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Liver transplant paf

Alberto A Marcacuzco Quinto, Alejandro Manrique Municio, Luis C Jimenez Romero, Carmelo Loinaz Segurola, Jorge Calvo Pulido, Iago Justo Alonso, Alvaro Garcia-Sesma Perez-F, Manuel Abradelo de Usera, Felix Cambra Molero, Oscar Caso M, Enrique Moreno Gonzalez
BACKGROUND AND OBJECTIVE: Familial amyloid polyneuropathy (FAP) is the most prevalent type of hereditary systemic amyloidosis. It is an autosomal dominant disease characterized by the deposition of an abnormal variant transthyretin. It has a worldwide distribution, with localized endemic areas in Portugal, Sweden and Japan. In Spain there is an endemic focus, located in Mallorca. Liver transplantation is the only curative option for patients with FAP. The aim of this study was to describe the clinical and demographic characteristics of patients transplanted with a diagnosis of PAF...
May 8, 2015: Medicina Clínica
Seisho Sakai, Hidehiro Tajima, Tomoharu Miyashita, Shin-Ichi Nakanuma, Isamu Makino, Hironori Hayashi, Hisatoshi Nakagawara, Hirohisa Kitagawa, Sachio Fushida, Takashi Fujimura, Hidehito Saito, Seiichi Munesue, Yasuhiko Yamamoto, Tetsuo Ohta
BACKGROUND: Sivelestat sodium hydrate (sivelestat) is a specific neutrophil elastase inhibitor that is effective in treating acute lung injury associated with systemic inflammatory response syndrome. As such, it may be useful in treating hepatic ischemia-reperfusion injury (IRI), a condition in which neutrophils transmigrate into the interstitium, leading to release of neutrophil elastase from neutrophils and consequent damage to the affected tissue, particularly in cases of hepatic failure after liver transplantation or massive liver resection...
April 2014: Digestive Diseases and Sciences
Marina G M Castor, Bárbara M Rezende, Carolina B Resende, Priscila T T Bernardes, Daniel Cisalpino, Angélica T Vieira, Danielle G Souza, Tarcília A Silva, Mauro M Teixeira, Vanessa Pinho
PAF is a potent lipid mediator involved in several manifestations of acute inflammation, including leukocyte influx, leukocyte interaction with endothelium, and production of inflammatory cytokines. The present study evaluated the relevance of PAFR for the pathogenesis of acute GVHD using a model of adoptive transfer of splenocytes from WT or PAFR(-/-) C57BL/6J to B6D2F1 mice. Mice, which received PAFR(-/-) splenocytes or treatment with the PAFR antagonist, showed reduced clinical signs of disease and no mortality...
April 2012: Journal of Leukocyte Biology
Nikolaos-P Karidis, Gregory Kouraklis, Stamatios-E Theocharis
The hepatocyte, the main cellular component of the liver, exhibits variable susceptibility to different types of injury induced by endogenous or exogenous factors. Hepatocellular dysfunction or death and regeneration are dependent upon the complicated interactions between numerous biologically active molecules. Platelet-activating factor (PAF) seems to play a pivotal role as the key mediator of liver injury in the clinical and experimental setting, as implied by the beneficial effects of its receptor antagonists...
June 21, 2006: World Journal of Gastroenterology: WJG
Giuseppe Cicco, P C Panzera, G Catalano, V Memeo
There are many interesting aspects regarding hemorheology and tissue oxygenation in organ transplantation (such as liver, kidney, heart, etc.). The ischemia-reperfusion injury syndrome is a very important problem. Much damage in organs appears to be induced by reperfusion injury syndrome. In fact, not only immunological etiopathogenesis but also biochemically-mediated microcirculation alterations can modulate the organ damage induced by ischemia-reperfusion injury during organ transplantation. During ischemia-reperfusion injury, xanthine oxidase activity, the increase in oxygen free-radicals, and the activation of neuthrophils are all very important...
