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Hyperandrogenism

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https://www.readbyqxmd.com/read/28522293/direct-action-of-adiponectin-ameliorates-increased-androgen-synthesis-and-reduces-insulin-receptor-expression-in-the-polycystic-ovary
#1
Anusha Singh, Puran Bora, Amitabh Krishna
Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder of reproductive age females, leading to infertility. Despite extensive research, the exact pathophysiology and treatment are lacking. The aim of the current study was to evaluate the direct role of adiponectin either alone or together with luteinizing hormone (LH) on sex hormone synthesis and changes in insulin receptor (IR) in the ovary of dehydroepiandrosterone (DHEA)-treated PCOS-mice. Immunohistochemical study showed decreased expression of adiponectin receptor (AdipoR1) in PCOS-ovary which correlated with increased synthesis of androgen and decreased expression of IR...
May 15, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28501702/brown-adipose-tissue-activation-by-rutin-ameliorates-polycystic-ovary-syndrome-in-rat
#2
Tao Hu, Xiaoxue Yuan, Rongcai Ye, Huiqiao Zhou, Jun Lin, Chuanhai Zhang, Hanlin Zhang, Gang Wei, Meng Dong, Yuanyuan Huang, Wonchung Lim, Qingsong Liu, Hyuek Jong Lee, Wanzhu Jin
Polycystic ovary syndrome (PCOS) is a complex endocrinopathy that is characterized by anovulation, hyperandrogenism and polycystic ovary. However, there is a lack of effective treatment for PCOS at present because the pathologic cause of PCOS has not been elucidated. Although it has been known that brown adipose tissue transplantation ameliorates PCOS by activating endogenous BAT, BAT transplantation is not applicable in clinic. Therefore, BAT activation with natural compound could be an effective treatment strategy for PCOS patients...
April 22, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28487735/variations-in-the-3-utr-of-the-cyp21a2-gene-in-heterozygous-females-with-hyperandrogenaemia
#3
Vassos Neocleous, Pavlos Fanis, Meropi Toumba, Alexia A P Phedonos, Michalis Picolos, Elena Andreou, Tassos C Kyriakides, George A Tanteles, Christos Shammas, Leonidas A Phylactou, Nicos Skordis
Heterozygosity for CYP21A2 mutations in females is possibly related to increased risk of developing clinical hyperandrogenism. The present study was designed to seek evidence on the phenotype-genotype correlation in female children, adolescents, and women with CYP21A2 mutations and variants in the 3'UTR region of the gene. Sixty-six patients out of the 169 were identified as carriers of CYP21A2 mutations. Higher values of stimulated 17 hydroxyprogesterone (17-OHP) levels were found in the carriers of the p...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28487551/high-free-androgen-index-is-associated-with-increased-risk-of-non-alcoholic-fatty-liver-disease-in-women-with-polycystic-ovary-syndrome-independently-of-obesity-and-insulin-resistance
#4
C Jie, W Chunhua, Z Yi, W Yuying, X Wendi, L Tzuchun, L Shengxian, W Lihua, Z Jun, S Yun, L Wei, T Tao
BACKGROUND/OBJECTIVECentral obesity and insulin resistance are common conditions in women with PCOS and in subjects with non-alcoholic fatty liver disease (NAFLD). However, few studies have addressed the association between hyperandrogenism (HA) and NAFLD. We aimed to determine whether variations in the free androgen index (FAI) might be associated with NAFLD prevalence.SUBJECTS/METHODSA cross-sectional study was performed including 400 Chinese women with PCOS and 100 age and body mass index (BMI)-matched women...
May 10, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28486649/hyperandrogenemia-reduces-endothelium-derived-hyperpolarizing-factor-mediated-relaxation-in-mesenteric-artery-of-female-rats
#5
Jay S Mishra, Amar S More, Gary D V Hankins, Sathish Kumar
Women with polycystic ovary syndrome (PCOS) often present with hyperandrogenemia along with vascular dysfunction and elevated blood pressure. In animal models of PCOS, anti-androgen treatment decreased blood pressure, indicating a key role for androgens in the development of hypertension. However, the underlying androgen-mediated mechanism that contributes to increased blood pressure is not known. This study determined whether elevated androgens affect endothelium-derived hyperpolarizing factor (EDHF)-mediated vascular relaxation responses through alteration in function of gap junctional proteins...
