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https://www.readbyqxmd.com/read/28544851/low-ceiling-temperature-polymer-microcapsules-with-hydrophobic-payloads-via-rapid-emulsion-solvent-evaporation
#1
Shijia Tang, Mostafa Yourdkhani, Catherine M Possanza Casey, Nancy R Sottos, Scott R White, Jeffrey S Moore
We report a microencapsulation procedure based on rapid solvent evaporation to prepare microcapsules with hydrophobic core materials and low ceiling temperature polymer shell wall of cyclic poly(phthalaldehyde) (cPPA). We use and compare microfluidic and bulk emulsions. In both methods, rapid solvent evaporation following emulsification resulted in kinetically trapped core-shell microcapsules while slow evaporation resulted in acorn morphology. Through the systematic variation of encapsulation parameters, we found that polymer-to-core weight ratios higher than 1 and polymer concentration higher than 4...
May 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28544592/direct-influence-of-titanium-and-zirconia-particles-on-the-morphology-and-functionality-of-mature-human-osteoclasts
#2
Juliane Pasold, Jana Markhoff, Jenny Tillmann, Martin Krogull, Phillip Pisowocki, Rainer Bader
Within the last ten years of biomedical implants, the focus is increasingly on bioceramics, specifically on zirconia (ZrO2 ). Hence, we analyzed the impact of zirconia particles in comparison to titanium (cpTi) particles on mature human osteoclasts (OCs) as little is known about the direct effect of wear particles on mature OCs and their role in the osteolytic process during aseptic endoprosthesis loosening. Changes in cell morphology and functionality of OCs incubated with particles in different concentrations were investigated...
May 22, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28544030/trapping-a-silicon-i-radical-with-carbenes-a-cationic-caac-silicon-i-radical-and-an-nhc-parent-silyliumylidene-cation
#3
Yan Li, Yuk-Chi Chan, Bi-Xiang Leong, Yongxin Li, Emma Richards, Indu Purushothaman, Susmita De, Pattiyil Parameswaran, Cheuk-Wai So
The trapping of a silicon(I) radical with N-heterocyclic carbenes is described. The reaction of the cyclic (alkyl)(amino) carbene [cAACMe ] (cAACMe =:C(CMe2 )2 (CH2 )NAr, Ar=2,6-iPr2 C6 H3 ) with H2 SiI2 in a 3:1 molar ratio in DME afforded a mixture of the separated ion pair [(cAACMe )2 Si:(.) ](+) I(-) (1), which features a cationic cAAC-silicon(I) radical, and [cAACMe -H](+) I(-) . In addition, the reaction of the NHC-iodosilicon(I) dimer [IAr (I)Si:]2 (IAr =:C{N(Ar)CH}2 ) with 4 equiv of IMe (:C{N(Me)CMe}2 ), which proceeded through the formation of a silicon(I) radical intermediate, afforded [(IMe )2 SiH](+) I(-) (2) comprising the first NHC-parent-silyliumylidene cation...
May 24, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28543610/metallic-nanoparticles-irradiated-by-low-energy-protons-for-radiation-therapy-are-there-significant-physical-effects-to-enhance-the-dose-delivery
#4
Anne-Catherine Heuskin, Bernard Gallez, Olivier Feron, Philippe Martinive, Carine Michiels, Stéphane Lucas
PURPOSE: To identify which physical properties of nanoparticles are correlated to the survival fraction of cells exposed in vitro to low energy protons in combination with nanoparticles. METHODS: The Geant4 simulation toolkit (version 10.3) was used to model nanoparticles of different sizes (5 to 50 nm) and materials (Ti, Zr, Hf, Ta, Au, Pt), with or without an organic capping ensuring biocompatibility and to irradiate them with 1.3 or 4 MeV protons and 5.3 MeV alpha particles...
May 23, 2017: Medical Physics
https://www.readbyqxmd.com/read/28542335/interventions-that-effectively-target-anopheles-funestus-mosquitoes-could-significantly-improve-control-of-persistent-malaria-transmission-in-south-eastern-tanzania
#5
Emmanuel W Kaindoa, Nancy S Matowo, Halfan S Ngowo, Gustav Mkandawile, Arnold Mmbando, Marcelina Finda, Fredros O Okumu
Malaria is transmitted by many Anopheles species whose proportionate contributions vary across settings. We re-assessed the roles of Anopheles arabiensis and Anopheles funestus, and examined potential benefits of species-specific interventions in an area in south-eastern Tanzania, where malaria transmission persists, four years after mass distribution of long-lasting insecticide-treated nets (LLINs). Monthly mosquito sampling was done in randomly selected households in three villages using CDC light traps and back-pack aspirators, between January-2015 and January-2016, four years after the last mass distribution of LLINs in 2011...
