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https://www.readbyqxmd.com/read/28543915/cross-sectional-correlation-between-hepatic-r2-and-proton-density-fat-fraction-pdff-in-children-with-hepatic-steatosis
#1
Adrija Mamidipalli, Gavin Hamilton, Paul Manning, Cheng William Hong, Charlie C Park, Tanya Wolfson, Jonathan Hooker, Elhamy Heba, Alexandra Schlein, Anthony Gamst, Janis Durelle, Melissa Paiz, Michael S Middleton, Jeffrey B Schwimmer, Claude B Sirlin
PURPOSE: To determine the relationship between hepatic proton density fat fraction (PDFF) and R2* in vivo. MATERIALS AND METHODS: In this Health Insurance Portability and Accountability Act (HIPAA)-compliant, Institutional Review Board (IRB)-approved, cross-sectional study, we conducted a secondary analysis of 3T magnetic resonance imaging (MRI) exams performed as part of prospective research studies in children in whom conditions associated with iron overload were excluded clinically...
May 25, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28540506/assessing-the-feasibility-of-the-effectiveness-of-discontinuing-bisphosphonates-trial-a-pilot-study
#2
N C Wright, P J Foster, A S Mudano, J A Melnick, M E Lewiecki, W J Shergy, J R Curtis, G R Cutter, M I Danila, M L Kilgore, E C Lewis, S L Morgan, D T Redden, A H Warriner, K G Saag
The Effectiveness of Discontinuing Bisphosphonates (EDGE) study is a planned pragmatic clinical trial to guide "drug holiday" clinical decision making. This pilot study assessed work flow and feasibility of such a study. While participant recruitment and treatment adherence were suboptimal, administrative procedures were generally feasible and minimally disrupted clinic flow. INTRODUCTION: The comparative effectiveness of continuing or discontinuing long-term alendronate (ALN) on fractures is unknown...
May 24, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28535711/applications-for-research-concerning-fetal-or-placental-tissue-and-expected-institutional-review-board-responses
#3
Lynn Borgatta, David Kaufman, Judith Parsells Kelly, David Babaian, Mary Banks
Proposals for research concerning fetal and/or placental tissue may be refused institutional review board (IRB) review, effectively preventing the research from occurring. We conducted an anonymous electronic survey of IRB chairs to determine their assessment of the likely response to research projects using fetal/placental tissue obtained from various procedures. We found that proposals concerning tissue obtained from diagnostic procedures or miscarriage were anticipated to be considered at most institutions...
May 1, 2017: Journal of Empirical Research on Human Research Ethics: JERHRE
https://www.readbyqxmd.com/read/28534070/total-abdominal-colectomy-vs-restorative-total-proctocolectomy-as-the-initial-approach-to-medically-refractory-ulcerative-colitis
#4
Jinyu Gu, Luca Stocchi, Jeanie Ashburn, Feza H Remzi
PURPOSE: There is scant data assessing the consequences of staging restorative proctocolectomy for ulcerative colitis. The aim of the study is to compare outcomes of initial vs. staged restorative proctocolectomy. METHODS: Patients completing restorative proctocolectomy, including ileostomy reversal, during 2006-2012 were identified from an IRB-approved database. Demographics, treatment variables, and perioperative outcomes were assessed. RESULTS: Out of 521 patients, 322 (62%) underwent initial total abdominal colectomy before restorative proctectomy...
May 22, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28532766/morcellation-efficiency-in-holmium-laser-enucleation-of-the-prostate-oscillating-morcellator-outperforms-reciprocating-morcellator-with-no-apparent-learning-curve
#5
Sean McAdams, Rafael Nunez-Nateras, Christopher J Martin, Stephen Cha, Mitchell R Humphreys
OBJECTIVE: To compare the morcellation efficiency of the Wolf® Piranha™ oscillating morcellator to the Lumenis® VersaCut™ reciprocating morcellator. METHODS: After IRB approval, we conducted a retrospective analysis of patients undergoing HoLEP for symptomatic benign prostatic hyperplasia. The first 41 cases of HoLEP with morcellation performed with the oscillating morcellator were matched by weight of resected tissue to 41 control patients from our historic data set that underwent morcellation with the reciprocating system...
