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https://www.readbyqxmd.com/read/28423886/adiponectin-induced-ampk-impairment-mediates-insulin-resistance-in-bama-mini-pig-fed-high-fat-and-high-sucrose-diet
#1
Miaomiao Niu, Lei Xiang, Yaqian Liu, Yuqiong Zhao, Jifang Yuan, Xin Dai, Hua Chen
Objective: Adipose tissue is no longer considered as an inert storage organ for lipid, but instead is thought to play an active role in regulating insulin effects via secretion adipokines. However, conflicting reports have emerged regarding the effects of adipokines. In this study, we investigated the role of adipokines in glucose metabolism and insulin sensitivity in obese Bama mini-pigs. Methods: An obesity model was established in Bama mini-pigs, by feeding with high-fat and high-sucrose diet for 30 weeks...
March 25, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28411074/low-dose-sustained-release-deoxycorticosterone-acetate-induced-hypertension-in-bama-miniature-pigs-for-renal-sympathetic-nerve-denervation
#2
Wenzheng Han, Weiyi Fang, Qian Gan, Shaofeng Guan, Yanjie Li, Ming Wang, Kaizheng Gong, Xinkai Qu
Recently, the effectiveness of renal sympathetic nerve denervation for treatment of hypertension has been doubted after SYMPLICITY HTN-3 trial. An ideal animal model is still unavailable for preclinical study about catheter-based renal sympathetic nerve denervation for treatment of hypertension. Traditional high-dose deoxycorticosterone acetate (DOCA)-induced hypertension pig model has some problems due to extensive end-organ damage. Based on the similarity in the anatomic characteristics of renal artery between pigs and humans, this study was undertaken to establish a low-dose sustained-release DOCA-induced hypertension model in pigs...
March 2, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28411032/a-2-bp-insertion-c-67_68inscc-in-mc1r-causes-recessive-white-coat-color-in-bama-miniature-pigs
#3
Qitao Jia, Chunwei Cao, Tang Hai, Ying Zhang, Qiantao Zheng, Xiao Wang, Rui Zhang, Xianlong Wang, Ailing Luo, Hong Wei, Anming Meng, Qi Zhou, Hongmei Wang, Jianguo Zhao
No abstract text is available yet for this article.
February 28, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28397982/generation-of-chimeric-minipigs-by-aggregating-4-to-8-cell-stage-blastomeres-from-somatic-cell-nuclear-transfer-with-the-tracing-of-enhanced-green-fluorescent-protein
#4
Huili Ji, Chuan Long, Chong Feng, Ningning Shi, Yingdi Jiang, Guomin Zeng, Xirui Li, Jingjing Wu, Lin Lu, Shengsheng Lu, Dengke Pan
BACKGROUND: Blastocyst complementation is an important technique for generating chimeric organs in organ-deficient pigs, which holds great promise for solving the problem of a shortage of organs for human transplantation procedures. Porcine chimeras have been generated using embryonic germ cells, embryonic stem cells, and induced pluripotent stem cells; however, there are no authentic pluripotent stem cells for pigs. In previous studies, blastomeres from 4- to 8-cell-stage parthenogenetic embryos were able to generate chimeric fetuses efficiently, but the resulting fetuses did not produce live-born young...
April 11, 2017: Xenotransplantation
https://www.readbyqxmd.com/read/28396274/acellular-dermal-matrix-for-esophageal-stricture-prevention-after-endoscopic-submucosal-dissection-in-a-porcine-model
#5
Ye Han, Jintao Guo, Siyu Sun, Weichao Wu, Sheng Wang, Nan Ge, Xiang Liu, Guoxin Wang, Shupeng Wang
BACKGROUND AND AIMS: Endoscopic submucosal dissection (ESD) is considered an effective treatment for early esophageal cancer and precancerous lesions. Esophageal stenosis is closely associated with quasi-circumferential ESD. We examined whether post-ESD esophageal stricture can be prevented by grafting an acellular dermal matrix (ADM) membrane. METHODS: Fourteen Bama miniature pigs were randomly divided into an ADM group (n=7) and a control group (n=7). Semi-circumferential ESD was performed at the distal esophagus in all animals, and in the ADM group, an ADM patch graft was placed at the resection site and secured innovatively with metal clips...
