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Guided Tissue Regeneration

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https://www.readbyqxmd.com/read/28345934/amphiphilic-nucleating-agents-to-enhance-calcium-phosphate-growth-on-polymeric-surfaces
#1
Laura Caetano Escobar da Silva, Bruna Antunes Más, Eliana Aparecida de Rezende Duek, Richard Landers, Celso Aparecido Bertran, Maria Do Carmo Goncalves
Poly(ɛ-caprolactone) (PCL) is an aliphatic polyester widely explored in the preparation of guided bone regeneration (GBR) membranes due to its interesting mechanical properties and biodegradability. However, PCL high hydrophobicity often impairs cell adhesion and proliferation as well as calcium phosphate growth, all of which are crucial to achieve suitable bone-tissue integration. In this work, aiming to achieve less hydrophobic surfaces, amphiphilic molecules were added at low concentrations to the polymeric dope solutions that generated the GBR membranes...
March 27, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28338421/harnessing-the-osteogenicity-of-in-vitro-stem-cell-derived-mineralized-extracellular-matrix-as-3d-biotemplate-to-guide-bone-regeneration
#2
Yoke Chin Chai, Johanna Bolander, Ioannis Papantoniou, Jennifer Patterson, Jef Vleugels, Jan Schrooten, Frank P Luyten
Advanced biomaterials that are capable of guiding robust bone regeneration are highly demanded for translational therapy of bone defects or bone augmentation in clinics. One of the strategic approaches is to produce tissue engineering (TE) constructs that mediate bone regeneration by recapitulating the natural bone formation or healing process. In this study, we aimed at producing devitalized mineralized carriers with augmented bone forming capacity via a modified culture protocol (i.e., culture conditions with high calcium and/or phosphate concentrations) that first promotes cell growth and, subsequently, mineralized extracellular matrix (ECM) deposition by human periosteum-derived osteoprogenitor cells (hPDCs) on additive manufactured three-dimensional (3D) porous titanium (Ti)-based scaffolds...
March 24, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28327149/release-kinetics-and-mitogenic-capacity-of-collagen-barrier-membranes-supplemented-with-secretome-of-activated-platelets-the-in-vitro-response-of-fibroblasts-of-the-periodontal-ligament-and-the-gingiva
#3
Eva-Maria Mozgan, Michael Edelmayer, Klara Janjić, Manuela Pensch, Michael B Fischer, Andreas Moritz, Hermann Agis
BACKGROUND: Platelet preparations can stimulate the healing process and have mitogenic properties. We hypothesized that collagen barrier membranes (CBM), clinically used in guided bone regeneration and guided tissue regeneration, can serve as carriers for platelet secretome. METHODS: Secretome was generated from washed platelets and unwashed platelets (washed/unwashed PSEC) and lyophilized onto CBM. Overall appearance of CBM was evaluated by scanning electron microscopy...
March 21, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28327066/guided-tissue-regeneration-in-four-teeth-using-a-liquid-polymer-membrane
#4
Jennifer B Alterman, John F Huff
Periodontal disease is one of the most common diseases diagnosed in dogs and cats. Guided tissue regeneration (GTR) is a treatment alternative to extraction of strategically important teeth. The barrier membrane used in the GTR procedure is of key importance. The purpose of this case series was to evaluate a liquid polymer gel as a membrane for GTR. The polymer gel ( N-methyl-2-pyrrolidone and poly [DL-lactide]) combined with 8.5% doxycycline hyclate was used in place of a traditional membrane in 4 teeth. The teeth were re-examined 6 months postoperatively for radiographic evaluation...
September 2016: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/28324629/electrospun-nerve-guide-scaffold-of-poly-%C3%AE%C2%B5-caprolactone-collagen-nano-bioglass-an-in-vitro-study-in-peripheral-nerve-tissue-engineering
#5
Forouzan Mohamadi, Somayeh Ebrahimi-Barough, Mohammad Reza Nourani, Mohammad Ali Derakhshan, Vahabodin Goodarzi, Mohammad Sadegh Nazockdast, Mehdi Farokhi, Roksana Tajerian, Reza Faridi Majidi, Jafar Ai
In among of various methods, nerve tissue engineering (NTE) is one of the applicable methods to reconstruct damaged nerve tissues. Electrospinning technique and biomaterials are often considered to fabricate fibrous tissue engineered conduits which have great similarity to the extracellular matrix on fiber structure. Polymer blending is one of the most effective methods for production of new materials with outstanding features. In this research, conduit structures as main part of the peripheral nerve regeneration based on polymer blend nanocomposites PCL/Collagen/NBG (poly (ε-caprolactone)/Collagen/nano bioglass) were manufactured by electrospinning technique...
