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https://www.readbyqxmd.com/read/28325514/multiparametric-approach-with-diffusion-weighted-imaging-and-dynamic-contrast-enhanced-mri-a-comparison-study-for-differentiating-between-benign-and-malignant-bone-lesions-in-adults
#1
E Oh, Y C Yoon, J H Kim, K Kim
AIM: To evaluate and compare the diagnostic performance of quantitative parameters derived from diffusion-weighted imaging (DWI) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in differentiating benign and malignant bone tumours. MATERIALS AND METHODS: Fifty-five patients (age range, 21-82 years; mean age, 55 years) underwent pretreatment MRI. Apparent diffusion coefficient (ADC) values were calculated by DWI. The DCE-MRI data were analysed for the volume transfer constant (K(trans)), extravascular extracellular volume fraction (Ve), and volume rate constant (Kep), and K(trans)/ADC ratio...
March 18, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28317128/comparison-of-dce-mri-kinetic-parameters-and-fmiso-pet-uptake-parameters-in-head-and-neck-cancer-patients
#2
Urban Simoncic, Sara Leibfarth, Stefan Welz, Nina Schwenzer, Holger Schmidt, Gerald Reischl, Christina Pfannenberg, Christian la Fougère, Konstantin Nikolaou, Daniel Zips, Daniela Thorwarth
PURPOSE: Tumour hypoxia is a major cause of radiation resistance, often present in various solid tumours. Dynamic [(18) F]-fluoromisonidazole (FMISO) PET imaging is able to reliably assess tumour hypoxia. Comprehensive characterization of tumour microenvironment through FMISO-PET and dynamic contrast enhanced (DCE) MR multimodality imaging might be a valuable alternative to the dynamic FMISO-PET acquisition. The aim of this work was to explore the correlation between the FMISO-PET and DCE-MRI kinetic parameters...
March 20, 2017: Medical Physics
https://www.readbyqxmd.com/read/28314789/non-invasive-imaging-of-cycling-hypoxia-in-head-neck-cancer-using-intrinsic-susceptibility-mri
#3
Rafal Panek, Liam Welsh, Lauren Cj Baker, Maria A Schmidt, Kee H Wong, Angela Riddell, Dow-Mu Koh, Alex Dunlop, Dualta Mcquaid, James A d'Arcy, Shreerang Bhide, Kevin J Harrington, Christopher M Nutting, Georgina Hopkinson, Cheryl Richardson, Carol Box, Suzanne A Eccles, Martin O Leach, Simon P Robinson, Katie L Newbold
PURPOSE: To evaluate intrinsic susceptibility (IS) MRI for the identification of cycling hypoxia, and the assessment of its extent and spatial distribution, in head and neck squamous cell carcinoma (HNSCC) xenografts and patients. EXPERIMENTAL DESIGN: Quantitation of the transverse relaxation rate R2*, which is sensitive to paramagnetic deoxyhemoglobin, using serial IS-MRI acquisitions, was used to monitor temporal oscillations in levels of paramagnetic deoxyhemoglobin in human CAL(R) xenografts and patients with HNSCC at 3T...
March 17, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28314275/relationship-between-ktrans-and-k1-with-simultaneous-versus-separate-mr-pet-in-rabbits-with-vx2-tumors
#4
Kyung Hee Lee, Seung Kwan Kang, Jin Mo Goo, Jae Sung Lee, Gi Jeong Cheon, Seongho Seo, Eui Jin Hwang
BACKGROUND/AIM: To compare the relationship between Ktrans from DCE-MRI and K1 from dynamic (13)N-NH3-PET, with simultaneous and separate MR/PET in the VX-2 rabbit carcinoma model. MATERIALS AND METHODS: MR/PET was performed simultaneously and separately, 14 and 15 days after VX-2 tumor implantation at the paravertebral muscle. The Ktrans and K1 values were estimated using an in-house software program. The relationships between Ktrans and K1 were analyzed using Pearson's correlation coefficients and linear/non-linear regression function...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28303695/dynamic-contrast-enhanced-mri-perfusion-for-differentiating-between-melanoma-and-lung-cancer-brain-metastases
#5
Vaios Hatzoglou, Jamie Tisnado, Alpesh Mehta, Kyung K Peck, Mariza Daras, Antonio M Omuro, Kathryn Beal, Andrei I Holodny
Brain metastases originating from different primary sites overlap in appearance and are difficult to differentiate with conventional MRI. Dynamic contrast-enhanced (DCE)-MRI can assess tumor microvasculature and has demonstrated utility in characterizing primary brain tumors. Our aim was to evaluate the performance of plasma volume (Vp) and volume transfer coefficient (K(trans) ) derived from DCE-MRI in distinguishing between melanoma and nonsmall cell lung cancer (NSCLC) brain metastases. Forty-seven NSCLC and 23 melanoma brain metastases were retrospectively assessed with DCE-MRI...
