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https://www.readbyqxmd.com/read/28213534/quantitative-correlation-between-infectivity-and-gp120-density-on-hiv-1-virions-revealed-by-optical-trapping-virometry
#1
Michael C DeSantis, Jin H Kim, Hanna Song, Per Johan Klasse, Wei Cheng
No abstract text is available yet for this article.
February 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28213126/the-galactose-induced-decrease-in-phosphate-levels-leads-to-toxicity-in-yeast-models-of-galactosemia
#2
Caio M Machado, Evandro A De-Souza, Ana Luiza F V De-Queiroz, Felipe S A Pimentel, Guilherme F S Silva, Fabio M Gomes, Mónica Montero-Lomelí, Claudio A Masuda
Classic galactosemia is an inborn error of metabolism caused by deleterious mutations in the GALT gene. A number of evidences indicate that the galactose-1-phosphate accumulation observed in patient cells is a cause of toxicity in this disease. Nevertheless, the consequent molecular events caused by the galactose-1-phosphate accumulation remain elusive. Here we show that intracellular inorganic phosphate levels decreased when yeast models of classic galactosemia were exposed to galactose. The decrease in phosphate levels is probably due to the trapping of phosphate in the accumulated galactose-1-phosphate since the deletion of the galactokinase encoding gene GAL1 suppressed this phenotype...
February 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28212379/distribution-and-abundance-of-key-vectors-of-rift-valley-fever-and-other-arboviruses-in-two-ecologically-distinct-counties-in-kenya
#3
Rosemary Sang, Samwel Arum, Edith Chepkorir, Gladys Mosomtai, Caroline Tigoi, Faith Sigei, Olivia Wesula Lwande, Tobias Landmann, Hippolyte Affognon, Clas Ahlm, Magnus Evander
BACKGROUND: Rift Valley fever (RVF) is a mosquito-borne viral zoonosis of ruminants and humans that causes outbreaks in Africa and the Arabian Peninsula with significant public health and economic consequences. Humans become infected through mosquito bites and contact with infected livestock. The virus is maintained between outbreaks through vertically infected eggs of the primary vectors of Aedes species which emerge following rains with extensive flooding. Infected female mosquitoes initiate transmission among nearby animals, which amplifies virus, thereby infecting more mosquitoes and moving the virus beyond the initial point of emergence...
February 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28211620/benchmark-ditopic-binding-of-cl-and-cs-by-the-macrocycle-hexacyclen
#4
Juan Ramon Aviles-Moreno, Giel Berden, Jos Oomens, Bruno Martinez-Haya
The ditopic binding of organic and inorganic anions and cations constitutes a distinct feature of polyazamacrocycles that underlies their action as intermediate docking and exchange ionophoric sites for tailored supramolecular synthesis and sensors. This work investigates the Cl- and Cs+ complexes formed by hexacyclen (1,4,7,10,13,16-hexaazacyclooctadecane, ha18c6), a benchmark building block of ion-pair polyamine receptors. Infrared action spectroscopy is employed to characterize the anionic and cationic complexes under controlled environmental conditions in an ion trap...
February 17, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28210946/an-online-spe-lc-ms-ms-method-for-the-analysis-of-antibiotics-in-environmental-water
#5
Meierjohann Axel, Kortesmäki Ewelina, Brozinski Jenny-Maria, Kronberg Leif
A fast and simple method for the analysis of 17 commonly used antibiotics in Finland in water samples was developed. The method combines online solid phase extraction using a reusable online trapping column combined with analytical separation on a C18 analytical column and detection by a triple quadrupole mass spectrometer. The method was fully validated for detection and quantification limits as well as linearity, repeatability, and matrix effects. The method gave an excellent linear response (r (2) > 0...
February 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28209487/lipoxin-a4-suppresses-osteoclastogenesis-in-raw264-7-cells-and-prevents-ovariectomy-induced-bone-loss
#6
Changyu Liu, Hanfeng Guan, Cong Cai, Feng Li, Jun Xiao
Lipoxin A4 (LXA4; 5S, 6R, 15Strihydroxy- 7,9,13-trans-11-eicosatetraenoic acid) is a metabolic product of arachidonic acid under the action of lipoxidase. This lipid molecule plays important roles in several biological functions, especially inflammatory processes. In vivo, LXA4 regulates the inflammatory response through several signaling pathways. Its mechanism suggests that it might have an effect on osteoclastogenesis and bone loss. Using both in vitro and in vivo studies, it was here observed that LXA4 could significantly inhibit the formation and function of osteoclasts and these effects could be blocked by Boc-2, the specific inhibitor of FPR2/ALX (the receptor of LXA4)...