May 8, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28476694/analysis-on-endocrine-and-metabolic-features-of-different-phenotypes-of-polycystic-ovary-syndrome-patients
#6
Feng Li, Li Yao, Hong Wu, Shihong Cao
To discuss the manifestations of endocrine and metabolism for polycystic ovary syndrome patients with different phenotype. This study selected 226 cases of Rotterdam Standard diagnosed polycystic ovary syndrome patients in People's Hospital of Zhengzhou from October 2013 to February 2015. The control group was the 100 cases of non hyperandrogen menstrual women as the control group. Polycystic ovary syndrome included 4 phenotype: /or anovulatio (O) combined with hyperandrogenism (H) and polycystic ovary morphology (P), phenotype of O and P, phenotype of H and P, and phenotype of O and P...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28463030/use-of-cyproterone-acetate-ethinylestradiol-in-polycystic-ovary-syndrome-rationale-and-practical-aspects
#7
X Ruan, A Kubba, A Aguilar, A O Mueck
INTRODUCTION: Polycystic ovary syndrome (PCOS) is a common, heterogeneous disorder characterised by hyperandrogenic skin symptoms, irregular menstruation and subfertility, increased risk of endometrial malignancy, and increased risk of preventable diseases associated with metabolic syndrome. Cyproterone acetate (CPA) 2 mg, combined with ethinylestradiol (EE) 35 μg, is indicated for the treatment of moderate to severe acne related to androgen-sensitivity (with or without seborrhea) and/or hirsutism, in women of reproductive age...
May 2, 2017: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/28458903/using-kisspeptin-to-assess-gnrh-function-in-an-unusual-case-of-primary-amenorrhoea
#8
S Vimalesvaran, S Narayanaswamy, L Yang, J K Prague, A Buckley, A D Miras, S Franks, K Meeran, W S Dhillo
SUMMARY: Primary amenorrhoea is defined as the failure to commence menstruation by the age of 15 years, in the presence of normal secondary sexual development. The potential causes of primary amenorrhoea extend from structural to chromosomal abnormalities. Polycystic ovarian syndrome (PCOS) is a common cause of secondary amenorrhoea but an uncommon cause of primary amenorrhoea. An early and prompt diagnosis of PCOS is important, as up to 30% of these women are predisposed to glucose intolerance and obesity, with the subgroup of women presenting with primary amenorrhoea and PCOS displaying a higher incidence of metabolic dysfunction...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28456695/paratubal-cyst-size-correlates-with-obesity-and-dysregulation-of-the-wnt-signaling-pathway
#9
Jennifer E Dietrich, Oluyemisi Adeyemi, Julie Hakim, Xiomara Santos, Jennifer L Bercaw-Pratt, Juan C Bournat, Ching H Chen, Carolina J Jorgez
BACKGROUND: Paratubal cysts (PTC) occur in 7-10% of females, regardless of ages. Although common, PTCs often are found incidentally because of the potential for these cysts to be asymptomatic. SPECIFIC AIMS: To determine if PTC number and size correlated with signs of hyperandrogenism and obesity, as well as to investigate the molecular profiles of these PTCs in samples derived from adolescent females. METHODS: A prospective cohort study was performed in a single children's hospital...
April 26, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28454499/phenotypic-variation-in-anti-mullerian-hormone-amh-production-per-follicle-in-women-with-polycystic-ovary-syndrome-pcos-and-isolated-polycystic-ovarian-morphology-pcom-an-observational-cross-sectional-study
#10
Priya Bhide, Abhijit Kulkarni, Merve Dilgil, Puja Dhir, Amit Shah, Anil Gudi, Roy Homburg
This observational study compares the ratio of serum anti-Mullerian hormone (AMH) to the total antral follicle count (AFC) (as a marker of AMH production per follicle) in the various phenotypes of women with polycystic ovary syndrome (PCOS) and isolated polycystic ovarian morphology (PCOM). Two hundred and sixty-two women were recruited. Women with PCOS were divided into four phenotypes based on the diagnostic inclusion criteria of oligo-anovulation (OA), hyperandrogenism (HA) and polycystic ovarian morphology (PCOM)...
