keyword
MENU ▼
Read by QxMD icon Read
search

Guided Tissue Regeneration

keyword
https://www.readbyqxmd.com/read/28221776/the-horizon-of-materiobiology-a-perspective-on-material-guided-cell-behaviors-and-tissue-engineering
#1
Yulin Li, Yin Xiao, Changsheng Liu
Although the biological functions of cell and tissue can be regulated by biochemical factors (e.g., growth factors, hormones), the biophysical effects of materials on the regulation of biological activity are receiving more attention. In this Review, we systematically summarize the recent progress on how biomaterials with controllable properties (e.g., compositional/degradable dynamics, mechanical properties, 2D topography, and 3D geometry) can regulate cell behaviors (e.g., cell adhesion, spreading, proliferation, cell alignment, and the differentiation or self-maintenance of stem cells) and tissue/organ functions...
February 21, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28221007/ionic-colloidal-molding-as-a-biomimetic-scaffolding-strategy-for-uniform-bone-tissue-regeneration
#2
Jian Zhang, Jinpeng Jia, Jimin P Kim, Hong Shen, Fei Yang, Qiang Zhang, Meng Xu, Wenzhi Bi, Xing Wang, Jian Yang, Decheng Wu
Inspired by the highly ordered nanostructure of bone, nanodopant composite biomaterials are gaining special attention for their ability to guide bone tissue regeneration through structural and biological cues. However, bone malformation in orthopedic surgery is a lingering issue, partly due to the high surface energy of traditional nanoparticles contributing to aggregation and inhomogeneity. Recently, carboxyl-functionalized synthetic polymers have been shown to mimic the carboxyl-rich surface motifs of non-collagenous proteins in stabilizing hydroxyapatite and directing intrafibrillar mineralization in-vitro...
February 21, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28218282/calcium-spikes-waves-and-oscillations-in-a-large-patterned-epithelial-tissue
#3
Ramya Balaji, Christina Bielmeier, Hartmann Harz, Jack Bates, Cornelia Stadler, Alexander Hildebrand, Anne-Kathrin Classen
While calcium signaling in excitable cells, such as muscle or neurons, is extensively characterized, calcium signaling in epithelial tissues is little understood. Specifically, the range of intercellular calcium signaling patterns elicited by tightly coupled epithelial cells and their function in the regulation of epithelial characteristics are little explored. We found that in Drosophila imaginal discs, a widely studied epithelial model organ, complex spatiotemporal calcium dynamics occur. We describe patterns that include intercellular waves traversing large tissue domains in striking oscillatory patterns as well as spikes confined to local domains of neighboring cells...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28210970/a-suspended-carbon-fiber-culture-to-model-myelination-by-human-schwann-cells
#4
Antonio Merolli, Yong Mao, Joachim Kohn
Understanding of myelination/remyelination process is essential to guide tissue engineering for nerve regeneration. In vitro models currently used are limited to cell population studies and cannot easily identify individual cell contribution to the process. We established a novel model to study the contribution of human Schwann cells to the myelination process. The model avoids the presence of neurons in culture; Schwann cells respond solely to the biophysical properties of an artificial axon. The model uses a single carbon fiber suspended in culture media far from the floor of the well...
April 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28196155/subperiosteal-minimally-invasive-aesthetic-ridge-augmentation-technique-smart-a-new-standard-for-bone-reconstruction-of-the-jaws
#5
Ernesto A Lee
Traditional guided bone regeneration techniques include flap mobilization and placement of a bone graft, often with the use of space-maintaining devices and cell-occlusive membranes. This approach is associated with frequent complications that negatively affect the outcome of the augmentation and the peri-implant soft tissue esthetics. Although current tunneling techniques have focused on periodontal soft tissue applications, earlier publications described their use for horizontal augmentation of mandibular posterior edentulous ridges in full-denture patients...
March 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28196152/human-histologic-evidence-of-reosseointegration-around-an-implant-affected-with-peri-implantitis-following-decontamination-with-sterile-saline-and-antiseptics-a-case-history-report
#6
Paul Fletcher, Daniel Deluiz, Eduardo Mb Tinoco, John L Ricci, Dennis P Tarnow, Justine Monnerat Tinoco
The treatment of peri-implant disease is one of the most controversial topics in implant dentistry. The multifactorial etiology and the myriad proposed techniques for managing the problem make successful decontamination of an implant surface affected by peri-implantitis one of the more unpredictable challenges dental practitioners have to face. This article presents the first known published case report demonstrating human histologic evidence of reosseointegration using a plastic curette for mechanical debridement and dilute sodium hypochlorite, hydrogen peroxide, and sterile saline for chemical detoxification...
