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https://www.readbyqxmd.com/read/29684297/is-medical-marijuana-legalisation-possible-in-poland
#1
Dorota Rogowska-Szadkowska, Julia Strumiło, Sławomir Chlabicz
OBJECTIVES: In some countries of the world it is legal to use plant-based marijuana for therapeutic purposes. When we had learned that 7,000 petitioners (including doctors) signed the petition to enable access to marijuana for patients in the Czech Republic, we decided to examine the knowledge about marijuana's medical properties among Polish medical students. METHODS: Anonymous questionnaire study was conducted on a group of 181 of students of the last (sixth) year of medical school...
March 2018: Central European Journal of Public Health
https://www.readbyqxmd.com/read/29560966/medical-cannabis-in-the-treatment-of-cancer-pain-and-spastic-conditions-and-options-of-drug-delivery-in-clinical-practice
#2
Leos Landa, Jan Jurica, Jiri Sliva, Monika Pechackova, Regina Demlova
The use of cannabis for medical purposes has been recently legalised in many countries including the Czech Republic. As a result, there is increased interest on the part of physicians and patients in many aspects of its application. This mini review briefly covers the main active substances of the cannabis plant and mechanisms of action. It focuses on two conditions, cancer pain and spasticity in multiple sclerosis, where its effects are well-documented. A comprehensive overview of a few cannabis-based products and the basic pharmacokinetics of marijuana's constituents follows...
March 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29512125/evaluation-of-marijuana-compounds-on-neuroimmune-endpoints-in-experimental-autoimmune-encephalomyelitis
#3
Barbara L F Kaplan
Cannabinoid compounds refer to a group of more than 60 plant-derived compounds in Cannabis sativa, more commonly known as marijuana. Exposure to marijuana and cannabinoid compounds has been increasing due to increased societal acceptance for both recreational and possible medical use. Cannabinoid compounds suppress immune function, and while this could compromise one's ability to fight infections, immune suppression is the desired effect for therapies for autoimmune diseases. It is critical, therefore, to understand the effects and mechanisms by which cannabinoid compounds alter immune function, especially immune responses induced in autoimmune disease...
February 21, 2018: Current Protocols in Toxicology
https://www.readbyqxmd.com/read/29396837/examining-burnout-depression-and-attitudes-regarding-drug-use-among-lebanese-medical-students-during-the-4%C3%A2-years-of-medical-school
#4
Farid Talih, Michel Daher, Dayane Daou, Jean Ajaltouni
OBJECTIVES: This study aims to evaluate the prevalence of burnout, depressive symptoms, and anxiety symptoms and attitudes toward substance use in medical students as well as their evolution during the 4 years of medical school. METHODS: A cross-sectional study was carried out at the American University of Beirut Medical Center (AUBMC) between September and December 2016. In total, 176 out of 412 eligible medical students responded. The survey was anonymous and administered via e-mail link to an electronic form...
February 2, 2018: Academic Psychiatry
https://www.readbyqxmd.com/read/29340893/a-prospective-study-of-humoral-and-cellular-immune-responses-to-hepatitis-b-vaccination-in-habitual-marijuana-smokers
#5
Sylvia M Kiertscher, Pallavi R Gangalum, Grace Ibrahim, Donald P Tashkin, Michael D Roth
Exposure to Δ9-tetrahydrocannabinol (THC) in vitro and in animal models can significantly impair the differentiation, activation and function of dendritic cells, T cells and B cells. However, studies directly assessing the impact of marijuana smoking on human immunity are lacking. A prospective study of immune responses to a standard hepatitis B vaccination was therefore carried out in a matched cohort of 9 marijuana smokers (MS) and 9 nonsmokers (NS). In addition to their regular marijuana use, MS smoked four marijuana cigarettes in a monitored setting on the day of each vaccination...
