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https://www.readbyqxmd.com/read/29169184/her2-expression-patterns-in-paired-primary-and-metastatic-endometrial-cancer-lesions
#1
Mari Kyllesø Halle, Ingvild Løberg Tangen, Hege Fredriksen Berg, Erling Andre Hoivik, Karen K Mauland, Kanthida Kusonmano, Anna Berg, Antoni Hurtado, Karl Henning Kalland, Anne M Øyan, Ingunn Stefansson, Olav K Vintermyr, Henrica M Werner, Ingfrid S Haldorsen, Jone Trovik, Helga B Salvesen, Camilla Krakstad
BACKGROUND: Despite successful implementation of drugs targeting the human epidermal growth factor receptor 2 (HER2) receptor in breast and gastric cancers, the potential of HER2 as a therapeutic target in other cancers has been less studied, including endometrial cancer. We investigated expression levels of HER2 (ERBB2) in a large cohort of endometrial cancer lesions, also including complex atypical hyperplasia and metastatic lesions. METHODS: 67 precursor lesions, 790 primary endometrial cancers and 383 metastatic lesions were investigated for HER2 expression in relation to clinicopathologic features and outcome...
November 23, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29169153/optimal-trough-concentration-of-teicoplanin-in-febrile-neutropenic-patients-with-hematological-malignancy
#2
Yuhki Sato, Kazufumi Hiramatsu, Yosuke Suzuki, Ryota Tanaka, Tetsuya Kaneko, Ko Nonoshita, Masao Ogata, Jun-Ichi Kadota, Hiroki Itoh
BACKGROUND: Teicoplanin is a glycopeptide antibiotic currently used for the treatment of methicillin-resistant Staphylococcus aureus. The need for therapeutic drug monitoring of teicoplanin has been increasingly highlighted as important. It is generally accepted that whereas a plasma trough concentration (Cmin) of ≥10 mg/L is appropriate for the majority of infections, it should exceed 20 mg/L for severe infections. The target Cmin of teicoplanin in patients with febrile neutropenia (FN) has not been reported...
November 24, 2017: Chemotherapy
https://www.readbyqxmd.com/read/29169150/multiple-roles-of-autophagy-in-the-sorafenib-resistance-of-hepatocellular-carcinoma
#3
Ting Sun, Hongchun Liu, Liang Ming
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide, and prognosis remains unsatisfactory since the disease is often diagnosed at the advanced stages. Currently, the multikinase inhibitor sorafenib is the only drug approved for the treatment of advanced HCC. However, primary or acquired resistance to sorafenib develops, generating a roadblock in HCC therapy. Autophagy is an intracellular lysosomal pathway involved in protein and organelle degradation, with an astonishing number of connections to human disease and physiology...
November 23, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29169069/anti-inflammatory-agents-in-peripheral-arterial-disease
#4
REVIEW
Alexios S Antonopoulos, Evi Papanikolaou, Georgia Vogiatzi, Evangelos Oikonomou, Dimitris Tousoulis
Inflammation is pivotally involved in coronary and peripheral atherosclerotic disease. This established concept is based on both experimental animal models of vascular inflammation and Mendelian randomization studies demonstrating a causal relationship between pro-inflammatory cytokines (e.g. interleukin-6) and cardiovascular disease risk. More recently, the reduction of cardiovascular events by use of an interleukin-1β inhibitor (canakinumab) has revived interest in the use of anti-inflammatory agents for the treatment of atherosclerotic disease, including peripheral arterial disease...
November 20, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29169001/ivacaftor-for-cystic-fibrosis-an-evaluation-of-real-world-utilisation-and-expenditure-in-the-irish-healthcare-setting
#5
A Corcoran, N Hickey, M Barry, C Usher, L M McCullagh
In Ireland, Ivacaftor is reimbursed, on the High-Tech Drug Scheme, for the treatment of cystic fibrosis in patients age 6 years and older who have the G551D mutation. The aim of this study was to analyse the utilisation and expenditure of Ivacaftor on this scheme in the 12 month period post-reimbursement. All patients who had received Ivacaftor (regardless of General Medical Services Scheme eligibility/ineligibility) were included. A total of 140 individuals (male=74; 53%) received Ivacaftor over the defined 12 month study period (from January 2015 to December 2015 inclusive)...
