd.com/read/26999717/kaiso-depletion-attenuates-transforming-growth-factor-%C3%AE-signaling-and-metastatic-activity-of-triple-negative-breast-cancer-cells
#8
B I Bassey-Archibong, J M Kwiecien, S B Milosavljevic, R M Hallett, L G A Rayner, M J Erb, C J Crawford-Brown, K B Stephenson, P-A Bédard, J A Hassell, J M Daniel
Triple-negative breast cancers (TNBCs) represent a subset of breast tumors that are highly aggressive and metastatic, and are responsible for a disproportionate number of breast cancer-related deaths. Several studies have postulated a role for the epithelial-to-mesenchymal transition (EMT) program in the increased aggressiveness and metastatic propensity of TNBCs. Although EMT is essential for early vertebrate development and wound healing, it is frequently co-opted by cancer cells during tumorigenesis. One prominent signaling pathway involved in EMT is the transforming growth factor-β (TGFβ) pathway...
2016: Oncogenesis
https://www.readbyqxmd.com/read/26955760/dual-regulatory-switch-through-interactions-of-tcf7l2-tcf4-with-stage-specific-partners-propels-oligodendroglial-maturation
#9
Chuntao Zhao, Yaqi Deng, Lei Liu, Kun Yu, Liguo Zhang, Haibo Wang, Xuelian He, Jincheng Wang, Changqing Lu, Laiman N Wu, Qinjie Weng, Meng Mao, Jianrong Li, Johan H van Es, Mei Xin, Lee Parry, Steven A Goldman, Hans Clevers, Q Richard Lu
Constitutive activation of Wnt/β-catenin inhibits oligodendrocyte myelination. Tcf7l2/Tcf4, a β-catenin transcriptional partner, is required for oligodendrocyte differentiation. How Tcf7l2 modifies β-catenin signalling and controls myelination remains elusive. Here we define a stage-specific Tcf7l2-regulated transcriptional circuitry in initiating and sustaining oligodendrocyte differentiation. Multistage genome occupancy analyses reveal that Tcf7l2 serially cooperates with distinct co-regulators to control oligodendrocyte lineage progression...
2016: Nature Communications
https://www.readbyqxmd.com/read/26905970/wnt-controls-the-transcriptional-activity-of-kaiso-through-ck1%C3%AE%C2%B5-dependent-phosphorylation-of-p120-catenin
#10
Beatriz del Valle-Pérez, David Casagolda, Ero Lugilde, Gabriela Valls, Montserrat Codina, Natàlia Dave, Antonio García de Herreros, Mireia Duñach
No abstract text is available yet for this article.
February 15, 2016: Journal of Cell Science
https://www.readbyqxmd.com/read/26734997/kaiso-a-transcriptional-repressor-promotes-cell-migration-and-invasion-of-prostate-cancer-cells-through-regulation-of-mir-31-expression
#11
Honghe Wang, Wei Liu, ShaNekkia Black, Omari Turner, Juliet M Daniel, Windy Dean-Colomb, Qinghua P He, Melissa Davis, Clayton Yates
Kaiso, a member of the BTB/POZ zinc finger protein family, functions as a transcriptional repressor by binding to sequence-specific Kaiso binding sites or to methyl-CpG dinucleotides. Previously, we demonstrated that Kaiso overexpression and nuclear localization correlated with the progression of prostate cancer (PCa). Therefore, our objective was to explore the molecular mechanisms underlying Kaiso-mediated PCa progression. Comparative analysis of miRNA arrays revealed that 13 miRNAs were significantly altered (> 1...
February 2, 2016: Oncotarget
https://www.readbyqxmd.com/read/26621336/mtss1-is-a-critical-epigenetically-regulated-tumor-suppressor-in-cml
#12
M Schemionek, O Herrmann, M M Reher, N Chatain, C Schubert, I G Costa, S Hänzelmann, E G Gusmao, S Kintsler, T Braunschweig, A Hamilton, G V Helgason, M Copland, A Schwab, C Müller-Tidow, S Li, T L Holyoake, T H Brümmendorf, S Koschmieder
Chronic myeloid leukemia (CML) is driven by malignant stem cells that can persist despite therapy. We have identified Metastasis suppressor 1 (Mtss1/MIM) to be downregulated in hematopoietic stem and progenitor cells from leukemic transgenic SCLtTA/Bcr-Abl mice and in patients with CML at diagnosis, and Mtss1 was restored when patients achieved complete remission. Forced expression of Mtss1 decreased clonogenic capacity and motility of murine myeloid progenitor cells and reduced tumor growth. Viral transduction of Mtss1 into lineage-depleted SCLtTA/Bcr-Abl bone marrow cells decreased leukemic cell burden in recipients, and leukemogenesis was reduced upon injection of Mtss1-overexpressing murine myeloid 32D cells...
April 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/26509105/engineering-of-human-corneal-endothelial-grafts
#13
Ying-Ting Zhu, Sean Tighe, Shuang-Ling Chen, Thomas John, Winston Y Kao, Scheffer C G Tseng
Human corneal endothelial cells (HCEC) play a pivotal role in maintaining corneal transparency. Unlike in other species, HCEC are notorious for their limited proliferative capacity in vivo after diseases, injury, aging, and surgery. Persistent HCEC dysfunction leads to sight-threatening bullous keratopathy with either an insufficient cell density or retrocorneal membrane due to endothelial-mesenchymal transition (EMT). Presently, the only solution to restore vision in eyes inflicted with bullous keratopathy or retrocorneal membrane relies upon transplantation of a cadaver human donor cornea containing a healthy corneal endothelium...
