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Amy M Bauer, Scott A Baldwin, Joaquin A Anguera, Patricia A Areán, David C Atkins
BACKGROUND: To inform measurement-based care, practice guidelines suggest routine symptom monitoring, often on a weekly or monthly basis. Increasingly, patient-provider contacts occur remotely (eg, by telephone and Web-based portals), and mobile health tools can now monitor depressed mood daily or more frequently. However, the reliability and utility of daily ratings are unclear. OBJECTIVE: This study aimed to examine the association between a daily depressive symptom measure and the Patient Health Questionnaire-9 (PHQ-9), the most widely adopted depression self-report measure, and compare how well these 2 assessment methods predict patient outcomes...
June 19, 2018: Journal of Medical Internet Research
Elizabeth C Fung, Mariana G R Santos, Zila M Sanchez, Pamela J Surkan
Violence among young adults is an increasing public health concern, especially in the context of nightlife, such as around nightclubs and bars. Nightlife is associated with alcohol, drugs, and increased violence, but little is known about personal and environmental factors related to physical aggression and sexual violence in nightclubs. This study aimed to determine personal and environmental risk factors for physical and sexual aggression in nightclubs in São Paulo, Brazil. Data were collected among nightclub patrons through use of a portal survey at the entrances and exits of 31 nightclubs...
June 1, 2018: Journal of Interpersonal Violence
Yusuke Kimura, Tomohide Hori, Takafumi Machimoto, Tatsuo Ito, Toshiyuki Hata, Yoshio Kadokawa, Shigeru Kato, Daiki Yasukawa, Yuki Aisu, Yuichi Takamatsu, Taku Kitano, Tsunehiro Yoshimura
BACKGROUND: Few cases of postoperative arterioportal fistula (APF) have been documented. APF after hepatectomy is a very rare surgery-related complication. CASE PRESENTATION: A 62-year-old man was diagnosed with hepatocellular carcinoma in segments 5 and 8, respectively. Anterior segmentectomy was performed as a curative surgery. Each branch of the hepatic artery, portal vein, and biliary duct for the anterior segment was ligated together as the Glissonean bundle...
June 15, 2018: Surgical Case Reports
Han-Yu Jiang, Jie Chen, Chun-Chao Xia, Li-Kun Cao, Ting Duan, Bin Song
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and a major public health problem worldwide. Hepatocarcinogenesis is a complex multistep process at molecular, cellular, and histologic levels with key alterations that can be revealed by noninvasive imaging modalities. Therefore, imaging techniques play pivotal roles in the detection, characterization, staging, surveillance, and prognosis evaluation of HCC. Currently, ultrasound is the first-line imaging modality for screening and surveillance purposes...
June 14, 2018: World Journal of Gastroenterology: WJG
Clarissa Hernandez Stephens, Kara S Orr, Anthony J Acton, Sarah A Tersey, Raghavendra G Mirmira, Robert V Considine, Sherry L Voytik-Harbin
Widespread use of pancreatic islet transplantation for treatment of type 1 diabetes (T1D) is currently limited by requirements for long-term immunosuppression, limited donor supply, and poor long-term engraftment and function. Upon isolation from their native microenvironment, islets undergo rapid apoptosis, which is further exacerbated by poor oxygen and nutrient supply following infusion into the portal vein. Identifying alternative strategies to restore critical microenvironmental cues, while maximizing islet health and function, are needed to advance this cellular therapy...
June 12, 2018: American Journal of Physiology. Endocrinology and Metabolism
G W Xu, R Xiong, H R Wu, C W Li, S B Xu, M R Xie
Objective: To evaluate the effect of the postoperative short-term quality of life between uniportal and three portal video-assisted thoracic surgery for radical lung cancer resection. Methods: The perioperative data and short-term quality of life of 120 patients received uniportal and three portal video-assisted thoracic surgery for radical lung cancer resection were analyzed from September to November 2017 at Department of Thoracic Surgery, the First Affiliated Hospital of University of Science and Technology of China...
June 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
Mohammad Uzzal Hossain, Taimur Md Omar, Iftekhar Alam, Keshob Chandra Das, A K M Mohiuddin, Chaman Ara Keya, Md Salimullah
The bacterial species Campylobacter jejuni RM1221 (CjR) is the primary cause of campylobacteriosis which poses a global threat for human health. Over the years the efficacy of antibiotic treatment is becoming more fruitless due to the development of multiple drug resistant strains. Therefore, identification of new drug targets is a valuable tool for the development of new treatments for affected patients and can be obtained by targeting essential protein(s) of CjR. We conducted this in silico study in order to identify therapeutic targets by subtractive CjR proteome analysis...
