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https://www.readbyqxmd.com/read/28318536/chromobacterium-violaceum-infection-in-a-horse
#1
Márcia Elisa Hammerschmitt, Veronica Machado Rolim, Gustavo Geraldo Medina Snel, Franciele Maboni Siqueira, David Driemeier, Saulo Petinatti Pavarini
Chromobacterium violaceum is an opportunistic pathogen of mammals that produces characteristic violet pigment in bacterial culture. We report pneumonia and septicaemia caused by C. violaceum in a horse. Necropsy examination was performed on a 3-year-old Quarter Horse stallion with a history of recurrent episodes of pneumonia, fever, dyspnoea and sanguineous nasal discharge. The lungs were not collapsed, but they contained dark red foci mixed with white areas, and multiple nodules of firm consistency. Within the liver and kidney there were randomly distributed, multifocal, white pinpoint lesions (0...
March 16, 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28315918/fluorrine-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-of-adult-liver-langerhans-cell-histiocytosis
#2
Hengshan Ji, Jiang Wu, Guifen Yang, Chuanjin Sun, Hong Zhu, Longjiang Zhang
OBJECTIVE: Adult liver Langerhans cell histiocytosis (LCH) is an extremely rare desease. This paper reports a 40 years old male patient who was diagnosed as liver LCH though ultrasound-guided liver biopsy. The initial Fluorrine-18- fluorodeoxyglucose positron emission tomography/ computed tomography ((18)F-FDG PET/CT) showed multiple nodular low-density lesions in liver without obvious elevated (18)F-FDG uptake. Four years later, the follow-up (18)F-FDG PET/CT showed the liver multiple lesions with slightly elevated (18)F-FDG uptake...
March 20, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28301993/outcome-of-living-donor-liver-transplant-for-hepatocellular-carcinoma-15-year-single-center-experience-in-egypt
#3
Refaat Kamel, Yaser Hatata, Karim Hosny, Ahmed Nabil, Alaa El-Deen Abd-Allah, Aaser Mostafa, Amr Abdel-Aal, Mahmoud Z Elganzoury, Osama Elmalt, Ibrahim Marwan, Adel Hosny
OBJECTIVES: Liver transplant performed for hepatocellular carcinoma must adhere to criteria for the size and number of focal hepatic lesions to lower the incidence of recurrence and achieve survival rates comparable to patients transplanted for other indications. Since the Milan criteria were established in 1996, there have been many less restrictive criteria yielding similar results. Our aim was to identify the prognostic factors for patient survival and for recurrence of hepatocellular carcinoma for patients within and beyond the Milan criteria...
March 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28298731/magnetic-resonance-imaging-of-the-cirrhotic-liver-diagnosis-of-hepatocellular-carcinoma-and-evaluation-of-response-to-treatment-part-1
#4
REVIEW
Miguel Ramalho, António P Matos, Mamdoh AlObaidy, Fernanda Velloni, Ersan Altun, Richard C Semelka
Magnetic resonance imaging (MRI) is the modern gold standard for the noninvasive evaluation of the cirrhotic liver. The combination of arterial phase hyperenhancement and delayed wash-out allows a definitive diagnosis of hepatocellular carcinoma (HCC) in patients with liver cirrhosis or chronic liver disease, without the requirement for confirmatory biopsy. That pattern is highly specific and has been endorsed in Western and Asian diagnostic guidelines. However, the sensitivity of the combination is relatively low for small HCCs...
January 2017: Radiologia Brasileira
https://www.readbyqxmd.com/read/28297784/-etiology-and-clinical-manifestations-of-hepatic-space-occupying-lesions
#5
L Y Du, H Tang
Hepatic space-occupying lesions refer to the lesions which are located in the abnormal echo area or density area of the liver parenchyma, have the appearance of nodule or mass, occupy a certain space, and may cause pressure, displacement, or invasion of adjacent liver tissue and vessels, as determined by imaging examination. Hepatic space-occupying lesions have various causes, as well as similarities and differences in clinical manifestations. An understanding of the etiology and clinical manifestations of hepatic space-occupying lesions helps with their diagnosis and differential diagnosis and the development of targeted therapeutic regimens to improve prognosis...
