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https://www.readbyqxmd.com/read/28715930/transcription-analysis-of-cochlear-development-in-minipigs
#1
Qinghua Wang, Yan Zhang, Weiwei Guo, Yu Liu, Hong Wei, Shiming Yang
CONCLUSIONS: The critical stage for cochlear gene regulation in the embryo is E49-E56. These data provide a valuable resource to help elucidate gene regulation in cochlear development and will benefit ear-related studies, especially those that focus on gene and stem cell therapies in hearing loss. OBJECTIVES: To investigate gene regulation in cochlear development and provide reference information for ear-related research. METHODS: Total RNA extraction from the Bama miniature pig cochlea was performed at five time points that covered most of the cochlea development process (E42, E49, E56, E91, P13)...
July 18, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28713344/outer-membrane-proteome-of-veillonella-parvula-a-diderm-firmicute-of-the-human-microbiome
#2
Daniel I Poppleton, Magalie Duchateau, Véronique Hourdel, Mariette Matondo, Jennifer Flechsler, Andreas Klingl, Christophe Beloin, Simonetta Gribaldo
Veillonella parvula is a biofilm-forming commensal found in the lungs, vagina, mouth, and gastro-intestinal tract of humans, yet it may develop into an opportunistic pathogen. Furthermore, the presence of Veillonella has been associated with the development of a healthy immune system in infants. Veillonella belongs to the Negativicutes, a diverse clade of bacteria that represent an evolutionary enigma: they phylogenetically belong to Gram-positive (monoderm) Firmicutes yet maintain an outer membrane (OM) with lipopolysaccharide similar to classic Gram-negative (diderm) bacteria...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28702706/metagenomic-analysis-of-subtidal-sediments-from-polar-and-subpolar-coastal-environments-highlights-the-relevance-of-anaerobic-hydrocarbon-degradation-processes
#3
Fernando Espínola, Hebe M Dionisi, Sharon Borglin, Colin J Brislawn, Janet K Jansson, Walter P Mac Cormack, JoLynn Carroll, Sara Sjöling, Mariana Lozada
In this work, we analyzed the community structure and metabolic potential of sediment microbial communities in high-latitude coastal environments subjected to low to moderate levels of chronic pollution. Subtidal sediments from four low-energy inlets located in polar and subpolar regions from both Hemispheres were analyzed using large-scale 16S rRNA gene and metagenomic sequencing. Communities showed high diversity (Shannon's index 6.8 to 10.2), with distinct phylogenetic structures (<40% shared taxa at the Phylum level among regions) but similar metabolic potential in terms of sequences assigned to KOs...
July 12, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/28683436/effects-of-trimetazidine-on-pdcd4-nf-%C3%AE%C2%BAb-tnf-%C3%AE-pathway-in-coronary-microembolization
#4
Qiang Su, Lang Li, Jinmin Zhao, Yuhan Sun, Huafeng Yang
BACKGROUND/AIMS: The local inflammatory response caused by coronary microembolization (CME) is the primary cause of progressive cardiac dysfunction. The PDCD4/NF-κB/TNF-α signaling pathway plays a significant role in CME-induced myocardial Inflammation. Trimetazidine (TMZ) reduces myocardial injury, caused by percutaneous coronary intervention, through relieving the CME-induced myocardial systolic dysfunction. Therefore, the present study investigated the role of TMZ pre-treatment in the protection of myocardium after CME and PDCD4/NF-κB/TNF-α in mini pigs...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28674285/a-high-sucrose-and-high-fat-diet-induced-the-development-of-insulin-resistance-in-the-skeletal-muscle-of-bama-miniature-pigs-through-the-akt-glut4-pathway
#5
Yaqian Liu, Jifang Yuan, Lei Xiang, Yuqiong Zhao, Miaomiao Niu, Xin Dai, Hua Chen
A high sucrose and high fat (HSHF) diet induces insulin resistance (IR) and increased susceptibility to type 2 diabetes mellitus (T2DM), but the underlying mechanisms are poorly characterized. This study aimed to investigate the molecular mechanisms by which the HSHF diet impairs insulin sensitivity in Bama miniature pigs (sus scrofa domesticus). Twelve Bama miniature pigs were randomly assigned to the control diet (CD) group (n=6) or the HSHF group (n=6) for 6 months. Biochemical parameters were measured. Western blot, RT-qPCR and immunohistochemistry were used to profile the changes of protein expression, mRNA expression and glucose transporter 4 (GLUT4) expression in skeletal muscle tissues, respectively...