February 13, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28209030/effects-of-annealing-ambient-on-the-characteristics-of-laalo3-films-grown-by-atomic-layer-deposition
#7
Lu Zhao, Hong-Xia Liu, Xing Wang, Chen-Xi Fei, Xing-Yao Feng, Yong-Te Wang
We investigated the effects of different annealing ambients on the physical and electrical properties of LaAlO3 films grown by atomic layer deposition. Post-grown rapid thermal annealing (RTA) was carried out at 600 °C for 1 min in vacuum, N2, and O2, respectively. It was found that the chemical bonding states at the interfacial layers (ILs) between LaAlO3 films and Si substrate were affected by the different annealing ambients. The formation of IL was enhanced during the RTA process, resulting in the decrease of accumulation capacitance, especially in O2 ambient...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28208343/collective-colloid-diffusion-under-soft-two-dimensional-confinement
#8
S Panzuela, Raúl P Peláez, R Delgado-Buscalioni
This work presents a numerical and theoretical investigation of the collective dynamics of colloids in an unbounded solution but trapped in a harmonic potential. Under strict two-dimensional confinement (infinitely stiff trap) the collective colloidal diffusion is enhanced and diverges at zero wave number (like k^{-1}), due to the hydrodynamic propagation of the confining force across the layer. The analytic solution for the collective diffusion of colloids under a Gaussian trap of width δ still shows enhanced diffusion for large wavelengths kδ<1, while a gradual transition to normal diffusion for kδ>1...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28207598/newly-formed-bone-induced-by-recombinant-human-bone-morphogenetic-protein-2-a-histological-observation
#9
Azumi Hirata, Takaaki Ueno, Peter K Moy
PURPOSE: To observe, histologically, bone induced by recombinant human bone morphogenetic protein-2 (rhBMP-2) in onlay grafted and sinus lifted alveolaris. MATERIAL AND METHODS: Eighteen patients were treated with rhBMP-2 at concentration 1.5 mg/mL with an absorbable collagen sponge (ACS). The treated bone was harvested with small trephine bur at 5 or 7 months after surgery for the micro Computer Scanning (CT) and light microscopic observation. RESULTS: Micro CT showed clearly 3-dimensional trabecular bone structure...
February 14, 2017: Implant Dentistry
https://www.readbyqxmd.com/read/28205630/synthesis-of-pt-k2co3-mgalox-reduced-graphene-oxide-hybrids-as-promising-nox-storage-reduction-catalysts-with-superior-catalytic-performance
#10
Xueyi Mei, Qinghua Yan, Peng Lu, Junya Wang, Yuhan Cui, Yu Nie, Ahmad Umar, Qiang Wang
Pt/K2CO3/MgAlOx-reduced graphene oxide (Pt/K/MgAlOx-rGO) hybrids were synthesized, characterized and tested as a promising NOx storage and reduction (NSR) catalyst. Mg-Al layered double hydroxides (LDHs) were grown on rGO via in situ hydrothermal crystallization. The structure and morphology of samples were thoroughly characterized using various techniques. Isothermal NOx adsorption tests indicated that MgAlOx-rGO hybrid exhibited better NOx trapping performance than MgAlOx, from 0.44 to 0.61 mmol · g(-1), which can be attributed to the enhanced particle dispersion and stabilization...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28205515/tailored-protein-encapsulation-into-a-dna-host-using-geometrically-organized-supramolecular-interactions
#11
Andreas Sprengel, Pascal Lill, Pierre Stegemann, Kenny Bravo-Rodriguez, Elisa-C Schöneweiß, Melisa Merdanovic, Daniel Gudnason, Mikayel Aznauryan, Lisa Gamrad, Stephan Barcikowski, Elsa Sanchez-Garcia, Victoria Birkedal, Christos Gatsogiannis, Michael Ehrmann, Barbara Saccà
The self-organizational properties of DNA have been used to realize synthetic hosts for protein encapsulation. However, current strategies of DNA-protein conjugation still limit true emulation of natural host-guest systems, whose formation relies on non-covalent bonds between geometrically matching interfaces. Here we report one of the largest DNA-protein complexes of semisynthetic origin held in place exclusively by spatially defined supramolecular interactions. Our approach is based on the decoration of the inner surface of a DNA origami hollow structure with multiple ligands converging to their corresponding binding sites on the protein surface with programmable symmetry and range-of-action...