January 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/28296775/giant-hepatic-metastasis-in-a-patient-with-coin-like-small-cell-lung-carcinoma-incidentally-diagnosed-at-autopsy-a-case-report
#6
Decebal Fodor, Simona Gurzu, Anca Otilia Contac, Ioan Jung
RATIONALE: Encephalopathy is a rare complication of hepatic metastases. In this paper we present a case of a patient with lung cancer and metastatic-related giant hepatomegaly. PATIENT CONCERNS: A 78-year-old previously healthy male was admitted in the Emergency room in hepatic coma. DIAGNOSES: The abdominal CT scan examination revealed a huge liver filled with solid nodules. INTERVENTIONS: No interventions were performed...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28293485/a-long-term-survivor-of-metastatic-pancreatic-adenocarcinoma-free-of-recurrence-12-years-after-treatment-of-oligometastatic-disease
#7
John M Stahl, Zenta Walther, Bryan W Chang, Howard S Hochster, Kimberly L Johung
Aggressive local therapy for patients with oligometastatic pancreatic ductal adenocarcinoma (PDAC) has traditionally not been pursued due to high rates of distant progression. We describe a 62-year-old male initially presenting with resectable PDAC who underwent the Whipple procedure but developed multiple liver metastases within two months of starting adjuvant gemcitabine. Oxaliplatin was added to the regimen and complete resolution of the liver lesions resulted. He remained disease-free for five years until re-staging revealed a small lung nodule...
February 2, 2017: Curēus
https://www.readbyqxmd.com/read/28289921/genome-wide-in-vivo-rnai-screen-identifies-itih5-as-a-metastasis-suppressor-in-pancreatic-cancer
#8
Ken Sasaki, Hiroshi Kurahara, Eric D Young, Shoji Natsugoe, Asami Ijichi, Tomoo Iwakuma, Danny R Welch
The overwhelming majority of pancreatic ductal adenocarcinoma (PDAC) is not diagnosed until the cancer has metastasized, leading to an abysmal average life expectancy (3-6 months post-diagnosis). Earlier detection and more effective treatments have been hampered by inadequate understanding of the underlying molecular mechanisms controlling metastasis. We hypothesized that metastasis suppressors are involved in controlling metastasis in pancreatic cancer. Using an unbiased genome-wide shRNA screen, an shRNA library was transduced into the non-metastatic PDAC line S2-028 followed by intrasplenic injection...
March 13, 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/28287073/validation-of-a-ct-guided-intervention-robot-for-biopsy-and-radiofrequency-ablation-experimental-study-with-an-abdominal-phantom
#9
Hyung Jin Won, Namkug Kim, Guk Bae Kim, Joon Beom Seo, Hongho Kim
PURPOSE: We aimed to evaluate the accuracy of a needle-placement robot for biopsy and radiofrequency ablation on an abdominal phantom. METHODS: A master-slave robotic system has been developed that includes a needle-path planning system and a needle-inserting robot arm with computed tomography (CT) and CT fluoroscopy guidance. For evaluation of its accuracy in needle placement, a commercially available abdominal phantom (Model 057A; CIRS Inc.) was used. The liver part of the phantom contains multiple spherical simulated tumors of three different size spheres...
March 13, 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/28283014/-fungemia-and-septic-arthritis-caused-by-saprochaete-capitata-in-a-patient-with-fanconi-aplastic-anemia-a-case-report
#10
Ömür Mustafa Parkan, Mustafa Altay Atalay, Ayşe Nedret Koç, Çiğdem Pala, Gonca Aydemir, Leylagül Kaynar
Saprochaete capitata (formerly known as Blastoschizomyces capitatus, Trichosporon capitatum, Geotrichum capitatum) is a rare but emerging yeast-like fungus. It is commonly found in environmental sources and can be isolated from skin, gastrointestinal system and respiratory tract of healthy individuals as well. It mainly infects patients with hematological malignancies such as acute myeloid leukemia (AML), especially in the presence of neutropenia; and mortality rates are high in those patients. Although the data about the in vitro antifungal susceptibility are limited, it is being reported that amphotericin B and voriconazole are more effective on S...
