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https://www.readbyqxmd.com/read/29777960/utility-of-cement-injection-to-stabilize-split-depression-tibial-plateau-fracture-by-minimally-invasive-methods-a-finite-element-analysis
#1
D Belaid, T Vendeuvre, A Bouchoucha, F Brémand, C Brèque, P Rigoard, A Germaneau
BACKGROUND: Treatment for fractures of the tibial plateau is in most cases carried out by stable fixation in order to allow early mobilization. Minimally invasive technologies such as tibioplasty or stabilization by locking plate, bone augmentation and cement filling (CF) have recently been used to treat this type of fracture. The aim of this paper was to determine the mechanical behavior of the tibial plateau by numerically modeling and by quantifying the mechanical effects on the tibia mechanical properties from injury healing...
May 8, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29777911/deficiency-in-gnrh-receptor-trafficking-due-to-a-novel-homozygous-mutation-causes-idiopathic-hypogonadotropic-hypogonadism-in-three-prepubertal-siblings
#2
Rui Zhang, Siyuan Linpeng, Zhuo Li, Yingxi Cao, Hu Tan, Desheng Liang, Lingqian Wu
Idiopathic hypogonadotropic hypogonadism (IHH) is characterized by low levels of gonadotropins and delayed or absent sexual development. Most of the patients are diagnosed in late adolescence or early adulthood. Determining the diagnosis of IHH in prepubertal patients can be challenging. Making a timely, correct diagnosis has important clinical implications. Here we aimed to identify the genetic cause of IHH in three prepubertal siblings from a Chinese Han family and give appropriate treatment advice. Using whole exome sequencing (WES), we identified a novel homozygous GNRHR mutation (NM_000406; c...
May 16, 2018: Gene
https://www.readbyqxmd.com/read/29777574/factors-influencing-the-umbilical-cord-blood-stem-cell-industry-an-evolving-treatment-landscape
#3
REVIEW
Carla Dessels, Marco Alessandrini, Michael Sean Pepper
Hematopoietic stem cell transplantation (HSCT) is common practice today for life threatening malignant and non-malignant diseases of the blood and immune systems. Umbilical cord blood (UCB) is rich in hematopoietic stem cells (HSCs) and is an attractive alternative to harvesting HSCs from bone marrow or when mobilized into peripheral blood. One of the most appealing attributes of UCB is that it can be banked for future use and hence provides an off-the-shelf solution for patients in urgent need of a transplantation...
May 18, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29776183/slowdown-of-surface-diffusion-during-early-stages-of-bacterial-colonization
#4
T Vourc'h, H Peerhossaini, J Léopoldès, A Méjean, F Chauvat, C Cassier-Chauvat
We study the surface diffusion of the model cyanobacterium Synechocystis sp. PCC6803 during the incipient stages of cell contact with a glass surface in the dilute regime. We observe a twitching motility with alternating immobile tumble and mobile run periods, resulting in a normal diffusion described by a continuous-time random walk with a coefficient of diffusion D. Surprisingly, D is found to decrease with time down to a plateau. This is observed only when the cyanobacterial cells are able to produce released extracellular polysaccharides, as shown by a comparative study between the wild-type strain and various polysaccharides-depleted mutants...
March 2018: Physical Review. E
https://www.readbyqxmd.com/read/29768407/the-health-e-babies-app-for-antenatal-education-feasibility-for-socially-disadvantaged-women
#5
Julia A Dalton, Dianne Rodger, Michael Wilmore, Sal Humphreys, Andrew Skuse, Claire T Roberts, Vicki L Clifton
BACKGROUND: The use of mobile technology such as phone applications (apps) has been proposed as an efficient means of providing health and clinical information in a variety of healthcare settings. We developed the Health-e Babies app as an Android smart phone application for pregnant women attending a tertiary hospital in a low socio-economic community, with the objective of providing health information about early pregnancy that would increase maternal confidence and reduce anxiety. Based on our earlier research, this form of health communication was viewed as a preferred source of information for women of reproductive age...