April 7, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28369150/isolation-and-characterization-of-magnetospirillum-sp-strain-15-1-as-a-representative-anaerobic-toluene-degrader-from-a-constructed-wetland-model
#6
Ingrid Meyer-Cifuentes, Paula M Martinez-Lavanchy, Vianey Marin-Cevada, Stefanie Böhnke, Hauke Harms, Jochen A Müller, Hermann J Heipieper
Previously, Planted Fixed-Bed Reactors (PFRs) have been used to investigate microbial toluene removal in the rhizosphere of constructed wetlands. Aerobic toluene degradation was predominant in these model systems although bulk redox conditions were hypoxic to anoxic. However, culture-independent approaches indicated also that microbes capable of anaerobic toluene degradation were abundant. Therefore, we aimed at isolating anaerobic-toluene degraders from one of these PFRs. From the obtained colonies which consisted of spirilli-shaped bacteria, a strain designated 15-1 was selected for further investigations...
2017: PloS One
https://www.readbyqxmd.com/read/28366826/a-natural-product-from-cannabis-sativa-subsp-sativa-inhibits-homeodomain-interacting-protein-kinase-2-hipk2-attenuating-mpp-induced-apoptosis-in-human-neuroblastoma-sh-sy5y-cells
#7
Guan Wang, Lingjuan Zhu, Yuqian Zhao, Suyu Gao, Dejuan Sun, Jingquan Yuan, Yuxin Huang, Xue Zhang, Xinsheng Yao
Homeodomain-interacting protein kinase 2 (HIPK2) is a conserved serine/threonine kinase, which regulate transcription, cell differentiation, proliferation and apoptosis. Previous evidences indicated that HIPK2 could be involved in the pathogenesis of neurodegenerative diseases, suggesting as a novel target for Parkinson's disease (PD) therapeutic development. Herein, gene microarray analysis was performed to verify the key regulatory function of HIPK2 in PD. (Z)-methylp-hydroxycinnamate (ZMHC, 7) with other eighteen compounds were isolated from Cannabis sativa subsp...
March 30, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28351921/cdia-effectors-use-modular-receptor-binding-domains-to-recognize-target-bacteria
#8
Zachary C Ruhe, Josephine Y Nguyen, Jing Xiong, Sanna Koskiniemi, Christina M Beck, Basil R Perkins, David A Low, Christopher S Hayes
Contact-dependent growth inhibition (CDI) systems encode CdiA effectors, which bind to specific receptors on neighboring bacteria and deliver C-terminal toxin domains to suppress target cell growth. Two classes of CdiA effectors that bind distinct cell surface receptors have been identified, but the molecular basis of receptor specificity is not understood. Alignment of BamA-specific CdiA(EC93) from Escherichia coli EC93 and OmpC-specific CdiA(EC536) from E. coli 536 suggests that the receptor-binding domain resides within a central region that varies between the two effectors...
March 28, 2017: MBio
https://www.readbyqxmd.com/read/28339502/histological-and-anatomical-structure-of-the-nasal-cavity-of-bama-minipigs
#9
Jingjing Yang, Lei Dai, Qinghua Yu, Qian Yang
OBJECTIVE: The nasal mucosa is equipped with abundant lymphatic tissues, serving as the first line of defense against invasion by microorganisms. In this study, we characterized the features of the nasal mucosa of Bama minipigs (Sus scrofa domestica) via histological analysis. METHODS: Five cross sections (I, II, III, IV, and V) were obtained from the distal end of the nasal cavity toward the pharynx (along the cavity axis) and examined. Specifically, CD3+ T cells, immunoglobulin A (IgA)+ cells, and M cells were detected by immunohistochemistry, while dendritic cells (DCs) were detected by immunofluorescence...
