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https://www.readbyqxmd.com/read/27889995/the-roles-of-the-unique-prolyl-isomerase-pin1-in-cancer-related-viral-and-bacterial-infections
#1
J Wang, X-H Liao, M Zheng, D Yang, X Z Zhou, H Liu, K P Lu
Infection is the process of pathogen invasion, as well as the host reaction to the foreign agents. Proline-directed phosphorylation is a major regulatory mechanism that regulates the function of fundamental proteins involved in infection and infection-induced cancer. Recently, the identification of the phosphorylation-dependent prolyl isomerase Pin1 has uncovered a unique regulatory signaling mechanism controlling protein conformation and function after phosphorylation. Pin1 is the only proline isomerase that specifically recognizes certain Pro-directed Ser/Thr phosphorylation motifs...
November 23, 2016: Current Molecular Medicine
https://www.readbyqxmd.com/read/27878998/the-transition-from-somatic-to-germline-identity-shows-conserved-and-specialized-features-during-angiosperm-evolution
#2
Jorge Lora, María Herrero, Matthew R Tucker, José I Hormaza
How and why specific plant cells adopt germline identity during ovule development has proved challenging to address, and the pathways that are active in the ovules of basal/early-divergent angiosperms possessing a multilayered nucellus are still unclear. Here, we compare megasporogenesis between two early-divergent angiosperms (Annona cherimola and Persea americana) and the evolutionarily derived Arabidopsis thaliana, studying the three-dimensional spatial position of the megaspore mother cell (MMC), the compositional details of the MMC wall and the location of PIN1 expression...
November 23, 2016: New Phytologist
https://www.readbyqxmd.com/read/27876426/pin1-and-secondary-hyperparathyroidism-of-chronic-kidney-disease-gene-polymorphisms-and-protein-levels
#3
Yu Zhao, Li-Li Zhang, Fa-Xian Ding, Ping Cao, Yuan-Yuan Qi, Jing Wang
BACKGROUND: Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (Pin1) is a key regulator of PTH mRNA stability. Secondary hyperparathyroidism (SHPT), which is characterized by elevated serum PTH levels, is a common complication of CKD. We investigated the possible associations between CKD with SHPT (CKD SHPT) and single-nucleotide polymorphisms of the Pin1 gene and compared the levels of the Pin1 protein in the CKD SHPT patients with those of the controls. METHODS: The study group included 251 CKD SHPT patients and 61 controls...
November 23, 2016: Renal Failure
https://www.readbyqxmd.com/read/27863418/pin1-induces-the-adp-induced-migration-of-human-dental-pulp-cells-through-p2y1-stabilization
#4
Soo-A Kim, Hong Seok Choi, Sang-Gun Ahn
PIN1, which belongs to a family of prolyl isomerases, specifically binds to phosphorylated Ser/Thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. This study aimed to investigate the importance of Pin1 expression in human dental pulp cells (hDPCs) to understand the involvement of Pin1 in the regulation of P2Y1 and the activation of ADP-mediated P2Y1 signaling. This study found that the protein levels of P2Y1 gradually decreased after the onset of cell recovery following heat stress...
November 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27846390/erk-activation-globally-downregulates-mirnas-through-phosphorylating-exportin-5
#5
Hui-Lung Sun, Ri Cui, JianKang Zhou, Kun-Yu Teng, Yung-Hsuan Hsiao, Kotaro Nakanishi, Matteo Fassan, Zhenghua Luo, Guqin Shi, Esmerina Tili, Huban Kutay, Francesca Lovat, Caterina Vicentini, Han-Li Huang, Shih-Wei Wang, Taewan Kim, Nicola Zanesi, Young-Jun Jeon, Tae Jin Lee, Jih-Hwa Guh, Mien-Chie Hung, Kalpana Ghoshal, Che-Ming Teng, Yong Peng, Carlo M Croce
MicroRNAs (miRNA) are mostly downregulated in cancer. However, the mechanism underlying this phenomenon and the precise consequence in tumorigenesis remain obscure. Here we show that ERK suppresses pre-miRNA export from the nucleus through phosphorylation of exportin-5 (XPO5) at T345/S416/S497. After phosphorylation by ERK, conformation of XPO5 is altered by prolyl isomerase Pin1, resulting in reduction of pre-miRNA loading. In liver cancer, the ERK-mediated XPO5 suppression reduces miR-122, increases microtubule dynamics, and results in tumor development and drug resistance...
