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Hyperandrogenism

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https://www.readbyqxmd.com/read/29323690/premature-adrenarche
#1
Laura Novello, Phyllis W Speiser
Adrenarche is when a child's adrenal cortex starts to secrete adrenal androgen precursors. Dehydroepiandrosterone (DHEA) is the most abundant product of the adrenal cortex, and is a weak androgen agonist thought to be responsible for the clinical signs of pubarche by conversion to more potent androgens, testosterone, and dihydrotestosterone. DHEA's extra-adrenal sulfation product, dehydroepiandrosterone sulfate, is a stable marker for adrenal androgenic activity. Pubarche is the physical manifestation of androgenic hormone production, and includes the development of pubic and axillary hair, adult body odor, and acne...
January 1, 2018: Pediatric Annals
https://www.readbyqxmd.com/read/29310346/a-systematic-review-and-meta-analysis-of-the-impact-of-mineralocorticoid-receptor-antagonists-on-glucose-homeostasis
#2
Sandra Korol, Fannie Mottet, Sylvie Perreault, William L Baker, Michel White, Simon de Denus
BACKGROUND: Spironolactone, a nonselective mineralocorticoid receptor antagonist (MRA), may have a deleterious effect on glycemia. The objective of this review was to assess current knowledge on MRAs' influence (spironolactone, eplerenone, and canrenone) on glucose homeostasis and the risk of diabetes. METHOD: A systematic review was conducted using the Medline database on articles published from 1946 to January 2017 that studied the effects of MRAs on any glucose-related endpoints, without any restrictions regarding the participants' characteristics...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29298536/improvement-of-hyperandrogenism-oligo-ovulation-and-ovarian-morphology-in-a-patient-with-polycystic-ovary-syndrome-possible-role-of-ovarian-wedge-resection
#3
YuanYuan Zhang, SuiYu Luo, ZhiQuan Gong, XiaoYa Feng, ZiYi Wang, HaoHui Zhu, Yu Wang
Polycystic ovary syndrome (PCOS) is an endocrinological abnormality which typically presents as hormones disorder and/or infertility. It has received more and more attention in recent years though its pathogenesis is still unclear. Ovarian mucinous adenoma is a rarely pathological type which generates from epithelial cell of ovary. Here we present a patient with PCOS and ovarian mucinous tumor (occasionally discovered by cesarean section) receiving a complete relief after benign ovarian tumor excision. In this case, tumor excision played as a partial resection of ovary which might result in the normalized concentration level of hormones and morphology of ovary...
January 3, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29289990/prevalence-clinical-characteristics-and-reproductive-outcomes-of-polycystic-ovary-syndrome-in-older-women-referred-for-tertiary-fertility-care
#4
Samer Tannus, Justin Tan, Weon-Young Son, Michael-Haim Dahan
OBJECTIVE: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive age women. The clinical symptoms of PCOS vary with female age, as older women tend to have lower hyperandrogenic symptoms and many regain regular cycles. In this study, we aimed to estimate the prevalence of PCOS among older women referred for fertility care, describe their clinical characteristics, and compare their reproductive outcomes to those of matched control group. METHODS: A retrospective study conducted at a single reproductive center...
December 30, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29280371/improvement-in-anthropometric-parameters-after-rational-dietary-intervention-in-women-with-polycystic-ovary-syndrom-as-the-best-method-to-support-treatment
#5
Małgorzata Szczuko, Inez Malarczyk, Marta Zapałowska-Chwyć
Background: Polycystic ovary syndrome (PCOS) is a disorder often occurring in women at reproductive age. An important factor in PCOS pathogenesis is insulin resistance, which pronounces hyperandrogenism and leads to the development of various metabolic disorders Objectives: The aim of this study is to determine the effect of reduction diet with low glycemic index (GI) on anthropometric parameters of women with PCOS and the assessment of the effectiveness of the diet on body mass and adipose tissue reduction Material and methods: The study was performed on 24 women with PCOS diagnosed with Rotterdam’s criteria...