May 19, 2017: Urology
https://www.readbyqxmd.com/read/28532732/nurses-health-promoting-lifestyle-behaviors-in-a-community-hospital
#6
Emma Kurnat-Thoma, Majeda El-Banna, Monica Oakcrum, Jill Tyroler
PURPOSE: To examine nurses' health-promoting lifestyle behaviors, describe their self-reported engagement in employee wellness program benefit options, and explore relationships between nurse demographic factors, health characteristics and lifestyle behaviors. BACKGROUND: Nurses adopting unhealthy lifestyle behaviors are at significantly higher risk for developing a number of chronic diseases and are at increased susceptibility to exhaustion, job dissatisfaction and turnover...
June 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28528267/using-mri-to-non-invasively-and-accurately-quantify-preoperative-hepatic-steatosis
#7
Callisia N Clarke, Haesun Choi, Ping Hou, Catherine H Davis, Jingfei Ma, Asif Rashid, Jean-Nicolas Vauthey, Thomas A Aloia
BACKGROUND: The obesity epidemic has significantly increased the incidence and severity of hepatic steatosis in liver surgery patients and liver donors, potentially impacting postoperative liver regeneration and function. Development of a non-invasive means to quantify hepatic steatosis would facilitate selection of candidates for liver resection and transplant donation. METHODS: An IRB-approved protocol prospectively enrolled 28 patients with liver tumors requiring hepatic resection...
May 17, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28525924/institutional-review-board-training-when-patients-and-community-members-are-engaged-as-researchers
#8
John M Westfall, Linda Zittleman, Maret Felzien, Marc Ringel, Alison Lakin, Don Nease
Background.: Patient engagement efforts often rely on a participatory research approach, which means engaging patients and community members in all aspects of research. As research team members, they require familiarity with the principles of human subject protection, privacy, and institutional review boards (IRB). However, the time required for individual IRB training may be a barrier to engaging community members in participatory research. As more community members participated in research, the State Networks of Colorado Practices and Partners (SNOCAP) was faced with finding a balance between including community members as part of the research team and the significant time commitment and institutional requirements for human subjects research oversight...
June 1, 2017: Family Practice
https://www.readbyqxmd.com/read/28525467/analysis-of-cervical-angiograms-in-cervical-spine-trauma-patients-does-it-make-a-difference
#9
Tina Dreger, Howard Place, Theresa Mattingly, Christine Piper, Jennifer Brechbuehler
STUDY DESIGN: Retrospective review. OBJECTIVE: To evaluate computed tomography angiogram (CTA) use for diagnosing blunt vertebral artery injury (BVAI) at a single institution, to assess the incidence of BVAI in the studied population, and determine if diagnosis affected care. We also wanted to evaluate if testing and treatment resulted in complications. SUMMARY OF BACKGROUND DATA: BVAI is an example of a previously underdiagnosed injury. Ease of CTA has simplified vertebral artery evaluation...
June 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28522112/diffuse-parenchymal-lung-disease-on-chest-radiographs-and-ct
#10
Theodore J Dubinsky, Hardik Shah, Rachelle Sonneborn, Daniel S Hippe
BACKGROUND: We prospectively identified B-lines in patients undergoing ultrasound examinations following liver transplants who also had a chest x-ray (CXR) and/or chest CT scan on the same day to determine if an association between the presence of B-lines s from the thorax on ultrasound images correlates with the presence of pulmonary abnormalities on chest radiographs. MATERIALS AND METHODS: Following IRB approval, patients undergoing routine postoperative liver transplant ultrasound examinations and a CXR and/or CT scan on the same day between 1/1/2015 through 7/1/2016 were prospectively identified...
