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https://www.readbyqxmd.com/read/28316994/multiple-factors-involved-in-the-pathogenesis-of-white-matter-lesions
#1
REVIEW
Jing Lin, Dilong Wang, Linfang Lan, Yuhua Fan
White matter lesions (WMLs), also known as leukoaraiosis (LA) or white matter hyperintensities (WMHs), are characterized mainly by hyperintensities on T2-weighted or fluid-attenuated inversion recovery (FLAIR) images. With the aging of the population and the development of imaging technology, the morbidity and diagnostic rates of WMLs are increasing annually. WMLs are not a benign process. They clinically manifest as cognitive decline and the subsequent development of dementia. Although WMLs are important, their pathogenesis is still unclear...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28303346/high-throughput-sequencing-identifies-hiv-1-replication-and-latency-related-mirnas-in-cd4-t-cell-lines
#2
Xiangyun Lu, Jin Yang, Haibo Wu, Zongxing Yang, Changzhong Jin, Juan Wang, Linfang Cheng, Xiaorong Peng, Fumin Liu, Xiuming Peng, Sujing Ji, Huilin Ou, Tiansheng Xie, Hangping Yao, Nanping Wu
MicroRNAs are potent gene expression regulators involved in regulating various biological processes, including host-pathogen interactions. In this study, we used high-throughput sequencing to investigate cellular miRNA signatures related to HIV-1 replication and latent infection in CD4(+) T cell lines, which included HIV-1-replicating H9/HTLV-IIIB, HIV-1-latently-infected CEM-Bru cells, and their parental uninfected H9 and CEM-SS cells. Relatively few miRNAs were found to be modulated by HIV-1 replication or latent infection, while the cell-lineage-specific miRNA difference was more pronounced, irrespective of HIV-1 infection...
March 16, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28277741/characterization-and-complementation-of-a-chlorophyll-less-dominant-mutant-gl1-in-lagerstroemia-indica
#3
Shu'an Wang, Peng Wang, Lulu Gao, Rutong Yang, Linfang Li, Enliang Zhang, Qing Wang, Ya Li, Zengfang Yin
Crape myrtle (Lagerstroemia indica) is a woody ornamental plant popularly grown because of its long-lasting, midsummer blooms and beautiful colors. The GL1 dominant mutant is the first chlorophyll-less mutant identified in crape myrtle. It was obtained from a natural yellow leaf bud mutation. We previously revealed that leaf color of the GL1 mutant is affected by light intensity. However, the mechanism of the GL1 mutant on light response remained unclear. The acclimation response of mutant and wild-type (WT) plants was assessed in a time series after transferring from low light (LL) to high light (HL) by analyzing chlorophyll synthesis precursor content, photosynthetic performance, and gene expression...
March 9, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28244490/the-rna-binding-protein-qki5-regulates-primary-mir-124-1-processing-via-a-distal-rna-motif-during-erythropoiesis
#4
Fang Wang, Wei Song, Hongmei Zhao, Yanni Ma, Yuxia Li, Di Zhai, Jingnan Pi, Yanmin Si, Jiayue Xu, Lei Dong, Rui Su, Mengmeng Zhang, Yong Zhu, Xiaoxia Ren, Fei Miao, Wenjie Liu, Feng Li, Junwu Zhang, Aibin He, Ge Shan, Jingyi Hui, Linfang Wang, Jia Yu
MicroRNA (miRNA) biogenesis is finely controlled by complex layers of post-transcriptional regulators, including RNA-binding proteins (RBPs). Here, we show that an RBP, QKI5, activates the processing of primary miR-124-1 (pri-124-1) during erythropoiesis. QKI5 recognizes a distal QKI response element and recruits Microprocessor through interaction with DGCR8. Furthermore, the recruited Microprocessor is brought to pri-124-1 stem loops by a spatial RNA-RNA interaction between two complementary sequences. Thus, mutations disrupting their base-pairing affect the strength of QKI5 activation...
