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dental pulp capping

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https://www.readbyqxmd.com/read/28415511/facile-synthesis-and-characterization-of-novel-rapid-setting-spherical-sub-micron-bioactive-glasses-cements-and-their-biocompatibility-in-vitro
#1
Yuli Li, Qiming Liang, Cai Lin, Xian Li, Xiaofeng Chen, Qing Hu
Dental pulp vitality is extremely important for the tooth viability, since it provides nutrition and forms the dentin. Bioactive glasses (BGs) may be promising materials for pulp repair due to their excellent abilities of rapidly bonding to bone and stimulating new bone growth. However, the unsatisfied handling property, low plasticity, and poor rapid-setting property of traditional BGs limit its application in vital pulp therapy. Spherical bioactive glasses (SBGs) exhibited higher osteogenesis and odontogenic differentiation than irregular BGs...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28342006/potential-synergistic-effects-of-a-mixture-of-mineral-trioxide-aggregate-mta-cement-and-bacillus-subtilis-in-dental-caries-treatment
#2
Shunya Oka
Bacillus subtilis is nonpathogenic in humans and produces a number of useful substances and, therefore, this bacterium is used in probiotic therapy. There have been trials of B. subtilis for patients with periodontitis, but not for patients with caries. Similarly, mineral trioxide aggregate (MTA) cement has been widely used for endodontic treatment, but there are few reports of its use for caries. Therefore, examinations were performed regarding the benefits of addition of B. subtilis to MTA cement for treatment of dental caries...
March 24, 2017: Odontology
https://www.readbyqxmd.com/read/28331230/dentin-sialoprotein-facilitates-dental-mesenchymal-cell-differentiation-and-dentin-formation
#3
Wentong Li, Lei Chen, Zhuo Chen, Lian Wu, Junsheng Feng, Feng Wang, Lisa Shoff, Xin Li, Kevin J Donly, Mary MacDougall, Shuo Chen
Dentin sialoprotein (DSP) is a dentin extracellular matrix protein. It is involved in dental mesenchymal cell lineages and dentin formation through regulation of its target gene expression. DSP mutations cause dentin genetic diseases. However, mechanisms of DSP in controlling dental mesenchymal cell differentiation are unknown. Using DSP as bait, we screened a protein library from mouse odontoblastic cells and found that DSP is a ligand and binds to cell surface receptor, occludin. Further study identified that the C-terminal DSP domain(aa 363-458) interacts with the occludin extracellular loop 2(aa 194-241)...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28292713/transforming-growth-factor-%C3%AE-induced-gene-product-h3-inhibits-odontoblastic-differentiation-of-dental-pulp-cells
#4
Suguru Serita, Atsushi Tomokiyo, Daigaku Hasegawa, Sayuri Hamano, Hideki Sugii, Shinichiro Yoshida, Hiroyuki Mizumachi, Hiromi Mitarai, Satoshi Monnouchi, Naohisa Wada, Hidefumi Maeda
OBJECTIVE: The aim of this study was to investigate transforming growth factor-β-induced gene product-h3 (βig-h3) expression in dental pulp tissue and its effects on odontoblastic differentiation of dental pulp cells (DPCs). DESIGN: A rat direct pulp capping model was prepared using perforated rat upper first molars capped with mineral trioxide aggregate cement. Human DPCs (HDPCs) were isolated from extracted teeth. βig-h3 expression in rat dental pulp tissue and HDPCs was assessed by immunostaining...
February 24, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28257221/preservation-in-young-patients-of-pulp-vitality-and-anatomical-functional-restoration-of-the-lost-structure
#5
Carlos Andres Villavicencio Espinoza, Juan Fernando Ordoñez Aguilera, Fabio Antonio Piola Rizzante, Rafael Massunari Maenosono, Eduardo Batista Franco, Sérgio Kiyoshi Ishikiriama
Often, young patients (≤30 years old) present with carious lesions that progress acutely, compromising a large amount of tooth structure. In these cases, a treatment to prevent the occurrence of pulp exposure and promote remineralization of caries-affected dentin is necessary to maintain healthy dental structure and allow more conservative interventions. The approach will be different when pulp exposure occurs: The therapeutic treatments will be focused on reparative dentin formation and prevention of microorganisms penetrating the pulp organ...
