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https://www.readbyqxmd.com/read/29318554/evaluation-of-tumor-vasculature-using-a-syngeneic-tumor-model-in-wild-type-and-genetically-modified-mice
#1
Francisco Javier Rodríguez-Baena, Silvia Redondo-García, María Del Carmen Plaza-Calonge, Rubén Fernández-Rodríguez, Juan Carlos Rodríguez-Manzaneque
The relevance of tumor vasculature has been extensively recognized, and it is still the focus of numerous lines of research for basic, translational, and clinical scientists. Indeed, the knowledge of some of its regulatory mechanisms has provoked the generation of ongoing cancer therapies. Within the context of the tumor microenvironment, the information that the analysis of the vasculature provides is very valuable, and it might reveal not just its quality and the response against a specific therapy but also its close relationship with neighboring stromal and tumor players...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29286146/immune-response-associated-gene-profiling-in-japanese-melanoma-patients-using-multi-omics-analysis
#2
Yasuto Akiyama, Yoshio Kiyohara, Shusuke Yoshikawa, Masaki Otsuka, Ryota Kondou, Chizu Nonomura, Haruo Miyata, Akira Iizuka, Tadashi Ashizawa, Keiichi Ohshima, Kenichi Urakami, Takeshi Nagashima, Masatoshi Kusuhara, Takashi Sugino, Ken Yamaguchi
Project High-tech Omics-based Patient Evaluation (HOPE), including comprehensive whole-exome sequencing (WES) and gene expression profiling (GEP) using freshly resected tumor specimens, has been in progress since its implementation in 2014. Among a total of 1,685 cancer patients, 13 melanoma patients were registered in the HOPE Project and were characterized using multi-omics analyses. Among the 13 melanoma patients, 4 were deceased, and 9 were alive. The mean overall survival (OS) and relapse‑free survival (RFS) times of the melanoma patients were 16...
December 21, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29251263/4d-tracking-with-ultra-fast-silicon-detectors
#3
Hartmut F-W Sadrozinski, Abraham Seiden, Nicolò Cartiglia
The evolution of particle detectors has always pushed the technological limit in order to provide enabling technologies to researchers in all fields of science. One archetypal example is the evolution of silicon detectors, from a system with a few channels 30 years ago, to the tens of millions of independent pixels currently used to track charged particles in all major particle physics experiments. Nowadays, silicon detectors are ubiquitous not only in research laboratories but in almost every high-tech apparatus, from portable phones to hospitals...
December 18, 2017: Reports on Progress in Physics
https://www.readbyqxmd.com/read/29247417/technology-acceptance-perception-for-promotion-of-sustainable-consumption
#4
Aindrila Biswas, Mousumi Roy
Economic growth in the past decades has resulted in change in consumption pattern and emergence of tech-savvy generation with unprecedented increase in the usage of social network technology. In this paper, the technology acceptance value gap adapted from the technology acceptance model has been applied as a tool supporting social network technology usage and subsequent promotion of sustainable consumption. The data generated through the use of structured questionnaires have been analyzed using structural equation modeling...
December 15, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29233429/pharmacy-students-perceptions-of-the-usefulness-of-motivational-interviewing-and-the-use-of-mobile-health-applications-on-patient-counseling-in-the-future
#5
Justin K Owensby, Jan Kavookjian
INTRODUCTION: To explore student pharmacists' perceptions of 1) future patient counseling, 2) use of mobile health applications (mHealth apps), and 3) usefulness of motivational interviewing (MI) in patient encounters and potential app messaging. METHODS: A cross-sectional design with first and second year pharmacy students (n=315) at a multi-campus university after exposure to mHealth app and MI curricular content. A questionnaire assessed perceptions of 1) future patient counseling, 2) using apps for personal use and professional encounters, and 3) potential practicality and usefulness of MI principles/skills in apps messaging...
