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Guided Tissue Regeneration

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https://www.readbyqxmd.com/read/29143459/the-spatial-patterning-of-rgd-and-bmp-2-mimetic-peptides-at-the-subcellular-scale-modulates-human-mesenchymal-stem-cells-osteogenesis
#1
I Bilem, L Plawinski, P Chevallier, C Ayela, E D Sone, G Laroche, M C Durrieu
Engineering artificial extracellular matrices (ECMs), based on the biomimicry of the spatial distribution of proteins and growth factors within their native microenvironment, is of great importance for understanding mechanisms of bone tissue regeneration. Herein, photolithography is used to decorate glass surfaces with subcellular patterns of RGD and BMP-2 ligands; two mimetic peptides recognized to be involved in stem cells osteogenesis. The biological relevance of well-defined RGD and BMP-2 patterned surfaces is evaluated by investigating the differentiation of human mesenchymal stem cells (hMSCs) into osteoblasts, in the absence of induction media...
November 16, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29137814/biofabrication-a-guide-to-technology-and-terminology
#2
REVIEW
Lorenzo Moroni, Thomas Boland, Jason A Burdick, Carmelo De Maria, Brian Derby, Gabor Forgacs, Jürgen Groll, Qing Li, Jos Malda, Vladimir A Mironov, Carlos Mota, Makoto Nakamura, Wenmiao Shu, Shoji Takeuchi, Tim B F Woodfield, Tao Xu, James J Yoo, Giovanni Vozzi
Biofabrication holds the potential to generate constructs that more closely recapitulate the complexity and heterogeneity of tissues and organs than do currently available regenerative medicine therapies. Such constructs can be applied for tissue regeneration or as in vitro 3D models. Biofabrication is maturing and growing, and scientists with different backgrounds are joining this field, underscoring the need for unity regarding the use of terminology. We therefore believe that there is a compelling need to clarify the relationship between the different concepts, technologies, and descriptions of biofabrication that are often used interchangeably or inconsistently in the current literature...
November 11, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/29133168/autologous-granulation-tissue-tubes-for-replacement-of-urethral-defects-an-experimental-study-in-male-rabbits
#3
Shi-Wei Jiang, Zhong-Hua Xu, Yuan-Yuan Zhao, Lei Yan, Zun-Lin Zhou, Gang-Li Gu
INTRODUCTION: Tubularized urethroplasty is commonly performed in clinical practice using genital skin flaps, bladder mucosa, and buccal mucosa. However, the long-term effects are not satisfying, and donor site morbidities remain a problem. Besides, those grafts are unavailable with malignant conditions of the urinary tract, a history of lichen sclerosis, or oral disease. OBJECTIVE: An autologous granulation tissue tube of any required length and diameter can be produced by implanting foreign objects subcutaneously (Summary Fig...
October 31, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29125136/mechanically-stable-surface-hydrophobilized-chitosan-nanofibrous-barrier-membranes-for-guided-bone-regeneration
#4
Chaoxi Wu, Hengjie Su, Anastasios Karydis, Kenneth M Anderson, Najib Ghadri, Shunqing Tang, Yifei Wang, Joel D Bumgardner
The use of chitosan based nanofiber membranes in guided bone regeneration (GBR) is limited by its uncontrolled swelling and mechanical instability in aqueous environments. This paper describes the significantly improved stability and properties of surface butyrylated chitosan nanofiber (BCSNF) membranes that greatly enhance their potential in GBR. The BCSNF membranes exhibited an overall degree of substitution of 1.61, an average diameter of 99.3 ± 33.7 nm, and a 75% decrease in swelling with an approximate doubling in suture pull out strengths as compared to unmodified fibers in aqueous environment...
