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https://www.readbyqxmd.com/read/28727225/intact-blood-brain-barrier-during-spontaneous-attacks-of-migraine-without-aura-a-3t-dce-mri-study
#1
F M Amin, A Hougaard, S P Cramer, C E Christensen, F Wolfram, H B W Larsson, M Ashina
BACKGROUND AND PURPOSE: The integrity of the blood-brain barrier (BBB) has been questioned in migraine, but BBB permeability has never been investigated during spontaneous migraine attacks. In the present study, BBB permeability during spontaneous attacks of migraine without aura was investigated compared to an interictal state. METHODS: Seventy-four patients suffering from migraine without aura were recruited to participate in this cross-sectional dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) study...
July 20, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28727185/automation-of-pattern-recognition-analysis-of-dynamic-contrast-enhanced-mri-data-to-characterize-intratumoral-vascular-heterogeneity
#2
SoHyun Han, Radka Stoyanova, Hansol Lee, Sean D Carlin, Jason A Koutcher, HyungJoon Cho, Ellen Ackerstaff
PURPOSE: To automate dynamic contrast-enhanced MRI (DCE-MRI) data analysis by unsupervised pattern recognition (PR) to enable spatial mapping of intratumoral vascular heterogeneity. METHODS: Three steps were automated. First, the arrival time of the contrast agent at the tumor was determined, including a calculation of the precontrast signal. Second, four criteria-based algorithms for the slice-specific selection of number of patterns (NP) were validated using 109 tumor slices from subcutaneous flank tumors of five different tumor models...
July 20, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28725592/is-contrast-enhancement-needed-for-diagnostic-prostate-mri
#3
REVIEW
Michele Scialpi, Valeria Rondoni, Maria Cristina Aisa, Eugenio Martorana, Alfredo D'Andrea, Corrado Maria Malaspina, Agostino Orlandi, Giorgio Galassi, Emanuele Orlandi, Pietro Scialpi, Michele Dragone, Diego Palladino, Annalisa Simeone, Michele Amenta, Giampaolo Bianchi
Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) provides clinical guidelines for multiparametric magnetic resonance imaging (mpMRI) [T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)] of prostate. However, DCE-MRI seems to show a limited contribution in prostate cancer (PCa) detection and management. In our experience, DCE-MRI, did not show significant change in diagnostic performance in addition to DWI and T2WI [biparametric MRI (bpMRI)] which represent the predominant sequences to detect suspected lesions in peripheral and transitional zone (TZ)...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28721456/antiangiogenic-tyrosine-kinase-inhibitors-in-colorectal-cancer-is-there-a-path-to-making-them-more-effective
#4
REVIEW
Thomas B Karasic, Mark A Rosen, Peter J O'Dwyer
Antiangiogenic therapy has a proven survival benefit in metastatic colorectal cancer. Inhibition of the VEGF pathway using a variety of extracellular antibody approaches has clear benefit in combination with chemotherapy, while intracellular blockade using tyrosine kinase inhibitors (TKIs) such as sorafenib and regorafenib has had more limited success. Pharmacodynamic modeling using modalities such as DCE-MRI indicates potent antiangiogenic effects of these TKIs, yet numerous combination therapies, primarily with chemotherapy, have failed to demonstrate an additive benefit...
July 18, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28721448/-pi-rads-2-0-for-prostate-mri
#5
T Franiel, M Röthke
The PI-RADS 2.0 classification was established by an international collaboration of the European Society of Urogenital Radiology (ESUR), the American College of Radiology (ACR), and AdMetech Foundation to globally standardize the acquisition and interpretation of multiparametric prostate magnetic resonance imaging (MRI). The PI-RADS 2.0 aims to improve the detection, localization, staging and risk stratification of patients with suspected or histologically confirmed prostate cancer. Suspicious areas on T2-weighted (T2w) MRI, diffusion-weighted MRI (DWI) and dynamic contrast-enhanced MRI (DCE-MRI) were assessed for the presence of a clinically significant prostate cancer with scale from 1 to 5 with 5 being most likely to represent clinically significant prostate cancer...