September 2015: Current Ophthalmology Reports
https://www.readbyqxmd.com/read/26454239/knockout-zbtb33-gene-results-in-an-increased-locomotion-exploration-and-pre-pulse-inhibition-in-mice
#14
Alexander V Kulikov, Valeria S Korostina, Elizabeth A Kulikova, Dariya V Fursenko, Andrey E Akulov, Mikhail P Moshkin, Egor B Prokhortchouk
The Zbtb33 gene encodes the Kaiso protein-a bimodal transcriptional repressor. Here, the effects of Zbtb33 gene disruption on the brain and behaviour of the Kaiso-deficient (KO) and C57BL/6 (WT) male mice were investigated. Behaviour was studied using the open field, novel object, elevated plus maze and acoustic startle reflex tests. Brain morphology was investigated with magnetic resonance imaging. Biogenic amine levels and gene expression in the brain were measured with high-performance liquid chromatography and quantitative real-time RT-PCR, respectively...
January 15, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/26424557/kaiso-represses-the-expression-of-glucocorticoid-receptor-via-a-methylation-dependent-mechanism-and-attenuates-the-anti-apoptotic-activity-of-glucocorticoids-in-breast-cancer-cells
#15
Lin Zhou, Yan Zhong, Fang-Hui Yang, Zi-Bo Li, Jiang Zhou, Xie-Hong Liu, Min Li, Fang Hu
Kaiso is a Pox Virus and Zinc Finger (POZ-ZF) transcription factor with bi-modal DNA-binding specificity. Here, we demonstrated that Kaiso expression is inversely correlated with glucocorticoid receptor (GR) expression in breast carcinomas. Knockdown of Kaiso increased GR expression, while overexpression of Kaiso inhibited GR expression in breast cancer cells. Furthermore, Kaiso repressed GR proximal promoter-reporter activity in a dose-dependent manner. Remarkably, ChIP experiments demonstrated that endogenous Kaiso was associated with the GR promoter sequence in a methylation-dependent manner...
March 2016: BMB Reports
https://www.readbyqxmd.com/read/26183023/transcriptional-activation-of-apaf1-by-kaiso-zbtb33-and-p53-is-attenuated-by-rela-p65
#16
Dong-In Koh, Haemin An, Min-Young Kim, Bu-Nam Jeon, Seo-Hyun Choi, Sujin Susanne Hur, Man-Wook Hur
KAISO, a member of the POK protein family, is induced by DNA-damaging agents to enhance apoptosis in a p53-dependent manner. Previously, we found that p53 interacts with KAISO, and acetylation of p53 lysine residues by p300 is modulated by KAISO. APAF1, the core molecule of the apoptosome, is transcriptionally activated by KAISO only in cells expressing p53, which binds to APAF1 promoter p53-response elements (p53REs). APAF1 transcriptional upregulation is further enhanced by KAISO augmentation of p53 binding to the APAF1 promoter distal p53RE#1 (bp, -765 to -739)...
September 2015: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/26073433/kaiso-overexpression-promotes-intestinal-inflammation-and-potentiates-intestinal-tumorigenesis-in-apc-min-mice
#17
Christina C Pierre, Joseph Longo, Meaghan Mavor, Snezana B Milosavljevic, Roopali Chaudhary, Ebony Gilbreath, Clayton Yates, Juliet M Daniel
Constitutive Wnt/β-catenin signaling is a key contributor to colorectal cancer (CRC). Although inactivation of the tumor suppressor adenomatous polyposis coli (APC) is recognized as an early event in CRC development, it is the accumulation of multiple subsequent oncogenic insults facilitates malignant transformation. One potential contributor to colorectal carcinogenesis is the POZ-ZF transcription factor Kaiso, whose depletion extends lifespan and delays polyp onset in the widely used Apc(Min/+) mouse model of intestinal cancer...
September 2015: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/26065264/-s100a3-is-a-new-target-gene-of-kaiso-in-mouse-skin
#18
N A Zhigalova, A S Sokolov, E B Prokhortchouk, S V Zhenilo
No abstract text is available yet for this article.
March 2015: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/25937776/kaiso-mainly-locates-in-the-nucleus-in-vivo-and-binds-to-methylated-but-not-hydroxymethylated-dna
#19
Sisi Qin, Baozhen Zhang, Wei Tian, Liankun Gu, Zheming Lu, Dajun Deng
OBJECTIVE: Kaiso is upregulated in many cancers and proposed to bind with both methylated- and unmethylated-DNA in the nucleus as a transcriptional repressor. The objective is to define its subcellular localization in vivo and exact binding DNA sequences in cells. METHODS: Compartmentalization of exogenous Kaiso in cells was tracked with enhanced green fluorescence protein (EGFP) tag. The endogenous Kaiso expression in gastric carcinoma tissue was examined with immunohistochemical staining...
April 2015: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/25713299/nuclear-p120-catenin-regulates-the-anoikis-resistance-of-mouse-lobular-breast-cancer-cells-through-kaiso-dependent-wnt11-expression
#20
Robert A H van de Ven, Milou Tenhagen, Wouter Meuleman, Jeske J G van Riel, Ron C J Schackmann, Patrick W B Derksen
E-cadherin inactivation underpins the progression of invasive lobular breast carcinoma (ILC). In ILC, p120-catenin (p120) translocates to the cytosol where it controls anchorage independence through the Rho-Rock signaling pathway, a key mechanism driving tumor growth and metastasis. We now demonstrate that anchorage-independent ILC cells show an increase in nuclear p120, which results in relief of transcriptional repression by Kaiso. To identify the Kaiso target genes that control anchorage independence we performed genome-wide mRNA profiling on anoikis-resistant mouse ILC cells, and identified 29 candidate target genes, including the established Kaiso target Wnt11...
April 2015: Disease Models & Mechanisms
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