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https://www.readbyqxmd.com/read/29334656/activated-protein-c-suppresses-osteoclast-differentiation-via-endothelial-protein-c-receptor-protease-activated-receptor-1-sphingosine-1-phosphate-receptor-and-apolipoprotein-e-receptor-2
#1
Kakunoshin Yoshida, Nobuyuki Akita, Takayuki Okamoto, Kunihiro Asanuma, Atsumasa Uchida, Akihiro Sudo, Motomu Shimaoka, Koji Suzuki, Tatsuya Hayashi
INTRODUCTION: Bone remodeling relies on a delicate balance between formation and resorption of bone tissues, processes in which bone-forming osteoblasts and bone-resorbing osteoclasts play central roles. Recently, we reported that anticoagulant activated protein C (APC) promotes osteoblast proliferation, but the role of the blood coagulation system in bone remodeling remains unclear. In this study, to further elucidate the relationship between bone remodeling and blood coagulation, we investigated the effect of APC on osteoclast differentiation...
January 3, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29333765/ultrathin-feooh-nanolayers-with-rich-oxygen-vacancies-on-bivo4-photoanodes-for-efficient-water-oxidation
#2
Yingpu Bi, Beibei Zhang, Lei Wang, Yajun Zhang, Yong Ding
Photoelectrochemical (PEC) water splitting is a promising method for storing solar energy in the form of hydrogen fuel, but greatly hindered by the sluggish kinetics of the oxygen evolution reaction (OER). Herein, a facile solution impregnation method is developed for growing highly crystalline β-FeOOH nanolayers with ultrathin thickness (2 nm) and abundant oxygen vacancies on BiVO4 photoanodes, which exhibited a remarkable photocurrent density of 4.3 mA cm-2 at 1.23 V (vs. reversible hydrogen electrode (RHE), AM 1...
January 14, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29332799/rapid-identification-of-regulated-organic-chemical-compounds-in-toys-using-ambient-ionization-and-a-miniature-mass-spectrometry-system
#3
Xiangyu Guo, Hua Bai, Yueguang Lv, Guangcheng Xi, Junfang Li, Xiaoxiao Ma, Yue Ren, Zheng Ouyang, Qiang Ma
Rapid, on-site analysis was achieved through significantly simplified operation procedures for a wide variety of toy samples (crayon, temporary tattoo sticker, finger paint, modeling clay, and bubble solution) using a miniature mass spectrometry system with ambient ionization capability. The labor-intensive analytical protocols involving sample workup and chemical separation, traditionally required for MS-based analysis, were replaced by direct sampling analysis using ambient ionization methods. A Mini β ion trap miniature mass spectrometer was coupled with versatile ambient ionization methods, e...
April 1, 2018: Talanta
https://www.readbyqxmd.com/read/29331635/sotatercept-with-long-term-extension-for-the-treatment-of-anaemia-in-patients-with-lower-risk-myelodysplastic-syndromes-a-phase-2-dose-ranging-trial
#4
Rami Komrokji, Guillermo Garcia-Manero, Lionel Ades, Thomas Prebet, David P Steensma, Joseph G Jurcic, Mikkael A Sekeres, Jesus Berdeja, Michael R Savona, Odile Beyne-Rauzy, Aspasia Stamatoullas, Amy E DeZern, Jacques Delaunay, Gautam Borthakur, Robert Rifkin, Thomas E Boyd, Abderrhamane Laadem, Bond Vo, Jennie Zhang, Marie Puccio-Pick, Kenneth M Attie, Pierre Fenaux, Alan F List
BACKGROUND: Myelodysplastic syndromes are characterised by ineffective erythropoiesis leading to anaemia. Sotatercept (ACE-011) is a novel activin receptor type IIA fusion protein that acts as a ligand trap to neutralise negative regulators of late-stage erythropoiesis. The aim of the study was to establish a safe and effective dose of sotatercept for the treatment of anaemia in patients with lower-risk myelodysplastic syndromes. METHODS: This open-label, multicentre, dose-ranging, phase 2 trial took place at 11 treatment centres in the USA and France...
January 10, 2018: Lancet Haematology
https://www.readbyqxmd.com/read/29331278/impact-of-treatment-with-a-protein-tyrosine-kinase-inhibitor-genistein-on-acute-and-chronic-experimental-schistosoma-mansoni-infection
#5
Maysa Mohamed Kamel Sobhy, Soheir Sayed Mahmoud, Shaimaa Helmy El-Sayed, Enas Mohamed Ali Rizk, Amira Raafat, Mohamed Sherif Ismail Negm
Schistosomiasis mansoni is considered one of the most common fibrotic diseases resulting from inflammation and deposition of fibrous tissue around parasitic eggs trapped in the liver, causing morbidity and mortality. Chemotherapy against schistosomiasis is largely dependent on Praziquantel (PZQ). Yet, the huge administration of it in endemic areas and its incompetence towards the immature stages have raised serious alarms against the development of drug resistance. Few drugs are directed to reverse schistosomal liver fibrosis, particularly at the chronic and advanced stages of the disease...
