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https://www.readbyqxmd.com/read/28922524/dynamic-contrast-enhanced-mri-in-orbital-lymphoproliferative-disorders-effects-of-region-of-interest-selection-methods-on-time-efficiency-measurement-reproducibility-and-diagnostic-ability
#1
Wen Qian, Xiao-Quan Xu, Hao Hu, Guo-Yi Su, Jiang-Fen Wu, Hai-Bin Shi, Fei-Yun Wu
BACKGROUND: Previous studies indicated that dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) could serve as a useful biomarker for differentiating malignant from benign orbital lymphoproliferative disorders (OLPDs). PURPOSE: To investigate the influence of different region of interest (ROI) selection methods on the measurements of DCE-MRI parameters, and their diagnostic ability in discriminating malignant from benign OLPDs. STUDY TYPE: Retrospective study...
September 18, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28915312/dce-and-dw-mri-as-early-imaging-biomarkers-of-treatment-response-in-a-preclinical-model-of-triple-negative-breast-cancer
#2
Stephanie L Barnes, Anna G Sorace, Jennifer G Whisenant, J Oliver McIntyre, Hakmook Kang, Thomas E Yankeelov
This work evaluates quantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted MRI (DW-MRI) parameters as early biomarkers of response in a preclinical model of triple negative breast cancer (TNBC). The standard Tofts' model of DCE-MRI returns estimates of the volume transfer constant (K(trans) ) and the extravascular extracellular volume fraction (ve ). DW-MRI returns estimates of the apparent diffusion coefficient (ADC). Mice (n = 38) were injected subcutaneously with MDA-MB-231...
September 15, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28913930/accuracy-repeatability-and-interplatform-reproducibility-of-t1-quantification-methods-used-for-dce-mri-results-from-a-multicenter-phantom-study
#3
Octavia Bane, Stefanie J Hectors, Mathilde Wagner, Lori L Arlinghaus, Madhava P Aryal, Yue Cao, Thomas L Chenevert, Fiona Fennessy, Wei Huang, Nola M Hylton, Jayashree Kalpathy-Cramer, Kathryn E Keenan, Dariya I Malyarenko, Robert V Mulkern, David C Newitt, Stephen E Russek, Karl F Stupic, Alina Tudorica, Lisa J Wilmes, Thomas E Yankeelov, Yi-Fei Yen, Michael A Boss, Bachir Taouli
PURPOSE: To determine the in vitro accuracy, test-retest repeatability, and interplatform reproducibility of T1 quantification protocols used for dynamic contrast-enhanced MRI at 1.5 and 3 T. METHODS: A T1 phantom with 14 samples was imaged at eight centers with a common inversion-recovery spin-echo (IR-SE) protocol and a variable flip angle (VFA) protocol using seven flip angles, as well as site-specific protocols (VFA with different flip angles, variable repetition time, proton density, and Look-Locker inversion recovery)...
September 14, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28910821/vascular-disrupting-agent-in-pancreatic-and-hepatic-tumour-allografts-observations-of-location-dependent-efficacy-by-mri-microangiography-and-histomorphology
#4
Ting Yin, Yewei Liu, Ronald Peeters, Yuanbo Feng, Jie Yu, Uwe Himmelreich, Raymond Oyen, Yicheng Ni
BACKGROUND: Tumours growing in organs of different vascular environment could exhibit diverse responses to vascular disrupting agent (VDA). This study was aimed to identify in vivo imaging biomarkers for evaluation of pancreatic and hepatic tumours and comparison of their responses to a VDA Combretastatin A4 Phosphate (CA4P) using multiparametric MRI. METHODS: Male WAG/Rij rats were used for orthotopic pancreatic head tumour and hepatic tumour implantation; tumour growth was monitored by 3D isotropic MRI using a 3...
