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https://www.readbyqxmd.com/read/28510800/structural-modulation-of-gut-microbiota-in-bama-minipigs-in-response-to-treatment-with-a-growth-promoting-agent-salbutamol
#1
Chenyang Lu, Jun Zhou, Yanyan Li, Dijun Zhang, Zuzhong Wang, Ye Li, Lingzhi Cheong, Chundan Zhang, Xiurong Su
Even though salbutamol (SAL) had remarkable effects on the enhancement of growth rate and carcass composition in different livestock species such as cattle, pigs, sheep and poultry, it was banned as a growth promoter because of its adverse effects on health. However, the specific mechanism by which salbutamol enhances growth efficiency remains unknown. In this study, Bama pigs were randomly allocated to receive salbutamol (5 mg/kg) for 30 or 60 days and were compared with untreated pigs. Pigs treated with salbutamol demonstrated enhanced growth rates and carcass composition; however, they showed deterioration in blood biochemical indices and organ development...
May 16, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28501689/obtaining-titanium-dioxide-nanoparticles-with-spherical-shape-and-antimicrobial-properties-using-m-citrifolia-leaves-extract-by-hydrothermal-method
#2
Sundrarajan M, Bama K, Bhavani M, Jegatheeswaran S, Ambika S, Sangili A, Nithya P, Sumathi R
In this work, we synthesized titanium dioxide (TiO2) nanoparticles using leaf extract of Morinda citrifolia (M. citrifolia) by the advanced hydrothermal method. The synthesized TiO2 nanoparticles were characterized by X-ray diffraction (XRD), Fourier transmission infrared (FT-IR), Ultraviolet-visible diffuse reflectance (UV-Vis DRS), Ultraviolet-visible spectroscopy (UV-Vis), Raman spectroscopy, and scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM with EDX) techniques. The XRD major peak at 27...
May 3, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28496441/discovery-of-novel-leptospirosis-vaccine-candidates-using-reverse-and-structural-vaccinology
#3
André Alex Grassmann, Frederico Schmitt Kremer, Júlia Cougo Dos Santos, Jéssica Dias Souza, Luciano da Silva Pinto, Alan John Alexander McBride
Leptospira spp. are diderm (two membranes) bacteria that infect mammals causing leptospirosis, a public health problem with global implications. Thousands of people die every year due to leptospirosis, especially in developing countries with tropical climates. Prophylaxis is difficult due to multiple factors, including the large number of asymptomatic hosts that transmit the bacteria, poor sanitation, increasing numbers of slum dwellers, and the lack of an effective vaccine. Several leptospiral recombinant antigens were evaluated as a replacement for the inactivated (bacterin) vaccine; however, success has been limited...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28486585/cold-adaptation-in-pigs-depends-on-ucp3-in-beige-adipocytes
#4
Jun Lin, Chunwei Cao, Cong Tao, Rongcai Ye, Meng Dong, Qiantao Zheng, Chao Wang, Xiaoxiao Jiang, Guosong Qin, Changguo Yan, Kui Li, John R Speakman, Yanfang Wang, Wanzhu Jin, Jianguo Zhao
Pigs lack functional UCP1 making them susceptible to cold. Nevertheless, several pig breeds are known to be cold resistant. The molecular mechanism(s) enabling such adaptation are currently unknown. Here, we show that this resistance is not dependent on shivering, but rather depends on UCP3 and white adipose tissue (WAT) browning. In two cold-resistant breeds (Tibetan and Min), but not a cold-sensitive breed (Bama), WAT browning was induced after cold exposure. Beige adipocytes from Tibetan pigs exhibited greater oxidative capacity than those from Bama pigs...
May 9, 2017: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/28486432/apolipoprotein-c-i-polymorphism-and-its-association-with-serum-lipid-levels-and-longevity-in-the-bama-population
#5
You Li, Yongquan Huang, Xue Liang, Bingshuang Long, Shiyi Chen, Jiahao Lian, Yi Wei, Zhiyong Zhang, Jian Qin
This study aims to determine the association between the apolipoprotein C-I polymorphism and the longevity and genetic variants in ApoC-I that can influence the serum lipid levels in Bama. ApoC-I genotypes were determined by Taqman single nucleotide polymorphism (SNP) genotyping assays in 178 long-lived inhabitants (longevity group aged from 90 to 110 years), 147 healthy controls (Control 1 group aged from 40 to 79 years old) from Bama County, and 190 healthy controls (Control 2 group aged from 40 to 79 years old) from Nandan County without a family history of longevity...
