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https://www.readbyqxmd.com/read/29745602/-a-study-on-the-classification-of-intestinal-contents-based-on-miniature-reflection-ultrasound
#1
Jianguo Li, Xiaoxiang Liang, Xianhui Shang, Xingbin Zheng
The present artificial anal sphincter fails to distinguish the different states of intestinal contents. In this study, we tried to distinguish the intestinal content by using a reflection type ultrasonic system, so as to lay the foundation for the development of artificial anal sphincter with sensing function. We measured the numbers of reflected waves when there were solid, liquid, gaseous or no contents in the recta of 30 Bama Miniature pigs. The results showed significant difference among the numbers of reflected waves of the 4 conditions ( F = 1 088, P < 0...
February 1, 2018: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29740124/a-targeted-boost-and-sort-immunization-strategy-using-escherichia-coli-bama-identifies-rare-growth-inhibitory-antibodies
#2
Rajesh Vij, Zhonghua Lin, Nancy Chiang, Jean-Michel Vernes, Kelly M Storek, Summer Park, Joyce Chan, Y Gloria Meng, Laetitia Comps-Agrar, Peng Luan, Sophia Lee, Kellen Schneider, Jack Bevers, Inna Zilberleyb, Christine Tam, Christopher M Koth, Min Xu, Avinash Gill, Marcy R Auerbach, Peter A Smith, Steven T Rutherford, Gerald Nakamura, Dhaya Seshasayee, Jian Payandeh, James T Koerber
Outer membrane proteins (OMPs) in Gram-negative bacteria are essential for a number of cellular functions including nutrient transport and drug efflux. Escherichia coli BamA is an essential component of the OMP β-barrel assembly machinery and a potential novel antibacterial target that has been proposed to undergo large (~15 Å) conformational changes. Here, we explored methods to isolate anti-BamA monoclonal antibodies (mAbs) that might alter the function of this OMP and ultimately lead to bacterial growth inhibition...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29736835/value-of-two-dimensional-shear-wave-elastography-for-assessing-acute-liver-congestion-in-a-bama-mini-pig-model
#3
Li-Ting Xie, Dan-Xia Xu, Guo Tian, Li-Yun Zhong, Qi-Yu Zhao, Qing-Hong Ke, Tian-An Jiang
BACKGROUND: To date, liver congestion is one of the most significant clinical diseases. However, few studies have profoundly investigated the development, pathology, and prognosis of the important problems associated with acute hepatic congestion. AIMS: To explore the value of noninvasive two-dimensional shear wave elastography (2D-SWE) for assessing acute liver congestion in an animal model. METHODS: Six healthy Bama mini-pigs were used for this research and randomly divided into the experimental group and control group...
May 8, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29606367/t-max-is-a-sensitive-indicator-of-myocardial-ischaemia-under-adenosine-stress-as-determined-by-static-pet-imaging-a-study-in-a-porcine-model
#4
S Sui, Y Hou, Y Ma, Y Wang, M Yu, Y Yang, N Huang
AIM: To evaluate Tmax , defined as the time of residual function R(t) reaching its maximum, as an indicator of myocardial ischaemia and compare its efficacy with other computed tomography perfusion (CTP) parameters. MATERIALS AND METHODS: Eight Bama miniature pigs with 50-90% left anterior descending artery stenosis underwent adenosine stress myocardial CTP and13 NNH3 position-emission tomography (PET) perfusion imaging. Tmax , myocardial blood flow (MBF), myocardial blood volume (MBV), mean transit time (MTT), and time to peak (TTP) were calculated from CTP images...
March 29, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29574509/linkage-disequilibrium-and-functional-analysis-of-pre1-insertion-together-with-snps-in-the-promoter-region-of-igfbp7-gene-in-different-pig-breeds
#5
Qingyan Wu, Hao Yu, Wenzhen Wei, Yunyun Cheng, Shan Huang, Hongyu Shi, Songcai Liu, Jichao Xia, Hongyao Jia, Linlin Hao
Polymorphisms in regions upstream of transcription initiation site may modify the transcriptional activity of target genes by changing promoter activity. This study aims to determine whether or not polymorphisms at porcine IGFBP7 promoter region affect gene expression. In this study, eight SNPs and one PRE1 insertion in this region were first confirmed. The PRE1 insertion was widespread in 20 Chinese indigenous breeds, but was not observed in three commercial breeds. A perfect linkage disequilibrium, consisting of six of those SNPs and a PRE1, was observed with two haplotypes (h1 and h2) in five pig breeds...
