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https://www.readbyqxmd.com/read/27911435/detecting-biomarkers-of-secondhand-marijuana-smoke-in-young-children
#1
Karen M Wilson, Michelle R Torok, Binnian Wei, Lanqing Wang, Michelle Robinson, Connie S Sosnoff, Benjamin C Blount
BACKGROUND: The impact of secondhand marijuana smoke exposure on children is unknown. New methods allow detection of secondhand marijuana smoke in children. METHODS: We studied children ages 1 month to 2 years hospitalized with bronchiolitis in Colorado from 2013-2015. Parents completed a survey, and urine samples were analyzed for cotinine using LC/MS/MS (LOD 0.03 ng/ml) and marijuana metabolites including COOH-THC (LOD 0.015 ng/ml). RESULTS: A total of 43 subjects had urine samples available for analysis...
December 2, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27829351/recent-updates-in-imperative-natural-compounds-for-healthy-brain-and-nerve-function-a-systematic-review-of-implications-for-multiple-sclerosis
#2
Nima Sanadgol, Shahram Shahraki Zahedani, Mohammad Sharifzadeh, Roghayeh Khalseh, Gullam Reza Barbari, Mohammad Abdollahi
BACKGROUND: The evolution of the 'Green' movement in western society has changed attitudes in the general population who now perceive natural compounds as being inherently harmless and more desirable than artificial chemical products. OBJECTIVE: Considering the growing interest towards introducing naturally emerged medicines, the purpose of this review was to overview the ongoing research into prevention and treatment of multiple sclerosis (MS) lesions. METHOD: This review was carried out by searching bibliographic databases such as PubMed and Scopus for studies reported between 1th January 2008 to 30rd January 2016 on MS patients or animal models of MS, investigating the beneficial effects of natural compounds in MS treatment...
November 8, 2016: Current Drug Targets
https://www.readbyqxmd.com/read/27815614/cannabinoids-assessment-in-plasma-and-urine-by-high-performance-liquid-chromatography-tandem-mass-spectrometry-after-molecularly-imprinted-polymer-microsolid-phase-extraction
#3
Juan Sánchez-González, Rocío Salgueiro-Fernández, Pamela Cabarcos, Ana María Bermejo, Pilar Bermejo-Barrera, Antonio Moreda-Piñeiro
A molecularly imprinted polymer (MIP) selective for cannabinoids [Δ(9)-tetrahydrocannabinol (Δ9-THC), 11-nor-9-carboxy-Δ(9)-tetrahydrocannabinol (Δ9-THC-COOH), and 11-hydroxy-Δ(9)-tetrahydrocannabinol (Δ9-THC-OH)] has been synthesized, fully characterized, and applied to the assessment of plasma and urine analysis of marijuana abuse by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Δ9-THC-COOH was used as a template molecule, whereas ethylene glycol dimethacrylate (EGDMA) was used as a functional monomer, divinylbenzene (DVB) as a cross-linker, and 2,2'-azobisisobutyronitrile (AIBN) as an initiator...
November 4, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27789118/adverse-structural-and-functional-effects-of-marijuana-on-the-brain-evidence-reviewed
#4
REVIEW
David E Mandelbaum, Suzanne M de la Monte
The growing use and legalization of cannabis are leading to increased exposures across all age groups, including in adolescence. The touting of its medicinal values stems from anecdotal reports related to treatment of a broad range of illnesses including epilepsy, multiple sclerosis, muscle spasms, arthritis, obesity, cancer, Alzheimer disease, Parkinson disease, post-traumatic stress, inflammatory bowel disease, and anxiety. However, it is essential that anecdotal data and the high level of interest in this treatment not obscure objective assessments of any potential and realized short- and long-term adverse effects of cannabis, particularly with respect to age of onset and chronicity of exposure...
