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Guided Tissue Regeneration

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https://www.readbyqxmd.com/read/28938030/wound-healing-complications-following-guided-bone-regeneration-for-ridge-augmentation-a-systematic-review-and-meta-analysis
#1
Glendale Lim, Guo-Hao Lin, Alberto Monje, Hsun-Liang Chan, Hom-Lay Wang
PURPOSE: The rate of developing soft tissue complications that accompany guided bone regeneration (GBR) procedures varies widely, from 0% to 45%. The present review was conducted to investigate the rate for resorbable versus nonresorbable membranes and the timing of soft tissue complications. MATERIALS AND METHODS: Electronic and manual literature searches were conducted by two independent reviewers using several databases, including MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and Cochrane Oral Health Group Trials Register, for articles published through July 2015, with no language restriction...
September 22, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28932862/tailored-release-of-triiodothyronine-and-retinoic-acid-from-a-spatio-temporally-fabricated-nanofiber-composite-instigating-neuronal-differentiation
#2
Aishwarya Satish, Purna Sai Korrapati
Regeneration of the central and peripheral nervous system is challenging since the functional restoration of injured nerves is an incredible task. The fabrication of an ideal nerve guide that fulfills the requirement to regenerate nerve tissue is a herculean challenge requiring a combination of both biochemical and topographical cues. The present study explores the combinatorial effect of aligned nanofibers and the regulated delivery of triiodothyronine and retinoic acid on nerve regeneration. A sequential release mechanism is adopted in fabricating the nanofiber scaffold, with triiodothyronine incorporated into the nanofiber shell ensuring its prior release, followed by retinoic acid (entrapped within zein nanoparticles) from the core...
September 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/28927933/azopolymer-photopatterning-for-directional-control-of-angiogenesis
#3
Chiara Fedele, Maria De Gregorio, Paolo A Netti, Silvia Cavalli, Chiara Attanasio
Understanding cellular behavior in response to microenvironmental stimuli is central to tissue engineering. An increasing number of reports emphasize the high sensitivity of cells to the physical characteristics of the surrounding milieu and in particular, topographical cues. In this work, we investigated the influence of dynamic topographic signal presentation on sprout formation and the possibility to obtain a space-time control over sprouting directionality without growth factors, in order to investigate the contribution of just topography in the angiogenic process...
September 16, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28924826/volumetric-and-linear-changes-at-dental-implants-following-grafting-with-volume-stable-three-dimensional-collagen-matrices-or-autogenous-connective-tissue-grafts-6-month-data
#4
Nadja Naenni, Stefan P Bienz, Goran I Benic, Ronald E Jung, Christoph H F Hämmerle, Daniel S Thoma
OBJECTIVES: The objective of this study was to test whether or not soft tissue augmentation with a volume-stable collagen matrix (VCMX) leads to similar volume gain around dental implants compared to autogenous subepithelial connective tissue graft (SCTG). MATERIALS AND METHODS: In 12 adult beagle dogs, immediate implants were placed with simultaneous guided bone regeneration. After 25-45 weeks, soft tissue augmentation was randomly performed using VCMX, SCTG, or a sham-operated control...
September 18, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28922555/laser-micro-ablation-of-fibrocartilage-tissue-effects-of-tissue-processing-on-porosity-modification-and-mechanics
#5
A M Matuska, P S McFetridge
The temporomandibular joint disk (TMJd) is an extremely dense and avascular fibrocartilaginous extracellular matrix (ECM) resulting in a limited regenerative capacity. The use of decellularized TMJd as a biocompatible scaffold to guide tissue regeneration is restricted by innate subcellular porosity of the ECM that hinders cellular infiltration and regenerative events. Incorporation of an artificial microporosity through laser micro-ablation (LMA) can alleviate these cell and diffusion based limitations. In this study, LMA was performed either before or after decellularization to assess to effect of surfactant treatment on porosity modification as well as the resultant mechanical and physical scaffold properties...
