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https://www.readbyqxmd.com/read/29793166/renoprotective-effect-of-the-isoflavonoid-biochanin-a-against-cisplatin-induced-acute-kidney-injury-in-mice-effect-on-inflammatory-burden-and-p53-apoptosis
#1
Faiha A Suliman, Dina M Khodeer, Afaf Ibrahiem, Eman T Mehanna, Mohamed K El-Kherbetawy, Hala M F Mohammad, Sawsan A Zaitone, Yasser M Moustafa
Cisplatin is a potent widely-used chemotherapeutics; however, its clinical use is associated with nephrotoxicity. Renoprotective approaches are being discovered to halt the tubular cell death due to inflammatory and apoptotic burdens. In the present study, the renoprotective effects of different doses of biochanin A (10, 20 or 40 mg/kg) in mice treated with a single injection of cisplatin (10 mg/kg) were reported. Cisplatin administration resulted in marked increases in serum creatinine and blood urea nitrogen...
May 21, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29792163/different-patterns-of-inflammatory-and-angiogenic-factors-are-associated-with-peritoneal-small-solute-transport-and-peritoneal-protein-clearance-in-peritoneal-dialysis-patients
#2
Yuanyuan Shi, Hao Yan, Jiangzi Yuan, He Zhang, Jiaying Huang, Zhaohui Ni, Jiaqi Qian, Wei Fang
BACKGROUND: Both peritoneal small solute transport and peritoneal protein clearance are closely linked to outcomes in peritoneal dialysis (PD) patients. However, the associated factors of these two components are not fully understood so far. This study aimed to investigate the association between a panel of systemic and peritoneal inflammatory and angiogenic factors and peritoneal solute transport properties. METHODS: Stable PD patients in PD center of Renji Hospital, School of Medicine, Shanghai Jiao Tong University were enrolled in present study...
May 23, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29791495/early-prediction-of-contrast-induced-acute-kidney-injury-by-a-bedside-assessment-of-neutrophil-gelatinase-associated-lipocalin-during-elective-percutaneous-coronary-interventions
#3
Annunziata Nusca, Marco Miglionico, Claudio Proscia, Laura Ragni, Massimiliano Carassiti, Francesca Lassandro Pepe, Germano Di Sciascio
Contrast-induced acute kidney injury (CI-AKI) is a serious complication during percutaneous coronary interventions (PCI). Currently, the diagnosis of CI-AKI relies on serum creatinine (SCr) that is however affected by several limitations potentially leading to delayed or missed diagnoses. In this study we examined the diagnostic accuracy of a "bedside" measurement of plasma Neutrophil Gelatinase-Associated Lipocalin (NGAL) in the early detection of CI-AKI in 97 patients undergoing elective PCI. The overall incidence of CI-AKI was 3%...
2018: PloS One
https://www.readbyqxmd.com/read/29790392/interleukin-1-receptor-il-1r1-activation-exacerbates-toxin-induced-acute-kidney-injury
#4
Jamie R Privratsky, Jiandong Zhang, Xiaohan Lu, Nathan Rudemiller, Qingqing Wei, Yen-Rei Yu, Michael Dee Gunn, Steven D Crowley
Acute kidney injury (AKI) is a leading cause of morbidity and mortality. Cisplatin is an effective chemotherapeutic agent whose administration is limited by nephrotoxicity. Therapies to prevent cisplatin-induced AKI are lacking. While tumor necrosis factor-α (TNF) plays a key role in the pathogenesis of cisplatin nephrotoxicity, the immune signaling pathways that trigger TNF generation in this context require elucidation. Sterile injury triggers the release and activation of both isoforms of interleukin(IL)-1, IL-1α and IL-1β, and stimulation of the interleukin-1 receptor (IL-1R1) by these ligands engages a pro-inflammatory signaling cascade that induces TNF induction...
May 23, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29790115/n-2-hydroxyphenyl-acetamide-and-its-gold-nanoparticle-conjugation-prevent-glycerol-induced-acute-kidney-injury-by-attenuating-inflammation-and-oxidative-injury-in-mice
#5
Rehan Ahmed Siddiqui, Shabana Usman Simjee, Nurul Kabir, Muhammad Ateeq, M Raza Shah, Syed Saad Hussain
The protective activity of N-(2-hydroxyphenyl)acetamide (NA-2) and NA-2-coated gold nanoparticles (NA-2-AuNPs) in glycerol-treated model of acute kidney injury (AKI) in mice was investigated. NA-2 (50 mg/kg) and NA-2-AuNPs (30 mg/kg) were given to the animals for four days followed by 24-h water deprivation and injection of 50% glycerol (10 ml/kg im). The animals were sacrificed on the next day. Blood and kidneys were collected for biochemical investigations (urea and creatinine), histological studies (hematoxylin and eosin; and periodic acid-Schiff staining), immunohistochemistry (actin and cyclooxygenase-2, Cox-2), and real-time RT-PCR (inducible nitric oxide synthase, iNOS; nuclear factor-κB p50, NFκB; hemeoxygenase-1, HO-1; and kidney injury molecule-1, Kim-1)...