January 16, 2018: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/29273844/attitudes-perceptions-and-use-of-marijuana-in-youth-with-multiple-sclerosis
#6
J Nicholas Brenton, Teri Schreiner, Krystle Karoscik, Meg Richter, Samantha Ferrante, Amy Waldman, Brenda Banwell
BACKGROUND: Studies have shown a negative impact on cognition and brain volume in marijuana-using adult multiple sclerosis (MS) patients and healthy adolescents. Given that onset of MS during childhood and adolescence negatively impacts brain growth and the normal maturation of neuronal networks, the addition of marijuana exposure in these youth may be even more harmful. OBJECTIVE: Determine attitudes toward and prevalence of recreational marijuana use in MS youth...
February 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29185555/perspectives-on-marijuana-use-and-effectiveness-a-survey-of-narcoms-participants
#7
Stacey S Cofield, Amber Salter, Tuula Tyry, Christina Crowe, Gary R Cutter, Robert J Fox, Ruth Ann Marrie
Background: Interest in and use of marijuana by persons with multiple sclerosis (MS) has increased. While potential benefits have been reported, so have concerns about potential risks. Few large studies have been conducted about the perceptions and current usage of marijuana and medical cannabinoids in persons with MS. Methods: Participants in the North American Research Committee on Multiple Sclerosis (NARCOMS) registry were surveyed in 2014 regarding legality and history of marijuana usage, both before and after diagnosis with MS...
August 2017: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/29183315/prevalence-of-poor-mental-health-among-medical-students-in-nepal-a-cross-sectional-study
#8
Arjab Adhikari, Aman Dutta, Supriya Sapkota, Abina Chapagain, Anurag Aryal, Amita Pradhan
BACKGROUND: Poor mental health among medical students is widely acknowledged. Studies on mental health among medical students of Nepal are lacking. Therefore, we conducted a study to determine the prevalence of mental disorders. METHODS: A cross-sectional study was conducted among medical students at KIST Medical College and Teaching Hospital, Nepal from December 2016 to February 2017. Our survey instrument consisted of the Patient Health Questionnaire (PHQ) and questions about socio-demographic factors, smoking, marijuana use, suicidal ideation and thoughts of dropping out of medical school...
November 28, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29176975/targeting-cannabinoid-signaling-in-the-immune-system-high-ly-exciting-questions-possibilities-and-challenges
#9
REVIEW
Attila Oláh, Zoltán Szekanecz, Tamás Bíró
It is well known that certain active ingredients of the plants of Cannabis genus, i.e., the "phytocannabinoids" [pCBs; e.g., (-)- trans -Δ9 -tetrahydrocannabinol (THC), (-)-cannabidiol, etc.] can influence a wide array of biological processes, and the human body is able to produce endogenous analogs of these substances ["endocannabinoids" (eCB), e.g., arachidonoylethanolamine (anandamide, AEA), 2-arachidonoylglycerol (2-AG), etc.]. These ligands, together with multiple receptors (e.g., CB1 and CB2 cannabinoid receptors, etc...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29108735/emergency-department-patient-burden-from-an-electronic-dance-music-festival
#10
Neeraj Chhabra, Renee P Gimbar, Lisa M Walla, Trevonne M Thompson
BACKGROUND: Electronic dance music (EDM) festivals are increasingly common and psychoactive substance use is prevalent. Although prehospital care can obviate the transfer of many attendees to health care facilities (HCFs), little is known regarding the emergency department (ED) burden of patients presenting from EDM festivals. OBJECTIVES: This study describes the patient volume, length of stay (LOS), and presenting complaints of patients from a 3-day EDM festival in close proximity to an area ED...
November 3, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29072119/prevalence-perceptions-and-consequences-of-substance-use-in-medical-students
#11
Erin E Ayala, Destiny Roseman, Jeffrey S Winseman, Hyacinth R C Mason
BACKGROUND: Research regarding the health and wellness of medical students has led to ongoing concerns regarding patterns of alcohol and drug use that take place during medical education. Such research, however, is typically limited to single-institution studies or has been conducted over 25 years ago. OBJECTIVE: The objective of the investigation was to assess the prevalence and consequences of medical student alcohol and drug use and students' perceptions of their medical school's substance-use policies...