November 10, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/29121452/3d-maskless-micropatterning-for-regeneration-of-highly-organized-tubular-tissues
#5
Chi Ma, Tiejun Qu, Bei Chang, Yan Jing, Jerry Q Feng, Xiaohua Liu
Micropatterning is a widely used powerful tool to create highly ordered microstructures on material surfaces. However, due to technical limitations, the integration of micropatterned microstructures into bioinspired 3D scaffolds to successfully regenerate well-organized functional tissues is not achieved. In this work, a unique maskless micropatterning technology is reported to create 3D nanofibrous matrices with highly organized tubular architecture for tissue regeneration. This micropatterning method is a laser-guided, noncontact, high-precision, flexible computer programming of machining process that can create highly ordered tubules with the density ranged from 1000 to 60 000 mm(-2) and the size varied from 300 nm to 30 µm in the bioinspired 3D matrix...
November 9, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29116017/regenerative-potential-of-primary-adult-human-neural-stem-cells-on-micropatterned-bio-implants-boosts-motor-recovery
#6
Carole Davoust, Benjamin Plas, Amélie Béduer, Boris Demain, Anne-Sophie Salabert, Jean Christophe Sol, Christophe Vieu, Laurence Vaysse, Isabelle Loubinoux
BACKGROUND: The adult brain is unable to regenerate itself sufficiently after large injuries. Therefore, hopes rely on therapies using neural stem cell or biomaterial transplantation to sustain brain reconstruction. The aim of the present study was to evaluate the improvement in sensorimotor recovery brought about by human primary adult neural stem cells (hNSCs) in combination with bio-implants. METHODS: hNSCs were pre-seeded on implants micropatterned for neurite guidance and inserted intracerebrally 2 weeks after a primary motor cortex lesion in rats...
November 7, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29115301/mechanical-forces-direct-stem-cell-behaviour-in-development-and-regeneration
#7
REVIEW
Kyle H Vining, David J Mooney
Stem cells and their local microenvironment, or niche, communicate through mechanical cues to regulate cell fate and cell behaviour and to guide developmental processes. During embryonic development, mechanical forces are involved in patterning and organogenesis. The physical environment of pluripotent stem cells regulates their self-renewal and differentiation. Mechanical and physical cues are also important in adult tissues, where adult stem cells require physical interactions with the extracellular matrix to maintain their potency...
November 8, 2017: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/29107632/keratin-biomaterials-augment-anti-inflammatory-macrophage-phenotype-in-vitro
#8
Michele Waters, Pamela VandeVord, Mark Van Dyke
Tissue regeneration following injury is mediated by macrophage recruitment and differentiation in response to environmental signals. In general, macrophages adopt either a classically (M[IFN-γ, LPS]) or alternatively activated (M[IL-4, IL-13] and M[IL-10]) phenotype. Recent studies have highlighted the importance of alternatively activated macrophages in tissue remodeling and repair as well as the contribution of an imbalance of classically and alternatively activated macrophages to tissue degeneration and disease progression...
October 28, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29103485/porous-stable-poly-lactic-acid-ethyl-cellulose-hydroxyapatite-composite-scaffolds-prepared-by-a-combined-method-for-bone-regeneration
#9
Daoyong Mao, Qing Li, Ningning Bai, Hongzhou Dong, Daikun Li
A major challenge in bone tissue engineering is the development of biomimetic scaffolds which should simultaneously meet mechanical strength and pore structure requirements. Herein, we combined technologies of high concentration solvent casting, particulate leaching, and room temperature compression molding to prepare a novel poly(lactic acid)/ethyl cellulose/hydroxyapatite (PLA/EC/HA) scaffold. The functional, structural and mechanical properties of the obtained porous scaffolds were characterized. The results indicated that the PLA/EC/HA scaffolds at the 20wt% HA loading level showed optimal mechanical properties and desired porous structure...
January 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29099679/photobiomodulation-in-neuroscience-a-summary-of-personal-experience
#10
Shimon Rochkind
OBJECTIVE: This review summarizes personal experience with laser photobiomodulation and its potentials for the treatment of peripheral and central nerve system injuries. METHODS AND RESULTS: Laser photobiomodulation was shown to induce nerve cell activation, have a positive effect on metabolism of the nerve cells, and to stimulate nerve sprouting processes. Studies investigating the effects of laser photobiomodulation on injured peripheral nerves in rats reported immediate protective effects which increase the functional activity of the nerve, decrease or prevent scar tissue formation at the injured site, prevent or decrease degeneration in corresponding motor neurons of the spinal cord, and significantly increase axonal growth and myelinization...