2017: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/29280221/what-is-adolescent-polycystic-ovary-syndrome
#6
REVIEW
Alexia S Peña, Michael Metz
The diagnostic criteria for adolescent polycystic ovary syndrome (PCOS) has been derived from adult criteria, which makes diagnosis challenging as criteria include normal physiological events that occur during puberty such as acne, hirsutism, menstrual irregularities, high androgen levels and polycystic ovarian morphology on pelvic ultrasound. The only criteria that applies from the adult criteria is exclusion of other conditions that mimic PCOS. Clinical findings consistent with hyperandrogenaemia during adolescence include inflammatory acne, hirsutism, alopecia and/or menstrual irregularities, which are severe and present 2 years after menarche...
December 27, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29277707/the-in-vitro-metabolism-of-11%C3%AE-hydroxyprogesterone-and-11-ketoprogesterone-to-11-ketodihydrotestosterone-in-the-backdoor-pathway
#7
Desmaré van Rooyen, Rachelle Gent, Lise Barnard, Amanda C Swart
Increased circulating 11β-hydroxyprogesterone (11OHP4), biosynthesised in the human adrenal, is associated with 21-hydroxylase deficiency in congenital adrenal hyperplasia. 17α-hydroxyprogesterone levels are also increased, with the steroid's metabolism to dihydrotestosterone in the backdoor pathway contributing to hyperandrogenic clinical conditions. In this study we investigated the in vitro biosynthesis and downstream metabolism of 11OHP4. Both cytochrome P450 11β-hydroxylase and aldosterone synthase catalyse the biosynthesis of 11OHP4 from progesterone (P4) which is converted to 11-ketoprogesterone (11KP4) by 11β-hydroxysteroid dehydrogenase type 2, while type 1 readily catalysed the reverse reaction...
December 23, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29273198/enlarged-adipocytes-in-subcutaneous-adipose-tissue-associated-to-hyperandrogenism-and-visceral-adipose-tissue-volume-in-women-with-polycystic-ovary-syndrome
#8
Bárbara Echiburú, Francisco Pérez-Bravo, José E Galgani, Daniel Sandoval, Carolina Saldías, Nicolás Crisosto, Manuel Maliqueo, Teresa Sir-Petermann
CONTEXT: Polycystic ovary syndrome (PCOS) is an androgen excess disorder associated with obesity and adipose tissue disturbances. Our aim was to evaluate gene expression of adipocytokines and adipocyte characteristics in abdominal subcutaneous adipose tissue (SAT) of PCOS women. DESIGN: Twelve PCOS (PCOSw) and 12 control (Cw) premenopausal women (BMI 20-35 kg/m2) were included, with measurements of whole-body composition assessed by dual-energy X-ray absorptiometry, and abdominal subcutaneous and visceral adipose tissue (VAT) volume, by magnetic resonance imaging...
February 2018: Steroids
https://www.readbyqxmd.com/read/29273090/exercise-and-reproductive-function-in-polycystic-ovary-syndrome-protocol-of-a-systematic-review
#9
Isis Kelly Dos Santos, Romilson de Lima Nunes, Gustavo Mafaldo Soares, Tecia Maria de Oliveira Maranhão, Paulo Moreira Silva Dantas
BACKGROUND: Although many post-participation outcomes in different types of physical training (e.g., aerobic and strength) have been previously investigated for the treatment of polycystic ovary syndrome, there is no recent systematic review of the relationship between various types of intervention and the reproductive function of women with PCOS. The current paper describes a systematic review protocol on the benefits of physical exercise and dietary or drug interventions on endocrinological outcomes in women with PCOS...
December 22, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29242633/sexual-function-in-women-with-polycystic-ovary-syndrome-and-their-hormonal-and-clinical-correlations
#10
Fatemeh Nasiri Amiri, Fahimeh Ramezani Tehrani, Sedighe Esmailzadeh, Maryam Tohidi, Fereidoun Azizi, Zahra Basirat
Polycystic ovary syndrome (PCOS) appears to be related to sexual dysfunction, especially if associated with obvious clinical and hormonal signs of hyperandrogenism. The objective of this study was to determine the correlation of PCOS and its hormonal and clinical parameters with sexual function. This prospective, cross-sectional study conducted on 18-45-year-old PCOS women (according to the Rotterdam criteria), who were referred to the Reproductive Endocrinology Research Center, Iran, was invited to participate from January 2012 to December 2015...
