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Guided Tissue Regeneration

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https://www.readbyqxmd.com/read/29791009/withdrawn-interventions-for-replacing-missing-teeth-1-versus-2-stage-implant-placement
#1
REVIEW
Marco Esposito, Maria Gabriella Grusovin, Yun Shane Chew, Paul Coulthard, Helen V Worthington
BACKGROUND: Implants may be placed penetrating the oral mucosa (1-stage procedure) or can be completely buried under the oral mucosa (2-stage procedure) during the healing phase of the bone at the implant surface. With a 2-stage procedure the risk of having unwanted loading onto the implants is minimized, but a second minor surgical intervention is needed to connect the healing abutments and more time is needed prior to start the prosthetic phase because of the wound-healing period required in relation to the second surgical intervention...
May 23, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29781768/guided-bone-regeneration-and-implant-placement-in-association-with-a-coronally-positioned-palatal-sliding-flap-a-17-year-follow-up-case-report
#2
Carlo Maiorana, Pier Paolo Poli, Mario Beretta
The aim of the present case report was to show the 17-year hard and soft tissues stability of guided bone regeneration procedure associated with dental implants insertion. A 52-year-old male patient presented with a partial edentulism in the upper right maxilla. A graft consisting of deproteinized bovine bone mineral and autogenous bone stabilized by a non-resorbable expanded polytetrafluoroethylene membrane was used to reconstruct the missing bone applying the biological principles of guided bone regeneration...
May 21, 2018: Journal of Oral Implantology
https://www.readbyqxmd.com/read/29780613/schwann-cell-durotaxis-can-be-guided-by-physiologically-relevant-stiffness-gradients
#3
Elisabeth B Evans, Samantha W Brady, Anubhav Tripathi, Diane Hoffman-Kim
Background: Successful nerve regeneration depends upon directed migration of morphologically specialized repair state Schwann cells across a nerve defect. Although several groups have studied directed migration of Schwann cells in response to chemical or topographic cues, the current understanding of how the mechanical environment influences migration remains largely understudied and incomplete. Therefore, the focus of this study was to evaluate Schwann cell migration and morphodynamics in the presence of stiffness gradients, which revealed that Schwann cells can follow extracellular gradients of increasing stiffness, in a form of directed migration termed durotaxis...
2018: Biomaterials Research
https://www.readbyqxmd.com/read/29779269/-the-applications-of-periodontal-gingival-surgery-%C3%A2-alternative-materials
#4
Er-Jia Mao
The main purposes of periodontal graft surgery include achieving root coverage, improving the clinical attachment level and keratinized tissue, and advancing the procedure of periodontal plastic surgery. Autogenous graft, such as subepithelial connective tissue graft-based procedure, provide the best outcomes for mean and complete root coverage, as well as increase in keratinized tissue. However, a disadvantage of the procedure is in the location of the operation itself: the additional surgical site (palate)...
April 1, 2018: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/29771148/prospective-randomized-trial-of-electrolysis-for-chronic-plantar-heel-pain
#5
Tomás Fernández-Rodríguez, Álvaro Fernández-Rolle, Sebastián Truyols-Domínguez, Jose C Benítez-Martínez, Jose Casaña-Granell
BACKGROUND: Chronic plantar heel pain (CPHP) is a common condition with high prevalence rates and a projected cost of treatment of US$192 to US$376 million. There are several therapeutic approaches and there is increased interest in treatments aimed at the regeneration of tissues with poor healing potential. Our purpose was to investigate the effectiveness of ultrasound-guided percutaneous needle electrolysis in chronic plantar heel pain. METHODS: A total of 73 patients with a clinical and ultrasonographic diagnosis of plantar heel pain unrelated to systemic inflammatory disease who had not received any other treatment in the previous 6 months on the affected foot were randomly allocated to receive either ultrasound-guided percutaneous needle electrolysis of the fascia (experimental group, n = 39) or placebo puncture (control group, n = 34)...