July 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29231701/programmable-and-shape-memorizing-information-carriers
#6
Wenbing Li, Yanju Liu, Jinsong Leng
Shape memory polymers (SMPs) are expected to play more and more important roles in space-deployable structures, smart actuators, and other high-tech areas. Nevertheless, because of the difficulties in fabrication and the programmability of temporary shape recovery, SMPs have not yet been widely applied in real fields. It is ideal to incorporate the different independent functional building blocks into a material. Herein, we designed a simple method to incorporate four functional building blocks: a neat epoxy-based shape memory (neat SMEP) resin, an SMEP composited with Fe3O4 (SMEP-Fe3O4), an SMEP composited with multiwalled carbon nanotubes, and an SMEP composited with p-aminodiphenylimide into a multicomposite, in which the four region surfaces could be programmed with different language code patterns according to a preset command by imprint lithography...
December 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29227994/low-cost-low-tech-snp-genotyping-tools-for-resource-limited-areas-plague-in-madagascar-as-a-model
#7
Cedar L Mitchell, Voahangy Andrianaivoarimanana, Rebecca E Colman, Joseph Busch, Heidie Hornstra-O'Neill, Paul S Keim, David M Wagner, Minoarisoa Rajerison, Dawn N Birdsell
BACKGROUND: Genetic analysis of pathogenic organisms is a useful tool for linking human cases together and/or to potential environmental sources. The resulting data can also provide information on evolutionary patterns within a targeted species and phenotypic traits. However, the instruments often used to generate genotyping data, such as single nucleotide polymorphisms (SNPs), can be expensive and sometimes require advanced technologies to implement. This places many genotyping tools out of reach for laboratories that do not specialize in genetic studies and/or lack the requisite financial and technological resources...
December 11, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29119824/an-innovative-health-care-delivery-model-for-children-with-medical-complexity
#8
Anne Elizabeth Glassgow, Molly A Martin, Rachel Caskey, Melishia Bansa, Michael Gerges, Mary Johnson, Monika Marko, Kenita Perry-Bell, Heather J Risser, Peter J Smith, Benjamin Van Voorhees
Children with medical complexity (CMC) account for a disproportionate share of pediatric health-care utilization and cost that is largely attributable to long hospitalizations, frequent hospital readmissions, and high use of emergency departments. In response, the Centers for Medicare and Medicaid Services Health Care Innovation Center supports the development and testing of innovative health-care payment and service delivery models. The purpose of this article is to describe the CMS-funded coordinated health care for complex kids (CHECK) program, an innovative system of health-care delivery that provides improved, comprehensive, and well-coordinated services to CMC...
September 2017: Journal of Child Health Care: for Professionals Working with Children in the Hospital and Community
https://www.readbyqxmd.com/read/29051393/4-dimensional-tracking-with-ultra-fast-silicon-detectors
#9
Hartmut Sadrozinski, Abraham Seiden, Nicolo Cartiglia
The evolution of particle detectors has always pushed the technological limit in order to provide enabling technologies to researchers in all fields of science. One archetypal example is the evolution of silicon detectors, from a system with a few channels 30 years ago, to the tens of millions of independent pixels currently used to track charged particles in all major particle physics experiments. Nowadays, silicon detectors are ubiquitous not only in research laboratories but in almost every high tech apparatus, from portable phones to hospitals...
October 20, 2017: Reports on Progress in Physics
https://www.readbyqxmd.com/read/29047452/thermal-transport-in-epitaxial-si1-xgex-alloy-nanowires-with-varying-composition-and-morphology
#10
Alexandros El Sachat, Juan S Reparaz, Jean Spiece, Maria Isabel Alonso, Alejandro R Goni, M Garriga, Pablo Oscar Vaccaro, M R Wagner, Oleg V Kolosov, Clivia M Sotomayor Torres, Francesc Alzina
We report on structural, compositional, and thermal characterization of self-assembled in-plane epitaxial Si1-xGex alloy nanowires grown by molecular beam epitaxy on Si (001) substrates. The thermal properties were studied by means of scanning thermal microscopy, while the microstructural characteristics, the spatial distribution of the elemental composition of the alloy nanowires and the sample surface were investigated by transmission electron microscopy and energy dispersive x-ray microanalysis. We provide new insights regarding the morphology of the in-plane nanostructures, their size-dependent gradient chemical composition, and the formation of a 5 nm thick wetting layer on the Si substrate surface...