March 2017: Cell Research
https://www.readbyqxmd.com/read/28123600/activation-or-suppression-of-the-immune-response-mediators-in-biliary-tract-cancer-btc-patients-a-systematic-review-and-meta-analysis
#5
Ying Wang, Min Ding, Qian Zhang, Jinghan Wang, Xijing Yang, Fuping Zhou, Linfang Li, Zhengang Yuan, Huajun Jin, Qijun Qian
Background: Infiltration of immune cells and immune microenvironment determine the proliferative activity of the tumor and metastasis. The aim of this study was to analyze the influence of activation or suppression of the immune response mediators on the prognosis of biliary tract cancer (BTC). Methods: We searched Pubmed, Web of Science, Embase and The Cochrane Library for relevant literatures until June 2016. The quality of studies was assessed by QUADAS-2 and NOS tools. Forest and funnel plots and all statistical analyses were generated by using Review Manager 5...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28106104/high-aldh1-expression-correlates-with-better-prognosis-in-tumorigenic-malignant-melanoma
#6
Laura A Taylor, Ronnie M Abraham, Emin Tahirovic, Patricia van Belle, Bin Li, Linfang Huang, David E Elder, Phyllis Gimotty, Xiaowei Xu
Aldehyde dehydrogenase 1 (ALDH1) has been proposed as biomarker of stem cells for certain human cancers. ALDH1 expression has been correlated with poor patient outcomes in a variety of malignancies but better patient outcomes in others, and its prognostic significance in malignant melanoma is unclear. Thus, 68 melanoma patients with comprehensive clinical and pathologic follow-up data were used to construct a tissue microarray. A modified histological score (H-score) with a maximum score of 300 was used to quantify immunohistochemical staining for ALDH1...
January 20, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28105530/molecular-characterization-of-a-novel-reassortant-h7n6-subtype-avian-influenza-virus-from-poultry-in-eastern-china-in-2016
#7
Haibo Wu, Rufeng Lu, Xiuming Peng, Xiaorong Peng, Bin Chen, Linfang Cheng, Nanping Wu
During the surveillance for avian influenza viruses (AIVs) in live poultry markets in Eastern China, in 2016, a novel reassortant H7N6 AIV was isolated from a chicken. Phylogenetic analysis showed that this strain received its genes from H9N2, H7N9 and H5N6 AIVs infecting poultry in China. This strain showed moderate pathogenicity in mice and was able to replicate in mice without prior adaptation. Considering that this novel reassorted H7N6 virus was isolated from poultry in this study, it is possible that chickens play an important role in the generation of novel reassorted H7N6 AIVs...
January 19, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28067615/intracranial-atherosclerosis-from-anatomy-to-pathophysiology
#8
Yuehua Pu, Linfang Lan, Xinyi Leng, Lawrence Ks Wong, Liping Liu
Background Intracranial atherosclerotic stenosis is an important etiology subtype of ischemic stroke. Stenosis severity was thought to be the main reference index for clinical treatment and research. However, stenosis could not reflect the ischemia risk completely, instead the hemodynamic state across the lesion, the extent of collateral circulation, and perfusion impairment downstream the stenosis are more important. Aims We write this review aimed to summarize novel angiographic methods applied in the evaluation of functional severity of ICAS, and commented on their limitations and prospects in future research...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28032400/increasing-circulating-exosomes-carrying-trpc5-predicts-chemoresistance-in-metastatic-breast-cancer-patients
#9
Teng Wang, Kuan Ning, Ting-Xun Lu, Xu Sun, Linfang Jin, Xiaowei Qi, Jian Jin, Dong Hua
Chemoresistance, the major obstacle in breast cancer chemotherapy, results in unnecessary chemotherapy and wasting of medical resources. Up to now, no feasible method is available to predict chemoresistance before chemotherapy. In our previously study, elevated expression of transient receptor potential channel TRPC5 was found as an essential element for chemoresistance in breast cancer cells, and could be transferred to chemosensitive breast cancer cells through releasing extracellular vesicles (EVs)-containing TRPC5 from chemoresistant cells, resulting in acquired chemoresistance...