2017: PloS One
https://www.readbyqxmd.com/read/28255340/phenytoin-silver-a-new-nanocompound-for-promoting-dermal-wound-healing-via-comprehensive-pharmacological-action
#10
Xiao-Yu Ai, Hui-Juan Liu, Cheng Lu, Cai-Li Liang, Yan Sun, Shuang Chen, Bo Sun, Yang Li, Yan-Rong Liu, Qiang Zhang, Xue-Qiang Liu, Ting Xiao, Xue-Shuang Jing, Tao Sun, Hong-Gang Zhou, Cheng Yang
Phenytoin, an antiepileptic drug, has been widely used for wound healing. Inspired by previous studies, phenytoin silver (PnAg), a sparingly soluble silver nanocompound, was synthesized which exhibited good therapeutic efficacy in tissue repair with low toxicity (LD50 >5 g/kg). In vivo studies showed that PnAg could accelerate dermal wound healing and strong inflammation control in Sprague-Dawley rats (SD rat) and Bama minipigs. Due to its low solubility, PnAg led to low toxicity and blood enrichment in animals...
2017: Theranostics
https://www.readbyqxmd.com/read/28223520/membrane-integration-of-an-essential-%C3%AE-barrel-protein-prerequires-burial-of-an-extracellular-loop
#11
Joseph S Wzorek, James Lee, David Tomasek, Christine L Hagan, Daniel E Kahne
The Bam complex assembles β-barrel proteins into the outer membrane (OM) of Gram-negative bacteria. These proteins comprise cylindrical β-sheets with long extracellular loops and create pores to allow passage of nutrients and waste products across the membrane. Despite their functional importance, several questions remain about how these proteins are assembled into the OM after their synthesis in the cytoplasm and secretion across the inner membrane. To understand this process better, we studied the assembly of an essential β-barrel substrate for the Bam complex, BamA...
March 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28216659/the-%C3%AE-barrel-assembly-machinery-in-motion
#12
REVIEW
Nicholas Noinaj, James C Gumbart, Susan K Buchanan
In Gram-negative bacteria, the biogenesis of β-barrel outer membrane proteins (OMPs) is mediated by the β-barrel assembly machinery (BAM) complex. During the past decade, structural and functional studies have collectively contributed to advancing our understanding of the structure and function of the BAM complex; however, the exact mechanism that is involved remains elusive. In this Progress article, we discuss recent structural studies that have revealed that the accessory proteins may regulate essential unprecedented conformational changes in the core component BamA during function...
April 2017: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/28174029/effect-of-dietary-zinc-on-morphological-characteristics-and-apoptosis-related-gene-expression-in-the-small-intestine-of-bama-miniature-pigs
#13
Xin Zhou, Yansen Li, Zhaojian Li, Yun Cao, Fei Wang, ChunMei Li
To investigate the effects of dietary zinc (Zn) on small intestinal mucosal epithelium, 6-month-old male Bama miniature pigs were randomly allocated into three groups and treated with three levels of Zn (Control, T1, and T2 diet supplemented with 0, 50, and 1500mg/kg Zn, respectively, as zinc sulfate) for 38days. The samples of small intestine tissues, serum, and feces were collected. The results showed that Zn concentrations of small intestine in the T2 group were higher than those in the control and T1 groups (p<0...
February 4, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28166946/preventive-effects-of-supplemental-dietary-zinc-on-heat-induced-damage-in-the-epididymis-of-boars
#14
Zhaojian Li, Yansen Li, Xin Zhou, Yun Cao, Chunmei Li
Hyperthermia in boars reduces growth performance and sperm production. Zinc is an essential trace element in animal nutrition. Here we investigate the effects of dietary zinc on epididymal structure and function in Bama miniature pigs treated with heat exposure and investigate approaches to improve the reproductive performance in summer. Male Bama miniature pigs (n=18; aged 6 months; bodyweight=10.79±0.06kg) were randomly allocated to 3 groups: control group (Control), heat treatment group (HT), and the diet-supplemented and heat treatment group (H+Zn)...
February 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28027289/paraoxonase-1-pon1-rs662-polymorphism-and-its-association-with-serum-lipid-levels-and-longevity-in-the-bama-zhuang-population
#15
You Li, Guiyun Liang, Liwei Shi, Xue Liang, Bingshuang Long, Jian Qin, Zhiyong Zhang
BACKGROUND The present study was performed to identify the association of PON1 rs662 polymorphism with serum lipid levels and human longevity in the Bama Zhuang population. MATERIAL AND METHODS PON1 genotypes were determined by Taqman SNP Genotyping Assays in 110 long-lived inhabitants (longevity group, aged 90-110 years), 110 healthy inhabitants in Bama County (control 1 group, aged 43-82 years) and 110 healthy inhabitants in Nandan County (control 2 group, aged 28-82 years) without family history of longevity...
