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https://www.readbyqxmd.com/read/29158927/liver-metastases-in-pancreatic-acinar-cell-carcinoma-treated-with-selective-internal-radiation-therapy-with-y-90-resin-microspheres
#1
Felipe Nasser, Joaquim Maurício Motta Leal Filho, Breno Boueri Affonso, Francisco Leonardo Galastri, Rafael Noronha Cavalcante, Diego Lima Nava Martins, Vanderlei Segatelli, Lilian Yuri Itaya Yamaga, Rene Claudio Gansl, Bernardino Tranchesi Junior, Antônio Luiz de Vasconcellos Macedo
Background: Pancreatic acinar cell carcinoma (PACC) is a rare tumor. Surgical resection is the treatment of choice when feasible, but there are no clear recommendations for patients with advanced disease. Liver-directed therapy with Y-90 selective internal radiation therapy (SIRT) has been used to treat hepatic metastases from pancreatic tumors. We describe a case of PACC liver metastases treated with SIRT. Case Report: 59-year-old man was admitted with an infiltrative, solid lesion in pancreatic tail diagnosed as PACC...
2017: Case Reports in Hepatology
https://www.readbyqxmd.com/read/29138744/multiple-myeloma-in-an-amur-tiger-panthera-tigris-altaica
#2
Alison M Lee, Naomi Guppy, John Bainbridge, Hanne Jahns
The Amur tiger (Panthera tigris altaica) is an endangered tiger subspecies. An adult zoo-bred female was found collapsed, and died despite supportive treatment. Hematology and biochemistry showed pancytopenia and hyperglobulinemia, and serum protein electrophoresis revealed a monoclonal band in the β-globulin region. Necropsy demonstrated hemoabdomen, multifocal lytic bone marrow lesions, splenomegaly, and hemorrhagic hepatic nodules, with left medial lobe rupture. There were mutifocal hemorrhages in the subcutis, lung, epicardium, and intestinal mucosa...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/29104783/expression-levels-of-the-uridine-cytidine-kinase-like-1-protein-as-a-novel-prognostic-factor-for-hepatitis-c-virus-associated-hepatocellular-carcinomas
#3
A Buivydiene, V Liakina, J Valantinas, J Norkuniene, E Mockiene, S Jokubauskiene, R Smaliukiene, L Jancoriene, L Kovalevska, E Kashuba
The expression levels of the two novel oncoproteins uridine-cytidine kinase like-1 (UCKL-1) and mitochondrial ribosomal protein S18-2 (MRPS18-2) were assessed in samples of hepatitis C virus (HCV)-associated hepatocellular carcinoma (HCC) using immunohistochemistry. Tissue microarray (TMA) paraffin blocks were prepared from 42 HCC tumor samples with the corresponding peri-tumor tissues and from 11 tissues of a liver with HCV-induced cirrhosis. We found that the UCKL-1 signal in the liver tissues of the peri-tumor zone in the HCC samples was stronger than that in cirrhosis (50 ± 49...
July 2017: Acta Naturae
https://www.readbyqxmd.com/read/29084013/ring-like-enhancement-of-hepatocellular-carcinoma-in-gadoxetic-acid-enhanced-multiphasic-hepatic-arterial-phase-imaging-with-differential-subsampling-with-cartesian-ordering
#4
Shintaro Ichikawa, Utaroh Motosugi, Naoki Oishi, Tatsuya Shimizu, Tetsuya Wakayama, Nobuyuki Enomoto, Masanori Matsuda, Hiroshi Onishi
OBJECTIVE: The aim of this study was to evaluate the efficacy of multiphasic hepatic arterial phase (HAP) imaging using DISCO (differential subsampling with Cartesian ordering) in increasing the confidence of diagnosis of hepatocellular carcinoma (HCC). MATERIALS AND METHODS: This retrospective study was approved by the institutional review board, and the requirement for informed patient consent was waived. Consecutive patients (from 2 study periods) with malignant liver nodules were examined by gadoxetic acid-enhanced magnetic resonance imaging using either multiphasic (6 phases; n = 135) or single (n = 230) HAP imaging, which revealed 519 liver nodules other than benign ones (HCC, 497; cholangiocarcinoma, 11; metastases, 10; and malignant lymphoma, 1)...