May 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29769665/bioengineering-strategies-to-accelerate-stem-cell-therapeutics
#6
REVIEW
Christopher M Madl, Sarah C Heilshorn, Helen M Blau
Although only a few stem cell-based therapies are currently available to patients, stem cells hold tremendous regenerative potential, and several exciting clinical applications are on the horizon. Biomaterials with tuneable mechanical and biochemical properties can preserve stem cell function in culture, enhance survival of transplanted cells and guide tissue regeneration. Rapid progress with three-dimensional hydrogel culture platforms provides the opportunity to grow patient-specific organoids, and has led to the discovery of drugs that stimulate endogenous tissue-specific stem cells and enabled screens for drugs to treat disease...
May 2018: Nature
https://www.readbyqxmd.com/read/29762186/decision-making-for-management-of-periimplant-diseases
#7
Khaled Sinjab, Carlos Garaicoa-Pazmino, Hom-Lay Wang
INTRODUCTION: Nonsurgical and surgical management of periimplant mucositis and periimplantitis have shown promising results in arresting periimplant marginal bone loss (MBL) and preventing implant loss. However, management of periimplant diseases still remains unpredictable for full reconstruction of lost tissues and completely arrests disease progression. The present study proposes a decision tree that compiles both clinical and radiographic presentation of failing implants to aid in the decision making for their management...
May 11, 2018: Implant Dentistry
https://www.readbyqxmd.com/read/29757611/simple-synthetic-molecular-hydrogels-from-self-assembling-alkylgalactonamides-as-scaffold-for-3d-neuronal-cell-growth
#8
Anaïs Chalard, Laurence Vaysse, Pierre Joseph, Laurent Malaquin, Sandrine Souleille, Barbara Lonetti, Jean-Christophe Sol, Isabelle Loubinoux, Juliette Fitremann
In this work, we demonstrated that the hydrogel obtained from a very simple and single synthetic molecule, N-heptyl-galactonamide was a suitable scaffold for the growth of neuronal cells in 3D. We evidenced by confocal microscopy the presence of the cells into the gel up to a depth of around 200 μm, demonstrating that the latter was permissive to cell growth and enabled a true 3D colonization and organization. It also supported successfully the differentiation of adult human neuronal stem cells (hNSCs) into both glial and neuronal cells and the development of a really dense neurofilament network...
May 14, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29752108/surface-decorated-hydroxyapatite-scaffold-with-on-demand-delivery-of-dexamethasone-and-stromal-cell-derived-factor-1-for-enhanced-osteogenesis
#9
Bingjun Zhang, Hongyu Li, Lei He, Zhiwei Han, Teng Zhou, Wei Zhi, Xiaobo Lu, Xiong Lu, Jie Weng
In the process of bone regeneration, relatively early biological events including inflammatory response, angiogenesis, or stem cell homing, help the accompanying target actions of cell differentiation and calcification. Herein, we proposed a novel cell-guided tissue engineering system based on a surface-functionalized porous hydroxyapatite (HA) scaffolds with the ability to recruit cells and accelerate the differentiation of them along the osteoblastic lineage for optimizing large-sized bone defect repair. Inspired by microstructural properties of natural bone, HA scaffolds similar to the trabecular bone structure were prepared via a sugar sphere leaching technique, in which the inter-pore opening size was controllable...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29752092/a-novel-porous-bioceramic-scaffold-by-accumulating-hydroxyapatite-spheres-for-large-bone-tissue-engineering-iii-characterization-of-porous-structure
#10
Jingwei Zhang, Dongqin Xiao, Xu He, Feng Shi, Pinfeng Luo, Wei Zhi, Ke Duan, Jie Weng
Physical characteristics of bone tissue engineering scaffolds, including interconnectivity, microporosity, macroporosity, and pore geometry are known to play a crucial role in bone regeneration. In the present study, three-dimensional (3D) interconnected scaffolds were prepared by accumulating hydroxyapatite (HA) spheres in a titanium mesh tube (ф 1.5 × 3 cm). Three types of porous scaffolds were constructed using HA spheres with diameters of 1651-1981 μm, 830-1180 μm and a mixture of 1651-1981 μm and 830-1180 μm at a volumetric ratio of 1:1, respectively...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29747053/use-of-acellular-collagen-matrix-for-the-closure-of-the-open-oral-wound-in-bone-regeneration
#11
Dragan Stankovic, Milica Labudovic-Borovic, Radoslav Radosavljevic, Milos Marinkovic, Esma R Isenovic
Mucograft is collagen matrix was designed for use in open healing situations due to its compact outer layer. The technique presented in this article is an attempt to avail this attribute for covering open oral wound in guided bone regeneration (GBR) procedure. The essential idea of this technique is to avoid scoring of periosteum, submucosa and muscle layer for buccal flap advancement. Therefore, we used mucograft to cover bone substitute and barrier membrane in GBR surgical procedure. Thus, we avoided periostal-releasing incisions (PRI) and gained reposition of the flap to original level without impairing the attached keratinized gingiva...