September 13, 2016: Pediatric Neurology
https://www.readbyqxmd.com/read/27780499/when-the-grass-isn-t-greener-a-case-series-of-young-children-with-accidental-marijuana-ingestion
#5
Derek Murray, Joshua Olson, Ana Sofia Lopez
Marijuana is the most commonly used illicit drug in Canada, with 10% of the general population admitting to its use in the past year. This high prevalence increases risk of accidental ingestion in young children. We report four pediatric cases of accidental marijuana ingestion who presented to our local emergency department with altered mental status. Three patients had extensive testing, including one patient who underwent lumbar puncture and empirical treatment for meningitis. To our knowledge, this is the first Canadian case series since McNabb et al...
November 2016: CJEM
https://www.readbyqxmd.com/read/27757048/medical-cannabis-the-canadian-perspective
#6
Gordon D Ko, Sara L Bober, Sean Mindra, Jason M Moreau
Cannabis has been widely used as a medicinal agent in Eastern medicine with earliest evidence in ancient Chinese practice dating back to 2700 BC. Over time, the use of medical cannabis has been increasingly adopted by Western medicine and is thus a rapidly emerging field that all pain physicians need to be aware of. Several randomized controlled trials have shown a significant and dose-dependent relationship between neuropathic pain relief and tetrahydrocannabinol - the principal psychoactive component of cannabis...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27681343/a-fast-and-comprehensive-analysis-of-32-synthetic-cannabinoids-using-agilent-triple-quadrupole-lc-ms-ms
#7
Damon Borg, Anna Tverdovsky, Richard Stripp
Synthetic cannabinoids are a group of psychoactive compounds that mimic the effects of Δ9-tetrahydrocannabinol, the primary psychoactive constituent of marijuana (Cannabis sativa L). The Drug Enforcement Administration has classified many of the most common cannabinoids as Schedule 1 controlled substances. As a result, several novel synthetic cannabinoid series have emerged in the illicit drug market, including PINACA, FUBINACA, PB-22, AKB-48 and multiple derivatives of these compounds. Our laboratory developed and validated an analytical method for the analysis 32 synthetic cannabinoid metabolites in urine samples...
September 27, 2016: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/27428345/-cannabis-effects-in-the-central-nervous-system-therapeutic-societal-and-legal-consequences
#8
Víctor Manuel Rivera-Olmos, Marisela C Parra-Bernal
The consumption of marijuana extracted from Cannabis sativa and indica plants involves an important cultural impact in Mexico. Their psychological stimulatory effect is widely recognized; their biochemical and molecular components interact with CB1 and CB2 (endocannabinoid system) receptors in various central nervous system structures (CNS) and immune cells. The psychoactive element Δ-9-tetrahydrocannabinol (THC) can be reproduced synthetically. Systematic reviews show evidence of therapeutic effectiveness of therapeutic marijuana only for certain symptoms of multiple sclerosis (spasticity, spasms and pain), despite attempts for its widespread use, including refractory childhood epilepsy...
September 2016: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/27339479/fatal-intoxication-involving-3-meo-pcp-a-case-report-and-validated-method
#9
Erica Bakota, Crystal Arndt, Amelia A Romoser, Stephen K Wilson
We present in this case report a validated method for accurate quantitative analysis of 3-methoxy phencyclidine (3-MeO-PCP) to determine postmortem blood concentrations of this PCP analog. A 29-year-old male with a history of illicit drug use was found unresponsive in his bed with a bag of white powder next to him. Resuscitation efforts were unsuccessful and the individual was pronounced dead 9 minutes after arrival to the hospital. Initial ELISA screening suggested the presence of PCP in the decedent's blood...
September 2016: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/27255136/clinical-effects-of-synthetic-cannabinoid-receptor-agonists-compared-with-marijuana-in-emergency-department-patients-with-acute-drug-overdose
#10
Milana Zaurova, Robert S Hoffman, David Vlahov, Alex F Manini
INTRODUCTION: Synthetic cannabinoid receptor agonists (SCRAs) are heterogeneous compounds originally intended as probes of the endogenous cannabinoid system or as potential therapeutic agents. We assessed the clinical toxicity associated with recent SCRA use in a large cohort of drug overdose patients. METHODS: This subgroup analysis of a large (n = 3739) drug overdose cohort study involved consecutive ED patients at two urban teaching hospitals collected between 2009 and 2013...