September 18, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28914948/nanotopography-mediated-osteogenic-differentiation-of-human-dental-pulp-derived-stem-cells
#6
Akash Bachhuka, Bahman Delalat, Soraya Rasi Ghaemi, Stan Gronthos, Nicolas H Voelcker, Krasimir Vasilev
Advanced medical devices, treatments and therapies demand an understanding of the role of interfacial properties on the cellular response. This is particularly important in the emerging fields of cell therapies and tissue regeneration. In this study, we evaluate the role of surface nanotopography on the fate of human dental pulp derived stem cells (hDPSC). These stem cells have attracted interest because of their capacity to differentiate to a range of useful lineages but are relatively easy to isolate. We generated and utilized density gradients of gold nanoparticles which allowed us to examine, on a single substrate, the influence of nanofeature density and size on stem cell behavior...
September 15, 2017: Nanoscale
https://www.readbyqxmd.com/read/28902637/development-of-fish-collagen-bioactive-glass-chitosan-composite-nanofibers-as-a-gtr-gbr-membrane-for-inducing-periodontal-tissue-regeneration
#7
Tian Zhou, Xin Liu, Baiyan Sui, Chao Liu, Xiumei Mo, Jiao Sun
The development of a guided tissue or bone regeneration (GTR/GBR) membrane with excellent performance has been a major challenge in the biomedical field. The present study was designed to prepare a biomimetic electrospun fish collagen/bioactive glass/chitosan (Col/BG/CS) composite nanofiber membrane and determine its structure, mechanical property, antibacterial activity, and biological effects on human periodontal ligament cells (HPDLCs). The effects of this composite membrane on inducing periodontal tissue regeneration were evaluated using a dog class II furcation defect model...
September 13, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28894753/evaluation-of-epigallocatechin-3-gallate-modified-collagen-membrane-and-concerns-on-schwann-cells
#8
Chenyu Chu, Jia Deng, Cong Cao, Yi Man, Yili Qu
Collagen is an essential component of the extracellular matrix (ECM) and is a suitable material for nerve repair during tissue remodeling for fracture repair. Epigallocatechin-3-gallate (EGCG), an extract of green tea, shows various biological activities that are beneficial to nerve repair. Here, we developed modified collagen containing different concentrations of EGCG (0.0064%, 0.064%, and 0.64%, resp.) to induce Schwann cell proliferation and differentiation. Cell Counting Kit-8 test, live/dead assay, and SEM showed that collagen cross-linked by EGCG induced Schwann cell proliferation...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28893226/effect-of-periodontitis-on-the-development-of-osteoporosis-results-from-a-nationwide-population-based-cohort-study-2003-2013
#9
Jung-Kyu Choi, Young-Taek Kim, Hye-In Kweon, Eun-Cheol Park, Seong-Ho Choi, Jae-Hong Lee
BACKGROUND: The prevalence of osteoporosis associated with the aging process is anticipated to increase along with the rising aging population. Periodontitis that the most common chronic infections of humankind is considered the risk factor for osteoporosis. The aim of this study was to identify the association between osteoporosis and periodontitis using a population-based cohort. METHODS: The case group was defined as patients diagnosed with periodontitis and treated with subgingival curettage, root conditioning, periodontal flap operation, bone grafting for alveolar bone defects, and guided tissue regeneration...
September 11, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28893049/comparative-evaluation-of-the-efficacy-of-bioactive-ceramic-composite-granules-alone-and-in-combination-with-platelet-rich-fibrin-in-the-treatment-of-mandibular-class-ii-furcation-defects-a-clinical-and-radiographic-study
#10
Hima S Lohi, Dilip G Nayak, Ashita S Uppoor
INTRODUCTION: Predictable closure of furcation defects with bone grafts, Guided Tissue Regeneration (GTR) and a combination of the two has remained an elusive goal so far. Hence, evaluation of biomimetic agents as candidate technologies for periodontal regeneration merit due consideration. In this study, Choukroun's Platelet Rich Fibrin (PRF), a second generation platelet concentrate, is combined with bone graft to examine if the addition enhances the therapeutic potential of bone graft in the management of Class II furcation defects...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28885543/3d-printed-microgroove-pattern-driven-generation-of-oriented-ligamentous-architectures
#11
Chan Ho Park, Kyoung-Hwa Kim, Yong-Moo Lee, William V Giannobile, Yang-Jo Seol
Specific orientations of regenerated ligaments are crucially required for mechanoresponsive properties and various biomechanical adaptations, which are the key interplay to support mineralized tissues. Although various 2D platforms or 3D printing systems can guide cellular activities or aligned organizations, it remains a challenge to develop ligament-guided, 3D architectures with the angular controllability for parallel, oblique or perpendicular orientations of cells required for biomechanical support of organs...