May 7, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29743347/computational-modeling-guides-tissue-engineered-heart-valve-design-for-long-term-in-vivo-performance-in-a-translational-sheep-model
#12
Maximilian Y Emmert, Boris A Schmitt, Sandra Loerakker, Bart Sanders, Hendrik Spriestersbach, Emanuela S Fioretta, Leon Bruder, Kerstin Brakmann, Sarah E Motta, Valentina Lintas, Petra E Dijkman, Laura Frese, Felix Berger, Frank P T Baaijens, Simon P Hoerstrup
Valvular heart disease is a major cause of morbidity and mortality worldwide. Current heart valve prostheses have considerable clinical limitations due to their artificial, nonliving nature without regenerative capacity. To overcome these limitations, heart valve tissue engineering (TE) aiming to develop living, native-like heart valves with self-repair, remodeling, and regeneration capacity has been suggested as next-generation technology. A major roadblock to clinically relevant, safe, and robust TE solutions has been the high complexity and variability inherent to bioengineering approaches that rely on cell-driven tissue remodeling...
May 9, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29742256/evaluation-of-photobiomodulation-therapy-associated-with-guided-bone-regeneration-in-critical-size-defects-in-vivo-study
#13
Nicole Rosa de Freitas, Luísa Belluco Guerrini, Luis Augusto Esper, Michyele Cristhiane Sbrana, Gisele da Silva Dalben, Simone Soares, Ana Lúcia Pompéia Fraga de Almeida
The repair of bone defects raises the interest of investigators in several health specialties. Grafting techniques with bone substitutes and laser therapies have been investigated to replace autogenous bone and accelerate the bone healing process. Objective To evaluate the effect of photobiomodulation therapy (PBMT) associated with guided bone regeneration (GBR) in critical size defects. Material and Methods The study was conducted on 80 male rats (Rattus norvegicus albinus, Wistar) submitted to surgical creation of a critical size defect on the calvaria, divided into eight study groups: group C (control - only blood clot); group M (collagen membrane); group PBMT (photobiomodulation therapy); group AB (autogenous bone); group AB+PBMT; group AB+M; group PBMT+M; group AB+PBMT+M...
2018: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29741115/the-role-of-biomaterials-in-implantation-for-central-nervous-system-injury
#14
Yu-Shuan Chen, Horng-Jyh Harn, Tzyy-Wen Chiou
Permanent deficits that occur in memory, sensation, and cognition can result from central nervous system (CNS) trauma that causes dysfunction and/or unregulated CNS regeneration. Some therapeutic approaches are preferentially applied to the human body. Therefore, cell transplantation, one of the therapeutic strategies, may be used to benefit people. However, poor cell viability and low efficacy are the limitations to cell transplantation strategies. Biomaterials have been widely used in several fields (e.g...
January 1, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29740965/comparative-evaluation-of-chitosan-nerve-guides-with-regular-or-increased-bendability-for-acute-and-delayed-peripheral-nerve-repair-a-comprehensive-comparison-with-autologous-nerve-grafts-and-muscle-in-vein-grafts
#15
Maria Stößel, Vivien M Wildhagen, Olaf Helmecke, Jennifer Metzen, Charlotte B Pfund, Thomas Freier, Kirsten Haastert-Talini
Reconstruction of joint-crossing digital nerves requires the application of nerve guides with a much higher flexibility than used for peripheral nerve repair along larger bones. Nevertheless, collapse-resistance should be preserved to avoid secondary damage to the regrowing nerve tissue. In recent years, we presented chitosan nerve guides (CNGs) to be highly supportive for the regeneration of critical gap length peripheral nerve defects in the rat. Now, we evidently increased the bendability of regular CNGs (regCNGs) by developing a wavy wall structure, that is, corrugated CNGs (corrCNGs)...
