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https://www.readbyqxmd.com/read/29355720/zileuton-alleviates-acute-cisplatin-nephrotoxicity-inhibition-of-lipoxygenase-pathway-favorably-modulates-the-renal-oxidative-inflammatory-caspase-3-axis
#1
Mai M Helmy, Amel A Hashim, Samar M Mouneir
OBJECTIVE: The current study investigated for the first time the possible beneficial effect of zileuton, a selective 5-lipoxygenase inhibitor (5-LOX), against cisplatin-induced acute renal failure. METHODOLOGY: Male Sprague-Dawley rats (180-200 g) were administered cisplatin once (5 mg/kg, i.p.) alone or combined with oral zileuton (10 mg/kg, given twice; 1 hour before and 12 hours after cisplatin). RESULTS: Compared with control rats, acute cisplatin administration caused significant increases of BUN (33...
January 17, 2018: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/29355653/discovery-and-validation-of-serum-creatinine-variability-as-novel-biomarker-for-predicting-onset-of-albuminuria-in-type-2-diabetes-mellitus
#2
Serena Low, Xiao Zhang, Keven Ang, Su Jian Darren Yeo, Guanyi Joel Lim, Lee Ying Yeoh, Yan Lun Liu, Tavintharan Subramaniam, Chee Fang Sum, Su Chi Lim
AIM: We aim to study association serum creatinine(cr) variability and albuminuria progression. METHODS: We conducted a retrospective cohort study on patients with Type 2 Diabetes Mellitus at a Diabetes Centre in Singapore ("discovery cohort"). Outcome is worsening of urinary albumin-to-creatinine(ACR) across stages. Cr variability was expressed as adjusted cr-intrapersonal standard deviation(SD) and coefficient-of-variation(cr-CV). A separate cohort was used for validating association between cr variability and albuminuria progression ("validation cohort")...
January 17, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29355652/liraglutide-ameliorates-early-renal-injury-by-the-activation-of-renal-foxo1-in-a-type-2-diabetic-kidney-disease-rat-model
#3
Pin Chen, Xiaozhi Shi, Xiangjin Xu, Yiyang Lin, Zhulin Shao, Rongdan Wu, Lihong Huang
AIMS: The aim of this study was to investigate the effects of liraglutide on renal injury and the renal expression of FoxO1 in type 2 diabetic rats. METHODS: Type 2 diabetic rats model was induced by a high-sugar and high-fat diet and intraperitoneal injection of low-dose Streptozotocin (STZ)(30 mg/kg). Five weeks after STZ injection, diabetic rats were randomly treated with or without subcutaneous injection of liraglutide (0.2 mg/kg/12 h) for eight weeks. Diabetes-related physical and biochemical indicators, renal histopathological and ultrastructural changes, the expression of renal transforming growth factor beta-1 (TGF-β1), fibronectin (FN), type IV collagen (Col IV), protein kinase B (Akt), forkhead box protein O1 (FoxO1) and manganese superoxide dismutase (MnSOD) were measured...
January 17, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29355545/the-urinary-excretion-of-metformin-ceftizoxime-and-ofloxacin-in-high-serum-creatinine-rats-can-creatinine-predict-renal-tubular-elimination
#4
Yan-Rong Ma, Yan Zhou, Jing Huang, Hong-Yan Qin, Pei Wang, Xin-An Wu
The renal excretion of creatinine and most drugs are the net result of glomerular filtration and tubular secretion, and their tubular secretions are mediated by individual transporters. Thus, we hypothesized that the increase of serum creatinine (SCr) levels attributing to inhibiting tubular transporters but not glomerular filtration rate (GFR) could be used to evaluate the tubular excretion of drugs mediated by identical or partial overlap transporter with creatinine. In this work, we firstly developed the creatinine excretion inhibition model with normal GFR by competitively inhibiting tubular transporters, and investigated the renal excretion of metformin, ceftizoxime and ofloxacin in vivo and in vitro...
January 17, 2018: Life Sciences
https://www.readbyqxmd.com/read/29355173/paradigms-of-acute-kidney-injury-in-the-intensive-care-setting
#5
REVIEW
John A Kellum, John R Prowle
Acute kidney injury (AKI) is a heterogeneous clinical syndrome that has multiple aetiologies, variable pathogenesis and diverse outcomes. However, these heterogeneities are not reflected in current approaches to the diagnosis and, to some degree, treatment of AKI. For example, congestive heart failure and dehydration can produce identical changes in serum creatinine level and urine output (parameters that are used to define AKI); however, they differ vastly in their physiological contexts and demand completely opposite treatments...