March 17, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28303489/in-vivo-dce-mri-for-the-discrimination-between-glioblastoma-and-radiation-necrosis-in-rats
#6
Julie Bolcaen, Benedicte Descamps, Marjan Acou, Karel Deblaere, Caroline Van den Broecke, Tom Boterberg, Christian Vanhove, Ingeborg Goethals
PURPOSE: In this study, the potential of semiquantitative and quantitative analysis of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) was investigated to differentiate glioblastoma (GB) from radiation necrosis (RN) in rats. PROCEDURES: F98 GB growth was seen on MRI 8-23 days post-inoculation (n = 15). RN lesions developed 6-8 months post-irradiation (n = 10). DCE-MRI was acquired using a fast low-angle shot (FLASH) sequence. Regions of interest (ROIs) encompassed peripheral contrast enhancement in GB (n = 15) and RN (n = 10) as well as central necrosis within these lesions (GB (n = 4), RN (n = 3))...
March 16, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28299943/the-value-of-combining-conventional-diffusion-weighted-and-dynamic-contrast-enhanced-mr-imaging-for-the-diagnosis-of-parotid-gland-tumors
#7
Xiaofeng Tao, Gongxin Yang, Pingzhong Wang, Yingwei Wu, Wenjing Zhu, Huimin Shi, Xin Gong, Weiqing Gao, Qiang Yu
OBJECTIVE: The aim of this study was to determine the value of combining conventional MRI, diffusion-weighted (DWI) and dynamic contrast enhanced MRI (DCE-MRI) in diagnosing solid neoplasms in the parotid gland. METHODS: A total of 148 subjects (101 with benign and 47 with malignant tumors) were evaluated with conventional MRI, DWI and DCE-MRI prior to surgery and pathologic verification. The items observed with conventional MRI included the shape, capsule and signal intensity of parotid masses...
March 16, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28297442/correlation-of-quantitative-dynamic-contrast-enhanced-mri-with-microvascular-density-in-necrotic-partial-necrotic-and-viable-liver-tumors-in-a-rabbit-model
#8
Jungwon Moon, Jae-Hun Kim, Dongil Choi, Jehoon Yang, Min Woo Lee, Yoon-La Choi, Hyunchul Rhim Md
The purpose of this study was to examine the correlation of quantitative dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) with microvessel density (MVD) in necrotic, partial necrotic, and viable tumors using a rabbit VX2 liver tumor model. Nine rabbits were used for this study. The complete necrotic area (CNA), partial necrotic area (PNA), and viable tumor area (VTA) of liver tumors were experimentally induced by radiofrequency ablation (RFA). DCE-MRI data were processed based on the extended Kety model to estimate Ktrans,ve and vp parameters...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297421/characteristics-of-quantitative-perfusion-parameters-on-dynamic-contrast-enhanced-mri-in-mammographically-occult-breast-cancer
#9
Jung Kyu Ryu, Sun Jung Rhee, Jeong Yoon Song, Soo Hyun Cho, Geon-Ho Jahng
The purpose of this study was to compare the characteristics of quantitative perfusion parameters obtained from dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) in patients with mammographically occult (MO) breast cancers and those with mammographically visible (MV) breast cancers. Quantitative parameters (AUC, Ktrans,kep,ve,vp, and wi) from 13 MO breast cancers and 16 MV breast cancers were mapped after the DCE-MRI data were acquired. Various prognostic factors, including axillary nodal status, estrogen receptor (ER), progesterone receptor (PR), Ki-67, p53, E-cadherin, and human epidermal growth factor receptor 2 (HER2) were obtained in each group...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28295791/value-of-breast-mri-for-patients-with-a-biopsy-showing-atypical-ductal-hyperplasia-adh
#10
Keiko Tsuchiya, Naoko Mori, David V Schacht, Deepa Sheth, Gregory S Karczmar, Gillian M Newstead, Hiroyuki Abe
PURPOSE: To evaluate the diagnostic value of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) for patients with atypical ductal hyperplasia (ADH) in predicting malignant upgrade. MATERIALS AND METHODS: 3T DCE-MRI was performed for 17 patients with ADH (median age 52, range 42-76) proven by stereotactic biopsy (n = 15), and ultrasound-guided biopsy (n = 2) from January 2011 to April 2015. All patients underwent surgical excision after the MRI...
