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Guided Tissue Regeneration

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https://www.readbyqxmd.com/read/27914325/fabrication-of-metronidazole-loaded-poly-%C3%AE%C2%B5-caprolactone-zein-core-shell-nanofiber-membranes-via-coaxial-electrospinning-for-guided-tissue-regeneration
#1
Min He, Huiyi Jiang, Rui Wang, Yi Xie, Changsheng Zhao
To develop a biologically mimetic guided tissue regeneration (GTR) membrane with localized sustained drug release function to prevent infection, coaxial electrospinning technique was conducted to fabricate metronidazole (MNA)-loaded poly (ε-caprolactone) (PCL)/zein core/shell nanofibers. The nanofibers displayed a uniform bead-free round morphology as observed by scanning electron microscopy (SEM), and a core/shell structure as confirmed by transmission electron microscopy (TEM). X-ray diffraction (XRD) and differential scanning calorimetry (DSC) characterizations demonstrated that the MNA was well dispersed in the nanofibers matrix...
November 19, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27910815/in-vitro-and-in-vivo-evaluations-of-a-novel-post-electrospinning-treatment-to-improve-the-fibrous-structure-of-chitosan-membranes-for-guided-bone-regeneration
#2
Hengjie Su, Kwei-Yu Liu, Anastasios Karydis, Daniel G Abebe, Chaoxi Wu, Kenneth M Anderson, Najib Ghadri, Pradeep Adatrow, Tomoko Fujiwara, Joel D Bumgardner
Electrospun chitosan membranes have been investigated for guided bone regeneration but are susceptible to swelling, dissolution, and loss of biomimetic nanofiber structure due to residual acid salts. A novel process was investigated for acidic salt removal from chitosan electrospun in 70% trifluoroacetic acid (TFA) by treating with triethylamine (TEA)/acetone and di-tert-butyl dicarbonate (tBOC) instead of the common Na2CO3 treatment. TFA salt removal and nanofiber structure stabilization were confirmed by EDS, FTIR, (19)F NMR and electron microscopy before and after soaking in water...
December 2, 2016: Biomedical Materials
https://www.readbyqxmd.com/read/27886664/degradation-behaviors-of-geometric-cues-and-mechanical-properties-in-a-3d-scaffold-for-tendon-repair
#3
Yang Wu, Yoke San Wong, Jerry Ying Hsi Fuh
A three-dimensional (3D) scaffold fabricated via electrohydrodynamic jet printing (E-jetting) and thermally uniaxial stretching, has been developed for tendon tissue regeneration in our previous study. In this study, more in-depth biological test showed that the aligned cell morphology guided by the anisotropic geometries of the 3D tendon scaffolds, leading to up-regulated tendious gene expression including collagen type I, decorin, tenascin-C and biglycan, as compared to the electrospun scaffolds. Given the importance of geometric cues to the biological function of the scaffolds, the degradation behaviors of the 3D scaffolds were investigated...
November 25, 2016: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27882438/histochemical-examination-of-systemic-administration-of-eldecalcitol-combined-with-guided-bone-regeneration-for-bone-defect-restoration-in-rats
#4
Xiuchun Han, Juan Du, Di Liu, Hongrui Liu, Norio Amizuka, Minqi Li
The aim of this experiment was to elucidate the histological alterations after systemic administration of eldecalcitol (ELD) combined with guided bone regeneration during the restoration of bone defect healing in rats. The femurs of 8-week-old Wister rats were used to generate bone defect models. The defect was covered with a collagen membrane, and ELD group was administrated with eldecalcitol (50 ng/kg body weight) intragastrically once every other day. Femora were harvested at 1, 2, 4 and 8 weeks post-surgery...
November 23, 2016: Journal of Molecular Histology
https://www.readbyqxmd.com/read/27882267/microvesicles-as-vehicles-for-tissue-regeneration-changing-of-the-guards
#5
REVIEW
Nikolaos Panagiotou, R Wayne Davies, Colin Selman, Paul G Shiels
PURPOSE OF REVIEW: Microvesicles (MVs) have been recognised as mediators of stem cell function, enabling and guiding their regenerative effects. RECENT FINDINGS: MVs constitute one unique size class of extracellular vesicles (EVs) directly shed from the cell plasma membrane. They facilitate cell-to-cell communication via intercellular transfer of proteins, mRNA and microRNA (miRNA). MVs derived from stem cells, or stem cell regulatory cell types, have proven roles in tissue regeneration and repair processes...