May 15, 2017: Chest
https://www.readbyqxmd.com/read/28520679/knee-recurvatum-in-children-with-spastic-diplegic-cerebral-palsy
#11
Jeremy Bauer, K Patrick Do, Jing Feng, Rosemary Pierce, Michael Aiona
BACKGROUND: The purpose of this study is to determine which factors drive patients with diplegic cerebral palsy to walk without knee recurvatum despite hyperextension of the knee on physical examination. METHODS: A retrospective review was conducted of all data collected in the Gait Analysis Laboratory between 1999 and 2014. Patients with spastic diplegic cerebral palsy and at least 5 degrees of knee extension on clinical examination were identified for the study...
May 17, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28511996/comparative-characteristics-of-spermatozoa-harvested-and-cryopreserved-in-culture-and-cryoprotectant-media-with-or-without-donor-serum-proteins
#12
Ghofraan A Ata'Allah, Noor Azmi Mat Adenan, Nuguelis Razali, Kannappan Palaniappan, Rosliza Saad, Siti Khadijah Idris, Krishnan Kanniah, Jaffar Ali
The objectives of this study is to evaluate the efficacy of protein-free media in the preparation, holding and crypreservation of spermatazoa for use in ART. Normozoospermic semen samples (N=71) were used to compare the effects of media on the survival and quality of spermatozoa when washed and cultured with different media with and without added proteins at 4°C, 15°C, 22°C and 37°C for 0, 4-7 and 24h. Survival and quality of spermatozoa were assessed after freeze-thaw with synthetic cryoprotectant with and without proteins...
May 13, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/28509853/predictors-of-caregiver-burden-among-mothers-of-children-with-chronic-conditions
#13
Karina Javalkar, Eniko Rak, Alexandra Phillips, Cara Haberman, Maria Ferris, Miranda Van Tilburg
OBJECTIVE: The complex medical regimens of children and adolescents with chronic conditions can have a significant impact on families and households. Caregivers may experience burden, which can lead to negative health consequences and poor quality of life. The objective of this study was to determine child-related predictors and risk factors for caregiver burden among parents of children with chronic conditions. METHODS: We distributed an institutional review board (IRB)-approved, online cross-sectional survey to parents of children who attended the Victory Junction therapeutic camp...
May 16, 2017: Children
https://www.readbyqxmd.com/read/28509616/depersonalization-adversity-emotionality-and-coping-with-stressful-situations
#14
Paula Thomson, S Victoria Jaque
Depersonalization is defined as persistent or recurrent episodes of feeling detached or estranged from a sense of self and the world. This study addressed the primary question: Do non-clinical individuals who endorse high symptomatic depersonalization have inherently more intense emotional responses, along with more childhood adversity and past trauma? In this IRB approved study, participants who met clinical levels of depersonalization (n = 43, 16.3%) were compared to a group without clinical levels of depersonalization (n = 221, 83...
May 16, 2017: Journal of Trauma & Dissociation
https://www.readbyqxmd.com/read/28500923/history-injury-and-psychosocial-risk-factor-commonalities-among-cases-of-fatal-and-near-fatal-physical-child-abuse
#15
Mary Clyde Pierce, Kim Kaczor, Deborah Acker, Tina Webb, Allen Brenzel, Douglas J Lorenz, Audrey Young, Richard Thompson
Failure to recognize child maltreatment results in chronic exposure to high-risk environments where re-injury or death may occur. We analyzed a series (n=20) of fatal (n=10) and near-fatal (n=10) physical child abuse cases from the Commonwealth of Kentucky to identify commonalities and determine whether indicators of maltreatment were present prior to the child's fatal or near-fatal event. We conducted retrospective state record reviews involving children <4years of age classified as physical child abuse by the Cabinet for Health and Family Services during a 12 month period...