November 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29095788/is-bone-graft-or-guided-bone-regeneration-needed-when-placing-immediate-dental-implants-a-systematic-review
#11
Hania AlKudmani, Reham Al Jasser, Sebastiano Andreana
AIMS: To systematically review the effect and type of bone graft and guided bone regeneration around immediate implants on hard and soft tissue changes. METHODS: Three electronic databases were searched up to June 2015. Outcomes consisted of hard and soft tissue dimensional changes. RESULTS: Eight studies were included according to inclusion criteria. Immediate implants with bone grafting had superior soft tissue stability and preserved horizontal ridge dimension and buccal plate thickness, when compared to no grafting...
November 1, 2017: Implant Dentistry
https://www.readbyqxmd.com/read/29095664/graphene-based-scaffolds-on-bone-tissue-engineering
#12
Nasrin Shadjou, Mohammad Hasanzadeh, Balal Khalilzadeh
Tissue engineering has been emerging as a valid approach to the current therapies for bone regeneration/substitution. Tissue-engineered bone constructs have the potential to alleviate the demand arising from the shortage of suitable autograft and allograft materials for augmenting bone healing. Scaffolds play a central role in tissue engineering research, they not only provide as structural support for specific cells but also provide as the templates to guide new tissue growth and construction. In this survey we describe application of graphene based nano-biomaterials for bone tissue engineering...
November 2, 2017: Bioengineered
https://www.readbyqxmd.com/read/29076295/calcium-phosphate-collagen-scaffold-with-aligned-pore-channels-for-enhanced-osteochondral-regeneration
#13
Yun-Jeong Seong, In-Gu Kang, Eun-Ho Song, Hyoun-Ee Kim, Seol-Ha Jeong
This study reports the development of a bilayered scaffold with aligned channels produced via a sequential coextrusion and unidirectional freezing process to facilitate upward bone-marrow stem-cell migration. The biomimetic scaffold with collagen and biphasic calcium phosphate (BCP) layers is successfully fabricated with matching of the cartilage and bone layers. The aligned structure results in an enhancement of the compressive strength, and the channels enable tight anchoring of the collagen layers on the BCP scaffolds compared with a randomly structured porous scaffold...
October 27, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29075116/innovative-biodegradable-poly-l-lactide-collagen-hydroxyapatite-composite-fibrous-scaffolds-promote-osteoblastic-proliferation-and-differentiation
#14
Guoqiang Zhou, Sudan Liu, Yanyan Ma, Wenshi Xu, Wei Meng, Xue Lin, Wenying Wang, Shuxiang Wang, Jinchao Zhang
The development of an artificial bone graft which can promote the regeneration of fractures or diseased bones is currently the most challenging aspect in bone tissue engineering. To achieve the purpose of promoting bone proliferation and differentiation, the artificial graft needs have a similar structure and composition of extracellular matrix. One-step electrospinning method of biocomposite nanofibers containing hydroxyapatite (HA) nanoparticles and collagen (Coll) were developed for potential application in bone tissue engineering...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29073362/effectiveness-of-contour-augmentation-with-guided-bone-regeneration-10-year-results
#15
V Chappuis, L Rahman, R Buser, S F M Janner, U C Belser, D Buser
In aesthetic sites, the integrity of the facial bone wall dimension in the anterior maxilla is jeopardized by physiologic and structural changes postextraction. An effective regenerative protocol is key to reestablish and maintain the hard and soft tissue dimensions over time. The present prospective case series study examined the effectiveness of early implant placement with simultaneous contour augmentation through guided bone regeneration with a 2-layer composite graft in postextraction single-tooth sites over an observation period of 10 y among 20 patients...