February 14, 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28192870/clinical-and-immunohistochemical-performance-of-lyophilized-platelet-rich-fibrin-ly-prf-on-tissue-regeneration
#7
Jianming Zhang, Xingying Qi, Xiaoding Luo, Dan Li, Haorong Wang, Ting Li
BACKGROUND: Platelet-rich fibrin (PRF) has been widely used in oral implantology and other fields, but benefits of the fresh PRF (FPRF (fresh platelet-rich fibrin)) were consequently limited because of its short-term application. Thus, a protocol for the combination of PRF and lyophilization comes up in the present study to address the issue of PRF storage and delayed clinical application, which has little been reported in this field at home and abroad by now. PURPOSE: The aim of the present study was to evaluate the applicability of lyophilized platelet-rich fibrin (Ly-PRF) used as the scaffold material for craniofacial tissue regeneration and to compare its biochemical properties with commonly used fresh PRF...
February 13, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28191446/guiding-osteogenesis-of-mesenchymal-stem-cells-using-carbon-based-nanomaterials
#8
REVIEW
Ee-Seul Kang, Da-Seul Kim, Intan Rosalina Suhito, Sung-Sik Choo, Seung-Jae Kim, Inbeom Song, Tae-Hyung Kim
In the field of regenerative medicine, stem cells are highly promising due to their innate ability to generate multiple types of cells that could replace/repair damaged parts of human organs and tissues. It has been reported that both in vitro and in vivo function/survival of stem cells could significantly be improved by utilizing functional materials such as biodegradable polymers, metal composites, nanopatterns and nanohybrid particles. Of various biocompatible materials available for use in stem cell-based therapy and research, carbon-based materials-including fullerenes graphene/graphene oxide and carbon nanotubes-have been found to possess unique physicochemical characteristics that contribute to the effective guidance of stem cell differentiation into specific lineages...
2017: Nano Converg
https://www.readbyqxmd.com/read/28183613/pdlla-honeycomb-like-scaffolds-with-a-high-loading-of-superhydrophilic-graphene-multi-walled-carbon-nanotubes-promote-osteoblast-in-vitro-functions-and-guided-in-vivo-bone-regeneration
#9
Edmundo Silva, Luana Marotta Reis de Vasconcellos, Bruno V M Rodrigues, Danilo Martins Dos Santos, Sergio P Campana-Filho, Fernanda Roberta Marciano, Thomas J Webster, Anderson Oliveira Lobo
Herein, we developed honeycomb-like scaffolds by combining poly (d, l-lactic acid) (PDLLA) with a high amount of graphene/multi-walled carbon nanotube oxides (MWCNTO-GO, 50% w/w). From pristine multi-walled carbon nanotubes (MWCNT) powders, we produced MWCNTO-GO via oxygen plasma etching (OPE), which promoted their exfoliation and oxidation. Initially, we evaluated PDLLA and PDLLA/MWCNTO-GO scaffolds for tensile strength tests, cell adhesion and cell viability (with osteoblast-like MG-63 cells), alkaline phosphatase (ALP, a marker of osteoblast differentiation) activity and mineralized nodule formation...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28181688/dental-implants-and-bone-augmentation-in-hiv-infected-patients-under-haart-case-report-and-review-of-the-literature
#10
Fábio Vidal, Rafael Vidal, Jeter Bochnia, Rodrigo Carvalho de Souza, Lucio Souza Gonçalves
The present study reviewed the literature regarding dental implants in HIV-infected patients and reports the long-term follow-up of three clinical cases of patients under HAART that received bone augmentation and dental implants. The first case presents a young patient with a large defect in the mandible, as a consequence of a longitudinal fracture, that was treated with guided bone regeneration (GBR) previously to implant placement. The second case reported is middle-aged man with a fractured upper lateral incisor treated with immediate placement and simultaneous GBR to repair the dehiscence due to the buccal bone resorption...