January 22, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29355160/predictive-factors-of-management-outcome-in-adult-patients-with-mechanical-intestinal-obstruction
#6
Adebambo Olalekan Bankole, Adedapo Olumide Osinowo, Adedoyin Adekunle Adesanya
BACKGROUND: Mechanical intestinal obstruction (MIO) is a common and potentially fatal surgical emergency, which constitutes about 20% of all admissions to the surgical emergency departments. OBJECTIVE: To determine the predictive factors of morbidity and mortality in patients undergoing treatment for MIO at our tertiary hospital. PATIENTS AND METHODS: This was a prospective study of consecutive patients, 18 years and above, that presented with features of MIO during a 1-year period (May 2014 to April 2015)...
October 2017: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29355065/effect-of-combination-of-vitamin-e-and-umbilical-cord-derived-mesenchymal-stem-cells-on-inflammation-in-mice-with-acute-kidney-injury
#7
Qiongqiong Guo, Junxia Wang
BACKGROUND: The objective of this study is to investigate the effect of combination of umbilical cord-derived mesenchymal stem cell (UC-MSC) and vitamin E (VitE) on inflammation in mice with acute kidney injury (AKI). METHODS: UC-MSCs were isolated from pregnant wistar mice and cultured. A total of 90 female wistar mice were randomly divided into control group, AKI group, AKI + VitE group, AKI + UC-MSC group, and AKI + VitE + UC-MSC group (18 mice in each group) which were given no treatment, normal saline, VitE, UC-MSC, and VitE + UC-MSC, respectively...
January 22, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29354930/-skin-needle-embedding-for-obese-impaired-glucose-tolerance
#8
Jinghua Liang, Zhendi Feng, Shengkui Feng, Shude Bao, Kejia Wang
OBJECTIVE: To explore the effect difference between the skin needle embedding therapy and western medication for obese impaired glucose tolerance (IGT). METHODS: A total of 300 cases of obese IGT were assigned into an embedding group and a western medication group by random number table, 150 cases in each one. Standardized diagnosis and treatment programs were applied to reduce blood pressure, lipid, weight, and exercise and scientific diet management were used...
January 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29354873/clinical-characteristics-associated-with-subcutaneous-tophi-formation-in-chinese-gout-patients-a-retrospective-study
#9
Lidan Ma, Ruixia Sun, Zhaotong Jia, Yaowu Zou, Ying Xin, Xiaoyu Cheng, Tian Liu, Lingling Cui, Zhen Liu, Xinjiang Wu, Changgui Li
The objective of this study is to analyze clinical characteristics associated with the formation of subcutaneous tophi among Chinese gout patients. It was a retrospective outpatient cohort study. Five thousand six hundred ninety-three gout patients treated at the Affiliated Hospital of Qingdao University from March 2011 to February 2016 were included and divided into the tophus group and non-tophus group according to the presence of megascopic tophus. Relevant clinical information and biochemical parameters were analyzed to identify potential risk factors for the incidence of subcutaneous tophi...
January 22, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29353826/the-association-between-glomerular-filtration-rate-estimated-on-admission-and-acute-stroke-outcome-the-shiga-stroke-registry
#10
Aryandhito Widhi Nugroho, Hisatomi Arima, Itsuko Miyazawa, Takako Fujii, Naomi Miyamatsu, Yoshihisa Sugimoto, Satoru Nagata, Masaru Komori, Naoyuki Takashima, Yoshikuni Kita, Katsuyuki Miura, Kazuhiko Nozaki
AIM: Although renal dysfunction has been identified as a novel risk factor affecting stroke prognosis, few have analyzed the association within large-scale population-based setting, using wide-range estimated glomerular filtration rate (eGFR) category. We aimed to determine the association of admission eGFR with acute stroke outcomes using data from a registry established in Shiga Prefecture, Japan. METHODS: Following exclusion of patients younger than 18 years, with missing serum creatinine data, and with onset more than 7 days prior to admission, 2,813 acute stroke patients registered in the Shiga Stroke Registry year 2011 were included in the final analysis...
