keyword
MENU ▼
Read by QxMD icon Read
search

Guided Tissue Regeneration

keyword
https://www.readbyqxmd.com/read/29349931/biomimetic-architectures-for-peripheral-nerve-repair-a-review-of-biofabrication-strategies
#1
REVIEW
Paul A Wieringa, Ana Rita Gonçalves de Pinho, Silvestro Micera, Richard J A van Wezel, Lorenzo Moroni
Biofabrication techniques have endeavored to improve the regeneration of the peripheral nervous system (PNS), but nothing has surpassed the performance of current clinical practices. However, these current approaches have intrinsic limitations that compromise patient care. The "gold standard" autograft provides the best outcomes but requires suitable donor material, while implantable hollow nerve guide conduits (NGCs) can only repair small nerve defects. This review places emphasis on approaches that create structural cues within a hollow NGC lumen in order to match or exceed the regenerative performance of the autograft...
January 19, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29336778/damage-induced-reactive-oxygen-species-regulate-vimentin-and-dynamic-collagen-based-projections-to-mediate-wound-repair
#2
Danny LeBert, Jayne M Squirrell, Chrissy Freisinger, Julie Rindy, Netta Golenberg, Grace Frecentes, Angela Gibson, Kevin W Eliceiri, Anna Huttenlocher
Tissue injury leads to early wound-associated reactive oxygen species (ROS) production that mediate tissue regeneration. To identify mechanisms that function downstream of redox signals that modulate regeneration, a vimentin reporter of mesenchymal cells was generated by driving GFP from the vimentin promoter in zebrafish. Early redox signaling mediated vimentin reporter activity at the wound margin. Moreover, both ROS and vimentin were necessary for collagen production and reorganization into projections at the leading edge of the wound...
January 16, 2018: ELife
https://www.readbyqxmd.com/read/29333689/2d-black-phosphorus-reinforced-3d-printed-scaffolds-a-stepwise-countermeasure-for-osteosarcoma
#3
Bowen Yang, Junhui Yin, Yu Chen, Shanshan Pan, Heliang Yao, Youshui Gao, Jianlin Shi
With the ever-deeper understanding of nano-bio interactions and the development of fabrication methodologies of nanomaterials, various therapeutic platforms based on nanomaterials have been developed for next-generation oncological applications, such as osteosarcoma therapy. In this work, a black phosphorus (BP) reinforced 3D-printed scaffold is designed and prepared to provide a feasible countermeasure for the efficient localized treatment of osteosarcoma. The in situ phosphorus-driven, calcium-extracted biomineralization of the intra-scaffold BP nanosheets enables both photothermal ablation of osteosarcoma and the subsequent material-guided bone regeneration in physiological microenvironment, and in the meantime endows the scaffolds with unique physicochemical properties favoring the whole stepwise therapeutic process...
January 15, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29333321/periodontal-wound-healing-following-reciprocal-autologous-root-transplantation-in-class-iii-furcation-defects
#4
Naoshi Takeuchi, Yoshinori Shirakata, Yukiya Shinohara, Kotaro Sena, Kazuyuki Noguchi
Purpose: Furcation involvement in the molars is difficult to treat, and has been recognized as a risk factor for tooth loss. Although periodontal regenerative therapies, including guided tissue regeneration and various types of bone grafts, have been applied to furcation defects, the effects of these treatments are limited, especially in large class III furcation defects. The purpose of this pilot study was to investigate the effect of reciprocal autologous root transplantation on periodontal wound healing and regeneration in class III furcation defects in dogs...
December 2017: Journal of Periodontal & Implant Science
https://www.readbyqxmd.com/read/29330037/sustained-delivery-of-glial-cell-derived-neurotrophic-factors-in-collagen-conduits-for-facial-nerve-regeneration
#5
Fukai Ma, Feng Xu, Ronggang Li, Yongtao Zheng, Fan Wang, Naili Wei, Junjie Zhong, Qisheng Tang, Tongming Zhu, Zhifu Wang, Jianhong Zhu
Facial nerve injury caused by traffic accidents or operations may reduce the quality of life in patients, and recovery following the injury presents unique clinical challenges. Glial cell-derived neurotrophic factor (GDNF) is important in nerve regeneration; however, soluble GDNF rapidly diffuses into body fluids, making it difficult to achieve therapeutic efficacy. In this work, we developed a rat tail derived collagen conduit to connect nerve defects in a simple and safe manner. GDNF was immobilized in the collagen conduits via chemical conjugation to enable controlled release of GDNF...
