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Joel Kaluzny, Hao Li, Wenzhong Liu, Peter Nesper, Justin Park, Hao F Zhang, Amani A Fawzi
PURPOSE: To demonstrate the versatility and performance of a compact Bayer filter snapshot hyperspectral fundus camera for in-vivo clinical applications including retinal oximetry and macular pigment optical density measurements. METHODS: 12 healthy volunteers were recruited under an Institutional Review Board (IRB) approved protocol. Fundus images were taken with a custom hyperspectral camera with a spectral range of 460-630 nm. We determined retinal vascular oxygen saturation (sO2) for the healthy population using the captured spectra by least squares curve fitting...
October 21, 2016: Current Eye Research
M J Lin, F Baky, B C Housley, N Kelly, E Pletcher, J D Balshi, S P Stawicki, D C Evans
INTRODUCTION: Clinical information continues to be limited regarding changes in the temporal risk profile for readmissions during the initial postoperative year in vascular surgery patients. We set out to describe the associations between demographics, clinical outcomes, comorbidity indices, and hospital readmissions in a sample of patients undergoing common extremity revascularization or dialysis access (ERDA) procedures. We hypothesized that factors independently associated with readmission will evolve from "short-term" to "long-term" determinants at 30-, 180-, and 360-day postoperative cutoff points...
October 2016: Journal of Postgraduate Medicine
Melinda Wolboldt, Barbara Saltzman, Patrick Tenbrink, Khaled Shahrour, Samay Jain
INTRODUCTION: With healthcare reform, cost and patient satisfaction will directly affect hospital reimbursement. We present data on same day discharge (SDD) for patients who underwent robot assisted laparoscopic radical prostatectomy (RALP). METHODS: Patient data were gathered in an IRB approved database. In April 2015, surgeon (SJ) began SDD. The SDD protocol for RALP includes multimodal anesthesia/analgesia and extended recovery. Interim analysis revealed that government insurance (CMS) refused hospital reimbursement for SDD...
October 19, 2016: Journal of Endourology
Jason R Kovac, Ryan P Smith, Miguel Cajipe, Dolores J Lamb, Larry I Lipshultz
In couples with infertility, abnormal strict morphology of 0% normal forms (NF) is a criterion to proceed rapidly to in vitro fertilization (IVF). Since no data currently exist, we investigated the outcomes for men with 0% NF to determine reproductive success without the use of assisted reproductive technologies (ART). A cohort of 24 men with 0% NF were identified (2010-2013) with 27 randomly selected men with ≥4% NF as controls. Patient charts were reviewed with men contacted and administered an Institutional Review Board (IRB)-approved telephone questionnaire to ascertain outcomes...
September 30, 2016: Asian Journal of Andrology
Raquel Rose Silva Correia, Jean Remy Davée Guimarães
Recent studies have shown Hg methylation in mangrove sediments, however, little is known about the different microorganism consortia involved. We investigated the participation of prokaryotes in general, iron-reducing bacteria-IRB, sulfate-reducing bacteria-SRB, methanogens and fungi in Hg methylation and sulfate reduction rates (SRR) in mangrove sediments using iron amendments for IRB and specific inhibitors for the other microorganisms. Sediment samples were collected from two mangrove zones, tidal flat and mangrove forest (named root sediments)...
October 14, 2016: Chemosphere
Rebecca D Blanchard, Stephen DeMeo, Alisa Nagler
No abstract text is available yet for this article.
October 4, 2016: Academic Medicine: Journal of the Association of American Medical Colleges
Abdullah Alzaid, Samuel A M Martin, Daniel J Macqueen
The insulin-like growth factor (IGF) receptor (IGF-IR) is necessary for IGF signalling and has essential roles in cellular growth. In teleost fish, two distinct IGF-IR duplicates are conserved called IGF-IRa and IGF-IRb. However, while a salmonid-specific whole genome duplication (ssWGD) is known to have expanded several key genes within the IGF axis, its impact on the IGF-IR repertoire remains unresolved. Using bioinformatic and phylogenetic approaches, we establish that salmonids retain two IGF-IRa paralogues from ssWGD and a single IGF-IRb copy...