January 19, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29353381/effect-of-kaempferol-pretreatment-on-myocardial-injury-in-rats
#11
Anamika Vishwakarma, Thakur Uttam Singh, Soya Rungsung, Tarun Kumar, Arunvikram Kandasamy, Subhashree Parida, Madhu Cholenahalli Lingaraju, Ajay Kumar, Asok Kumar, Dinesh Kumar
The present study was undertaken to evaluate the effect of kaempferol in isoprenaline (ISP)-induced myocardial injury in rats. ISP was administered subcutaneously for two subsequent days to induce myocardial injury. Assessment of myocardial injury was done by estimation of hemodynamic functions, myocardial infarcted area, cardiac injury markers, lipid profile, oxidative stress, pro-inflammatory cytokines and histopathology of heart and liver. Rats pretreated with kaempferol showed reduction in the myocardial infarcted area and heart rate...
January 20, 2018: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/29353328/serum-uric-acid-levels-are-associated-with-lupus-nephritis-in-patients-with-normal-renal-function
#12
Ana Luisa Calich, Eduardo Ferreira Borba, Michelle Remião Ugolini-Lopes, Luiza Fuoco da Rocha, Eloisa Bonfá, Ricardo Fuller
Uric acid has been recognised as a potential marker of endothelial dysfunction and kidney disease but there are scarce data about its importance in systemic lupus erythematosus (SLE) nephritis. This study aimed to evaluate serum uric acid (UA) levels in lupus nephritis (LN), by comparing SLE patients with normal renal function, with and without nephritis. Forty-six female SLE patients were consecutively selected and divided in two groups according to renal activity at the evaluation: presence of a recently diagnosed lupus nephritis (LN+, n = 18) and absence of lupus nephritis (LN-, n = 28)...
January 20, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29353206/dihydroartemisinin-ameliorates-sepsis-induced-hyperpermeability-of-glomerular-endothelium-via-up-regulation-of-occludin-expression
#13
Zuowang Cheng, Ruixia Qi, Liqun Li, Qiang Liu, Wenqian Zhang, Xia Zhou, Dongmei Xu, Thaddeus D Allen, Silin Pan, Ju Liu
Sepsis, the systemic inflammatory responses after infection, remains a serious cause of morbidity and mortality in critically ill patients. The anti-malarial agent dihydroartemisinin (DHA) has been shown to be anti-inflammatory. In this study, we examined the effects of DHA on sepsis-induced acute kidney injury (AKI) and explored the mechanism underlying its mode of action in AKI. In a lipopolysaccharide (LPS)-induced mouse model, we observed that DHA treatment ameliorated glomerular injury, and relieved elevation of the urine albumin to creatinine ratio (UACR) and serum creatinine...
January 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29352693/the-association-between-estimated-glomerular-filtration-rate-albuminuria-and-risk-of-cardiovascular-hospitalizations-and-all-cause-mortality-among-patients-with-type-2-diabetes
#14
Gregory A Nichols, Anouk Déruaz-Luyet, Sibylle J Hauske, Kimberly G Brodovicz
AIMS: We evaluated the simultaneous effects of all clinically recognized categories of albuminuria and estimated glomerular filtration rate (eGFR) on cardiovascular disease (CVD) and mortality. METHODS: We conducted a longitudinal observational study of 16,678 type 2 diabetes (T2D) patients. From the first serum creatinine value from 2006 to 2012 and a urine-albumin creatinine ratio (UACR) recorded within 6months, we applied baseline Kidney Disease: Improving Global Outcomes (KDIGO) categories of eGFR and albuminuria...
December 18, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29352692/ckd-epi-versus-cockcroft-gault-formula-for-predicting-contrast-induced-nephropathy-following-percutaneous-coronary-intervention-in-patients-without-significant-renal-impairment
#15
Mário B G Nunes, Antônio C Filho, Valéria R C Alvares, Rafael Moreno, Edgar Lamas, Vitor Loures, Daniel Chamié, Alexandre Abizaid
INTRODUCTION: Individuals with glomerular filtration rate (GFR) ≥60 ml/min/1.73 m2 estimated by the Cockcroft-Gault formula (CG) who undergo percutaneous coronary intervention (PCI) frequently develop contrast-induced nephropathy (CIN). This study aimed to assess whether individuals with significant renal impairment assessed by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula, but not by CG, more often develop CIN following PCI than those without renal impairment by either formula...