2017: PloS One
https://www.readbyqxmd.com/read/28541568/effect-of-feeding-history-and-time-elapsed-from-field-collection-on-the-movement-behavior-and-response-to-stimulation-in-cimex-lectularius-hemiptera-cimicidae
#6
Desen Wang, Changlu Wang, Narinderpal Singh, Amanda L Eiden, Richard Cooper, Chen Zha
The common bed bug (Cimex lectularius L.) (Hemiptera: Cimicidae) is an obligate blood-sucking insect that has been resurging in many countries. Researching this pest's behavior will help design more effective control methods. In this study, we evaluated the effect of feeding history and time elapsed from field collection on bed bug movement behavior and response to chemical lure or carbon dioxide stimulation in the laboratory. After CO2 was released, bed bugs unfed for 3 d began to return to harborages; in contrast, the ones unfed for 2 and 4 wk spent significantly more time outside their harborages during the first 1 h after than the 1 h before CO2 release...
May 25, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28541523/attraction-of-the-euwallacea-sp-near-fornicatus-coleoptera-curculionidae-to-quercivorol-and-to-infestations-in-avocado
#7
John A Byers, Yonatan Maoz, Anat Levi-Zada
The Euwallacea sp. near fornicatus (Euwallacea sp. 1 hereafter) feeds on many woody shrubs and trees and is a pest of avocado, Persea americana Mill., in several countries including Israel and the United States. Quercivorol baits are commercially available for Euwallacea sp. 1 females (males do not fly), but their attractive strength compared to other pheromones and potential for mass trapping are unknown. We used sticky traps baited with quercivorol released at 0.126 mg/d (1×) and at 0.01×, 0.1×, and 10× relative rates to obtain a dose-response curve of Euwallacea sp...
May 24, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28539445/structure-of-simian-immunodeficiency-virus-envelope-spikes-bound-with-cd4-and-monoclonal-antibody-36d5
#8
Guiqing Hu, Jun Liu, Kenneth H Roux, Kenneth A Taylor
The HIV-1/SIV envelope spike (Env) mediates the viral entry into host cells. The V3 loop of the gp120 component of the Env trimer contributes to the co-receptor binding site and is a target for neutralizing antibodies. We have used cryoelectron tomography to visualize the binding of CD4 and the V3 loop monoclonal antibody 36D5 to gp120 of the SIV Env. Our results show that 36D5 binds gp120 at the base of the V3 loop and suggest the antibody exerts its neutralization effect by blocking the co-receptor binding site...
May 24, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28536823/efficacy-and-safety-of-anakinra-in-tumor-necrosis-factor-receptor-associated-periodic-syndrome-traps-complicated-by-severe-renal-failure-a-report-after-long-term-follow-up-and-review-of-the-literature
#9
REVIEW
Stefano Gentileschi, Donato Rigante, Antonio Vitale, Jurgen Sota, Bruno Frediani, Mauro Galeazzi, Luca Cantarini
Tumor necrosis factor receptor-associated periodic syndrome (TRAPS), caused by mutations in the TNFRSF1A gene, is the most frequent autosomal dominant autonflammatory disease displaying a relevant risk of reactive AA amyloidosis, if left untreated. Our report deals with one adult with TRAPS complicated by amyloidosis-related renal failure, treated with the recombinant human interleukin-1 receptor antagonist anakinra at a higher than conventional dosage. This treatment did not present any adverse event and led remarkably to the disappearance of all TRAPS-related manifestations and prompt decrease of laboratory abnormalities, including proteinuria...
May 23, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28536276/persistent-immune-stimulation-exacerbates-genetically-driven-myeloproliferative-disorders-via-stromal-remodeling
#10
Claudio Tripodo, Alessia Burocchi, Pier Paolo Piccaluga, Claudia Chiodoni, Paola Portararo, Barbara Cappetti, Laura Botti, Alessandro Gulino, Alessandro Isidori, Arcangelo Liso, Giuseppe Visani, Maria Paola Martelli, Brunangelo Falini, Pier Paolo Pandolfi, Mario P Colombo, Sabina Sangaletti
Systemic immune stimulation has been associated with increased risk of myeloid malignancies, but the pathogenic link is unknown. We demonstrate in animal models that experimental systemic immune activation alters the bone marrow stromal microenvironment, disarranging extracellular matrix (ECM) microarchitecture, with down-regulation of SPARC and collagen-I and induction of complement activation. These changes were accompanied by a decrease in Treg frequency and by an increase in activated effector T cells. Under these conditions, hematopoietic precursors harboring nucleophosmin-1 (NPM1) mutation generated myeloid cells unfit for normal hematopoiesis but prone to immunogenic death, leading to neutrophil extracellular trap (NET) formation...