September 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28905411/joint-arterial-input-function-and-tracker-kinetic-parameter-estimation-from-undersampled-dynamic-contrast-enhanced-mri-using-a-model-consistency-constraint
#5
Yi Guo, Sajan Goud Lingala, Yannick Bliesener, R Marc Lebel, Yinghua Zhu, Krishna S Nayak
PURPOSE: To develop and evaluate a model-based reconstruction framework for joint arterial input function (AIF) and kinetic parameter estimation from undersampled brain tumor dynamic contrast-enhanced MRI (DCE-MRI) data. METHODS: The proposed method poses the tracer-kinetic (TK) model as a model consistency constraint, enabling the flexible inclusion of different TK models and TK solvers, and the joint estimation of the AIF. The proposed method is evaluated using an anatomic realistic digital reference object (DRO), and nine retrospectively down-sampled brain tumor DCE-MRI datasets...
September 14, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28903414/micro-hccs-in-rats-with-liver-cirrhosis-paradoxical-targeting-effects-with-vascular-disrupting-agent-ca4p
#6
Yewei Liu, Ting Yin, Frederik De Keyzer, Yuanbo Feng, Feng Chen, Jianjun Liu, Shaoli Song, Jie Yu, Vincent Vandecaveye, Johan Swinnen, Guy Bormans, Uwe Himmelreich, Raymond Oyen, Jian Zhang, Gang Huang, Yicheng Ni
We sought to investigate anticancer efficacy of a vascular disrupting agent (VDA) combretastatin A-4 phosphate (CA4P) in relation to tumor size among hepatocellular carcinomas (HCCs) in rats using magnetic resonance imaging (MRI) and postmortem techniques. Nineteen rats with 43 chemically-induced HCCs of 2.8-20.9 mm in size on liver cirrhosis received CA4P intravenously at 10 mg/kg. Tumor-diameter was measured by T2-weighted imaging (T2WI) to define microcancers (< 5 mm) versus larger HCCs. Vascular responses and tissue necrosis were detected by diffusion-weighted imaging (DWI), contrast-enhanced T1-weighted imaging (CE-T1WI) and dynamic contrast enhanced (DCE-) MRI, which were validated by microangiography and histopathology...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28901594/quantitative-evaluation-of-breast-cancer-response-to-neoadjuvant-chemotherapy-by-diffusion-tensor-imaging-initial-results
#7
Edna Furman-Haran, Noam Nissan, Verónica Ricart-Selma, Carmen Martinez-Rubio, Hadassa Degani, Julia Camps-Herrero
BACKGROUND: Diffusion tensor imaging (DTI) yields several parameters that have not been tested in response evaluation to neoadjuvant chemotherapy (NAC). PURPOSE: To evaluate and compare in reference to histopathology findings the ability of DTI and dynamic contrast-enhanced (DCE) MRI to monitor response to NAC. STUDY TYPE: Retrospective. POPULATION: Twenty patients treated with neoadjuvant chemotherapy. FIELD STRENGTH/SEQUENCE: 1...
September 13, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28894997/a-novel-framework-for-evaluating-the-image-accuracy-of-dynamic-mri-and-the-application-on-accelerated-breast-dce-mri
#8
Yuan Le, Marcel Dominik Nickel, Stephan Kannengiesser, Berthold Kiefer, Bruce Spottiswoode, Brian Dale, Victor Soon, Chen Lin
OBJECTIVE: To develop a novel framework for evaluating the accuracy of quantitative analysis on dynamic contrast-enhanced (DCE) MRI with a specific combination of imaging technique, scanning parameters, and scanner and software performance and to test this framework with breast DCE MRI with Time-resolved angiography WIth Stochastic Trajectories (TWIST). MATERIALS AND METHODS: Realistic breast tumor phantoms were 3D printed as cavities and filled with solutions of MR contrast agent...