December 15, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/29234256/congenital-malformations-of-the-reproductive-tract-in-a-patient-with-poland-syndrome-is-there-a-connection
#11
Tian Meng, Ming Bai, Ru Zhao
Background: Poland syndrome and Müllerian duct agenesis (Mayer-Rokitansky-Küster-Hauser(MRKH)-like syndrome) are two rare congenital anomalies with unclear etiology. Case Report: An 18-year-old female presented with hypoplasia of the left pectoralis muscles and subcutaneous tissue, hypoplasia of the left breast and nipple, and dextrocardia, typical in those with a severe form of Poland syndrome. She also showed aplasia of the vagina and uterus, bilateral ovarian agenesis, and hyperandrogenism, presenting as MRKH-like syndrome...
October 2017: Breast Care
https://www.readbyqxmd.com/read/29233731/do-different-diagnostic-criteria-cause-impact-polycystic-ovary-syndrome-diagnosis-for-adolescents
#12
Sinem Akgül, Yasemin Düzçeker, Nuray Kanbur, Orhan Derman
OBJECTIVE: While early diagnosis of polycystic ovary syndrome (PCOS) in adolescents may allow for earlier treatment and prevention of chronic disorders, incorrect or premature diagnosis carries risks of unnecessary treatment and psychological distress. There is no consensus concerning which diagnostic criteria to use for adolescents and current criteria vary. The objective of this study was to determine whether using different diagnostic criteria will affect PCOS diagnosis in adolescents...
December 9, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29232372/attenuated-expression-of-mtr-in-both-prenatally-androgenized-mice-and-women-with-the-hyperandrogenic-phenotype-of-pcos
#13
Lei Lei, Lijun Ding, Jing Su, Mengyuan Liu, Qingqing Shi, Jianjun Zhou, Haixiang Sun, Guijun Yan
Polycystic ovary syndrome (PCOS) is a common endocrine, metabolic and heterogeneous disorder in women of reproductive age, the exact etiology of which remains unknown. To unravel the molecular mechanisms underlying the hyperandrogenic phenotype of PCOS, prenatally androgenized (PNA) mice were used to mimic this phenotype in women with PCOS. Using microarray analysis, 1188 differentially expressed genes, including 671 upregulated and 517 downregulated genes, were identified in ovaries from PNA mice. Five differentially expressed genes (Aldh1a7, Bhmt, Mtr, Nrcam, Ptprg) were validated, and decreased MTR expression was shown in ovaries of PNA mice...
2017: PloS One
https://www.readbyqxmd.com/read/29230843/cardiac-function-in-pediatric-patients-with-congenital-adrenal-hyperplasia-due-to-21-hydroxylase-deficiency
#14
Christiaan F Mooij, Milanthy S Pourier, Gert Weijers, Chris L de Korte, Zina Fejzic, Hedi L Claahsen van der Grinten, Livia Kapusta
BACKGROUND: Hyperandrogenism and exogenous glucocorticoid excess may cause unfavorable changes in the cardiovascular risk profile of patients with congenital adrenal hyperplasia (CAH). OBJECTIVE: To evaluate the cardiac function in pediatric patients with CAH. PATIENTS AND METHODS: 27 pediatric patients with CAH, aged 8-16 years, were evaluated by physical examination, electrocardiogram (ECG), conventional echocardiography, tissue Doppler imaging and two-dimensional (2D) myocardial strain (rate) imaging...
December 11, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29217212/ovarian-morphology-by-transabdominal-ultrasound-correlates-with-reproductive-and-metabolic-disturbance-in-adolescents-with-pcos
#15
Beth W Rackow, Heidi Vanden Brink, Lynwood Hammers, Clare A Flannery, Marla E Lujan, Tania S Burgert
PURPOSE: To determine whether ovarian morphology imaged using transabdominal ultrasonography reflects clinical and metabolic features in adolescents with polycystic ovary syndrome (PCOS). METHODS: A retrospective pilot study was conducted in 33 adolescents (12-18 years) with PCOS as defined by hyperandrogenism and irregular cycles. Adolescents underwent the following assessments at a random time during the menstrual cycle: transabdominal ultrasonography, physical examination (height, weight, and systolic and diastolic blood pressure), fasting hormonal tests (free, percent free, and total testosterone, androstenedione, follicle stimulating hormone, luteinizing hormone), and metabolic tests (including an oral glucose tolerance test, fasting and 2-hour insulin and glucose, homeostatic model assessment of insulin resistance, and whole-body insulin sensitivity index)...