January 10, 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29330531/low-density-neutrophils-ldn-in-postoperative-abdominal-cavity-assist-the-peritoneal-recurrence-through-the-production-of-neutrophil-extracellular-traps-nets
#6
Rihito Kanamaru, Hideyuki Ohzawa, Hideyo Miyato, Shiro Matsumoto, Hidenori Haruta, Kentaro Kurashina, Shin Saito, Yoshinori Hosoya, Hironori Yamaguchi, Hiroharu Yamashita, Yasuyuki Seto, Alan Kawarai Lefor, Naohiro Sata, Joji Kitayama
Many types of immune cells appear in peritoneal cavity after abdominal surgery. In patients who underwent laparotomy due to gastric cancer, peritoneal lavages were obtained before and after surgical procedure. Cells were recovered from intermediate layer after Ficoll-Hypaque centrifugation and analyzed for phenotypes and functions, especially focused on low density neutrophils (LDN). The number of CD66b (+) LDN with mature phenotype was markedly elevated in postoperative as compared with preoperative lavages...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29329939/enhanced-mobility-of-non-aqueous-phase-liquid-napl-during-drying-of-wet-sand
#7
Dhivakar Govindarajan, Abhijit P Deshpande, Ravikrishna Raghunathan
Enhanced upward mobility of a non aqueous phase liquid (NAPL) present in wet sand during natural drying, and in the absence of any external pressure gradients, is reported for the first time. This mobility was significantly higher than that expected from capillary rise. Experiments were performed in a glass column with a small layer of NAPL-saturated sand trapped between two layers of water-saturated sand. Drying of the wet sand was induced by flow of air across the top surface of the wet sand. The upward movement of the NAPL, in the direction of water transport, commenced when the drying effect reached the location of the NAPL and continued as long as there was significant water evaporation in the vicinity of NAPL, indicating a clear correlation between the NAPL rise and water evaporation...
January 4, 2018: Journal of Contaminant Hydrology
https://www.readbyqxmd.com/read/29328646/vibrational-properties-of-bulk-boric-acid-2a-and-3t-polymorphs-and-their-two-dimensional-layers-measurements-and-density-functional-theory-calculations
#8
Mauricelio Bezerra da Silva, Regina C R Santos, Paulo T C Freire, Ewerton W S Caetano, Valder N Freire
Boric acid (H3BO3) is being used effectively nowadays in traps/baits for the management of Aedes aegypti L. and Aedes albopictus Skuse species of mosquitoes, which are the main spreading vectors worldwide for diseases like malaria, dengue and zika. Previously, we have published results on the structural, electronic and optical properties of its molecular triclinic H3BO3-2A and trigonal H3BO3-3T polymorphs within the framework of density functional theory (DFT). Due to the renewed importance of these materials, the focus of this work is on the vibrational properties of the bulk boric acid 2A and 3T polymorphs...
January 12, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29327231/loading-of-the-condylar-cartilage-can-rescue-the-effects-of-botox-on-tmj
#9
Eliane H Dutra, Mara H O'Brien, Candice Logan, Aditya Tadinada, Ravindra Nanda, Sumit Yadav
The purpose of this study is to evaluate whether the effects of botulinum neurotoxin (botox) injection into the masseter in the mandibular condylar cartilage (MCC) and subchondral bone could be rescued by compressive loading of the temporomandibular joint (TMJ). Twenty-four 6-week-old female mice (C57BL/6J) were used. Mice were divided in three groups: (1) Botox (n = 8); (2) Botox plus loading (n = 8); (3) Pure control (n = 8). Bone labels (3 and 1 day before sacrifice) and the proliferation marker EdU (2 and 1 day before sacrifice) were intraperitoneally injected into all groups of mice...
January 11, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29325573/genetic-diversity-of-three-surface-protein-genes-in-plasmodium-malariae-from-three-asian-countries
#10
Suttipat Srisutham, Naowarat Saralamba, Kanlaya Sriprawat, Mayfong Mayxay, Frank Smithuis, Francois Nosten, Sasithon Pukrittayakamee, Nicholas P J Day, Arjen M Dondorp, Mallika Imwong
BACKGROUND: Genetic diversity of the three important antigenic proteins, namely thrombospondin-related anonymous protein (TRAP), apical membrane antigen 1 (AMA1), and 6-cysteine protein (P48/45), all of which are found in various developmental stages of Plasmodium parasites is crucial for targeted vaccine development. While studies related to the genetic diversity of these proteins are available for Plasmodium falciparum and Plasmodium vivax, barely enough information exists regarding Plasmodium malariae...