July 18, 2017: Der Radiologe
https://www.readbyqxmd.com/read/28720413/multiparametric-magnetic-resonance-imaging-of-the-prostate-for-tumour-detection-and-local-staging-imaging-in-1-5t-and-histopathologic-correlation
#6
Dimitra Loggitsi, Anastasios Gyftopoulos, Nikolaos Economopoulos, Aikaterini Apostolaki, Theodoros Kalogeropoulos, Anastasios Thanos, Efthimia Alexopoulou, Nikolaos L Kelekis
PURPOSE: The study sought to prospectively evaluate which technique among T2-weighted images, dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), diffusion-weighted (DW) MRI, or a combination of the 2, is best suited for prostate cancer detection and local staging. METHODS: Twenty-seven consecutive patients with biopsy-proven adenocarcinoma of the prostate underwent MRI on a 1.5T scanner with a surface phased-array coil prior radical prostatectomy...
July 15, 2017: Canadian Association of Radiologists Journal, Journal L'Association Canadienne des Radiologistes
https://www.readbyqxmd.com/read/28712703/role-of-semi-quantitative-dynamic-contrast-enhanced-mr-imaging-in-characterization-and-grading-of-prostate-cancer
#7
See Hyung Kim, Mi Sun Choi, Mi Jung Kim, Young Hwan Kim, Seung Hyun Cho
OBJECTIVE: The study retrospectively assessed the diagnostic value of semi-quantitative dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) in characterization and grading of prostate cancer, with correlation to histopathological analysis. MATERIALS AND METHODS: 161 consecutive patients with prostate cancer underwent DCE MRI. 430 lesions, including 200 cancers with Gleason grade (GG) of 6 (n=25), 7 (n=112) and 8 or higher (n=63); 80 benign hyperplasia; and 150 healthy tissues were assessed using a histology-MRI correlation...
July 6, 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28712700/radiomic-analysis-of-dce-mri-for-prediction-of-response-to-neoadjuvant-chemotherapy-in-breast-cancer-patients
#8
Ming Fan, Guolin Wu, Hu Cheng, Juan Zhang, Guoliang Shao, Lihua Li
OBJECTIVES: To enhance the accurate prediction of the response to neoadjuvant chemotherapy (NAC) in breast cancer patients by using a quantitative analysis of dynamic enhancement magnetic resonance imaging (DCE-MRI). MATERIALS AND METHODS: A dataset of 57 cancer patients with breast DCE-MR images acquired before NAC was used. Among them, 47 patients were Responders, and 10 patients were non-Responders based on the RECIST criteria. The breast regions were segmented on the MR images, and a total of 158 radiomic features were computed to represent the morphologic, dynamic, and the texture of the tumors as well as the background parenchymal features...
June 28, 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28707311/dynamic-contrast-enhanced-mri-of-the-patellar-bone-how-to-quantify-perfusion
#9
Dirk H J Poot, Rianne A van der Heijden, Marienke van Middelkoop, Edwin H G Oei, Stefan Klein
PURPOSE: To identify the optimal combination of pharmacokinetic model and arterial input function (AIF) for quantitative analysis of blood perfusion in the patellar bone using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). MATERIALS AND METHODS: This method design study used a random subset of five control subjects from an Institutional Review Board (IRB)-approved case-control study into patellofemoral pain, scanned on a 3T MR system with a contrast-enhanced time-resolved imaging of contrast kinetics (TRICKS) sequence...
July 14, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28702787/multiparametric-magnetic-resonance-imaging-for-transition-zone-prostate-cancer-essential-findings-limitations-and-future-directions
#10
REVIEW
Sara Lewis, Cecilia Besa, Ally Rosen, Ardeshir R Rastinehad, Sahar Semann, Stephanie Hectors, Bachir Taouli
OBJECTIVE: Review the multiparametric MRI (mpMRI) findings of transition zone (TZ) prostate cancer (PCa) using T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and dynamic contrast-enhanced (DCE) MRI and to integrate mpMRI findings with clinical history, laboratory values, and histopathology. CONCLUSION: TZ prostate tumors are challenging to detect clinically and at MRI. mpMRI using the combination of sequences has the potential to improve accuracy of TZ cancer detection and staging...
July 12, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28693537/erratum-to-intratumoral-and-peritumoral-radiomics-for-the-pretreatment-prediction-of-pathological-complete-response-to-neoadjuvant-chemotherapy-based-on-breast-dce-mri
#11
Nathaniel M Braman, Maryam Etesami, Prateek Prasanna, Christina Dubchuk, Hannah Gilmore, Pallavi Tiwari, Donna Plecha, Anant Madabhushi
No abstract text is available yet for this article.