2016: Current Pathobiology Reports
https://www.readbyqxmd.com/read/27865767/neural-stem-cells-promote-nerve-regeneration-through-il12-induced-schwann-cell-differentiation
#6
Don-Ching Lee, Jong-Hang Chen, Tai-Yu Hsu, Li-Hsun Chang, Hsu Chang, Ya-Hui Chi, Ing-Ming Chiu
Regeneration of injured peripheral nerves is a slow, complicated process that could be improved by implantation of neural stem cells (NSCs) or nerve conduit. Implantation of NSCs along with conduits promotes the regeneration of damaged nerve, likely because (i) conduit supports and guides axonal growth from one nerve stump to the other, while preventing fibrous tissue ingrowth and retaining neurotrophic factors; and (ii) implanted NSCs differentiate into Schwann cells and maintain a growth factor enriched microenvironment, which promotes nerve regeneration...
November 16, 2016: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/27857817/conservative-socket-regeneration-with-buccal-wall-defect-using-guided-tissue
#7
Mohammed Jasim Al-Juboori
Progressive alveolar bone resorption after tooth extraction may lead to surgical and prosthetic-driven difficulties, especially when deciding to use a dental implant to replace the extracted tooth. This case report discusses an irreparable lower left second premolar tooth with a periodontal lesion on the buccal side. A preservative tooth extraction was performed. Then, the socket was grafted with bovine bone, a collagen membrane was placed between the buccal bone and the attached gingiva, covering the bone dehiscence buccally, and the socket without a flap was raised...
2016: Open Dentistry Journal
https://www.readbyqxmd.com/read/27847815/comparison-of-bone-resorption-rates-after-intraoral-block-bone-and-guided-bone-regeneration-augmentation-for-the-reconstruction-of-horizontally-deficient-maxillary-alveolar-ridges
#8
B Alper Gultekin, Elcin Bedeloglu, T Emre Kose, Eitan Mijiritsky
Purpose. Bone atrophy after tooth loss may leave insufficient bone for implant placement. We compared volumetric changes after autogenous ramus block bone grafting (RBG) or guided bone regeneration (GBR) in horizontally deficient maxilla before implant placement. Materials and Methods. In this retrospective study, volumetric changes at RBG or GBR graft sites were evaluated using cone-beam computed tomography. The primary outcome variable was the volumetric resorption rate. Secondary outcomes were bone gain, graft success, and implant insertion torque...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27843709/a-computational-model-of-cellular-engraftment-on-lung-scaffolds
#9
Joshua J Pothen, Vignesh Rajendran, Darcy Wagner, Daniel J Weiss, Bradford J Smith, Baoshun Ma, Jason H T Bates
The possibility that stem cells might be used to regenerate tissue is now being investigated for a variety of organs, but these investigations are still essentially exploratory and have few predictive tools available to guide experimentation. We propose, in this study, that the field of lung tissue regeneration might be better served by predictive tools that treat stem cells as agents that obey certain rules of behavior governed by both their phenotype and their environment. Sufficient knowledge of these rules of behavior would then, in principle, allow lung tissue development to be simulated computationally...
2016: BioResearch Open Access
https://www.readbyqxmd.com/read/27842886/potential-of-electrospun-chitosan-fibers-as-a-surface-layer-in-functionally-graded-gtr-membrane-for-periodontal-regeneration
#10
Saad B Qasim, Shariq Najeeb, Robin M Delaine-Smith, Andrew Rawlinson, Ihtesham Ur Rehman
OBJECTIVE: The regeneration of periodontal tissues lost as a consequence of destructive periodontal disease remains a challenge for clinicians. Guided tissue regeneration (GTR) has emerged as the most widely practiced regenerative procedure. Aim of this study was to electrospin chitosan (CH) membranes with a low or high degree of fiber orientation and examines their suitability for use as a surface layer in GTR membranes, which can ease integration with the periodontal tissue by controlling the direction of cell growth...
