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https://www.readbyqxmd.com/read/29245175/development-and-testing-of-a-hybrid-measure-of-muscle-strength-in-juvenile-dermatomyositis-for-use-in-routine-care
#1
Giulia Camilla Varnier, Silvia Rosina, Cristina Ferrari, Angela Pistorio, Alessandro Consolaro, Francesca Bovis, Sara Dalprà, Clarissa Pilkington, Susan Maillard, Adele Civino, Elena Tsitsami, Jaime de Inocencio, Marija Jelusic, Jelena Vojinovic, Graciela Espada, Balahan Makay, Maria Martha Katsicas, Polixeni Pratsidou-Gertsi, Dragana Lazarevic, Anand Prahalad Rao, Denise Pires Marafon, Nicolino Ruperto, Alberto Martini, Angelo Ravelli
OBJECTIVE: To develop and test a hybrid measure of muscle strength for juvenile dermatomyositis (JDM), which is based on the combination of the Manual Muscle Testing 8 (MMT8) and the Childhood Myositis Assessment Scale (CMAS), but is more comprehensive than the former and more feasible than the latter. METHODS: The hybrid MMT/CMAS (hMC) is composed of all 8 items of the MMT8 and 3 items of the CMAS: 1) time of head lift; 2) assessment of abdominal muscles; 3) floor rise...
December 15, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29244008/a-divide-and-conquer-algorithm-for-large-scale-de-novo-transcriptome-assembly-through-combining-small-assemblies-from-existing-algorithms
#2
Sing-Hoi Sze, Jonathan J Parrott, Aaron M Tarone
BACKGROUND: While the continued development of high-throughput sequencing has facilitated studies of entire transcriptomes in non-model organisms, the incorporation of an increasing amount of RNA-Seq libraries has made de novo transcriptome assembly difficult. Although algorithms that can assemble a large amount of RNA-Seq data are available, they are generally very memory-intensive and can only be used to construct small assemblies. RESULTS: We develop a divide-and-conquer strategy that allows these algorithms to be utilized, by subdividing a large RNA-Seq data set into small libraries...
December 6, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29243890/the-evolution-of-floral-ontogenetic-allometry-in-the-andean-genus-caiophora-loasaceae-subfam-loasoideae
#3
Marina Micaela Strelin, Santiago Benitez-Vieyra, Juan Fornoni, Christian Peter Klingenberg, Andrea Cocucci
The astounding variety of angiosperm flower morphologies has evolved in response to many selective forces. Flower development is highly coordinated and involves developmental associations between size and shape, ontogenetic allometry, which in turn affect the morphology of mature flowers. Although ontogenetic allometries can act as a developmental constraint and may influence adaptive evolution, allometries can evolve themselves and may change rapidly in response to selection. We explored the evolution of ontogenetic allometry in the flowers of 11 species of Loasoideae...
December 15, 2017: Evolution & Development
https://www.readbyqxmd.com/read/29243582/consensus-validation-of-simpler%C3%A2-a-tool-to-improve-pharmacist-delivery-of-quality-evidence-based-diabetes-care
#4
Shamala Ayadurai, V Bruce Sunderland, Lisa Bg Tee, H Laetitia Hattingh
BACKGROUND: Studies on a structured method used by pharmacists to provide comprehensive, evidence-based diabetes care are lacking. The aim of this study was to prioritise, rank and construct validate indicators categorised as seven treatment factors utilised in the management of diabetes namely: cholesterol, blood pressure and glycaemia control; medication and lifestyle management; cardiovascular risk strategies and education using the Delphi process. METHODS: A Delphi questionnaire consisted of 29 Part 1 and nine Part 2 indicators which were incorporated into a tool called Simpler™...