January 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28276299/immunohistochemical-analysis-of-the-stem-cell-marker-lgr5-in-pediatric-liver-disease
#11
Zahida Khan, Anne Orr, George K Michalopoulos, Sarangarajan Ranganathan
Aims In regenerating liver, hepatic progenitor cells (HPCs) are recruited in response to injury; however, few highly specific human HPC markers exist for the hepatocyte lineage. Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5), a Wnt-associated stem cell marker, has been extensively studied in intestinal stem cells, but little is known about its expression in human liver. We hypothesized that LGR5+ HPCs are induced in the regenerative response to pediatric liver injury. Methods and results Immunohistochemistry was used to characterize LGR5 expression in pediatric liver explants (n = 36)...
January 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28272394/amigo2-upregulation-in-tumour-cells-facilitates-their-attachment-to-liver-endothelial-cells-resulting-in-liver-metastases
#12
Yusuke Kanda, Mitsuhiko Osaki, Kunishige Onuma, Ayana Sonoda, Masanobu Kobayashi, Junichi Hamada, Garth L Nicolson, Takahiro Ochiya, Futoshi Okada
Since liver metastasis is the main cause of death in cancer patients, we attempted to identify the driver gene involved. QRsP-11 fibrosarcoma cells were injected into the spleens of syngeneic mice to isolate tumour sub-populations that colonize the liver. Cells from liver metastatic nodules were established and subsequently injected intrasplenically for selection. After 12 cycles, the cell subline LV12 was obtained. Intravenous injection of LV12 cells produced more liver metastases than QRsP-11 cells, whereas the incidence of lung metastases was similar to that of QRsP-11 cells...
March 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28266898/hepatic-malignancy-in-an-infant-with-wolf-hirschhorn-syndrome
#13
Sara Rutter, Raffaella A Morotti, Steven Peterec, Patrick G Gallagher
INTRODUCTION: Wolf-Hirschhorn syndrome (WHS) is a contiguous gene syndrome involving deletions of the chromosome 4p16 region associated with growth failure, characteristic craniofacial abnormalities, cardiac defects, and seizures. CASE REPORT: This report describes a six-month-old girl with WHS with growth failure and typical craniofacial features who died of complex congenital heart disease. Genetic studies revealed a 9.8 Mb chromosome 4p-terminal deletion. At autopsy, the liver was grossly unremarkable...
March 7, 2017: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/28262519/estimation-of-observer-performance-for-reduced-radiation-dose-levels-in-ct-eliminating-reduced-dose-levels-that-are-too-low-is-the-first-step
#14
Joel G Fletcher, Lifeng Yu, Jeff L Fidler, David L Levin, David R DeLone, David M Hough, Naoki Takahashi, Sudhakar K Venkatesh, Anne-Marie G Sykes, Darin White, Rebecca M Lindell, Amy L Kotsenas, Norbert G Campeau, Vance T Lehman, Adam C Bartley, Shuai Leng, David R Holmes, Alicia Y Toledano, Rickey E Carter, Cynthia H McCollough
RATIONALE AND OBJECTIVES: This study aims to estimate observer performance for a range of dose levels for common computed tomography (CT) examinations (detection of liver metastases or pulmonary nodules, and cause of neurologic deficit) to prioritize noninferior dose levels for further analysis. MATERIALS AND METHODS: Using CT data from 131 examinations (abdominal CT, 44; chest CT, 44; head CT, 43), CT images corresponding to 4%-100% of the routine clinical dose were reconstructed with filtered back projection or iterative reconstruction...
March 2, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28258561/a-resected-case-of-two-branch-duct-type-intraductal-papillary-mucinous-neoplasms-showing-different-clinical-courses-after-a-two-year-follow-up
#15
Hideki Shibata, Nobuyuki Ohike, Tomoko Norose, Tomohide Isobe, Reika Suzuki, Hideyuki Imai, Akira Shiokawa, Masafumi Takimoto, Akihiro Tabuchi, Yuichi Takano, Eiichi Yamamura, Masatsugu Nagahama, Nobuyuki Takeyama, Kazuaki Yokomizo, Hiroki Mizukami, Jun-Ichi Tanaka, Takeshi Aoki, Masahiko Murakami
The patient was a 60-year-old man without any particular complaints, but he underwent abdominal computed tomography (CT) and magnetic resonance cholangiopancreatography (MRCP) due to a fatty liver, which revealed two similar cystic lesions regarded as branch duct-type intraductal papillary mucinous neoplasm (BD-IPMN) in the pancreatic body [BD-IPMN (b), 16 mm in size] and tail [BD-IPMN (t), 13 mm in size] without a "high-risk stigmata" or "worrisome features". He subsequently received follow-up by MRCP every 6 months...
