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dental pulp capping

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https://www.readbyqxmd.com/read/28761141/effects-of-pulpotomy-using-mineral-trioxide-aggregate-on-prostaglandin-transporter-and-receptors-in-rat-molars
#1
Naoto Ohkura, Naoki Edanami, Ryosuke Takeuchi, Aiko Tohma, Mariko Ohkura, Nagako Yoshiba, Kunihiko Yoshiba, Hiroko Ida-Yonemochi, Hayato Ohshima, Takashi Okiji, Yuichiro Noiri
Mineral trioxide aggregate (MTA) is a commonly used dental pulp-capping material with known effects in promoting reparative dentinogenesis. However, the mechanism by which MTA induces dentine repair remains unclear. The aim of the present study was to investigate the role of prostaglandin E2 (PGE2) in dentine repair by examining the localisation and mRNA expression levels of its transporter (Pgt) and two of its receptors (Ep2 and Ep4) in a rat model of pulpotomy with MTA capping. Ep2 expression was detected in odontoblasts, endothelial cells, and nerve fibres in normal and pulpotomised tissues, whereas Pgt and Ep4 were immunolocalised only in the odontoblasts...
July 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28691235/outcomes-of-the-conventional-and-biological-treatment-approaches-for-the-management-of-caries-in-the-primary-dentition
#2
Alaa BaniHani, Monty Duggal, Jack Toumba, Chris Deery
BACKGROUND: In the last few years, conventional restorations including complete removal of carious tissue (CT) with or without pulp therapy for the treatment of carious lesions (CL) in primary teeth have been challenged and a more biological approach has been suggested. This approach involves the use of less invasive techniques which alter the environment of the CL isolating it from the cariogenic biofilm and substrate. Two of these treatment approaches that are becoming increasingly widely accepted and used in paediatric dentistry are the Hall Technique and indirect pulp capping (IPC)...
July 9, 2017: International Journal of Paediatric Dentistry
https://www.readbyqxmd.com/read/28675004/-confusion-and-solution-for-vital-pulp-therapy
#3
Huang Dingming, Lu Qian, Liao Qian, Ye Ling, Zhou Xuedong
Dental pulp tissue plays a role in forming dentin, providing nutrition, conducting pain, and generating protective responses to environmental stimuli. Bacterial infection is the main cause of pulp disease, where histopathological changes are the histological basis for determining the choice of treatment and the evaluation of therapeutic effect. Thus, particular attention should be given to eliminate infection, as well as preserve and maintain pulpal health in teeth that show reversible or limited pulpal injuries...
June 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28672895/role-of-transient-receptor-potential-channel-6-in-the-odontogenic-differentiation-of-human-dental-pulp-cells
#4
Xiaoting Yang, Zhi Song, Lingling Chen, Runfu Wang, Shuheng Huang, Wei Qin, Jia Guo, Zhengmei Lin
Pulp capping is a restorative technique employed in an attempt to maintain pulpal vitality and generate reparative dentin. Ca(2+) released from capping materials is suggested to promote reparative dentin formation. Transient receptor potential channel 6 (TRPC6) is a receptor-operated Ca2+ channel that serves an important role in Ca2+ influx in the majority of non-excitable cells, and influences the calcium signaling and cell respond. Therefore, the purpose of the present study was to gain an insight into the role of TRPC6 in the odontoblastic differentiation of human dental pulp cells (HDPCs)...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28663700/interleukin-6-expression-on-inflamed-rat-dental-pulp-tissue-after-capped-with-trigona-sp-propolis-from-south-sulawesi-indonesia
#5
Ardo Sabir, Andi Sumidarti
Background: Propolis is a natural product of plant resins collected by honeybees from various plant sources. It is used as a remedy in folk medicine since ancient times because of its several biological and pharmacological properties. Recently, propolis has been used by dentist to treat various oral diseases. It was always mentioned as an anti-inflammatory agent. Cytokines are proteins that provide communication between cells and play a critical role in a wide variety of processes. It released from cells in an inflammatory process that active, mediate or potential actions of other cells or tissues...