September 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28877649/the-effect-of-hypothermic-and-cryogenic-preservation-on-engineered-neural-tissue
#12
Adam George Edward Day, Kulraj Singh Bhangra, Celia Murray-Dunning, Lara Stevanato, James Phillips
This study explored different approaches to preserve Engineered Neural Tissue (EngNT), a stabilised cellular collagen hydrogel containing columns of aligned Schwann cells for nervous system repair. The ability to preserve EngNT without disrupting cellular and extracellular components and structures is important for clinical translation and commercialisation. Stabilised cellular gels and EngNT constructs were preserved under various conditions and cell survival assessed using live/dead microscopy and metabolic assay...
September 6, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28875278/investigation-of-peri-implant-tissue-conditions-and-peri-implant-tissue-stability-in-implants-placed-with-simultaneous-augmentation-procedure-a-3-year-retrospective-follow-up-analysis-of-a-newly-developed-bone-level-implant-system
#13
Jonas Lorenz, Henriette Lerner, Robert A Sader, Shahram Ghanaati
BACKGROUND: Guided bone regeneration (GBR) has been proven to be a reliable therapy to regenerate missing bone in cases of atrophy of the alveolar crest. The aim of the present retrospective analysis was to assess peri-implant tissue conditions and document peri-implant tissue stability in C-Tech implants when placed simultaneously with a GBR augmentation procedure. METHODS: A total of 47 implants, which were placed simultaneously with a GBR procedure with a synthetic bone substitute material in 20 patients, were investigated clinically and radiologically at least 3 years after loading...
September 5, 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28872501/effects-of-different-tissue-adhesives-in-treating-calvarial-bone-defects
#14
Akif Türer, Mehmet Emin Önger
The purpose of this study is to investigate the potential of the 2 different tissue adhesive materials as a barrier for guided bone regeneration and to compare them with resorbable collogen membrane on autogenous grafted critical-sized cortical bone defects. Twenty-four rats were divided into 3 groups: Group M, Group G, and Group B. A 5-mm diameter critical-size defect was created in the calvarium of each animal. All defects were filled by autogenous graft harvested from tibia. In group M, resorbable collogen membrane was applied to defect area...