November 14, 2016: Cancer Cell
https://www.readbyqxmd.com/read/27836548/functional-characterisation-of-parvulin-type-peptidyl-prolyl-cis-trans-isomerase-pina-in-dictyostelium-discoideum
#6
Nemneineng Haokip, Aruna Naorem
Pin1-type parvulins are unique among PPIases that can catalyse an otherwise slow cis-trans isomerisation of phosphorylated peptide bond preceding proline in target proteins. This prolyl isomerisation process can regulate activity, stability and localisation of target proteins and thus control cellular processes like eukaryotic cell proliferation, cell cycle progression and gene regulation. Towards understanding the function of Pin1-type prolyl isomerisation in Dictyostelium discoideum, a slime mould with distinct growth and developmental phases, we identified PinA as a novel Pin1-type parvulin by its ability to complement the temperature sensitivity phenotype associated with a mutation in ESS1 in S...
November 9, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27834957/pin1-in-breast-development-and-cancer-a-clinical-perspective
#7
REVIEW
Alessandra Rustighi, Alessandro Zannini, Elena Campaner, Yari Ciani, Silvano Piazza, Giannino Del Sal
Mammary gland development, various stages of mammary tumorigenesis and breast cancer progression have the peptidyl-prolyl cis/trans isomerase PIN1 at their centerpiece, in virtue of the ability of this unique enzyme to fine-tune the dynamic crosstalk between multiple molecular pathways. PIN1 exerts its action by inducing conformational and functional changes on key cellular proteins, following proline-directed phosphorylation. Through this post-phosphorylation signal transduction mechanism, PIN1 controls the extent and direction of the cellular response to a variety of inputs, in physiology and disease...
November 11, 2016: Cell Death and Differentiation
https://www.readbyqxmd.com/read/27818174/auxin-acts-through-monopteros-to-regulate-plant-cell-polarity-and-pattern-phyllotaxis
#8
Neha Bhatia, Behruz Bozorg, André Larsson, Carolyn Ohno, Henrik Jönsson, Marcus G Heisler
The periodic formation of plant organs such as leaves and flowers gives rise to intricate patterns that have fascinated biologists and mathematicians alike for hundreds of years [1]. The plant hormone auxin plays a central role in establishing these patterns by promoting organ formation at sites where it accumulates due to its polar, cell-to-cell transport [2-6]. Although experimental evidence as well as modeling suggest that feedback from auxin to its transport direction may help specify phyllotactic patterns [7-12], the nature of this feedback remains unclear [13]...
December 5, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/27800612/direct-delivery-of-recombinant-pin1-protein-rescued-osteoblast-differentiation-of-pin1-deficient-cells
#9
Woo-Jin Kim, Rabia Islam, Bong-Soo Kim, Young-Dan Cho, Won-Joon Yoon, Jeong-Hwa Baek, Kyung-Mi Woo, Hyun-Mo Ryoo
Pin1 is a peptidyl prolyl cis-trans isomerase that specifically binds to the phosphoserine-proline or phosphothreonine-proline motifs of several proteins. We reported that Pin1 plays a critical role in the fate determination of Smad1/5, Runx2 and β-catenin that are indispensable nuclear proteins for osteoblast differentiation. Though several chemical inhibitors has been discovered for Pin1, no activator has been reported as of yet. In this study, we directly introduced recombinant Pin1 protein successfully into the cytoplasm via fibroin nanoparticle encapsulated in cationic lipid...
November 1, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27793831/strigolactone-regulates-shoot-development-through-a-core-signalling-pathway
#10
Tom Bennett, Yueyang Liang, Madeleine Seale, Sally Ward, Dörte Müller, Ottoline Leyser
Strigolactones are a recently identified class of hormone that regulate multiple aspects of plant development. The DWARF14 (D14) α/β fold protein has been identified as a strigolactone receptor, which can act through the SCF(MAX2) ubiquitin ligase, but the universality of this mechanism is not clear. Multiple proteins have been suggested as targets for strigolactone signalling, including both direct proteolytic targets of SCF(MAX2), and downstream targets. However, the relevance and importance of these proteins to strigolactone signalling in many cases has not been fully established...