December 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/27108324/in-vitro-propagation-of-cannabis-sativa-l-and-evaluation-of-regenerated-plants-for-genetic-fidelity-and-cannabinoids-content-for-quality-assurance
#11
Hemant Lata, Suman Chandra, Ikhlas A Khan, Mahmoud A ElSohly
Cannabis sativa L. (Marijuana; Cannabaceae), one of the oldest medicinal plants in the world, has been used throughout history for fiber, food, as well as for its psychoactive properties. The dioecious and allogamous nature of C. sativa is the major constraint to maintain the consistency in chemical profile and overall efficacy if grown from seed. Therefore, the present optimized in vitro propagation protocol of the selected elite germplasm via direct organogenesis and quality assurance protocols using genetic and chemical profiling provide an ideal pathway for ensuring the efficacy of micropropagated Cannabis sativa germplasm...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27086601/endocannabinoid-system-a-multi-facet-therapeutic-target
#12
REVIEW
Rimplejeet Kaur, Sneha R Ambwani, Surjit Singh
Cannabis sativa is also popularly known as marijuana. It has been cultivated and used by man for recreational and medicinal purposes since many centuries. Study of cannabinoids was at bay for very long time and its therapeutic value could not be adequately harnessed due to its legal status as proscribed drug in most of the countries. The research of drugs acting on endocannabinoid system has seen many ups and downs in the recent past. Presently, it is known that endocannabinoids has role in pathology of many disorders and they also serve "protective role" in many medical conditions...
2016: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/27059691/analysis-of-a-commercial-marijuana-e-cigarette-formulation
#13
Michelle R Peace, Joseph W Stone, Justin L Poklis, Joseph B M Turner, Alphonse Poklis
Personal battery-powered vaporizers or electronic cigarettes were developed to deliver a nicotine vapor such that smokers could simulate smoking tobacco without the inherent pathology of inhaled tobacco smoke. With four states within the USA having legalized the cultivation, distribution and recreational use of marijuana and an additional 23 states plus the District of Columbia with laws that legalize marijuana in some form, it was inevitable that suppliers of legal marijuana would develop marijuana products for use in these electronic cigarettes...
June 2016: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/26929665/a-urinary-test-procedure-for-identification-of-cannabidiol-in-patients-undergoing-medical-therapy-with-marijuana
#14
Paul T Wertlake, Michael D Henson
Marijuana is classified by the Drug Enforcement Agency (DEA) as Schedule I, drugs having no accepted medical value. Twenty-three states and the District of Columbia have legalized medical marijuana. This conflict inhibits physicians from prescribing marijuana and the systematic study of marijuana in medical care. This study concerns the use of the clinical laboratory as a resource for physicians recommending cannabidiol (CBD) to patients, or for patients using medical marijuana. Marijuana containing delta-9-tetrahydrocannabinol (THC) is psychoactive...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/26772776/cannabidiol-limits-tcell-mediated-chronic-autoimmune-myocarditis-implications-to-autoimmune-disorders-and-organ-transplantation
#15
Wen-Shin Lee, Katalin Erdelyi, Csaba Matyas, Partha Mukhopadhyay, Zoltan V Varga, Lucas Liaudet, György Haskó, Daniela Čiháková, Raphael Mechoulam, Pal Pacher
RATIONALE: Myocarditis is a major cause of heart failure and sudden cardiac death in young adults and adolescents. Many cases of myocarditis are associated with autoimmune processes in which cardiac myosin is a major autoantigen. Conventional immunosuppressive therapies often provide unsatisfactory results and are associated with adverse toxicities during the treatment of autoimmune myocarditis. Cannabidiol (CBD) is a non-psychoactive constituent of Marijuana which exerts antiinflammatory effects independent from classical cannabinoid receptors...
