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https://www.readbyqxmd.com/read/29777820/accuracy-and-precision-of-quantitative-dce-mri-parameters-how-should-one-estimate-contrast-concentration
#1
Nicole Wake, Hersh Chandarana, Henry Rusinek, Koji Fujimoto, Linda Moy, Daniel K Sodickson, Sungheon Gene Kim
INTRODUCTION: Pharmacokinetic parameters derived from dynamic contrast-enhanced MRI (DCE-MRI) data are sensitive to acquisition and post-processing techniques, which makes it difficult to compare results obtained using different methods. In particular, one of the most important factors affecting estimation of model parameters is how to convert MRI signal intensities to contrast agent concentration. The purpose of our study was to quantitatively compare a linear signal-to-concentration conversion (LC) as an approximation and a non-linear conversion (NLC) based on the MRI signal equation, in terms of the accuracy and precision of the pharmacokinetic parameters in T1 -weighted DCE-MRI...
May 16, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29774398/improved-detection-of-a-tumorous-involvement-of-the-mesorectal-fascia-and-locoregional-lymph-nodes-in-locally-advanced-rectal-cancer-using-dce-mri
#2
Marco Armbruster, Melvin D'Anastasi, Veronika Holzner, Martin E Kreis, Olaf Dietrich, Bernhard Brandlhuber, Anno Graser, Martina Brandlhuber
PURPOSE: The prediction of an infiltration of the mesorectal fascia (MRF) and malignant lymph nodes is essential for treatment planning and prognosis of patients with rectal cancer. The aim of this study was to assess the additional diagnostic value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for the detection of a malignant involvement of the MRF and of mesorectal lymph nodes in patients with locally advanced rectal cancer. METHODS: In this prospective study, 22 patients with locally advanced rectal cancer were examined with 1...
May 17, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29771954/preoperative-prediction-of-microvascular-invasion-of-hepatocellular-carcinoma-with-ivim-diffusion-weighted-mr-imaging-and-gd-eob-dtpa-enhanced-mr-imaging
#3
Wei Zhao, Wenguang Liu, Huaping Liu, Xiaoping Yi, Jiale Hou, Yigang Pei, Hui Liu, Deyun Feng, Liyu Liu, Wenzheng Li
Microvascular invasion (MVI) is regarded as one of the independent risk factors for recurrence and poor prognosis of hepatocellular carcinoma (HCC). The presence of MVI in HCCs was evaluated on the basis of pathological reports of surgical specimens and was defined as tumor within a vascular space lined by endothelium that was visible only on microscopy. The aim of the study was to investigate the usefulness of intravoxel incoherent motion (IVIM) diffusion weighted (DW) magnetic resonance (MR) imaging in predicting MVI of HCC...
2018: PloS One
https://www.readbyqxmd.com/read/29771932/a-multi-center-preclinical-study-of-gadoxetate-dce-mri-in-rats-as-a-biomarker-of-drug-induced-inhibition-of-liver-transporter-function
#4
Anastassia Karageorgis, Stephen C Lenhard, Brittany Yerby, Mikael F Forsgren, Serguei Liachenko, Edvin Johansson, Mark A Pilling, Richard A Peterson, Xi Yang, Dominic P Williams, Sharon E Ungersma, Ryan E Morgan, Kim L R Brouwer, Beat M Jucker, Paul D Hockings
Drug-induced liver injury (DILI) is a leading cause of acute liver failure and transplantation. DILI can be the result of impaired hepatobiliary transporters, with altered bile formation, flow, and subsequent cholestasis. We used gadoxetate dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), combined with pharmacokinetic modelling, to measure hepatobiliary transporter function in vivo in rats. The sensitivity and robustness of the method was tested by evaluating the effect of a clinical dose of the antibiotic rifampicin in four different preclinical imaging centers...
2018: PloS One
https://www.readbyqxmd.com/read/29770495/prostate-dce-mri-with-b1-correction-using-an-approximated-analytical-approach
#5
Xinran Zhong, Thomas Martin, Holden H Wu, Krishna S Nayak, Kyunghyun Sung
PURPOSE: To develop and evaluate a practical B1+ correction method for prostate dynamic contrast-enhanced (DCE) MRI analysis. THEORY: We proposed a simple analytical B1+ correction method using a Taylor series approximation to the steady-state spoiled gradient echo signal equation. This approach only requires B1+ maps and uncorrected pharmacokinetic (PK) parameters as input to estimate the corrected PK parameters. METHODS: The proposed method was evaluated using a prostate digital reference object (DRO), and 82 in vivo prostate DCE-MRI cases...