April 28, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28447864/the-use-of-cyproterone-acetate-ethinyl-estradiol-in-hyperandrogenic-skin-symptoms-a-review
#11
J Bitzer, T Römer, A Lopes da Silva Filho
INTRODUCTION: Hyperandrogenism affects approximately 10-20% of women of reproductive age. Hyperandrogenic skin symptoms such as hirsutism, acne, seborrhea and alopecia are associated with significant quality of life and psychological impairment. Women with abnormalities in androgen metabolism may have accompanying anovulation and/or polycystic ovary syndrome (PCOS), both of which have reproductive and metabolic implications if left untreated. Cyproterone acetate (CPA), combined with ethinylestradiol (EE), is indicated for the treatment of moderate to severe acne related to androgen-sensitivity (with or without seborrhea) and/or hirsutism, in women of reproductive age...
April 27, 2017: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/28443693/confounder-factors-masking-a-leydig-cell-ovarian-tumor-in-a-post-menopausal-woman-treated-for-androgen-positive-receptor-breast-cancer
#12
Felipe Scipião Moura, Flávia A Costa-Barbosa, Sydney Correia Leao, Sergio Mancini Nicolau, Claudio E Kater, Patrícia T Monteagudo
Post-menopause hyperandrogenism is a condition that needs careful evaluation. Aromatase inhibitors (AI), which are important in the management of positive estrogen breast cancer, and chronic kidney disease (CKD) can puzzle the evaluation of this condition. A postmenopause female with type-2 diabetes and advanced CKD was attended due to progressive virilization, which has started after the introduction of an AI for breast cancer 5 years earlier. Clinical and radiological investigation has confirmed a pure Leydig cell tumor as source of hyperandrogenism...
April 26, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28442024/intracytoplasmic-oxidative-stress-reverses-epigenetic-modifications-in-polycystic-ovary-syndrome
#13
Fatemeh Eini, Marefat Ghaffari Novin, Khojasteh Joharchi, Ahmad Hosseini, Hamid Nazarian, Abbas Piryaei, Arash Bidadkosh
In polycystic ovary syndrome (PCOS), substantial genetic and environmental alterations, along with hyperandrogenism, affect the quality of oocytes and decrease ovulation rates. To determine the mechanisms underlying these alterations caused specifically by an increase in plasma androgens, the present study was performed in experimentally-induced PCOS mice. As the study model, female B6D2F1 mice were treated with dehydroepiandrosterone (DHEA, 6mg per 100g bodyweight). After 20 days, oocytes at the germinal vesicle and metaphase II stages were retrieved from isolated ovaries and subsequent analyses of oocyte quality were performed for each mouse...
April 26, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28437788/high-prevalence-of-polycystic-ovary-syndrome-in-type-1-diabetes-mellitus-adolescents-is-there-a-difference-depending-on-the-nih-and-rotterdam-criteria
#14
Kanetee Busiah, Ana Colmenares, Maud Bidet, Nadia Tubiana-Rufi, Claire Levy-Marchal, Christine Delcroix, Paul Jacquin, Delphine Martin, Lila Benadjaoud, Evelyne Jacqz-Aigrain, Kathleen Laborde, Jean-Jacques Robert, Dinane Samara-Boustani, Michel Polak
BACKGROUND: Polycystic ovary syndrome (PCOS) is more frequently observed in type 1 diabetes mellitus (T1DM) adult women than in nondiabetic women. No such prevalence has yet been studied in adolescent girls with T1DM. AIM: The aim of this study was to evaluate the prevalence of PCOS in adolescent girls with T1DM and to determine the clinical and hormonal features associated with the disorder. METHODS: A cross-sectional study of 53 adolescent girls (gynecological age >2 years) referred for routine evaluation for T1DM was conducted...
April 24, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28434141/prescription-appropriateness-of-cyproterone-acetate-ethinylestradiol-in-primary-care-a-population-based-study-in-italy
#15
Francesco Lapi, Monica Simonetti, Iacopo Cricelli, Claudio Cricelli, Nicoletta Cassano, Gino A Vena
BACKGROUND AND OBJECTIVE: We evaluated the prescription appropriateness of cyproterone acetate in combination with ethinylestradiol (CPA/EE) in a primary care setting before and after the 2013 European Medicines Agency's (EMA) recommendation relating to the risk profile of CPA/EE. METHODS: Data were obtained from the Health Search IMS Health Longitudinal Patient Database (HSD). We compared the results from 2011 to 2012 with the results of 2014, namely before and after the 2013 EMA recommendation, and investigated the burden of concurrent use of CPA/EE and other hormonal contraceptives (HCs) and the reported indication at the time of CPA/EE prescription...