December 14, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/29242497/silicon-cmos-architecture-for-a-spin-based-quantum-computer
#5
M Veldhorst, H G J Eenink, C H Yang, A S Dzurak
Recent advances in quantum error correction codes for fault-tolerant quantum computing and physical realizations of high-fidelity qubits in multiple platforms give promise for the construction of a quantum computer based on millions of interacting qubits. However, the classical-quantum interface remains a nascent field of exploration. Here, we propose an architecture for a silicon-based quantum computer processor based on complementary metal-oxide-semiconductor (CMOS) technology. We show how a transistor-based control circuit together with charge-storage electrodes can be used to operate a dense and scalable two-dimensional qubit system...
December 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/29242179/individual-differences-in-the-relationship-between-attachment-and-nomophobia-among-college-students-the-mediating-role-of-mindfulness
#6
Ibrahim Arpaci, Mustafa Baloğlu, Hatice İrem Özteke Kozan, Şahin Kesici
BACKGROUND: There is a growing interest in nomophobia, which is defined as the fear of being out of cellular phone contact, or "feelings of discomfort or anxiety experienced by individuals when they are unable to use their mobile phones or utilize the affordances these devices provide". However, only limited research can be found in terms of its determinants at present. Contemporary literature suggests that the relationships among attachment styles, mindfulness, and nomophobia have not been investigated...
December 14, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29241667/correlates-of-ideal-cardiovascular-health-in-european-adolescents-the-helena-study
#7
P Henriksson, H Henriksson, I Labayen, I Huybrechts, L Gracia-Marco, F B Ortega, V España-Romero, Y Manios, M González-Gross, A Marcos, L A Moreno, Á Gutiérrez, J R Ruiz
BACKGROUND AND AIMS: The ideal cardiovascular health (iCVH) construct consists of 4 health behaviors (smoking status, body mass index, physical activity and diet) and 3 health factors (total cholesterol, blood pressure and fasting glucose). A greater number of iCVH components in adolescence are related to better cardiovascular health, but little is known about the correlates of iCVH in adolescents. Thus, the aim of the study was to examine correlates of iCVH in European adolescents. METHODS AND RESULTS: The study comprised 637 European adolescents with complete iCVH data...
October 28, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29241666/identification-of-human-circadian-genes-based-on-time-course-gene-expression-profiles-by-using-a-deep-learning-method
#8
Peng Cui, Tingyan Zhong, Zhuo Wang, Tao Wang, Hongyu Zhao, Chenglin Liu, Hui Lu
Circadian genes express periodically in an approximate 24-h period and the identification and study of these genes can provide deep understanding of the circadian control which plays significant roles in human health. Although many circadian gene identification algorithms have been developed, large numbers of false positives and low coverage are still major problems in this field. In this study we constructed a novel computational framework for circadian gene identification using deep neural networks (DNN) a deep learning algorithm which can represent the raw form of data patterns without imposing assumptions on the expression distribution...
December 11, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29241641/the-systemic-sclerosis-questionnaire-sysq-validation-of-the-translation-of-the-original-german-version-into-spanish-and-its-relationship-to-the-disease-and-to-quality-of-life
#9
Maria Pilar Cruz-Domínguez, Moisés Casarrubias-Ramírez, Victor Gasca-Martínez, Cindy Maldonado García, Rosa Angélica Carranza-Muleiro, Gabriela Medina, Grettel García-Collinot, Daniel Hector Montes-Cortes
OBJECTIVE: Translation, transculturation and validity of the self-administered questionnaire for functionality (Systemic Sclerosis Questionnaires [SySQ]) for use in Spanish patients with systemic sclerosis and its relationship to the severity of the disease and to quality of life. PATIENTS AND METHODS: We conducted an observational analytical study to perform a cross-cultural validation of the self-administered questionnaire on functionality in scleroderma. The validity of the form and content was evaluated by an expert panel...
December 11, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/29241512/development-of-post-hip-replacement-comfort-scale
#10
Hulya Saray Kilic, Sevinc Tastan
AIM: To develop and psychometrically test the Post Hip Replacement Comfort Scale (PHRCS). BACKGROUND: Evaluation of the patient comfort after hip replacement surgery is highly important in order to increase the quality of patient care. The review of the relevant literature shows that a scale that specifically measures the patient comfort after hip replacement surgery is absent. DESIGN: Methodological design was used. This study included the development of the scale and tested the psychometric properties of the scale...