October 27, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/29067511/safety-and-efficacy-of-transarterial-radioembolization-combined-with-chemoembolization-for-bilobar-hepatocellular-carcinoma-a-single-center-retrospective-study
#5
Joon Ho Kwon, Gyoung Min Kim, Kichang Han, Jong Yun Won, Man Deuk Kim, Do Yun Lee, Junhyung Lee, Woosun Choi, Yong Seek Kim, Do Young Kim, Kwang-Hyub Han
BACKGROUND: Radioembolization induced liver disease (REILD) is a possible sequela of transarterial radioembolization (TARE), particularly in cases of whole-liver treatment. To mitigate this problem, the safety and efficacy of combined transarterial chemoembolization (TACE) and TARE were evaluated for patients with bilobar hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Nineteen patients (mean age 60 years; range 27-82 years) treated for HCC between June 2012 and September 2014 were included in the analysis...
October 24, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29050542/hepatic-mastocytosis-in-japanese-black-cattle
#6
Susumu Ohfuji
In 5 Japanese Black steers (2-2.4 years old) that originated from 5 different feedlots, the livers were found at slaughter to have multiple nodular or cordlike lesions (5 steers) and an extensive fibrotic area (1 steer). Microscopic changes included extensive fibroplasia in the portal tracts and chronic proliferative endophlebitis-like lesions confined to the portal vein branches. Fibroplasia was much more prominent in the macroscopic fibrotic lesion of 1 steer. Portal vein branches presented irregular variciform dilation of the vascular lumen and fibroplastic changes in the subendothelial areas that showed occasional hemorrhage and were simultaneously infiltrated with large numbers of mast cells and moderate to large numbers of eosinophils...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/29040990/non-hypervascular-hypointense-hepatic-nodules-during-the-hepatobiliary-phase-of-gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic-acid-enhanced-mri-as-a-risk-factor-of-intrahepatic-distant-recurrence-after-radiofrequency-ablation-of-hepatocellular-carcinoma
#7
Takayuki Iwamoto, Yasuharu Imai, Takumi Igura, Sachiyo Kogita, Yoshiyuki Sawai, Kazuto Fukuda, Yoshitaka Yamaguchi, Yasushi Matsumoto, Masanori Nakahara, Osakuni Morimoto, Hiroshi Ohashi, Norihiko Fujita, Masatoshi Kudo, Tetsuo Takehara
BACKGROUND: Non-hypervascular hypointense hepatic nodules during the hepatobiliary phase of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI have been reported to be associated with intrahepatic distant recurrence (IDR) after hepatectomy or radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC). IDR is categorized into hypervascular transformation of non-hypervascular hypointense hepatic nodules and new intrahepatic recurrence. The aim of this study was to evaluate the relationship between non-hypervascular hypointense hepatic nodules on Gd-EOB-DTPA-enhanced MRI and IDR after RFA, focusing on new intrahepatic recurrence...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/29034239/hepatoid-adenocarcinoma-of-the-stomach-a-challenging-diagnostic-and-therapeutic-disease-through-a-case-report-and-review-of-the-literature
#8
Najla Fakhruddin, Hisham F Bahmad, Tarek Aridi, Yara Yammine, Rami Mahfouz, Fouad Boulos, Ahmad Awada, Fadi Farhat
Hepatoid adenocarcinoma of the stomach (HAS) is a rare aggressive tumor with hepatocellular differentiation. HAS often produces alpha fetoprotein (AFP) and metastasizes to the lymph nodes and the liver. Molecular studies revealed Her2 amplification and overexpression, association with p53 mutations, but no association with KRAS mutations. EGFR and BRAF mutations have not yet been evaluated in hepatoid carcinoma of the stomach so far. Hereby, we present a case of a 41-year-old female patient with HAS with high AFP level and liver metastases...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29033416/progression-of-hepatic-hypovascular-nodules-with-hypointensity-in-the-hepatobiliary-phase-of-gd-eob-dtpa-enhanced-mri-in-hepatocellular-carcinoma-cases