December 5, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29204121/abnormal-cftr-affects-glucagon-production-by-islet-%C3%AE-cells-in-cystic-fibrosis-and-polycystic-ovarian-syndrome
#16
Wen Qing Huang, Jing Hui Guo, Chun Yuan, Yu Gui Cui, Fei Yang Diao, Mei Kuen Yu, Jia Yin Liu, Ye Chun Ruan, Hsiao Chang Chan
Glucagon, produced by islet α cells, functions to increase blood glucose. Abnormal glucose levels are often seen in cystic fibrosis (CF), a systematic disease caused by mutations of the CF transmembrane conductance regulator (CFTR), and in polycystic ovarian syndrome (PCOS), an endocrine disorder featured with hyperandrogenism affecting 5-10% women of reproductive age. Here, we explored the role of CFTR in glucagon production in α cells and its possible contribution to glucagon disturbance in CF and PCOS...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29196492/high-fat-diet-exposure-from-pre-pubertal-age-induces-pcos-in-rats
#17
Roshni S Patel, Gaurang B Shah
Polycystic ovary syndrome (PCOS) is associated with hyperandrogenism, oligo-anovulation, polycystic ovaries and metabolic syndrome. Many researchers reported that PCOS often starts with menarche in adolescents. Presently available animal models focuses on ovarian but not metabolic features of PCOS. Therefore, we hypothesized that high fat diet feeding to pre-pubertal female rats results in both reproductive and metabolic features of PCOS. Pre-pubertal female rats were divided into two groups: group I received normal pellet diet and group II received high fat diet (HFD)...
December 1, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29193229/identification-of-micrornas-and-genes-associated-with-hyperandrogenism-in-the-follicular-fluid-of-women-with-polycystic-ovary-syndrome
#18
Yunping Xue, Juan Lv, Pengfei Xu, Lin Gu, Jian Cao, Lingling Xu, Kai Xue, Qian Li
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disease, which is characterized by hyperandrogenism (HA), chronic anovulation, polycystic ovaries, insulin resistance and obesity. At present, the mechanism by which PCOS/HA occurs has not been fully elucidated, thus, the mechanisms behind and interventions for HA in PCOS are current hot topics in research. MiRNAs have recently been shown to serve as diagnostic or prognostic biomarkers in patients with cancer...
November 28, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29191127/the-association-between-the-environmental-endocrine-disruptor-bisphenol-a-and-polycystic-ovary-syndrome-a-systematic-review-and-meta-analysis
#19
Ying Hu, Shu Wen, Dongzhi Yuan, Le Peng, Rujun Zeng, Zhilan Yang, Qi Liu, Liangzhi Xu, Deying Kang
OBJECTIVE: To investigate the association between bisphenol A (BPA) and polycystic ovary syndrome (PCOS). METHODS: A systematic review and meta-analysis using STATA software for observational studies. RESULTS: Nine studies involving 493 PCOS patients and 440 controls were included in this review. The meta-analysis demonstrated that PCOS patients had significantly higher BPA levels compared with control groups (standardized mean difference (SMD): 2...
November 30, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29186914/the-contribution-of-new-areas-to-the-total-hirsutism-scores-in-basrah-hirsute-women
#20
Rudha Naser Hussein, Khalil Ismail Al Hamdi, Abbas Ali Mansour
BACKGROUND: Hirsutism is the presence of excessive growth of terminal hair in a female in the male-like pattern. It is the most common indicator of hyperandrogenism. The primary objective of this study was to evaluate the clinical impact of new androgens sensitive skin area to total body hirsutism score. METHODS: This was cross-sectional study. Most of the patients in this study group (n = 300) were women of reproductive age group (20-39 years) with a mean age of 26...
November 27, 2017: Diseases (Basel)
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