2005: Advances in Experimental Medicine and Biology
A Gattoni, F Marotta, B Vangieri, G Pisani, F Cristiano
PURPOSE: Discuss exhaustively the clinical aspects of hepatorenal syndrome (HRS), laboratory data, the progress made in understanding the pathogenesis, and treatment. DESIGN: The work is a result of the research conducted in the framework of the most important studies on HRS. RESULTS AND CONCLUSIONS: Functional renal failure (FRF) is the most severe manifestation of hepatorenal syndrome, and becomes manifest with a decreased renal perfusion along with oliguresis, reduced excretion of sodium, high urinary osmolarity, azotemia and creatinemia...
September 2004: La Clinica Terapeutica
Mireia M Ginesta, David G Mollevi, Teresa Serrano, Jordi Bas, Mariona Mestre, Yolanda Ribas, Joan Figueras, Eduardo Jaurrieta
PAF antagonists have been used in xenotransplantation to alleviate the pathogenesis of hyperacute rejection. This study evaluated the ability of the PAF antagonist UR-12670 to improve graft function in late xenograft rejection (LXR) in an orthotopic liver xenotransplantation model, and the involvement of PAF (platelet activating factor) in this type of rejection. The recipients of a hamster xenograft received standard immunosuppression (tacrolimus 0.2 mg/kg/30 days, MMF 25 mg/kg/8 days). Study groups: group A, without UR-12670, group B, UR-12670 (20 mg/kg/8 d) and group C, continuous administration of UR-12670 (20 mg/kg/d)...
March 2003: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
H Iwamoto, N Matsuno, Y Narumi, M Uchiyama, K Kozaki, H Degawa, K Hama, K Kikuchi, H Takeuchi, M Kozaki, T Nagao
No abstract text is available yet for this article.
November 2000: Transplantation Proceedings
M Gu, Y Takada, K Fukunaga, S Ishiguro, H Taniguchi, K Seino, K Yuzawa, M Otsuka, T Todoroki, K Fukao
BACKGROUND: Non-heart-beating donors (NHBDs) are considered potential sources of transplant organs in an effort to alleviate the problem of donor shortage in clinical liver transplantation. We investigated the possibility of pharmacologic protection of hepatic allograft function from NHBDs without donor pretreatment. METHODS: Orthotopic liver transplantation was performed using pigs. In donors, cardiac arrest was induced by stopping the respirator. Forty-five minutes after cessation of the respirator, the liver was flushed with cold lactated Ringer's solution including heparin and with the University of Wisconsin (UW) solution, and then preserved for 8 hr at 4 degrees C in the UW solution...
October 15, 2000: Transplantation
M Kunitomi, E Takayama, S Suzuki, T Yasuda, K Tsutsui, K Nagaike, S Hiroi, T Tadakuma
We constructed a plasmid containing human alpha-fetoprotein (AFP) promoter/enhancer to direct the cell type-specific expression of diphtheria toxin fragment A (DTA), designated as pAF-DTA, to AFP-producing hepatocellular carcinoma cells. The transfection was carried out with cationic liposomes (DMRIE-C) and the expression of the DTA gene was confirmed by a northern blot analysis. When pAF-DTA was transfected, the growth of AFP-positive HuH-7 cells was inhibited, whereas growth inhibition was not observed in AFP-negative MKN45 cells...
March 2000: Japanese Journal of Cancer Research: Gann
Y Takada, K Fukunaga, M Gu, S Ishiguro, H Taniguchi, K Seino, K Yuzawa, M Otsuka, K Fukao
No abstract text is available yet for this article.
March 2000: Transplantation Proceedings
K Fukunaga, Y Takada, H Taniguchi, K Yuzawa, M Otsuka, T Todoroki, K Goto, K Fukao
PROBLEM: The function of hepatic allograft from non-heartbeating donors (NHBD) is significantly affected by warm ischemic injury before harvesting. MATERIALS AND METHODS: The effects of the endothelin (ET) antagonist TAK-044 and the platelet activating factor (PAF) antagonist E5880 on the function of grafts from NHBD were evaluated in a porcine orthotopic liver transplantation. The liver grafts were subjected to 90 min of warm ischemia and 4 hours cold preservation...
