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dental pulp capping

Fan Yu, Yan Dong, Yan-Wei Yang, Ping-Ting Lin, Hao-Han Yu, Xiang Sun, Xue-Fei Sun, Huan Zhou, Li Huang, Ji-Hua Chen
Effective pulp-capping materials must have antibacterial properties and induce dentin bridge formation; however, many current materials do not satisfy clinical requirements. Accordingly, the effects of an experiment pulp-capping material (Exp) composed of an antibacterial resin monomer (MAE-DB) and Portland cement (PC) on the viability, adhesion, migration, and differentiation of human dental pulp stem cells (hDPSCs) were examined. Based on a Cell Counting Kit-8 assay, hDPSCs exposed to Exp extracts showed limited viability at 24 and 48 h, but displayed comparable viability to the control at 72 h...
October 4, 2016: Scientific Reports
Fawad Javed, Sergio Varela Kellesarian, Tariq Abduljabbar, Elham Gholamiazizi, Changyong Feng, Khaled Aldosary, Fahim Vohra, Georgios E Romanos
A variety of materials are available to treat exposed dental pulp by direct pulp capping. The healing response of the pulp is crucial to form a dentin bridge and seal off the exposed pulp. Studies have used lasers to stimulate the exposed pulp to form tertiary dentin. The aim of the present systematic review and meta-analysis was to evaluate the evidence on the effects of laser irradiation as an adjunctive therapy to stimulate healing after pulp exposure. A systematic literature search was conducted up to April 2016...
September 23, 2016: Lasers in Medical Science
B Z Mello, T C Stafuzza, L L R Vitor, D Rios, M A Machado, T M Oliveira
BACKGROUND: Minimally-invasive techniques for the management of carious dental tissue has been well documented. This study aimed to report on the clinical and radiographic response after partial caries removal on left mandibular primary second molar. CASE REPORT: A 6-year-old boy sought treatment because of pain in the left mandibular primary second molar. The tooth had a deep caries lesion on the occlusal surface, with loss of enamel structure and dentine proximity with the pulp confirmed by periapical radiograph...
October 2016: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
Maryam Amin, M-Reza Nouri, Sarah Hulland, Mohamed ElSalhy, Amir Azarpazhooh
PURPOSE: The purpose of this study was to assess the success rate of various treatments provided under general anesthesia for early childhood caries (ECC) over three-year follow-up period. METHODS: ECC children no older than 72 months at the time of dental surgery, who had completed a three-year follow-up, were included. The success rate of every treatment was evaluated. The longevity of each treatment and significant factors associated with failures were assessed...
2016: Pediatric Dentistry
W X He, N N Liu, X L Wang, X Y He
Since laser was introduced in the field of medicine in 1970's, its application range has continuously expanded. The application of laser in endodontics also increased due to its safety and effectiveness in dental treatments. The majority of the laser application researches in dentistry focused on dentin hypersensitivity, removal of carious tissues, tooth preparations, pulp capping or pulpotomy, and root canal treatment. In this article, we reviewed literature on the effects of laser in the treatments of dental and pulp diseases...
August 2016: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
Yu-Chih Chiang, Hao-Hueng Chang, Ching-Ching Wong, Yi-Ping Wang, Yin-Lin Wang, Wen-Hsuan Huang, Chun-Pin Lin
OBJECTIVES: Vital pulp therapy aims to treat reversible pulpal injuries via protective dentinogenesis and to preserve more tooth structure. Mineral trioxide aggregate (MTA)-based capping materials demonstrate prolonged setting time increases the risk of pulpal infection during multi-visit treatment. Their non-degradable property occupies pulp space and limits dentin-pulp regeneration. This study reports an inorganic degradable biomaterial that presents a short initial setting time and acts as a growth factor reservoir to promote reparative dentinogenesis...
October 2016: Dental Materials: Official Publication of the Academy of Dental Materials
Sartika Puspita, Totok Utoro, Tetiana Haniastuti
OBJECTIVE: The aim of this study was to evaluate nestin expression of pulp tissue following direct pulp capping with platelet-rich plasma (PRP). MATERIALS AND METHODS: The thirty sound teeth from Sprague-Dawley rats were used and divided into two groups: Groups 1, teeth were capped with calcium hydroxide/Ca(OH)2 (n = 15) and Group 2 with PRP (n = 15). After 1(st), 7(th), and 21(st) days, respectively, 5 teeth each group (American Dental Association 41) were processed for light microscopic examination...