March 25, 2018: Journal of Applied Genetics
https://www.readbyqxmd.com/read/29559575/hitting-with-a-bam-selective-killing-by-lectin-like-bacteriocins
#6
Maarten G K Ghequire, Toon Swings, Jan Michiels, Susan K Buchanan, René De Mot
Lectin-like bacteriocins (LlpAs) are secreted by proteobacteria and selectively kill strains of their own or related species, and they are composed of two B-lectin domains with divergent sequences. In Pseudomonas spp., initial binding of these antibacterial proteins to cells is mediated by the carboxy-terminal domain through d-rhamnose residues present in the common polysaccharide antigen of their lipopolysaccharide, whereas the amino-terminal domain accounts for strain selectivity of killing. Here, we show that spontaneous LlpA-resistant mutants carry mutations in one of three surface-exposed moieties of the essential β-barrel outer membrane protein insertase BamA, the core component of the BAM complex...
March 20, 2018: MBio
https://www.readbyqxmd.com/read/29555747/monoclonal-antibody-targeting-the-%C3%AE-barrel-assembly-machine-of-escherichia-coli-is-bactericidal
#7
Kelly M Storek, Marcy R Auerbach, Handuo Shi, Natalie K Garcia, Dawei Sun, Nicholas N Nickerson, Rajesh Vij, Zhonghua Lin, Nancy Chiang, Kellen Schneider, Aaron T Wecksler, Elizabeth Skippington, Gerald Nakamura, Dhaya Seshasayee, James T Koerber, Jian Payandeh, Peter A Smith, Steven T Rutherford
The folding and insertion of integral β-barrel membrane proteins into the outer membrane of Gram-negative bacteria is required for viability and bacterial pathogenesis. Unfortunately, the lack of selective and potent modulators to dissect β-barrel folding in vivo has hampered our understanding of this fundamental biological process. Here, we characterize a monoclonal antibody that selectively inhibits an essential component of the Escherichia coli β-barrel assembly machine, BamA. In the absence of complement or other immune factors, the unmodified antibody MAB1 demonstrates bactericidal activity against an E...
March 19, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29519448/influences-of-ionic-liquid-and-temperature-on-the-tailorable-surface-morphology-of-f-apatite-nanocomposites-for-enhancing-biological-abilities-for-orthopedic-implantation
#8
Jegatheeswaran Sonamuthu, Selvam Samayanan, Anandha Raj Jeyaraman, Balaji Murugesan, Bama Krishnan, Sundrarajan Mahalingam
This report has approached for the green synthesis of morphological controlled novel metal-doped fluorinated apatite/polymeric nanocomposites. The synthesized nanocomposites have investigated for hard tissue engineering and bone substitute applications. The selected fluoro ionic liquid explored the dual performances as fluorine precursor and as a soft template for the morphological development of apatite nanocomposite synthesis. The structural and surface studies (XRD, FTIR, FE-SEM, EDS, AFM, HR-TEM & SAED) confirmed the crystalline and morphological changes of synthesized fluorohydroxyapatite nanostructures at two different reaction temperatures...
March 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29516261/therapeutic-potential-of-bama-miniature-pig-adipose-stem-cells-induced-hepatocytes-in-a-mouse-model-with-acute-liver-failure
#9
Shuang Zhang, Zhiqiang Zhu, Yufeng Wang, Shi Liu, Chenqiong Zhao, Weijun Guan, Yuhua Zhao
The role of mesenchymal stem cells (MSCs) in cellular therapy is well recognized in this work. MSCs have advantages of high proliferation, clone formation, multi-lineage differentiation and immunosuppression. Furthermore, adipose-resident MSCs (ADSCs) are extensively employed due to its advantages of abundant source, low cost and simple operation. Many researchers have emphasized the role of adipose-resident MSCs in the development of therapies for liver injury, but few attentions were paid on the use of induced functional hepatocytes...