January 11, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29325226/citrullinated-histone-h3-a-biomarker-of-neutrophil-extracellular-trap-formation-predicts-the-risk-of-venous-thromboembolism-in-cancer-patients
#11
Lisa-Marie Mauracher, Florian Posch, Kimberly Martinod, Ella Grilz, Thomas Däullary, Lena Hell, Christine Brostjan, Christoph Zielinski, Cihan Ay, Denisa D Wagner, Ingrid Pabinger, Johannes Thaler
BACKGROUND: Neutrophil extracellular traps (NETs) are decondensed chromatin fibers which might play a role in the prothrombotic state of cancer patients. OBJECTIVES: Here we investigated whether citrullinated histone H3 (H3Cit), a biomarker for NET formation, cell-free DNA (cfDNA), and nucleosomes predict venous thromboembolism (VTE) in cancer patients. PATIENTS/METHODS: Nine-hundred-forty-six patients with newly-diagnosed cancer or progression after remission were enrolled in this prospective observational cohort study...
January 11, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29324085/hyperparasitism-of-an-avian-ectoparasitic-hippoboscid-fly-ornithomya-anchineuria-by-the-mite-myialges-cf-borealis-in-alberta-canada
#12
Cameron P Goater, Jayden Dyck, Heather Proctor, Kevin Floate
Hippoboscid flies (Diptera: Hippoboscidae) include species that are ectoparasites of birds in the Northern Hemisphere, but little is known regarding their taxonomy, parasites, avian host associations, or geographical distribution in North America. In late August of 2013 and 2014, we collected hippoboscid flies from live birds trapped in mist nets as part of a banding study in Cypress Hills Interprovincial Park in southeastern Alberta, Canada. A total of 113 birds comprising 9 species was examined in 2013. Of these, 18 individuals were infested with 1-3 Ornithomya anchineuria Speiser (n = 22 flies; prevalence = 15...
January 11, 2018: Journal of Parasitology
https://www.readbyqxmd.com/read/29322965/endovascular-strategies-for-management-of-intradural-vertebral-artery-dissecting-aneurysms
#13
Swati D Chinchure, Vijay Jaykrishnan, B P Krishna Prasad
OBJECTIVE: Endovascular treatment of vertebral intradural dissecting aneurysms is complex and requires different strategies for each case. The current study aims to classify these aneurysms for an easy selection of optimal strategies for endovascular therapy. MATERIALS AND METHODS: This study is a retrospective evaluation of 10 patients harbouring a vertebral intradural dissecting aneurysm (including 6 female and 4 male patients). The clinical, procedural, and angiographic data were evaluated...
January 2018: Neurology India
https://www.readbyqxmd.com/read/29322769/composition-microstructure-and-electrical-performances-of-sputtered-sno-thin-film-for-p-type-oxide-semiconductor
#14
Seung Jun Lee, Yoon Jin Jang, Han Joon Kim, Eun Suk Hwang, Seok Min Jeon, Jun Shik Kim, Taehwan Moon, Kyung-Tae Jang, Young-Chang Joo, Deok-Yong Cho, Cheol Seong Hwang
P-Type SnO thin films were deposited on Si substrate by a co-sputtering process using ce-ramic SnO and metal Sn targets at room temperature without adding oxygen. By varying the DC sputtering power applied to the Sn target while maintaining the RF power to the SnO target constant, the Sn:O ratio could vary from 56:44 to 74:26 at the as-deposited state. After the thermal annealing at 180 oC for 25 min under air atmosphere using a microwave annealing system, the films were crystallized into the tetragonal SnO while the Sn:O ratio became from 44:56 to 57:43...
January 11, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29322056/field-evaluation-of-outdoor-ultra-low-volume-ulv-applications-against-phlebotomine-sand-flies-diptera-psychodidae-in-al-rabta-north-west-of-libya
#15
Mostafa Ramahdan Dokhan, Mohamed Amin Kenawy, Taher Shaibi, Badereddin Bashir Annajar
Background: Al Rabta is a rural area in the North-West of Libya that represents an important focus of zoonotic cutaneous leishmaniasis. This study aimed to evaluate the effect of Ultra Low Volume (ULV) applications in controlling sand flies and its impact on leishmaniasis transmission in this area. Methods: Two neighboring villages were selected: Al Rabta West (RW) as cypermethrin treated village and Al Rabta East (RE) as check one. The ULV was evaluated through 3 spraying cycles during Apr, Jun and Sep 2013...