November 11, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/27834419/limitations-and-options-using-resorbable-versus-nonresorbable-membranes-for-successful-guided-bone-regeneration
#11
Nikolaos K Soldatos, Popi Stylianou, Vasiliki P Koidou, Nikola Angelov, Raymond Yukna, Georgios E Romanos
OBJECTIVE: Deficient bony ridges often complicate the implant treatment plan. Several treatment modalities are used to regenerate bone, including guided bone regeneration (GBR). The purpose of this study was to summarize the knowledge on different types of membranes available and currently used in GBR procedures in a staged approach or with simultaneous implant placement. The primary role of the membranes is to exclude epithelial and connective tissue cells from the wound area to be regenerated, and to create and maintain the space into which pluripotential and osteogenic cells are free to migrate...
November 10, 2016: Quintessence International
https://www.readbyqxmd.com/read/27833336/sub-periosteal-dissection-with-denture-guided-epithelial-regeneration-a-novel-method-for-peri-implant-soft-tissue-management-in-reconstructed-mandibles
#12
Vinay V Kumar, P C Jacob, Moni A Kuriakose
BACKGROUND: In patients with reconstructed mandibles using free fibula flaps, management of soft tissues around implants supporting dental rehabilitation, is often a clinical problem. AIM: The aim of this paper is to describe a new technique, namely "Sub-periosteal dissection and denture-guided epithelial regeneration (SD-DGER)", as a method of peri-implant soft tissue management in these patients. MATERIALS AND METHODS: The technique consists of performing a subperiosteal dissection with creation of buccal and lingual flaps...
December 2016: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/27821905/combined-effects-of-drugs-and-plasticizers-on-the-properties-of-drug-delivery-films
#13
Cheryl L Jennings, Thomas D Dziubla, David A Puleo
Formation of scar tissue may be reduced or prevented if wounds were locally treated with a combination of molecules tuned to the different healing phases, guiding tissue regeneration along a scar free path. To this end, drug delivery devices made of cellulose acetate phthalate and Pluronic F-127 were loaded with either quercetin or pirfenidone and plasticized with either triethyl citrate (TEC) or tributyl citrate (TBC). Quercetin inhibits oxidative stress, and pirfenidone has been shown to reduce production of pro-inflammatory and fibrogenic molecules...
July 2016: Journal of Bioactive and Compatible Polymers
https://www.readbyqxmd.com/read/27806676/the-role-of-cell-seeding-bio-scaffolds-and-the-in-vivo-microenvironment-in-the-guided-generation-of-osteochondral-composite-tissue
#14
Jiao Wei, Tanja Herrler, Kai Liu, Dong Han, Mei Yang, Chuanchang Dai, Qing Feng Li
Tissue engineering based on cell seeding, bio-scaffolds, and growth factors has been widely applied for the reconstruction of tissue defects. Recent progress has fueled in vivo tissue engineering techniques in becoming hot topics in regenerative medicine and reconstructive surgery. To improve the efficacy of tissue engineering, we here investigated the roles of cell seeding, bio-scaffolds, growth factors, and in-vivo microenvironment in tissue regeneration. Bone marrow derived stem cells (BMSCs), allogenic demineralized bone matrix (DBM) as bio-scaffold, and growth factors bone morphogenetic protein 2/ transforming growth factor (BMP-2/TGF-β1), and the in-vivo microenvironment of rib periosteum and perichondrium were used in different combinations for the generation of osteochondral composite tissue...
November 2, 2016: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/27800213/the-influence-of-root-surface-distance-to-alveolar-bone-and-periodontal-ligament-on-periodontal-wound-healing
#15
Marco Montevecchi, Annapaola Parrilli, Milena Fini, Maria Rosaria Gatto, Aurelio Muttini, Luigi Checchi
PURPOSE: The purpose of this animal study was to perform a 3-dimensional micro-computed tomography (micro-CT) analysis in order to investigate the influence of root surface distance to the alveolar bone and the periodontal ligament on periodontal wound healing after a guided tissue regeneration (GTR) procedure. METHODS: Three adult Sus scrofa domesticus specimens were used. The study sample included 6 teeth, corresponding to 2 third mandibular incisors from each animal...