October 17, 2016: Scientific Reports
Bernard Gallagher, Anne H Berman, Justyna Bieganski, Adele D Jones, Liliana Foca, Ben Raikes, Johanna Schiratzki, Mirjam Urban, Sara Ullman
Although international research is increasing in volume and importance, there remains a dearth of knowledge on similarities and differences in "national human research ethics" (NHREs), that is, national ethical guidelines (NEGs), Institutional Review Boards (IRBs), and research stakeholder' ethical attitudes and behaviors (EABs). We begin to address this situation by reporting upon our experiences in conducting a multinational study into the mental health of children who had a parent/carer in prison. The study was conducted in 4 countries: Germany, Great Britain, Romania, and Sweden...
October 2, 2016: Ethics & Behavior
Pamela S Hinton, Peggy Nigh, John Thyfault
PURPOSE: We previously reported that 12months of resistance training (RT, 2×/wk, N=19) or jump training (JUMP, 3×/wk, N=19) increased whole body and lumbar spine BMD and increased serum bone formation markers relative to resorption in physically active (≥4h/wk) men (mean age: 44±2y; median: 44y) with osteopenia of the hip or spine. The purpose of this secondary analysis was to examine the effects of the RT or JUMP intervention on potential endocrine mediators of the exercise effects on bone, specifically IGF-I, PTH and sclerostin...
October 12, 2016: Bone
Connie Y Chang, Susan V Kattapuram, Ambrose J Huang, F Joseph Simeone, Martin Torriani, Miriam A Bredella
OBJECTIVES: To determine the efficacy and safety of percutaneous calcitonin and steroid injection in the treatment of aneurysmal bone cysts (ABCs). MATERIALS AND METHODS: Our study was IRB-approved and HIPAA-compliant. We reviewed pre- and post-procedural imaging studies and medical records of all CT-guided percutaneous injections of ABCs with calcitonin and steroid performed at our institution between 2003 and 2015. RESULTS: Treatment success based on imaging was categorized as substantial (51-100 %), partial (1-50 %), or none (0 %) by comparing radiographs of the lesion before and after treatment...
October 14, 2016: Skeletal Radiology
Erhan Gökçek, Ayhan Kaydu, Mehmet Salim Akdemir, Ferit Akil, Ibrahim Ozkan Akıncı
PURPOSE: To compared the effects of sevoflurane and desflurane on early anesthesia recovery in patients undergoing to craniotomy for intracranial lesions. METHODS: After IRB approval, the study included 50 patients aged 18-70 years who had ASA physical statuses of I-II and were scheduled for intracranial surgery. Patients were randomly divided into two groups: sevoflurane and desflurane. Anaesthesia was routinely induced in all patients followed by desflurane 5%-6% or sevoflurane 1%-2%...
September 2016: Acta Cirúrgica Brasileira
Alvin Rajkomar, Sneha Lingam, Andrew G Taylor, Michael Blum, John Mongan
The study aimed to determine if computer vision techniques rooted in deep learning can use a small set of radiographs to perform clinically relevant image classification with high fidelity. One thousand eight hundred eighty-five chest radiographs on 909 patients obtained between January 2013 and July 2015 at our institution were retrieved and anonymized. The source images were manually annotated as frontal or lateral and randomly divided into training, validation, and test sets. Training and validation sets were augmented to over 150,000 images using standard image manipulations...
October 11, 2016: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
Shanshan Bao, Jonathan I Tamir, Jeffrey L Young, Umar Tariq, Martin Uecker, Peng Lai, Weitian Chen, Michael Lustig, Shreyas S Vasanawala
PURPOSE: To develop and clinically evaluate a pediatric knee magnetic resonance imaging (MRI) technique based on volumetric fast spin-echo (3DFSE) and compare its diagnostic performance, image quality, and imaging time to that of a conventional 2D protocol. MATERIALS AND METHODS: A 3DFSE sequence was modified and combined with a compressed sensing-based reconstruction resolving multiple image contrasts, a technique termed T2 Shuffling (T2 Sh). With Institutional Review Board (IRB) approval, 28 consecutive children referred for 3T knee MRI prospectively underwent a standard clinical knee protocol followed by T2 Sh...
