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Guided Tissue Regeneration

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https://www.readbyqxmd.com/read/28534283/cell-type-specific-extracellular-matrix-guided-the-differentiation-of-human-mesenchymal-stem-cells-in-3d-polymeric-scaffolds
#1
Yong Mao, Tyler Hoffman, Amy Wu, Ritu Goyal, Joachim Kohn
The tissue microenvironment has profound effects on tissue-specific regeneration. The 3-dimensional extracellular matrix (ECM) niche influences the linage-specific differentiation of stem cells in tissue. To understand how ECM guides tissue-specific regeneration, we established a series of 3D composite scaffolds containing ECMs derived from different primary cells isolated from a single animal species and assessed their impact on the differentiation of human mesenchymal stem cells (hMSCs). Synthetic microfiber scaffolds (fiber mats) were fabricated by electrospinning tyrosine-derived polycarbonates (pDTEC)...
July 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28529754/chitosan-poly-caprolactone-nanofibers-for-skin-repair
#2
Sheeny Lan Levengood, Ariane E Erickson, Fei-Chien Chang, Miqin Zhang
Dermal wounds, both acute and chronic, represent a significant clinical challenge and therefore the development of novel biomaterial-based skin substitutes to promote skin repair is essential. Nanofibers have garnered attention as materials to promote skin regeneration due to the similarities in morphology and dimensionality between nanofibers and native extracellular matrix proteins, which are critical in guiding cutaneous wound healing. Electrospun chitosan-poly(caprolactone) (CPCL) nanofiber scaffolds, which combine the important intrinsic biological properties of chitosan and the mechanical integrity and stability of PCL, were evaluated as skin tissue engineering scaffolds using a mouse cutaneous excisional skin defect model...
March 7, 2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/28518068/3d-magnetic-stem-cell-aggregation-and-bioreactor-maturation-for-cartilage-regeneration
#3
Aurore Van de Walle, Claire Wilhelm, Nathalie Luciani
Cartilage engineering remains a challenge due to the difficulties in creating an in vitro functional implant similar to the native tissue. An approach recently explored for the development of autologous replacements involves the differentiation of stem cells into chondrocytes. To initiate this chondrogenesis, a degree of compaction of the stem cells is required; hence, we demonstrated the feasibility of magnetically condensing cells, both within thick scaffolds and scaffold-free, using miniaturized magnetic field sources as cell attractors...
April 27, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28516795/a-comprehensive-guide-to-telocytes-and-their-great-potential-in-cardiovascular-system
#4
I Kucybala, P Janas, S Ciuk, W Cholopiak, W Klimek-Piotrowska, M K Holda
Telocytes, a recently discovered type of interstitial cells, have a very distinctive morphology - the small cell body with long extensions, named telopodes. In our review, apart from introducing general aspects of telocytes, we focus on properties, functions and future potential of those cells in cardiovascular system. However, physiological functions of telocytes in cardiovascular system are still regarded as quite enigmatic. Previous studies claim that they play a role in organogenesis and regeneration, bioelectrical signalling, mechanoelectrical coupling, anti-oxidative protection, angiogenesis and regulation of blood flow...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28513544/morphogenetically-active-barrier-membrane-for-guided-bone-regeneration-based-on-amorphous-polyphosphate
#5
Xiaohong Wang, Maximilian Ackermann, Meik Neufurth, Shunfeng Wang, Heinz C Schröder, Werner E G Müller
We describe a novel regeneratively-active barrier membrane which consists of a durable electrospun poly(ε-caprolactone) (PCL) net covered with a morphogenetically-active biohybrid material composed of collagen and inorganic polyphosphate (polyP). The patch-like fibrous collagen structures are decorated with small amorphous polyP nanoparticles (50 nm) formed by precipitation of this energy-rich and enzyme-degradable (alkaline phosphatase) polymer in the presence of calcium ions. The fabricated PCL-polyP/collagen hybrid mats are characterized by advantageous biomechanical properties, such as enhanced flexibility and stretchability with almost unaltered tensile strength of the PCL net...
