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https://www.readbyqxmd.com/read/28810587/association-of-polycystic-ovary-syndrome-with-metabolic-syndrome-and-gestational-diabetes-aggravated-complication-of-pregnancy
#1
Kui Yao, Ce Bian, Xia Zhao
Polycystic ovary syndrome (PCOS) affects 5-20% of the reproductive age women globally. PCOS is diagnosed by the presence of hyperandrogenism, oligo-anovulation, and polycystic morphology of at least one ovary. Insulin resistance (IR), hyperinsulinemia and associated metabolic abnormalities including metabolic syndrome play a significant role in the development of PCOS. The chances of developing MS in PCOS women was shown to increase by almost 14-fold in patients with increasing body mass index. Even in the absence of overt obesity, a preferential deposition of intra-abdominal fat is noted in PCOS women and this intra-abdominal fat leads to impaired insulin action and functional IR and hyperandrogenism...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28807396/polycystic-ovary-morphology-age-based-ultrasound-criteria
#2
Hyun-Jun Kim, Judith M Adams, Jens A Gudmundsson, Gudmundur Arason, Cindy T Pau, Corrine K Welt
OBJECTIVE: To determine age-based criteria for polycystic ovary morphology. DESIGN: Cross-sectional, case-control design. SETTING: Outpatient setting. SUBJECT(S): Women with polycystic ovary syndrome (PCOS) defined by hyperandrogenism and irregular menses (n = 544) and controls with regular menses and no evidence of hyperandrogenism (n = 666) participated. Parameters were tested in a second cohort of women with PCOS (n = 105) and controls (n = 32) meeting the same criteria...
August 11, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28803524/endocrinopathies-in-paediatric-onset-neuromyelitis-optica-spectrum-disorder-with-aquaporin-4-aqp4-antibody
#3
Yael Hacohen, Silvia Messina, Hoong-Wei Gan, Sukhvir Wright, Saleel Chandratre, Maria Isabel Leite, Penny Fallon, Angela Vincent, Olga Ciccarelli, Evangeline Wassmer, Ming Lim, Jacqueline Palace, Cheryl Hemingway
The involvement of the diencephalic regions in neuromyelitis optica spectrum disorder (NMOSD) may lead to endocrinopathies. In this study, we identified the following endocrinopathies in 60% (15/25) of young people with paediatric-onset aquaporin 4-Antibody (AQP4-Ab) NMOSD: morbid obesity ( n = 8), hyperinsulinaemia ( n = 5), hyperandrogenism ( n = 5), amenorrhoea ( n = 5), hyponatraemia ( n = 4), short stature ( n = 3) and central hypothyroidism ( n = 2) irrespective of hypothalamic lesions...
August 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28794543/synchronizing-pharmacotherapy-in-acne-with-review-of-clinical-care
#4
REVIEW
Sarvajnamurthy Aradhya Sacchidanand, Koushik Lahiri, Kiran Godse, Narendra Gajanan Patwardhan, Anil Ganjoo, Rajendra Kharkar, Varsha Narayanan, Dhammraj Borade, Lyndon D'souza
Acne is a chronic inflammatory skin disease that involves the pathogenesis of four major factors, such as androgen-induced increased sebum secretion, altered keratinization, colonization of Propionibacterium acnes, and inflammation. Several acne mono-treatment and combination treatment regimens are available and prescribed in the Indian market, ranging from retinoids, benzoyl peroxide (BPO), anti-infectives, and other miscellaneous agents. Although standard guidelines and recommendations overview the management of mild, moderate, and severe acne, relevance and positioning of each category of pharmacotherapy available in Indian market are still unexplained...
July 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28791858/the-pathogenesis-and-treatment-of-polycystic-ovary-syndrome-what-s-new
#5
REVIEW
Sylwia Bednarska, Agnieszka Siejka
Polycystic ovary syndrome (PCOS) is currently the leading cause of menstrual complications in women. It is characterized by clinical and/or biochemical hyperandrogenism, ovulation abnormalities and the presence of enlarged and/or polycystic ovaries in ultrasound images (12 or more small bubbles located circumferentially and/or ovarian volume > 10 mL). It is often comorbid with hyperinsulinemia, dyslipidemia, overweight or obesity, and is a risk factor for the development of diabetes and cardiovascular diseases (CVDs)...