October 11, 2016: Journal of Magnetic Resonance Imaging: JMRI
Clara Park, Tatjana Gruber-Rouh, Doris Leithner, Amelie Zierden, Mortiz H Albrecht, Julian L Wichmann, Boris Bodelle, Mohamed Elsabaie, Jan-Erik Scholtz, Moritz Kaup, Thomas J Vogl, Martin Beeres
BACKGROUND: Evaluation of latest generation automated attenuation-based tube potential selection (ATPS) impact on image quality and radiation dose in contrast-enhanced chest-abdomen-pelvis computed tomography examinations for gynaecologic cancer staging. METHODS: This IRB approved single-centre, observer-blinded retrospective study with a waiver for informed consent included a total of 100 patients with contrast-enhanced chest-abdomen-pelvis CT for gynaecologic cancer staging...
October 10, 2016: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
Caitlin E Rancher, Jody M Shoemaker, Linda E Petree, Mark Holdsworth, John P Phillips, Deborah L Helitzer
BACKGROUND: Returning neuroimaging incidental findings (IF) may create a challenge to research participants' health literacy skills as they must interpret and make appropriate healthcare decisions based on complex radiology jargon. Disclosing IF can therefore present difficulties for participants, research institutions and the healthcare system. The purpose of this study was to identify the extent of the health literacy challenges encountered when returning neuroimaging IF. We report on findings from a retrospective survey and focus group sessions with major stakeholders involved in disclosing IF...
October 11, 2016: BMC Medical Ethics
Tobin J Strom, Arash O Naghavi, Andy M Trotti, Jeffery Russell, Julie A Kish, Judith McCaffrey, Kristen J Otto, Louis B Harrison, Jimmy J Caudell
PURPOSE: Concurrent chemoradiotherapy (CRT) is the standard of care for many sites of locally advanced head and neck squamous cell carcinomas (LAHNC). However, on meta-analysis, the addition of chemotherapy did not improve survival for patients >70years. We hypothesized that elderly patients treated with CRT would have increased toxicity without similar improvements in survival. METHODS: A single-institution, IRB-approved retrospective study took place from 2005 to 2012 including 369 patients treated with CRT for LAHNC...
October 3, 2016: Journal of Geriatric Oncology
Eleonora Horvath, Claudio F Silva, Sergio Majlis, Ignacio Rodriguez, Velimir Skoknic, Alex Castro, Hugo Rojas, Juan-Pablo Niedmann, Arturo Madrid, Felipe Capdeville, Carolina Whittle, Ricardo Rossi, Miguel Domínguez, Hernán Tala
OBJECTIVE: To assess performance of TIRADS classification on a prospective surgical cohort, demonstrating its clinical usefulness. METHODS: Between June 2009 and October 2012, patients assessed with pre-operative ultrasound (US) were included in this IRB-approved study. Nodules were categorised according to our previously described TIRADS classification. Final pathological diagnosis was obtained from the thyroidectomy specimen. Sensitivity, specificity, positive/negative predictive values and likelihood ratios were calculated...
October 7, 2016: European Radiology
Saurabh Singhal, Aparna Kailasam, Shunsuke Akimoto, Takahiro Masuda, Carrie Bertellotti, Sumeet K Mittal
BACKGROUND: Advent of minimally-invasive esophagectomy necessitated the incorporation of stapled anastomotic techniques especially for intrathoracic anastomosis. We present our approach to the Ivor Lewis esophagectomy highlighting a simple modification in the anastomotic technique and review our experience with anastomotic outcomes. METHODS: With IRB approval, patients who underwent Ivor Lewis esophagectomy with circular-stapled end-to-end anastomosis (EEA) were identified, divided into three equal sequential cohorts (A, B, and C), and compared for perioperative outcome...
October 5, 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Felix P Kuhn, Georg Spinner, Filippo Del Grande, Michael Wyss, Marco Piccirelli, Stefan Erni, Pascal Pfister, Michael Ho, Bert-Ram Sah, Lukas Filli, Dominik A Ettlin, Luigi M Gallo, Gustav Andreisek, Andrei Manoliu
OBJECTIVES: To qualitatively and quantitatively compare MR imaging of the temporomandibular joint (TMJ) at 7.0 T using high-permittivity dielectric pads and 3.0 T using a clinical high-resolution protocol. METHODS: IRB approved study with written informed consent. 12 asymptomatic volunteers were imaged at 7.0T and 3.0T using 32-channel head coils. High-permittivity dielectric pads consisting of barium titanate in deuterated suspension were used for imaging at 7...
October 5, 2016: Dento Maxillo Facial Radiology
Stephen M Modell
No abstract text is available yet for this article.
October 4, 2016: Journal of Religion and Health
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