March 2017: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/28241819/response-of-human-dental-pulp-cells-to-a-silver-containing-plga-tcp-nanofabric-as-a-potential-antibacterial-regenerative-pulp-capping-material
#6
Barbara Cvikl, Samuel C Hess, Richard J Miron, Hermann Agis, Dieter Bosshardt, Thomas Attin, Patrick R Schmidlin, Adrian Lussi
BACKGROUND: Damage or exposure of the dental pulp requires immediate therapeutic intervention. METHODS: This study assessed the biocompatibility of a silver-containing PLGA/TCP-nanofabric scaffold (PLGA/Ag-TCP) in two in vitro models, i.e. the material adapted on pre-cultured cells and cells directly cultured on the material, respectively. Collagen saffolds with and without hyaluronan acid (Coll-HA; Coll) using both cell culturing methods and cells growing on culture plates served as reference...
February 27, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28206897/retrospective-study-of-the-survival-rates-of-indirect-pulp-therapy-versus-different-pulpotomy-medicaments
#7
Patrice Barsamian Wunsch, Marissa M Kuhnen, Al M Best, Tegwyn H Brickhouse
PURPOSE: The purposes of this retrospective chart review were to determine: (1) how primary molars in need of vital pulp therapy (VPT) have been treated over a period of four years at a university-based pediatric dental practice (UBP); and which treatments-indirect pulp therapy (IPT), formocresol pulpotomy (FCP), and ferric sulfate pulpotomy (FSP)-have been successful. METHODS: Electronic patient records (axiUm) that contained the procedure codes D3120 (pulp cap-indirect) or D3220 (therapeutic pulpotomy) were totaled by year...
October 15, 2016: Pediatric Dentistry
https://www.readbyqxmd.com/read/28198096/treated-dentin-matrix-paste-as-a-novel-pulp-capping-agent-for-dentin-regeneration
#8
Jinlong Chen, Caiyun Cui, Xiangchen Qiao, Bo Yang, Mei Yu, Weihua Guo, Weidong Tian
Regenerating dentin and preserving pulp vitality are the two key targets for the treatment of dental pulp exposure. Calcium hydroxide (CH), the widely used capping agent, may induce potential tunnel defect in reparative dentin and cause inflammation or even necrosis in pulp tissues. This study aimed to produce a novel pulp capping agent with better bioactivities. Treated dentin matrix (TDM) paste (TDMP) was fabricated consisting of TDM powder and aqueous TDM extract. The chemical and biological characteristics of TDMP were investigated, and its effect on the odontogenic differentiation of dental pulp stem cells explored at gene and protein level; the therapeutic effect for pulp exposure in miniature swine was further verified...
February 15, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28117776/development-of-a-direct-pulp-capping-model-for-the-evaluation-of-pulpal-wound-healing-and-reparative-dentin-formation-in-mice
#9
Minju Song, Sol Kim, Terresa Kim, Sil Park, Ki-Hyuk Shin, Mo Kang, No-Hee Park, Reuben Kim
Dental pulp is a vital organ of a tooth fully protected by enamel and dentin. When the pulp is exposed due to cariogenic or iatrogenic injuries, it is often capped with biocompatible materials in order to expedite pulpal wound healing. The ultimate goal is to regenerate reparative dentin, a physical barrier that functions as a "biological seal" and protects the underlying pulp tissue. Although this direct pulp-capping procedure has long been used in dentistry, the underlying molecular mechanism of pulpal wound healing and reparative dentin formation is still poorly understood...
January 12, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28043847/nanoscale-chemical-surface-characterization-of-four-different-types-of-dental-pulp-capping-materials
#10
Victor Gong, Rodrigo França
OBJECTIVES: The surface of any dental pulp-capping material has important implications for its clinical success because it is in direct contact with dental tissue, which influences its cytotoxicity. The aim was to determine the chemical composition of the first atomic layers of four pulp-protection agents because these atoms can initiate the pulp healing process. METHODS: Biodentine (Septodont), ProRoot MTA (Dentsply), Dycal (Caulk) and TheraCal (Bisco) were prepared (n=5) according to manufacturer recommendations...