September 11, 2017: Magma
https://www.readbyqxmd.com/read/28894197/a-multi-institutional-comparison-of-dynamic-contrast-enhanced-magnetic-resonance-imaging-parameter-calculations
#9
Rachel B Ger, Abdallah S R Mohamed, Musaddiq J Awan, Yao Ding, Kimberly Li, Xenia J Fave, Andrew L Beers, Brandon Driscoll, Hesham Elhalawani, David A Hormuth, Petra J van Houdt, Renjie He, Shouhao Zhou, Kelsey B Mathieu, Heng Li, Catherine Coolens, Caroline Chung, James A Bankson, Wei Huang, Jihong Wang, Vlad C Sandulache, Stephen Y Lai, Rebecca M Howell, R Jason Stafford, Thomas E Yankeelov, Uulke A van der Heide, Steven J Frank, Daniel P Barboriak, John D Hazle, Laurence E Court, Jayashree Kalpathy-Cramer, Clifton D Fuller
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) provides quantitative metrics (e.g. K(trans), ve) via pharmacokinetic models. We tested inter-algorithm variability in these quantitative metrics with 11 published DCE-MRI algorithms, all implementing Tofts-Kermode or extended Tofts pharmacokinetic models. Digital reference objects (DROs) with known K(trans) and ve values were used to assess performance at varying noise levels. Additionally, DCE-MRI data from 15 head and neck squamous cell carcinoma patients over 3 time-points during chemoradiotherapy were used to ascertain K(trans) and ve kinetic trends across algorithms...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28887206/reproducibility-and-relative-stability-in-magnetic-resonance-imaging-indices-of-tumor-vascular-physiology-over-a-period-of-24h-in-a-rat-9l-gliosarcoma-model
#10
Tavarekere N Nagaraja, Rasha Elmghirbi, Stephen L Brown, Lonni R Schultz, Ian Y Lee, Kelly A Keenan, Swayamprava Panda, Glauber Cabral, Tom Mikkelsen, James R Ewing
PURPOSE: The objective was to study temporal changes in tumor vascular physiological indices in a period of 24h in a 9L gliosarcoma rat model. METHODS: Fischer-344 rats (N=14) were orthotopically implanted with 9L cells. At 2weeks post-implantation, they were imaged twice in a 24h interval using dynamic contrast enhanced magnetic resonance imaging (DCE-MRI). Data-driven model-selection-based analysis was used to segment tumor regions with varying vascular permeability characteristics...
September 5, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28885207/effect-of-irreversible-electroporation-of%C3%A2-prostate-cancer-on-microcirculation-imaging-findings-in-contrast-enhanced-t1-weighted-3d-mri
#11
L P Beyer, B Pregler, N Verloh, K Brünn, M Haimerl, C Stroszczynski, E M Jung, P Wiggermann
OBJECTIVES: Irreversible electroporation (IRE) is a novel focal ablation technique applicable for treatment of prostate cancer (PCa). We aim to evaluate imaging findings of T1-weighted contrast-enhanced MRI after percutaneous IRE of low-risk PCa. METHODS: A total of 13 male patients underwent IRE of focal low-risk PCa and were included in this analysis. Prostate IRE was conducted using 2-4 electrodes being placed under CT-fluoroscopy guidance. Dynamic contrast-enhanced 3D isotropic fat-saturated T1-weighted MRI (DCE-MRI) was performed 24-72 hours before and 24-72 hours after ablation...
September 4, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28876982/preoperative-predicting-malignancy-in-breast-mass-like-lesions-value-of-adding-histogram-analysis-of-apparent-diffusion-coefficient-maps-to-dynamic-contrast-enhanced-magnetic-resonance-imaging-for-improving-confidence-level
#12
Hong-Li Liu, Min Zong, Han Wei, Jian-Juan Lou, Si-Qi Wang, Qi-Gui Zou, Hai-Bin Shi, Yan-Ni Jiang
OBJECTIVE: This study aims to find out the benefits of adding histogram analysis of apparent diffusion coefficient (ADC) maps onto dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in predicting breast malignancy. METHODS: This study included 95 patients who were found with breast mass-like lesions from January 2014 to March 2016 (47 benign and 48 malignant). These patients were estimated by both DCE-MRI and diffusion-weighted imaging (DWI) and classified into two groups, namely, the benign and the malignant...