March 21, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28318155/-biomineralization-of-electrospun-polycaprolactone-guided-bone-regeneration-membrane
#6
Deng Xia, Bai Shi
OBJECTIVE: To evaluate the biomineralization of the tissue-engineering electrospun polycaprolactone (PCL) scaffold and its potential use for guided bone regeneration (GBR) membranes. METHODS: PCL ultrafinefiber scaffolds were fabricated by electrospinning and then immersed in supersaturated calcification solution (SCS) for biomineralization investigation. The electrospun PCL scaffolds and the calcium phosphate coating were identified by scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR)...
December 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28315439/interaction-of-chitin-chitosan-with-salivary-and-other-epithelial-cells-an-overview
#7
REVIEW
Sharvari Vijaykumar Patil, Lalitha S Y Nanduri
Chitin and its deacetylated form, chitosan, have been widely used for tissue engineering of both epithelial and mesenchymal tissues. Epithelial cells characterised by their sheet-like tight cellular arrangement and polarised nature, constitute a major component in various organs and play a variety of roles including protection, secretion and maintenance of tissue homeostasis. Regeneration of damaged epithelial tissues has been studied using biomaterials such as chitin, chitosan, hyaluronan, gelatin and alginate...
March 14, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28314215/a-metabolomic-approach-shows-sphingosine-1-phosphate-and-lysophospholipids-as-mediators-of-the-therapeutic-effect-of-liver-growth-factor-in-emphysema
#8
A Navarrete, F J Rupérez, T O Mendes, S Pérez-Rial, A Girón-Martínez, R Terrón-Expósito, J J Díaz-Gil, G Peces-Barba, C Barbas, A García
Tobacco smoke exposure is the principal cause of lung tissue destruction, which in turn results in emphysema that leads into shortness of breath. Liver growth factor (LGF, a cell and tissue regenerating factor with therapeutic activity in several organs) has antifibrotic and antioxidant properties that could be useful to promote lung tissue regenerating capacity in damaged lungs. The current study has examined differences in metabolite profiles (fingerprints) of plasma from mice (strain C57BL/6J, susceptible to develop emphysema) exposed to tobacco smoke during six months...
February 27, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28298820/the-efficacy-of-transgingival-probing-in-class-ii-buccal-furcation-defects-treated-by-guided-tissue-regeneration
#9
Monika Bansal, Tej Bali Singh
BACKGROUND: The objectives of the present study were to establish transgingival probing as an evaluating method in the clinical studies of periodontal regenerative techniques and to compare the effectiveness of transgingival probing to the surgical entry. MATERIALS AND METHODS: Ten systemically healthy persons (20-50 years) with moderate to severe chronic periodontitis participated in this study. These cases were recruited into the study only when they fulfilled the eligibility criteria...
July 2016: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/28278282/persistent-fibrosis-hypertrophy-and-sarcomere-disorganisation-after-endoscopy-guided-heart-resection-in-adult-xenopus
#10
Lindsey Marshall, Céline Vivien, Fabrice Girardot, Louise Péricard, Barbara A Demeneix, Laurent Coen, Norin Chai
Models of cardiac repair are needed to understand mechanisms underlying failure to regenerate in human cardiac tissue. Such studies are currently dominated by the use of zebrafish and mice. Remarkably, it is between these two evolutionary separated species that the adult cardiac regenerative capacity is thought to be lost, but causes of this difference remain largely unknown. Amphibians, evolutionary positioned between these two models, are of particular interest to help fill this lack of knowledge. We thus developed an endoscopy-based resection method to explore the consequences of cardiac injury in adult Xenopus laevis...
