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https://www.readbyqxmd.com/read/28445875/double-incision-approach-and-early-rehabilitation-in-a-complicated-bicondylar-br-tibial-plateau-fracture-a-case-report-br-br
#1
Saverio Affatato, Maurizio Montalti, Claudio Masetti, Federico Giardina, Alessandra Sudanese
OBJECTIVE: The main goal of this case was to report the treatment of bicondylar fractures of the tibial plateau and the restoration of the metaphyseo-diaphyseal dissociation. CLINICAL PRESENTATION AND INTERVENTION: A 54-year old man who was cycling had a road accident that caused a closed fracture of the right tibial plateau and proximal fibula diagnosed by x-rays. Patient had surgical procedure and was immobilized with a long-leg splint for 4 weeks. After immobilization, aggressive rehabilitation was done...
April 26, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/28445733/nf-%C3%AE%C2%BAb-immunity-in-the-brain-determines-fly-lifespan-in-healthy-aging-and-age-related-neurodegeneration
#2
Ilias Kounatidis, Stanislava Chtarbanova, Yang Cao, Margaret Hayne, Dhruv Jayanth, Barry Ganetzky, Petros Ligoxygakis
During aging, innate immunity progresses to a chronically active state. However, what distinguishes those that "age well" from those developing age-related neurological conditions is unclear. We used Drosophila to explore the cost of immunity in the aging brain. We show that mutations in intracellular negative regulators of the IMD/NF-κB pathway predisposed flies to toxic levels of antimicrobial peptides, resulting in early locomotor defects, extensive neurodegeneration, and reduced lifespan. These phenotypes were rescued when immunity was suppressed in glia...
April 25, 2017: Cell Reports
https://www.readbyqxmd.com/read/28445540/individuals-with-severely-impaired-vision-can-learn-useful-orientation-and-mobility-skills-in-virtual-streets-and-can-use-them-to-improve-real-street-safety
#3
Ellen Lambert Bowman, Lei Liu
Virtual reality has great potential in training road safety skills to individuals with low vision but the feasibility of such training has not been demonstrated. We tested the hypotheses that low vision individuals could learn useful skills in virtual streets and could apply them to improve real street safety. Twelve participants, whose vision was too poor to use the pedestrian signals were taught by a certified orientation and mobility specialist to determine the safest time to cross the street using the visual and auditory signals made by the start of previously stopped cars at a traffic-light controlled street intersection...
2017: PloS One
https://www.readbyqxmd.com/read/28445352/consensus-review-of-optimal-perioperative-care-in-breast-reconstruction-enhanced-recovery-after-surgery-eras-society-recommendations
#4
Claire Temple-Oberle, Melissa A Shea-Budgell, Mark Tan, John L Semple, Christiaan Schrag, Marcio Barreto, Phillip Blondeel, Jeremy Hamming, Joseph Dayan, Olle Ljungqvist
BACKGROUND: Enhanced recovery following surgery can be achieved through the introduction of evidence-based perioperative maneuvers. This review aims to present a consensus for optimal perioperative management of patients undergoing breast reconstructive surgery and to provide evidence-based recommendations for an enhanced perioperative protocol. METHODS: A systematic review of meta-analyses, randomized controlled trials, and large prospective cohorts was conducted for each protocol element...
May 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28444506/preoperative-risk-factors-for-prolonged-postoperative-ileus-after-colorectal-resection
#5
Albert M Wolthuis, Gabriele Bislenghi, Maarten Lambrecht, Steffen Fieuws, Anthony de Buck van Overstraeten, Guy Boeckxstaens, André D'Hoore
PURPOSE: Prolonged postoperative ileus (PPOI) after colorectal resection significantly impacts patients' recovery and hospital stay. Because treatment options for PPOI are limited, it is necessary to focus on prevention strategies. The aim of this study is to investigate risk factors associated with PPOI in patients undergoing colorectal surgery. METHODS: Data from all consecutive patients who underwent colorectal resection in our department were retrospectively analyzed from a prospective database over a 9-month period...