#9
Tsukasa Saitoh, Shuichi Sato, Tomotaka Yazaki, Hiroshi Tobita, Tatsuya Miyake, Shunji Ishihara, Takashi Katsube, Hajime Kitagaki, Yoshikazu Kinoshita
Purpose We investigated the possible factors for predicting the future progression to hepatocellular carcinoma (HCC) from hypovascular nodules detected in the hepatobiliary phase of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging (Gd-EOB-DTPA-MRI). Material and Methods A total of 91 hypovascular nodules detected by Gd-EOB-DTPA-MRI in 28 patients without any past history of treatment for HCC were retrospectively examined. The nodules were categorized into those with and without HCC progression, then comparisons were made to identify any factors possibly related to a progression to HCC in each case...
October 16, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29016305/real-time-polymerase-chain-reaction-assay-on-bronchoalveolar-lavage-an-alternative-method-for-diagnosing-chronic-pulmonary-schistosomiasis
#10
Federico Gobbi, Fabio Formenti, Francesca Perandin, Dora Buonfrate, Andrea Angheben, Simona Paiano, Zeno Bisoffi
Schistosomiasis causes mainly hepatic and genitourinary damage. Although lung nodules have been commonly described in acute phase, they are presumably underdiagnosed in chronic schistosomiasis. We previously reported a series of patients with chronic pulmonary schistosomiasis confirmed by the histological examination of the lung biopsies. In the present work, we retrospectively tested an in-house real-time polymerase chain reaction for Schistosoma (currently validated for diagnosis on stool and on urine) in the bronchoalveolar lavage (BAL) of a couple of those patients, and both resulted positive...
October 9, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28987693/association-between-non-hypervascular-hypointense-nodules-on-gadoxetic-acid-enhanced-mri-and-liver-stiffness-or-hepatocellular-carcinoma
#11
Jeong Ah Hwang, Tae Wook Kang, Young Kon Kim, Seong Hyun Kim, Yong Han Paik, Sang Yun Ha, Seonwoo Kim
PURPOSE: To assess the association between non-hypervascular hypointense nodules (NHHNs) on gadoxetic acid-enhanced magnetic resonance imaging (MRI) and liver stiffness (LS) in patients with chronic liver disease, and analyzed their progression to overt hepatocellular carcinoma (HCC). METHODS: Between August 2012 and March 2016, a total of 714 consecutive patients who had undergone transient elastography for LS measurement and gadoxetic acid-enhanced MRI were investigated...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28985870/polymeric-micelles-loaded-with-1-2-diaminocyclohexane-platinum-ii-against-colorectal-cancer
#12
Takako Nirei, Soichiro Ishihara, Toshiaki Tanaka, Tomomichi Kiyomatsu, Kazushige Kawai, Keisuke Hata, Hioaki Nozawa, Toshiaki Watanabe
BACKGROUND: We investigated the potential of nanomedicine in loading the oxaliplatin parent complex (1,2-diaminocyclohexane)platinum(II)-loaded polymeric micelles (DACHPt/m) against multiple liver metastases from colon cancer in a mouse model. MATERIALS AND METHODS: The efficacy of DACHPt/m or oxaliplatin (on days 14 and 21 after inoculation of tumor cells) was evaluated in a mouse model of liver metastasis for murine colon adenocarcinoma C26 cells. In vivo antitumor effects were evaluated by recording the number of liver metastases and weights of metastatic livers after treatment (day 28)...