2017: PloS One
https://www.readbyqxmd.com/read/28276147/implant-guided-supracrestal-alveolar-bone-growth-using-scaffolds-bmp-2-and-novel-scaffold-retaining-device
#11
Bo Wen, David Shafer, Peter Schleier, David Pendrys, Liisa Kuhn, Martin Freilich
OBJECTIVE: To evaluate the efficacy of various scaffold systems and a Ti scaffold-retaining device with and without non-glycosylated rhBMP-2 (BMP-2) for increasing the vertical alveolar bone growth in the intra-oral mini-pig model. METHODS: Forty-eight Straumann Bone Level implants with hydrophilic (SLActive) surfaces were partially embedded in mandibles of 12 adult mini-pigs with the shoulder of the implant located 3 mm above the bone crest. Twenty-four implants were placed in conjunction with BMP-2 (50 μg) incorporated within resorbable scaffolds...
March 9, 2017: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/28275782/-construction-of-leptin-gene-modified-tissue-engineered-composites-in-vitro
#12
Bao-Yu Zheng, Meng-Jiao He, Jun Jiang, Kai Luo, Yu-Ling Chen, Fu-Hua Yan
PURPOSE: To evaluate the feasibility of constructing tissue engineered composites in vitro by combining human leptin (hLEP) gene modified rat bone marrow stromal cells (BMSCs) and guided tissue regeneration collagen membrane (Bio-Gide). METHODS: BMSCs of SD rats were isolated and cultured by whole bone marrow adherent method. BMSCS were transfected with adenovirus carrying hLEP gene (Ad-hLEP-EGFP) and observed under inverted fluorescence microscope. Enzyme linked immunosorbent assay (ELISA) was used to detect the expression of hLEP...
December 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/28274052/efficacy-of-natural-and-allopathic-antimicrobial-agents-incorporated-onto-guided-tissue-regeneration-membrane-against-periodontal-pathogens-an-in-vitro-study
#13
Neha Mehrotra, Ajay Reddy Palle, Rajani Kumar Gedela, Sanjay Vasudevan
INTRODUCTION: Periodontal disease is one of the most prevalent afflictions worldwide. It is an infection of the periodontium as a result of subgingival colonization of the specific microbiota, leading to loss of attachment, which requires optimal care for regeneration to its pre-disease state. Guided Tissue Regeneration (GTR) is one of the successful treatment modalities in Periodontal Regenerative Therapy, but is vulnerable to bacterial colonization. The conflict between usage of classical antibiotics and plant origin antimicrobial agents has recently been in the limelight...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28268018/elastin-like-protein-hyaluronic-acid-elp-ha-hydrogels-with-decoupled-mechanical-and-biochemical-cues-for-cartilage-regeneration
#14
Danqing Zhu, Huiyuan Wang, Pavin Trinh, Sarah C Heilshorn, Fan Yang
Hyaluronic acid (HA) is a major component of cartilage extracellular matrix and is an attractive material for use as 3D injectable matrices for cartilage regeneration. While previous studies have shown the promise of HA-based hydrogels to support cell-based cartilage formation, varying HA concentration generally led to simultaneous changes in both biochemical cues and stiffness. How cells respond to the change of biochemical content of HA remains largely unknown. Here we report an adaptable elastin-like protein-hyaluronic acid (ELP-HA) hydrogel platform using dynamic covalent chemistry, which allows variation of HA concentration without affecting matrix stiffness...
March 3, 2017: Biomaterials
https://www.readbyqxmd.com/read/28267421/use-of-pig-as-a-model-for-mesenchymal-stem-cell-therapies-for-bone-regeneration
#15
Marcello Rubessa, Kathryn Polkoff, Massimo Bionaz, Elisa Monaco, Derek J Milner, Scott J Holllister, Michael S Goldwasser, Matthew B Wheeler
Bone is a plastic tissue with a large healing capability. However, extensive bone loss due to disease or trauma requires extreme therapy such as bone grafting or tissue-engineering applications. Presently, bone grafting is the gold standard for bone repair, but presents serious limitations including donor site morbidity, rejection, and limited tissue regeneration. The use of stem cells appears to be a means to overcome such limitations. Bone marrow mesenchymal stem cells (BMSC) have been the choice thus far for stem cell therapy for bone regeneration...