April 25, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28443167/elderly-patients-achieving-clinical-and-radiological-outcomes-comparable-with-those-of-younger-patients-following-minimally-invasive-transforaminal-lumbar-interbody-fusion
#6
Joshi Nikhil N, Joel Wei-An Lim, William Yeo, Wai-Mun Yue
STUDY DESIGN: Retrospective analysis of prospective database. PURPOSE: To compare 2-year clinical and radiological outcomes after minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) among "middle-age" (50-64.99 years), "young-old" (65-74.99 years), and "old-old" (>75 years) patients. OVERVIEW OF LITERATURE: Owing to higher perioperative morbidity and mortality rates, elderly patients with degenerative lumbar conditions are occasionally denied surgical care, even after conservative treatment failure...
April 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/28441551/treating-normal-early-gestation-placentae-with-preeclamptic-sera-produces-extracellular-micro-and-nano-vesicles-that-activate-endothelial-cells
#7
Xirong Xiao, Fengyi Xiao, Mingzhi Zhao, Mancy Tong, Michelle R Wise, Peter R Stone, Lawrence W Chamley, Qi Chen
OBJECTIVES: Preeclampsia is characterised by systemic endothelial cell dysfunction thought to be triggered by toxic/dangerous factors from the placenta, including placental extracellular vesicles (EVs). Why placental EVs become toxic is unknown. We previously reported that preeclamptic sera produced toxic/dangerous placental macrovesicles but whether small EVs are also toxic/dangerous in preeclampsia is unknown. STUDY DESIGN: First trimester placental explants were treated with 10% preeclamptic or control sera (n=10) for 24h...
April 14, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28441108/novel-clades-of-the-hu-ihf-superfamily-point-to-unexpected-roles-in-the-eukaryotic-centrosome-chromosome-partitioning-and-biological-conflicts
#8
A Maxwell Burroughs, Gurmeet Kaur, Dapeng Zhang, L Aravind
The HU superfamily of proteins, with a unique DNA-binding mode, has been extensively studied as the primary chromosome-packaging protein of the bacterial superkingdom. Representatives also play a role in DNA-structuring during recombination events and in eukaryotic organellar genome maintenance. However, beyond these well-studied roles, little is understood of the functional diversification of this large superfamily. Using sensitive sequence and structure analysis methods we identify multiple novel clades of the HU superfamily...
April 25, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28441028/application-of-gc-ms-soft-ionization-for-isomeric-biological-compound-analysis
#9
Takeshi Furuhashi, Koji Okuda
Isomers are compounds with the same molecular formula. Many different types of isomers are ubiquitous and play important roles in living organisms. Despite their early discovery, the actual analysis of isomers has been tricky and has confounded researchers. Using mass spectrometry (MS) to distinguish or identify isomers is an emergent topic and challenge for analytical chemists. We review some techniques for analyzing isomers with emphasis on MS, e.g., the roles of ion reaction, hydrogen-deuterium exchange, ion mobility mass spectrometry, ion spectroscopy and energy change in producing isomer-specific fragments...
April 25, 2017: Critical Reviews in Analytical Chemistry
https://www.readbyqxmd.com/read/28440506/association-between-high-mobility-group-box%C3%A2-1-protein-expression-and-cell-death-in-acute-pancreatitis
#10
Enjun Gao, Yanfeng Jiang, Zhituo Li, Dongbo Xue, Weihui Zhang
The present study used caerulein stimulation of AR42J rat pancreatic cells as an in vitro acute pancreatitis (AP) model to investigate proteins differentially expressed in apoptosis and necrosis. AR42J cells were stimulated with 10‑8mol/l caerulein and incubated for 24 h. Apoptosis and necrosis were detected using flow cytometry. The sorted Annexin V‑positive cells (apoptotic) and the Annexin V/propidium iodide double‑positive cells (necrotic) were analysed using proteomics. Results showed that numerous proteins were differentially expressed in these 2 groups...
