Baihua Wu, Xinyi Shentu, Haitao Nan, Pengcheng Guo, Shijie Hao, Jiangshan Xu, Shuncheng Shangguan, Lei Cui, Jin Cen, Qiuting Deng, Yan Wu, Chang Liu, Yumo Song, Xiumei Lin, Zhifeng Wang, Yue Yuan, Wen Ma, Ronghai Li, Yikang Li, Qiwei Qian, Wensi Du, Tingting Lai, Tao Yang, Chuanyu Liu, Xiong Ma, Ao Chen, Xun Xu, Yiwei Lai, Longqi Liu, Miguel A Esteban, Lijian Hui
Cholestatic liver injuries, characterized by regional damage around the bile ductular region, lack curative therapies and cause considerable mortality. Here we generated a high-definition spatiotemporal atlas of gene expression during cholestatic injury and repair in mice by integrating spatial enhanced resolution omics sequencing and single-cell transcriptomics. Spatiotemporal analyses revealed a key role of cholangiocyte-driven signaling correlating with the periportal damage-repair response. Cholangiocytes express genes related to recruitment and differentiation of lipid-associated macrophages, which generate feedback signals enhancing ductular reaction...
April 16, 2024: Nature Genetics