July 2016: European Journal of Dentistry
Luoping Chen, Lisha Zheng, Jingyi Jiang, Jinpeng Gui, Lingyu Zhang, Yan Huang, Xiaofang Chen, Jing Ji, Yubo Fan
INTRODUCTION: Calcium hydroxide has been extensively used as the gold standard for direct pulp capping in clinical dentistry. It induces proliferation, migration, and mineralization in dental pulp stem cells (DPSCs), but the underlying mechanisms are still unclear. The aim of this study was to investigate the role of the mitogen-activated protein (MAP) kinase pathway in calcium hydroxide-induced proliferation, migration, osteogenic differentiation, and mineralization in human DPSCs...
September 2016: Journal of Endodontics
V Smaïl-Faugeron, A Porot, M Muller-Bolla, F Courson
AIM: To assess dental practice regarding the use of indirect pulp capping or pulpotomy in children with deep carious lesions approaching the pulp in primary teeth and to compare the efficacy of the two pulp treatments. METHODS: HASH(0x37dae88) STUDY DESIGN: Systematic review. We searched the Cochrane Library, PubMed via MEDLINE, and EMBASE as well as the reference lists of included reports and (for ongoing trials). Eligible studies were surveys of dental practice sent to dentists regarding the use of indirect pulp capping and pulpotomy in children with deep carious lesions approaching the pulp in primary teeth and any type of clinical study...
June 2016: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
N Han, Z Chen, Q Zhang
AIM: To identify whether Krüppel-like factor 5 (KLF5) was involved in odontoblastic differentiation during reparative dentine formation. METHODOLOGY: Human DPCs were isolated from healthy human dental pulp tissue and induced for odontoblastic differentiation. Alizarin Red staining, alkaline phosphatase (ALPase) activity, Quantitative real-time PCR and Western Blot were performed to evaluate in vitro odontoblastic differentiation. The expression profile of KLF5 during the in vitro odontoblastic differentiation was determined by Quantitative real-time PCR and Western Blot...
June 23, 2016: International Endodontic Journal
S Yoshida, N Wada, D Hasegawa, H Miyaji, H Mitarai, A Tomokiyo, S Hamano, H Maeda
In cases of pulp exposure due to deep dental caries or severe traumatic injuries, existing pulp-capping materials have a limited ability to reconstruct dentin-pulp complexes and can result in pulpectomy because of their low potentials to accelerate dental pulp cell activities, such as migration, proliferation, and differentiation. Therefore, the development of more effective therapeutic agents has been anticipated for direct pulp capping. Dental pulp tissues are enriched with dental pulp stem cells (DPSCs)...
October 2016: Journal of Dental Research
Shaofeng An, Qimei Gong, Yihua Huang
Zinc is an essential trace element for proper cellular function and bone formation. However, its exact role in the osteogenic differentiation of human dental pulp cells (hDPCs) has not been fully clarified before. Here, we speculated that zinc may be effective to regulate their growth and osteogenic differentiation properties. To test this hypothesis, different concentrations (1 × 10(-5), 4 × 10(-5), and 8 × 10(-5) M) of zinc ions (Zn(2+)) were added to the basic growth culture medium and osteogenic inductive medium...
June 4, 2016: Biological Trace Element Research
Weiqian Jia, Yuming Zhao, Jie Yang, Wenjun Wang, Xu Wang, Long Ling, Lihong Ge
INTRODUCTION: Pulpotomy is a specific treatment used to save root pulp, in which only the inflamed coronal pulp is removed and capping materials are placed. Our study aims to study the effect of simvastatin (1) on the proliferation and differentiation of dental pulp stem cells (DPSCs) and (2) on DPSC-induced pulp regeneration after pulpotomy. METHODS: DPSCs were treated with different concentrations of simvastatin. Cell counting kit-8 activity was examined to test cell proliferation, and alkaline phosphatase assays and alizarin red S staining were conducted to examine differentiation...
July 2016: Journal of Endodontics
Luciano Casagrande, Alejandra Tejeda Seminario, Marcos Britto Correa, Stefanie Bressan Werle, Marisa Maltz, Flávio Fernando Demarco, Fernando Borba de Araujo
OBJECTIVE: The aim of this retrospective university-based study has been to evaluate the longevity and factors associated with failures of adhesive restorations performed in deep carious lesions of permanent molars after complete (CCR) and selective caries removal (SCR). MATERIALS AND METHODS: The sample was composed of composite resin and resin-modified glass ionomer cement (RMGIC) restorations placed in permanent molars of children attending a university dental service who were followed up for up to 36 months...