December 29, 2016: Cancer Science
https://www.readbyqxmd.com/read/27895148/trpc5-regulates-differentiation-through-the-ca2-wnt5a-signal-pathway-in-colorectal-cancer
#10
Zhen Chen, Chunlei Tang, Yaodan Zhu, Mingxu Xie, Dongxu He, Qiongxi Pan, Peng Zhang, Dong Hua, Teng Wang, Linfang Jin, Xiaowei Qi, Yifei Zhu, Xiaoqiang Yao, Jian Jin, Xin Ma
Transient receptor potential channel 5 (TrpC5) is member of the TrpC subgroup, and it forms a receptor-activated non-selective Ca(2+) channel. The architecture of the TrpC5 channel is poorly understood. Here, we report that TrpC5 is a key factor in regulating differentiation in colorectal cancer. Through a study of specimens from a large cohort of patients with colorectal cancer, we found that TrpC5 was highly expressed and its cellular level correlated with tumor grade. We further showed that up-regulated TrpC5 caused a robust [Ca(2+)]i rise, increased Wnt5a expression, and the nuclear translocation of β-catenin, leading to a reduction of cancer differentiation and an increase of cancer cell stemness...
November 28, 2016: Clinical Science (1979-)
https://www.readbyqxmd.com/read/27768591/preclinical-evaluation-of-the-safety-and-pathogenicity-of-a-live-attenuated-recombinant-influenza-a-h7n9-seed-strain-and-corresponding-mf59-adjuvanted-split-vaccine
#11
Huilin Ou, Wei Yao, Nanping Wu, Frederick X C Wang, Tianhao Weng, Chengcong Han, Xiangyun Lu, Dongshan Yu, Haibo Wu, Linfang Cheng, Honglin Chen, Hangping Yao, Lanjuan Li
Developing a safe and effective H7N9 influenza vaccine was initiated in early spring 2013, following human infections with a novel avian influenza A (H7N9) virus. In this study, a candidate H7N9 vaccine seed strain is produced using reverse genetics, with HA and NA derived from a human H7N9 virus and the remaining genes from the PR8 backbone virus which grows well in eggs. We verified that the virulence and transmissibility of the recombinant H7N9 vaccine seed strain were decreased as compared to wild-type H7N9 virus, to levels comparable with PR8...
October 19, 2016: Oncotarget
https://www.readbyqxmd.com/read/27765898/cerebral-perfusion-difference-between-hemispheres-with-symptomatic-and-asymptomatic-intracranial-arterial-stenosis
#12
Linfang Lan, Xinyi Leng, Jill Abrigo, Vincent Ip, Yannie Oy Soo, Thomas Leung, Xiangyan Chen, Ka Sing Wong
No abstract text is available yet for this article.
October 20, 2016: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/27703431/cistanches-herba-a-neuropharmacology-review
#13
Caimei Gu, Xianying Yang, Linfang Huang
Cistanches Herba (family Orobanchaceae), commonly known as "desert ginseng" or Rou Cong Rong, is a global genus and commonly used for its neuroprotective, immunomodulatory, anti-oxidative, kidney impotence, laxative, anti-inflammatory, hepatoprotective, anti-bacterial, anti-viral, and anti-tumor effects in traditional herbal formulations in North Africa, Arabic, and Asian countries. The major bioactive compound present in this plant is phenylethanoid glycosides. In recent years, there has been great important in scientific investigation of the neuropharmacological effects of the bioactive compounds...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27650950/osteoimmunology-memorandum-for-rheumatologists
#14
REVIEW
Lidan Zhao, Linfang Huang, Xuan Zhang
Rapid progress has been made in exploring the connections between the skeletal system and the immune system over the past decade. Bone tissue forms developmental niches for hematopoietic stem cells, and activated immune cells are involved in bone metabolism regulation and are potent mediators of osteoporosis and bone erosion under pathological conditions. The interdisciplinary field of osteoimmunology has emerged to pool the knowledge of the interdependence of these two systems, including the shared ligands and receptors, their crosstalk and interaction, and common intracellular signaling pathways with bidirectional influence...