May 17, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28513477/microtube-array-membrane-bioreactor-promotes-neuronal-differentiation-and-orientation
#6
Sabrina Morelli, Antonella Piscioneri, Simona Salerno, Chien-Chung Chen, Chee Ho Chew, Lidietta Giorno, Enrico Drioli, Loredana De Bartolo
An important challenge in neuronal tissue engineering is to create innovative tools capable of promoting cellular response in terms of neuronal differentiation and neurite orientation that may be used as investigational platforms for studying neurobiological events and neurodegenerative disorders. A novel membrane bioreactor was created to provide a 3D well-controlled microenvironment for neuronal outgrowth. The bioreactor consisted of poly-L-lactic acid highly aligned microtube array (PLLA-MTA) membranes assembled in parallel within a chamber that establish an intraluminal and an extraluminal compartment whose communication occurs through the pores of the MTA membrane walls...
May 17, 2017: Biofabrication
https://www.readbyqxmd.com/read/28509406/high-heparin-content-surface-modified-polyurethane-discs-promote-rapid-and-stable-angiogenesis-in-full-thickness-skin-defects-through-vegf-immobilization
#7
M McLuckie, C A Schmidt, A Oosthuysen, N Sanchez-Macedo, H Merker, D Bezuidenhout, S P Hoerstrup, N Lindenblatt
Three-dimensional scaffolds have the capacity to serve as an architectural framework to guide and promote tissue regeneration. Parameters such as the type of material, growth factors, and pore dimensions are therefore critical in the scaffold's success. In this study, heparin has been covalently bound to the surface of macroporous polyurethane (PU) discs via two different loading methods in order to determine if the amount of heparin content had an influence on the therapeutic affinity loading and release of (VEGF165 ) in full thickness skin defects...
May 16, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28506465/deconstructing-olfactory-stem-cell-trajectories-at-single-cell-resolution
#8
Russell B Fletcher, Diya Das, Levi Gadye, Kelly N Street, Ariane Baudhuin, Allon Wagner, Michael B Cole, Quetzal Flores, Yoon Gi Choi, Nir Yosef, Elizabeth Purdom, Sandrine Dudoit, Davide Risso, John Ngai
A detailed understanding of the paths that stem cells traverse to generate mature progeny is vital for elucidating the mechanisms governing cell fate decisions and tissue homeostasis. Adult stem cells maintain and regenerate multiple mature cell lineages in the olfactory epithelium. Here we integrate single-cell RNA sequencing and robust statistical analyses with in vivo lineage tracing to define a detailed map of the postnatal olfactory epithelium, revealing cell fate potentials and branchpoints in olfactory stem cell lineage trajectories...
April 28, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28485078/tubular-open-porous-%C3%AE-tcp-plcl-scaffolds-as-guiding-structure-for-segmental-bone-defect-regeneration-in-a-novel-sheep-model
#9
Anne-Marie Pobloth, Hanna Schell, Ansgar Petersen, Katleen Beierlein, Christian Kleber, Katharina Schmidt-Bleek, Georg N Duda
Large segmental bone defect reconstruction with sufficient functional restoration is one of the most demanding challenges in orthopedic surgery. Available regenerative treatment options, as the vascularized bone graft transfer, the Masquelet technique or the Ilizarov distraction osteogenesis, are associated with specific indications and distinct limitations. As an alternative, a hollow cylindrical ceramic-polymer composite scaffold (beta-tricalcium phosphate and poly-lactid co-ε- caprolactone), facilitating a strong surface guiding effect for tissue ingrowth (group 1; n = 6) was investigated here...
May 8, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28481635/heterotopic-implantation-of-decellularized-pulmonary-artery-homografts-in-a-rodent-model-technique-description-and-preliminary-report
#10
Arben Dedja, Massimo A Padalino, Mila Della Barbera, Cosimo Rasola, Paola Pesce, Anna Milan, Michela Pozzobon, David Sacerdoti, Gaetano Thiene, Giovanni Stellin
PURPOSE: Despite a substantial amount of literature on tissue-guided regeneration, decellularization process, repopulation time points and stem cell turnover, more in-depth study on the argument is required. Currently, there are plenty of reports involving large animals, as well as clinical studies facing cardiac repair with decellularized homografts, but no exhaustive rodent models are described. The purpose of this study was to develop such a model in rats; preliminary results are also herein reported...