May 9, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28484799/distribution-of-anaerobic-hydrocarbon-degrading-bacteria-in-soils-from-king-george-island-maritime-antarctica
#6
Dayanna Souza Sampaio, Juliana Rodrigues Barboza Almeida, Hugo E de Jesus, Alexandre S Rosado, Lucy Seldin, Diogo Jurelevicius
Anaerobic diesel fuel Arctic (DFA) degradation has already been demonstrated in Antarctic soils. However, studies comparing the distribution of anaerobic bacterial groups and of anaerobic hydrocarbon-degrading bacteria in Antarctic soils containing different concentrations of DFA are scarce. In this study, functional genes were used to study the diversity and distribution of anaerobic hydrocarbon-degrading bacteria (bamA, assA, and bssA) and of sulfate-reducing bacteria (SRB-apsR) in highly, intermediate, and non-DFA-contaminated soils collected during the summers of 2009, 2010, and 2011 from King George Island, Antarctica...
May 8, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/28465483/crispr-cas9-mediated-apoe-and-ldlr-double-gene-knockout-in-pigs-elevates-serum-ldl-c-and-tc-levels
#7
Lei Huang, Zaidong Hua, Hongwei Xiao, Ying Cheng, Kui Xu, Qian Gao, Ying Xia, Yang Liu, Xue Zhang, Xinming Zheng, Yulian Mu, Kui Li
The traditional method to establish a cardiovascular disease model induced by high fat and high cholesterol diets is time consuming and laborious and may not be appropriate in all circumstances. A suitable pig model to study metabolic disorders and subsequent atherosclerosis is not currently available. For this purpose, we applied the CRISPR/Cas9 system to Bama minipigs, targeting apolipoprotein E (ApoE) and low density lipoprotein receptor (LDLR) gene simultaneously. Six biallelic knockout pigs of these two genes were obtained successfully in a single step...
April 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423886/adiponectin-induced-ampk-impairment-mediates-insulin-resistance-in-bama-mini-pig-fed-high-fat-and-high-sucrose-diet
#8
Miaomiao Niu, Lei Xiang, Yaqian Liu, Yuqiong Zhao, Jifang Yuan, Xin Dai, Hua Chen
Objective: Adipose tissue is no longer considered as an inert storage organ for lipid, but instead is thought to play an active role in regulating insulin effects via secretion adipokines. However, conflicting reports have emerged regarding the effects of adipokines. In this study, we investigated the role of adipokines in glucose metabolism and insulin sensitivity in obese Bama mini-pigs. Methods: An obesity model was established in Bama mini-pigs, by feeding with high-fat and high-sucrose diet for 30 weeks...
March 25, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28411074/low-dose-sustained-release-deoxycorticosterone-acetate-induced-hypertension-in-bama-miniature-pigs-for-renal-sympathetic-nerve-denervation
#9
Wenzheng Han, Weiyi Fang, Qian Gan, Shaofeng Guan, Yanjie Li, Ming Wang, Kaizheng Gong, Xinkai Qu
Recently, the effectiveness of renal sympathetic nerve denervation for treatment of hypertension has been doubted after SYMPLICITY HTN-3 trial. An ideal animal model is still unavailable for preclinical study about catheter-based renal sympathetic nerve denervation for treatment of hypertension. Traditional high-dose deoxycorticosterone acetate (DOCA)-induced hypertension pig model has some problems due to extensive end-organ damage. Based on the similarity in the anatomic characteristics of renal artery between pigs and humans, this study was undertaken to establish a low-dose sustained-release DOCA-induced hypertension model in pigs...
March 2, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28411032/a-2-bp-insertion-c-67_68inscc-in-mc1r-causes-recessive-white-coat-color-in-bama-miniature-pigs
#10
LETTER
Qitao Jia, Chunwei Cao, Hai Tang, Ying Zhang, Qiantao Zheng, Xiao Wang, Rui Zhang, Xianlong Wang, Ailing Luo, Hong Wei, Anming Meng, Qi Zhou, Hongmei Wang, Jianguo Zhao
No abstract text is available yet for this article.