January 8, 2016: Molecular Medicine
https://www.readbyqxmd.com/read/26746824/seized-cannabis-seeds-cultivated-in-greenhouse-a-chemical-study-by-gas-chromatography-mass-spectrometry-and-chemometric-analysis
#16
Kristiane de Cássia Mariotti, Marcelo Caetano Alexandre Marcelo, Rafael S Ortiz, Bruna Tassi Borille, Monique Dos Reis, Mauro Sander Fett, Marco Flôres Ferrão, Renata Pereira Limberger
Cannabis sativa L. is cultivated in most regions of the world. In 2013, the Brazilian Federal Police (BFP) reported 220 tons of marijuana seized and about 800,000 cannabis plants eradicated. Efforts to eradicate cannabis production may have contributed to the development of a new form of international drug trafficking in Brazil: the sending of cannabis seeds in small amounts to urban centers by logistics postal. This new and increasing panorama of cannabis trafficking in Brazil, encouraged the chemical study of cannabis seeds cultivated in greenhouses by gas-chromatography coupled with mass spectrometry (GC-MS) associated with exploratory and discriminant analysis...
January 2016: Science & Justice: Journal of the Forensic Science Society
https://www.readbyqxmd.com/read/26336632/clinical-perspectives-on-medical-marijuana-cannabis-for-neurologic-disorders
#17
Terry D Fife, Heidi Moawad, Constantine Moschonas, Katie Shepard, Nancy Hammond
The American Academy of Neurology published an evidence-based systematic review of randomized controlled trials using marijuana (Cannabis sativa) or cannabinoids in neurologic disorders. Several cannabinoids showed effectiveness or probable effectiveness for spasticity, central pain, and painful spasms in multiple sclerosis. The review justifies insurance coverage for dronabinol and nabilone for these indications. Many insurance companies already cover these medications for other indications. It is unlikely that the review will alter coverage for herbal marijuana...
August 2015: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/26308126/a-study-of-the-use-knowledge-and-beliefs-about-cigarettes-and-alternative-tobacco-products-among-students-at-one-u-s-medical-school
#18
Sherry Zhou, Nancy Van Devanter, Michael Fenstermaker, Philip Cawkwell, Scott Sherman, Michael Weitzman
PURPOSE: In the United States, the prevalence of the use of alternative tobacco products (ATPs) (e.g., hookahs, e-cigarettes, cigars/cigarillos) has increased sharply. As future health care providers, medical students will play a critical role in health promotion and disease prevention. This study investigated medical students' use, knowledge, and beliefs about cigarettes and ATPs. METHOD: In 2014, the authors surveyed all students enrolled at one medical school in New York City...
December 2015: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/26103031/medical-marijuana-for-treatment-of-chronic-pain-and-other-medical-and-psychiatric-problems-a-clinical-review
#19
REVIEW
Kevin P Hill
IMPORTANCE: As of March 2015, 23 states and the District of Columbia had medical marijuana laws in place. Physicians should know both the scientific rationale and the practical implications for medical marijuana laws. OBJECTIVE: To review the pharmacology, indications, and laws related to medical marijuana use. EVIDENCE REVIEW: The medical literature on medical marijuana was reviewed from 1948 to March 2015 via MEDLINE with an emphasis on 28 randomized clinical trials of cannabinoids as pharmacotherapy for indications other than those for which there are 2 US Food and Drug Administration-approved cannabinoids (dronabinol and nabilone), which include nausea and vomiting associated with chemotherapy and appetite stimulation in wasting illnesses...
June 23, 2015: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/25649017/the-therapeutic-potential-of-cannabinoids-for-movement-disorders
#20
REVIEW
Benzi Kluger, Piera Triolo, Wallace Jones, Joseph Jankovic
There is growing interest in the therapeutic potential of marijuana (cannabis) and cannabinoid-based chemicals within the medical community and, particularly, for neurological conditions. This interest is driven both by changes in the legal status of cannabis in many areas and increasing research into the roles of endocannabinoids within the central nervous system and their potential as symptomatic and/or neuroprotective therapies. We review basic science as well as preclinical and clinical studies on the therapeutic potential of cannabinoids specifically as it relates to movement disorders...
March 2015: Movement Disorders: Official Journal of the Movement Disorder Society
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