March 3, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28258454/indeterminate-pulmonary-nodules-in-resected-liver-metastases-from-colorectal-cancer-a-comparison-of-patient-outcomes
#16
V Robertson, C P Neal, M Jones, A R Dennison, G Garcea
AIMS: Hepatic metastasectomy remains the only potentially curative treatment for colorectal liver metastases (CRLM). Some of these patients develop indeterminate pulmonary nodules (IPNs). This study aimed to compare outcomes of patients with and without IPN undergoing resection of CRLM to ascertain whether their presence is clinically significant. METHODS: Cases and controls were identified from a prospectively maintained database of CRLM resections. Patients with staging radiology demonstrating IPNs were included as cases...
March 3, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28250689/amiodarone-induced-loculated-pleural-effusion-without-pulmonary-parenchymal-involvement-a-case-report-and-literature-review
#17
Amer Hawatmeh, Mohammad Thawabi, Ashraf Jmeian, Hamid Shaaban, Fayez Shamoon
Amiodarone is an extremely effective antiarrhythmic drug that is known to cause many adverse effects such as pulmonary, thyroid, and liver toxicities. Of these, pulmonary toxicity is most serious. Pulmonary toxicity can present as interstitial pneumonitis, organizing pneumonia, pulmonary nodules and masses, and very rarely pleural effusions. We present a case of a 73-year-old male who presented with progressive exertional dyspnea, nonproductive cough, generalized fatigue, and weakness. He was found to have multiorgan toxicity secondary to long-term treatment with high doses of amiodarone...
January 2017: Journal of Natural Science, Biology, and Medicine
https://www.readbyqxmd.com/read/28250361/a-patient-with-cystic-granuloma-trichophyticum-who-required-surgical-resection
#18
Takehiko Kaneko, Michiyo Kaneko
A 62-year-old male with numerous subcutaneous nodules in the lower extremities was referred to The University of Tokyo Hospital. The patient suffered from systemic lupus erythematosus (SLE), diabetes mellitus, and persisting hepatic dysfunction, and had been treated for SLE with oral prednisolone 20 mg/day and oral cyclosporine 3 mg/kg/day. The culture of scales collected from the patient's skin surface on Sabouraud's dextrose agar medium showed features of Trichophyton rubrum. Topically applied bifonazole cream was effective for tinea corporis, but oral griseofulvin 500 mg/day was discontinued after 2-month administration because of deteriorated liver function...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28245861/liver-radiofrequency-ablation-as-emergency-treatment-for-a-ruptured-hepatocellular-carcinoma-a-case-report
#19
Alessandra Bertacco, Francesco D'Amico, Maurizio Romano, Michele Finotti, Alessandro Vitale, Umberto Cillo
BACKGROUND: Hemoperitoneum is a possible complication of hepatocellular carcinoma that may require emergency surgery as an alternative to radiological locoregional therapies. CASE PRESENTATION: We present a case report of a 78-year-old white man with alcoholic-related cirrhosis and a multifocal hepatocellular carcinoma. An abdominal computed tomography scan showed multiple and bilateral foci of bleeding from broken liver cancer. He was urgently transferred from our radiology unit to our operating room for massive hemoperitoneum...
March 1, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28240420/clinical-utility-of-multipolar-ablation-with-a-three-dimensional-simulator-system-for-patients-with-liver-cancer
#20
Masashi Hirooka, Yohei Koizumi, Yusuke Imai, Yoshiko Nakamura, Atsushi Yukimoto, Takao Watanabe, Osamu Yoshida, Yoshio Tokumoto, Masanori Abe, Yoichi Hiasa
BACKGROUND AND AIM: To confirm the efficacy of multipolar ablation with a new simulator system, 3D sim-Navigator, for patients with hepatocellular carcinoma by assessing relapse-free survival and shape of the ablation volume under clinical conditions. METHODS: All participants provided written, informed consent, and study protocols were approved by the institutional ethics committee. Twenty-seven patients with 27 nodules were treated by no-touch ablation using the new simulator system...
February 27, 2017: Journal of Gastroenterology and Hepatology
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