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sleep deprivation, nk cells

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https://www.readbyqxmd.com/read/26157345/sleep-deprivation-induces-changes-in-immunity-in-trichinella-spiralis-infected-rats
#1
Elizabeth G Ibarra-Coronado, Javier Velazquéz-Moctezuma, Daniel Diaz, Luis Enrique Becerril-Villanueva, Lenin Pavón, Jorge Morales-Montor
Sleep is considered an important predictor of immunity. A lack of sleep may reduce immunity, which increases susceptibility to any type of infection. Moreover, sleep deprivation in humans produces changes in both, the percent of circulating immune cells (T cells and NK cells) and cytokine levels (IL-1, IFNγ, TNΦ-αα, IL-6 and IL-17). The aim of our study was to investigate whether sleep deprivation produces deregulation on immune variables during the immune response generated against the helminth parasite Trichinella spiralis...
2015: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/25929826/sleep-deprivation-reduces-nk-cell-number-and-function-mediated-by-%C3%AE-adrenergic-signalling
#2
Beatriz H P De Lorenzo, Laís de Oliveira Marchioro, Carollina Ribeiro Greco, Deborah Suchecki
Reduction of sleep time triggers a stress response, leading to augmented levels of glucocorticoids and adrenaline. These hormones regulate components of the innate immune system such as natural killer (NK) and NKT cells. In the present study, we sought to investigate whether and how stress hormones could alter the population and function of NK and NKT cells of mice submitted to different lengths of paradoxical sleep deprivation (PSD, from 24 to 72 h). Results showed that 72h of PSD decreased not only NK and NKT cell counts, but also their cytotoxic activity against B16F10 melanoma cells in vitro...
July 2015: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/25582807/sleep-disruption-and-its-effect-on-lymphocyte-redeployment-following-an-acute-bout-of-exercise
#3
Lesley A Ingram, Richard J Simpson, Eva Malone, Geraint D Florida-James
Sleep disruption and deprivation are common in contemporary society and have been linked with poor health, decreased job performance and increased life-stress. The rapid redeployment of lymphocytes between the blood and tissues is an archetypal feature of the acute stress response, but it is not known if short-term perturbations in sleep architecture affect lymphocyte redeployment. We examined the effects of a disrupted night sleep on the exercise-induced redeployment of lymphocytes and their subtypes. 10 healthy male cyclists performed 1h of cycling at a fixed power output on an indoor cycle ergometer, following a night of undisrupted sleep (US) or a night of disrupted sleep (DS)...
July 2015: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/23635771/resilience-of-the-immune-system-in-healthy-young-students-to-30-hour-sleep-deprivation-with-psychological-stress
#4
RANDOMIZED CONTROLLED TRIAL
Pini Matzner, Ofir Hazut, Reut Naim, Lee Shaashua, Liat Sorski, Ben Levi, Avi Sadeh, Ilan Wald, Yair Bar-Haim, Shamgar Ben-Eliyahu
OBJECTIVE: Young adults often encounter sleep deprivation and stressful events. Both have been separately reported to modulate immunity, and occasionally they occur simultaneously. We assessed the combined effects of these conditions on immune competence in healthy students. METHODS: Twenty-three participants (mean age 24 years; SD 1.86; 14 females) were exposed to 30 h of sleep deprivation during which they conducted physiological, social and cognitive tasks. The control group consisted of 18 participants (mean age 23...
2013: Neuroimmunomodulation
https://www.readbyqxmd.com/read/22947657/whole-blood-genome-wide-gene-expression-profile-in-males-after-prolonged-wakefulness-and-sleep-recovery
#5
R Pellegrino, D Y Sunaga, C Guindalini, R C S Martins, D R Mazzotti, Z Wei, Z J Daye, M L Andersen, S Tufik
Although the specific functions of sleep have not been completely elucidated, the literature has suggested that sleep is essential for proper homeostasis. Sleep loss is associated with changes in behavioral, neurochemical, cellular, and metabolic function as well as impaired immune response. Using high-resolution microarrays we evaluated the gene expression profiles of healthy male volunteers who underwent 60 h of prolonged wakefulness (PW) followed by 12 h of sleep recovery (SR). Peripheral whole blood was collected at 8 am in the morning before the initiation of PW (Baseline), after the second night of PW, and one night after SR...