February 9, 2017: Special Care in Dentistry
https://www.readbyqxmd.com/read/28177132/in-vitro-evaluation-of-the-human-gingival-fibroblast-gingival-mesenchymal-stem-cell-dynamics-through-perforated-guided-tissue-membranes-cell-migration-proliferation-and-membrane-stiffness-assay
#11
A Y Gamal, N N Al-Berry, A A Hassan, L A Rashed, V J Iacono
BACKGROUND: Migration of gingival fibroblasts/gingival mesenchymal stem cells through macro-perforated barrier membranes may allow them to participate positively in periodontal regeneration. The optimal guided tissue membrane perforation diameter that could favor maximum cell migration into the defect area and at the same time act as an occlusive barrier for gingival epithelium and its associated gingival extracellular matrix component is not yet identified. MATERIAL AND METHODS: Cultured human gingival fibroblasts/gingival mesenchymal stem cells were placed in the upper chambers of 12-well collagen-coated polytetrafluoroethylene transwells, which were manually perforated with 0...
February 8, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28169834/development-of-biomimetic-micro-patterned-device-incorporated-with-neurotrophic-gradient-and-supportive-schwann-cells-for-the-applications-in-neural-tissue-engineering
#12
Chia-Wei Yeh, Li-Wen Wang, Hsi-Chin Wu, Yi-Kong Hsieh, Jane Wang, Ming-Hong Chen, Tzu-Wei Wang
In these years, the artificial nerve guidance conduit has been developed as an alternative way to repair peripheral nerve injury. Unlike autologous nerve graft, the artificial nerve guidance conduit without proper stimulating factors and guidance cues still cannot obtain satisfactory prognosis for clinical patients. In this study, a biodegradable polymer-based implantable device has been developed and characterized. By incorporating three stimulating factors: 1) micro-patterned surface that can directionally guide the axon as physical cue; 2) neurotrophic gradient membrane that can continually attract axon outgrowth from the proximal to distal stump as chemical cue; 3) Schwann cells that can support the growth of neurite and form myelin sheath around axon as biological cue, we expect that this construct can be used as a promising nerve guidance conduit for peripheral nerve regeneration...
February 7, 2017: Biofabrication
https://www.readbyqxmd.com/read/28169513/multilayer-nanoscale-encapsulation-of-biofunctional-peptides-to-enhance-bone-tissue-regeneration-in-vivo
#13
Piergiorgio Gentile, Ana Marina Ferreira, Jill T Callaghan, Cheryl A Miller, Joss Atkinson, Christine Freeman, Paul V Hatton
Bone tissue healing is a dynamic process that is initiated by the recruitment of osteoprogenitor cells followed by their migration, proliferation, differentiation, and development of a mineralizing extracellular matrix. The work aims to manufacture a functionalized porous membrane that stimulates early events in bone healing for initiating a regenerative cascade. Layer-by-layer (LbL) assembly is proposed to modify the surface of osteoconductive electrospun meshes, based on poly(lactic-co-glycolic acid) and nanohydroxyapatite, by using poly(allylamine hydrochloride) and poly(sodium 4-styrenesulfonate) as polyelectrolytes...
February 7, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28166711/biomaterial-guided-gene-delivery-for-musculoskeletal-tissue-repair
#14
Justin Luis Madrigal, Roberta Sessa Stilhano, Eduardo Silva
Gene therapy is a promising strategy for musculoskeletal tissue repair and regeneration where local and sustained expression of proteins and/or therapeutic nucleic acids can be achieved. However, the musculoskeletal tissues present unique engineering and biological challenges as recipients of genetic vectors. Targeting specific cell populations, regulating expression in vivo, and overcoming the harsh environment of damaged tissue accompany the general concerns of safety and efficacy common to all applications of gene therapy...
February 6, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28160588/reliability-of-new-poly-lactic-co-glycolic-acid-membranes-treated-with-oxygen-plasma-plus-silicon-dioxide-layers-for-pre-prosthetic-guided-bone-regeneration-processes
#15
G Castillo-Dalí, R Castillo-Oyagüe, A Batista-Cruzado, C López-Santos, A Rodríguez-González-Elipe, J-L Saffar, C-D Lynch, J-L Gutiérrez-Pérez, D Torres-Lagares
BACKGROUND: The use of cold plasmas may improve the surface roughness of poly(lactic-co-glycolic) acid (PLGA) membranes, which may stimulate the adhesion of osteogenic mediators and cells, thus accelerating the biodegradation of the barriers. Moreover, the incorporation of metallic-oxide particles to the surface of these membranes may enhance their osteoinductive capacity. Therefore, the aim of this paper was to evaluate the reliability of a new PLGA membrane after being treated with oxygen plasma (PO2) plus silicon dioxide (SiO2) layers for guided bone regeneration (GBR) processes...