April 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28439164/use-of-t-m-j-disc-as-a-soft-tissue-interpositional-graft-material-for-functional-rehabilitation-of-ankylosed-t-m-joint
#11
Ravinder Singh Bedi, Upasana Khemka, Jaipal Singh, Manoj Yadav, Pratibha Singh
INTRODUCTION: Many surgical techniques have been described for the treatment of TMJ ankylosis, but no strategy has been uniformly agreed upon underscoring the difficulty of the problem. Despite new guidelines and updated methods, treating patients with TMJ Ankylosis remains a challenge as the incidence of recurrence after treatment is soaring. This study exemplifies our experience in using an unsullied method to treat TMJ Ankylosis to restore the structure of TMJ in conjunction with convalescing secondary maxillofacial deformity...
June 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28438605/identifying-barriers-to-delivering-the-abcde-bundle-to-minimize-adverse-outcomes-for-mechanically-ventilated-patients-a-systematic-review
#12
Deena Kelly Costa, Matthew White, Emily Ginier, Milisa Manojlovich, Sushant Govindan, Theodore J Iwashyna, Anne E Sales
BACKGROUND: Improved outcomes are associated with the Awakening, Breathing Coordination, Delirium and Early mobility/exercise (ABCDE) bundle; however, implementation issues are common. As yet, no study has integrated the barriers to ABCDE to provide an overview of reasons for less successful efforts. The purpose of this review was to identify and catalog the barriers to ABCDE delivery based on a widely used implementation framework, and provide a resource to guide clinicians in overcoming barriers to implementation...
April 21, 2017: Chest
https://www.readbyqxmd.com/read/28437514/a-retrospective-study-on-possible-predictive-factors-for-long-term-temporomandibular-joint-degeneration-and-impaired-mobility-in-juvenile-arthritis-patients
#13
Stanimira I Kalaykova, Adriaan T Klitsie, Corine M Visscher, Machiel Naeije, Frank Lobbezoo
AIMS: To determine possible predictive factors for long-term temporomandibular joint (TMJ) degeneration and dysfunction in juvenile idiopathic arthritis (JIA) patients. METHODS: A total of 94 patients (77% female) who had received a JIA diagnosis in an outpatient rheumatology clinic from 1993 to 1994 at a mean ± standard deviation age of 8.3 ± 4.53 years were included in the study. At inclusion, TMJ status regarding condylar degeneration was assessed orthopantomographically and given a Rohlin and Petersson score of 0 or ≥ 1...
April 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28437353/evaluation-of-the-modern-luque-trolley-construct-for-the-treatment-of-early-onset-scoliosis-using-a-gliding-implant-in-an-immature-animal-model
#14
Jean A Ouellet, Catherine E Ferland, Karina Klein, Guillaume Racloz, Karina Klein, Henning Richter, Thomas Steffen, Brigitte von Rechenberg
STUDY DESIGN: This was an experimental animal study. OBJECTIVE: To determine biological compatibility, stability, and growth potential of the Trolley Gliding Vehicle (TGV) used in a novel surgical technique for guided spinal growth. SUMMARY OF BACKGROUND DATA: Current treatments for early-onset scoliosis maintaining spinal growth consist of posteriorly based spinal constructs requiring repetitive lengthening. Such interventions have a high rate of complications...
May 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28437334/a-new-fixation-technique-for-french-door-cervical-laminoplasty-surgical-results-with-a-minimum-follow-up-of-6-years
#15
Nanjundappa S Harshavardhana, Harshad V Dabke, Hossein Mehdian
DESIGN: A case series of 5 patients with multilevel cervical myelopathy treated by French-door cervical laminoplasty (FDCL) and use of unicortical iliac crest graft as spacer fixed with titanium miniplates and screws is described. OBJECTIVE: To report a minimum of 6-year follow-up results of our new plate-screw fixation technique for FDCL. SUMMARY OF BACKGROUND DATA: Hardware-assisted laminoplasty has the potential advantage of preventing restenosis by holding the laminar door "open" while healing progresses and also prevents spacer dislodgement...