September 6, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28867668/mri-protocol-optimization-for-quantitative-dce-mri-of-the-spine
#13
Cristina Lavini, Gem Kramer, Indra Pieters-den Bos, Otto Hoekstra, J Tim Marcus
PURPOSE: In this study we systematically investigated different Dynamic Contrast Enhancement (DCE)-MRI protocols in the spine, with the goal of finding an optimal protocol that provides data suitable for quantitative pharmacokinetic modelling (PKM). MATERIALS AND METHODS: In 13 patients referred for MRI of the spine, DCE-MRI of the spine was performed with 2D and 3D MRI protocols on a 3T Philips Ingenuity MR system. A standard bolus of contrast agent (Dotarem - 0...
September 1, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28864020/pre-clinical-evaluation-of-a-nanoparticle-based-blood-pool-contrast-agent-for-mr-imaging-of-the-placenta
#14
Ketan B Ghaghada, Zbigniew A Starosolski, Saakshi Bhayana, Igor Stupin, Chandreshkumar V Patel, Rohan C Bhavane, Haijun Gao, Andrey Bednov, Chandrasekhar Yallampalli, Michael Belfort, Verghese George, Ananth V Annapragada
INTRODUCTION: Non-invasive 3D imaging that enables clear visualization of placental margins is of interest in the accurate diagnosis of placental pathologies. This study investigated if contrast-enhanced MRI performed using a liposomal gadolinium blood-pool contrast agent (liposomal-Gd) enables clear visualization of the placental margins and the placental-myometrial interface (retroplacental space). Non-contrast MRI and contrast-enhanced MRI using a clinically approved conventional contrast agent were used as comparators...
September 2017: Placenta
https://www.readbyqxmd.com/read/28862024/differentiation-of-grade-ii-and-iii-oligodendrogliomas-from-grade-ii-and-iii-astrocytomas-a-histogram-analysis-of-perfusion-parameters-derived-from-dynamic-contrast-enhanced-dce-and-dynamic-susceptibility-contrast-dsc-mri
#15
Ji Young Lee, Kook Jin Ahn, Youn Soo Lee, Jin Hee Jang, So Lyung Jung, Bum Soo Kim
Background Since oligodendroglial tumors are sensitive to chemotherapy and have a better prognosis, the differentiation of oligodendroglial tumors (OT) from astrocytic tumors (AT) is important. Purpose To investigate the perfusion and permeability parameters that differentiate grade II and III OT from AT, using dynamic contrast-enhanced (DCE) and dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI). Material and Methods We retrospectively reviewed the DCE and DSC MRIs of 39 patients with OT (OTs, n = 19; grade II, n = 12 and grade III, n = 7) and AT (ATs, n = 20; grade II, n = 7 and grade III, n = 13)...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28858856/impact-of-fitting-algorithms-on-errors-of-parameter-estimates-in-dynamic-contrast-enhanced-mri
#16
Charlotte Debus, Ralf Floca, Dominik Nörenberg, Amir Abdollahi, Michael Ingrisch
Parameter estimation in dynamic contrast-enhanced MRI (DCE MRI) is usually performed by non-linear least square (NLLS) fitting of a pharmacokinetic model to a measured concentration-time curve. The two-compartment exchange model (2CXM) describes the compartments "plasma" and "interstitial volume" and their exchange in terms of plasma flow and capillary permeability. The model function can be defined by either a system of two coupled differential equations or a closed-form analytical solution. The aim of this study was to compare these two representations in terms of accuracy, robustness and computation speed, depending on parameter combination and temporal sampling...