July 10, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28692137/portable-perfusion-phantom-for-quantitative-dce-mri-of-the-abdomen
#12
Harrison Kim, Mina Mousa, Patrick Schexnailder, Robert Hergenrother, Mark Bolding, Bernard Ntsikoussalabongui, Vinoy Thomas, Desiree E Morgan
PURPOSE: To develop a portable perfusion phantom and validate its utility in quantitative dynamic contrast-enhanced magnetic resonance imaging of the abdomen. METHODS: A portable perfusion phantom yielding a reproducible contrast enhancement curve (CEC) was developed. A phantom package including perfusion and static phantoms were imaged simultaneously with each of three healthy human volunteers in two different 3T MR scanners. Look-up tables correlating reference (known) contrast concentrations with measured ones were created using either the static or perfusion phantom...
July 10, 2017: Medical Physics
https://www.readbyqxmd.com/read/28691102/dce-mri-texture-features-for-early-prediction-of-breast-cancer-therapy-response
#13
Guillaume Thibault, Alina Tudorica, Aneela Afzal, Stephen Y-C Chui, Arpana Naik, Megan L Troxell, Kathleen A Kemmer, Karen Y Oh, Nicole Roy, Neda Jafarian, Megan L Holtorf, Wei Huang, Xubo Song
This study investigates the effectiveness of hundreds of texture features extracted from voxel-based dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parametric maps for early prediction of breast cancer response to neoadjuvant chemotherapy (NAC). In total, 38 patients with breast cancer underwent DCE-MRI before (baseline) and after the first of the 6-8 NAC cycles. Quantitative pharmacokinetic (PK) parameters and semiquantitative metrics were estimated from DCE-MRI time-course data. The residual cancer burden (RCB) index value was computed based on pathological analysis of surgical specimens after NAC completion...
March 2017: Tomography: a Journal for Imaging Research
https://www.readbyqxmd.com/read/28683759/intravenous-neutralization-of-vascular-endothelial-growth-factor-reduces-vascular-function-permeability-of-the-ovary-and-prevents-development-of-ohss-like-symptoms-in-rhesus-monkeys
#14
C V Bishop, D M Lee, O D Slayden, X Li
BACKGROUND: Ovarian hyperstimulation syndrome (OHSS) is a disorder associated with elevated serum VEGFA following chorionic gonadotropin (hCG) exposure in controlled ovarian stimulation (COS) cycles in women. In this study, we tested the effect of intravenous VEGFA neutralization on OHSS-like symptoms and vascular function in rhesus macaques during COS cycles. METHODS: Monkeys (n = 8) were treated with 3 COS protocols and assigned randomly to groups as follows: 1) COS alone (Control, n = 5); 2) COS + VEGF mAb Avastin 19 ± 5 h before hCG (Avastin pre-hCG; n = 6); 3) COS + Avastin 3-4 days post-hCG (Avastin post-hCG; n = 4); 4) COS + Simulated Early Pregnancy (SEP n = 3); or 5) COS + SEP + Avastin (SEP + Avastin n = 3)...
July 6, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28681074/statistical-clustering-of-parametric-maps-from-dynamic-contrast-enhanced-mri-and-an-associated-decision-tree-model-for-non-invasive-tumour-grading-of-t1b-solid-clear-cell-renal-cell-carcinoma
#15
Yin Xi, Qing Yuan, Yue Zhang, Ananth J Madhuranthakam, Michael Fulkerson, Vitaly Margulis, James Brugarolas, Payal Kapur, Jeffrey A Cadeddu, Ivan Pedrosa
OBJECTIVES: To apply a statistical clustering algorithm to combine information from dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) into a single tumour map to distinguish high-grade from low-grade T1b clear cell renal cell carcinoma (ccRCC). METHODS: This prospective, Institutional Review Board -approved, Health Insurance Portability and Accountability Act -compliant study included 18 patients with solid T1b ccRCC who underwent pre-surgical DCE MRI...