2018: PloS One
https://www.readbyqxmd.com/read/29767228/whiplash-injury-results-in-sustained-impairments-of-cervical-muscle-function-a-one-year-prospective-controlled-study
#6
Søren Krogh, Helge Kasch
OBJECTIVE: To investigate the temporal development of neck muscle function following whiplash injuries. DESIGN: A 1-year prospective, controlled observational study. SUBJECTS: A total of 141 individuals exposed to whiplash injury due to rear-end vehicle collisions and 40 age- and sex-matched controls with acute ankle distortion. METHODS: Neck muscle strength and endurance during cervical flexion and extension were measured at 1 week, 1 month, 3 months, 6 months and 1 year after injury...
May 16, 2018: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29767163/response-of-primiparous-and-multiparous-buffaloes-to-yeast-culture-supplementation-during-early-and-mid-lactation
#7
Hanne H Hansen, Nasr E El-Bordeny, Hossam M Ebeid
Strains of live Saccharomyces cerevisiae yeast have exhibited probiotic effects in ruminants. This study investigated the effects of the dietary yeast supplement, S . cerevisiae (Yea-Sacc1026 ), on primiparous (PP) and multiparous (MP) Egyptian buffaloes in early to mid-lactation. Lactating buffaloes were fed either a basal total mixed ration (TMR, control; 4 PP and 8 MP) or the basal TMR plus 10 g Yea-Sacc1026 per buffalo cow per day (yeast; 4 PP and 8 MP). The feeds were given from 15 days prepartum to 180 days postpartum...
December 2017: Animal nutrition
https://www.readbyqxmd.com/read/29767079/gluconeogenesis-during-starvation-and-refeeding-phase-is-affected-by-previous-dietary-carbohydrates-levels-and-a-glucose-stimuli-during-early-life-in-siberian-sturgeon-acipenser-baerii
#8
Xiaofang Liang, Jia Wang, Guan Gong, Min Xue, Yingchao Dong, Xiufeng Wu, Xin Wang, Chunshan Chen, Xufang Liang, Yuchang Qin
Gluconeogenesis responses was assessed during a short starvation period and subsequent refeeding in Siberian sturgeon ( Acipenser baerii ) previously fed different dietary carbohydrates levels and experienced to a glucose stimuli during early life. The sturgeon larvae were previously fed either a high glucose diet (G) or a low glucose diet (F) from the first feeding to yolk absorption (8 to 12 d post-hatching [dph]). Each group of fish was sub-divided into 2 treatments at 13 dph and was fed either a high-carbohydrate diet (H) or a low carbohydrate diet (L) until 20 wk...
September 2017: Animal nutrition
https://www.readbyqxmd.com/read/29765882/relationship-between-functional-level-and-muscle-thickness-in-young-children-with-cerebral-palsy
#9
Yeo Reum Choe, Joo Sup Kim, Kee Hoon Kim, Tae Im Yi
Objective: To investigate the relationship between functional level and muscle thickness (MT) of the rectus femoris (RF) and the gastrocnemius (GCM) in young children with cerebral palsy (CP). Methods: The study participants were comprised of 26 children (50 legs) with spastic CP, aged 3-6 years, and 25 age-matched children with typical development (TD, 50 legs). The MT of the RF, medial GCM, and lateral GCM was measured with ultrasound imaging. The functional level was evaluated using the Gross Motor Function Measurement-88 (GMFM-88), Gross Motor Function Classification System (GMFCS), and based on the mobility area of the Korean version of the Modified Barthel Index (K-MBI)...
April 2018: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29765684/clawed-forelimbs-allow-northern-seals-to-eat-like-their-ancient-ancestors
#10
David P Hocking, Felix G Marx, Renae Sattler, Robert N Harris, Tahlia I Pollock, Karina J Sorrell, Erich M G Fitzgerald, Matthew R McCurry, Alistair R Evans
Streamlined flippers are often considered the defining feature of seals and sea lions, whose very name 'pinniped' comes from the Latin pinna and pedis , meaning 'fin-footed'. Yet not all pinniped limbs are alike. Whereas otariids (fur seals and sea lions) possess stiff streamlined forelimb flippers, phocine seals (northern true seals) have retained a webbed yet mobile paw bearing sharp claws. Here, we show that captive and wild phocines routinely use these claws to secure prey during processing, enabling seals to tear large fish by stretching them between their teeth and forelimbs...