February 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/28204822/melittin-inhibits-osteoclast-formation-through-the-downregulation-of-the-rankl-rank-signaling-pathway-and-the-inhibition-of-interleukin-1%C3%AE-in-murine-macrophages
#12
Jung-Yoon Choe, Seong-Kyu Kim
Melittin is a major toxic component of bee venom (Apis mellifera). It is not known whether melittin is involved in bone metabolism and osteoclastogenesis. The aim of this study was to determine the role of melittin in the regulation of osteoclastogenesis. In vitro osteoclastogenesis assays were performed using mouse RAW 264.7 cells and bone marrow-derived macrophages (BMMs) treated with receptor activator of nuclear factor-κB ligand (RANKL) and macrophage colony-stimulating factor (M-CSF). Morphologic and functional analyses for osteoclast-like multinucleated cells (MNCs) were performed by tartrate-resistant acid phosphatase (TRAP) staining, F-actin staining and pit formation methods...
February 3, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28204821/neutrophil-extracellular-traps-induce-il-1%C3%AE-production-by-macrophages-in-combination-with-lipopolysaccharide
#13
Zhongshuang Hu, Taisuke Murakami, Hiroshi Tamura, Johannes Reich, Kyoko Kuwahara-Arai, Toshiaki Iba, Yoko Tabe, Isao Nagaoka
Upon exposure to invading microorganisms, neutrophils undergo NETosis, a recently identified type of programmed cell death, and release neutrophil extracellular traps (NETs). NETs are described as an antimicrobial mechanism, based on the fact that NETs can trap microorganisms and exhibit bactericidal activity through the action of NET‑associated components. In contrast, the components of NETs have been recognized as damage‑associated molecular pattern molecules (DAMPs), which trigger inflammatory signals to induce cell death, inflammation and organ failure...
January 27, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28203012/-effects-of-saliva-contamination-on-bond-strength-of-resin-resin-interfaces
#14
H J Guo, C Z Gao, F Lin, W Liu, L Yue
OBJECTIVE: To estimate the bond strength between different resin composite interfaces, and to evaluate the effect of saliva contamination and management with the contamination on the bond strength. METHODS: Two commercial resin composites containing different types of fillers (AP-X: barium-glass; P60: quartz) were tested in this study. The basic composite blocks were made of AP-X. After wet-ground flatted, the experimental groups were divided into three groups according to the surface treatment: (1)Direct bonding group: the bonding surface was rinsed with distilled water for 20 s, then dried with oil-free air for 20 s; (2)Saliva contamination group: the bonding surface was bathed in saliva for 30 min, then distilled water was rinsed for 20 s and dried with oil-free air for 20 s; (3)Saliva contamination and 75% ethanol wiping group: bonding surface bathed in saliva for 30 min, then wipe the surface with 75% ethanol, distilled water rinse for 20 s and dry with oil-free air for 20 s; The control group was made of the basic composite bulks of AP-X directly bonding with composite P60...
February 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28203000/-effect-of-molar-ligation-and-local-porphyromonas-gingivalis-inoculation-on-alveolar-bone-loss-in-the-mouse
#15
L Gao, X Q Yu, Y Cai
OBJECTIVE: To compare the extent and time course of alveolar bone loss and osteoclast activation in two murine models of periodontal disease: molar ligation and Porphyromonas gingivalis (P. gingivalis) oral inoculation. METHODS: A split-mouth design was applied to two groups of mice (C57BL6, 6-8 weeks old, n=24 in both groups), resulting in four treatment groups: (1) Control group: unligated upper right 2nd molars receiving CMC only, (2)Ligature group: ligation of a 9-0 suture around the upper left 2nd molar, (3) P...