2018: PloS One
E A Bayliss, H A Tabano, T M Gill, K Anzuoni, M Tai-Seale, H G Allore, D A Ganz, S Dublin, A L Gruber-Baldini, A L Adams, K M Mazor
Context: Patient reported outcomes (PROs) are one means of systematically gathering meaningful subjective information for patient care, population health, and patient centered outcomes research. However, optimal data management for effective PRO applications is unclear. Case description: Delivery systems associated with the Health Care Systems Research Network (HCSRN) have implemented PRO data collection as part of the Medicare annual Health Risk Assessment (HRA)...
May 10, 2018: EGEMS
Patricia Franklin, Kate Chenok, Danielle Lavalee, Rebecca Love, Liz Paxton, Courtney Segal, Erin Holve
Background: Web-based collection of patient-reported outcome measures (PROMs) in clinical practice is expanding rapidly as electronic health records include web portals for patients to report standardized assessments of their symptoms. As the value of PROMs in patient care expands, a framework to guide the implementation planning, collection, and use of PROs to serve multiple goals and stakeholders is needed. Methods: We identified diverse clinical, quality, and research settings where PROMs have been successfully integrated into care and routinely collected and analyzed drivers of successful implementation...
September 4, 2017: EGEMS
Paolo Zanaboni, Patrice Ngangue, Gisele Irène Claudine Mbemba, Thomas Roger Schopf, Trine Strand Bergmo, Marie-Pierre Gagnon
BACKGROUND: Digital health can empower citizens to manage their health and address health care system problems including poor access, uncoordinated care and increasing costs. Digital health interventions are typically complex interventions. Therefore, evaluations present methodological challenges. OBJECTIVE: The objective of this study was to provide a systematic overview of the methods used to evaluate the effects of internet-based digital health interventions for citizens...
June 7, 2018: Journal of Medical Internet Research
Diana Barger, Olivier Leleux, Valérie Conte, Vincent Sapparrart, Marie Gapillout, Isabelle Crespel, Marie Erramouspe, Sandrine Delveaux, Francois Dabis, Fabrice Bonnet
BACKGROUND: Effective antiretroviral therapy has greatly reduced HIV-related morbidity and mortality, dramatically changing the demographics of the population of people living with HIV. The majority of people living with HIV in France are well cared for insofar as their HIV infection is concerned but remain at risk for age-associated comorbidities. Their long-term, potentially complex, and growing care needs make the routine, longitudinal assessment of health-related quality of life and other patient-reported outcomes of relevance in the current treatment era...
June 7, 2018: JMIR Research Protocols
Isabelle M Sanchez, Lindsey Shankle, Marilyn T Wan, Ladan Afifi, Jashin J Wu, Frank Doris, Alisha Bridges, Marc Boas, Brian Lafoy, Sarah Truman, Ana-Maria Orbai, Junko Takeshita, Joel M Gelfand, April W Armstrong, Michael P Siegel, Wilson Liao
INTRODUCTION: To design and implement a novel cloud-based digital platform that allows psoriatic patients and researchers to engage in the research process. METHODS: Citizen Pscientist (CP) was created by the National Psoriasis Foundation (NPF) to support and educate the global psoriatic disease community, where patients and researchers have the ability to analyze data. Psoriatic patients were invited to enroll in CP and contribute health data to a cloud database by responding to a 59-question online survey...
June 6, 2018: Dermatology and Therapy
José Carlos Noronha, João Pedro Oliveira
All-inside anterior cruciate ligament reconstruction passed through a series of modifications over the past 2 decades, maintaining 2 common factors: half tunnels in both the femur and tibia and introduction of the graft into the knee through an arthroscopic portal. One of the disadvantages noted with this technique is the excessive cost of the instrumentation needed to perform it and its economic impact on the health care system. We describe a modification of the original technique, both maintaining the cortical bone in an intact state and avoiding the retrograde drill aiming device...
April 2018: Arthroscopy Techniques
Scott Christley, Walter Scarborough, Eddie Salinas, William H Rounds, Inimary T Toby, John M Fonner, Mikhail K Levin, Min Kim, Stephen A Mock, Christopher Jordan, Jared Ostmeyer, Adam Buntzman, Florian Rubelt, Marco L Davila, Nancy L Monson, Richard H Scheuermann, Lindsay G Cowell
Background: Recent technological advances in immune repertoire sequencing have created tremendous potential for advancing our understanding of adaptive immune response dynamics in various states of health and disease. Immune repertoire sequencing produces large, highly complex data sets, however, which require specialized methods and software tools for their effective analysis and interpretation. Results: VDJServer is a cloud-based analysis portal for immune repertoire sequence data that provide access to a suite of tools for a complete analysis workflow, including modules for preprocessing and quality control of sequence reads, V(D)J gene segment assignment, repertoire characterization, and repertoire comparison...