March 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28791833/history-of-discovery-of-polycystic-ovary-syndrome
#6
REVIEW
(no author information available yet)
Stein and Leventhal are regarded to have been the first investigators of polycystic ovary syndrome (PCOS); however, in 1721 Vallisneri, an Italian scientist, described a married, infertile woman with shiny ovaries with a white surface, and the size of pigeon eggs. It was not until the early 1990s at a National Institute of Health (NIH) sponsored conference on PCOS that formal diagnostic criteria were proposed and afterwards largely utilized. Many scientists tried to explain the pathophysiology of PCOS and many studies were made...
May 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28758509/polycystic-ovary-syndrome-among-obese-adolescents
#7
Marina Ybarra, Ruth Rocha Franco, Louise Cominato, Raissa Beltrão Sampaio, Silvia Maria Sucena da Rocha, Durval Damiani
BACKGROUND AND AIMS: In adolescence and obesity, the pathophysiology of polycystic ovary syndrome (PCOS) is very difficult to distinguish. We aimed to assess the diagnosis of PCOS in the population of obese adolescent. METHODS: Cross-sectional study. SETTING: Pediatric Endocrinology Weight and Management Clinic from Children's Institute, São Paulo, Brazil. PARTICIPANTS: Forty-nine post-menarcheal obese adolescents with mean age of 14...
July 29, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28742467/polycystic-ovary-syndrome-in-adolescents-which-mr-imaging-based-diagnostic-criteria
#8
Maxime Fondin, Antoine Rachas, Van Huynh, Stéphanie Franchi-Abella, Jean-Paul Teglas, Lise Duranteau, Catherine Adamsbaum
Purpose To evaluate the validity and reproducibility of magnetic resonance (MR) imaging-based ovarian morphologic measurements for diagnosis of polycystic ovary syndrome (PCOS) in adolescents. Materials and Methods This case-control study included 110 adolescent girls (age range, 13-17 years) who underwent pelvic MR imaging in 2006-2015. The case group included girls with high (n = 40, hyperandrogenism and oligomenorrhea or amenorrhea), intermediate (n = 8, hyperandrogenism), or low (n = 7, oligomenorrhea or amenorrhea) suspicion of PCOS...
July 25, 2017: Radiology
https://www.readbyqxmd.com/read/28735644/fasting-as-possible-complementary-approach-for-polycystic-ovary-syndrome-hope-or-hype
#9
Benito Chiofalo, Antonio Simone Laganà, Vittorio Palmara, Roberta Granese, Giacomo Corrado, Emanuela Mancini, Salvatore Giovanni Vitale, Helena Ban Frangež, Eda Vrtačnik-Bokal, Onofrio Triolo
Polycystic ovary syndrome (PCOS) is a common endocrine system disorder among women of reproductive age. In several cases, PCOS women show infertility or subfertility and other metabolic alteration, such as insulin resistance (InsR), dyslipidaemia, hyperinsulinemia and obesity. Despite the aetiology of the syndrome is still far from be elucidated, it could be considered the result of concurrent endocrine modifications, lifestyle factors and genetic background. In particular, accumulating evidence suggests that InsR and compensatory hyperinsulinemia play a pivotal pathogenic role in the hyperandrogenism of many PCOS phenotypes, which in turn have a clear detrimental effect on chronic anovulation...
August 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28733169/implications-of-the-2014-androgen-excess-and-polycystic-ovary-syndrome-society-guidelines-on-polycystic-ovarian-morphology-for-polycystic-ovary-syndrome-diagnosis
#10
J P Christ, M N Gunning, B C J M Fauser
The Androgen Excess and Polycystic Ovary Syndrome Society (AEPCOS) has recommended an updated threshold for polycystic ovarian morphology (PCOM) of 25 follicles or more, 10 ml or more of ovarian volume, or both. We describe the effect of these guidelines on reproductive and metabolic characteristics in 404 women. These women were separated into four groups: group A: hyperandrogenism and oligo-amenorrhoea (n = 157); group B: hyperandrogenism or oligo-amenorrhoea and PCOM meeting AEPCOS 2014 criteria (n = 125); group C: hyperandrogenism or oligo-amenorrhoea and PCOM meeting Rotterdam 2003 but not AEPCOS 2014 criteria (n = 72); and group D: non-PCOS not meeting either criteria (n = 50)...