April 20, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28397982/generation-of-chimeric-minipigs-by-aggregating-4-to-8-cell-stage-blastomeres-from-somatic-cell-nuclear-transfer-with-the-tracing-of-enhanced-green-fluorescent-protein
#11
Huili Ji, Chuan Long, Chong Feng, Ningning Shi, Yingdi Jiang, Guomin Zeng, Xirui Li, Jingjing Wu, Lin Lu, Shengsheng Lu, Dengke Pan
BACKGROUND: Blastocyst complementation is an important technique for generating chimeric organs in organ-deficient pigs, which holds great promise for solving the problem of a shortage of organs for human transplantation procedures. Porcine chimeras have been generated using embryonic germ cells, embryonic stem cells, and induced pluripotent stem cells; however, there are no authentic pluripotent stem cells for pigs. In previous studies, blastomeres from 4- to 8-cell-stage parthenogenetic embryos were able to generate chimeric fetuses efficiently, but the resulting fetuses did not produce live-born young...
April 11, 2017: Xenotransplantation
https://www.readbyqxmd.com/read/28396274/acellular-dermal-matrix-for-esophageal-stricture-prevention-after-endoscopic-submucosal-dissection-in-a-porcine-model
#12
Ye Han, Jintao Guo, Siyu Sun, Weichao Wu, Sheng Wang, Nan Ge, Xiang Liu, Guoxin Wang, Shupeng Wang
BACKGROUND AND AIMS: Endoscopic submucosal dissection (ESD) is considered an effective treatment for early esophageal cancer and precancerous lesions. Esophageal stenosis is closely associated with quasi-circumferential ESD. We examined whether post-ESD esophageal stricture can be prevented by grafting an acellular dermal matrix (ADM) membrane. METHODS: Fourteen Bama miniature pigs were randomly divided into an ADM group (n = 7) and a control group (n = 7). Semicircumferential ESD was performed at the distal esophagus in all animals, and in the ADM group an ADM patch graft was placed at the resection site and secured innovatively with metal clips...
April 8, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28369150/isolation-and-characterization-of-magnetospirillum-sp-strain-15-1-as-a-representative-anaerobic-toluene-degrader-from-a-constructed-wetland-model
#13
Ingrid Meyer-Cifuentes, Paula M Martinez-Lavanchy, Vianey Marin-Cevada, Stefanie Böhnke, Hauke Harms, Jochen A Müller, Hermann J Heipieper
Previously, Planted Fixed-Bed Reactors (PFRs) have been used to investigate microbial toluene removal in the rhizosphere of constructed wetlands. Aerobic toluene degradation was predominant in these model systems although bulk redox conditions were hypoxic to anoxic. However, culture-independent approaches indicated also that microbes capable of anaerobic toluene degradation were abundant. Therefore, we aimed at isolating anaerobic-toluene degraders from one of these PFRs. From the obtained colonies which consisted of spirilli-shaped bacteria, a strain designated 15-1 was selected for further investigations...
2017: PloS One
https://www.readbyqxmd.com/read/28366826/a-natural-product-from-cannabis-sativa-subsp-sativa-inhibits-homeodomain-interacting-protein-kinase-2-hipk2-attenuating-mpp-induced-apoptosis-in-human-neuroblastoma-sh-sy5y-cells
#14
Guan Wang, Lingjuan Zhu, Yuqian Zhao, Suyu Gao, Dejuan Sun, Jingquan Yuan, Yuxin Huang, Xue Zhang, Xinsheng Yao
Homeodomain-interacting protein kinase 2 (HIPK2) is a conserved serine/threonine kinase, which regulate transcription, cell differentiation, proliferation and apoptosis. Previous evidences indicated that HIPK2 could be involved in the pathogenesis of neurodegenerative diseases, suggesting as a novel target for Parkinson's disease (PD) therapeutic development. Herein, gene microarray analysis was performed to verify the key regulatory function of HIPK2 in PD. (Z)-methylp-hydroxycinnamate (ZMHC, 7) with other eighteen compounds were isolated from Cannabis sativa subsp...
March 30, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28351921/cdia-effectors-use-modular-receptor-binding-domains-to-recognize-target-bacteria
#15
Zachary C Ruhe, Josephine Y Nguyen, Jing Xiong, Sanna Koskiniemi, Christina M Beck, Basil R Perkins, David A Low, Christopher S Hayes
Contact-dependent growth inhibition (CDI) systems encode CdiA effectors, which bind to specific receptors on neighboring bacteria and deliver C-terminal toxin domains to suppress target cell growth. Two classes of CdiA effectors that bind distinct cell surface receptors have been identified, but the molecular basis of receptor specificity is not understood. Alignment of BamA-specific CdiA(EC93) from Escherichia coli EC93 and OmpC-specific CdiA(EC536) from E. coli 536 suggests that the receptor-binding domain resides within a central region that varies between the two effectors...