March 7, 2018: Cytotechnology
https://www.readbyqxmd.com/read/29467854/cholecystokinin-octapeptide-inhibits-the-inflammatory-response-and-improves-neurological-outcome-in-a-porcine-model-of-cardiopulmonary-resuscitation
#10
Sen Ye, Kejia Shi, Jiefeng Xu, Moli Wang, Chun-Jian Li
Previous studies have demonstrated that cholecystokinin octapeptide (CCK8) induces hypothermia and inhibits the systemic inflammatory response in septic shock in rat and murine models. The present study aimed to ascertain whether CCK8 induced hypothermia and improved the neurological outcomes in a porcine model of cardiopulmonary resuscitation (CPR). Ventricular fibrillation was induced and left untreated for 10 min in 12 male Bama miniature pigs. Defibrillation was attempted after 5 min of CPR. At 5 min following resuscitation, the pigs were randomized and equally assigned into the CCK8 or the control group...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29463713/substrate-binding-to-bamd-triggers-a-conformational-change-in-bama-to-control-membrane-insertion
#11
James Lee, Holly A Sutterlin, Joseph S Wzorek, Michael D Mandler, Christine L Hagan, Marcin Grabowicz, David Tomasek, Mary D May, Elizabeth M Hart, Thomas J Silhavy, Daniel Kahne
The β-barrel assembly machine (Bam) complex folds and inserts integral membrane proteins into the outer membrane of Gram-negative bacteria. The two essential components of the complex, BamA and BamD, both interact with substrates, but how the two coordinate with each other during assembly is not clear. To elucidate aspects of this process we slowed the assembly of an essential β-barrel substrate of the Bam complex, LptD, by changing a conserved residue near the C terminus. This defective substrate is recruited to the Bam complex via BamD but is unable to integrate into the membrane efficiently...
March 6, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29431737/a-dna-nanorobot-functions-as-a-cancer-therapeutic-in-response-to-a-molecular-trigger-in-vivo
#12
Suping Li, Qiao Jiang, Shaoli Liu, Yinlong Zhang, Yanhua Tian, Chen Song, Jing Wang, Yiguo Zou, Gregory J Anderson, Jing-Yan Han, Yung Chang, Yan Liu, Chen Zhang, Liang Chen, Guangbiao Zhou, Guangjun Nie, Hao Yan, Baoquan Ding, Yuliang Zhao
Nanoscale robots have potential as intelligent drug delivery systems that respond to molecular triggers. Using DNA origami we constructed an autonomous DNA robot programmed to transport payloads and present them specifically in tumors. Our nanorobot is functionalized on the outside with a DNA aptamer that binds nucleolin, a protein specifically expressed on tumor-associated endothelial cells, and the blood coagulation protease thrombin within its inner cavity. The nucleolin-targeting aptamer serves both as a targeting domain and as a molecular trigger for the mechanical opening of the DNA nanorobot...
March 2018: Nature Biotechnology
https://www.readbyqxmd.com/read/29399062/the-effect-of-hydroxy-safflower-yellow-a-on-coronary-heart-disease-through-bcl-2-bax-and-ppar-%C3%AE
#13
Dayan Zhou, Zongjie Qu, Hao Wang, Yong Su, Yazhu Wang, Weiwei Zhang, Zhe Wang, Qiang Xu
The aim of the present study was to investigate the effect of hydroxy safflower yellow A (HSYA) on coronary heart disease through assessing the expression of B-cell lymphoma 2 (Bcl-2)/Bcl-2-like protein 4 (Bax) and peroxisome proliferator-activated receptor (PPAR)-γ. Coronary heart disease was induced in male Bama miniature swines via thoracoscope to serve as an animal model. Coronary heart disease swine were lavaged with 20 or 40 mg/kg HSYA. The mRNA levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-10, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) were detected using reverse transcription-quantitative polymerase chain reaction...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29368762/effects-of-structures-of-bidentate-schiff-base-type-bonded-ligands-derived-from-benzaldehyde-on-the-photoluminescence-performance-of-polymer-rare-earth-complexes
#14
Baojiao Gao, Liqin Zhang, Dandan Zhang
Two kinds of bidentate Schiff base ligands derived from benzaldehyde, benzaldehyde/m-aminophenol (BAMA) type and benzaldehyde/glutamic acid (BAGL) type ligands, were synchronously synthesized and bonded on the backbone of polysulfone (PSF) through molecular design and by polymer reactions, and two functional polymers, PSF-BAMA and PSF-BAGL, were obtained. Then two series of novel luminescent Schiff base-type polymer-rare earth complexes were prepared via coordination reactions. In this work, the effects of the structures of the bonded ligands on the photoluminescence performance of the complexes were investigated in detail, and for the different photophysical properties of the prepared complexes, relevant theoretical explanations were given...