November 8, 2016: Biology Open
https://www.readbyqxmd.com/read/27790836/neighboring-phosphoser-pro-motifs-in-the-undefined-domain-of-irak1-impart-bivalent-advantage-for-pin1-binding
#11
Monique J Rogals, Alexander I Greenwood, Jeahoo Kwon, Kun Ping Lu, Linda K Nicholson
The peptidyl prolyl isomerase Pin1 has two domains that are considered to be its binding (WW) and catalytic (PPIase) domains, both of which interact with phosphorylated Ser/Thr-Pro motifs. This shared specificity might influence substrate selection, as many known Pin1 substrates have multiple sequentially close phosphoSer/Thr-Pro motifs, including the protein interleukin-1 receptor-associated kinase-1 (IRAK1). The IRAK1 undefined domain (UD) contains two sets of such neighboring motifs (Ser131/Ser144 and Ser163/Ser173), suggesting possible bivalent interactions with Pin1...
October 28, 2016: FEBS Journal
https://www.readbyqxmd.com/read/27772826/the-role-of-pin1-in-hepatocellular-carinoma-is-associated-with-tp53-status
#12
Jun Sang Bae, Sik Lee, Kyu Yun Jang, Woo Sung Moon
No abstract text is available yet for this article.
February 2016: Pathology
https://www.readbyqxmd.com/read/27770268/sensitizing-effect-of-juglone-is-mediated-by-down-regulation-of-notch1-signaling-pathway-in-trastuzumab-resistant-skbr3-cells
#13
Soraya Sajadimajd, Razieh Yazdanparast
Trastuzumab (Herceptin) monoclonal antibody directed against HER2 receptor has been administered as a treatment for metastatic HER2 positive breast cancer. The problematic issue in treatment of HER2 positive breast cancer cells is commonly the induction of resistance to trastuzumab which might be due to modulation of some vital signaling elements such as Notch1 and Pin1. In this study, we were aimed to investigate whether the cross talk between pin1 and Notch1 has a role in this event. Our results indicated that the expression level of Pin1 in resistant SKBR3 cells increased by about twofold relative to sensitive SKBR3 cells...
October 21, 2016: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/27757735/amsacrine-induced-apoptosis-of-human-leukemia-u937-cells-is-mediated-by-the-inhibition-of-akt-and-erk-induced-stabilization-of-mcl1
#14
Yuan-Chin Lee, Ying-Jung Chen, Chia-Hui Huang, Long-Sen Chang
Previous studies have attributed the anticancer activity of amsacrine to its inhibitory effect on topoisomerase II. However, 9-aminoacridine derivatives, which have the same structural scaffold as amsacrine, induce cancer cell apoptosis by altering the expression of BCL2 family proteins. Therefore, in the present study, we assessed whether BCL2 family proteins mediated the cytotoxic effects of amsacrine on human leukemia U937 cells. Amsacrine-induced apoptosis of U937 cells was characterized by caspase-9 and caspase-3 activation, increased intracellular Ca(2+) concentration, mitochondrial depolarization, and MCL1 down-regulation...
October 19, 2016: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/27737904/cytokinin-response-factors-integrate-auxin-and-cytokinin-pathways-for-female-reproductive-organ-development
#15
Mara Cucinotta, Silvia Manrique, Andrea Guazzotti, Nadia E Quadrelli, Marta A Mendes, Eva Benkova, Lucia Colombo
The developmental programme of the pistil is under the control of both auxin and cytokinin. Crosstalk between these factors converges on regulation of the auxin carrier PIN-FORMED 1 (PIN1). Here, we show that in the triple transcription factor mutant cytokinin response factor 2 (crf2) crf3 crf6 both pistil length and ovule number were reduced. PIN1 expression was also lower in the triple mutant and the phenotypes could not be rescued by exogenous cytokinin application. pin1 complementation studies using genomic PIN1 constructs showed that the pistil phenotypes were only rescued when the PCRE1 domain, to which CRFs bind, was present...
