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https://www.readbyqxmd.com/read/29221299/surgical-site-infections-after-lung-resection-a-prospective-study-of-risk-factors-in-1-091-consecutive-patients
#1
Andrea Imperatori, Elisa Nardecchia, Lorenzo Dominioni, Daniele Sambucci, Sebastiano Spampatti, Giancarlo Feliciotti, Nicola Rotolo
Background: To assess incidence and risk factors of surgical site infections (SSI) (wound infection, pneumonia, empyema) in a monocentric series of patients undergoing lung resection over a decade. Methods: All patients undergoing lung resection at our institution in 2006-2015 [wedge resection, n=579; lobectomy, n=472 (12% after chemo/radiotherapy); pneumonectomy, n=40 (47% after chemo/radiotherapy)], were prospectively enrolled. Perioperative SSI risk factors were recorded: age, gender, blood haemoglobin, lymphocyte count, serum albumin, forced expiratory volume in 1 second percentage (FEV1%) of predicted, antibiotic prophylaxis, length of stay, diabetes, malignancy, steroid therapy, induction chemo/radiotherapy, resection in 2006-2010/2011-2015, urgent/elective procedure, videothoracoscopic/open approach, resection type, operative time...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29220430/postoperative-outcomes-in-ustekinumab-treated-patients-undergoing-abdominal-operations-for-crohn-s-disease
#2
Amy L Lightner, Nicholas P McKenna, Chung Sang Tse, Neil Hyman, Radhika Smith, Gayane Ovsepyan, Phillip Fleshner, Kristen Crowell, Walter Koltun, Marc Ferrante, Andre D'Hoore, Nathalie Lauwers, Bram Verstockt, Antonino Spinelli, Francesca DiCandido, Laura E Raffals, Kellie L Mathis, Edward V Loftus
Introduction: Ustekinumab, a monoclonal antibody targeting interleukins-12 and -23 is used to treat adults with Crohn's disease (CD). We determined the 30-day postoperative infectious complication rate among CD patients who received ustekinumab within 12 weeks prior to an abdominal operation as compared to patients who received anti-tumor necrosis factor (TNF) agents. Methods: A retrospective chart review of adults with CD who underwent an abdominal operation between 1/1/2015 and 5/1/2017 was performed across six sites...
December 6, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29217176/a-strong-adjuvant-based-on-glycol-chitosan-coated-lipid-polymer-hybrid-nanoparticles-potentiates-mucosal-immune-responses-against-the-recombinant-chlamydia-trachomatis-fusion-antigen-cth522
#3
Fabrice Rose, Jeanette Erbo Wern, Francesca Gavins, Peter Andersen, Frank Follmann, Camilla Foged
Induction of mucosal immunity with vaccines is attractive for the immunological protection against pathogen entrance directly at the site of infection. An example is infection with Chlamydia trachomatis (Ct), which is the most common sexually transmitted infection in the world, and there is an unmet medical need for an effective vaccine. A vaccine against Ct should elicit protective humoral and cell-mediated immune (CMI) responses in the genital tract mucosa. We previously designed an antibody- and CMI-inducing adjuvant based on poly(dl-lactic-co-glycolic acid) (PLGA) nanoparticles modified with the cationic surfactant dimethyldioctadecylammonium bromide and the immunopotentiator trehalose-6,6'-dibehenate...
December 4, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29216315/the-pul37-tegument-protein-guides-alpha-herpesvirus-retrograde-axonal-transport-to-promote-neuroinvasion
#4
Alexsia L Richards, Patricia J Sollars, Jared D Pitts, Austin M Stults, Ekaterina E Heldwein, Gary E Pickard, Gregory A Smith
A hallmark property of the neurotropic alpha-herpesvirinae is the dissemination of infection to sensory and autonomic ganglia of the peripheral nervous system following an initial exposure at mucosal surfaces. The peripheral ganglia serve as the latent virus reservoir and the source of recurrent infections such as cold sores (herpes simplex virus type I) and shingles (varicella zoster virus). However, the means by which these viruses routinely invade the nervous system is not fully understood. We report that an internal virion component, the pUL37 tegument protein, has a surface region that is an essential neuroinvasion effector...
