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https://www.readbyqxmd.com/read/28087121/upper-extremity-outcome-measures-for-collagen-vi-related-myopathy-and-lama2-related-muscular-dystrophy
#1
Roxanna M Bendixen, Jocelyn Butrum, Mina S Jain, Rebecca Parks, Bonnie Hodsdon, Carmel Nichols, Michelle Hsia, Leslie Nelson, Katherine C Keller, Michelle McGuire, Jeffrey S Elliott, Melody M Linton, Irene C Arveson, Fatou Tounkara, Ruhi Vasavada, Elizabeth Harnett, Monal Punjabi, Sandra Donkervoort, Jahannaz Dastgir, Meganne E Leach, Anne Rutkowski, Melissa Waite, James Collins, Carsten G Bönnemann, Katherine G Meilleur
Congenital muscular dystrophy (CMD) comprises a rare group of genetic muscle diseases that present at birth or early during infancy. Two common subtypes of CMD are collagen VI-related muscular dystrophy (COL6-RD) and laminin alpha 2-related dystrophy (LAMA2-RD). Traditional outcome measures in CMD include gross motor and mobility assessments, yet significant motor declines underscore the need for valid upper extremity motor assessments as a clinical endpoint. This study validated a battery of upper extremity measures in these two CMD subtypes for future clinical trials...
December 5, 2016: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/28079306/open-dislocation-of-ankle-without-fracture-treated-with-an-external-fixator
#2
Emrah Sayit, Asli Tanrivermis Sayit, Elcin Zan
Ankle dislocations are orthopedic emergencies that require immediate treatment to avoid neurovascular impairment. They are usually accompanied by one or more comminuted fractures of the ankle mortis. In rare circumstances, such as high-energy trauma, the ankle dislocations may not be accompanied by concomitant malleolar fractures and, thus, are named "pure ankle dislocations". We presented a very rare and interesting case of an open medial dislocation of the ankle without associated fracture in an 18-year-old man with no known predisposing risk factors...
January 12, 2017: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28077637/role-of-litopenaeus-vannamei-yin-yang-1-in-the-regulation-of-the-white-spot-syndrome-virus-immediate-early-gene-ie1
#3
Ping-Han Huang, Ting-Yi Huang, Pei-Si Cai, Li-Kwan Chang
: Yin Yang 1 (YY1) is a multifunctional zinc-finger transcription factor that regulates many key cellular processes. In this study, we report the cloning of YY1 from shrimp, Litopenaeus vannamei, (LvYY1). The study shows that LvYY1 is ubiquitously expressed in shrimp tissues, and knockdown of LvYY1 expression by dsRNA injection in WSSV-infected shrimp reduced both mRNA levels of the WSSV immediate-early gene, ie1, as well as overall copy numbers of the WSSV genome. The cumulative mortality of infected shrimp also declined with LvYY1 dsRNA injection...
January 11, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28075356/targeting-micrornas-in-cancer-gene-therapy
#4
REVIEW
Weidan Ji, Bin Sun, Changqing Su
MicroRNAs (miRNAs) are a kind of conserved small non-coding RNAs that participate in regulating gene expression by targeting multiple molecules. Early studies have shown that the expression of miRNAs changes significantly in different tumor tissues and cancer cell lines. It is well acknowledged that such variation is involved in almost all biological processes, including cell proliferation, mobility, survival and differentiation. Increasing experimental data indicate that miRNA dysregulation is a biomarker of several pathological conditions including cancer, and that miRNA can exert a causal role, as oncogenes or tumor suppressor genes, in different steps of the tumorigenic process...
January 9, 2017: Genes
https://www.readbyqxmd.com/read/28074430/the-monomeric-gtpase-raba2-is-required-for-progression-and-maintenance-of-membrane-integrity-of-infection-threads-during-root-nodule-symbiosis
#5
Virginia Dalla Via, Soledad Traubenik, Claudio Rivero, O Mario Aguilar, María Eugenia Zanetti, Flavio Antonio Blanco
Progression of the infection canal that conducts rhizobia to the nodule primordium requires a functional Rab GTPase located in Golgi/trans-Golgi that also participate in root hair polar growth. Common bean (Phaseolus vulgaris) symbiotically associates with its partner Rhizobium etli, resulting in the formation of root nitrogen-fixing nodules. Compatible bacteria can reach cortical cells in a tightly regulated infection process, in which the specific recognition of signal molecules is a key step to select the symbiotic partner...