December 1, 2016: Development
https://www.readbyqxmd.com/read/27733863/the-m3-phosphorylation-site-is-required-for-trafficking-and-biological-roles-of-pin-formed1-2-and-7-in-arabidopsis
#16
Daeeun Ki, Daisuke Sasayama, Hyung-Taeg Cho
Asymmetrically localized PIN-FORMED (PIN) auxin efflux carriers play key roles in regulating directional intercellular auxin movement, generating local auxin gradients, and diverse auxin-mediated growth and development. The polar localization of PINs is controlled by phosphorylation in the central hydrophilic loop (HL) of PINs. Although the M3 phosphorylation site, including phosphorylatable 5 Ser/Thr residues, is conserved among long HL-PINs, its native role has only been characterized in PIN3. In this study, we examined the role of M3 phosphorylation site of PIN1, PIN2, and PIN7 in intracellular trafficking, phosphorylation, and biological functions of those PINs in their native expressing tissues...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27720394/g-protein-coupled-receptor-kinase-2-grk2-promotes-breast-tumorigenesis-through-a-hdac6-pin1-axis
#17
Laura Nogués, Clara Reglero, Verónica Rivas, Alicia Salcedo, Vanesa Lafarga, Maria Neves, Paula Ramos, Marta Mendiola, Alberto Berjón, Kostas Stamatakis, Xiao Zhen Zhou, Kun Ping Lu, David Hardisson, Federico Mayor, Petronila Penela
In addition to oncogenic drivers, signaling nodes can critically modulate cancer-related cellular networks to strength tumor hallmarks. We identify G-protein-coupled receptor kinase 2 (GRK2) as a relevant player in breast cancer. GRK2 is up-regulated in breast cancer cell lines, in spontaneous tumors in mice, and in a proportion of invasive ductal carcinoma patients. Increased GRK2 functionality promotes the phosphorylation and activation of the Histone Deacetylase 6 (HDAC6) leading to de-acetylation of the Prolyl Isomerase Pin1, a central modulator of tumor progression, thereby enhancing its stability and functional interaction with key mitotic regulators...
October 1, 2016: EBioMedicine
https://www.readbyqxmd.com/read/27697905/boronic-acid-treatment-phenocopies-monopteros-by-affecting-pin1-membrane-stability-and-polar-auxin-transport-in-arabidopsis-thaliana-embryos
#18
Michaela Matthes, Ramón A Torres-Ruiz
Several observations suggest that the micronutrient boron (B) has a stabilising role in the plasma membrane (PM), supporting functions in PM-linked (hormone) signalling processes. However, this role is poorly characterised. Here we show treatment with boronic acids, specific competitors of B, phenocopies the Arabidopsis thaliana rootless pattern mutant monopteros. At least in part, this is caused by phenylboronic acid (PBA)-induced internalisation of the membrane-localised auxin efflux carrier PINFORMED1 (PIN1) in the early embryo...
November 1, 2016: Development
https://www.readbyqxmd.com/read/27692510/synthesis-and-pin1-inhibitory-activity-of-thiazole-derivatives
#19
Hailong Zhao, Guonan Cui, Jing Jin, Xiaoguang Chen, Bailing Xu
Pin1 (Protein interacting with NIMA1) is a peptidyl prolyl cis-trans isomerase (PPIase) which specifically catalyze the conformational conversion of the amide bond of pSer/Thr-Pro motifs in its substrate proteins and is a novel promising anticancer target. A series of new thiazole derivatives were designed and synthesized, and their inhibitory activities were measured against human Pin1 using a protease-coupled enzyme assay. Of all the tested compounds, a number of thiazole derivatives bearing an oxalic acid group at 4-position were found to be potent Pin1 inhibitors with IC50 values at low micromolar level...
September 21, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27649687/vascular-cambium-regeneration-and-vessel-formation-in-wounded-inflorescence-stems-of-arabidopsis
#20
Ewa Mazur, Eva Benková, Jiří Friml
Synchronized tissue polarization during regeneration or de novo vascular tissue formation is a plant-specific example of intercellular communication and coordinated development. According to the canalization hypothesis, the plant hormone auxin serves as polarizing signal that mediates directional channel formation underlying the spatio-temporal vasculature patterning. A necessary part of canalization is a positive feedback between auxin signaling and polarity of the intercellular auxin flow. The cellular and molecular mechanisms of this process are still poorly understood, not the least, because of a lack of a suitable model system...
2016: Scientific Reports
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