November 1, 2012: Physiological Genomics
https://www.readbyqxmd.com/read/21496482/short-natural-sleep-is-associated-with-higher-t-cell-and-lower-nk-cell-activities
#6
Elinor Fondell, John Axelsson, Kristina Franck, Alexander Ploner, Mats Lekander, Katarina Bälter, Hans Gaines
Short sleep duration increases the risk of several diseases, possibly involving compromised immune function. However, most previous studies are based on experimentally induced sleep deprivation, and only a few have studied natural variations in sleep duration. Thus our aim was to study how natural variations in sleep duration affect immune function. In total, 36 healthy men and women, aged 20-54, donated blood; 29 on three consecutive mornings, and seven on one morning. Each morning, participants self-reported sleep duration the night prior to blood draw...
October 2011: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/21446353/position-statement-part-two-maintaining-immune-health
#7
REVIEW
Neil P Walsh, Michael Gleeson, David B Pyne, David C Nieman, Firdaus S Dhabhar, Roy J Shephard, Samuel J Oliver, Stéphane Bermon, Alma Kajeniene
The physical training undertaken by athletes is one of a set of lifestyle or behavioural factors that can influence immune function, health and ultimately exercise performance. Others factors including potential exposure to pathogens, health status, lifestyle behaviours, sleep and recovery, nutrition and psychosocial issues, need to be considered alongside the physical demands of an athlete's training programme. The general consensus on managing training to maintain immune health is to start with a programme of low to moderate volume and intensity; employ a gradual and periodised increase in training volumes and loads; add variety to limit training monotony and stress; avoid excessively heavy training loads that could lead to exhaustion, illness or injury; include non-specific cross-training to offset staleness; ensure sufficient rest and recovery; and instigate a testing programme for identifying signs of performance deterioration and manifestations of physical stress...
2011: Exercise Immunology Review
https://www.readbyqxmd.com/read/19240794/sleep-restriction-increases-the-risk-of-developing-cardiovascular-diseases-by-augmenting-proinflammatory-responses-through-il-17-and-crp
#8
Wessel M A van Leeuwen, Maili Lehto, Piia Karisola, Harri Lindholm, Ritva Luukkonen, Mikael Sallinen, Mikko Härmä, Tarja Porkka-Heiskanen, Harri Alenius
BACKGROUND: Sleep restriction, leading to deprivation of sleep, is common in modern 24-h societies and is associated with the development of health problems including cardiovascular diseases. Our objective was to investigate the immunological effects of prolonged sleep restriction and subsequent recovery sleep, by simulating a working week and following recovery weekend in a laboratory environment. METHODS AND FINDINGS: After 2 baseline nights of 8 hours time in bed (TIB), 13 healthy young men had only 4 hours TIB per night for 5 nights, followed by 2 recovery nights with 8 hours TIB...
2009: PloS One
https://www.readbyqxmd.com/read/17401058/immune-function-declines-with-unemployment-and-recovers-after-stressor-termination
#9
Frances Cohen, Margaret E Kemeny, Leonard S Zegans, Paul Johnson, Kathleen A Kearney, Daniel P Stites
OBJECTIVE: To examine the effect of unemployment on natural killer cell cytotoxicity (NKCC) and, in a subsample of persons who become re-employed, to determine if, after termination of the stressor, immune values recover to levels similar to matched controls. METHODS: One hundred unemployed and 100 matched employed healthy men and women, aged 29 to 45 years, were followed for 4 months with monthly blood samples taken to measure NKCC, the ability of NK cells to kill target cells...
April 2007: Psychosomatic Medicine
https://www.readbyqxmd.com/read/17029702/poor-sleep-the-night-before-an-experimental-stressor-predicts-reduced-nk-cell-mobilization-and-slowed-recovery-in-healthy-women
#10
COMPARATIVE STUDY
Caroline E Wright, Joel Erblich, Heiddis B Valdimarsdottir, Dana H Bovbjerg
Sleep is important for health; however, poor sleep is a growing problem in many Western societies, particularly among women. Alterations in immune function following poor sleep (defined by duration and disruption) may be linked to ill health. Not yet investigated are the possible effects on stress-induced mobilization of lymphocytes. As natural killer (NK) cells are particularly responsive to acute stress, the present study examined whether sleep period duration and percentage of time awake after sleep onset (WASO) the night before a laboratory stressor would predict reduced NK cell mobilization...