May 16, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29766930/measurement-of-the-permeability-perfusion-and-histogram-characteristics-in-relapsing-remitting-multiple-sclerosis-using-dynamic-contrast-enhanced-mri-with-extended-tofts-linear-model
#6
Ping Yin, Hua Xiong, Yi Liu, Shambhu K Sah, Chun Zeng, Jingjie Wang, Yongmei Li, Nan Hong
Objective: To investigate the application value of using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with extended Tofts linear model for relapsing-remitting multiple sclerosis (RRMS) and its correlation with expanded disability status scale (EDSS) scores and disease duration. Materials and Methods: Thirty patients with multiple sclerosis (MS) underwent conventional magnetic resonance imaging (MRI) and DCE-MRI with a 3.0 Tesla MR scanner. An extended Tofts linear model was used to quantitatively measure MR imaging biomarkers...
May 2018: Neurology India
https://www.readbyqxmd.com/read/29766921/quantification-of-blood-brain-barrier-using-dce-mri-in-multiple-sclerosis-technical-issues-and-its-possible-role-in-routine-clinical-practice
#7
EDITORIAL
https://www.readbyqxmd.com/read/29765520/histogram-analysis-parameters-of-dynamic-contrast-enhanced-magnetic-resonance-imaging-can-predict-histopathological-findings-including-proliferation-potential-cellularity-and-nucleic-areas-in-head-and-neck-squamous-cell-carcinoma
#8
Alexey Surov, Hans Jonas Meyer, Leonard Leifels, Anne-Kathrin Höhn, Cindy Richter, Karsten Winter
Our purpose was to analyze possible associations between histogram analysis parameters of dynamic contrast-enhanced magnetic resonance imaging DCE MRI and histopathological findings like proliferation index, cell count and nucleic areas in head and neck squamous cell carcinoma (HNSCC). 30 patients (mean age 57.0 years) with primary HNSCC were included in the study. In every case, histogram analysis parameters of Ktrans , Ve , and Kep were estimated using a mathlab based software. Tumor proliferation index, cell count, and nucleic areas were estimated on Ki 67 antigen stained specimens...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29754996/dce-mri-in-human-gliomas-a-surrogate-for-assessment-of-invasive-hypoxia-marker-hif-1%C3%AE-based-on-mri-neuronavigation-stereotactic-biopsies
#9
Qian Xie, Juan Wu, Zunguo Du, Ningning Di, Ren Yan, Haopeng Pang, Teng Jin, Hua Zhang, Yue Wu, Yong Zhang, Zhenwei Yao, Xiaoyuan Feng
RATIONALE AND OBJECTIVES: The purpose of this study was to correlate dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters with data from a specific marker of hypoxia, hypoxia-inducible factor 1α (HIF-1α), in human gliomas on a point-to-point basis by using coregistered magnetic resonance imaging and frameless stereotactic biopsies. MATERIALS AND METHODS: Thirty-four patients with treatment-naive gliomas underwent DCE, axial T1-weighted, T2-weighted, T2-weighted fluid acquisition of inversion recovery, and three-dimensional T1-weighted brain volume with gadolinium contrast enhancement sequences on a 3...
May 10, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29754871/dynamic-contrast-enhanced-mr-imaging-of-the-rectum-correlations-between-single-section-and-whole-tumor-histogram-analyses
#10
M H Choi, S N Oh, G E Park, D-M Yeo, S E Jung
PURPOSE: To evaluate the interobserver and intermethod correlations of histogram metrics of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters acquired by multiple readers using the single-section and whole-tumor volume methods. MATERIALS AND METHODS: Four DCE parameters (Ktrans , Kep , Ve , Vp ) were evaluated in 45 patients (31 men and 14 women; mean age, 61±11 years [range, 29-83 years]) with locally advanced rectal cancer using pre-chemoradiotherapy (CRT) MRI...