July 1998: International Surgery
C Hammer, R Linke, D Seehofer, M Diefenbeck
The importance of this model is that it showed exactly where in the organ the xenogeneic damage occurred. The liver received the blood mainly via portal veins, which merge with the pulsatile arterioles in the Disse spaces. This periportal area is followed by the sinusoids and ends in the central or postsinusoidal vein. IVM enables us to differentiate between perfused and unperfused sinusoids and to calculate the ratio. Not all sinusoids are perfused at any time. It appears that 5% to 10% are unperfused. During xenoperfusion, only 65% of sinusoids show blood flow after a perfusion of 12 minutes...
December 1998: Transplantation Proceedings
K Fukunaga, Y Takada, H Taniguchi, M Otsuka, K Goto, K Fukao
No abstract text is available yet for this article.
November 1998: Transplantation Proceedings
Y Takada, K Fukunaga, H Taniguchi, K Yuzawa, M Otsuka, K Fukao
No abstract text is available yet for this article.
November 1998: Transplantation Proceedings
R Linke, M Diefenbeck, R Friedrich, D Seehofer, C Hammer
The main targets of xenogeneic rejection mechanisms are the endothelial cells of the graft. Their activation and the consequent alteration of the organ's microcirculation lead to the destruction of the xenograft. Microhemodynamic changes occurring during this process are still poorly characterized. The aim of this study was to analyze the microcirculation during xenogeneic ex vivo hemoperfusion of rat livers and to monitor the impact of treatment strategies using intravital fluorescence microscopy. In contrast to the isogeneic control group, blood flow almost completely stopped within the first minutes of xenoperfusion...
1998: Transplant International: Official Journal of the European Society for Organ Transplantation
Y Takada, H Taniguchi, K Fukunaga, K Yuzawa, M Otsuka, T Todoroki, T Iijima, K Fukao
BACKGROUND: Prolonged warm ischemic injury in non-heart-beating donors (NHBDs) significantly affects hepatic allograft function after liver transplantation (LTx). METHODS: The effects of FK506 and the platelet activating factor antagonist E5880 on postoperative function of hepatic allografts procured from NHBDs were evaluated in porcine orthotopic LTx. In donors, livers were subjected to 90 minutes of warm ischemia and a subsequent 4-hour cold preservation. Group 1 (n = 6) was the untreated control group...
June 1998: Surgery
M C Bellamy, H F Galley, N R Webster
Transplantation is associated with an inflammatory rejection response. Graft reperfusion causes typical haemodynamic and biochemical responses. In this study we have investigated the relationship between these haemodynamic responses and changes in circulating inflammatory mediators after graft reperfusion in 10 consecutive patients undergoing orthotopic liver transplantation. After reperfusion, systemic vascular resistance index decreased (P = 0.011) and cardiac index increased (P = 0.038). These characteristic haemodynamic changes of the reperfusion syndrome were accompanied by global increases in cytokine concentrations...
September 1997: British Journal of Anaesthesia
K I Bzeizi, R Jalan, J N Plevris, P C Hayes
No abstract text is available yet for this article.
March 1997: Liver Transplantation and Surgery
S Morooka, Y Natsume
To investigate the role of PAF in tumor-associated disseminated intravascular coagulation (DIC), we have established the tumor-induced DIC model in rats and examined the effect of PAF-antagonist as compared with commonly used anti-DIC drugs. Four days after the intraperitoneal inoculation of rat ascites hepatoma AH-130, DIC-like hematological parameter changes such as decrease in platelet count, prolongation of PTT and increase in FDP were observed. In addition, serum levels of GOT and GPT were increased, indicating that liver injury was provoked...
1996: Advances in Experimental Medicine and Biology
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