March 2007: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/16859893/sleep-fatigue-and-nk-cell-activity-in-healthy-volunteers-significant-relationships-revealed-by-within-subject-analyses
#11
COMPARATIVE STUDY
Keren Shakhar, Heiddis B Valdimarsdottir, Josephine S Guevarra, Dana H Bovbjerg
Poor sleep is thought to compromise health partially through its effect on immune function. Although experimental studies have shown that sleep deprivation reduces natural killer cell activity (NKCA) within individuals, cross-sectional studies of individuals in ordinary life have often failed to find such a relationship. The current study compared cross-sectional and longitudinal approaches to explore the association between sleep and NKCA. The relationship between NKCA and fatigue was also studied since individuals who are highly fatigued due to various clinical conditions often exhibit reduced NKCA...
February 2007: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/15905625/effects-of-combined-stress-during-intense-training-on-cellular-immunity-hormones-and-respiratory-infections
#12
Danielle Gomez-Merino, Catherine Drogou, Mounir Chennaoui, Eve Tiollier, Jacques Mathieu, Charles Yannick Guezennec
OBJECTIVES: This study was designed to determine immune and hormonal changes and their relationship with the incidence of upper respiratory tract infections (URTIs) during an extremely stressful military training (3 weeks of physical conditioning followed by a 5-day combat course with energy restriction, sleep deprivation and psychological stress). METHODS: Blood samples were collected from 21 cadets (21 +/- 2 years old) before training and after the combat course for analysis of leukocyte and lymphocyte subpopulations, serum cytokines [interleukin-6 (IL-6), IL-1beta and IL-10], and hormones [catecholamines, cortisol, leptin, total insulin-like growth factor I (IGF-I), prolactin, dehydroepiandrosterone sulfate (DHEAS) and testosterone]...
2005: Neuroimmunomodulation
https://www.readbyqxmd.com/read/15249733/differential-effects-of-rapid-eye-movement-sleep-deprivation-and-immobilization-stress-on-blood-lymphocyte-subsets-in-rats
#13
Javier Velazquez-Moctezuma, Emilio Dominguez-Salazar, Edith Cortes-Barberena, Oralia Najera-Medina, Socorro Retana-Marquez, Ernesto Rodriguez-Aguilera, Anabel Jiménez-Anguiano, Leticia Cortes-Martinez, Rocio Ortiz-Muñiz
OBJECTIVES: There is growing evidence of the relationship between sleep and the immune response. Studies aimed at elucidating the function of rapid eye movement (REM) sleep have found it difficult to separate the effects due to REM sleep deprivation and the effects due to the stress produced by the deprivation procedure. It has been claimed that immobilization is the main stressor that the animals have to face during the deprivation process. In this study, we analyzed the effects of short-term (24 h) and long-term (240 h) REM sleep deprivation on the distribution of lymphocyte subsets in the peripheral blood of rats...
2004: Neuroimmunomodulation
https://www.readbyqxmd.com/read/14625399/the-neurological-significance-of-abnormal-natural-killer-cell-activity-in-chronic-toxigenic-mold-exposures
#14
REVIEW
Ebere Anyanwu, Andrew W Campbell, Joseph Jones, John E Ehiri, Akpan I Akpan
Toxigenic mold activities produce metabolites that are either broad-spectrum antibiotics or mycotoxins that are cytotoxic. Indoor environmental exposure to these toxigenic molds leads to adverse health conditions with the main outcome measure of frequent neuroimmunologic and behavioral consequences. One of the immune system disorders found in patients presenting with toxigenic mold exposure is an abnormal natural killer cell activity. This paper presents an overview of the neurological significance of abnormal natural killer cell (NKC) activity in chronic toxigenic mold exposure...
November 13, 2003: TheScientificWorldJournal
https://www.readbyqxmd.com/read/12587190/alterations-of-host-defence-system-after-sleep-deprivation-are-followed-by-impaired-mood-and-psychosocial-functioning
#15
P Heiser, B Dickhaus, C Opper, U Hemmeter, H Remschmidt, W Wesemann, J C Krieg, W Schreiber
In healthy humans, sleep deprivation (SD) has consistently been demonstrated to impair different parameters of the host defence system and of psychosocial functioning. However, the individual timing of these alterations and their possible association have remained unknown so far. We therefore investigated functional measures of the individual host defence system as well as of subjective well-being and psychosocial performance in 10 healthy male adults before and after SD, as well as after recovery sleep. In detail, we examined the number of leukocytes, granulocytes, monocytes, lymphocytes, B cells, T cells, T helper and cytotoxic T cells, natural killer (NK) cells as well as the interleukin-1 beta (IL-1 beta) release from platelets after serotonin (5-HT) stimulation...