May 8, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29738457/in-vitro-comparative-study-of-oxygen-plasma-treated-poly-lactic%C3%A2-co%C3%A2-glycolic-plga-membranes-and-supported-nanostructured-oxides-for-guided-bone-regeneration-processes
#16
Daniel Torres-Lagares, Lizett Castellanos-Cosano, Maria-Angeles Serrera-Figallo, Carmen López-Santos, Angel Barranco, Agustín Rodríguez-González-Elipe, Jose-Luis Gutierrez-Perez
(1) Background: The use of physical barriers to prevent the invasion of gingival and connective tissue cells into bone cavities during the healing process is called guided bone regeneration. The objective of this in-vitro study was to compare the growth of human osteoblasts on Poly(Lactic⁻co⁻Glycolic) (PLGA) membranes modified with oxygen plasma and Hydroxyapatite (HA), silicon dioxide (SiO₂), and titanium dioxide (TiO₂) composite nanoparticles, respectively. (2) Methods: All the membranes received a common treatment with oxygen plasma and were subsequently treated with HA nanostructured coatings (n = 10), SiO₂ (n = 10) and TiO₂ (n = 10), respectively and a PLGA control membrane (n = 10)...
May 8, 2018: Materials
https://www.readbyqxmd.com/read/29729295/electrospinning-an-enabling-nanotechnology-platform-for-drug-delivery-and-regenerative-medicine
#17
Shixuan Chen, Ruiquan Li, Xiaoran Li, Jingwei Xie
Electrospinning provides an enabling nanotechnology platform for generating a rich variety of novel structured materials in many biomedical applications including drug delivery, biosensing, tissue engineering, and regenerative medicine. In this review article, we begin with a thorough discussion on the method of producing 1D, 2D, and 3D electrospun nanofiber materials. In particular, we emphasize on how the 3D printing technology can contribute to the improvement of traditional electrospinning technology for the fabrication of 3D electrospun nanofiber materials as drug delivery devices/implants, scaffolds or living tissue constructs...
May 2, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29724455/telocytes-in-human-fetal-skeletal-muscle-interstitium-during-early-myogenesis
#18
Mirca Marini, Mirko Manetti, Irene Rosa, Lidia Ibba-Manneschi, Eleonora Sgambati
A new peculiar stromal cell type called telocyte (TC)/CD34-positive stromal cell (i.e. cell with distinctive prolongations named telopodes) has recently been described in various tissues and organs, including the adult skeletal muscle interstitium of mammals. By forming a resident stromal three-dimensional network, TCs have been suggested to participate in different physiological processes within the skeletal muscle tissue, including homeostasis maintenance, intercellular signaling, tissue regeneration/repair and angiogenesis...
April 30, 2018: Acta Histochemica
https://www.readbyqxmd.com/read/29714497/ridge-augmentation-simultaneous-with-immediate-implant-placement-the-subperiosteal-tunneling-technique
#19
Barry P Levin, Stephen J Chu
The efficacy of immediate implant placement has made it an appealing treatment modality in dentistry. Over the past several decades various surgical techniques to minimize the ridge collapse and other adverse changes that occur after tooth extraction have been advocated. This case series proposes a method of soft-tissue augmentation when multiple implants are being immediately placed. The authors describe a subperiosteal tunneling technique that achieves the dual purpose of graft containment/guided bone regeneration and soft-tissue augmentation around maxillary anterior implants...
May 2018: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/29702292/tissue-engineered-spiral-nerve-guidance-conduit-for-peripheral-nerve-regeneration
#20
Wei Chang, Munish B Shah, Paul Lee, Xiaojun Yu
Recently in peripheral nerve regeneration, preclinical studies have shown that the use of nerve guidance conduits (NGCs) with multiple longitudinally channels and intra-luminal topography enhance the functional outcomes when bridging a nerve gap caused by traumatic injury. These features not only provide guidance cues for regenerating nerve, but also become the essential approaches for developing a novel NGC. In this study, a novel spiral NGC with aligned nanofibers and wrapped with an outer nanofibrous tube was first developed and investigated...
April 24, 2018: Acta Biomaterialia
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