January 15, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29351386/protective-effect-of-c-peptide-on-experimentally-induced-diabetic-nephropathy-and-the-possible-link-between-c-peptide-and-nitric-oxide
#16
Eman A Elbassuoni, Neven M Aziz, Nashwa F El-Tahawy
Diabetic nephropathy one of the major microvascular diabetic complications. Besides hyperglycemia, other factors contribute to the development of diabetic complications as the proinsulin connecting peptide, C-peptide. We described the role of C-peptide replacement therapy on experimentally induced diabetic nephropathy, and its potential mechanisms of action by studying the role of Nitric oxide (NO) as a mediator of C-peptide effects by in vivo modulating its production by NG-nitro-L-arginine methyl ester (L-NAME)...
January 19, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29351251/compatibility-with-panax-notoginseng-and-rehmannia-glutinosa-alleviates-the-hepatotoxicity-and-nephrotoxicity-of-tripterygium-wilfordii-via-modulating-the-pharmacokinetics-of-triptolide
#17
Qichun Zhang, Yiqun Li, Mengzhu Liu, Jinao Duan, Xueping Zhou, Huaxu Zhu
Tripterygium wilfordii (TW) and the representative active component triptolide show positive therapeutic effect on the autoimmune disorders and simultaneously ineluctable hepatotoxicity and nephrotoxicity. Combinational application of Panax notoginseng (PN) and Rehmannia glutinosa (RG) weakens the toxicity of TW according the clinical application of traditional Chinese medicine. This article was aimed at the mechanism of decreasing toxicity of TW by the combinational application of PN and RG. Biochemical and pathohistological analysis were utilized to assess the toxicity on liver and kidney in rats administrated with TW, TW-PN, TW-RG and TW-PN-RG for 3 and 7 days...
January 19, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29350174/automated-peritoneal-dialysis-could-rapidly-improve-left-heart-failure-by-increasing-peritoneal-dialysis-ultrafiltration-a-single-center-observational-clinical-study%C3%A2
#18
Cong Yang, Jixing Liu, Nirong Gong, Yanhong Lin, Yanfang He, Zhixiu Yi, Liping Hu, Jianping Jiang, Jun Ai
Ultrafiltration failure (UFF) is a major cause of water retention, left heart failure (LHF), and peritoneal dialysis (PD) failure. Automated peritoneal dialysis (APD) might have better ultrafiltration (UF) than continuous ambulatory peritoneal dialysis (CAPD). Here, we have studied whether short-term APD could increase UF and improve LHF. 47 patients were included in this study from December 1, 2015, to January 1, 2017. All patients had been treated with CAPD before they came to our center and were treated with APD in the hospital...
January 19, 2018: Clinical Nephrology
https://www.readbyqxmd.com/read/29349920/hyperuricemia-in-asian-psoriatic-arthritis-patients
#19
Tin Lok Lai, Cheuk Wan Yim, Pui Yan Wong, Man Chi Leung, Woon Leung Ng
AIM: It is generally accepted that hyperuricemia is commonly associated with psoriatic arthritis (PsA). However, variations in ethnicity, diet and habitat may contribute to differences in prevalence and risk factors for hyperuricemia in PsA patients. Moreover, Asian specific data is deficient. The primary objective of the present study was to determine the prevalence of hyperuricemia among PsA patients. The secondary objective was to explore its associated risk factors. METHODS: This was a multi-center, cross-sectional observational study of 160 PsA patients from local Rheumatology clinics...
January 18, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29349642/increased-serum-periostin-concentrations-are-associated-with-the-presence-of-diabetic-retinopathy-in-patients-with-type-2-diabetes-mellitus
#20
Y Ding, Q Ge, H Qu, Z Feng, J Long, Q Wei, Q Zhou, R Wu, L Yao, H Deng
PURPOSE: To determine the association between serum periostin and the presence of diabetic retinopathy (DR). METHODS: Serum periostin was detected in 114 healthy subjects, 122 patients with type 2 diabetes mellitus (T2DM) and 159 patients with DR and compared among groups. Clinical data and other laboratory measurements such as glycated hemoglobin (HbA1c), lipid profiles, serum creatinine (Cr) and high-sensitivity CRP (hsCRP) were also collected and compared among groups...
January 18, 2018: Journal of Endocrinological Investigation
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