2018: Frontiers in Immunology
Rui Zhang, Zhi-Jun Zhu, Li-Ying Sun
OBJECTIVES: This study aimed to investigate the outcomes of adult liver transplant procedures using grafts from pediatric donors after circulatory death. MATERIALS AND METHODS: We retrospectively analyzed the data of 19 pediatric-to-adult liver transplant procedures from July 2013 to May 2016 in our hospital. Nineteen adult liver transplant procedures were performed using livers from pediatric donors after circulatory death. RESULTS: We performed 18 orthotopic and 1 piggyback liver transplant procedure...
June 1, 2018: Experimental and Clinical Transplantation
Steven S Coughlin, Vahé Heboyan, Lufei Young, Gianluca De Leo, Thad Wilkins
Background: There has been increasing interest in the use of web portals by patients with type 2 diabetes mellitus (T2DM). Studies of web portal use by patients with pre-diabetes have not been reported. To plan studies of web portal use by adult clinic patients seen for pre-diabetes and T2DM at an academic medical center, we examined characteristics of those who had or had not registered for a web portal. Methods: Electronic records were reviewed to identify web portal registration by patients treated for pre-diabetes or T2DM by age, sex, race and ethnicity...
May 2018: Journal of hospital management and health policy
Ingrid Toews, Aneesh Thomas George, John V Peter, Richard Kirubakaran, Luís Eduardo S Fontes, Jabez Paul Barnabas Ezekiel, Joerg J Meerpohl
BACKGROUND: Upper gastrointestinal (GI) bleeding due to stress ulcers contributes to increased morbidity and mortality in people admitted to intensive care units (ICUs). Stress ulceration refers to GI mucosal injury related to the stress of being critically ill. ICU patients with major bleeding as a result of stress ulceration might have mortality rates approaching 48.5% to 65%. However, the incidence of stress-induced GI bleeding in ICUs has decreased, and not all critically ill patients need prophylaxis...
June 4, 2018: Cochrane Database of Systematic Reviews
Tim Donovan, Lambert M Felix, James D Chalmers, Stephen J Milan, Alexander G Mathioudakis, Sally Spencer
BACKGROUND: Bronchiectasis is a chronic airway disease characterised by a destructive cycle of recurrent airway infection, inflammation and tissue damage. Antibiotics are a main treatment for bronchiectasis. The aim of continuous therapy with prophylactic antibiotics is to suppress bacterial load, but bacteria may become resistant to the antibiotic, leading to a loss of effectiveness. On the other hand, intermittent prophylactic antibiotics, given over a predefined duration and interval, may reduce antibiotic selection pressure and reduce or prevent the development of resistance...
June 3, 2018: Cochrane Database of Systematic Reviews
Guo-Qiang Zhang, Licong Cui, Remo Mueller, Shiqiang Tao, Matthew Kim, Michael Rueschman, Sara Mariani, Daniel Mobley, Susan Redline
Objective: The gold standard for diagnosing sleep disorders is polysomnography, which generates extensive data about biophysical changes occurring during sleep. We developed the National Sleep Research Resource (NSRR), a comprehensive system for sharing sleep data. The NSRR embodies elements of a data commons aimed at accelerating research to address critical questions about the impact of sleep disorders on important health outcomes. Approach: We used a metadata-guided approach, with a set of common sleep-specific terms enforcing uniform semantic interpretation of data elements across three main components: (1) annotated datasets; (2) user interfaces for accessing data; and (3) computational tools for the analysis of polysomnography recordings...
May 31, 2018: Journal of the American Medical Informatics Association: JAMIA
Lenka Barreto, Jae Hung Jung, Ameera Abdelrahim, Munir Ahmed, Guy P C Dawkins, Marcin Kazmierski
BACKGROUND: Urolithiasis is a condition where crystalline mineral deposits (stones) form within the urinary tract. Urinary stones can be located in any part of the urinary tract. Affected children may present with abdominal pain, blood in the urine or signs of infection. Radiological evaluation is used to confirm the diagnosis, to assess the size of the stone, its location, and the degree of possible urinary obstruction. OBJECTIVES: To assess the effects of different medical and surgical interventions in the treatment of urinary tract stones of the kidney or ureter in children...
June 2, 2018: Cochrane Database of Systematic Reviews
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