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https://www.readbyqxmd.com/read/28544159/simultaneous-measurement-of-t1-b1-and-pharmacokinetic-model-parameters-using-active-contrast-encoding-ace-mri
#1
Jin Zhang, Kerryanne Winters, Olivier Reynaud, Sungheon Gene Kim
The aim of this study was to assess the feasibility of combining dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) with the measurement of the radiofrequency (RF) transmit field B1 and pre-contrast longitudinal relaxation time T10 . A novel approach has been proposed to simultaneously estimate B1 and T10 from a modified DCE-MRI scan that actively encodes the washout phase of the curve with different amounts of T1 and B1 weighting using multiple flip angles and repetition times, hence referred to as active contrast encoding (ACE)-MRI...
May 22, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28543885/dce-mri-prediction-of-survival-time-for-patients-with-glioblastoma-multiforme-using-an-adaptive-neuro-fuzzy-based-model-and-nested-model-selection-technique
#2
Azimeh N V Dehkordi, Alireza Kamali-Asl, Ning Wen, Tom Mikkelsen, Indrin J Chetty, Hassan Bagher-Ebadian
This pilot study investigates the construction of an Adaptive Neuro-Fuzzy Inference System (ANFIS) for the prediction of the survival time of patients with glioblastoma multiforme (GBM). ANFIS is trained by the pharmacokinetic (PK) parameters estimated by the model selection (MS) technique in dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) data analysis, and patient age. DCE-MRI investigations of 33 treatment-naïve patients with GBM were studied. Using the modified Tofts model and MS technique, the following physiologically nested models were constructed: Model 1, no vascular leakage (normal tissue); Model 2, leakage without efflux; Model 3, leakage with bidirectional exchange (influx and efflux)...
May 25, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28536804/modeling-dynamic-contrast-enhanced-mri-data-with-a-constrained-local-aif
#3
Chong Duan, Jesper F Kallehauge, Carlos J Pérez-Torres, G Larry Bretthorst, Scott C Beeman, Kari Tanderup, Joseph J H Ackerman, Joel R Garbow
PURPOSE: This study aims to develop a constrained local arterial input function (cL-AIF) to improve quantitative analysis of dynamic contrast-enhanced (DCE)-magnetic resonance imaging (MRI) data by accounting for the contrast-agent bolus amplitude error in the voxel-specific AIF. PROCEDURES: Bayesian probability theory-based parameter estimation and model selection were used to compare tracer kinetic modeling employing either the measured remote-AIF (R-AIF, i.e...
May 23, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28536087/workflow-sensitivity-of-post-processing-methods-in-renal-dce-mri
#4
Erik Hanson, Eli Eikefjord, Jarle Rørvik, Erling Andersen, Arvid Lundervold, Erlend Hodneland
OBJECTIVE: Estimation of renal filtration using dynamic contrast-enhanced imaging (DCE-MRI) requires a series of analysis steps. The possible number of distinct post-processing chains is large and grows rapidly with increasing number of processing steps or options. In this study we introduce a framework for systematic evaluation of the post-processing chains. The framework is later used to highlight the workflow processing chain sensitivity towards accuracy in estimation of glomerular filtration rate (GFR)...
May 20, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28534322/-value-of-functional-magnetic-resonance-imaging-in-predicting-outcomes-of-neoadjuvant-chemoradiotherapy-in-rectal-cancer
#5
Yishan Yu, Jinbo Yue, Jinming Yu
Rectal cancer is one of the common cancers which poses a threat to the health of mankind. In recent years. Multi-modality treatment strategies for locally advanced rectal cancer improve the treatment efficiency. Accurate prediction of the treatment response after the neoadjuvant chemoradiotherapy (CRT) can guide more suitable treatment strategy. MERCURY study proved the prognostic value of post-CRT standard morphologic MRI(T2-weighted) assessment of tumor regression grade(TRG), and MRI assessment of circumferential resection margin can guide the definitive surgery...