January 9, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29329642/mesenchymal-stem-cell-macrophage-crosstalk-and-bone-healing
#6
Jukka Pajarinen, Tzuhua Lin, Emmanuel Gibon, Yusuke Kohno, Masahiro Maruyama, Karthik Nathan, Laura Lu, Zhenyu Yao, Stuart B Goodman
Recent research has brought about a clear understanding that successful fracture healing is based on carefully coordinated cross-talk between inflammatory and bone forming cells. In particular, the key role that macrophages play in the recruitment and regulation of the differentiation of mesenchymal stem cells (MSCs) during bone regeneration has been brought to focus. Indeed, animal studies have comprehensively demonstrated that fractures do not heal without the direct involvement of macrophages. Yet the exact mechanisms by which macrophages contribute to bone regeneration remain to be elucidated...
January 2, 2018: Biomaterials
https://www.readbyqxmd.com/read/29327429/in-vivo-migration-of-endogenous-brain-progenitor-cells-guided-by-an-injectable-peptide-amphiphile-biomaterial
#7
Reza Motalleb, Eric J Berns, Piyush Patel, Julie Gold, Samuel I Stupp, H Georg Kuhn
Biomaterials hold great promise in helping the adult brain regenerate and rebuild after trauma. Peptide amphiphiles (PA) are highly versatile biomaterials, gelling and forming macromolecular structures when exposed to physiological levels of electrolytes. We are here reporting on the first ever in vivo use of self-assembling peptide amphiphile carrying a Tenascin-C signal (E2 Ten-C PA) for the re-direction of endogenous neuroblasts in the rodent brain. The PA forms highly aligned nanofibers, displaying the migratory sequence of Tenascin-C glycoprotein as epitope...
January 12, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29322600/using-enamel-matrix-derivative-to-improve-treatment-efficacy-in-periodontal-furcation-defects
#8
REVIEW
Reza Masaeli, Kavosh Zandsalimi, Zahra Lotfi, Lobat Tayebi
PURPOSE: Furcations are complicated periodontal defects. Untreated furcations lead to loss of the involved teeth and supporting tissues. It has been demonstrated that regenerative biomaterials are beneficial in reconstruction of the bone surrounding furcation-affected teeth. These biomaterials range from bone grafts and nonresorbable/resorbable barrier membranes to biologics that are able to trigger inactive regenerative processes in periodontal tissues. Selection of appropriate material(s) to treat furcations is challenging...
January 11, 2018: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29310906/development-of-layered-plga-membranes-for-periodontal-tissue-regeneration
#9
Itsumi Yoshimoto, Jun-Ichi Sasaki, Ririko Tsuboi, Satoshi Yamaguchi, Haruaki Kitagawa, Satoshi Imazato
OBJECTIVE: Various commercial products are available for guided tissue regeneration (GTR) therapy; however, they do not combine biosafety with the ability to control cell function. The purpose of this study was to evaluate the physicochemical and biological characteristics of the novel bilayer biodegradable poly(lactic-co-glycolic acid) (PLGA) membrane, and to assess whether the bilayer PLGA membrane could be used for periodontal tissue regeneration. METHODS: Bilayer biodegradable membrane was fabricated thorough a two-step freezing and lyophilization process using PLGA solution...
January 5, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29303409/clinical-evaluation-of-a-new-synthetic-resorbable-dental-membrane-a-case-series-study
#10
Hélène Martin Thomé, David Bourdin, Nicolas Strube, Afchine Saffarzadeh, Jean-Francois Morlock, Guillaume Campard, Charles Evanno, Alain Hoornaert, Pierre Layrolle
For the regeneration of small osseous defects, dental membranes are commonly used in oral and maxillofacial surgery. A new synthetic resorbable membrane has recently demonstrated its biocompatibility and bone regeneration capacity in preclinical studies. This membrane is made of poly-D,L-lactic/glycolic acid 85/15 (PLGA), has a bi-layered structure with a dense film to prevent gingival epithelial cell invasion and a micro-fibrous layer to support osteogenic cells and bone healing. This membrane completely degrades by hydrolysis in 4 to 6 months without signs of inflammation...