December 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/29241439/family-decision-making-and-self-determination-among-consumers-with-schizophrenia-in-china-cross-cultural-implications
#11
Ying Chen, Chow S Lam, Hong Deng, Patrick W Corrigan, Eva Yau
OBJECTIVES: Self-determination is viewed as an important ingredient of successful recovery in psychiatric rehabilitation. The concept of autonomy, a key component of self-determination, may be of less importance in Chinese cultures, whereby an individual's choices may be in conflict with the family's expectations. This study aimed to develop an instrument to measure opinions about self-determination among Chinese consumers and their family members. METHODS: A 27-item questionnaire, the Consumer and Family Decision Making Scale (CFDMS), was constructed to measure consumers' and family members' views of self-determination in various aspects of daily life...
December 15, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29240816/the-sociotype-construct-gauging-the-structure-and-dynamics-of-human-sociality
#12
Pedro C Marijuán, Jesús Montero-Marín, Jorge Navarro, Javier García-Campayo, Raquel Del Moral
Exploring the pertinence of a "sociotype" construct, established along the conceptual chain genotype-phenotype-sociotype, is the essential purpose of the present paper. Further, by following the sociotype's conceptual guidelines, a new psychometric indicator has been developed in order to gauge the level of social interaction around each individual-the sociotype questionnaire (SOCQ). A first version of this questionnaire has been elaborated by gathering data about the different classes of social bonds (family, friends, acquaintances, and work/study colleagues) in general population and about the dynamic update of these bonds via face-to-face conversation and other modes of interaction...
2017: PloS One
https://www.readbyqxmd.com/read/29239862/co3o4-based-nonenzymatic-glucose-sensor-with-high-sensitivity-and-reliable-stability-derived-from-hollow-hierarchical-architecture
#13
Liangliang Tian, Gege He, Yanhua Cai, Shenping Wu, Yongyao Su, Hengqing Yan, Cong Yang, Yanling Chen, Lu Li
Inspired by kinetics, the design of hollow hierarchical electrocatalysts through large-scale integration of building blocks is recognized as an effective approach to achieve superior electrocatalytic performance. In this work, Co3O4 hollow hierarchical architecture (Co3O4 HHA) was constructed through coordinating etching and precipitating (CEP) method followed by calcination. The Co3O4 HHA electrode exhibits excellent electrocatalytic activity in terms of high sensitivity (839.3 µA mM-1 cm-2) and reliable stability towards the detection of glucose...
December 14, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29239532/a-3d-real-scale-biomimetic-and-biohybrid-model-of-the-blood-brain-barrier-fabricated-through-two-photon-lithography
#14
Attilio Marino, Omar Tricinci, Matteo Battaglini, Carlo Filippeschi, Virgilio Mattoli, Edoardo Sinibaldi, Gianni Ciofani
The investigation of the crossing of exogenous substances through the blood-brain barrier (BBB) is object of intensive research in biomedicine, and one of the main obstacles for reliable in vitro evaluations is represented by the difficulties at the base of developing realistic models of the barrier, which could resemble as most accurately as possible the in vivo environment. Here, for the first time, a 1:1 scale, biomimetic, and biohybrid BBB model is proposed. Microtubes inspired to the brain capillaries were fabricated through two-photon lithography and used as scaffolds for the co-culturing of endothelial-like bEnd...
December 14, 2017: Small
https://www.readbyqxmd.com/read/29239235/assessing-self-reported-disability-in-a-low-literate-population-with-chronic-low-back-pain-cross-cultural-adaptation-and-psychometric-testing-of-igbo-roland-morris-disability-questionnaire
#15
Chinonso N Igwesi-Chidobe, Chinwe Obiekwe, Isaac O Sorinola, Emma L Godfrey
PURPOSE: Cross-culturally adapt and validate the Igbo Roland Morris Disability Questionnaire. METHOD: Cross-cultural adaptation, test-retest, and cross-sectional psychometric testing. Roland Morris Disability Questionnaire was forward and back translated by clinical/non-clinical translators. An expert committee appraised the translations. Twelve participants with chronic low back pain pre-tested the measure in a rural Nigerian community. Internal consistency using Cronbach's alpha; test-retest reliability using intra-class correlation coefficient and Bland-Altman plot; and minimal detectable change were investigated in a convenient sample of 50 people with chronic low back pain in rural and urban Nigeria...