May 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28525448/18f-fluorocholine-pet-ct-complementing-the-role-of-dynamic-contrast-enhanced-mri-for-providing-comprehensive-diagnostic-workup-in-prostate-cancer-patients-with-suspected-relapse-following-radical-prostatectomy
#6
Shelvin Kumar Vadi, Baljinder Singh, Rajender K Basher, Ankit Watts, Ashwani K Sood, Anupam Lal, Nandita Kakkar, S K Singh
PURPOSE: The aim of this study was to compare the diagnostic performance of F-fluorocholine (FCH) PET/CT and dynamic contrast-enhanced MRI (DCE-MRI) of pelvis in restaging prostate cancer (PC) patients with biochemical recurrence (BCR) following radical prostatectomy (RP). METHODS: Twenty PC patients who had undergone RP and had BCR were recruited in this study. All the patients underwent whole-body FCH PET/CT and DCE-MRI of the pelvis. An overall pattern of recurrent disease was analyzed, and diagnostic accuracy for the detection of pelvic disease recurrence by the 2 modalities was evaluated by taking histopathologic analysis as the criterion standard...
May 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28524459/prognostic-role-of-conventional-and-dynamic-contrast-enhanced-mri-in-optic-pathway-gliomas
#7
Nutchawan Jittapiromsak, Ping Hou, Ho-Ling Liu, Jia Sun, John M Slopis, T Linda Chi
BACKGROUND AND PURPOSE: The natural history of optic pathway glioma (OPG) is highly variable and unpredictable. We present a pilot study of the prognostic role of conventional and dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) in the evaluation of OPG. METHODS: We retrospectively reviewed 17 patients with 20 pretreatment OPG lesions who underwent conventional and DCE MRI between January 2010 and December 2016. Conventional MRI was evaluated for enhancement pattern, cystic component, optic nerve tortuosity, optic nerve dural ectasia, and optic nerve perineural thickening...
May 19, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/28522877/dce-mri-background-parenchymal-enhancement-quantified-from-an-early-versus-delayed-post-contrast-sequence-association-with-breast-cancer-presence
#8
Shandong Wu, Margarita L Zuley, Wendie A Berg, Brenda F Kurland, Rachel C Jankowitz, Jules H Sumkin, David Gur
We investigated automated quantitative measures of background parenchymal enhancement (BPE) derived from an early versus delayed post-contrast sequence in breast dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for association with breast cancer presence in a case-control study. DCE-MRIs were retrospectively analyzed for 51 cancer cases and 51 controls with biopsy-proven benign lesions, matched by age and year-of-MRI. BPE was quantified using fully-automated validated computer algorithms, separately from three sequential DCE-MRI post-contrast-subtracted sequences (SUB1, SUB2, and SUB3)...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28521821/intratumoral-and-peritumoral-radiomics-for-the-pretreatment-prediction-of-pathological-complete-response-to-neoadjuvant-chemotherapy-based-on-breast-dce-mri
#9
Nathaniel M Braman, Maryam Etesami, Prateek Prasanna, Christina Dubchuk, Hannah Gilmore, Pallavi Tiwari, Donna Pletcha, Anant Madabhushi
BACKGROUND: In this study, we evaluated the ability of radiomic textural analysis of intratumoral and peritumoral regions on pretreatment breast cancer dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to predict pathological complete response (pCR) to neoadjuvant chemotherapy (NAC). METHODS: A total of 117 patients who had received NAC were retrospectively analyzed. Within the intratumoral and peritumoral regions of T1-weighted contrast-enhanced MRI scans, a total of 99 radiomic textural features were computed at multiple phases...
May 18, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28515410/differentiating-between-central-nervous-system-lymphoma-and-high-grade-glioma-using-dynamic-susceptibility-contrast-and-dynamic-contrast-enhanced-mr-imaging-with-histogram-analysis
#10
Kazuhiro Murayama, Yuya Nishiyama, Yuichi Hirose, Masato Abe, Shigeharu Ohyu, Ayako Ninomiya, Takashi Fukuba, Kazuhiro Katada, Hiroshi Toyama
PURPOSE: We evaluated the diagnostic performance of histogram analysis of data from a combination of dynamic susceptibility contrast (DSC)-magnetic resonance imaging (MRI) and dynamic contrast-enhanced (DCE)-MRI for quantitative differentiation between central nervous system lymphoma (CNSL) and high-grade glioma (HGG), with the aim of identifying useful perfusion parameters as objective radiological markers for differentiating between them. METHODS: Eight lesions with CNSLs and 15 with HGGs who underwent MRI examination, including DCE and DSC-MRI, were enrolled in our retrospective study...