October 19, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28966546/tic-treatment-goes-tech-a-review-of-tichelper-com
#11
Christine A Conelea, Brianna C M Wellen
TicHelper.com ("TicHelper") is an interactive online treatment program for youth with chronic tic disorders (CTDs) or Tourette Syndrome (TS) and their parents. It is based on Comprehensive Behavioral Intervention for Tics (CBIT), an individual, outpatient therapy protocol shown to effectively reduce tics in randomized controlled trials. The TicHelper website offers a user-friendly dashboard that is effective in making it easy to navigate through different treatment modules. Modules parallel core CBIT procedures and consist of interactive exercises, informational videos, and self-report ratings...
August 2017: Cognitive and Behavioral Practice
https://www.readbyqxmd.com/read/28946573/exploring-cognitive-support-use-and-preference-by-college-students-with-tbi-a-mixed-methods-study
#12
Jessica Brown, Karen Hux, Morgan Hey, Madeline Murphy
PURPOSE: Many college students with TBI rely on external strategies and supports to compensate for persistent memory, organization, and planning deficits that interfere with recalling and executing daily tasks. Practitioners know little, however, about the supports students with TBI choose for this purpose, the reasoning behind their choice, or preferred features of selected supports. The purpose of this study was to explore these issues. METHOD: We collected and analyzed quantitative and qualitative data from eight college students with TBI for completion of a concurrent triangulation mixed-methods design...
2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28926565/a-snp-panel-and-online-tool-for-checking-genotype-concordance-through-comparing-qr-codes
#13
Yonghong Du, Joshua S Martin, John McGee, Yuchen Yang, Eric Yi Liu, Yingrui Sun, Matthias Geihs, Xuejun Kong, Eric Lingfeng Zhou, Yun Li, Jie Huang
In the current precision medicine era, more and more samples get genotyped and sequenced. Both researchers and commercial companies expend significant time and resources to reduce the error rate. However, it has been reported that there is a sample mix-up rate of between 0.1% and 1%, not to mention the possibly higher mix-up rate during the down-stream genetic reporting processes. Even on the low end of this estimate, this translates to a significant number of mislabeled samples, especially over the projected one billion people that will be sequenced within the next decade...
2017: PloS One
https://www.readbyqxmd.com/read/28922600/ptml-model-for-proteome-mining-of-b-cell-epitopes-and-theoretical-experimental-study-of-bm86-protein-sequences-from-colima-mexico
#14
Saúl G Martínez-Arzate, Esvieta Tenorio-Borroto, Alberto Barbabosa Pliego, Héctor M Díaz-Albiter, Juan C Vázquez-Chagoyán, Humbert González-Díaz
In this work, we developed a general perturbation theory and machine learning method for data mining of proteomes to discover new B-cell epitopes useful for vaccine design. The method predicts the epitope activity εq(cqj) of one query peptide (q-peptide) under a set of experimental query conditions (cqj). The method uses as input the sequence of the q-peptide. The method also uses as input information about the sequence and epitope activity εr(crj) of a peptide of reference (r-peptide) assayed under similar experimental conditions (crj)...
October 3, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28883677/comparison-of-results-of-measurement-of-dimensions-of-the-placed-dental-implants-on-cone-beam-computed-tomography-with-dimensions-of-the-producers-of-the-implants
#15
Merisa Repesa, Amela Sofic, Selma Jakupovic, Selma Tosum, Lejla Kazazic, Almir Dervisevic
INTRODUCTION: One of the most frequently used method for scanning patients with indication for dental implantation in dentistry is cone beam computed tomography. Implantation, CBCT imaging and implant programme are inevitable when planning a successful replacement of lost teeth. CBCT offers exact information about available bone and its density, adjacent tooth roots, the place of mandibular canal and maxillary sinus and adjacent anatomical structure. AIM: The goal of this study is to estimate accuracy of measurements on CBCT images ofpatients who have implants of different producers and determine if there is any statistically significant correlation between four test groups regardless of the alloy of which implants are made...