May 8, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28480192/localized-irradiation-of-mouse-legs-using-an-image-guided-robotic-linear-accelerator
#11
Markus Kufeld, Helena Escobar, Andreas Marg, Diana Pasemann, Volker Budach, Simone Spuler
BACKGROUND: To investigate the potential of human satellite cells in muscle regeneration small animal models are useful to evaluate muscle regeneration. To suppress the inherent regeneration ability of the tibialis muscle of mice before transplantation of human muscle fibers, a localized irradiation of the mouse leg should be conducted. We analyzed the feasibility of an image-guided robotic irradiation procedure, a routine treatment method in radiation oncology, for the focal irradiation of mouse legs...
April 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28474968/additive-effect-of-plasma-rich-in-growth-factors-with-guided-tissue-regeneration-in-treatment-of-intrabony-defects-in-chronic-periodontitis-patients-a-split-mouth-randomized-controlled-clinical-trial
#12
Sheethalan Ravi, Sankari Malaiappan, Sheeja Varghese, N D Jayakumar, Gopinath Prakasam
BACKGROUND: Periodontal regeneration can be defined as the complete restoration of lost periodontal tissues to their original architecture and function. Variety of treatment modalities have been proposed to achieve it. Plasma rich in growth factors (PRGF) is a concentrated suspension of growth factors that promotes restoration of the lost periodontal tissues. The objective of the present study was to assess the effect of Plasma rich in growth factors (PRGF) associated with Guided Tissue regeneration (GTR) versus GTR only in the treatment of intrabony defects in chronic periodontitis patients...
May 5, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28467727/a-novel-strategy-to-enhance-secretion-of-ecm-components-by-stem-cells-relevance-to-tissue-engineering
#13
Navaneethakrishnan Krishnamoorthy, Yuan-Tsan Tseng, Poornima Gajendrarao, Padmini Sarathchandra, Ann McCormack, Ivan Carubelli, Jerome Sohier, Najma Latif, Adrian Chester, Magdi H Yacoub
The ability of cells to secrete extracellular matrix (ECM) proteins is an important property in the repair, replacement and regeneration of living tissue. Cells that populate a tissue engineered constructs need to be able to emulate these functions. The motif KTTKS or palmitoyl-KTTKS (peptide amphiphile) have been shown to stimulate the production of collagen and fibronectin in differentiated cells. In here, we described a strategy to enhance the productivity of the peptide through molecular modeling that was used to design different forms of the active peptide motifs KTTKS/SKTTK/SKTTKS connected by various hydrophobic linkers, V<sub>4</sub>A<sub>3</sub>/V<sub>4</sub>A<sub>2</sub>/A<sub>4</sub>G<sub>3</sub>...
May 3, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28466608/guided-bone-regeneration-with-recombinant-human-bone-morphogenetic-protein-9-loaded-on-either-deproteinized-bovine-bone-mineral-or-a-collagen-barrier-membrane
#14
Nikola Saulacic, Masako Fujioka-Kobayashi, Eizaburo Kobayashi, Benoit Schaller, Richard J Miron
BACKGROUND: Recombinant human bone morphogenetic protein 9 (rhBMP9) has been considered the most osteoinductive growth factor of the BMP-family and has much translation potential for guided bone regeneration (GBR) procedures. PURPOSE: The aim of this study was to compare bone formation using rhBMP9 loaded with different carrier systems including deprotenized bovine bone mineral (BioOss, BO) or collagen barrier membranes (BioGide, BG) in a rabbit GBR model. MATERIALS AND METHODS: rhBMP9 was loaded either on BO; named BO/BMP9, or BG; named BG/BMP9 to investigate the better carrier system for rhBMP9...
May 2, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28447671/the-scaffold-microenvironment-for-stem-cell-based-bone-tissue-engineering
#15
REVIEW
Zhichao Hao, Zhenhua Song, Jun Huang, Keqing Huang, Amanda Panetta, Zhipeng Gu, Jun Wu
Bone tissue engineering uses the principles and methods of engineering and life sciences to study bone structure, function and growth mechanism for the purposes of repairing, maintaining and improving damaged bone tissue. Scaffolds not only provide structural support for stem cells in cell adhesion and proliferation and bone formation, but also serve as a microenvironment for guiding stem cell differentiation and tissue regeneration and for controlling tissue structure. This review presents the research status of the scaffold microenvironment for bone-related stem cells based on bone tissue engineering...