April 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29762928/early-thrombosis-of-a-mitral-annuloplasty-ring-in-a-patient-with-mthfr-and-factor-v-leiden-mutations
#11
Sinan Cerşit, Emrah Bayam, Sabahattin Gündüz, Mehmet Özkan
Mitral annuloplasty ring thrombosis is an extremely infrequent pathology, for which no evidence-based antithrombotic management has yet been described. Herein is presented a case of heterozygous Factor V Leiden (FVL) and hyperhomocysteinemia with homozygous methylenetetrahydrofolate reductase (MTHFR) mutations that caused early thrombosis of the mitral annuloplasty ring. The clinical management and antithrombotic treatment of the patient, and the implications of hyperhomocysteinemia, are discussed. Video 1: Mobile 9-mm thrombus of mitral annuloplasty ring on two-dimensional (2D) transesophageal echocardiography...
September 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/29762741/a-longitudinal-analysis-of-the-intergenerational-transmission-of-health-inequality
#12
Andrea E Willson, Kim M Shuey
Objectives: Empirical investigations of cumulative dis/advantage typically treat health inequality as an intra-individual process rooted in early-life conditions and operating within the span of the individual life course, while literature on processes of intergenerational transmission has historically focused on socioeconomic mobility, largely overlooking health. The current study examines the persistence of work disability across generations and multiple explanations for this relationship, including the role of early life disadvantage, childhood health, educational attainment, and social mobility...
May 14, 2018: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/29760052/spatial-mutation-patterns-as-markers-of-early-colorectal-tumor-cell-mobility
#13
Marc D Ryser, Byung-Hoon Min, Kimberly D Siegmund, Darryl Shibata
A growing body of evidence suggests that a subset of human cancers grows as single clonal expansions. In such a nearly neutral evolution scenario, it is possible to infer the early ancestral tree of a full-grown tumor. We hypothesized that early tree reconstruction can provide insights into the mobility phenotypes of tumor cells during their first few cell divisions. We explored this hypothesis by means of a computational multiscale model of tumor expansion incorporating the glandular structure of colorectal tumors...
May 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29757410/chronic-kidney-disease-and-peripheral-nerve-function-in-the-health-aging-and-body-composition-study
#14
Ranjani N Moorthi, Simit Doshi, Linda F Fried, Sharon M Moe, Mark J Sarnak, Suzanne Satterfield, Ann V Schwartz, Michael Shlipak, Brittney S Lange-Maia, Tamara B Harris, Anne B Newman, Elsa S Strotmeyer
Background: Chronic kidney disease (CKD) is associated with poor mobility. Peripheral nerve function alterations play a significant role in low mobility. We tested the hypothesis that early CKD is associated with altered sensory, motor and autonomic nerve function. Methods: Participants in the Health, Aging and Body Composition cohort who had kidney function measures in Year 3 (1999-2000) and nerve function measurements at Year 4 (2000-01) were analyzed (n = 2290)...
May 10, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29756363/treatment-for-t3-to-t4a-laryngeal-cancer-by-open-partial-horizontal-laryngectomies-prognostic-impact-of-different-pathologic-tumor-subcategories
#15
Giovanni Succo, Erika Crosetti, Andy Bertolin, Cesare Piazza, Gabriele Molteni, Stefano Cirillo, Massimo Petracchini, Martina Tascone, Andrea Elio Sprio, Giovanni Nicolao Berta, Giorgio Peretti, Livio Presutti, Giuseppe Rizzotto
BACKGROUND: The purpose of this retrospective study was to identify subcategories in cT3 to cT4a supraglottic/glottic cancers, describing their different spreading patterns, and local and locoregional recurrence modes. METHODS: Four hundred eighty-nine patients who underwent open partial horizontal laryngectomies (OPHLs) were retrospectively classified as: subcategory I (anterior pT3 with normal arytenoid mobility); subcategory II (posterior pT3 with impaired/absent mobility); subcategory III (anterior pT4 with normal mobility); and subcategory IV (posterior pT4 with impaired/absent mobility)...