October 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28970735/arterioportal-shunt-incidental-to-treatment-with-oxaliplatin-that-mimics-recurrent-gastric-cancer
#13
Hong-Beum Kim, Sang-Gon Park
Arterioportal shunt (APS) is an organic communication between the hepatic arterial system and the portal venous system. The APS is one of the major causes of transient hepatic attenuation differences on dynamic computed tomography (CT) or magnetic resonance imaging (MRI). This condition is usually associated with trauma, liver cirrhosis, and malignancies of the liver. However, there has been no report about oxaliplatin-induced APS. A 41-year-old male was diagnosed with Stage IIIB gastric cancer. The patient initially underwent neoadjuvant chemotherapy with capecitabine and oxaliplatin After 3 cycles of therapy, the mass had markedly decreased, and a total gastrectomy with splenectomy was performed...
September 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28917218/erythema-elevatum-diutinum-in-crohn-s-disease-associated-spondyloarthritis-a-rare-vasculitis-an-unusual-association
#14
Maria João Gonçalves, Vasco C Romão, Luís Soares-de-Almeida, Helena Canhão, José Carlos Romeu, Heinz Kutzner, José Alberto Pereira-da-Silva
Erythema elevatum diutinum is a rare neutrophilic dermatoses with vasculitis, which presents as persistent, symmetrical, purple or brownish papules and nodules, mainly in the extensor surface of the limbs. We describe a case of erythema elevatum diutinum and polyarthritis as initial manifestations of Crohn's disease associated spondyloarthritis. A 51-year-old man, from São Tomé e Príncipe, with previous history of treated tuberculosis and chronic hepatitis B infection, was admitted due to 4 months history of polyarthritis, hyperpigmented papules on the extensor surfaces, occasional episodes of bloody mucous diarrhea and significant weight loss...
September 14, 2017: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/28916905/small-cholangiolocellular-carcinoma-that-was-difficult-to-distinguish-from-cholangiocellular-carcinoma-a-case-report
#15
Norihiro Ishii, Kenichiro Araki, Takahiro Yamanaka, Tadashi Handa, Mariko Tsukagoshi, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Shinichi Aishima, Hiroyuki Kuwano, Ken Shirabe
BACKGROUND: Cholangiolocellular carcinoma (CoCC) is thought to be derived from hepatic progenitor cells. Because of its origin, CoCC has diverse clinicopathological and imaging findings. Here, we report a case of small CoCC that was difficult to diagnose preoperatively. CASE PRESENTATION: A 62-year-old woman was confirmed with a small liver nodule in the left lobe 2 years after a sustained virological response of hepatitis C virus. The size of the nodule was 11...
September 15, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28915576/hepatic-b-cell-leukemia-3-suppresses-chemically-induced-hepatocarcinogenesis-in-mice-through-altered-mapk-and-nf-%C3%AE%C2%BAb-activation
#16
Nadine Gehrke, Marcus A Wörns, Amrit Mann, Yvonne Huber, Nadine Hoevelmeyer, Thomas Longerich, Ari Waisman, Peter R Galle, Jörn M Schattenberg
The transcriptional nuclear factor kappa B (NF-κB)-coactivator B cell leukemia-3 (Bcl-3) is a molecular regulator of cell death and proliferation. Bcl-3 has been shown to be widely expressed in different cancer types including hepatocellular carcinoma (HCC). Its influence on hepatocarcinogenesis is still undetermined. To examine the role of Bcl-3 in hepatocarcinogenesis mice with hepatocyte-specific overexpression of Bcl-3 (Bcl-3(Hep)) were exposed to diethylnitrosamine (DEN) and phenobarbital (PB). Hepatic Bcl-3 overexpression attenuated DEN/PB-induced hepatocarcinogenesis...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28892791/in-vitro-in-silico-and-in-vivo-antitumor-activity-of-crude-methanolic-extract-of-tetilla-dactyloidea-carter-1869-on-den-induced-hcc-in-a-rat-model