July 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28571484/sclerostin-deficiency-promotes-reparative-dentinogenesis
#6
A-M Collignon, N Amri, J Lesieur, J Sadoine, S Ribes, S Menashi, S Simon, A Berdal, G Y Rochefort, C Chaussain, C Gaucher
In humans, the SOST gene encodes sclerostin, an inhibitor of bone growth and remodeling, which also negatively regulates the bone repair process. Sclerostin has also been implicated in tooth formation, but its potential role in pulp healing remains unknown. The aim of this study was to explore the role of sclerostin in reparative dentinogenesis using Sost knockout mice ( Sost(-/-)). The pulps of the first maxillary molars were mechanically exposed in 3-mo-old Sost(-/-) and wild-type (WT) mice ( n = 14 mice per group), capped with mineral trioxide aggregate cement, and the cavities were filled with a bonded composite resin...
March 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28561919/current-trends-and-future-perspectives-of-dental-pulp-capping-materials-a-systematic-review
#7
REVIEW
Wellington L O da Rosa, Alexandra R Cocco, Tiago M da Silva, Luana C Mesquita, Arthur Dias Galarça, Adriana F da Silva, Evandro Piva
To systematically review the literature to analyze the current trends and future perspectives of dental pulp capping materials through an analysis of scientific and technological data. This study is reported in accordance with the PRISMA Statement. Nine databases were screened: PubMed (MedLine), Lilacs, IBECS, BBO, Web of Science, Scopus, SciELO, Google Scholar, and The Cochrane Library. Additionally, the following patent applications were searched online in Questel Orbit (Paris, France), USPTO, EPO, JPO, INPI, and Patentscope databases...
May 31, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28527850/complement-activation-by-pulp-capping-materials-plays-a-significant-role-in-both-inflammatory-and-pulp-stem-cells-recruitment
#8
Thomas Giraud, Pierre Rufas, Fanny Chmilewsky, Charlotte Rombouts, Jacques Dejou, Charlotte Jeanneau, Imad About
INTRODUCTION: The role of complement, especially through the C5a fragment, is well-known for the initiation of inflammation. Its involvement in regeneration has been shown more recently by the recruitment of mesenchymal stem cells. C5a can be produced locally by the pulp fibroblasts in response to injury or infection. This work aims to investigate the effect of different pulp capping biomaterials on complement activation and its possible influence on inflammatory and pulp stem cell recruitment...
May 17, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28518212/evaluation-of-cytotoxicity-and-ph-changes-generated-by-various-dental-pulp-capping-materials-an-in-vitro-study
#9
Elzbieta Luczaj-Cepowicz, Grazyna Marczuk-Kolada, Malgorzata Pawinska, Marta Obidzinska, Adam Holownia
INTRODUCTION: Various materials are used in direct dental pulp capping method. Their biocompatibility and alkalizing abilities are of primary importance affecting therapeutic effects. The aim of this study was to evaluate and compare the cytotoxicity of various pulp-capping materials on human gingival fibroblasts and investigate the pH changes induced by these materials. MATERIAL AND METHODS: Human gingival fibroblasts were cultured with nine direct pulp materials using culture plate inserts...
May 18, 2017: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/28512491/pulp-response-following-direct-pulp-capping-with-dentin-adhesives-and-mineral-trioxide-aggregate-an-animal-study
#10
Ali Akhavan, Farahnaz Arbabzadeh, Majid Bouzari, Sayed Mohammad Razavi, Amin Davoudi
INTRODUCTION: Pulp vitality and its continuous dentin prodution are essential for long-term success of direct pulp capping (DPC). The aim of present study was to evaluate the histopathological response of the canine pulp following DPC using either different dentin adhesive resins (DAR), calcium hydroxide (CH) or mineral trioxide aggregate (MTA). METHODS AND MATERIALS: DPC was done on 72 dog's teeth using 6 types of dental materials (n=12) (4 types of DAR, white MTA and CH)...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/28493112/the-teaching-of-management-of-the-pulp-in-primary-molars-across-europe
#11
J Monteiro, A Ní Chaollaí, M Duggal
AIM: To determine which methods of primary pulp therapy are currently being taught in European dental schools. METHODS: An online survey tool was employed to send questionnaires to paediatric dentistry departments of 202 European dental schools. Email addresses were obtained from the European Academy of Paediatric Dentistry and questionnaires were sent to one member of each department in December 2014. The survey included questions on treatment choices and clinical scenarios where respondents indicated how they would advise students to proceed, given a particular case...