April 2001: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/11683483/total-sleep-deprivation-induces-an-acute-and-transient-increase-in-nk-cell-activity-in-healthy-young-volunteers
#16
Y Matsumoto, K Mishima, K Satoh, T Tozawa, Y Mishima, T Shimizu, Y Hishikawa
STUDY OBJECTIVES: To investigate the effects of one night's total sleep deprivation (TSD) on NK cell activity, with rigorous control of circadian phase of sampling points as well as physical exercise level in association with sleep deprivation. DESIGN: The mean sleep onset time of each subject before starting the study was defined as his 0000 h. This study was composed of a Sleep-Sleep session (sleep times, 00:00 h - 08:00 h and 24:00 h - 32:00 h) and a Sleep-Wake session (sleep time, 00:00 h - 08:00 h) with TSD (24:00 h - 32:00 h) placed in a cross-over design with 2-week interval between each session...
November 1, 2001: Sleep
https://www.readbyqxmd.com/read/11511309/stress-induced-changes-in-skin-barrier-function-in-healthy-women
#17
M Altemus, B Rao, F S Dhabhar, W Ding, R D Granstein
Despite clear exacerbation of several skin disorders by stress, the effect of psychologic or exertional stress on human skin has not been well studied. We investigated the effect of three different stressors, psychologic interview stress, sleep deprivation, and exercise, on several dermatologic measures: transepidermal water loss, recovery of skin barrier function after tape stripping, and stratum corneum water content (skin conductance). We simultaneously measured the effects of stress on plasma levels of several stress-response hormones and cytokines, natural killer cell activity, and absolute numbers of peripheral blood leukocytes...
August 2001: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/11382891/effects-of-48-hours-sleep-deprivation-on-human-immune-profile
#18
RANDOMIZED CONTROLLED TRIAL
L Oztürk, Z Pelin, D Karadeniz, H Kaynak, L Cakar, E Gözükirmizi
It is a common belief that sleep deprivation increases the susceptibility to diseases. In order to evaluate the effects of sleep deprivation on immune profile in humans, peripheral venous blood was obtained from sixteen healthy young male volunteers. Ten of the volunteers underwent 48 hours of sleep deprivation and the other six maintained their regular sleep schedule and acted as controls. The first blood samples were taken at the end of the first polysomnographic recording at 8:00 a.m. After this sampling, ten subjects were sleep deprived for 48 hours in sedentary conditions...
1999: Sleep Research Online: SRO
https://www.readbyqxmd.com/read/10919064/upper-respiratory-tract-infection-in-athletes-influence-of-lifestyle-type-of-sport-training-effort-and-immunostimulant-intake
#19
REVIEW
D König, D Grathwohl, C Weinstock, H Northoff, A Berg
Epidemiological evidence suggests that heavy acute or chronic exercise is related to an increased incidence of upper respiratory tract infections in athletes, while moderate exercise is believed to be protective. During the past years, many groups have investigated the association between changes within the immune system and exercise at different intensity levels. Although following strenuous exercise, some immunologic alterations were quite consistent and reproducible, e.g. neutrophilia, lymphopenia, and depression of natural killer cell activity, some findings were divergent or strongly dependent on the study design and athletes investigated...
2000: Exercise Immunology Review
https://www.readbyqxmd.com/read/10738860/white-blood-cells-and-cortisol-after-sleep-deprivation-and-recovery-sleep-in-humans
#20
P Heiser, B Dickhaus, W Schreiber, H W Clement, C Hasse, J Hennig, H Remschmidt, J C Krieg, W Wesemann, C Opper
Sleep deprivation (SD) has enriched our treatment programme for major depression. SD has been demonstrated to modify different host defence activities. There is some evidence that there are reciprocal relationships between immune function and increased hypothalamic-pituitary-adrenocortical (HPA) axis activity in depression. We therefore investigated the number of leukocytes, granulocytes, monocytes, lymphocytes, B cells, T cells, helper T cells, cytotoxic T cells, NK cells and salivary cortisol in 10 healthy men before and after total SD (TSD) as well as after recovery sleep...
2000: European Archives of Psychiatry and Clinical Neuroscience
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