July 3, 2017: Experimental Animals
https://www.readbyqxmd.com/read/28672963/easapprox-%C3%A2-skin-stretching-system-a-secure-and-effective-method-to-achieve-wound-closure
#6
Mingzhi Song, Zhen Zhang, Tao Liu, Song Liu, Gang Li, Zhaochang Liu, Jingyang Huang, Song Chen, Linan Li, Li Guo, Yang Qiu, Jiajia Wan, Yuejian Liu, Tao Wu, Xiaoyong Wang, Ming Lu, Shouyu Wang
Large skin defects are commonly observed in the clinic and have attracted much attention recently. Therefore, finding an effective solution for large skin defects is a global problem. The objective of the present study was to assess the effectiveness of the EASApprox(®) skin-stretching system for closing large skin defects. Skin defects (5×5 cm) were created on the forearms of 9 Bama miniature pigs, which were randomly divided into the following three groups: Direct suture, the new EASApprox(®) skin-stretching device and Kirschner wires...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28630161/insertion-of-proteins-and-lipopolysaccharide-into-the-bacterial-outer-membrane
#7
REVIEW
Istvan Botos, Nicholas Noinaj, Susan K Buchanan
The bacterial outer membrane contains phospholipids in the inner leaflet and lipopolysaccharide (LPS) in the outer leaflet. Both proteins and LPS must be frequently inserted into the outer membrane to preserve its integrity. The protein complex that inserts LPS into the outer membrane is called LptDE, and consists of an integral membrane protein, LptD, with a separate globular lipoprotein, LptE, inserted in the barrel lumen. The protein complex that inserts newly synthesized outer-membrane proteins (OMPs) into the outer membrane is called the BAM complex, and consists of an integral membrane protein, BamA, plus four lipoproteins, BamB, C, D and E...
August 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28616917/-a-study-on-the-feasibility-to-assay-minipig-insulin-through-human-insulin-radioimmunoassay-kit
#8
Meng-Yu Yang, Yun-Yi Gao, Yan Li, Ya-Li Li, Hao Zhong, Xing-Wu Ran
OBJECTIVES: To investigate the feasibility of using human-specific insulin radioimmunoassay (Ins-RIA) kit to measure the concentrations of serum insulin in minipigs. METHODS: The Serum samples (219) of Bama minipigs were collected. The concentrations of serum insulin in Bama minipigs were measured by Ins-RIA kit and porcine-specific insulin enzyme linked immunosorbent assay (Ins-ELISA) kit, respectively. The linear regression analysis was undertaken in a randomly selected 175 samples (80% of total samples) to establish predictive equations between the concentrations of serum insulin measured by Ins-ELISA and the concentrations of serum insulin measured by Ins-RIA...
May 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28573043/a-safety-evaluation-of-profound-hypothermia-induced-suspended-animation-for-delayed-resuscitation-at-90-or-120%C3%A2-min
#9
Yu Liu, Shu Li, Zhi Li, Jian Zhang, Jin-Song Han, Yong Zhang, Zong-Tao Yin, Hui-Shan Wang
BACKGROUND: The successful treatment of military combat casualties with penetrating injuries is significantly dependent on the time needed to get the patient to an adequate treatment facility. Profound hypothermia-induced suspended animation for delayed resuscitation (SADR) is a novel approach for inducing cardiac arrest and buying additional time for such injuries. However, the time used to safely administer circulatory arrest (CA) is controversial. The goal of this study was to evaluate the safety of hypothermia-induced SADR over 90 and 120 min time intervals...
2017: Military Medical Research
https://www.readbyqxmd.com/read/28569500/extreme-dynamics-in-the-bama-%C3%AE-barrel-seam
#10
Pamela Arden Doerner, Marcelo C Sousa
BamA is an essential component of the β-barrel assembly machine (BAM) that is responsible for insertion and folding of β-barrel outer membrane proteins (OMPs) in Gram-negative bacteria. BamA is an OMP itself, and its β-barrel transmembrane domain is thought to catalyze OMP insertion and folding, although the molecular mechanism remains poorly understood. Crystal structures of BamA and complementary molecular dynamics simulations have shown that its β-barrel seam (the interface between the first and last barrel strands) is destabilized...