May 18, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/28501096/combined-diffusion-weighted-imaging-and-dynamic-contrast-enhanced-mri-for-differentiating-radiologically-indeterminate-malignant-from-benign-orbital-masses
#11
X-Q Xu, W Qian, G Ma, H Hu, G-Y Su, H Liu, H-B Shi, F-Y Wu
AIM: To evaluate the performance of the combination of diffusion-weighted (DW) and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) for differentiating radiologically indeterminate malignant from benign orbital masses. MATERIALS AND METHODS: Sixty-five patients with orbital masses (36 benign and 29 malignant) underwent DW and DCE MRI examinations for pre-treatment evaluation. The apparent diffusion coefficient (ADC) was derived from DW imaging data using the mono-exponential model...
May 10, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28493613/subtle-blood-brain-barrier-leakage-rate-and-spatial-extent-considerations-for-dynamic-contrast-enhanced-mri
#12
Harm J van de Haar, Jacobus F A Jansen, Cécile R L P N Jeukens, Saartje Burgmans, Mark A van Buchem, Majon Muller, Paul A M Hofman, Frans R J Verhey, Matthias J P van Osch, Walter H Backes
PURPOSE: Dynamic contrast-enhanced (DCE) MRI can be used to measure blood-brain barrier (BBB) leakage. In neurodegenerative disorders such as small vessel disease and dementia, the leakage can be very subtle and the corresponding signal can be rather noisy. For these reasons, an optimized DCE-MRI measurement and study design is required. To this end, a new measure indicative of the spatial extent of leakage is introduced and the effects of scan time and sample size are explored. METHODS: Dual-time resolution DCE-MRI was performed in 16 patients with early Alzheimer's disease (AD) and 17 healthy controls...
May 11, 2017: Medical Physics
https://www.readbyqxmd.com/read/28490763/methylglyoxal-induced-glycation-changes-adipose-tissue-vascular-architecture-flow-and-expansion-leading-to-insulin-resistance
#13
Tiago Rodrigues, Paulo Matafome, José Sereno, José Almeida, João Castelhano, Luís Gamas, Christian Neves, Sónia Gonçalves, Catarina Carvalho, Amina Arslanagic, Elinor Wilcken, Rita Fonseca, Ilda Simões, Silvia Vilares Conde, Miguel Castelo-Branco, Raquel Seiça
Microvascular dysfunction has been suggested to trigger adipose tissue dysfunction in obesity. This study investigates the hypothesis that glycation impairs microvascular architecture and expandability with an impact on insulin signalling. Animal models supplemented with methylglyoxal (MG), maintained with a high-fat diet (HFD) or both (HFDMG) were studied for periepididymal adipose (pEAT) tissue hypoxia and local and systemic insulin resistance. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) was used to quantify blood flow in vivo, showing MG-induced reduction of pEAT blood flow...
May 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28487383/monitoring-tumor-response-to-anti-vascular-therapy-using-non-contrast-intravoxel-incoherent-motion-diffusion-weighted-mri
#14
Changzheng Shi, Dexiang Liu, Zeyu Xiao, Dong Zhang, Guanfu Liu, Guanshu Liu, Hanwei Chen, Liangping Luo
Anti-vascular therapy is a promising approach to the treatment of non-small-cell lung cancer (NSCLC), where an imaging modality capable of longitudinally monitoring treatment response could provide early prediction of the outcome. In this study, we sought to investigate the feasibility of using intravoxel incoherent motion (IVIM) diffusion MRI to quantitatively assess the efficacy of the treatments of a vascular disrupting agent CA4P or its combination with bevacizumab (BV) on experimental NSCLC tumors. CA4P caused a strong but reversible effect on tumor vasculature: all perfusion-related parameters-D*, f, fD*, and K(trans)-initially showed a decrease of 30%-60% at two hours and then fully recovered to baseline on day 2 for CA4P treatment or on days 4-8 for CA4P + BV treatment; the diffusion coefficient in tumors decreased initially at two hours and then increased from day 2 to day 8...
May 9, 2017: Cancer Research
https://www.readbyqxmd.com/read/28487019/dynamic-contrast-enhanced-mri-of-the-placenta-a-tool-for-prenatal-diagnosis-of-placenta-accreta
#15
A E Millischer, B Deloison, S Silvera, Y Ville, N Boddaert, D Balvay, N Siauve, C A Cuenod, V Ttsatsaris, L Sentilhes, L J Salomon
BACKGROUND: Ultrasound (US) is the primary imaging modality for the diagnosis of placenta accreta, but it is not sufficiently accurate. MRI morphologic criteria have recently emerged as a useful tool in this setting, but their analysis is too subjective. Recent studies suggest that gadolinium enhancement may help to distinguish between the stretched myometrium and placenta within a scar area. However, objective MRI criteria are still required for prenatal diagnosis of placenta accreta...