March 7, 2017: Animal Biotechnology
https://www.readbyqxmd.com/read/28257218/modified-double-papillae-flap-technique-with-subepithelial-connective-tissue-graft-for-root-coverage-in-the-esthetic-zone-case-report
#16
Gustavo Javier Salazar Littuma, Leonardo Bez, Camilo Andres Villabona Lopez, Cesar Augusto Magalhães Benfatti, Ricardo de Souza Magini
Gingival recession can compromise the esthetic appearance, leading to functional problems, hypersensitivity, and root caries. Several techniques have been implicated for root coverage, which includes pedicle grafts, free gingival grafts, connective tissue grafts, and guided-tissue regeneration. The double-papillae flap associated with subepithelial connective tissue is a predictable technique to cover isolated areas with insufficient attached gingiva apical to a recession. This case report demonstrates a surgical alternative to the technique using a sling periosteal suture to stabilize the connective tissue and pedicle flap during the initial phase of healing, increasing the potential of this periodontal procedure for gingival recession coverage...
March 2017: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/28251054/surface-curvature-differentially-regulates-stem-cell-migration-and-differentiation-via-altered-attachment-morphology-and-nuclear-deformation
#17
Maike Werner, Sébastien B G Blanquer, Suvi P Haimi, Gabriela Korus, John W C Dunlop, Georg N Duda, Dirk W Grijpma, Ansgar Petersen
Signals from the microenvironment around a cell are known to influence cell behavior. Material properties, such as biochemical composition and substrate stiffness, are today accepted as significant regulators of stem cell fate. The knowledge of how cell behavior is influenced by 3D geometric cues is, however, strongly limited despite its potential relevance for the understanding of tissue regenerative processes and the design of biomaterials. Here, the role of surface curvature on the migratory and differentiation behavior of human mesenchymal stem cells (hMSCs) has been investigated on 3D surfaces with well-defined geometric features produced by stereolithography...
February 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28247348/muscle-interstitial-cells-a-brief-field-guide-to-non-satellite-cell-populations-in-skeletal-muscle
#18
Francesco Saverio Tedesco, Louise A Moyle, Eusebio Perdiguero
Skeletal muscle regeneration is mainly enabled by a population of adult stem cells known as satellite cells. Satellite cells have been shown to be indispensable for adult skeletal muscle repair and regeneration. In the last two decades, other stem/progenitor cell populations resident in the skeletal muscle interstitium have been identified as "collaborators" of satellite cells during regeneration. They also appear to have a key role in replacing skeletal muscle with adipose, fibrous, or bone tissue in pathological conditions...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28231509/a-single-injection-of-protein-loaded-coacervate-gel-significantly-improves-cardiac-function-post-infarction
#19
H K Awada, D W Long, Z Wang, M P Hwang, K Kim, Y Wang
After myocardial infarction (MI), the heart undergoes fibrotic pathological remodeling instead of repair and regeneration. With multiple pathologies developing after MI, treatment using several proteins is expected to address this range of pathologies more effectively than a single-agent therapy. A factorial design of experiments study guided us to combine three complementary factors in one injection: tissue inhibitor of metalloproteinases-3 (TIMP-3) was embedded in a fibrin gel for signaling in the initial phase of the treatment, while basic fibroblast growth factor (FGF-2) and stromal cell-derived factor 1-alpha (SDF-1α) were embedded in heparin-based coacervates for sustained release and distributed within the same fibrin gel to exert their effects over a longer period...
February 17, 2017: Biomaterials
https://www.readbyqxmd.com/read/28228626/osteogenic-induction-of-bone-marrow-mesenchymal-cells-on-electrospun-polycaprolactone-chitosan-nanofibrous-membrane
#20
Ying He, Wei Wang, Xuyan Tang, Xin Liu
A novel chitosan/polycaprolactone (CS/PCL) nanofibrous membrane by electrospinning was developed for guided tissue regeneration (GTR) to improve mechanical properties and to promote osteogenic differentiation. Firstly, chitosan and PCL solutions of different weight ratios (0/100, 30/70, 50/50) were mixed and then electrospun. Our data demonstrated that the CS/PCL (30/70) nanofibrous membrane promoted an increased rBMSCs proliferation when compared to the CS/PCL (50/50) membrane and pure PCL (0/100) membrane...
February 22, 2017: Dental Materials Journal
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