June 12, 2017: Biochemistry
https://www.readbyqxmd.com/read/28558932/bama-miniature-pigs-liver-possess-great-heat-tolerance-through-upregulation-of-nrf2-mediated-antioxidative-enzymes
#11
Jiaqin Chen, Fei Wang, Xin Zhou, Yun Cao, Yansen Li, Chunmei Li
The liver is one of the most crucial organs affected by high ambient temperature. Bama miniature pig show a heat tolerance in hot summer months. However, the physiological condition of liver under high ambient temperature has not been well elucidated in Bama miniature pig. Here we performed an experiment to investigate the effects of high ambient temperature on liver function, redox status and Nrf2 antioxidant pathway in Bama miniature pigs. Twelve pigs were randomly divided into two groups and separately exposed to the neutral temperature (NT, 25°C) and high temperature (HT, 40°C) for 8 days...
July 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28510800/structural-modulation-of-gut-microbiota-in-bama-minipigs-in-response-to-treatment-with-a-growth-promoting-agent-salbutamol
#12
Chenyang Lu, Jun Zhou, Yanyan Li, Dijun Zhang, Zuzhong Wang, Ye Li, Lingzhi Cheong, Chundan Zhang, Xiurong Su
Even though salbutamol (SAL) had remarkable effects on the enhancement of growth rate and carcass composition in different livestock species such as cattle, pigs, sheep and poultry, it was banned as a growth promoter because of its adverse effects on health. However, the specific mechanism by which salbutamol enhances growth efficiency remains unknown. In this study, Bama pigs were randomly allocated to receive salbutamol (5 mg/kg) for 30 or 60 days and were compared with untreated pigs. Pigs treated with salbutamol demonstrated enhanced growth rates and carcass composition; however, they showed deterioration in blood biochemical indices and organ development...
May 16, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28501689/obtaining-titanium-dioxide-nanoparticles-with-spherical-shape-and-antimicrobial-properties-using-m-citrifolia-leaves-extract-by-hydrothermal-method
#13
Sundrarajan M, Bama K, Bhavani M, Jegatheeswaran S, Ambika S, Sangili A, Nithya P, Sumathi R
In this work, we synthesized titanium dioxide (TiO2) nanoparticles using leaf extract of Morinda citrifolia (M. citrifolia) by the advanced hydrothermal method. The synthesized TiO2 nanoparticles were characterized by X-ray diffraction (XRD), Fourier transmission infrared (FT-IR), Ultraviolet-visible diffuse reflectance (UV-Vis DRS), Ultraviolet-visible spectroscopy (UV-Vis), Raman spectroscopy, and scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM with EDX) techniques. The XRD major peak at 27...
June 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28496441/discovery-of-novel-leptospirosis-vaccine-candidates-using-reverse-and-structural-vaccinology
#14
André Alex Grassmann, Frederico Schmitt Kremer, Júlia Cougo Dos Santos, Jéssica Dias Souza, Luciano da Silva Pinto, Alan John Alexander McBride
Leptospira spp. are diderm (two membranes) bacteria that infect mammals causing leptospirosis, a public health problem with global implications. Thousands of people die every year due to leptospirosis, especially in developing countries with tropical climates. Prophylaxis is difficult due to multiple factors, including the large number of asymptomatic hosts that transmit the bacteria, poor sanitation, increasing numbers of slum dwellers, and the lack of an effective vaccine. Several leptospiral recombinant antigens were evaluated as a replacement for the inactivated (bacterin) vaccine; however, success has been limited...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28486585/cold-adaptation-in-pigs-depends-on-ucp3-in-beige-adipocytes
#15
Jun Lin, Chunwei Cao, Cong Tao, Rongcai Ye, Meng Dong, Qiantao Zheng, Chao Wang, Xiaoxiao Jiang, Guosong Qin, Changguo Yan, Kui Li, John R Speakman, Yanfang Wang, Wanzhu Jin, Jianguo Zhao
Pigs lack functional UCP1 making them susceptible to cold. Nevertheless, several pig breeds are known to be cold resistant. The molecular mechanism(s) enabling such adaptation are currently unknown. Here, we show that this resistance is not dependent on shivering, but rather depends on UCP3 and white adipose tissue (WAT) browning. In two cold-resistant breeds (Tibetan and Min), but not a cold-sensitive breed (Bama), WAT browning was induced after cold exposure. Beige adipocytes from Tibetan pigs exhibited greater oxidative capacity than those from Bama pigs...