February 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28202055/harmonizing-methods-for-wildlife-abundance-estimation-and-pathogen-detection-in-europe-a-questionnaire-survey-on-three-selected-host-pathogen-combinations
#16
Jana Sonnenburg, Marie-Pierre Ryser-Degiorgis, Thijs Kuiken, Ezio Ferroglio, Rainer G Ulrich, Franz J Conraths, Christian Gortázar, Christoph Staubach
BACKGROUND: The need for wildlife health surveillance as part of disease control in wildlife, domestic animals and humans on the global level is widely recognized. However, the objectives, methods and intensity of existing wildlife health surveillance programs vary greatly among European countries, resulting in a patchwork of data that are difficult to merge and compare. This survey aimed at evaluating the need and potential for data harmonization in wildlife health in Europe. The specific objective was to collect information on methods currently used to estimate host abundance and pathogen prevalence...
February 16, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28199946/bioavailability-and-bioaccessibility-of-polycyclic-aromatic-hydrocarbons-from-post-pyrolytically-treated-biochars
#17
Isabel Hilber, Philipp Mayer, Varvara Gouliarmou, Sarah E Hale, Gerard Cornelissen, Hans-Peter Schmidt, Thomas D Bucheli
Bioaccessibility data of PAHs from biochar produced under real world conditions is scarce and the influence of feedstock and various post-pyrolysis treatments common in agriculture, such as co-composting or lacto-fermentation to produce silage fodder, on their bioavailability and bioaccessibility has hardly been studied. The total (Ctotal), and freely dissolved (i.e., bioavailable) concentrations (Cfree) of the sum of 16 US EPA PAHs of 43 biochar samples produced and treated in such ways ranged from 0.4 to almost 2000 mg/kg, and from 12 to 81 ng/L, respectively, which resulted in very high biochar-water partition coefficients (4...
February 4, 2017: Chemosphere
https://www.readbyqxmd.com/read/28197928/enhanced-reactivity-in-nucleophilic-acyl-substitution-ion-ion-reactions-using-triazole-ester-reagents
#18
Jiexun Bu, Zhou Peng, Feifei Zhao, Scott A McLuckey
The acyl substitution reactions between 1-hydroxy-7-aza-benzotriazole (HOAt)/1-hydroxy-benzotriazole (HOBt) ester reagents and nucleophilic side chains on peptides have been demonstrated in the gas phase via ion/ion reactions. The HOAt/HOBt ester reagents were synthesized in solution and ionized via negative nano-electrospray ionization. The anionic reagents were then reacted with doubly protonated model peptides containing amines, guanidines, and imidazoles in the gas phase. The complexes formed in the reaction cell were further probed with ion trap collision induced dissociation (CID) yielding either a covalently modified analyte ion or a proton transfer product ion...
February 14, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28194825/differential-gelation-and-self-sorting-properties-of-two-isomeric-polyamides-due-to-the-parallel-vs-anti-parallel-alignment-of-backbone-dipoles
#19
Chui-Fan Leung, Hak-Fun Chow
Two isomeric bottlebrush polyamides P-1 and A-1 having the same repeating monomer dipole units aligned along the polymer backbone in pseudo-parallel and pseudo-anti-parallel, respectively, were synthesized and characterized. Both polymers can form thermoreversible gels with aromatic solvents but P-1 was found to show inferior gelation strength as compared to that of A-1. Furthermore, despite their close structural resemblance, a 1:1 mixture of the P-1 and A-1 polymers was shown to exhibit self-sorting in the gel state...
February 14, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28193291/meteorological-variables-and-mosquito-monitoring-are-good-predictors-for-infestation-trends-of-aedes-aegypti-the-vector-of-dengue-chikungunya-and-zika
#20
Danielle Andreza da Cruz Ferreira, Carolin Marlen Degener, Cecilia de Almeida Marques-Toledo, Maria Mercedes Bendati, Liane Oliveira Fetzer, Camila P Teixeira, Álvaro Eduardo Eiras
BACKGROUND: Aedes aegypti is an important vector for arboviroses and widely distributed throughout the world. Climatic factors can influence vector population dynamics and, consequently, disease transmission. The aim of this study was to characterize the temporal dynamics of an Ae. aegypti population and dengue cases and to investigate the relationship between meteorological variables and mosquito infestation. METHODS: We monitored and analyzed the adult female Ae...
February 13, 2017: Parasites & Vectors
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