August 31, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28856728/data-driven-mapping-of-hypoxia-related-tumor-heterogeneity-using-dce-mri-and-oe-mri
#17
Adam K Featherstone, James P B O'Connor, Ross A Little, Yvonne Watson, Sue Cheung, Muhammad Babur, Kaye J Williams, Julian C Matthews, Geoff J M Parker
PURPOSE: Previous work has shown that combining dynamic contrast-enhanced (DCE)-MRI and oxygen-enhanced (OE)-MRI binary enhancement maps can identify tumor hypoxia. The current work proposes a novel, data-driven method for mapping tissue oxygenation and perfusion heterogeneity, based on clustering DCE/OE-MRI data. METHODS: DCE-MRI and OE-MRI were performed on nine U87 (glioblastoma) and seven Calu6 (non-small cell lung cancer) murine xenograft tumors. Area under the curve and principal component analysis features were calculated and clustered separately using Gaussian mixture modelling...
August 30, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28856410/dynamic-contrast-enhanced-and-diffusion-weighted-mr-imaging-in-the-characterisation-of-small-non-palpable-solid-testicular-tumours
#18
Lucia Manganaro, Matteo Saldari, Carlotta Pozza, Valeria Vinci, Daniele Gianfrilli, Ermanno Greco, Giorgio Franco, Maria Eleonora Sergi, Michele Scialpi, Carlo Catalano, Andrea M Isidori
OBJECTIVES: To explore the role of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), using semiquantitative and quantitative parameters, and diffusion-weighted (DW) MRI in differentiating benign from malignant small, non-palpable solid testicular tumours. METHODS: We calculated the following DCE-MRI parameters of 47 small, non-palpable solid testicular tumours: peak enhancement (PE), time to peak (TTP), percentage of peak enhancement (Epeak), wash-in-rate (WIR), signal enhancement ratio (SER), volume transfer constant (Ktrans), rate constant (Kep), extravascular extracellular space volume fraction (Ve) and initial area under the curve (iAUC)...
August 30, 2017: European Radiology
https://www.readbyqxmd.com/read/28851989/delineation-of-tumor-habitats-based-on-dynamic-contrast-enhanced-mri
#19
Yu-Cherng Channing Chang, Ellen Ackerstaff, Yohann Tschudi, Bryan Jimenez, Warren Foltz, Carl Fisher, Lothar Lilge, HyungJoon Cho, Sean Carlin, Robert J Gillies, Yoganand Balagurunathan, Raphael L Yechieli, Ty Subhawong, Baris Turkbey, Alan Pollack, Radka Stoyanova
Tumor heterogeneity can be elucidated by mapping subregions of the lesion with differential imaging characteristics, called habitats. Dynamic Contrast Enhanced (DCE-)MRI can depict the tumor microenvironments by identifying areas with variable perfusion and vascular permeability, since individual tumor habitats vary in the rate and magnitude of the contrast uptake and washout. Of particular interest is identifying areas of hypoxia, characterized by inadequate perfusion and hyper-permeable vasculature. An automatic procedure for delineation of tumor habitats from DCE-MRI was developed as a two-part process involving: (1) statistical testing in order to determine the number of the underlying habitats; and (2) an unsupervised pattern recognition technique to recover the temporal contrast patterns and locations of the associated habitats...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28845594/textural-features-of-dynamic-contrast-enhanced-mri-derived-model-free-and-model-based-parameter-maps-in-glioma-grading
#20
Tian Xie, Xiao Chen, Jingqin Fang, Houyi Kang, Wei Xue, Haipeng Tong, Peng Cao, Sumei Wang, Yizeng Yang, Weiguo Zhang
BACKGROUND: Presurgical glioma grading by dynamic contrast-enhanced MRI (DCE-MRI) has unresolved issues. PURPOSE: The aim of this study was to investigate the ability of textural features derived from pharmacokinetic model-based or model-free parameter maps of DCE-MRI in discriminating between different grades of gliomas, and their correlation with pathological index. STUDY TYPE: Retrospective. SUBJECTS: Forty-two adults with brain gliomas...
August 28, 2017: Journal of Magnetic Resonance Imaging: JMRI
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