January 5, 2018: Journal of Oral Implantology
https://www.readbyqxmd.com/read/29295498/bmp-signalling-at-the-crossroad-of-liver-fibrosis-and-regeneration
#11
REVIEW
Blanca Herrera, Annalisa Addante, Aránzazu Sánchez
Bone Morphogenetic Proteins (BMPs) belong to the Transforming Growth Factor-β (TGF-β) family. Initially identified due to their ability to induce bone formation, they are now known to have multiple functions in a variety of tissues, being critical not only during development for tissue morphogenesis and organogenesis but also during adult tissue homeostasis. This review focus on the liver as a target tissue for BMPs actions, devoting most efforts to summarize our knowledge on their recently recognized and/or emerging roles on regulation of the liver regenerative response to various insults, either acute or chronic and their effects on development and progression of liver fibrosis in different pathological conditions...
December 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29289707/periodontal-materials-and-cell-biology-for-guided-tissue-and-bone-regeneration
#12
REVIEW
Mihai Andrei, Anca Dinischiotu, Andreea Cristiana Didilescu, Daniela Ionita, Ioana Demetrescu
The present review is intended to find links between periodontal materials of the dentomaxillary apparatus and cell biology at the beginning of a century fraught with various forms of periodontal diseases and needing new treatment strategies. The manuscript has two different parts. The first describes the anatomy of tooth supporting structures, as well as related pathologies. The second part is related to cell and molecular biology in the context of periodontal regeneration.
December 28, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29285337/management-of-the-exposure-of-a-dense-ptfe-d-ptfe-membrane-in-guided-bone-regeneration-gbr-a-case-report
#13
P Ghensi, W Stablum, E Bettio, M C Soldini, T R Tripi, C Soldini
Guided bone regeneration (GBR) is a well-established and generally predictable method for repairing alveolar ridge defects and preparing edentulous sites for implant placement. Standard GBR involves filling the space underneath a membrane with autogenous bone or a mixture composed of autogenous bone particles and allogeneic bone tissue or heterologous biomaterials. The use of a barrier membrane for GBR has sometimes been associated with complications, however - reportedly involving exposure, infection, and collapse - and the non-resorbable types of membrane seem to be involved more often than the resorbable solutions...
July 2017: Oral & Implantology
https://www.readbyqxmd.com/read/29284978/successful-surgical-management-of-palatogingival-groove-using-platelet-rich-fibrin-and-guided-tissue-regeneration-a-novel-approach
#14
J V Karunakaran, Susan Mathew Fenn, N Jayaprakash, N Ragavendran
Palatogingival groove also known as radicularlingual groove is a developmental anomaly involving the lingual surface of the maxillary incisors. They are inconspicuous, funnel-shaped, extend for varying distances on root surface and occur due to infolding of the hertwigs epithelial root sheath. This encourages adherence of microorganisms and plaque to levels significant for pathological changes resulting in endodontic and periodontal lesions. The variations in anatomy of the tooth as a cause of pulp necrosis in teeth of anterior maxillary segment should be considered by the clinician when other etiological factors are ruled out...
November 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29284960/assessment-of-regeneration-of-bone-in-the-extracted-third-molar-sockets-augmented-using-xenograft-collaplugtn-zimmer-in-comparison-with-the-normal-healing-on-the-contralateral-side
#15
Murugan Ranganathan, M Balaji, R Krishnaraj, Vivek Narayanan, Annamalai Thangavelu
Introduction: Alveolar bone resorption is a significant clinical problem. Bone loss in third molar region following extraction or surgical removal not only leads to periodontal problems in second molar region but also it may lead to some serious problems like increased incidence of angle fractures. In order to reduce the risks following third molar surgery, the socket should be augmented with bone grafts. In recent days guided tissue regeneration is the most accepted and successful technique followed many authors and its efficacy has been proved...