March 10, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28282379/tensor-based-multichannel-reconstruction-for-breast-tumours-identification-from-dce-mris
#11
X-X Yin, S Hadjiloucas, J-H Chen, Y Zhang, J-L Wu, M-Y Su
A new methodology based on tensor algebra that uses a higher order singular value decomposition to perform three-dimensional voxel reconstruction from a series of temporal images obtained using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is proposed. Principal component analysis (PCA) is used to robustly extract the spatial and temporal image features and simultaneously de-noise the datasets. Tumour segmentation on enhanced scaled (ES) images performed using a fuzzy C-means (FCM) cluster algorithm is compared with that achieved using the proposed tensorial framework...
2017: PloS One
https://www.readbyqxmd.com/read/28269607/a-dce-mri-imaging-based-model-for-simulation-of-vascular-tumour-growth
#12
Thais Roque, Veerle Kersemans, Sean Smart, Danny Allen, Julia A Schnabel, Michael Chappell
Imaging-based modelling of tumour growth can serve as a powerful tool to understand and predict tumour evolution and its response to therapy. The purpose of this study was to introduce, calibrate and evaluate a multi-scale model of vascular tumour growth. The model allows for proliferation, death and spatial spread of tumour cells as well as for new vessel creation. Both the calibration and the evaluation of the tumour growth model were performed using pre-clinical longitudinal time series of dynamic contrast-enhanced magnetic resonance imaging of colon carcinoma...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28265853/response-derived-input-function-estimation-for-dynamic-contrast-enhanced-mri-demonstrated-by-anti-dll4-treatment-in-a-murine-u87-xenograft-model
#13
Matthew D Silva, Brittany Yerby, Jodi Moriguchi, Albert Gomez, H Toni Jun, Angela Coxon, Sharon E Ungersma
PURPOSE: Dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) is an accepted method to evaluate tumor perfusion and permeability and anti-vascular cancer therapies. However, there is no consensus on the vascular input function estimation method, which is critical to kinetic modeling and K (trans) estimation. This work proposes a response-derived input function (RDIF) estimated from the response of the tumor, modeled as a linear, time-invariant (LTI) system. PROCEDURES: In an LTI system, an unknown input can be estimated from the system response...
March 6, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28263425/fast-bilateral-breast-coverage-with-high-spectral-and-spatial-resolution-hiss-mri-at-3t
#14
Milica Medved, Hui Li, Hiroyuki Abe, Deepa Sheth, Gillian M Newstead, Olufunmilayo I Olopade, Maryellen L Giger, Gregory S Karczmar
PURPOSE: To develop and assess a full-coverage, sensitivity encoding (SENSE)-accelerated breast high spatial and spectral resolution (HiSS) magnetic resonance imaging (MRI) within clinically reasonable times as a potential nonenhanced MRI protocol for breast density measurement or breast cancer screening. MATERIALS AND METHODS: Sixteen women with biopsy-proven cancer or suspicious lesions, and 13 women who were healthy volunteers or were screened for breast cancer, received 3T breast MRI exams, including SENSE-accelerated HiSS MRI, which was implemented as a submillimeter spatial resolution echo-planar spectroscopic imaging (EPSI) sequence...
March 6, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28260285/-value-of-dce-mri-and-dwi-in-the-differential-diagnosis-of-inflammatory-pseudotumor-and-lymphoma-in-the-lacrimal-gland
#15
L L Feng, J F Xian, F Yan, L Fu, H Y Zhou
Objective: To evaluate the value of dynamic contrast-enhanced MR (DCE-MRI) and diffusion weighted MR (DWI) in differential diagnosis of inflammatory pseudotumor and lymphoma in the lacrimal gland. Methods: In this retrospective study, a total of 24 cases of inflammatory pseudotumor and 22 cases of lymphoma in the lacrimal gland at Beijing Tongren Hospital confirmed by histological results were enrolled from January 2010 to January 2015.DCE-MRI and DWI were performed in these cases, and the type of time-signal intensity curve (time-intensity curve, TIC), the peak contrast index (CIpeak), maximum enhancement ratio (ERmax), washout ratio (WR) and ADC value were analyzed...