September 1, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28866225/fabrication-and-characterization-of-two-layered-nanofibrous-membrane-for-guided-bone-and-tissue-regeneration-application
#15
Maryam Masoudi Rad, Saied Nouri Khorasani, Laleh Ghasemi-Mobarakeh, Molamma P Prabhakaran, Mohammad Reza Foroughi, Mahshid Kharaziha, Niloufar Saadatkish, Seeram Ramakrishna
Membranes used in dentistry act as a barrier to prevent invasion of intruder cells to defected area and obtains spaces that are to be subsequently filled with new bone and provide required bone volume for implant therapy when there is insufficient volume of healthy bone at implant site. In this study a two-layered bioactive membrane were fabricated by electrospinning whereas one layer provides guided bone regeneration (GBR) and fabricated using poly glycerol sebacate (PGS)/polycaprolactone (PCL) and Beta tri-calcium phosphate (β-TCP) (5, 10 and 15%) and another one containing PCL/PGS and chitosan acts as guided tissue regeneration (GTR)...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28866191/nanosized-cap-silk-fibroin-pcl-peg-pcl-pcl-based-bilayer-membranes-for-guided-bone-regeneration
#16
Sibel Türkkan, A Engin Pazarçeviren, Dilek Keskin, Nesrin E Machin, Özgür Duygulu, Ayşen Tezcaner
Guided bone regeneration (GBR) concept has been developed to prevent the formation of non-functional scar tissue layer on defect site by undertaking barrier role. In this study, a new bilayer membrane which consisted of one layer of electrospun silk fibroin/PCL-PEG-PCL incorporating nanocalcium phosphate (SPCA)(1) and one layer of PCL membrane was developed for GBR. To improve the osteoconductivity of membranes, nanosized calcium phosphate particles synthesized by Flame Spray Pyrolysis method were incorporated into membranes at 10% (wt) (SPCA10) and 20% (wt) (SPCA20) of the polymer content...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28866160/diatomite-reinforced-chitosan-composite-membrane-as-potential-scaffold-for-guided-bone-regeneration
#17
Sedef Tamburaci, Funda Tihminlioglu
In this study, natural silica source, diatomite, incorporated novel chitosan based composite membranes were fabricated and characterized for bone tissue engineering applications as possible bone regeneration membrane. The effect of diatomite loading on the mechanical, morphological, chemical, thermal and surface properties, wettability and in vitro cytotoxicity and cell proliferation on of composite membranes were investigated and observed by tensile test, atomic force microscopy (AFM), Fourier transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TGA), protein adsorption assay, air/water contact angle analysis and WST-1 respectively...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28865805/de-novo-root-regeneration-from-leaf-explants-wounding-auxin-and-cell-fate-transition
#18
REVIEW
Lin Xu
Root organogenesis after tissue damage is a type of plant regeneration known as de novo root regeneration (DNRR). The DNRR process is widely exploited in agricultural technologies, such as cuttings for vegetative propagation. This review summarizes recent advances in our understanding of the cellular and molecular framework of DNRR, mainly focusing on rooting from Arabidopsis thaliana leaf explants. The framework comprises three successive phases, that is, early signaling, auxin accumulation, and cell fate transition, and involves two types of cells with different functions: the converter cell that converts the early signals as the input into auxin flux as the output; and the regeneration-competent cell that undergoes fate transition guided by auxin...
August 30, 2017: Current Opinion in Plant Biology
https://www.readbyqxmd.com/read/28862689/the-efficacy-of-electron-beam-irradiated-bacterial-cellulose-membranes-as-compared-with-collagen-membranes-on-guided-bone-regeneration-in-peri-implant-bone-defects
#19
So-Hyoun Lee, Sung-Jun An, Youn-Mook Lim, Jung-Bo Huh
Bacterial cellulose (BC) is a natural polysaccharide produced by some bacteria, and consists of a linear polymer linked by β-(1,4) glycosidic bonds. BC has been developed as a material for tissue regeneration purposes. This study was conducted to evaluate the efficacy of resorbable electron beam irradiated BC membranes (EI-BCMs) for guided bone regeneration (GBR). The electron beam irradiation (EI) was introduced to control the biodegradability of BC for dental applications. EI-BCMs had higher porosity than collagen membranes (CMs), and had similar wet tensile strengths to CMs...
September 1, 2017: Materials
https://www.readbyqxmd.com/read/28844964/regenerating-bone-with-bioactive-glass-scaffolds-a-review-of-in-vivo-studies-in-bone-defect-models
#20
REVIEW
Aiah A El-Rashidy, Judith A Roether, Leila Harhaus, Ulrich Kneser, Aldo R Boccaccini
Large bone defects resulting from fractures and disease are a medical concern, being often unable to heal spontaneously by the body's repair mechanisms. Bone tissue engineering (BTE) is a promising approach for treating bone defects through providing a template to guide osseous regeneration. 3D scaffolds with microstructure mimicking host bone are necessary in common BTE strategies. Bioactive glasses (BGs) attract researchers' attention as BTE scaffolds as they are osteoconductive and osteoinductive in certain formulations...
August 24, 2017: Acta Biomaterialia
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