May 22, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29790109/value-of-three-dimensional-speckle-tracking-echocardiography-to-assess-left-ventricular-function-in-hyperuricemia-patients
#6
Xiaojie Zhang, Qing Lu, Zhuojun Zhang, Yongle Chen, Yanan Wang, Youngshi Wang, Zheng Li, Lindi Jiang
To assess the value of three-dimensional speckle tracking echocardiography (3D STE) in evaluating the left ventricular (LV) function in hyperuricemia patients. We enrolled 15 healthy controls and 40 hyperuricemia patients and collected and analyzed full-volume 3D STE images of the left ventricle in the apical four-chamber heart view. Laboratory tests and 3D STE parameters, including left ventricular ejection fraction, left ventricular end-diastolic volume, left ventricular end-systolic volume, stroke volume (SV), global longitudinal strain (GLS), and global circumferential strain (GCS), were compared between hyperuricemia patients and healthy controls...
May 22, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29790081/transplant-renal-vein-thrombosis-in-a-recipient-with-aberrant-venous-anatomy
#7
Lyndsey Thiessen, Sarah MacDonell, Chris Wall, Preman Jacob, Ahmed Shoker, Michael A J Moser
Renal vein thrombosis in a transplanted kidney is an uncommon but critical complication that can result in graft loss if management is delayed. A 31-year-old male with known atresia of the inferior vena cava who received a deceased donor renal transplant 7 years previously presented to hospital with severe graft site pain and a week of nausea, vomiting, and chills. Serum creatinine was markedly elevated from baseline. Sonographic examination revealed external iliac vein thrombosis with extension of the thrombus into the transplant renal vein...
May 22, 2018: CEN Case Reports
https://www.readbyqxmd.com/read/29789925/associations-of-polymorphisms-of-cyp2d6-and-cyp2c9-with-early-onset-severe-pre-eclampsia-and-response-to-labetalol-therapy
#8
Cheng-Juan Sun, Lin Li, Xue-Yan Li, Wei-Yuan Zhang, Xiao-Wei Liu
PURPOSE: Early onset preeclampsia (PPE) contributes to life-threatening maternal complications and fetal demise. Pharmacogenomics is a precision medicine, and metabolizing enzymes responsive to antihypertensive remains understudied. The aim of this study was to evaluate the associations of polymorphisms of cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6) and cytochrome P450, family 2, subfamily C, polypeptide 9 (CYP2C9) with PPE and the relationship among CYP2D6, CYP2C9 polymorphisms and response to labetalol therapy...
May 22, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29789212/fibrates-in-primary-prevention-of-cardiovascular-disease-comments-on-the-results-of-a-systematic-review-of-the-cochrane-collaboration
#9
Angel Brea, Jesús Millán, Juan F Ascaso, Mariano Blasco, Angel Díaz, Antonio Hernández-Mijares, Teresa Mantilla, Juan C Pedro-Botet, Xavier Pintó
Fibrates are drugs that reduce triglycerides, elevate high-density lipoproteins, as well as decrease small, dense LDL particles. The results of a study have recently been published by the Cochrane Collaboration on fibrates efficacy and safety in the primary prevention of cardiovascular disease. This study includes a systematic review and a meta-analysis of 6 studies (16,135 patients) that evaluated the clinical benefits of fibrates compared to placebo use or other lipid-lowering drugs. This review showed evidence of a protective effect of the fibrates compared with placebo as regards a reduction 16% of a compound objective of death due to cardiovascular disease, non-fatal myocardial infarction, or non-fatal cerebrovascular accident (NNT: 112), and that reduce coronary morbidity and mortality by 21% (NNT: 125)...