June 2017: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/28846134/mineral-trioxide-aggregate-and-other-bioactive-endodontic-cements-an-updated-overview-part-ii-other-clinical-applications-and-complications
#16
REVIEW
M Torabinejad, M Parirokh, P M H Dummer
Mineral trioxide aggregate (MTA) is a dental material used extensively for vital pulp therapies (VPT), protecting scaffolds during regenerative endodontic procedures, apical barriers in teeth with necrotic pulps and open apices, perforation repairs as well as root canal filling and root-end filling during surgical endodontics. A number of bioactive endodontic cements (BECs) have recently been introduced to the market. Most of these materials have calcium and silicate in their compositions; however, bioactivity is a common property of these cements...
August 28, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28806490/challenges-and-resources-for-nurses-participating-in-a-hurricane-sandy-hospital-evacuation
#17
Nancy VanDevanter, Victoria H Raveis, Christine T Kovner, Meriel McCollum, Ronald Keller
PURPOSE: Weather-related disasters have increased dramatically in recent years. In 2012, severe flooding as a result of Hurricane Sandy necessitated the mid-storm patient evacuation of New York University Langone Medical Center. The purpose of this study was to explore, from the nurses' perspective, what the challenges and resources were to carrying out their responsibilities, and what the implications are for nursing education and preparation for disaster. DESIGN: This mixed-methods study included qualitative interviews with a purposive sample of nurses and an online survey of nurses who participated in the evacuation...
August 14, 2017: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/28760153/an-overview-of-forensic-drug-testing-methods-and-their-suitability-for-harm-reduction-point-of-care-services
#18
REVIEW
Lane Harper, Jeff Powell, Em M Pijl
Given the current opioid crisis around the world, harm reduction agencies are seeking to help people who use drugs to do so more safely. Many harm reduction agencies are exploring techniques to test illicit drugs to identify and, where possible, quantify their constituents allowing their users to make informed decisions. While these technologies have been used for years in Europe (Nightlife Empowerment & Well-being Implementation Project, Drug Checking Service: Good Practice Standards; Trans European Drugs Information (TEDI) Workgroup, Factsheet on Drug Checking in Europe, 2011; European Monitoring Centre for Drugs and Drug Addiction, An Inventory of On-site Pill-Testing Interventions in the EU: Fact Files, 2001), they are only now starting to be utilized in this context in North America...
July 31, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28733271/telerehabilitation-review-of-the-state-of-the-art-and-areas-of-application
#19
REVIEW
Alessandro Peretti, Francesco Amenta, Seyed Khosrow Tayebati, Giulio Nittari, Syed Sarosh Mahdi
BACKGROUND: Telemedicine applications have been increasing due to the development of new computer science technologies and of more advanced telemedical devices. Various types of telerehabilitation treatments and their relative intensities and duration have been reported. OBJECTIVE: The objective of this review is to provide a detailed overview of the rehabilitation techniques for remote sites (telerehabilitation) and their fields of application, with analysis of the benefits and the drawbacks related to use...
July 21, 2017: JMIR Rehabilitation and Assistive Technologies
https://www.readbyqxmd.com/read/28715938/the-design-of-civic-technology-factors-that-influence-public-participation-and-impact
#20
Andrew May, Tracy Ross
Civic technology needs to be better understood in terms of the factors that promote representative public participation and impact. This paper reports on a multi-methods study of a civic tech platform that enabled the public to provide feedback on public transport to the service providers. The overall aim of this research was to investigate the public's use of a leading civic tech platform, FixMyTransport. The key findings were that: an effective and easy to use civic technology platform enables broad participation; data and process complexity need to be removed; factual information can be captured in-situ with impacts, consequences and opinions added later; emotions (if important) need to be explicitly elicited; feedback to, and a 'conversation' with, the users is important for engagement, as is a feeling of being part of a community...
July 18, 2017: Ergonomics
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