May 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29755713/a-mobile-multimedia-reminiscence-therapy-application-to-reduce-behavioral-and-psychological-symptoms-in-persons-with-alzheimer-s
#16
Danish Imtiaz, Arshia Khan, Adriana Seelye
The goal of this project is to develop a novel and innovative mobile solution to address behavioral and psychological symptoms of dementia (BPSD) that occur in individuals with Alzheimer's. BPSD can include agitation, restlessness, aggression, apathy, obsessive-compulsive and repetitive behaviors, hallucinations, delusions, paranoia, and wandering. Alzheimer's currently affects 5.4 million adults in the United States and that number is projected to increase to 14 million by 2050. Almost 90% of all affected with AD experience BPSD, resulting in increased healthcare costs, heavier burden on caregivers, poor patient outcomes, early nursing home placement, long-term hospitalizations, and misuse of medications...
2018: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29755241/preoperative-manual-on-table-traction-for-the-reduction-of-thoracolumbar-burst-fractures-a-technical-note
#17
Petrini Carlo, Cacciola Francesco
Thoracolumbar burst fractures can frequently be treated either conservatively or surgically. Surgery is generally preferred when safe early mobilization with a reconstructed sagittal alignment is wanted without any external restraint. Various dedicated instruments are available on the market to perform reduction and distraction maneuvers on the spine intraoperatively to restore normal sagittal alignment after a fracture. The authors describe a simple but effective technique of proper patient positioning and preoperative on-table-traction that can effectively aid in the restoration of alignment and performance of surgery even with the most basic instrumentation...
January 2018: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/29753890/characterization-of-the-promoter-of-white-spot-syndrome-virus-immediate-early-gene-wsv249
#18
Zi Yang, Xiaomin Xu, Fang Li, Feng Yang
White spot syndrome virus immediate early (IE) gene wsv249 encodes an E3 ubiquitin ligase that can interact with a shrimp ubiquitin-conjugating enzyme to mediate ubiquitination. In this study, to understand the transcriptional regulation of wsv249, a serial of 5'-truncated mutations were made on its promoter and the activities of mutated promoters was analyzed. Four 25 bp regions potentially containing either positive or negative regulatory elements were identified. Notably, the deletion of -275/-250, which abolished a cAMP-response element (CRE), greatly reduced the promoter activity by 84...
May 10, 2018: Virus Research
https://www.readbyqxmd.com/read/29753677/multicenter-phase-1-2-application-of-adenovirus-specific-t-cells-in-high-risk-pediatric-patients-after-allogeneic-stem-cell-transplantation
#19
Winnie Ip, Juliana M F Silva, Hubert Gaspar, Arindam Mitra, Shreenal Patel, Kanchan Rao, Robert Chiesa, Persis Amrolia, Kimberly Gilmour, Gul Ahsan, Mary Slatter, Andrew R Gennery, Robert F Wynn, Paul Veys, Waseem Qasim
BACKGROUND: Adenovirus (ADV) reactivation can cause significant morbidity and mortality in children after allogeneic stem cell transplantation. Antiviral drugs can control viremia, but viral clearance requires recovery of cell-mediated immunity. METHOD: This study was an open-label phase 1/2 study to investigate the feasibility of generating donor-derived ADV-specific T cells (Cytovir ADV, Cell Medica) and to assess the safety of pre-emptive administration of ADV-specific T cells in high-risk pediatric patients after allogeneic hematopoietic stem cell transplantation (HSCT) to treat adenoviremia...
May 9, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29753346/clinical-outcome-assessments-use-of-normative-data-in-a-pediatric-rare-disease
#20
Dawn Phillips, Beth Leiro
Pediatric rare diseases present unique challenges in clinical trial design and in selection of clinical outcome assessments (COAs) used to support claims in medical product labeling. COAs that discriminate level of function relative to a normative sample are particularly important in the pediatric rare disease setting because the literature is often void of natural history data. Pediatric rare disease clinical trials will often include a wide age distribution. Gross and fine motor skills, communication, cognition, and independence in activities of daily living vary by age, and it may be difficult to distinguish between treatment effect and change due to developmental maturation...
May 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
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