July 8, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28727126/the-incidence-of-metabolic-syndrome-in-adolescents-with-different-phenotypes-of-pcos
#11
Kubra Zengin Altintas, Berna Dilbaz, Derya Akdag Cirik, Runa Ozelci, Tuba Zengin, Osman Nuri Erginay, Serdar Dilbaz
OBJECTIVES: To evaluate the incidence of metabolic syndrome in Turkish adolescents with different phenotypes of polycystic ovary syndrome (PCOS). MATERIAL AND METHODS: This cross-sectional study was performed on the Youth Center clinic of a tertiary referral hospital in Turkey. Adolescents with PCOS (n = 144) were classified into four phenotype groups according to the presence of oligo/anovulation (O), hyperandrogenism (H), and polycystic ovarian morphology (P) as follows: Phenotype A (O + H + P), Phenotype B (H + O), Phenotype C (H + P), Phenotype D (O + P)...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28724177/natural-molecules-for-the-therapy-of-hyperandrogenism-and-metabolic-disorders-in-pcos
#12
V Cappelli, M C Musacchio, A Bulfoni, G Morgante, V De Leo
OBJECTIVE: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy of women of reproductive age and a complex endocrine condition, due to its heterogeneity and uncertainty about its etiology. However, PCOS is also associated with other metabolic abnormalities such as insulin resistance, impaired glucose tolerance, and diabetes. There are few medications that are approved for the most common symptoms of PCOS, leading to the off-label use of medications that were approved for other indications...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28715060/the-complex-interaction-between-polycystic-ovary-syndrome-and-hereditary-angioedema-case-reports-and-review-of-the-literature
#13
Marina Iahn-Aun, Marcelo Vivolo Aun, Antonio Abílio Motta, Jorge Kalil, Pedro Giavina-Bianchi, Sylvia Asaka Hayashida, Edmund Chada Baracat, Gustavo Arantes Maciel
Importance: Hereditary angioedema (HAE) is a rare but severe disease, with high risk of death, and attacks have been associated to high estrogen levels. Polycystic ovary syndrome (PCOS) is a common hyperandrogenic condition, which is frequently treated with combined oral contraceptives. Objective: The aim of this study was to describe 2 clinical cases of young women diagnosed as having PCOS who developed HAE attacks after the introduction of combined estrogen-progestin pills to treat PCOS symptoms...
July 2017: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/28711608/do-anabolic-androgenic-steroids-have-performance-enhancing-effects-in-female-athletes
#14
REVIEW
Grace Huang, Shehzad Basaria
Doping with anabolic-androgenic steroids (AAS) is common among both male and female athletes and is a growing public health problem. Review of historical data of systematic state-sponsored doping programs implemented by the German Democratic Republic in elite female athletes and from clinical trials of testosterone administration in non-athlete women suggests that AAS have ergogenic effects in women. The use of AAS in female athletes has been associated with adverse effects that include acne, hirsutism, deepening of the voice and menstrual disturbances; life-threatening adverse effects such as cardiac arrhythmias and sudden death have also been reported...
July 12, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28693619/successful-pregnancy-after-mucinous-cystic-neoplasm-with-invasive-carcinoma-of-the-pancreas-in-a-patient-with-polycystic-ovarian-syndrome-a-case-report
#15
Conisha Holloman, S J Carlan, Lohini Sundharkrishnan, Angela Guzman, Mario Madruga
BACKGROUND: The incidence of invasive cancer within a mucinous cystic neoplasm of the pancreas varies between 6 and 36%. Polycystic ovarian syndrome is a disorder characterized by hyperandrogenism and anovulatory infertility. One surgical treatment that can restore endocrine balance and ovulation in polycystic ovarian syndrome is partial ovarian destruction. Successful pregnancies following preconception pancreaticoduodenectomies (Whipple procedures) and chemoradiation to treat pancreatic neoplasms have been reported rarely but none were diagnosed with pre-cancer polycystic ovarian syndrome-associated infertility...