August 12, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/29168987/independent-predictors-of-effective-blood-pressure-control-in-patients-with-hypertension-on-drug-treatment-in-brazil
#6
Francisco Flavio Costa Filho, Ari Timerman, Jose Francisco Kerr Saraiva, Carlos Costa Magalhaes, Ibraim Masciarelli F Pinto, Gustavo B F Oliveira, Antonio Cordeiro Mattos, Alvaro Avezum
Population assessment of effective blood pressure (BP) control is fundamental for reducing the global burden of hypertension, especially in low- and middle-income countries. The authors evaluated the effectiveness of BP control and determined independent predictors associated with effective control among patients with hypertension on drug treatment in a large cross-sectional study performed in two metropolitan areas in Brazil's southeast region. A total of 43 647 patients taking antihypertensive treatment were identified...
November 23, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29168896/healing-of-self-inflicted-thermal-injury-of-palatal-mucosa-by-low-level-laser-therapy
#7
Abdul Ahad, Shazra Tasneem, Arundeep Kaur Lamba, Saif Khan
Self-inflicted injury to oral mucosa is a rare entity. These injuries can be premeditated, accidental, or can result from an abnormal habit. These uncommon gingival injuries can sometimes test the clinician's diagnostic abilities as well as treatment planning skills. In conventional treatment, removal of etiology and application of topical drugs is usually sufficient for healing. However, some cases require alternative or adjunctive wound healing methods. Low-level laser therapy (LLLT) has been reported to be effective in pain management and improvement in wound healing through promotion, fortification, and commissioning of cellular cycle to generate productive and substitute cells...
November 23, 2017: Special Care in Dentistry
https://www.readbyqxmd.com/read/29168788/microtubule-depolymerization-by-kinase-inhibitors-unexpected-findings-of-dual-inhibitors
#8
REVIEW
Kenji Tanabe
Microtubule-targeting agents are widely used as clinical drugs in the treatment of cancer. However, some kinase inhibitors can also disrupt microtubule organization by directly binding to tubulin. These unexpected effects may result in a plethora of harmful events and/or a misinterpretation of the experimental results. Thus, further studies are needed to understand these dual inhibitors. In this review, I discuss the roles of dual inhibitors of kinase activity and microtubule function as well as describe the properties underlining their dual roles...
November 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29168696/correlation-between-entecavir-penetration-in-peripheral-blood-mononuclear-cells-and-hbv-dna-decay-during-treatment-of-hbeag-negative-chronic-hepatitis-b
#9
Amedeo De Nicolò, Lucio Boglione, Jessica Cusato, Giovanna Fatiguso, Fabio Favata, Sarah Allegra, Giuseppe Cariti, Giovanni Di Perri, Antonio D'Avolio
BACKGROUND: Recently, due to its high effectiveness and tolerability, the treatment of chronic hepatitis B with entecavir became a standard practice. However, limited knowledge is currently available about its pharmacokinetic behavior and intracellular disposition. Recently, our group reported an inverse correlation between entecavir plasma concentrations and the HBV DNA decay at the first and third month of treatment, respectively. ​: In this paper we investigated the disposition of entecavir in peripheral blood mononuclear cells (PBMC) and in plasma, in order to evaluate the relationship between intracellular penetration and response, in a cohort of naïve patients with HBeAg-negative CHB...
November 23, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/29168673/the-role-of-dalbavancin-in-the-multi-disciplinary-management-of-wound-infections-in-orthopaedic-surgery
#10
Fabio Arena, Emilio Romanini, Elia Rosi, Carlo Salomone, Gabriele Tucci, Ciro Pempinello, Massimo Fantoni
Antimicrobial resistance is continuously increasing among bacterial clinical isolates (especially methicillin resistance in Staphylococcus aureus, MRSA), negatively impacting on outcomes of patients with Surgical Site Infections (SSIs). A multi-disciplinary team work is essential for SSIs prevention and for the choice of antibiotic therapy of orthopaedic SSIs. In particular, an Antibiotic Stewardship (AS) approach is recommended for preserving the activity of old and new antimicrobials. Dalbavancin is a novel antimicrobial agent, belonging to the lipoglycopeptides family, recently approved by FDA for the treatment of ABSSSIs (Acute Bacterial Skin and Skin Structure Infections) and can be considered as a candidate for the treatment of orthopaedic superficial SSIs...