January 10, 2017: Plant Molecular Biology
https://www.readbyqxmd.com/read/28073181/participation-restrictions-in-ambulatory-als-patients-physical-and-psychological-factors
#6
Annerieke C van Groenestijn, Carin D Schröder, Esther T Kruitwagen-van Reenen, Leonard H van den Berg, Johanna M A Visser-Meily
INTRODUCTION: The aim of this study was to assess the prevalence of participation restrictions in ambulatory patients with amyotrophic lateral sclerosis (ALS) and to identify physical and psychological contributory factors. METHODS: In this cross-sectional study, self-reported participation restrictions of 72 ambulatory ALS patients were assessed using the social health status dimension (SIPSOC) of the Sickness Impact Profile (SIP-68). Associations between SIPSOC and physical functioning, psychological factors, and demographic factors were analyzed using hierarchical regression analyses...
January 10, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28072901/achilles-tendon-repair-using-the-internalbrace%C3%A2-principle
#7
Graeme P Hopper, Gordon M Mackay
Despite extensive research, the management of acute ruptures of the Achilles tendon remains an area of controversy, and there is no consensus regarding the optimal treatment. An InternalBrace™ (Arthrex, Inc., Naples, Florida) is a ligament augmentation repair using high strength sutures/tape and knotless bone anchors which encourages healing and allows early mobilization. This article describes, with video illustration, a knotless Achilles tendon repair technique using the InternalBrace™ principle.
January 10, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28072735/localized-type-volkmann-s-contracture-treated-with-tendon-transfer-and-tension-reduced-early-mobilization-a-case-report
#8
Yoshio Kaji, Osamu Nakamura, Konosuke Yamaguchi, Sachiko Tobiume, Tetsuji Yamamoto
RATIONALE: For localized type Volkmann's contracture, in which degeneration of the flexor digitorum profundus (FDP) muscle to one or two fingers and restriction of finger extension occur, dissection or excision of the affected muscle is usually recommended. However, these surgical procedures need relatively wide exposure of the muscle, because the FDP muscle is in the deep portion of the forearm. PATIENT CONCERNS: In this report, the case of a 35-year-old woman with localized type Volkmann's contracture is presented...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28068906/cherish-collaboration-for-hospitalised-elders-reducing-the-impact-of-stays-in-hospital-protocol-for-a-multi-site-improvement-program-to-reduce-geriatric-syndromes-in-older-inpatients
#9
Alison M Mudge, Merrilyn D Banks, Adrian G Barnett, Irene Blackberry, Nicholas Graves, Theresa Green, Gillian Harvey, Ruth E Hubbard, Sharon K Inouye, Sue Kurrle, Kwang Lim, Prue McRae, Nancye M Peel, Jessica Suna, Adrienne M Young
BACKGROUND: Older inpatients are at risk of hospital-associated geriatric syndromes including delirium, functional decline, incontinence, falls and pressure injuries. These contribute to longer hospital stays, loss of independence, and death. Effective interventions to reduce geriatric syndromes remain poorly implemented due to their complexity, and require an organised approach to change care practices and systems. Eat Walk Engage is a complex multi-component intervention with structured implementation, which has shown reduced geriatric syndromes and length of stay in pilot studies at one hospital...
January 9, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28068641/oil-palm-drought-inducible-dreb1-induced-expression-of-dre-crt-and-non-dre-crt-containing-genes-in-lowland-transgenic-tomato-under-cold-and-peg-treatments
#10
Azzreena Mohamad Azzeme, Siti Nor Akmar Abdullah, Maheran Abd Aziz, Puteri Edaroyati Megat Wahab
Dehydration-responsive element binding (DREB) transcription factor plays an important role in controlling the expression of abiotic stress responsive genes. An intronless oil palm EgDREB1 was isolated and confirmed to be a nuclear localized protein. Electrophoretic mobility shift and yeast one-hybrid assays validated its ability to interact with DRE/CRT motif. Its close evolutionary relation to the dicot NtDREB2 suggests a universal regulatory role. In order to determine its involvement in abiotic stress response, functional characterization was performed in oil palm seedlings subjected to different levels of drought severity and in EgDREB1 transgenic tomato seedlings treated by abiotic stresses...