May 23, 2017: Cancer Research
https://www.readbyqxmd.com/read/28535934/validated-high-performance-anion-exchange-chromatography-with-pulsed-amperometric-detection-method-for-the-determination-of-residual-keratan-sulfate-and-other-glucosamine-impurities-in-sodium-chondroitin-sulfate
#11
Susanna Bottelli, Gianluca Grillo, Edoardo Barindelli, Alessandro Nencioni, Alessandro Di Maria, Tiziano Fossati
An efficient and sensitive analytical method based on high-performance anion exchange chromatography with pulsed amperometric detection (HPAEC-PAD) was devised for the determination of glucosamine (GlcN) in sodium chondroitin sulfate (CS). Glucosamine (GlcN) is intended as marker of residual keratan sulfate (KS) and other impurities generating glucosamine by acidic hydrolyzation. The latter brings CS and KS to their respective monomers. Since GlcN is present only in KS we developed a method that separates GlcN from GalN, the principal hydrolytic product of CS, and then we validated it in order to quantify GlcN...
May 10, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28535880/development-and-validation-of-a-novel-quantification-approach-for-gradient-elution-reversed-phase-high-performance-liquid-chromatography-coupled-to-tandem-icp-mass-spectrometry-rp-hplc-icp-ms-ms-and-its-application-to-diclofenac-and-its-related-compounds
#12
Balázs Klencsár, Lieve Balcaen, Filip Cuyckens, Frédéric Lynen, Frank Vanhaecke
A novel quantification approach, compensating for the effect of gradient elution on the instrumental response during reversed phase high-performance liquid chromatography - inductively coupled plasma - tandem mass spectrometry analysis, has been developed and validated. As a proof of concept, diclofenac and its related compounds, including its major metabolite i.e. 4'-hydroxy-diclofenac, have been quantitatively determined in human plasma matrix. An inductively coupled plasma - tandem mass spectrometer has been applied for the interference-free determination of Cl as (35)ClH2(+) using H2 as a reaction gas in the collision/reaction cell...
June 29, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28535663/up-regulation-of-rank-expression-via-erk1-2-by-insulin-contributes-to-the-enhancement-of-osteoclast-differentiation
#13
Ju Hee Oh, Na Kyung Lee
Despite the importance of the receptor activator of nuclear factor (NF)-kappaB ligand (RANKL)-RANK signaling mechanisms on osteoclast differentiation, little has been studied on how RANK expression is regulated or what regulates its expression during osteoclastogenesis. We show here that insulin signaling increases RANK expression, thus enhancing osteoclast differentiation by RANKL. Insulin stimulation induced RANK gene expression in time- and dose-dependent manners and insulin receptor shRNA completely abolished RANK expression induced by insulin in bone marrow-derived monocyte/ macrophage cells (BMMs)...
May 22, 2017: Molecules and Cells
https://www.readbyqxmd.com/read/28535008/how-much-medium-do-you-use-for-cell-culture-medium-volume-influences-mineralization-and-osteoclastogenesis-in%C3%A2-vitro
#14
Yoshitaka Yoshimura, Takashi Kikuiri, Tomokazu Hasegawa, Mino Matsuno, Hajime Minamikawa, Yoshiaki Deyama, Kuniaki Suzuki
Bone is maintained by a balance between bone formation and resorption. This remodeling is controlled by a wide variety of systemic and local factors including hormones, cytokines and mechanical stresses. The present in vitro study examined the impact of medium volume, using 0.4, 0.6, 0.8, 1.0, 1.5 and 2.0 ml/well in a 24‑well plate, on the differentiation of osteoblasts and osteoclasts. There were no differences in the alkaline phosphatase activity of osteoblasts amongst the groups; however, the area of mineral deposition was decreased in a media volume‑dependent manner...
May 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28534573/solvent-dependent-nuclearity-geometry-and-catalytic-activity-of-sphos-pd-ph-cl-2
#15
John B Brazier, Mark A Newton, Elena M Barreiro, Luis A Adrio, Leticia Naya, King Kuok Mimi Hii
The nuclearity and structures of the palladium complex [(SPhos)Pd(Ph)Cl]2 in the solid and solution states are revisited using a combination of Extended X-ray Absorption Fine Structure (EXAFS) spectroscopy, NMR spectroscopy, mass spectrometry, DFT calculations and trapping experiments. The complex was tested for its catalytic activity in the coupling reaction between chlorobenzene and n-hexylamine, where different deactivation behaviours were observed in toluene, 1,4-dioxane and DMF.