September 2017: Journal of Arthropod-borne Diseases
https://www.readbyqxmd.com/read/29320941/progressive-delayed-respiratory-complications-of-sulfur-mustard-poisoning-in-43-iranian-veterans-three-decades-after-exposure
#16
E Darchini-Maragheh, M Balali-Mood, M Malaknezhad, S R Mousavi
The most common delayed complication of sulfur mustard (SM) poisoning has been observed in the respiratory tracts. It was thus aimed to investigate the delayed respiratory complications in SM-exposed patients around 25 years before the study. Forty-three veterans with more than 25% disability of due to SM poisoning were investigated. Clinical examinations as well as pulmonary function test (PFT) were performed. High-resolution computed tomography (HRCT) of the lungs was done as clinically indicated. Triad of chronic cough, dyspnea, and expectoration were the most common symptoms that were recorded in 88...
February 2018: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29320512/killing-wolves-to-prevent-predation-on-livestock-may-protect-one-farm-but-harm-neighbors
#17
Francisco J Santiago-Avila, Ari M Cornman, Adrian Treves
Large carnivores, such as gray wolves, Canis lupus, are difficult to protect in mixed-use landscapes because some people perceive them as dangerous and because they sometimes threaten human property and safety. Governments may respond by killing carnivores in an effort to prevent repeated conflicts or threats, although the functional effectiveness of lethal methods has long been questioned. We evaluated two methods of government intervention following independent events of verified wolf predation on domestic animals (depredation) in the Upper Peninsula of Michigan, USA between 1998-2014, at three spatial scales...
2018: PloS One
https://www.readbyqxmd.com/read/29319311/chiral-silver-lanthanide-metal-organic-frameworks-comprised-of-one-dimensional-triple-right-handed-helical-chains-based-on-ln7-%C3%AE-3-oh-8-13-clusters
#18
Yan Guo, Lijuan Zhang, Nadeem Muhammad, Yan Xu, Yunshan Zhou, Fang Tang, Shaowei Yang
Three new isostructural chiral silver-lanthanide heterometal-organic frameworks [Ag3Ln7(μ3-OH)8(bpdc)6(NO3)3(H2O)6](NO3)·2H2O [Ln = Eu (1), Tb (2, Sm (3); H2bpdc = 2,2'-bipyridine-3,3'-dicarboxylic acid] based on heptanuclear lanthanide clusters [Ln7(μ3-OH)8]13+ comprised of one-dimensional triple right-handed helical chains were hydrothermally synthesized. Various means such as UV-vis spectroscopy, IR spectroscopy, elemental analysis, powder X-ray diffraction, and thermogravimetric/differential thermal analysis were used to characterize the compounds, wherein compound 3 was crystallographically characterized...
January 10, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29319211/design-and-assembly-of-covalently-functionalized-polyoxofluorovanadate-molecular-hybrids
#19
Maria Nicolaou, Michael Papanikolaou, Athanassios Tsipis, Themistoklis Kabanos, Anastasios Keramidas, Stephen Sproules, Haralampos N Miras
Mixed-valent polyoxometalate (POM) clusters are one of the most interesting host species showing a wide range of structural features and properties. We report the facile preparation and functionalization of a mixed-valent polyoxofluorovanadates where two electrons are trapped to antipodal sites of the clusters. The first members of this family of clusters with the general formula, [VV12VIV2O16(μ-O)10(μ3-O)10(μ3-F)2(L)2]6-, where L: py = pyridine (1); pyr = pyrazine (2); im = imidazole (3), are unique organic-inorganic hybrids with the addition of a N-donor ligand at either end of the polyoxofluorovanadate...
January 10, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29318411/cyclophilin-a-increases-cd68-cell-infiltration-in-rat-experimental-periodontitis
#20
Lande Xue, Linwang Su, Li Zhao, Jianxia Li, Yi Du, Xijiao Yu
Cyclophilin A (CyPA) is a potent chemokine, which can directly induce leukocyte chemotaxis and contribute to the pathogenesis of inflammation-mediated diseases. This study is to observe the expression and distribution of CyPA and CD68+ cells in the histopathogenesis of rat ligation-induced experimental periodontitis, and assess the role of CyPA in CD68+ cell infiltration in rat experimental periodontitis. Experimental periodontitis was induced by ligation according to our previous method. CyPA expression in gingival tissues was detected by western blotting...
January 9, 2018: Journal of Molecular Histology
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