April 22, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28434104/mullerian-dysgenesis-a-critical-review-of-the-literature
#16
REVIEW
Souzana Choussein, Dimitrios Nasioudis, Dimitrios Schizas, Konstantinos P Economopoulos
PURPOSE: To present an update of the genetic, clinical, diagnostic, and therapeutic aspects of Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome. METHODS: Studies were considered eligible if they have evaluated patients with MRKH syndrome. Eligible articles were identified by a search of MEDLINE bibliographical database from 1950 to August 2016. A purely descriptive approach was adopted concerning all outcomes examined by the individual studies. RESULTS: MRKH syndrome is defined as congenital aplasia of the upper vagina and impairment of uterine development in normal 46XX females...
April 22, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28432801/weight-loss-in-obese-girls-with-polycystic-ovarian-syndrome-is-associated-with-a-decrease-of-anti-muellerian-hormone-concentrations
#17
Thomas Reinehr, Alexandra Kulle, Juliane Rothermel, Caroline Knop, Nina Lass, Christina Bosse, Paul-Martin Holterhus
OBJECTIVE: The Anti- Muellerian Hormone (AMH) has been reported as surrogate marker of antral follicles, which are the origins of hyperandrogenism in polycystic ovarian syndrome (PCOS). Therefore, AMH may be useful for the diagnosis of PCOS. The objective was to study the longitudinal changes in AMH concentrations in girls with and without PCOS. DESIGN: This is a longitudinal study of obese girls participating in a 1-year lifestyle intervention. PATIENTS: Forty obese girls aged 13-16 years (50% with PCOS) were included in the study...
April 22, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28432270/discriminating-between-virilizing-ovary-tumors-and-ovary-hyperthecosis-in-postmenopausal-women-clinical-data-hormonal-profiles-and-image-studies
#18
Viviane Dos Reis Vieira Yance, José Antonio Miguel Marcondes, Michelle Patrocíneo Rocha, Cristiano Roberto Grimaldi Barcellos, Wagner Silva Dantas, Ana Flavia Assis Avila, Ronaldo Hueb Baroni, Filomena Marino Carvalho, Sylvia Asaka Yamashita Hayashida, Berenice Bilharinho Mendonça, Sorahia Domenice
The presence of virilizing signs associated with high serum androgen levels in postmenopausal women is rare. Virilizing ovarian tumors (VOTs) and ovarian stromal hyperthecosis (OH) are the most common etiologies in virilized postmenopausal women. The differential diagnosis between these two conditions is often difficult. OBJECTIVE: To evaluate the contribution of clinical features, hormonal profiles and radiological studies to the differential diagnosis of VOT and OH. DESIGN: A retrospective study...
April 21, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28432106/prohibitin-induced-obesity-leads-to-anovulation-and-polycystic-ovary-in-mice
#19
Sudharsana Rao Ande, Khanh Hoa Nguyen, Yang Xin Zi Xu, Suresh Mishra
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder and the most common cause of female infertility. However, the etiology of the disease and the mechanisms by which this disorder progress remain unclear. Here we report that a transgenic obese mouse (Mito-Ob) developed by overexpressing prohibitin in adipocytes develops polycystic ovaries. Initially, the female Mito-Ob mice were equally fertile to their wild-type littermates. Mito-Ob mice begin to gain weight after puberty, become significantly obese between 3-6 months of age, and roughly 25% of them become infertile by 9 months of age...
April 21, 2017: Biology Open
https://www.readbyqxmd.com/read/28413474/obesity-contributes-more-to-increasing-apob-apoa1-ratio-than-hyperandrogenism-in-pcos-women-aged-20-38-years-in-china
#20
Jianhua Zheng, Qianqian Yin, Juanyi Cao, Bei Zhang
We investigated the association between the apolipoprotein B (ApoB)/apolipoprotein A1 (ApoA1) ratio and insulin resistance (IR), metabolic syndrome (MS) and its components in Chinese polycystic ovary syndrome (PCOS) adults. We also examined whether hyperandrogenism is involved in obesity-related metabolic abnormalities in a cohort of patients. A clinical cross-sectional study consisting of 532 Chinese PCOS adults aged 20-38 years was designed. Each subject underwent a physical examination and laboratory evaluation...
April 2017: Experimental and Therapeutic Medicine
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