May 10, 2018: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/29752976/can-dynamic-contrast-enhanced-mri-evaluate-vegf-expression-in-brain-glioma-an-mri-guided-stereotactic-biopsy-study
#11
Ningning Di, Wenna Cheng, Xingyue Jiang, Xinjiang Liu, Jinliang Zhou, Qian Xie, Zhihui Chu, Huacheng Chen, Bin Wang
PURPOSE: To investigate whether pharmacokinetic parameters derived from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can be used to evaluate vascular endothelial growth factor (VEGF) expression in brain glioma based on a point-to-point basis. MATERIALS AND METHODS: Forty-seven patients with treatment-naïve glioma received preoperative DCE-MRI before stereotactic biopsy. We histologically quantified VEGF from section of stereotactic biopsies, and co-registered biopsy locations with localized measurements of DCE-MRI parameters including volume transfer coefficient (Ktrans ), reverse reflux rate constant (Kep), extracellular extravascular volume fraction (Ve) and blood plasma volume (Vp)...
May 9, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29745982/an-extended-reference-region-model-for-dce-mri-that-accounts-for-plasma-volume
#12
Zaki Ahmed, Ives R Levesque
The reference region model (RRM) for dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) provides pharmacokinetic parameters without requiring the arterial input function. A limitation of the RRM is that it assumes that the blood plasma volume in the tissue of interest is zero, but this is often not true in highly vascularized tissues, such as some tumours. This study proposes an extended reference region model (ERRM) to account for tissue plasma volume. Furthermore, ERRM was combined with a two-fit approach to reduce the number of fitting parameters, and this was named the constrained ERRM (CERRM)...
May 10, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29744935/fast-magnetic-resonance-fingerprinting-for-dynamic-contrast-enhanced-studies-in-mice
#13
Yuning Gu, Charlie Y Wang, Christian E Anderson, Yuchi Liu, He Hu, Mette L Johansen, Dan Ma, Yun Jiang, Ciro Ramos-Estebanez, Susann Brady-Kalnay, Mark A Griswold, Chris A Flask, Xin Yu
PURPOSE: The goal of this study was to develop a fast MR fingerprinting (MRF) method for simultaneous T1 and T2 mapping in DCE-MRI studies in mice. METHODS: The MRF sequences based on balanced SSFP and fast imaging with steady-state precession were implemented and evaluated on a 7T preclinical scanner. The readout used a zeroth-moment-compensated variable-density spiral trajectory that fully sampled the entire k-space and the inner 10 × 10 k-space with 48 and 4 interleaves, respectively...
May 9, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29739827/hyperfiltration-in-ubiquitin-c-terminal-hydrolase-l1-deleted-mice
#14
Naomi C Boisvert, Chet E Holterman, Jean-François Thibodeau, Rania Nasrallah, Eldjonai Kamto, Cesar H Comin, Luciano da F Costa, Anthony Carter, Richard L Hébert, Alexey Gutsol, Gregory O Cron, Baptiste Lacoste, Douglas A Gray, Chris R Kennedy
Neuronal ubiquitin C-terminal hydrolase L1 (UCHL1) is a deubiquitinating enzyme that maintains intracellular ubiquitin pools and promotes axonal transport. Uchl1 deletion in mice leads to progressive axonal degeneration, affecting the dorsal root ganglion that harbours axons emanating to the kidney. Innervation is a crucial regulator of renal hemodynamics, though the contribution of neuronal UCHL1 to this is unclear. Immunofluorescence revealed significant neuronal UCHL1 expression in mouse kidney, including periglomerular axons...
May 8, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29734499/blood-perfusion-of-patellar-bone-measured-by-dynamic-contrast-enhanced-mri-in-patients-with-patellofemoral-pain-a-case-control-study
#15
Rianne A van der Heijden, Dirk H J Poot, Melek Ekinci, Gyula Kotek, Peter L J van Veldhoven, Stefan Klein, Jan A N Verhaar, Gabriel P Krestin, Sita M A Bierma-Zeinstra, Marienke van Middelkoop, Edwin H G Oei
BACKGROUND: Altered perfusion might play an important role in the pathophysiology of patellofemoral pain (PFP), a common knee complaint with unclear pathophysiology. PURPOSE: To investigate differences in dynamic contrast-enhanced (DCE)-MRI perfusion parameters between patients with PFP and healthy control subjects. POPULATION/SUBJECTS/PHANTOM/SPECIMEN/ANIMAL MODEL: Thirty-five adult patients with PFP and 44 healthy adult control subjects...