December 27, 2016: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28063476/short-communication-immunohistochemical-localization-of-the-immune-cell-marker-cd68-in-bovine-adipose-tissue-impact-of-tissue-alterations-and-excessive-fat-accumulation-in-dairy-cows
#11
S Häussler, D Germeroth, L Laubenthal, L F Ruda, J Rehage, S Dänicke, H Sauerwein
With the onset of lactation energy from feed intake is mostly insufficient to meet the requirements of dairy cows. Lipid mobilization from adipose tissue (AT) could lead to a compromised inflammatory response enhancing the incidence for diseases. In addition, tissue alterations can occur, displaying areas of necrosis and inflammation. Furthermore, over-conditioned cows mobilizing more lipids from AT than thin cows are prone to develop metabolic disorders. This might lead to an increased infiltration of phagocytic immune cells into AT...
January 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/28063264/preimplantation-3d-ultrasound-current-uses-and-challenges
#12
Sushila Arya, Sanja Kupesic Plavsic
The preimplantation ultrasound (US) refers to targeted imaging of the uterus and adnexa prior to assisted reproductive techniques (ART) to optimize the infertility treatment outcomes. After a thorough evidence based literature review, we propose the use of transvaginal three-dimensional (3D) US during the early follicular phase. A systematic approach for 3D US examination consists of a detailed examination of the uterine shape, size and contour, evaluation of the endometrial thickness, volume, pattern and vascularity, and assessment of the junctional zone regularity, echogenicity and thickness...
January 7, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28061951/role-and-contribution-of-pulmonary-cd103-dendritic-cells-in-the-adaptive-immune-response-to-mycobacterium-tuberculosis
#13
Vanessa Hui Qi Koh, See Liang Ng, Michelle Lay Teng Ang, Wenwei Lin, Christiane Ruedl, Sylvie Alonso
Despite international control programmes, the global burden of tuberculosis remains enormous. Efforts to discover novel drugs have largely focused on targeting the bacterium directly. Alternatively, manipulating the host immune response may represent a valuable approach to enhance immunological clearance of the bacilli, but necessitates a deeper understanding of the immune mechanisms associated with protection against Mycobacterium tuberculosis infection. Here, we examined the various dendritic cells (DC) subsets present in the lung and draining lymph nodes (LN) from mice intra-tracheally infected with M...
January 2017: Tuberculosis
https://www.readbyqxmd.com/read/28056974/an-evaluation-of-the-telehealth-facilitation-of-diabetes-and-cardiovascular-care-in-remote-australian-indigenous-communities-protocol-for-the-telehealth-eye-and-associated-medical-services-network-teamsnet-project-a-pre-post-study-design
#14
Laima Brazionis, Alicia Jenkins, Anthony Keech, Chris Ryan, Sven-Erik Bursell
BACKGROUND: Despite substantial investment in detection, early intervention and evidence-based treatments, current management strategies for diabetes-associated retinopathy and cardiovascular disease are largely based on real-time and face-to-face approaches. There are limited data re telehealth facilitation in type 2 diabetes management. Therefore, we aim to investigate efficacy of telehealth facilitation of diabetes and cardiovascular disease care in high-risk vulnerable Aboriginal and Torres Strait Islanders in remote/very remote Australia...
January 5, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28056159/obturator-artery-injury-resulting-in-massive-hemorrhage-from-a-low-energy-pubic-ramus-fracture
#15
Mark K Solarz, Justin M Kistler, Saqib Rehman
Pelvic ring fractures are common in the elderly population and are usually a result of low-energy trauma, such as falls from standing. In most cases, low-energy pelvic ring injuries can be treated with appropriate analgesia and early mobilization. Arterial injury resulting in hemodynamic instability from a low-energy pelvic ring injury is rare but, given the poor compliance of vessels in the elderly population, possible. These patients must be carefully monitored after the initial injury. The purpose of this report is to describe an elderly patient who sustained a superior pubic ramus fracture and arterial injury following a low-energy fall from standing that required angiographic intervention...