October 2016: Journal of Periodontal & Implant Science
https://www.readbyqxmd.com/read/27798657/the-met-receptor-tyrosine-kinase-confers-repair-of-murine-pancreatic-acinar-cells-following-acute-and-chronic-injury
#16
Ivana Gaziova, Daniel Jackson, Paul J Boor, Dwayne Carter, Zobeida Cruz-Monserrate, Cornelis J Elferink, Aditya D Joshi, Bhupendra Kaphalia, Craig D Logsdon, Karen Pereira de Castro, Lynn Soong, Xinrong Tao, Suimin Qiu, Lisa A Elferink
Acinar cells represent the primary target in necroinflammatory diseases of the pancreas, including pancreatitis. The signaling pathways guiding acinar cell repair and regeneration following injury remain poorly understood. The purpose of this study was to determine the importance of Hepatocyte Growth Factor Receptor/MET signaling as an intrinsic repair mechanism for acinar cells following acute damage and chronic alcohol-associated injury. Here, we generated mice with targeted deletion of MET in adult acinar cells (MET-/-)...
2016: PloS One
https://www.readbyqxmd.com/read/27796463/defining-the-properties-of-an-array-of-nh2-modified-substrates-for-the-induction-of-a-mature-osteoblast-osteocyte-phenotype-from-a-primary-human-osteoblast-population-using-controlled-nanotopography-and-surface-chemistry
#17
Sandra A Fawcett, Judith M Curran, Rui Chen, Nicholas P Rhodes, Mark F Murphy, Peter Wilson, Lakshminarayan Ranganath, Jane P Dillon, James A Gallagher, John A Hunt
Accelerating the integration of a joint replacement or the healing of a bone fracture, particularly a complicated non-union fracture, would improve patient welfare and decrease healthcare costs. Currently, an autologous bone graft is the gold standard method for the treatment of complicated non-union fractures, but it is not always possible to harvest such a graft. A proactive highly inductive so-called smart material approach is pertinent in these cases. In this study, the surface chemistry of a previously approved material with desirable bulk material properties was modified to investigate its potential as an economical and effective alternative...
October 28, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27790620/immune-modulation-of-cardiac-repair-and-regeneration-the-art-of-mending-broken-hearts
#18
REVIEW
Ivana Zlatanova, Cristina Pinto, Jean-Sébastien Silvestre
The accumulation of immune cells is among the earliest responses that manifest in the cardiac tissue after injury. Both innate and adaptive immunity coordinate distinct and mutually non-exclusive events governing cardiac repair, including elimination of the cellular debris, compensatory growth of the remaining cardiac tissue, activation of resident or circulating precursor cells, quantitative and qualitative modifications of the vascular network, and formation of a fibrotic scar. The present review summarizes the mounting evidence suggesting that the inflammatory response also guides the regenerative process following cardiac damage...
2016: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27790579/pure-titanium-membrane-ultra-ti-%C3%A2-in-the-treatment-of-periodontal-osseous-defects-a-split-mouth-comparative-study
#19
Rashmi Khanna, Rajeev Khanna, Nilesh Dinesh Pardhe, Nancy Srivastava, Manas Bajpai, Shailendra Gupta
INTRODUCTION: Although many different types of Guided Tissue Regeneration (GTR) membranes (resorbable/non-resorbable, including titanium mesh) have been used in the field of Periodontics till now, but this is the first and only clinical study testing the effectiveness of an ultra thin pure Titanium Membrane (Ultra Ti) as a GTR membrane in infra-bony periodontal defects. AIM: To compare the efficacy of GTR in intra-bony defects with newly introduced non-resorbable barrier membrane, made of titanium called "Ultra-Ti (®) GTR Membrane" versus open flap debridement...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27788900/rehabilitation-considerations-in-regenerative-medicine
#20
REVIEW
Penny L Head
Rehabilitation and regenerative medicine therapies has shown improved outcomes for tissue regeneration. Regenerative rehabilitation guides protocols regarding when to start therapy, types of stimuli administered, and graded exercise programs, taking into account biological factors and technologies designed to optimize healing potential. Although there are currently no evidence-based guidelines for rehabilitation, fundamental physical therapy principles likely apply. Immobilization tends to have deleterious effects on musculoskeletal tissues; mechanical loading promotes tissue healing and regeneration...
November 2016: Physical Medicine and Rehabilitation Clinics of North America
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