November 23, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29168605/what-psychologists-need-to-know-about-psychotropic-medications
#11
Elena Tomba, Jenny Guidi, Giovanni A Fava
Despite the fact that today most of the patients with psychological disturbances assume some form of psychotropic drug treatment, clinical psychologists may have little familiarity with psychopharmacology and are substantially unaware of subtle and yet pervasive potential effects of medications in clinical presentations. In their training, psychologists are generally exposed, at best, to some general principles of drug action. Standard psychopharmacology textbooks tend to omit the subtle psychological changes that may occur during psychotropic drug treatment...
November 23, 2017: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/29168557/probiotics-for-vulvovaginal-candidiasis-in-non-pregnant-women
#12
REVIEW
Huan Yu Xie, Dan Feng, Dong Mei Wei, Ling Mei, Hui Chen, Xun Wang, Fang Fang
BACKGROUND: Vulvovaginal candidiasis (VVC) is estimated to be the second most common form of infection after bacterial vaginosis. The ability of probiotics in maintaining and recovering the normal vaginal microbiota, and their potential ability to resist Candidas give rise to the concept of using probiotics for the treatment of VVC. OBJECTIVES: To assess the effectiveness and safety of probiotics for the treatment of vulvovaginal candidiasis in non-pregnant women...
November 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29168468/strontium-chloride-hexahydrate-as-a-candidate-molecule-for-long-term-treatment-of-allergic-rhinitis
#13
Emine Elif Altuntas, Nergiz Hacer Turgut, Kasım Durmuş, Ömer Tamer Doǧan, Melih Akyol
BACKGROUND & OBJECTIVES: Neurogenic inflammation plays a role in the pathophysiology of allergic rhinitis (AR). Strontium salts are highly effective in reducing the sensory irritation. This study was aimed to investigate the efficacy of strontium chloride (SC) on AR symptoms based on the duration of SC use before the symptoms begin. METHODS: Wistar albino rats (n=18) were randomly divided into three groups: Group 1, received 1μg mometasone furoate (MF); Group 2, three per cent SC; and Group 3 received five per cent SC (2 μl/site)...
July 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29168457/newer-direct-acting-antivirals-for-hepatitis-c-virus-infection-perspectives-for-india
#14
REVIEW
Varun Gupta, Ashish Kumar, Praveen Sharma, Anil Arora
Approximately three per cent of the world's population (170-200 million people) is chronically infected with hepatitis C virus (HCV) and almost 500,000 people die each year (mostly in lower middle-income countries) from complications secondary to HCV infection. In India, HCV infection imposes a considerable burden of mortality, morbidity and healthcare costs. In the last two decades, the treatment of HCV has evolved from interferon (IFN)-based therapies with or without ribavirin (RBV) to pegylated-IFN (PEG-IFN) and RBV-based therapies that were better tolerated by patients...
July 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29168384/tracking-silent-hypersensitivity-reactions-to-asparaginase-during-leukemia-therapy-using-single-chip-indirect-plasmonic-and-fluorescence-immunosensing
#15
David M Charbonneau, Julien Breault-Turcot, Daniel Sinnett, Maja Krajinovic, Jean-Marie Leclerc, Jean-François Masson, Joelle N Pelletier
Microbial asparaginase is an essential component of chemo-therapy for the treatment of childhood acute lymphoblastic leukemia (cALL). Silent hypersensitivity reactions to this microbial enzyme need to be monitored accurately during treatment to avoid adverse effects of the drug and its silent inactivation. Here, we present a dual-response anti-asparaginase sensor that combines indirect SPR and fluo-rescence on a single chip to perform ELISA-type immunosensing, and correlate measurements with classical ELISA...