May 9, 2017: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/28486432/apolipoprotein-c-i-polymorphism-and-its-association-with-serum-lipid-levels-and-longevity-in-the-bama-population
#16
You Li, Yongquan Huang, Xue Liang, Bingshuang Long, Shiyi Chen, Jiahao Lian, Yi Wei, Zhiyong Zhang, Jian Qin
This study aims to determine the association between the apolipoprotein C-I polymorphism and the longevity and genetic variants in ApoC-I that can influence the serum lipid levels in Bama. ApoC-I genotypes were determined by Taqman single nucleotide polymorphism (SNP) genotyping assays in 178 long-lived inhabitants (longevity group aged from 90 to 110 years), 147 healthy controls (Control 1 group aged from 40 to 79 years old) from Bama County, and 190 healthy controls (Control 2 group aged from 40 to 79 years old) from Nandan County without a family history of longevity...
May 9, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28484799/distribution-of-anaerobic-hydrocarbon-degrading-bacteria-in-soils-from-king-george-island-maritime-antarctica
#17
Dayanna Souza Sampaio, Juliana Rodrigues Barboza Almeida, Hugo E de Jesus, Alexandre S Rosado, Lucy Seldin, Diogo Jurelevicius
Anaerobic diesel fuel Arctic (DFA) degradation has already been demonstrated in Antarctic soils. However, studies comparing the distribution of anaerobic bacterial groups and of anaerobic hydrocarbon-degrading bacteria in Antarctic soils containing different concentrations of DFA are scarce. In this study, functional genes were used to study the diversity and distribution of anaerobic hydrocarbon-degrading bacteria (bamA, assA, and bssA) and of sulfate-reducing bacteria (SRB-apsR) in highly, intermediate, and non-DFA-contaminated soils collected during the summers of 2009, 2010, and 2011 from King George Island, Antarctica...
May 8, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/28465483/crispr-cas9-mediated-apoe-and-ldlr-double-gene-knockout-in-pigs-elevates-serum-ldl-c-and-tc-levels
#18
Lei Huang, Zaidong Hua, Hongwei Xiao, Ying Cheng, Kui Xu, Qian Gao, Ying Xia, Yang Liu, Xue Zhang, Xinming Zheng, Yulian Mu, Kui Li
The traditional method to establish a cardiovascular disease model induced by high fat and high cholesterol diets is time consuming and laborious and may not be appropriate in all circumstances. A suitable pig model to study metabolic disorders and subsequent atherosclerosis is not currently available. For this purpose, we applied the CRISPR/Cas9 system to Bama minipigs, targeting apolipoprotein E (ApoE) and low density lipoprotein receptor (LDLR) gene simultaneously. Six biallelic knockout pigs of these two genes were obtained successfully in a single step...
June 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423886/adiponectin-induced-amp-activated-protein-kinase-impairment-mediates-insulin-resistance-in-bama-mini-pig-fed-high-fat-and-high-sucrose-diet
#19
Miaomiao Niu, Lei Xiang, Yaqian Liu, Yuqiong Zhao, Jifang Yuan, Xin Dai, Hua Chen
OBJECTIVE: Adipose tissue is no longer considered as an inert storage organ for lipid, but instead is thought to play an active role in regulating insulin effects via secretion adipokines. However, conflicting reports have emerged regarding the effects of adipokines. In this study, we investigated the role of adipokines in glucose metabolism and insulin sensitivity in obese Bama mini-pigs. METHODS: An obesity model was established in Bama mini-pigs, by feeding with high-fat and high-sucrose diet for 30 weeks...
August 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28411074/low-dose-sustained-release-deoxycorticosterone-acetate-induced-hypertension-in-bama-miniature-pigs-for-renal-sympathetic-nerve-denervation
#20
Wenzheng Han, Weiyi Fang, Qian Gan, Shaofeng Guan, Yanjie Li, Ming Wang, Kaizheng Gong, Xinkai Qu
Recently, the effectiveness of renal sympathetic nerve denervation for treatment of hypertension has been doubted after SYMPLICITY HTN-3 trial. An ideal animal model is still unavailable for preclinical study about catheter-based renal sympathetic nerve denervation for treatment of hypertension. Traditional high-dose deoxycorticosterone acetate (DOCA)-induced hypertension pig model has some problems due to extensive end-organ damage. Based on the similarity in the anatomic characteristics of renal artery between pigs and humans, this study was undertaken to establish a low-dose sustained-release DOCA-induced hypertension model in pigs...
March 2, 2017: Journal of the American Society of Hypertension: JASH
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