May 19, 2018: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/29788896/association-between-delayed-graft-function-dgf-biomarkers-and-long-term-outcomes-after-living-donor-kidney-transplantation
#10
Zahra Sahraei, Mona Mehdizadeh, Jamshid Salamzadeh, Mohsen Nafar, Azadeh Eshraghi
BACKGROUND AND OBJECTIVES: The Association between preoperative Urine Neutrophil Gelatinase-associated Lipocalin (uNGAL) and interlukin-18 (uIL-18) with poor 1-year allograft function has been shown in deceased-donor kidney transplant recipients previously, and also these markers could predict 3-month allograft function. However, it is unknown whether there is any association between these postoperative biomarkers with important recipient outcomes beyond this time in live-donor transplants...
May 21, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29788810/clinical-and-immunological-pattern-and-outcome-of-egyptian-systemic-lupus-erythematosus-patients-a-single-center-experience
#11
G A Mahmoud, A A Shahin, H S Zayed, A Moghazy, B M Eissa
Objective The objective of this study was to describe the clinical and immunological pattern and disease outcome in Egyptian systemic lupus erythematosus patients. Patients and methods The medical records of 770 systemic lupus erythematosus patients who were followed from 2002-2015 at Kasr Alainy Hospital, Cairo University, were retrospectively reviewed. Results There were 707 (91.8%) females. The mean age at disease onset was 22.1 ± 8.6 and the disease duration was 6.1 ± 4.5 years. The main clinical manifestations were mucocutaneous (90...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29788462/clinicopathological-predictors-for-progression-of-chronic-kidney-disease-in-nephrosclerosis-a-biopsy-based-cohort-study
#12
Masayuki Yamanouchi, Junichi Hoshino, Yoshifumi Ubara, Kenmei Takaichi, Keiichi Kinowaki, Takeshi Fujii, Kenichi Ohashi, Koki Mise, Tadashi Toyama, Akinori Hara, Miho Shimizu, Kengo Furuichi, Takashi Wada
Background: Biopsy-based studies on nephrosclerosis are lacking and the clinicopathological predictors for progression of chronic kidney disease (CKD) are not well established. Methods: We retrospectively assessed 401 patients with biopsy-proven nephrosclerosis in Japan. Progression of CKD was defined as new-onset end-stage renal disease, decrease of estimated glomerular filtration rate (eGFR) by  ≥50% or doubling of serum creatinine, and the sub-distribution hazard ratio (SHR) with 95% confidence interval (CI) for CKD progression was determined for various clinical and histological characteristics in competing risks analysis...
May 19, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29787368/contemporary-surgical-outcomes-of-venous-tumour-thrombectomy-managed-with-intraoperative-doppler-ultrasound-for-kidney-cancer
#13
Deepak K Pruthi, Hanzhang Wang, Arpan Satsangi, Miguel Cajipe, Kevan Iffrig, Georges M Haidar, Taylor Hicks, Edward Y Sako, Michael A Liss, Wasim H Chowdhury, Ronald Rodriguez, Dharam Kaushik
INTRODUCTION: Radical nephrectomy (RN) with venous tumour thrombectomy (VTT) carries a significant morbidity and mortality risk. Examination of a contemporary single-institution series permits the development of a management algorithm and an audit its results. We report outcomes following the use of intraoperative colour Doppler ultrasound and our surgical pathway. METHODS: We retrospectively reviewed the records of all patients who underwent RN with VTT for kidney cancer between January 1, 2013 and October 1, 2016...
May 14, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29786454/serum-cystatin-c-as-an-early-predictor-of-acute-kidney-injury-in-preterm-neonates-with-respiratory-distress-syndrome
#14
Tarek Mohey El-Gammacy, Dina Mohamed Shinkar, Noha Refaat Mohamed, Amany Rasmy Al-Halag
Preterm neonates with respiratory distress syndrome (RDS) are at increased risk of acute kidney injury (AKI). Our study aimed at determining whether serum cystatin C (sCysC) on day 3 of life (D3) can early predict AKI in preterm neonates with RDS. This prospective study was conducted on 75 preterm neonates; 50 with RDS and 25 without RDS. On D3, sCysC, serum creatinine (sCr) and blood urea nitrogen (BUN) were measured and estimated glomerular filtration rate (eGFR) was calculated. sCr and BUN levels were measured again on days 5 and 7...
May 22, 2018: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29785573/effect-of-dietary-soy-oil-glucose-and-glutamine-on-growth-performance-amino-acid-profile-blood-profile-immunity-and-antioxidant-capacity-in-weaned-piglets
#15
Dinghong Lv, Xia Xiong, Huansheng Yang, Meiwei Wang, Yijie He, Yanhong Liu, Yulong Yin
Weaning stress results in gastrointestinal dysfunction and depressed performance in pigs. This study aimed to investigate the effect of soy oil, glucose, and glutamine on the growth and health of weaned piglets. Compared with those in the glutamine group, piglets in the glucose and soy oil groups had greater average daily gain, average daily feed intake, and gain: feed ratio from day 0 to 14, and gain: feed ratio for the overall period. There were no differences with regard to serum amino acids among the three groups on day 14, except glycine and threonine...