June 2017: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/28462406/effectiveness-of-radio-waves-application-in-modern-general-dental-procedures-an-update
#12
Arslan Qureshi, Sergio Varela Kellesarian, Michael A Pikos, Fawad Javed, Georgios E Romanos
OBJECTIVE: The purpose of the present study was to review indexed literature and provide an update on the effectiveness of high-frequency radio waves (HRW) application in modern general dentistry procedures. DATA SOURCES: Indexed databases were searched to identify articles that assessed the efficacy of radio waves in dental procedures. RESULTS: Radiosurgery is a refined form of electrosurgery that uses waves of electrons at a radiofrequency ranging between 2 and 4 MHz...
April 28, 2017: Quintessence International
https://www.readbyqxmd.com/read/28415511/facile-synthesis-and-characterization-of-novel-rapid-setting-spherical-sub-micron-bioactive-glasses-cements-and-their-biocompatibility-in-vitro
#13
Yuli Li, Qiming Liang, Cai Lin, Xian Li, Xiaofeng Chen, Qing Hu
Dental pulp vitality is extremely important for the tooth viability, since it provides nutrition and forms the dentin. Bioactive glasses (BGs) may be promising materials for pulp repair due to their excellent abilities of rapidly bonding to bone and stimulating new bone growth. However, the unsatisfied handling property, low plasticity, and poor rapid-setting property of traditional BGs limit its application in vital pulp therapy. Spherical bioactive glasses (SBGs) exhibited higher osteogenesis and odontogenic differentiation than irregular BGs...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28342006/potential-synergistic-effects-of-a-mixture-of-mineral-trioxide-aggregate-mta-cement-and-bacillus-subtilis-in-dental-caries-treatment
#14
Shunya Oka
Bacillus subtilis is nonpathogenic in humans and produces a number of useful substances and, therefore, this bacterium is used in probiotic therapy. There have been trials of B. subtilis for patients with periodontitis, but not for patients with caries. Similarly, mineral trioxide aggregate (MTA) cement has been widely used for endodontic treatment, but there are few reports of its use for caries. Therefore, examinations were performed regarding the benefits of addition of B. subtilis to MTA cement for treatment of dental caries...
March 24, 2017: Odontology
https://www.readbyqxmd.com/read/28331230/dentin-sialoprotein-facilitates-dental-mesenchymal-cell-differentiation-and-dentin-formation
#15
Wentong Li, Lei Chen, Zhuo Chen, Lian Wu, Junsheng Feng, Feng Wang, Lisa Shoff, Xin Li, Kevin J Donly, Mary MacDougall, Shuo Chen
Dentin sialoprotein (DSP) is a dentin extracellular matrix protein. It is involved in dental mesenchymal cell lineages and dentin formation through regulation of its target gene expression. DSP mutations cause dentin genetic diseases. However, mechanisms of DSP in controlling dental mesenchymal cell differentiation are unknown. Using DSP as bait, we screened a protein library from mouse odontoblastic cells and found that DSP is a ligand and binds to cell surface receptor, occludin. Further study identified that the C-terminal DSP domain(aa 363-458) interacts with the occludin extracellular loop 2(aa 194-241)...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28292713/transforming-growth-factor-%C3%AE-induced-gene-product-h3-inhibits-odontoblastic-differentiation-of-dental-pulp-cells
#16
Suguru Serita, Atsushi Tomokiyo, Daigaku Hasegawa, Sayuri Hamano, Hideki Sugii, Shinichiro Yoshida, Hiroyuki Mizumachi, Hiromi Mitarai, Satoshi Monnouchi, Naohisa Wada, Hidefumi Maeda
OBJECTIVE: The aim of this study was to investigate transforming growth factor-β-induced gene product-h3 (βig-h3) expression in dental pulp tissue and its effects on odontoblastic differentiation of dental pulp cells (DPCs). DESIGN: A rat direct pulp capping model was prepared using perforated rat upper first molars capped with mineral trioxide aggregate cement. Human DPCs (HDPCs) were isolated from extracted teeth. βig-h3 expression in rat dental pulp tissue and HDPCs was assessed by immunostaining...
