Marta Mellai, Laura Annovazzi, Renzo Boldorini, Luca Bertero, Paola Cassoni, Pasquale De Blasio, Ida Biunno, Davide Schiffer
Suppressor of Lin-12-like (C. elegans) (SEL1L) participates in the endoplasmic reticulum-associated protein degradation pathway, malignant transformation and stem cell biology. We explored the role of SEL1L in 110 adult gliomas, of different molecular subtype and grade, in relation to cell proliferation, stemness, glioma-associated microglia/macrophages (GAMs), prognostic markers and clinical outcome. SEL1L protein expression was assessed by immunohistochemistry and Western blotting. Genetic and epigenetic alterations were detected by molecular genetics techniques...
May 20, 2019: Journal of Pathology. Clinical Research