December 7, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29215475/an-effective-bundled-approach-reduces-surgical-site-infections-in-a-high-outlier-colorectal-unit
#5
Emre Gorgun, Ahmet Rencuzogullari, Volkan Ozben, Luca Stocchi, Thomas Fraser, Cigdem Benlice, Tracy Hull
BACKGROUND: Surgical site infections are the most common hospital-acquired infection after colorectal surgery, increasing morbidity, mortality, and hospital costs. OBJECTIVE: The purpose of this study was to investigate the impact of preventive measures on colorectal surgical site infection rates in a high-volume institution that performs inherent high-risk procedures. DESIGN: This was a prospective cohort study. SETTINGS: The study was conducted at a high-volume, specialized colorectal surgery department...
January 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29214396/triple-management-of-cubitus-valgus-deformity-complicating-neglected-nonunion-of-fractures-of-lateral-humeral-condyle-in-children-a-case-series
#6
Yasser Abed, Khaled Nour, Yasser Roshdy Kandil, Abed El-Negery
BACKGROUND: Long standing nonunion of the lateral humeral condyle (LHC) usually results in elbow pain and instability with progressive cubitus valgus and tardy ulnar neuritis. Surgical treatment of long standing nonunion is still a controversial issue due to the reported complications, such as stiffness, loss of elbow motion, and avascular necrosis of the LHC fragment. In this study, we reported the outcomes of treatment of cubitus valgus deformity in long standing nonunion of the LHC in children treated with combined triple management (fixation of the nonunion site, dome corrective osteotomy, and anterior transposition of ulnar nerve) through a modified para-triceptal approach...
December 6, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/29212689/minimally-invasive-surgery-for-adolescent-idiopathic-scoliosis-correction-of-deformity-and-peri-operative-morbidity-in-70-consecutive-patients
#7
C de Bodman, F Miyanji, B Borner, P-Y Zambelli, G Racloz, R Dayer
AIMS: The aim of this study was to report a retrospective, consecutive series of patients with adolescent idiopathic scoliosis (AIS) who were treated with posterior minimally invasive surgery (MIS) with a mean follow-up of two years (sd 1.4; 0.9 to 0 3.7). Our objectives were to measure the correction of the deformity and record the peri-operative morbidity. Special attention was paid to the operating time (ORT), estimated blood loss (EBL), length of stay (LOS) and further complications...
December 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/29205141/deep-spinal-infection-in-instrumented-spinal-surgery-diagnostic-factors-and-therapy
#8
M Dobran, A Marini, M Gladi, D Nasi, R Colasanti, R Benigni, Francesca Mancini, M Iacoangeli, M Scerrati
AIM: Postoperative surgical site infections (SSI) are complication of spinal surgery. These complications may lead to a poor outcome with neurological deficits, spinal deformity and chronic pain. The purpose of this study is to explore the statistical value of diagnostic parameters and the proper therapy. METHOD: We retrospectively reviewed 550 patients who underwent spinal instrumentation at our department from January 2011 to December 2015. The SSI was present in 16 patients out of 550 operated...
May 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29202994/functional-outcomes-following-surgical-site-infections-after-operative-fixation-of-closed-ankle-fractures
#9
Markus G Naumann, Ulf Sigurdsen, Stein Erik Utvåg, Knut Stavem
BACKGROUND: To compare the functional outcomes between patients with and without postoperative surgical-site infection (SSI) after surgical treatment in closed ankle fractures. METHODS: Retrospective cohort study with prospective follow-up. Of 1011 treated patients, 959 were eligible for inclusion in a postal survey. Functional outcomes were assessed using three self-reported questionnaires. RESULTS: In total 567 patients responded a median of 4...