February 24, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28257221/preservation-in-young-patients-of-pulp-vitality-and-anatomical-functional-restoration-of-the-lost-structure
#17
Carlos Andres Villavicencio Espinoza, Juan Fernando Ordoñez Aguilera, Fabio Antonio Piola Rizzante, Rafael Massunari Maenosono, Eduardo Batista Franco, Sérgio Kiyoshi Ishikiriama
Often, young patients (≤30 years old) present with carious lesions that progress acutely, compromising a large amount of tooth structure. In these cases, a treatment to prevent the occurrence of pulp exposure and promote remineralization of caries-affected dentin is necessary to maintain healthy dental structure and allow more conservative interventions. The approach will be different when pulp exposure occurs: The therapeutic treatments will be focused on reparative dentin formation and prevention of microorganisms penetrating the pulp organ...
March 2017: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/28241819/response-of-human-dental-pulp-cells-to-a-silver-containing-plga-tcp-nanofabric-as-a-potential-antibacterial-regenerative-pulp-capping-material
#18
Barbara Cvikl, Samuel C Hess, Richard J Miron, Hermann Agis, Dieter Bosshardt, Thomas Attin, Patrick R Schmidlin, Adrian Lussi
BACKGROUND: Damage or exposure of the dental pulp requires immediate therapeutic intervention. METHODS: This study assessed the biocompatibility of a silver-containing PLGA/TCP-nanofabric scaffold (PLGA/Ag-TCP) in two in vitro models, i.e. the material adapted on pre-cultured cells and cells directly cultured on the material, respectively. Collagen saffolds with and without hyaluronan acid (Coll-HA; Coll) using both cell culturing methods and cells growing on culture plates served as reference...
February 27, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28206897/retrospective-study-of-the-survival-rates-of-indirect-pulp-therapy-versus-different-pulpotomy-medicaments
#19
Patrice Barsamian Wunsch, Marissa M Kuhnen, Al M Best, Tegwyn H Brickhouse
PURPOSE: The purposes of this retrospective chart review were to determine: (1) how primary molars in need of vital pulp therapy (VPT) have been treated over a period of four years at a university-based pediatric dental practice (UBP); and which treatments-indirect pulp therapy (IPT), formocresol pulpotomy (FCP), and ferric sulfate pulpotomy (FSP)-have been successful. METHODS: Electronic patient records (axiUm) that contained the procedure codes D3120 (pulp cap-indirect) or D3220 (therapeutic pulpotomy) were totaled by year...
October 15, 2016: Pediatric Dentistry
https://www.readbyqxmd.com/read/28198096/treated-dentin-matrix-paste-as-a-novel-pulp-capping-agent-for-dentin-regeneration
#20
Jinlong Chen, Caiyun Cui, Xiangchen Qiao, Bo Yang, Mei Yu, Weihua Guo, Weidong Tian
Regenerating dentin and preserving pulp vitality are the two key targets for the treatment of dental pulp exposure. Calcium hydroxide (CH), the widely used capping agent, may induce potential tunnel defect in reparative dentin and cause inflammation or even necrosis in pulp tissues. This study aimed to produce a novel pulp capping agent with better bioactivities. Treated dentin matrix (TDM) paste (TDMP) was fabricated consisting of TDM powder and aqueous TDM extract. The chemical and biological characteristics of TDMP were investigated, and its effect on the odontogenic differentiation of dental pulp stem cells explored at gene and protein level; the therapeutic effect for pulp exposure in miniature swine was further verified...
February 15, 2017: Journal of Tissue Engineering and Regenerative Medicine
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