December 30, 2016: Journal of Dentistry
https://www.readbyqxmd.com/read/28033065/effects-of-bioactive-compounds-on-odontogenic-differentiation-and-mineralization
#11
S Phung, C Lee, C Hong, M Song, J K Yi, R G Stevenson, M K Kang, K-H Shin, N-H Park, R H Kim
Direct pulp capping involves the placement of dental materials directly onto vital pulp tissues after deep caries removal to stimulate the regeneration of reparative dentin. This physical barrier will serve as a "biological seal" between these materials and the pulp tissue. Although numerous direct pulp capping materials are available, the use of small bioactive compounds that can potently stimulate and expedite reparative dentin formation is still underexplored. Here, the authors compared and evaluated the pro-osteogenic and pro-odontogenic effects of 4 small bioactive compounds- phenamil (Phen), purmorphamine (Pur), genistein (Gen), and metformin (Met)...
January 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28000038/management-of-pulps-exposed-during-carious-tissue-removal-in-adults-a-multi-national-questionnaire-based-survey
#12
Lina Stangvaltaite, Falk Schwendicke, Christopher Holmgren, Marion Finet, Marisa Maltz, Karim Elhennawy, Eero Kerosuo, Sophie Doméjean
OBJECTIVES: The aim of the present study was to investigate and compare the management of pulps exposed during carious tissue removal by French, German, and Norwegian general dental practitioners (GDPs). We further aimed to assess possible dentist- and patient-related factors associated with these management decisions. MATERIALS AND METHODS: A structured questionnaire was send via mail to a simple random sample of dentists. RESULTS: The analyzed sample consisted of 661 (33%) French GDPs, 622 (25%) German GDPs, and 199 (34%) Norwegian GDPs...
December 20, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27998031/could-the-application-of-bioactive-molecules-improve-vital-pulp-therapy-success-a-systematic-review
#13
REVIEW
Wellington Luiz de Oliveira da Rosa, Tiago Machado da Silva, Flávio Fernando Demarco, Evandro Piva, Adriana Fernandes da Silva
This study aimed to systematically review the literature of animal studies to evaluate whether bioactive dentin proteins could improve vital pulp therapy success. The review is reported in accordance with the PRISMA Statement. Two reviewers independently conducted a literature search of seven databases: PubMed (Medline), Lilacs, IBECS, BBO, Web of Science, Scopus, and SciELO. Animal experiments in which bioactive dentin proteins were applied directly or indirectly to the pulp tissue were included. Data regarding the characteristics of the proteins evaluated, the delivery systems used and the main findings from each study were tabulated to assess the outcomes of interest (tertiary dentin formation, inflammatory response, intratubular mineralization)...
March 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27928102/cytotoxicity-and-biocompatibility-of-resin-free-and-resin-modified-direct-pulp-capping-materials-a-state-of-the-art-review
#14
Liang Chen, Byoung In Suh
Direct pulp capping is the placement of a dental material directly over exposed pulp to prevent dental pulp from dying and avoid the need for root canal treatments. Calcium hydroxide and calcium silicates/mineral trioxide aggregates (MTA) have been commonly used for direct pulp capping with great success clinically. In recent years, resin-modified calcium hydroxide and calcium silicates have been developed with the advantages of precise placement, command set, and superior physical strength. As pulp capping materials would be in direct contact with the pulp, the cytotoxicity and biocompatibility is of particular importance in order to avoid pulp irritation and maintain pulp vitality...
December 6, 2016: Dental Materials Journal
https://www.readbyqxmd.com/read/27892627/withdrawn-pulp-management-for-caries-in-adults-maintaining-pulp-vitality
#15
REVIEW
Hiroshi Miyashita, Helen V Worthington, Alison Qualtrough, Alphons Plasschaert
BACKGROUND: There is a range of treatment options for the management of the pulp in extensively decayed teeth. These include direct and indirect pulp capping, pulpotomy or pulpectomy. If the tooth is symptomatic or if there are periapical bone changes, then endodontic treatment is required. However, if the tooth is asymptomatic but the caries is extensive, there is no consensus as to the best method of management. In addition, there has been a recent move towards using alternative materials and methods such as the direct or indirect placement of bonding agents and mineral trioxide aggregate...