November 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29283207/hard-tissue-volume-stability-of-guided-bone-regeneration-during-the-healing-stage-in-the-anterior-maxilla-a-clinical-and-radiographic-study
#16
Xi Jiang, Yu Zhang, Ping Di, Ye Lin
BACKGROUND: Guided bone regeneration (GBR) is currently the most widely used technique to reconstruct localized peri-implant bone defects. OBJECTIVES: To evaluate hard tissue volume stability during the healing stage of GBR with particulate bone graft and resorbable collagen membrane. MATERIALS AND METHODS: Twenty-eight patients who were missing a single maxillary incisor and required implant placement combined with GBR were randomly assigned to 2 groups: submerged (n = 14) and transmucosal (n = 14) healing groups...
December 28, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/29247452/influence-of-autogenous-platelet-concentrate-on-combined-gtr-graft-therapy-in-intrabony-defects-a-13-year-follow-up-of-a-randomized-controlled-clinical-split-mouth-study
#17
Fabian Cieplik, Laura Tabenski, Karl-Anton Hiller, Gottfried Schmalz, Wolfgang Buchalla, Michael Christgau
AIM: To investigate the clinical long-term outcomes 13 years following guided tissue regeneration (GTR) in deep intrabony defects with and without additional application of autogenous platelet concentrate (APC). METHODS: In 25 patients, two deep contra-lateral intrabony defects were treated according to GTR using ß-TCP and bio-resorbable membranes. In test defects, APC was applied additionally. After 13 years, clinical healing results were assessed and compared to results at baseline and after 1 year...
December 15, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29247167/shear-induced-notch-cx37-p27-axis-arrests-endothelial-cell-cycle-to-enable-arterial-specification
#18
Jennifer S Fang, Brian G Coon, Noelle Gillis, Zehua Chen, Jingyao Qiu, Thomas W Chittenden, Janis M Burt, Martin A Schwartz, Karen K Hirschi
Establishment of a functional vascular network is rate-limiting in embryonic development, tissue repair and engineering. During blood vessel formation, newly generated endothelial cells rapidly expand into primitive plexi that undergo vascular remodeling into circulatory networks, requiring coordinated growth inhibition and arterial-venous specification. Whether the mechanisms controlling endothelial cell cycle arrest and acquisition of specialized phenotypes are interdependent is unknown. Here we demonstrate that fluid shear stress, at arterial flow magnitudes, maximally activates NOTCH signaling, which upregulates GJA4 (commonly, Cx37) and downstream cell cycle inhibitor CDKN1B (p27)...
December 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/29241032/biomimetic-elastomeric-conductive-and-biodegradable-polycitrate-based-nanocomposites-for-guiding-myogenic-differentiation-and-skeletal-muscle-regeneration
#19
Yuzhang Du, Juan Ge, Yannan Li, Peter X Ma, Bo Lei
Artificial muscle-like biomaterials have gained tremendous interests owing to their broad applications in regenerative medicine, wearable devices, bioelectronics and artificial intelligence. Unfortunately, key challenges are still existed for current materials, including biomimetic viscoelasticity, biocompatibility and biodegradation, multifunctionality. Herein, for the first time, we develop highly elastomeric, conductive and biodegradable poly (citric acid-octanediol-polyethylene glycol)(PCE)-graphene (PCEG) nanocomposites, and demonstrate their applications in myogenic differentiation and guiding skeletal muscle tissue regeneration...
December 6, 2017: Biomaterials
https://www.readbyqxmd.com/read/29238373/guided-tissue-regeneration-and-platelet-rich-growth-factor-for-the-treatment-of-grade-ii-furcation-defects-a-randomized-double-blinded-clinical-trial-a-pilot-study
#20
Niloofar Jenabian, Sina Haghanifar, Hodis Ehsani, Ehsan Zahedi, Masumeh Haghpanah
Background: The treatment of furcation area defects remained as a challenging issue in periodontal treatments. Regeneration treatment of furcation defects is the most discussed periodontal treatment. Although not completely hopeless in prognosis, the presence of the furcation involvement significantly increases the chance of tooth loss. The current research was conductedeto compare theeadditive effect of combined guided tissue regeneration (GTR) and platelet-rich growth factor (PRGF) on the treatment of furcation bony defects...
November 2017: Dental Research Journal
keyword
keyword
42687
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"