February 21, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28256615/associations-between-tumor-vascularity-vascular-endothelial-growth-factor-expression-and-pet-mri-radiomic-signatures-in-primary-clear-cell-renal-cell-carcinoma-proof-of-concept-study
#16
Qingbo Yin, Sheng-Che Hung, Li Wang, Weili Lin, Julia R Fielding, W Kimryn Rathmell, Amir H Khandani, Michael E Woods, Matthew I Milowsky, Samira A Brooks, Eric M Wallen, Dinggang Shen
Studies have shown that tumor angiogenesis is an essential process for tumor growth, proliferation and metastasis. Also, tumor angiogenesis is an important prognostic factor of clear cell renal cell carcinoma (ccRCC), as well as a factor in guiding treatment with antiangiogenic agents. Here, we attempted to find the associations between tumor angiogenesis and radiomic imaging features from PET/MRI. Specifically, sparse canonical correlation analysis was conducted on 3 feature datasets (i.e., radiomic imaging features, tumor microvascular density (MVD), and vascular endothelial growth factor (VEGF) expression) from 9 patients with primary ccRCC...
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28253722/evaluation-of-the-efficacy-of-neoadjuvant-chemotherapy-for-breast-cancer-using-diffusion-weighted-imaging-and-dynamic-contrast-enhanced-magnetic-resonance-imaging
#17
H D Xu, Y Q Zhang
This study aims to investigate the predictive values of diffusion-weighted imaging (DWI) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in evaluating the efficacy of neoadjuvant chemotherapy (NAC) for breast cancer. Between September 2011 and December 2014, a total of 174 patients with locally advanced breast cancer treated with NAC were selected for this study. Conventional CT and MRI examinations (DWI and DCE-MRI) were performed in all patients before NAC (T0), after the first course (T1) and after the whole course (T2) of NAC...
March 3, 2017: Neoplasma
https://www.readbyqxmd.com/read/28246509/the-effects-of-breathing-motion-on-dce-mri-images-phantom-studies-simulating-respiratory-motion-to-compare-caipirinha-vibe-radial-vibe-and-conventional-vibe
#18
Chang Kyung Lee, Nieun Seo, Bohyun Kim, Jimi Huh, Jeong Kon Kim, Seung Soo Lee, In Seong Kim, Dominik Nickel, Kyung Won Kim
OBJECTIVE: To compare the breathing effects on dynamic contrast-enhanced (DCE)-MRI between controlled aliasing in parallel imaging results in higher acceleration (CAIPIRINHA)-volumetric interpolated breath-hold examination (VIBE), radial VIBE with k-space-weighted image contrast view-sharing (radial-VIBE), and conventional VIBE (c-VIBE) sequences using a dedicated phantom experiment. MATERIALS AND METHODS: We developed a moving platform to simulate breathing motion...
March 2017: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/28245479/potential-utility-of-diffusion-weighted-magnetic-resonance-imaging-in-diagnosis-of-residual-bladder-cancer-before-second-transurethral-resection
#19
Yuki Nakamura, Soichiro Yoshida, Hiroshi Tanaka, Masaharu Inoue, Masaya Ito, Toshiki Kijima, Minato Yokoyama, Junichiro Ishioka, Yoh Matsuoka, Kazutaka Saito, Yasuhisa Fujii, Kazunori Kihara
INTRODUCTION: The study aimed to investigate the diagnostic utility of diffusion-weighted MRI (DW-MRI) in differentiating residual bladder cancer from benign postoperative changes before a second transurethral resection of the bladder (TURB). MATERIALS AND METHODS: Of the 75 bladder cancer patients who underwent a second TURB from 2013 to 2015, 23 patients who underwent multi-sequence bladder MRI after their initial TURB were retrospectively evaluated. Thirty lesions were histologically examined at the second TURB and the results of them were compared with the findings obtained through T2-weighted MRI, dynamic contrast-enhanced MRI (DCE-MRI), and DW-MRI...
March 1, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28227865/a-dce-mri-imaging-based-model-for-simulation-of-vascular-tumour-growth
#20
Thais Roque, Veerle Kersemans, Sean Smart, Danny Allen, Julia A Schnabel, Michael Chappell, Thais Roque, Veerle Kersemans, Sean Smart, Danny Allen, Julia A Schnabel, Michael Chappell, Sean Smart, Michael Chappell, Veerle Kersemans, Danny Allen, Julia A Schnabel, Thais Roque
Imaging-based modelling of tumour growth can serve as a powerful tool to understand and predict tumour evolution and its response to therapy. The purpose of this study was to introduce, calibrate and evaluate a multi-scale model of vascular tumour growth. The model allows for proliferation, death and spatial spread of tumour cells as well as for new vessel creation. Both the calibration and the evaluation of the tumour growth model were performed using pre-clinical longitudinal time series of dynamic contrast-enhanced magnetic resonance imaging of colon carcinoma...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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