July 5, 2017: European Radiology
https://www.readbyqxmd.com/read/28670153/influence-of-b1-inhomogeneity-on-pharmacokinetic-modeling-of-dynamic-contrast-enhanced-mri-a-simulation-study
#16
Bumwoo Park, Byung Se Choi, Yu Sub Sung, Dong-Cheol Woo, Woo Hyun Shim, Kyung Won Kim, Yoon Seok Choi, Sang Joon Pae, Ji-Yeon Suh, Hyungjoon Cho, Jeong Kon Kim
OBJECTIVE: To simulate the B1-inhomogeneity-induced variation of pharmacokinetic parameters on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). MATERIALS AND METHODS: B1-inhomogeneity-induced flip angle (FA) variation was estimated in a phantom study. Monte Carlo simulation was performed to assess the FA-deviation-induced measurement error of the pre-contrast R1, contrast-enhancement ratio, Gd-concentration, and two-compartment pharmacokinetic parameters (K(trans), ve, and vp)...
July 2017: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/28669014/temporal-evolution-of-perfusion-parameters-in-brain-metastases-treated-with-stereotactic-radiosurgery-comparison-of-intravoxel-incoherent-motion-and-dynamic-contrast-enhanced-mri
#17
Anish Kapadia, Hatef Mehrabian, John Conklin, Sean P Symons, Pejman J Maralani, Greg J Stanisz, Arjun Sahgal, Hany Soliman, Chinthaka C Heyn
Intravoxel incoherent motion (IVIM) is a magnetic resonance imaging (MRI) technique that is seeing increasing use in neuro-oncology and offers an alternative to contrast-enhanced perfusion techniques for evaluation of tumor blood volume after stereotactic radiosurgery (SRS). To date, IVIM has not been validated against contrast enhanced techniques for brain metastases after SRS. In the present study, we measure blood volume for 20 brain metastases (15 patients) at baseline, 1 week and 1 month after SRS using IVIM and dynamic contrast enhanced (DCE)-MRI...
July 1, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28668420/quantitative-in-vivo-imaging-of-tissue-factor-expression-in-glioma-using-dynamic-contrast-enhanced-mri-derived-parameters
#18
Xiao Chen, Tian Xie, Jingqin Fang, Wei Xue, Haipeng Tong, Houyi Kang, Sumei Wang, Yizeng Yang, Minhui Xu, Weiguo Zhang
OBJECTIVE: Tissue Factor (TF) has been well established in angiogenesis, invasion, metastasis, and prognosis in glioma. A noninvasive assessment of TF expression status in glioma is therefore of obvious clinical relevance. Dynamic contrast-enhanced (DCE) MRI parameters have been used to evaluate microvascular characteristics and predict molecular expression status in tumors. Our aim is to investigate whether quantitative DCE-MRI parameters could assess TF expression in glioma. MATERIALS AND METHODS: Thirty-two patients with histopathologically diagnosed supratentorial glioma who underwent DCE-MRI were retrospectively recruited...
August 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28661554/differentiation-of-olfactory-neuroblastomas-from-nasal-squamous-cell-carcinomas-using-mr-diffusion-kurtosis-imaging-and-dynamic-contrast-enhanced-mri
#19
Zebin Xiao, Zuohua Tang, Jinwei Qiang, Wen Qian, Yufeng Zhong, Rong Wang, Jie Wang, Lingjie Wu, Wenlin Tang
PURPOSE: To evaluate the use of magnetic resonance (MR) diffusion kurtosis imaging (DKI) and dynamic contrast-enhanced MR imaging (DCE-MRI) in the differentiation of olfactory neuroblastomas (ONBs) from squamous cell carcinomas (SCCs). MATERIALS AND METHODS: DKI and DCE-MRI were performed in 17 patients with ONBs and 23 patients with SCCs on a 3T MR scanner. Parameters derived from DKI and DCE-MRI were measured and compared between ONBs and SCCs using an independent samples t-test...
June 29, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28661213/dynamic-contrast-enhanced-mri-of-the-microenvironment-of-pancreatic-adenocarcinoma-xenografts
#20
Catherine S Wegner, Anette Hauge, Jon-Vidar Gaustad, Lise Mari K Andersen, Trude G Simonsen, Kanthi Galappathi, Einar K Rofstad
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with poor outcome. Resistance to treatment is associated with impaired vascularity, extensive hypoxia, and interstitial hypertension. In this study, the potential of dynamic contrast-enhanced (DCE)-MRI as a method for assessing the microvascular density (MVD), the fraction of hypoxic tissue, and the interstitial fluid pressure (IFP) of PDACs was investigated. MATERIAL AND METHODS: Intramuscular BxPC-3, Capan-2, MIAPaCa-2, and Panc-1 PDAC xenografts were used as preclinical models of human PDACs...
June 29, 2017: Acta Oncologica
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