April 27, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28445234/safe-new-approach-to-the-lingual-flap-management-in-mandibular-augmentation-procedures-the-digitoclastic-technique
#16
Roberto Pistilli, Vittorio Checchi, Gilberto Sammartino, Massimo Simion, Pietro Felice
PURPOSE: This article describes the digitoclastic technique, an innovative procedure for coronal displacement of the lingual flap. The new technique has the potential to obtain primary flap closure without surgical risks to the anatomical structures on the lingual side of the mandible. MATERIALS AND METHODS: Reconstruction of an atrophic mandible with guided tissue regeneration (guided bone regeneration) and implant placement is described, using the digitoclastic technique to displace the lingual flap coronally...
April 25, 2017: Implant Dentistry
https://www.readbyqxmd.com/read/28415427/surface-physical-chemistry-properties-in-coated-bacterial-cellulose-membranes-with-calcium-phosphate
#17
Gabriel Molina de Olyveira, Pierre Basmaji, Ligia Maria Manzine Costa, Márcio Luiz Dos Santos, Carla Dos Santos Riccardi, Fernando Pozzi Semeghini Guastaldi, Raquel Mantuaneli Scarel-Caminaga, Ticiana Sidorenko de Oliveira Capote, Elisabeth Pizoni, Antônio Carlos Guastaldi
Bacterial cellulose has become established as a new biomaterial, and it can be used for medical applications. In addition, it has called attention due to the increasing interest in tissue engineering materials for wound care. In this work, the bacterial cellulose fermentation process was modified by the addition of chondroitin sulfate to the culture medium before the inoculation of the bacteria. The biomimetic process with heterogeneous calcium phosphate precipitation of biological interest was studied for the guided regeneration purposes on bacterial cellulose...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28407447/hierarchical-micro-nanofibrous-bioscaffolds-for-structural-tissue-regeneration
#18
Yun Xu, Wenguo Cui, Yanxia Zhang, Pinghui Zhou, Yong Gu, Xiaofeng Shen, Bin Li, Liang Chen
Various biomimetic scaffolds with hierarchical micro/nanostructures are designed to closely mimic native extracellular matrix network and to guide cell behavior to promote structural tissue generation. However, it remains a challenge to fabricate hierarchical micro/nanoscaled fibrous scaffolds with different functional components that endow the scaffolds with both biochemical and physical features to exert different biological roles during the process of tissue healing. In this study, a biomimetic designed micro/nanoscaled scaffold with integrated hierarchical dual fibrillar components is fabricated in order to repair dura mater and prevent the formation of epidural scars via collagen molecule self-assembly, electrospinning, and biological interface crosslinking strategies...
April 13, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28402353/peri-implant-soft-tissue-stability-after-single-implant-restorations-using-either-guided-bone-regeneration-or-a-connective-tissue-graft-a-randomized-clinical-trial
#19
Chiara D'Elia, Nicola Baldini, Edoardo Ferrari Cagidiaco, Giacomo Nofri, Cecilia Goracci, Massimo de Sanctis
The purpose of the present study was to compare two different surgical procedures, connective tissue graft and guided bone regeneration, when applied in conjunction with implant placement. Probing pocket depth and the recession depth were recorded at the implant site after crown placement (T₁) and at the 1-year follow-up (T₂), while the keratinized tissue height and the buccal mucosa thickness were recorded at three different time points: at the time of implant surgery (T₀), after crown placement, and at the 1-year follow-up...
May 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28402345/mandibular-regional-anatomical-landmarks-and-clinical-implications-for-ridge-augmentation
#20
Istvan A Urban, Alberto Monje, Hom-Lay Wang, Jaime Lozada, Gabor Gerber, Gabor Baksa
Mandibular ridge augmentation via guided bone regeneration in the atrophic mandible is considered one of the most challenging scenarios for implant-supported oral rehabilitation. Uneventful wound healing has clearly demonstrated its impact on the final regenerative outcome. Soft tissue management must be precise and adequate to attain flap-free wound closure. Accordingly, it demands exhaustive insight and expertise to avoid damaging the neighboring structures. The cadaver study described herein discusses the mandibular morphologic landmarks (ie, musculature, vascularization, innervation, and salivary glands) necessary to safely perform regenerative procedures in the atrophic mandibular ridge, such as vertical ridge augmentation and dental implant surgery...
May 2017: International Journal of Periodontics & Restorative Dentistry
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