2017: Medical Education Online
https://www.readbyqxmd.com/read/29037744/intoxication-from-the-novel-synthetic-cannabinoids-ab-pinaca-and-adb-pinaca-a-case-series-and-review-of-the-literature
#12
REVIEW
Patil Armenian, Michael Darracq, Jirair Gevorkyan, Shane Clark, Bryan Kaye, Nicklaus P Brandehoff
Synthetic cannabinoids (SC), are a novel class of designer drugs which emerged as a drug of abuse in the late 2000's. We report a case series of 6 patients who may have smoked a synthetic cannabinoid product in a remote wilderness setting. They presented with varying degrees of altered mental status, agitation, and seizures. Two were confirmed to have AB-PINACA, ADB-PINACA and their respective pentanoic acid metabolites in biological specimens via liquid chromatography time-of-flight mass spectrometry (LC-TOF/MS)...
October 14, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28987305/unintentional-marijuana-exposure-presenting-as-altered-mental-status-in-the-pediatric-emergency-department-a-case-series
#13
Anita A Thomas, Suzan Mazor
BACKGROUND: Unintentional tetrahydrocannabinol (THC) exposure in pediatric patients can present as altered mental status. Altered mental status in a pediatric patient often leads to invasive diagnostic testing. CASE REPORT: The following cases describe 3 pediatric patients in Washington state who presented to a tertiary care children's hospital emergency department (ED) with altered mental status, later found to have urine toxicology screening positive for inactive THC metabolite (positive THC toxicology screen)...
December 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28977394/development-of-a-liquid-chromatography-tandem-mass-spectrometry-method-for-the-simultaneous-determination-of-four-cannabinoids-in-umbilical-cord-tissue
#14
Fang Wu, Triniti L Scroggin, Torri D Metz, Gwendolyn A McMillin
In utero exposure to marijuana may cause various short- and long-term health problems, such as stillbirth, low birth weight and decreased cognitive function. Detection of in utero marijuana exposure with a relatively new specimen type, umbilical cord tissue, can be used to plan treatment and guide social management. In this study, a liquid chromatography-tandem mass spectrometry (LC-MS-MS) assay was developed for the simultaneous identification of four cannabinoids in umbilical cord tissue, including ∆9-tetrahydrocannabinol (THC), 11-nor-9-carboxy-∆9--THC (THC-COOH), 11-hydroxy-∆9-THC (11-OH-THC) and cannabinol (CBN)...
January 1, 2018: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28948698/detection-of-in-utero-cannabis-exposure-by-umbilical-cord-analysis
#15
Jiyoung Kim, Ana de Castro, Elena Lendoiro, Angelines Cruz-Landeira, Manuel López-Rivadulla, Marta Concheiro
According to 2014 National Survey on Drug Use and Health, 5.3% of pregnant women smoked marijuana in the past month. This prevalence is expected to increase as a growing number of states and countries are now considering legalization. Although umbilical cord is becoming a useful objective tool to detect in utero drug exposure, currently data about analytical methods and its utility to detect cannabis exposure are scarce. The objective of this work was to develop a method for the determination of Δ(9) -tetrahydrocannabinol (THC), 11-hydroxyTHC (THC-OH), 11-nor-9-carboxy-THC (THCCOOH), 8-β-11-dihydroxyTHC (THC-diOH), THC and THCCOOH glucuronides, and cannabidiol (CBD) in umbilical cord by liquid chromatography-tandem mass spectrometry (LC-MS-MS) with dual ionization source...
September 25, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28832279/gender-differences-in-substance-use-and-psychiatric-distress-among-medical-students-a-comprehensive-statewide-evaluation
#16
Lisa J Merlo, John S Curran, Robert Watson
BACKGROUND: Medical student wellness has emerged as an important issue in medical education. The purpose of the present study was to obtain a comprehensive assessment of substance use, psychological distress, and help-seeking among male and female medical students in order to identify targets for continued intervention efforts. METHODS: Medical students from all 9 medical schools in the state of Florida were invited via e-mail and/or announcements to complete an anonymous online questionnaire assessing their well-being...