January 25, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29324294/microbial-community-of-a-gasworks-aquifer-and-identification-of-nitrate-reducing-azoarcus-and-georgfuchsia-as-key-players-in-btex-degradation
#15
Martin Sperfeld, Charlotte Rauschenbach, Gabriele Diekert, Sandra Studenik
We analyzed a coal tar polluted aquifer of a former gasworks site in Thuringia (Germany) for the presence and function of aromatic compound-degrading bacteria (ACDB) by 16S rRNA Illumina sequencing, bamA clone library sequencing and cultivation attempts. The relative abundance of ACDB was highest close to the source of contamination. Up to 44% of total 16S rRNA sequences were affiliated to ACDB including genera such as Azoarcus, Georgfuchsia, Rhodoferax, Sulfuritalea (all Betaproteobacteria) and Pelotomaculum (Firmicutes)...
April 1, 2018: Water Research
https://www.readbyqxmd.com/read/29229778/structural-and-functional-insights-into-the-role-of-bamd-and-bame-within-the-%C3%AE-barrel-assembly-machinery-in-neisseria-gonorrhoeae
#16
Aleksandra E Sikora, Igor H Wierzbicki, Ryszard A Zielke, Rachael F Ryner, Konstantin V Korotkov, Susan K Buchanan, Nicholas Noinaj
The β-barrel assembly machinery (BAM) is a conserved multicomponent protein complex responsible for the biogenesis of β-barrel outer membrane proteins (OMPs) in Gram-negative bacteria. Given its role in the production of OMPs for survival and pathogenesis, BAM represents an attractive target for the development of therapeutic interventions, including drugs and vaccines against multidrug-resistant bacteria such as Neisseria gonorrhoeae The first structure of BamA, the central component of BAM, was from N. gonorrhoeae , the etiological agent of the sexually transmitted disease gonorrhea...
January 26, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29220705/therapeutic-landscapes-and-longevity-wellness-tourism-in-bama
#17
Liyuan Huang, Honggang Xu
Due to the rising demand for healthcare products and concern over environmental pollution, wellness tourism has been booming in China in recent years. The therapeutic landscape theory provides a multi-scale interpretation of wellness tourism to explore how wellness tourists achieve health in healing places. By presenting the results of 83 interviews conducted in Bama, China, this study reveals that the "longevity village" Bama, endorsed by centenarians, provides a retreat that combines natural beauty and a harmonious neighbourhood for wellness tourists...
January 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29212841/benefits-of-hyperbaric-oxygen-pretreatment-for-decompression-sickness-in-bama-pigs
#18
Long Qing, Hong-Jie Yi, Ye-Wei Wang, Quan Zhou, Dinesh K Ariyadewa, Wei-Gang Xu
Decompression sickness (DCS) occurs when ambient pressure is severely reduced during diving and aviation. Hyperbaric oxygen (HBO) pretreatment has been shown to exert beneficial effects on DCS in rats via heat-shock proteins (HSPs). We hypothesized that HBO pretreatment will also reduce DCS via HSPs in swine models. In the first part of our investigation, six swine were subjected to a session of HBO treatment. HSP32, 60, 70 and 90 were detected, before and at 6, 12, 18, 24 and 30 h following exposure in lymphocytes...
March 7, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29202315/effect-of-enrofloxacin-and-roxarsone-on-cyp450s-in-pig
#19
Yinsheng Li, Meilin Jiang, Michelle Thunders, Xiaojie Ai, Jiangping Qiu
Enrofloxacin (ENR) and roxarsone (ROX) have been widely used in animal breeding. In this study, the daily clinical dosage of ENR and daily additive amount of ROX were administrated to Bama pigs. After 5days, the activity and protein expression of three important enzymes in the cytochrome P450 family were measured in the porcine liver. CYP1A2 was induced by both ENR and ROX independently. CYP2E1 and CYP3A4 were inhibited by ENR, but not affected by ROX. The combined administration of ENR and ROX were antagonistic to CYP1A2 and CYP2E1, but not to CYP3A4...
November 21, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29197585/studying-assembly-of-the-bam-complex-in-native-membranes-by-cellular-solid-state-nmr-spectroscopy
#20
Cecilia Pinto, Deni Mance, Manon Julien, Mark Daniels, Markus Weingarth, Marc Baldus
Significant progress has been made in obtaining structural insight into the assembly of the β-barrel assembly machinery complex (BAM). These crystallography and electron microscopy studies used detergent as a membrane mimetic and revealed structural variations in the central domain, BamA, as well as in the lipoprotein BamC. We have used cellular solid-state NMR spectroscopy to examine the entire BamABCDE complex in native outer membranes and obtained data on the BamCDE subcomplex in outer membranes, in addition to synthetic bilayers...
November 29, 2017: Journal of Structural Biology
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