May 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28436585/the-mobile-conjugate-reinforcement-paradigm-in-a-lab-setting
#16
Emily C Merz, Laraine McDonough, Yong Lin Huang, Sophie Foss, Elizabeth Werner, Catherine Monk
The mobile conjugate reinforcement task was administered to 4-month-old infants in a lab rather than a home setting where it is usually administered. Learning and retention patterns were comparable to those of infants tested in their homes, suggesting flexibility in where this task can be administered. These results pave the way for this task to be used with a broader range of infants for whom home visits are not practical or convenient (e.g., infants in child care). Developmental research conducted with a more diverse population of infants would facilitate our understanding of cognitive development very early in life...
April 24, 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/28436500/black-phosphorus-nanostructures-recent-advances-in-hybridization-doping-and-functionalization
#17
Wanying Lei, Gang Liu, Jin Zhang, Minghua Liu
Owing to its high charge-carrier mobility, tunable direct-bandgap and unique in-plane anisotropic structure, black phosphorus (BP), a rising star of post-graphene two-dimensional (2D) nanomaterials, has been intensively investigated since early 2014. To explore its full potential and push the limits, research into BP-based novel functional nanostructures (i.e., nanomaterials and nanodevices) by means of hybridization, doping, and functionalization is rapidly expanding. Indeed, the cutting-edge developments and applications of BP nanostructures have had a significant impact on a wide range of research areas, including field effect transistors, diodes, photodetectors, biomedicine, sodium-ion batteries, photocatalysis, electrocatalysis, memory devices, and more...
April 24, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28435128/randomized-trial-on-fast-track-care-in-colorectal-surgery-for-deep-infiltrating-endometriosis
#18
Marco Scioscia, Marcello Ceccaroni, Irene Gentile, Roberto Rossini, Roberto Clarizia, Davide Brunelli, Giacomo Ruffo
STUDY OBJECT: To study the application of a fast-track care protocol in colorectal surgery for deep infiltrating endometriosis. Bowel endometriosis is an infrequent but not rare condition that often needs intestinal surgery and imposes a high economic burden on society. DESIGN: Prospective randomized trial (Canadian Task Force I). SETTING: Tertiary referral center. PATIENTS: We randomly assigned 227 patients with preoperative evidence of bowel endometriosis to a fast-track (no preoperative bowel preparation, early restoration of diet, no postoperative antibiotics, and early post-operative mobilization) or conventional care for laparoscopic intestinal surgery...
April 18, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28432478/the-arabidopsis-splicing-factors-atu2af65-atu2af35-and-atsf1-shuttle-between-nuclei-and-cytoplasms
#19
Hyo-Young Park, Keh Chien Lee, Yun Hee Jang, Soon-Kap Kim, May Phyo Thu, Jeong Hwan Lee, Jeong-Kook Kim
The Arabidopsis splicing factors, AtU2AF65, AtU2AF35, and AtSF1 shuttle between nuclei and cytoplasms. These proteins also move rapidly and continuously in the nuclei, and their movements are affected by ATP depletion. The U2AF65 proteins are splicing factors that interact with SF1 and U2AF35 proteins to promote U2snRNP for the recognition of the pre-mRNA 3' splice site during early spliceosome assembly. We have determined the subcellular localization and movement of these proteins' Arabidopsis homologs. It was found that Arabidopsis U2AF65 homologs, AtU2AF65a, and AtU2AF65b proteins interact with AtU2AF35a and AtU2AF35b, which are Arabidopsis U2AF35 homologs...
April 21, 2017: Plant Cell Reports
https://www.readbyqxmd.com/read/28432419/-driving-and-dementia-an-issue-for-general-practice
#20
REVIEW
Verena Leve, Katharina Ilse, Marie Ufert, Stefan Wilm, Michael Pentzek
BACKGROUND: With most forms of dementia, the risk of road traffic accidents increases with disease progression. Addressing the issue of fitness to drive at an early stage can help to reduce driving-related risks and simultaneously preserve mobility. General practitioners (GPs) are central contact persons for dementia patients and their relatives in medical and psychosocial matters, and also play a key role in addressing the issue of driving safety. OBJECTIVE: Identification of relevant aspects of managing fitness to drive in dementia, as well as of support requirements for German general practice...
April 21, 2017: Zeitschrift Für Gerontologie und Geriatrie
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