July 11, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28685911/combined-lifestyle-and-herbal-medicine-in-overweight-women-with-polycystic-ovary-syndrome-pcos-a-randomized-controlled-trial
#16
Susan Arentz, Caroline A Smith, Jason Abbott, Paul Fahey, Birinder S Cheema, Alan Bensoussan
Polycystic ovary syndrome (PCOS) is a common, complex reproductive endocrinopathy characterized by menstrual irregularities, hyperandrogenism and polycystic ovaries. Lifestyle modification is a first-line intervention; however, there are barriers to success for this form of self-care, and women often seek adjunct therapies including herbal medicines. This pragmatic, randomized controlled trial, delivered in communities of Australia in overweight women with PCOS, compared the effectiveness and safety of a lifestyle intervention plus herbal medicine against lifestyle alone...
July 7, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28679622/extra-ovarian-gonadotropin-negative-feedback-revealed-by-aromatase-inhibition-in-female-marmoset-monkeys
#17
Marissa Kraynak, Matthew T Flowers, Robert A Shapiro, Amita Kapoor, Jon Levine, David H Abbott
While the ovary produces the majority of estradiol (E2) in mature female primates, extra-ovarian sources contribute to E2 synthesis and action, including brain E2 regulating hypothalamic gonadotropin-releasing hormone (GnRH). In ovary-intact female rodent models, aromatase inhibition (AI) induces a PCOS-like hypergonadotropic hyperandrogenism due to absent E2-mediated negative feedback. In order to examine the role of extra-ovarian E2 on nonhuman primate gonadotropin regulation, the present study employs letrozole to elicit AI in adult female marmoset monkeys...
July 5, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28669219/the-prevalence-of-non-classic-congenital-adrenal-hyperplasia-due-to-21-hydroxylase-deficiency-in-russian-women-with-hyperandrogenism
#18
Elena Grodnitskaya, Mark Kurtser
The aim of the study was to determine the prevalence of non-classic congenital adrenal hyperplasia (NCAH) due to 21-hydroxylase (21-OH) deficiency among hyperandrogenic women in a Russian population and to evaluate diagnostic value of basal serum 17-hydroxyprogesterone (17-OHP) level to diagnose this disease. A total of 800 consecutive Caucasian women presenting with elevation of at least one serum androgen and/or manifestation of one of the clinical androgenic symptoms were prospectively recruited and evaluated by basal 17-OHP...
July 3, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28657375/metabolic-effect-of-obesity-on-polycystic-ovary-syndrome-in-adolescents-a-meta-analysis
#19
Li Li, Qiong Feng, Ming Ye, Yaojuan He, Aling Yao, Kun Shi
This meta-analysis provides an updated and comprehensive estimate of the effects of obesity on metabolic disorders in adolescent polycystic ovary syndrome (PCOS). Relevant articles consistent with the search terms published up to 31 January 2014 were retrieved from PubMed, EMBASE, PsycINFO and CENTRAL. Thirteen articles (16 independent studies) conformed to the inclusion criteria. The evaluated outcomes were the metabolic parameters of obese adolescents with PCOS (case group) relative to normal-weight adolescents with PCOS, or obese adolescents without PCOS...
June 28, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28649885/can-the-source-of-hyperandrogenism-in-adolescents-with-polycystic-ovary-syndrome-predict-metabolic-phenotype
#20
Alaa Al Nofal, Lyndsay D Viers, Asma Javed
In this study, we demonstrated an association between adrenal hyperandrogenism, as determined by dehydroepiandrostenedione-to-free testosterone (DHEA-S/FT) ratio, and metabolic phenotype in obese and lean adolescents with polycystic ovary syndrome (PCOS). We compared 64 overweight/obese adolescents with PCOS (PCOS-O) with 18 lean (PCOS-L) adolescents. We analyzed the association between DHEA-S/FT ratios and metabolic parameters. Patients in the PCOS-O group were younger (median [interquartile range]) than those in the PCOS-L group (15 [15-17] vs...
June 24, 2017: Gynecological Endocrinology
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