May 7, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29734493/assessment-of-breast-mass-morphology-with-diffusion-weighted-mri-beyond-apparent-diffusion-coefficient
#16
Sibel Kul, Yavuz Metin, Musa Kul, Nurgul Metin, Ilker Eyuboglu, Oguzhan Ozdemir
BACKGROUND: Diffusion-weighted imaging (DWI) is a noncontrast-enhanced MRI technique. There are new promising studies on the use of DWI as a part of the enhanced or unenhanced abbreviated breast MRI protocols. PURPOSE: To evaluate the ability of breast DWI in the assessment of mass morphology and determine the contribution of this morphologic evaluation in their characterization. STUDY TYPE: Retrospective. POPULATION: In all, 213 consecutive women were breast MR imaged and had a later confirmed diagnosis...
May 7, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29734483/role-of-dynamic-contrast-enhanced-mri-in-evaluating-the-association-between-contralateral-parenchymal-enhancement-and-survival-outcome-in-er-positive-her2-negative-node-negative-invasive-breast-cancer
#17
Gi Won Shin, Yang Zhang, Min Jung Kim, Min-Ying Su, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Vivian Youngjean Park
BACKGROUND: Background parenchymal enhancement (BPE) on dynamic contrast-enhanced (DCE)-MRI has been associated with breast cancer risk, both based on qualitative and quantitative assessments. PURPOSE: To investigate whether BPE of the contralateral breast on preoperative DCE-MRI is associated with therapy outcome in ER-positive, HER2-negative, node-negative invasive breast cancer. STUDY TYPE: Retrospective. POPULATION: In all, 289 patients with unilateral ER-positive, HER2-negative, node-negative breast cancer larger than 5 mm...
May 7, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29732345/automatic-prostate-cancer-segmentation-using-kinetic-analysis-in-dynamic-contrast-enhanced-mri
#18
S Navaei Lavasani, A Mostaar, M Ashtiyani
Background: Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) provides functional information on the microcirculation in tissues by analyzing the enhancement kinetics which can be used as biomarkers for prostate lesions detection and characterization. Objective: The purpose of this study is to investigate spatiotemporal patterns of tumors by extracting semi-quantitative as well as wavelet-based features, both extracted from pixel-based time-signal intensity curves to segment prostate lesions on prostate DCE-MRI...
March 2018: Journal of Biomedical Physics & Engineering
https://www.readbyqxmd.com/read/29731779/early-changes-in-tumor-perfusion-from-t1-weighted-dynamic-contrast-enhanced-mri-following-neural-stem-cell-mediated-therapy-of-recurrent-high-grade-glioma-correlate-with-overall-survival
#19
Prativa Sahoo, Paul Frankel, Julie Ressler, Margarita Gutova, Alexander J Annala, Behnam Badie, Jana Portnow, Karen S Aboody, Massimo D'Apuzzo, Russell C Rockne
Background: The aim of this study was to correlate T1-weighted dynamic contrast-enhanced MRI- (DCE-MRI-) derived perfusion parameters with overall survival of recurrent high-grade glioma patients who received neural stem cell- (NSC-) mediated enzyme/prodrug gene therapy. Methods: A total of 12 patients were included in this retrospective study. All patients were enrolled in a first-in-human study (NCT01172964) of NSC-mediated therapy for recurrent high-grade glioma...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29729392/imaging-vascular-and-hemodynamic-features-of-the-brain-using-dynamic-susceptibility-contrast-and-dynamic-contrast-enhanced-mri
#20
C Chad Quarles, Laura C Bell, Ashley M Stokes
In the context of neurologic disorders, dynamic susceptibility contrast (DSC) and dynamic contrast enhanced (DCE) MRI provide valuable insights into cerebral vascular function, integrity, and architecture. Even after two decades of use, these modalities continue to evolve as their biophysical and kinetic basis is better understood, with improvements in pulse sequences and accelerated imaging techniques and through application of more robust and automated data analysis strategies. Here, we systematically review each of these elements, with a focus on how their integration improves kinetic parameter accuracy and the development of new hemodynamic biomarkers that provide sub-voxel sensitivity (e...
May 2, 2018: NeuroImage
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