May 2017: Placenta
https://www.readbyqxmd.com/read/28480550/a-one-step-biomarker-quantification-methodology-for-dce-mri-of-adnexal-masses-capturing-kinetic-pattern-from-early-to-late-enhancement
#16
Anahita Fathi Kazerooni, Mahnaz Nabil, Hamidreza Haghighat Khah, Sara Parviz, Masoumeh Gity, Hamidreza Saligheh Rad
PURPOSE: To develop a one-step quantification approach that accounts for joint preprocessing and quantification of whole-range kinetics (early and late-phase washout) of dynamic contrast-enhanced (DCE) MRI of indeterminate adnexal masses. METHODS: Preoperative DCE-MRI of 43 (24 benign, 19 malignant) sonographically indeterminate adnexal masses were analyzed prospectively. A five-parameter sigmoid function was implemented to model the enhancement curves calculated within regions of interest...
May 7, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28455630/relationship-between-carotid-plaque-surface-morphology-and-perfusion-a-3d-dce-mri-study
#17
Jianmin Yuan, Gregory Makris, Andrew Patterson, Ammara Usman, Tilak Das, Andrew Priest, Zhongzhao Teng, Sarah Hilborne, Dario Prudencio, Jonathan Gillard, Martin Graves
OBJECTIVE: This study aims to explore the relationship between plaque surface morphology and neovascularization using a high temporal and spatial resolution 4D contrast-enhanced MRI/MRA sequence. MATERIALS AND METHODS: Twenty one patients with either recent symptoms or a carotid artery stenosis ≥40% were recruited in this study. Plaque surface morphology and luminal stenosis were determined from the arterial phase MRA images. Carotid neovascularization was evaluated by a previously validated pharmacokinetic (PK) modeling approach...
April 28, 2017: Magma
https://www.readbyqxmd.com/read/28449009/the-prognostic-value-of-dynamic-contrast-enhanced-mri-contrast-agent-transfer-constant-k-trans-in-cervical-cancer-is-explained-by-plasma-flow-rather-than-vessel-permeability
#18
Ben R Dickie, Chris J Rose, Lucy E Kershaw, Stephanie B Withey, Bernadette M Carrington, Susan E Davidson, Gillian Hutchison, Catharine M L West
BACKGROUND: The microvascular contrast agent transfer constant K(trans) has shown prognostic value in cervical cancer patients treated with chemoradiotherapy. This study aims to determine whether this is explained by the contribution to K(trans) of plasma flow (Fp), vessel permeability surface-area product (PS), or a combination of both. METHODS: Pre-treatment dynamic contrast-enhanced MRI (DCE-MRI) data from 36 patients were analysed using the two-compartment exchange model...
May 23, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28448404/dynamic-contrast-enhanced-magnetic-resonance-imaging-of-ocular-melanoma-as-a-tool-to-predict-metastatic-potential
#19
Wenbo Wei, Guang Jia, Hendrik von Tengg-Kobligk, Johannes T Heverhagen, Mohamed Abdel-Rahman, Lai Wei, John B Christoforidis, Frederick Davidorf, Michael V Knopp
PURPOSE: This study explores the capability of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to differentiate tumor characteristics of metastatic and nonmetastatic choroidal melanoma as a potential tool for patient management. MATERIALS AND METHODS: A total of 13 patients (69 ± 9 years) with choroidal melanoma were imaged using DCE-MRI on a 3-T MRI system with a 16-channel head coil. The Tofts 2-compartment model was chosen for quantification, and parameters K (the transfer constant from the blood plasma to the extracellular space) and Kep (the transfer constant from the extracellular space to the blood plasma) were calculated and compared...
April 26, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28447564/pretreatment-late-phase-dce-mri-predicts-outcome-in-locally-advanced-cervix-cancer
#20
Kjersti V Lund, Trude G Simonsen, Gunnar B Kristensen, Einar K Rofstad
BACKGROUND: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) may provide prognostic biomarkers for cervix carcinoma. We have shown previously that the early phase of the signal intensity-versus-time curve (SITC) may have significant prognostic power. The purpose of the present investigation was to explore the prognostic value of the late phase of the SITC. MATERIAL AND METHODS: DCE-MRI data of 80 patients (FIGO stage IB-IVA) treated with concurrent chemoradiotherapy were examined...
May 2017: Acta Oncologica
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