December 14, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29239206/the-reliability-and-validity-of-the-inventory-of-callous-unemotional-traits-a-meta-analytic-review
#16
Elise M Cardinale, Abigail A Marsh
In the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders, a Limited Prosocial Emotions specifier was added to the conduct disorder diagnostic criteria to designate a subgroup of children who exhibit callous unemotional (CU) traits. The Inventory of Callous Unemotional Traits (ICU) is the only dedicated measure of CU traits and was influential in the development of the Limited Prosocial Emotions specifier. Despite its role in the research and diagnosis of CU traits, some questions have persisted regarding the internal consistency and validity of the ICU and its three subscales: callous, uncaring, and unemotional...
December 1, 2017: Assessment
https://www.readbyqxmd.com/read/29238523/ad-hoc-instrumentation-methods-in-ecological-studies-produce-highly-biased-temperature-measurements
#17
Adam J Terando, Elsa Youngsteadt, Emily K Meineke, Sara G Prado
In light of global climate change, ecological studies increasingly address effects of temperature on organisms and ecosystems. To measure air temperature at biologically relevant scales in the field, ecologists often use small, portable temperature sensors. Sensors must be shielded from solar radiation to provide accurate temperature measurements, but our review of 18 years of ecological literature indicates that shielding practices vary across studies (when reported at all), and that ecologists often invent and construct ad hoc radiation shields without testing their efficacy...
December 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29238503/designing-and-validation-a-questionnaire-of-hope-for-family-members-of-patients-hospitalized-in-intensive-care-unit
#18
Foad Rahimi, Fatemeh Oskouie, Abbas Ebadi
Background: Families of patients are faced with stressors in the intensive care unit (ICU) that cannot be controlled sometimes. Having hope is one of the strategies for obtaining self-control in patients' families, which deals with such situations. Objective: The purpose of this study was to design and validate a questionnaire of hope for family members of patients hospitalized in intensive care units. Methods: This study was conducted for family members of patients hospitalized in the intensive care units of Kurdistan and Tehran provinces, in Iran, between the years 2015-2016...
October 2017: Electronic Physician
https://www.readbyqxmd.com/read/29237557/erepo-orp-exploring-the-opportunity-space-to-combat-orphan-diseases-with-existing-drugs
#19
Michal Brylinski, Misagh Naderi, Rajiv Gandhi Govindaraj, Jeffrey Lemoine
About 7000 rare, or orphan, diseases affect more than 350 million people worldwide. Although these conditions collectively pose significant health care problems, drug companies seldom develop drugs for orphan diseases due to extremely limited individual markets. Consequently, developing new treatments for often life-threatening orphan diseases is primarily contingent on financial incentives from governments, special research grants, and private philanthropy. Computer-aided drug repositioning is a cheaper and faster alternative to traditional drug discovery offering a promising venue for orphan drug research...
December 10, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29236718/particle-swarm-optimization-based-automatic-parameter-selection-for-deep-neural-networks-and-its-applications-in-large-scale-and-high-dimensional-data
#20
Fei Ye
In this paper, we propose a new automatic hyperparameter selection approach for determining the optimal network configuration (network structure and hyperparameters) for deep neural networks using particle swarm optimization (PSO) in combination with a steepest gradient descent algorithm. In the proposed approach, network configurations were coded as a set of real-number m-dimensional vectors as the individuals of the PSO algorithm in the search procedure. During the search procedure, the PSO algorithm is employed to search for optimal network configurations via the particles moving in a finite search space, and the steepest gradient descent algorithm is used to train the DNN classifier with a few training epochs (to find a local optimal solution) during the population evaluation of PSO...
2017: PloS One
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