December 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29198677/single-donor-derived-pseudomonas-aeruginosa-pseudoaneurysms-in-two-kidney-transplant-recipients-a-case-report-of-dichotomous-allograft-outcomes
#10
M F Berger, I R Badell
Infectious pseudoaneurysm (IPA) is a rare but devastating complication following renal transplantation that typically leads to graft loss and occasionally patient death. IPAs following kidney transplantation are most often mycotic in etiology, but have been sporadically reported to result from Pseudomonas aeruginosa infection. These IPAs occur at various anatomic sites, most commonly at the vascular anastomosis or iliac artery, and very rarely in the transplanted renal artery or hilum. Here we report the occurrence of single donor-derived P aeruginosa IPAs in two kidney transplant recipients with divergent allograft outcomes...
December 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29198571/wearing-long-sleeves-while-prepping-a-patient-in-the-operating-room-decreases-airborne-contaminants
#11
Troy A Markel, Thomas Gormley, Damon Greeley, John Ostojic, Jennifer Wagner
BACKGROUND: The use of long sleeves by nonscrubbed personnel in the operating room has been called into question. We hypothesized that wearing long sleeves and gloves, compared with having bare arms without gloves, while applying the skin preparation solution would decrease particulate and microbial contamination. METHODS: A mock patient skin prep was performed in 3 different operating rooms. A long-sleeved gown and gloves, or bare arms, were used to perform the procedure...
November 30, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/29195912/procedure-specific-trends-in-surgical-outcomes
#12
Jason B Liu, Julia R Berian, Yaoming Liu, Mark E Cohen, Clifford Y Ko, Bruce L Hall
BACKGROUND: Quality improvement efforts have generally focused on hospital benchmarking, and processes and outcomes shared among all operations. However, quality improvement could be inconsistent across different types of operations. The objective of this study was to identify operations needing additional concerted quality improvement efforts by examining their outcomes trends. STUDY DESIGN: Ten procedures (colectomy, esophagectomy, hepatectomy, hysterectomy, pancreatectomy, proctectomy, total hip arthroplasty, total knee arthroplasty, thyroidectomy, and ventral hernia repair) commonly accrued into the American College of Surgeons NSQIP between 2008 and 2015 were included...
November 7, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29193653/incidence-and-risk-factors-for-deep-surgical-site-infection-after-open-reduction-and-internal-fixation-of-closed-tibial-plateau-fractures-in-adults
#13
Qiang Ma, Abulaiti Aierxiding, Guosheng Wang, Chengwei Wang, Lijuan Yu, Zhimin Shen
This study aimed to investigate the incidence and risk factors of deep surgical site infection (DSSI) during hospitalisation after closed tibial plateau fractures treated with open reduction and internal fixation (ORIF). We performed this retrospective study at a university-affiliated hospital with an advanced trauma centre. The data of adult patients with closed tibial plateau fractures treated with ORIF from January 2012 to February 2017 were extracted from the electronic medical records. Demographics, injury-related and surgery-related variables of DSSI and non-DSSI groups were compared by univariate test...
November 29, 2017: International Wound Journal
https://www.readbyqxmd.com/read/29193009/do-perioperative-antibiotics-reduce-the-risk-of-surgical-site-infections-following-excision-of-ulcerated-skin-cancers-a-critically-appraised-topic
#14
S A Chan, A G H Wernham, N Stembridge, N Harper, S Verykiou, G A Fremlin, R A Abbott, R N Matin
AIM: To review the efficacy of perioperative antibiotics in reducing the risk of surgical site infections (SSI) following excision of ulcerated skin cancers. SETTING AND DESIGN: Study selection, data extraction and analysis were carried out independently by four authors. Only randomised controlled trials (RCTs) reported in the English Language were included. INCLUDED STUDIES: Randomised controlled trials (RCTs) in the English language in which patients received perioperative topical, intralesional, or oral antibiotics for dermatological surgery including Mohs micrographic surgery in General Practice, Dermatology or Plastic Surgery Departments were included...
November 28, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29191213/modified-pedicle-screw-rod-fixation-versus-anterior-pelvic-external-fixation-for-the-management-of-anterior-pelvic-ring-fractures-a-comparative-study
#15
Chun Bi, Qiugen Wang, Jianhong Wu, Feng Zhou, Fei Zhang, Haipeng Liang, Fei Lyu, Jiandong Wang
BACKGROUND: Anterior pelvic ring fracture, as high-energy trauma, needs to be effectively treated. The purpose of the current study was to evaluate the clinical applications of modified pedicle screw-rod fixation and anterior pelvic external fixation for the treatment of anterior pelvic ring fracture. METHODS: Either modified pedicle screw-rod fixation (modified PSRF group, N = 21) or anterior pelvic external fixation (APEF group, N = 22) was performed to 43 patients, with or without fixation of posterior ring...