January 5, 2017: Orthopedics
https://www.readbyqxmd.com/read/28054834/long-term-restrictions-in-participation-in-stroke-survivors-under-and-over-70-years-of-age
#16
Joris A de Graaf, Maria L van Mierlo, Marcel W M Post, Wilco P Achterberg, L Jaap Kappelle, Johanna M A Visser-Meily
PURPOSE: This study aims to (1) assess differences in participation restrictions between stroke survivors aged under and over 70 years and (2) identify predictors associated with favorable and unfavorable long-term participation in both age groups. METHODS: Prospective cohort study in which 326 patients were assessed at stroke onset, two months and one year after stroke. The Utrecht Scale for Evaluation of Rehabilitation-Participation (USER-Participation) was used to measure participation restrictions one year after stroke...
January 5, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28051969/effects-of-adding-neuromuscular-electrical-stimulation-to-traditional-military-amputee-rehabilitation
#17
Laura A Talbot, Emily Brede, E Jeffrey Metter
BACKGROUND: Traumatic transtibial amputations lead to an early decline in the use and weight bearing of the residual limb. These changes result in progressive quadriceps muscle atrophy with strength loss that affects standing and walking. Neuromuscular electrical stimulation (NMES) may be useful as an adjunct to amputee prosthetic rehabilitation to maintain quadriceps muscle strength and mass. The objective of this pilot study was to compare the effects of a home-based NMES rehabilitation program plus the traditional military amputee rehabilitation program (TMARP) to the effects of TMARP alone on quadriceps muscle strength, functional mobility, and pain in military service members after a combat-related lower extremity amputation...
January 2017: Military Medicine
https://www.readbyqxmd.com/read/28047744/we-a-201-01-memorial-introduction
#18
C Marshall
: Chris Marshall: Memorial Introduction Donald Edmonds Herbert Jr., or Don to his colleagues and friends, exemplified the "big tent" vision of medical physics, specializing in Applied Statistics and Dynamical Systems theory. He saw, more clearly than most, that "Making models is the difference between doing science and just fooling around [ref Woodworth, 2004]". Don developed an interest in chemistry at school by "reading a book" - a recurring theme in his story. He was awarded a Westinghouse Science scholarship and attended the Carnegie Institute of Technology (later Carnegie Mellon University) where his interest turned to physics and led to a BS in Physics after transfer to Northwestern University...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047091/we-a-201-02-modern-statistical-modeling
#19
A Niemierko
: Chris Marshall: Memorial Introduction Donald Edmonds Herbert Jr., or Don to his colleagues and friends, exemplified the "big tent" vision of medical physics, specializing in Applied Statistics and Dynamical Systems theory. He saw, more clearly than most, that "Making models is the difference between doing science and just fooling around [ref Woodworth, 2004]". Don developed an interest in chemistry at school by "reading a book" - a recurring theme in his story. He was awarded a Westinghouse Science scholarship and attended the Carnegie Institute of Technology (later Carnegie Mellon University) where his interest turned to physics and led to a BS in Physics after transfer to Northwestern University...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046561/we-a-201-00-anne-and-donald-herbert-distinguished-lectureship-on-modern-statistical-modeling
#20
Joseph Deasy
: Chris Marshall: Memorial Introduction Donald Edmonds Herbert Jr., or Don to his colleagues and friends, exemplified the "big tent" vision of medical physics, specializing in Applied Statistics and Dynamical Systems theory. He saw, more clearly than most, that "Making models is the difference between doing science and just fooling around [ref Woodworth, 2004]". Don developed an interest in chemistry at school by "reading a book" - a recurring theme in his story. He was awarded a Westinghouse Science scholarship and attended the Carnegie Institute of Technology (later Carnegie Mellon University) where his interest turned to physics and led to a BS in Physics after transfer to Northwestern University...
June 2016: Medical Physics
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