December 27, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27989620/flexibility-in-the-periplasmic-domain-of-bama-is-important-for-function
#16
Lisa R Warner, Petia Z Gatzeva-Topalova, Pamela A Doerner, Arthur Pardi, Marcelo C Sousa
The β-barrel assembly machine (BAM) mediates the biogenesis of outer membrane proteins (OMPs) in Gram-negative bacteria. BamA, the central BAM subunit composed of a transmembrane β-barrel domain linked to five polypeptide transport-associated (POTRA) periplasmic domains, is thought to bind nascent OMPs and undergo conformational cycling to catalyze OMP folding and insertion. One model is that conformational flexibility between POTRA domains is part of this conformational cycling. Nuclear magnetic resonance (NMR) spectroscopy was used here to study the flexibility of the POTRA domains 1-5 in solution...
January 3, 2017: Structure
https://www.readbyqxmd.com/read/27982054/mitochondrial-bacterial-hybrids-of-bama-tob55-suggest-variable-requirements-for-the-membrane-integration-of-%C3%AE-barrel-proteins
#17
Anna-Katharina Pfitzner, Nadja Steblau, Thomas Ulrich, Philipp Oberhettinger, Ingo B Autenrieth, Monika Schütz, Doron Rapaport
β-Barrel proteins are found in the outer membrane (OM) of Gram-negative bacteria, chloroplasts and mitochondria. The assembly of these proteins into the corresponding OM is facilitated by a dedicated protein complex that contains a central conserved β-barrel protein termed BamA in bacteria and Tob55/Sam50 in mitochondria. BamA and Tob55 consist of a membrane-integral C-terminal domain that forms a β-barrel pore and a soluble N-terminal portion comprised of one (in Tob55) or five (in BamA) polypeptide transport-associated (POTRA) domains...
December 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27894390/-effects-of-different-fluid-resuscitation-program-on-renal-function-in-swine-during-shock-stage-of-severe-burn
#18
G L Su, W X Huang, J Chen, D J Xue, J J Zhou
Objective: To explore the effects of different fluid resuscitation program on renal function in swine during shock stage of severe burn. Methods: Twenty-four Guangxi Bama miniature swine were inflicted with 40% total body surface area on the back, and then they were divided into four groups according to the random number table, with 6 swine in each group. At post injury hour (PIH) 2, swine in succinylated gelatin group (S), hydroxyethyl starch group (H), and allogeneic plasma group (A) were respectively resuscitated with succinylated gelatin, hydroxyethyl starch 130/0...
November 20, 2016: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/27866536/-in-vivo-and-in-vitro-experimental-studies-of-remote-digital-control-endovascular-robotic-system-in-interventional-angiography
#19
J Y Tan, L Q Jia, W H Shi, Z Y Tian, J D Tong, Y Deng, B Yu
Objective: To investigate the feasibility of the remote control endovascular robotic system in interventional angiography. Method: The endovascular robotic system Heifetz™ and the matched steerable catheter Mirage™ were used to cannulate all the target vessels in the vascular model and cerebral arteries originated from the aorta of Bama mini-pigs under fluoroscopic guidance. The technical success rate, cannulation time and exposure dose were all collected and compared with the result of using conventional techniques...
November 15, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27852910/intraosseous-injection-of-simvastatin-in-poloxamer-407-hydrogel-improves-pedicle-screw-fixation-in-ovariectomized-minipigs
#20
X Fu, J Tan, C G Sun, H J Leng, Y S Xu, C L Song
BACKGROUND: Osteoporosis leads to poor osseointegration and reduces implant stability. Statins have been found to stimulate bone formation, but the bioavailability from oral administration is low. Local application may be more effective at augmenting bone formation and enhancing implant stability. This study was performed to evaluate the efficacy of an intraosseous injection of simvastatin in thermosensitive poloxamer 407 hydrogel to enhance pedicle-screw fixation in calcium-restricted ovariectomized minipigs...
November 16, 2016: Journal of Bone and Joint Surgery. American Volume
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