April 22, 2016: Clinical Oral Investigations
M Kimura, T Sase, A Higashikawa, M Sato, T Sato, M Tazaki, Y Shibukawa
Calcium hydroxide and mineral trioxide aggregate are widely used for indirect and direct pulp capping and root canal filling. Their dissociation into Ca(2+) and OH(-) in dental pulp creates an alkaline environment, which activates reparative/reactionary dentinogenesis. However, the mechanisms by which odontoblasts detect the pH of the extracellular environment remain unclear. We examined the alkali-sensitive intracellular Ca(2+) signaling pathway in rat odontoblasts. In the presence or absence of extracellular Ca(2+), application of alkaline solution increased intracellular Ca(2+) concentration, or [Ca(2+)]i Alkaline solution-induced [Ca(2+)]i increases depended on extracellular pH (8...
August 2016: Journal of Dental Research
J Y Jung, S M Woo, W J Kim, B N Lee, J E Nör, K S Min, C H Choi, J T Koh, K J Lee, Y C Hwang
AIM: To investigate the effect of simvastatin on lipopolysaccharide (LPS) stimulated inflammatory cytokines, cell adhesion molecules, and Nuclear factor-κB (NF-κB) transcription factors in human dental pulp cells (HDPCs) METHODOLOGY: The effect of LPS and simvastatin on human dental pulp cell (HDPCs) viability was measured using a 3-[4, 5-dimethylthiazol-2-yl]-2, 5 diphenyltetrazolium bromide (MTT) assay. Expression of inflammatory cytokines and cell adhesion molecules was evaluated by reverse transcription-polymerase chain reaction (RT-PCR), enzyme-linked immunosorbent assay (ELISA), and Western blot analysis...
March 22, 2016: International Endodontic Journal
Yujiro Hirose, Masaya Yamaguchi, Shigetada Kawabata, Masashi Murakami, Misako Nakashima, Momokazu Gotoh, Tokunori Yamamoto
INTRODUCTION: The proliferation and migration of dental pulp stem cells (DPSCs), a population comprised of dental pulp cells (DPCs), are important processes for pulp tissue repair. Dental pulp is exposed to changes in extracellular pH under various conditions, such as acidosis and exposure to caries-associated bacteria or a pulp capping agent. The objective of this study was to investigate the effects of extracellular pH on DPC proliferation and migration in vitro. METHODS: To evaluate the proliferation potency of DPCs in various extracellular pH conditions, 2 × 10(4) cells were seeded into 35-mm dishes...
May 2016: Journal of Endodontics
P L Tomson, P J Lumley, A J Smith, P R Cooper
AIM: To characterise growth factor release from dentine by pulp capping agents and to determine the effects of liberated dentine extracellular matrix (dECM) components on pulp cells in the key wound healing processes of migration and cell growth. METHODOLOGY: Powdered human dentine was exposed to solutions of calcium hydroxide, white and grey Mineral Trioxide Aggregate (MTA) (ProRoot, (Dentsply Tulsa, Tulsa, OK, USA) over 14 days. The solubilised dECM components were dialysed and lyophilised and characterised using multiplex quantitative ELISA...
February 23, 2016: International Endodontic Journal
Steven R Jefferies
Vital pulp therapy is the general concept involved in the "regenerative" restorative treatment of the reversibly injured dental pulp with the intention of maintaining its vitality in a restored, functioning tooth. While this procedure has been attempted with various materials and techniques over a period of several centuries, the advent of hard-setting calcium hydroxide materials in the late 1950s made the procedure of direct pulp capping a more routine and relatively predictable procedure. More recently, in the mid 1990s, a new type of water-based, "hydraulic-type," calcium silicate-based cement, mineral trioxide aggregate (MTA), was introduced to dentistry as a possible alternative to the established standard of hard-setting calcium hydroxide...
March 2016: Journal of Esthetic and Restorative Dentistry
Takashi Komabayashi, Qiang Zhu, Robert Eberhart, Yohji Imai
Direct pulp-capping is a method for treating exposed vital pulp with dental material to facilitate the formation of reparative dentin and to maintain vital pulp. Two types of pulp-capping materials, calcium hydroxide and mineral trioxide aggregate, have been most commonly used in clinics, and an adhesive resin has been considered a promising capping material. However, until now, there has been no comprehensive review of these materials. Therefore, in this paper, the composition, working mechanisms and clinical outcome of these types of pulp-capping materials are reviewed...
2016: Dental Materials Journal
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