May 10, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28499250/redox-regulation-of-micrornas-in-endometriosis-associated-pain
#16
Kristeena Ray Wright, Brenda Mitchell, Nalini Santanam
Endometriosis is a chronic, painful condition with unknown etiology. A differential expression of microRNAs in the endometriotic tissues from women with endometriosis with pain compared to those without suggested a plausible role for miRNA or epigenetic mechanisms in the etiology of endometriotic pain. The peritoneal milieu is involved in maintenance of endometriotic lesion and nociception. We recently showed the mechanistic role for oxidized-lipoproteins (ox-LDLs) present in peritoneal fluid (PF) in endometriosis and pain...
May 4, 2017: Redox Biology
https://www.readbyqxmd.com/read/28494089/evaluation-of-the-tumor-registration-error-in-biopsy-procedures-performed-under-real-time-pet-ct-guidance
#17
Louise M Fanchon, Adytia Apte, C Ross Schmidtlein, Ellen Yorke, Yu-Chi Hu, Snjezana Dogan, Mathieu Hatt, Dimitris Visvikis, John L Humm, Stephen B Solomon, Assen S Kirov
PURPOSE: The purpose of this study is to quantify tumor displacement during real-time PET/CT guided biopsy and to investigate correlations between tumor displacement and false-negative results. METHODS: 19 patients who underwent real-time (18) F-FDG PET-guided biopsy and were found positive for malignancy were included in this study under IRB approval. PET/CT images were acquired for all patients within minute prior biopsy to visualize the FDG-avid region and plan the needle insertion...
May 11, 2017: Medical Physics
https://www.readbyqxmd.com/read/28487159/recruitment-failure-and-futility-were-the-most-common-reasons-for-discontinuation-of-clinical-drug-trials-results-of-a-nationwide-inception-cohort-study-in-the-netherlands
#18
Cornelis A van den Bogert, Patrick C Souverein, Cecile T M Brekelmans, Susan W J Janssen, Gerard H Koëter, Hubert G M Leufkens, Lex M Bouter
OBJECTIVE: To identify the reasons for discontinuation of clinical drug trials and to evaluate whether efficacy-related discontinuations were adequately planned in the trial protocol. STUDY DESIGN AND SETTING: All clinical drug trials in the Netherlands, reviewed by Institutional Review Boards (IRBs) in 2007, were followed until December 2015. Data were obtained through the database of the Dutch competent authority (CCMO) and a questionnaire to the principal investigators...
May 6, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28483228/clinical-manifestations-of-neuroblastoma-with-head-and-neck-involvement-in-children
#19
Sameer Alvi, Omar Karadaghy, Michelle Manalang, Robert Weatherly
OBJECTIVE: The purpose of our study is to review our 15-year experience with pediatric patients who have been diagnosed with neuroblastoma, and to determine their most frequent head and neck manifestations and symptoms. STUDY DESIGN: Retrospective chart review of electronic medical record. SETTING: An academic, tertiary care pediatric hospital. SUBJECTS AND METHODS: IRB approval from the Office of Research Integrity at Children's Mercy Hospital was obtained...
June 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28482827/mucin-1-a-signal-transduction-membrane-bound-mucin-is-present-in-human-disc-tissue-and-is-downregulated-in-vitro-by-exposure-to-il-1%C3%A3-or-tnf-%C3%AE
#20
Helen E Gruber, Jane A Ingram, Gretchen L Hoelscher, Emilio Marrero, Edward N Hanley
BACKGROUND: Back pain and disc degeneration have a growing socioeconomic healthcare impact. Mucin 1 (MUC1) is a transmembrane glycoprotein whose extracellular and intracellular domains participate in cellular signaling. Little is currently known about the presence or role of MUC1 in human disc degeneration. METHODS: In this IRB-approved research study, 29 human disc specimens were analyzed for MUC1 immunohistochemical localization and gene expression, and annulus fibrosus (annulus) cells were also isolated and cultured in 3D...
May 8, 2017: BMC Musculoskeletal Disorders
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