November 23, 2017: ACS Sensors
https://www.readbyqxmd.com/read/29168317/hepatitis-c-virus-prevalence-and-associated-risk-factors-among-indigenous-australians-who-inject-drugs
#16
Michael Doyle, Lisa Maher, Simon Graham, Handan Wand, Jenny Iversen
OBJECTIVE: To examine factors associated with hepatitis C virus (HCV) infection among a national sample of Indigenous and non-Indigenous people who inject drugs (PWID) in Australia. METHODS: Respondents were recruited from Australia's Needle Syringe Program Survey; an annual bio-behavioural surveillance project that monitors HCV antibody prevalence among PWID. Data from 2006-2015 were de-duplicated to retain only one record where individuals participated in >1 survey round...
November 22, 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/29168312/curcumin-mediated-down-regulation-of-%C3%AE-v-%C3%AE-3-integrin-and-up-regulation-of-pyruvate-dehydrogenase-kinase-4-pdk4-in-erlotinib-resistant-sw480-colon-cancer-cells
#17
Samira Javadi, Kobra Rostamizadeh, Jalal Hejazi, Maliheh Parsa, Mojtaba Fathi
Erlotinib is a potent, selective, and orally active inhibitor of the epidermal growth factor receptor, but the development of erlotinib resistance during chemotherapy can lead to treatment failure. To shed light on the erlotinib-resistant pathway, this study investigated the effect of combination therapy using curcumin- and erlotinib-loaded nanoparticles on the expression of αv β3 integrin and pyruvate dehydrogenase kinase 4 (PDK4) in an erlotinib-resistant SW480 colon cancer cell line. An erlotinib-resistant SW480 colon cancer cell line was produced by long-term exposure to erlotinib...
November 23, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29168292/evaluation-of-the-effect-of-quercetin-treatment-on-cyp2c9-enzyme-activity-of-diclofenac-in-healthy-human-volunteers
#18
Satish Kumar Bedada, Prasad Neerati
The purpose of present study was to evaluate the effect of quercetin on pharmacokinetics of diclofenac sodium (DIC) in healthy volunteers. The open-label, 2 period, sequential study was conducted in 12 healthy volunteers. DIC 100 mg was administered during control and after quercetin phases. Quercetin 500 mg was administered twice daily for 10 days during quercetin phase. Treatment with quercetin significantly enhanced maximum plasma concentration (Cmax ), area under the curve (AUC0-∞ ), and half life, while significantly decreased elimination rate constant (kel ) and apparent oral clearance (CL/F) of DIC compared with control...
November 23, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29168263/incidence-and-predictors-of-mental-health-disorder-diagnoses-among-people-who-inject-drugs-in-a-canadian-setting
#19
Hudson Reddon, Tyler Pettes, Evan Wood, Ekaterina Nosova, Michael-John Milloy, Thomas Kerr, Kanna Hayashi
INTRODUCTION AND AIMS: Limited attention has been given to the predictors of mental health diagnoses among people who inject drugs (PWID) in community settings. Therefore, we sought to longitudinally examine the prevalence, incidence and predictors of mental disorder diagnosis among a community-recruited cohort of PWID. DESIGN AND METHODS: Data were derived from two prospective cohort studies of PWID (VIDUS and ACCESS) in Vancouver, Canada between December 2005 and May 2015...
November 22, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/29168261/-impact-of-drug-reimbursement-policies-on-prescribing-a-case-study-of-a-newly-marketed-long-acting-injectable-antipsychotics-among-relapsed-schizophrenia-patients
#20
John W Jackson, Lisa Fulchino, James Rogers, Helen Mogun, Jennifer Polinski, David C Henderson, Sebastian Schneeweiss, Michael A Fischer
OBJECTIVE: To quantify and explain variation in use of long-acting injectable antipsychotics (LAIs) in the United States, and understand the relationship between patient characteristics, drug reimbursement policies, and LAI prescribing after relapse. METHODS: A cohort of recently relapsed patients with schizophrenia ages 18 to 64, identified immediately after discharge from a related inpatient hospitalization, partial hospitalization, or emergency room visit, drawn from 2004 to 2006 Medicaid claims, and followed for 90 days until LAI initiation...
November 23, 2017: Pharmacoepidemiology and Drug Safety
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