August 23, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28725842/understanding-patients-process-to-use-medical-marijuana-a-southern-new-jersey-community-engagement-project
#17
Tara L Crowell
Given the necessity to better understand the process patients need to go through in order to seek treatment via medical marijuana, this study investigates this process to better understand this phenomenon. Specifically, Compassion Care Foundation (CCF) and Stockton University worked together to identify a solution to this problem. Specifically, 240 new patients at CCF were asked to complete a 1-page survey regarding various aspects associated with their experience prior to their use of medicinal marijuana-diagnosis, what prompted them to seek treatment, level of satisfaction with specific stages in the process, total length of time the process took, and patient's level of pain...
September 2016: Journal of patient experience
https://www.readbyqxmd.com/read/28668480/a-new-challenge-in-forensic-toxicology-exemplified-by-a-case-of-murder-under-the-influence-of-a-synthetic-cannabinoid-am-2201
#18
Sebastian Rojek, Małgorzata Kłys, Martyna Maciów-Głąb, Karol Kula
Among new psychoactive substances (NPS) available on the narcotic market, a significant number consists of synthetic cannabinoids commonly known as smokable herbal "spice" and "K2", and which are legally treated as a legal alternative to marijuana. The dearth of information on the pharmacology of these intoxicants as they are introduced into the market has created the urgent need among healthcare providers for case studies on the substances belonging to this group, both in terms of the consequences of using such intoxicants, and in methods of detection...
June 24, 2017: Legal Medicine
https://www.readbyqxmd.com/read/28640062/an-atmospheric-pressure-chemical-ionization-ms-ms-assay-using-online-extraction-for-the-analysis-of-11-cannabinoids-and-metabolites-in-human-plasma-and-urine
#19
Jelena Klawitter, Cristina Sempio, Sophie Mörlein, Erik De Bloois, Jacek Klepacki, Thomas Henthorn, Maureen A Leehey, Edward J Hoffenberg, Kelly Knupp, George S Wang, Christian Hopfer, Greg Kinney, Russell Bowler, Nicholas Foreman, Jeffrey Galinkin, Uwe Christians, Jost Klawitter
BACKGROUND: Although, especially in the United States, there has been a recent surge of legalized cannabis for either recreational or medicinal purposes, surprisingly little is known about clinical dose-response relationships, pharmacodynamic and toxicodynamic effects of cannabinoids such as Δ9-tetrahydrocannabinol (THC). Even less is known about other active cannabinoids. METHODS: To address this knowledge gap, an online extraction, high-performance liquid chromatography coupled with tandem mass spectrometry method for simultaneous quantification of 11 cannabinoids and metabolites including THC, 11-hydroxy-Δ9-tetrahydrocannabinol, 11-nor-Δ9-tetrahydrocannabinol-9-carboxylic acid, 11-nor-Δ9-tetrahydrocannabinol-9-carboxylic acid glucuronide (THC-C-gluc), cannabinol, cannabidiol, cannabigerol, cannabidivarin, Δ9-tetrahydrocannabivarin (THCV), and 11-nor-9-carboxy-Δ9-tetrahydrocannabivarin (THCV-COOH) was developed and validated in human urine and plasma...
October 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28622813/evaluation-of-drug-use-and-medication-compliance-in-adolescents-admitted-to-a-psychiatric-facility-from-the-pediatric-emergency-department
#20
George Sam Wang, Genie Roosevelt, Amy Becker, Lina Brou, Jeffrey L Galinkin
OBJECTIVES: Knowledge of drug use and medication compliance during mental health evaluation can help guide evaluation and treatment. The objective was to evaluate drug use and medication compliance in a pediatric emergency department (PED) psychiatric population by comparing medical history, standard urine drug screen (EIA), and expanded urine drug screen (HPLC-MS/MS). METHODS: A prospective cohort study of admitted psychiatric patients ≥13years and ≤18years in a tertiary-care children's hospital psychiatric ED from January 31, 2013 through April 16, 2014...
May 2017: General Hospital Psychiatry
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