#17
Gowri Shankar Krishnan, Vidhya Rajagopal, Sophy Renilda Antony Joseph, Divya Sebastian, Ignacimuthu Savarimuthu, Karthick Raja Namasivayam Selvaraj, Albin Fleming Thobias
Tetilla dactyloidea (Carter, 1869) is a marine sponge classified under Demospongia and recent studies have demonstrated that active constituents of Demospongia class have exhibited several potential medical applications. However, no preliminary pharmacological studies have been reported so far. The present investigation was carried out to evaluate the zoo-chemical status, antioxidant potential and anticancer activity of Crude Methanolic Extract of Tetilla dactyloidea (CMETD). Hepatocellular Carcinoma (HCC) was induced in the liver of male Sprague Dawley (SD) rats by treating with diethylnitrosamine (DEN)...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28884440/disappearance-of-multiple-hyperechoic-liver-nodules-in-sporadic-porphyria-cutanea-tarda-after-treatment-with-ledipasvir-sofosbuvir-for-hepatitis-c
#18
Kazuhide Takata, Satoshi Shakado, Keiko Sakamoto, Hiromi Fukuda, Ryo Yamauchi, Sho Fukuda, Hideo Kunimoto, Kaoru Umeda, Takashi Tanaka, Keiji Yokoyama, Daisuke Morihara, Yasuaki Takeyama, Makoto Irie, Shotaro Sakisaka
Ultrasonography in a 60-year-old man with chronic hepatitis C (CHC) demonstrated multiple hyperechoic nodules. Radiological investigations did not reveal any signs of malignancy. However, magnetic resonance chemical shift imaging showed multiple focal fatty changes in the liver. Urinary levels of uroporphyrin and coproporphyrin were elevated, and we made a diagnosis of porphyria cutanea tarda. Direct-acting antivirals, ledipasvir/sofosbuvir, were initiated for CHC, which led to sustained viral response, resolution of the liver nodules, and normalization of urinary porphyrin...
October 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28881643/critical-analysis-of-the-major-and-ancillary-imaging-features-of-li-rads-on-127-proven-hccs-evaluated-with-functional-and-morphological-mri-lights-and-shadows
#19
Vincenza Granata, Roberta Fusco, Antonio Avallone, Francesco Filice, Fabiana Tatangelo, Mauro Piccirillo, Roberto Grassi, Francesco Izzo, Antonella Petrillo
PURPOSE: To report a critical analysis of major and ancillary MR imaging features in assessment of HCC. METHODS: Retrospectively we evaluated 70 cirrhotic patients with 173 nodules, which were subjected to MR study at 0 time (MR0), after 3 (MR3) and 6 months (MR6) using two different contrast media. EOB-GD-DTPA was injected at MR0 and MR6, while Gd-BT-DO3A at MR3. Three expert hepatic radiologists reviewed all images, recording, according to LI-RADS, the size, the presence and quality of arterial-phase hyperenhancement, washout and capsule appearance, threshold growth...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28878857/unusual-soft-tissue-uptake-of-f-18-sodium-fluoride-in-three-patients-undergoing-f-18-naf-pet-ct-bone-scans-for-prostate-cancer
#20
Andrew S Hawkins, Brandon A Howard
Three males aged 71 to 80 years with known stage IV metastatic prostate cancer underwent F-18 sodium fluoride (NaF) PET/CT to assess osseous metastatic disease burden and stability. In addition to F-18 NaF avid known osseous metastases, each patient also exhibited increased F-18 NaF activity in soft tissues. The first patient exhibited multiple F-18 NaF avid enlarged retroperitoneal and pelvic lymph nodes on consecutive PET/CT scans. The second patient demonstrated an F-18 NaF avid thyroid nodule on consecutive PET/CT scans...
September 2017: Nuclear Medicine and Molecular Imaging
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