May 18, 2018: Science China. Life Sciences
https://www.readbyqxmd.com/read/29785539/the-effect-of-spironolactone-on-the-incidence-of-contrast-induced-nephropathy-in-patients-undergoing-cardiac-catheterization-study-design-and-rationale
#16
Alhasan Mujtaba, Mohammed A Taher, Mazin A Hazza, Hassan M Al-Rubaye, Asaad H Kata, Hamid AbdulWahab, AbdulAmeer AbdulBari, Hayder K AlRubay
INTRODUCTION: Patients undergoing coronary catheterization are at high risk of developing contrast-induced nephropathy (CIN) acute kidney injury (AKI). Several approaches have been supposed to limit such an effect but with mixed results or non-practical methods. Spironolactone is supposed to be effective as a nephroprotective agent in animal studies. This study will try to measure the effect of spironolactone on the incidence of CIN-AKI in patients undergoing coronary catheterization (angiography angioplasty)...
May 21, 2018: Cardiology and Therapy
https://www.readbyqxmd.com/read/29785131/epidemiology-susceptibility-and-risk-factors-for-acquisition-of-mdr-xdr-gram-negative-bacteria-among-kidney-transplant-recipients-with-urinary-tract-infections
#17
Xiuhong Yuan, Taohua Liu, Di Wu, Qiquan Wan
Background: Multiple drug resistant/extensively drug resistant (MDR/XDR) Gram-negative urinary tract infections (UTIs) represent a growing threat to kidney transplant recipients. This retrospective study aimed to assess the incidence and microbiological profile of MDR/XDR Gram-negative UTIs, to identify drug susceptibility of MDR/XDR bacteria, and to determine the potential risk factors for MDR/XDR UTIs in kidney recipients. Materials and methods: During the study period, 1569 patients underwent consecutive kidney transplantation in two transplantation centers...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29784554/renal-stress-and-kidney-injury-biomarkers-in-response-to-endurance-cycling-in-the-heat-with-and-without-ibuprofen
#18
Brendon P McDermott, Cody R Smith, Cory L Butts, Aaron R Caldwell, Elaine C Lee, Jakob L Vingren, Colleen X Munoz, Laura J Kunces, Keith Williamson, Matthew S Ganio, Lawrence E Armstrong
Exercise, especially in the heat, can contribute to acute kidney injury, which can expedite chronic kidney disease onset. The additional stress of ibuprofen use is hypothesized to increase renal stress. OBJECTIVES: To observe the effects of endurance cycling in the heat on renal function. Secondarily, we investigated the effect of ibuprofen ingestion on kidney stress. DESIGN: Randomized, placebo controlled and observational methods were utilized. METHODS: Forty cyclists (52±9y, 21...
May 16, 2018: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29783931/short-term-sequelae-of-preeclampsia-a-single-center-cohort-study
#19
Michael Girsberger, Catherine Muff, Irene Hösli, Michael Jan Dickenmann
BACKGROUND: Data on the prevalence of persistent symptoms in the first year after preeclampsia are limited. Furthermore, possible risk factors for these sequelae are poorly defined. We investigated kidney function, blood pressure, proteinuria and urine sediment in women with preeclampsia 6 months after delivery with secondary analysis for possible associated clinical characteristics. METHODS: From January 2007 to July 2014 all women with preeclampsia and 6-months follow up at the University Hospital Basel were analyzed...
May 21, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29783819/-value-of-urine-soluble-triggering-receptor-expressed-on-myeloid-cells-1-in-the-early-diagnosis-of-sepsis-associated-acute-kidney-injury
#20
Z K Yuan, F Fang, C J Liu, J Li, Y F Chen, F Xu
Objective: To assess the value of urine soluble triggering receptor expressed on myeloid cells-1(sTREM-1) in early diagnosis and prognosis of sepsis associated acute kidney injury (AKI). Methods: This was a case-control study. A total of 62 patients with sepsis during November 2016 to June 2017 were collected, who were divided into non-AKI sepsis ( n= 49) and AKI sepsis ( n= 13) groups according to the serum creatinine (SCr) or urine output, sepsis with shock ( n= 22) and sepsis without shock ( n= 40) groups according to the presence of shock, survival ( n= 47) and death ( n= 15) groups according to the mortality...
May 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
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