November 28, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27891629/capping-carious-exposures-in-adults-a-randomized-controlled-trial-investigating-mineral-trioxide-aggregate-versus-calcium-hydroxide
#16
R Kundzina, L Stangvaltaite, H M Eriksen, E Kerosuo
AIM: The aim of this multicentre, parallel-group randomized clinical trial was to compare the effectiveness of mineral trioxide aggregate (MTA) and a conventional calcium hydroxide liner (CH) as direct pulp capping materials in adult molars with carious pulpal exposure. METHODOLOGY: Seventy adults aged 18-55 years were randomly allocated to two parallel arms: MTA (White ProRoot, Dentsply, Tulsa Dental, Tulsa, OK, USA; n = 33) and CH (Dycal(®) , Dentsply DeTrey GmbH, Konstanz, Germany; n = 37)...
November 7, 2016: International Endodontic Journal
https://www.readbyqxmd.com/read/27857514/the-use-of-bioceramics-in-endodontics-literature-review
#17
REVIEW
Stefan Jitaru, Ioana Hodisan, Lucia Timis, Anamaria Lucian, Marius Bud
BACKGROUND AND AIM: Bioceramics are ceramic compounds obtained both in situ and in vivo, by various chemical processes. Bioceramics exhibit excellent biocompatibility due to their similarity with biological materials, like hydroxyapatite. Bioceramics and multi-substituted hydroxyapatite or similar compounds have the ability to induce a regenerative response in the organism. The aim of this paper is to make a literature review on the main bioceramic materials currently used in endodontics and on their specific characteristics...
2016: Clujul Medical (1957)
https://www.readbyqxmd.com/read/27698421/effect-of-an-experimental-direct-pulp-capping-material-on-the-properties-and-osteogenic-differentiation-of-human-dental-pulp-stem-cells
#18
Fan Yu, Yan Dong, Yan-Wei Yang, Ping-Ting Lin, Hao-Han Yu, Xiang Sun, Xue-Fei Sun, Huan Zhou, Li Huang, Ji-Hua Chen
Effective pulp-capping materials must have antibacterial properties and induce dentin bridge formation; however, many current materials do not satisfy clinical requirements. Accordingly, the effects of an experiment pulp-capping material (Exp) composed of an antibacterial resin monomer (MAE-DB) and Portland cement (PC) on the viability, adhesion, migration, and differentiation of human dental pulp stem cells (hDPSCs) were examined. Based on a Cell Counting Kit-8 assay, hDPSCs exposed to Exp extracts showed limited viability at 24 and 48 h, but displayed comparable viability to the control at 72 h...
October 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27659037/role-of-laser-irradiation-in-direct-pulp-capping-procedures-a-systematic-review-and-meta-analysis
#19
REVIEW
Fawad Javed, Sergio Varela Kellesarian, Tariq Abduljabbar, Elham Gholamiazizi, Changyong Feng, Khaled Aldosary, Fahim Vohra, Georgios E Romanos
A variety of materials are available to treat exposed dental pulp by direct pulp capping. The healing response of the pulp is crucial to form a dentin bridge and seal off the exposed pulp. Studies have used lasers to stimulate the exposed pulp to form tertiary dentin. The aim of the present systematic review and meta-analysis was to evaluate the evidence on the effects of laser irradiation as an adjunctive therapy to stimulate healing after pulp exposure. A systematic literature search was conducted up to April 2016...
February 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/27631157/alternative-approach-for-carious-tissue-removal-in-primary-teeth
#20
B Z Mello, T C Stafuzza, L L R Vitor, D Rios, M A Machado, T M Oliveira
BACKGROUND: Minimally-invasive techniques for the management of carious dental tissue has been well documented. This study aimed to report on the clinical and radiographic response after partial caries removal on left mandibular primary second molar. CASE REPORT: A 6-year-old boy sought treatment because of pain in the left mandibular primary second molar. The tooth had a deep caries lesion on the occlusal surface, with loss of enamel structure and dentine proximity with the pulp confirmed by periapical radiograph...
October 2016: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
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