February 4, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28156187/a-peri-implantitis-associated-with-a-pre-existing-pathology
#16
S E-L I M Oh
This case report presents a treatment of peri-implantitis associated with a pre-existing pathology. Peri-implantitis around the implant #19 was detected from pus discharge upon probing. Guided bone regeneration was performed to treat peri-implantitis with the administration of antibiotics. The histopathologic evaluation of soft tissue taken from the circumferential defect around the implant exhibited a cyst. The post-surgical CBCT and the follow-up radiograph confirmed the maturing bone graft and a reduced size of the defect around the implant...
February 3, 2017: Journal of Oral Implantology
https://www.readbyqxmd.com/read/28138239/nerve-guidance-conduit-with-a-hybrid-structure-of-a-plga-microfibrous-bundle-wrapped-in-a-micro-nanostructured-membrane
#17
Shih-Wen Peng, Ching-Wen Li, Ing-Ming Chiu, Gou-Jen Wang
Nerve repair in tissue engineering involves the precise construction of a scaffold to guide nerve cell regeneration in the desired direction. However, improvements are needed to facilitate the cell migration/growth rate of nerves in the center of a nerve conduit. In this paper, we propose a nerve guidance conduit with a hybrid structure comprising a microfibrous poly(lactic-co-glycolic acid) (PLGA) bundle wrapped in a micro/nanostructured PLGA membrane. We applied sequential fabrication processes, including photolithography, nano-electroforming, and polydimethylsiloxane casting to manufacture master molds for the repeated production of the PLGA subelements...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28130867/in-vivo-guided-vascular-regeneration-with-a-non-porous-elastin-like-polypeptide-hydrogel-tubular-scaffold
#18
Atsushi Mahara, Kristi L Kiick, Tetsuji Yamaoka
Herein, we demonstrate a new approach for small-caliber vascular reconstruction using a non-porous elastin-like polypeptide hydrogel tubular scaffold, based on the concept of guided vascular regeneration (GVR). The scaffolds are composed of elastin-like polypeptide, (Val-Pro-Gly-Ile-Gly)n , for compliance matching and antithrombogenicity and an Arg-Gly-Asp (RGD) motif for connective tissue regeneration. When the polypeptide was mixed with an aqueous solution of β-[Tris(hydroxymethyl)phosphino]propionic acid at 37°C, the polypeptide hydrogel was rapidly formed...
January 28, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28118552/decellularized-tooth-bud-scaffolds-for-tooth-regeneration
#19
W Zhang, B Vazquez, D Oreadi, P C Yelick
Whole tooth regeneration approaches currently are limited by our inability to bioengineer full-sized, living replacement teeth. Recently, decellularized organ scaffolds have shown promise for applications in regenerative medicine by providing a natural extracellular matrix environment that promotes cell attachment and tissue-specific differentiation leading to full-sized organ regeneration. We hypothesize that decellularized tooth buds (dTBs) created from unerupted porcine tooth buds (TBs) can be used to guide reseeded dental cell differentiation to form whole bioengineered teeth, thereby providing a potential off-the-shelf scaffold for whole tooth regeneration...
January 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28117963/chitosan-intercalated-montmorillonite-poly-vinyl-alcohol-nanofibers-as-a-platform-to-guide-neuron-like-differentiation-of-human-dental-pulp-stem-cells
#20
Hatef Ghasemi Hamidabadi, Zahra Rezvani, Maryam Nazm Bojnordi, Haji Shirinzadeh, Alexander M Seifalian, Mohammad Taghi Joghataei, Mojgan Razaghpour, Abbas Alibakhshi, Abolfazl Yazdanpanah, Maryam Salimi, Masoud Mozafari, Aleksandra M Urbanska, Rui L Reis, Subhas C Kundu, Mazaher Gholipourmalekabadi
In this study, we present a novel chitosan-intercalated montmorillonite/Poly(Vinyl alcohol) (OMMT/PVA) nanofibrous mesh as a microenvironment for guiding differentiation of human dental pulp stem cells (hDPSCs) toward neuron-like cells. The OMMT was prepared through ion exchange reaction between the montmorillonite (MMT) and chitosan. The PVA solutions containing various concentrations of OMMT were electrospun to form 3-D OMMT-PVA nanofibrous meshes. The biomechanical and biological characteristics of the nanofibrous meshes were evaluated by ATR-FTIR, XRD, SEM, MTT, LDH specific activity, contact angle, and DAPI staining...
January 24, 2017: ACS Applied Materials & Interfaces
keyword
keyword
42687
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"