December 1, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29188131/an-outbreak-of-pseudomonas-aeruginosa-infection-linked-to-a-black-friday-piercing-event
#16
Peter MacPherson, Katherine Valentine, Victoria Chadderton, Evdokia Dardamissis, Ian Doig, Andrew Fox, Sam Ghebrehewet, Tom Hampton, Ken Mutton, Claire Sherratt, Catherine M McCann
Introduction: Outbreaks linked to cosmetic piercing are rare, but can cause significant illness. We report the investigation and management of a point-source outbreak that occurred during a Black Friday promotional event in North West England. Methods: Outbreak investigation was led by Public Health England, and included active case finding among individuals pierced at a piercing premises between 25/11/2016 (Black Friday) and 7/12/2016. Detailed epidemiological, environmental (including inspection and sampling), and microbiological investigation was undertaken...
October 16, 2017: PLoS Currents
https://www.readbyqxmd.com/read/29184720/risk-factors-for-wound-complications-following-spine-surgery
#17
Keaton F Piper, Samuel B Tomlinson, Gabrielle Santangelo, Joseph Van Galen, Ian DeAndrea-Lazarus, James Towner, Kristopher T Kimmell, Howard Silberstein, George Edward Vates
Background: Wound complications, including surgical site infections (SSIs) and wound dehiscence, are among the most common complications following spine surgery often leading to readmission. The authors sought to identify preoperative characteristics predictive of wound complications after spine surgery. Methods: The American College of Surgeons National Surgical Quality Improvement Program database for years 2012-2014 was reviewed for patients undergoing spine surgery, defined by the Current Procedural Terminology codes...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29178906/femoral-nonunion-with-segmental-bone-defect-treated-by-distraction-osteogenesis-with-monolateral-external-fixation
#18
Qun Zhang, Wei Zhang, Zhuo Zhang, Licheng Zhang, Hua Chen, Ming Hao, Junhao Deng, Peifu Tang
BACKGROUND: Currently, the common treatment for femoral nonunion with large segmental bone defect is difficult and complex. The effective surgical methods are rare, include vascularized bone grafting, Masquelet technique and Ilizarov distraction osteogenesis. The objective of this study is to investigate the outcomes of segmental femoral defects treated with monolateral external fixation using the distraction osteogenesis. METHODS: We retrospectively analyzed patients with femoral nonunion with segmental bone defects (> 6 cm) between January 2010 and January 2014 in our single trauma center...
November 25, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29174848/-back-loss-cover-in-orthopedic-surgery-by-helical-lumbar-perforator-flaps-about-6-cases
#19
L Ruffenach, E Robert, C Dissaux, C Bruant-Rodier, F Bodin
INTRODUCTION: The existence of voluminous paralumbar perforators allows a simplification of the coverage of the lumbar region. MATERIALS AND METHODS: The authors present a series about lumbar loss substance following orthopedic surgery, from 2012 to 2017. Coverage was provided by a fascio-cutaneous lumbar perforator flap. RESULTS: Six patients were operated with mean age of 62.3 years, with an average follow-up of 16 months (up 6 to 41 months)...
November 23, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/29172710/low-rates-of-post-craniotomy-surgical-site-infections-in-a-developing-country-surgical-technique-and-results
#20
Amos O Adeleye
INTRODUCTION: Although neurosurgical surgical site infections (SSI) exert a devastating price on the postoperative course of patients in the developing countries, literature is sparse on the subject from these regions. METHODS: This study is an audit of post-craniotomy SSI in a sub-Sahara African academic neurosurgical practice. It is a retrospective descriptive analysis of neurosurgical SSI in a 7-year consecutive cohort of patients who survived more than 5 days following major cranial surgery...
November 24, 2017: British Journal of Neurosurgery
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