March 28, 2017: MBio
https://www.readbyqxmd.com/read/28339502/histological-and-anatomical-structure-of-the-nasal-cavity-of-bama-minipigs
#16
Jingjing Yang, Lei Dai, Qinghua Yu, Qian Yang
OBJECTIVE: The nasal mucosa is equipped with abundant lymphatic tissues, serving as the first line of defense against invasion by microorganisms. In this study, we characterized the features of the nasal mucosa of Bama minipigs (Sus scrofa domestica) via histological analysis. METHODS: Five cross sections (I, II, III, IV, and V) were obtained from the distal end of the nasal cavity toward the pharynx (along the cavity axis) and examined. Specifically, CD3+ T cells, immunoglobulin A (IgA)+ cells, and M cells were detected by immunohistochemistry, while dendritic cells (DCs) were detected by immunofluorescence...
2017: PloS One
https://www.readbyqxmd.com/read/28255340/phenytoin-silver-a-new-nanocompound-for-promoting-dermal-wound-healing-via-comprehensive-pharmacological-action
#17
Xiao-Yu Ai, Hui-Juan Liu, Cheng Lu, Cai-Li Liang, Yan Sun, Shuang Chen, Bo Sun, Yang Li, Yan-Rong Liu, Qiang Zhang, Xue-Qiang Liu, Ting Xiao, Xue-Shuang Jing, Tao Sun, Hong-Gang Zhou, Cheng Yang
Phenytoin, an antiepileptic drug, has been widely used for wound healing. Inspired by previous studies, phenytoin silver (PnAg), a sparingly soluble silver nanocompound, was synthesized which exhibited good therapeutic efficacy in tissue repair with low toxicity (LD50 >5 g/kg). In vivo studies showed that PnAg could accelerate dermal wound healing and strong inflammation control in Sprague-Dawley rats (SD rat) and Bama minipigs. Due to its low solubility, PnAg led to low toxicity and blood enrichment in animals...
2017: Theranostics
https://www.readbyqxmd.com/read/28223520/membrane-integration-of-an-essential-%C3%AE-barrel-protein-prerequires-burial-of-an-extracellular-loop
#18
Joseph S Wzorek, James Lee, David Tomasek, Christine L Hagan, Daniel E Kahne
The Bam complex assembles β-barrel proteins into the outer membrane (OM) of Gram-negative bacteria. These proteins comprise cylindrical β-sheets with long extracellular loops and create pores to allow passage of nutrients and waste products across the membrane. Despite their functional importance, several questions remain about how these proteins are assembled into the OM after their synthesis in the cytoplasm and secretion across the inner membrane. To understand this process better, we studied the assembly of an essential β-barrel substrate for the Bam complex, BamA...
March 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28216659/the-%C3%AE-barrel-assembly-machinery-in-motion
#19
REVIEW
Nicholas Noinaj, James C Gumbart, Susan K Buchanan
In Gram-negative bacteria, the biogenesis of β-barrel outer membrane proteins (OMPs) is mediated by the β-barrel assembly machinery (BAM) complex. During the past decade, structural and functional studies have collectively contributed to advancing our understanding of the structure and function of the BAM complex; however, the exact mechanism that is involved remains elusive. In this Progress article, we discuss recent structural studies that have revealed that the accessory proteins may regulate essential unprecedented conformational changes in the core component BamA during function...
April 2017: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/28174029/effect-of-dietary-zinc-on-morphological-characteristics-and-apoptosis-related-gene-expression-in-the-small-intestine-of-bama-miniature-pigs
#20
Xin Zhou, Yansen Li, Zhaojian Li, Yun Cao, Fei Wang, ChunMei Li
To investigate the effects of dietary zinc (Zn) on small intestinal mucosal epithelium, 6-month-old male Bama miniature pigs were randomly allocated into three groups and treated with three levels of Zn (Control, T1, and T2 diet supplemented with 0, 50, and 1500mg/kg Zn, respectively, as zinc sulfate) for 38days. The samples of small intestine tissues, serum, and feces were collected. The results showed that Zn concentrations of small intestine in the T2 group were higher than those in the control and T1 groups (p<0...
February 4, 2017: Acta Histochemica
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