May 23, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28533382/interplay-of-catalysis-fidelity-threading-and-processivity-in-the-exo-and-endonucleolytic-reactions-of-human-exonuclease-i
#16
Yuqian Shi, Homme W Hellinga, Lorena S Beese
Human exonuclease 1 (hExo1) is a member of the RAD2/XPG structure-specific 5'-nuclease superfamily. Its dominant, processive 5'-3' exonuclease and secondary 5'-flap endonuclease activities participate in various DNA repair, recombination, and replication processes. A single active site processes both recessed ends and 5'-flap substrates. By initiating enzyme reactions in crystals, we have trapped hExo1 reaction intermediates that reveal structures of these substrates before and after their exo- and endonucleolytic cleavage, as well as structures of uncleaved, unthreaded, and partially threaded 5' flaps...
May 22, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28533267/the-kv1-associated-molecules-tag-1-and-caspr2-are-selectively-targeted-to-axon-initial-segment-in-hippocampal-neurons
#17
Delphine Pinatel, Bruno Hivert, Margaux Saint-Martin, Nelly Noraz, Maria Savvaki, Domna Karagogeos, Catherine Faivre-Sarrailh
Caspr2 and TAG-1 are cell adhesion molecules (CAMs) associated with the voltage-gated potassium channels Kv1.1/1.2 at regions controlling axonal excitability, the axon initial segment (AIS) and juxtaparanodes of myelinated axons. The distribution of Kv1 at juxtaparanodes requires axo-glial contacts mediated by Caspr2 and TAG-1. In the present study, we showed that TAG-1 strongly co-localizes with Kv1.2 at the AIS of cultured hippocampal neurons whereas Caspr2 is uniformly expressed along the axolemma. Live-cell imaging revealed that Caspr2 and TAG-1 are sorted together in axonal transport vesicles...
May 22, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28532991/estimating-population-density-for-disease-risk-assessment-the-importance-of-understanding-the-area-of-influence-of-traps-using-wild-pigs-as-an-example
#18
Amy J Davis, Bruce Leland, Michael Bodenchuk, Kurt C VerCauteren, Kim M Pepin
Population density is a key driver of disease dynamics in wildlife populations. Accurate disease risk assessment and determination of management impacts on wildlife populations requires an ability to estimate population density alongside management actions. A common management technique for controlling wildlife populations to monitor and mitigate disease transmission risk is trapping (e.g., box traps, corral traps, drop nets). Although abundance can be estimated from trapping actions using a variety of analytical approaches, inference is limited by the spatial extent to which a trap attracts animals on the landscape...
June 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28530748/photomultiplication-type-narrowband-organic-photodetectors-working-at-forward-and-reverse-bias
#19
Jianli Miao, Fujun Zhang, Mingde Du, Wenbin Wang, Ying Fang
It is a great challenge to obtain narrowband and photomultiplication (PM) type organic photodetectors (OPDs) without optical filters due to the broad absorption range and large exciton binding energy of organic materials. Narrowband OPDs with the special structure of ITO/PFN-OX/P3HT : PC61BM (100 : 1,wt/wt)/Al were successfully fabricated with different active layer thicknesses, exhibiting a tunable response window and PM phenomenon under bi-directional bias. The OPDs exhibit U-shaped EQE spectra with two narrowband response windows under forward bias and a single narrowband response window under reverse bias...
May 22, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28527901/photonic-ring-resonance-is-a-versatile-platform-for-performing-multiplex-immunoassays-in-real-time
#20
Sasi Mudumba, Sophia de Alba, Randy Romero, Carli Cherwien, Alice Wu, Jue Wang, Martin A Gleeson, Muzammil Iqbal, Rufus W Burlingame
Photonic ring resonance is a property of light where in certain circumstances specific wavelengths are trapped in a ring resonator. Sensors based on silicon photonic ring resonators function by detecting the interaction between light circulating inside the sensor and matter deposited on the sensor surface. Binding of biological material results in a localized change in refractive index on the sensor surface, which affects the circulating optical field extending beyond the sensor boundary. That is, the resonant wavelength will change when the refractive index of the medium around the ring resonator changes...
May 17, 2017: Journal of Immunological Methods
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