October 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29064632/the-effects-of-platelet-derived-growth-factor-bb-on-human-dental-pulp-stem-cells-mediated-dentin-pulp-complex-regeneration
#16
Maolin Zhang, Fei Jiang, Xiaochen Zhang, Shaoyi Wang, Yuqin Jin, Wenjie Zhang, Xinquan Jiang
Dentin-pulp complex regeneration is a promising alternative treatment for the irreversible pulpitis caused by tooth trauma or dental caries. This process mainly relies on the recruitment of endogenous or the transplanted dental pulp stem cells (DPSCs) to guide dentin-pulp tissue formation. Platelet-derived growth factor (PDGF), a well-known potent mitogenic, angiogenic, and chemoattractive agent, has been widely used in tissue regeneration. However, the mechanisms underlying the therapeutic effects of PDGF on dentin-pulp complex regeneration are still unclear...
October 24, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29063586/protein-expression-during-early-stages-of-bone-regeneration-under-hydrophobic-and-hydrophilic-titanium-domes-a-pilot-study
#17
E Calciolari, N Mardas, X Dereka, A K Anagnostopoulos, G T Tsangaris, N Donos
BACKGROUND AND OBJECTIVES: There is significant evidence that, during the early stages of osseointegration, moderately rough hydrophilic (SLActive) surfaces can accelerate osteogenesis and increase bone-to-implant contact in comparison to hydrophobic (SLA) surfaces. However, very little is known regarding the molecular mechanisms behind the influence that surface chemistry modifications to increase hydrophilicity determine on bone healing. The aim of this study was to describe for the first time the proteins and related signalling pathways expressed during early osseous healing stages under SLA and SLActive titanium domes for guided bone regeneration...
October 24, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29053443/enhancement-of-intercellular-electrical-synchronization-by-conductive-materials-in-cardiac-tissue-engineering
#18
Yu Wu, Liang Guo
OBJECTIVE: cardiac tissue regeneration for the treatment of cardiovascular diseases has been of great research interest. Under the hypothesis that electrical synchronization of cardiac cells can be aided by conductive materials, electrically conductive scaffolds have been frequently used to improve cardiac tissue regeneration. However, theoretical analysis is presently absent in examining the underlying mechanism and rationally guiding the design of these conductive scaffolds. METHODS: here, equivalent-circuit models are proposed, in which two adjacent groups of cardiomyocytes are grown either on a bulk conductive substrate or around conductive nanostructures...
October 15, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/29044933/cross-tissue-identification-of-somatic-stem-and-progenitor-cells-using-a-single-cell-rna-seq-derived-gene-signature
#19
Petra C Schwalie, Paloma Ordonez Moran, Joerg Huelsken, Bart Deplancke
A long-standing question in biology is whether multipotent somatic stem and progenitor cells (SSPCs) feature molecular properties that could guide their system-independent identification. Population-based transcriptomic studies have so far not been able to provide a definite answer, given the rarity and heterogeneous nature of these cells. Here, we exploited the resolving power of single-cell RNA-sequencing to develop a computational model that is able to accurately distinguish SSPCs from differentiated cells across tissues...
October 16, 2017: Stem Cells
https://www.readbyqxmd.com/read/29029631/neurotrophic-support-by-traumatized-muscle-derived-multipotent-progenitor-cells-role-of-endothelial-cells-and-vascular-endothelial-growth-factor-a
#20
Heidi R H Zupanc, Peter G Alexander, Rocky S Tuan
BACKGROUND: Adult mesenchymal stem cells (MSCs) have been shown to increase nerve regeneration in animal models of nerve injury. Traumatized muscle-derived multipotent progenitor cells (MPCs) share important characteristics with MSCs and are isolated from severely damaged muscle tissue following surgical debridement. Previous investigations have shown that MPCs may be induced to increase production of several neurotrophic factors, suggesting the possible utility of autologous MPCs in peripheral nerve regeneration following injury...
October 13, 2017: Stem Cell Research & Therapy
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