December 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27571059/anti-influenza-virus-activity-and-constituents-characterization-of-paeonia-delavayi-extracts
#15
Jinhua Li, Xianying Yang, Linfang Huang
Paeonia delavayi, an endemic species in southwestern China, has been widely used as a traditional remedy for cardiovascular, extravasated blood, stagnated blood and female diseases in traditional Chinese medicine (TCM). However, there are no reports on the anti-influenza virus activity of this species. Here, the anti-influenza virus activity of P. delavayi root extracts was first evaluated by an influenza virus neuraminidase (NA) inhibition assay. Meantime, constituents in the active extracts were identified using ultra-high performance liquid coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) and seven major identified constituents were used to further evaluate the NA inhibitory activity...
August 26, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27535142/lipase-genes-in-mucor-circinelloides-identification-sub-cellular-location-phylogenetic-analysis-and-expression-profiling-during-growth-and-lipid-accumulation
#16
Xinyi Zan, Xin Tang, Linfang Chu, Lina Zhao, Haiqin Chen, Yong Q Chen, Wei Chen, Yuanda Song
Lipases or triacylglycerol hydrolases are widely spread in nature and are particularly common in the microbial world. The filamentous fungus Mucor circinelloides is a potential lipase producer, as it grows well in triacylglycerol-contained culture media. So far only one lipase from M. circinelloides has been characterized, while the majority of lipases remain unknown in this fungus. In the present study, 47 potential lipase genes in M. circinelloides WJ11 and 30 potential lipase genes in M. circinelloides CBS 277...
October 2016: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/27439174/synthesis-of-c-glycosyl-triazolyl-quinoline-based-fluorescent-sensors-for-the-detection-of-mercury-ions
#17
Linfang Wang, Jianzhong Jin, Linwei Zhao, Hongyun Shen, Chao Shen, Pengfei Zhang
A series of novel C-glycosyl triazolyl quinoline-based fluorescent sensors have been synthesized via click chemistry. It was found that novel sensors exhibited good selectivity for Hg(2+) over many other metal ions. The glucose framework was introduced to increase the water-solubility of the fluorescent sensors and broaden its application for the detection of Hg(II) in the water-solubility biological systems. The mechanism of the chemodosimetric behavior of the sensors has been attributed to a binding mode of triazolyl quinoline with Hg(2+) which has been characterized by a number of spectroscopic techniques...
October 4, 2016: Carbohydrate Research
https://www.readbyqxmd.com/read/27409415/severe-dyslipidemia-and-immune-activation-in-hiv-patients-with-dysglycemia
#18
Changzhong Jin, Shujing Ji, Tiansheng Xie, Stefan Höxtermann, Wolfgang Fuchs, Xiangyun Lu, Haibo Wu, Linfang Cheng, Adriane Skaletz-Rorowski, Norbert H Brockmeyer, Nanping Wu
BACKGROUND AND OBJECTIVE: Diabetes mellitus (DM) is common in human immunodeficiency virus (HIV)-infected patients. However, the relationship between dysglycemia, lipid metabolism, and immune activation in HIV patients is poorly understood. METHODS: We retrospectively analyzed the clinical data of 180 HIV patients, including 153 patients undergoing highly active antiretroviral therapy (HAART) and 27 HAART-naive patients. DM was defined as fasting serum glucose levels ≥126 mg/dl, and impaired fasting glucose (IFG) was defined as serum glucose levels of 101-125 mg/dl at two different time points...
September 2016: HIV Clinical Trials
https://www.readbyqxmd.com/read/27379842/genetic-and-molecular-characterization-of-a-novel-reassortant-h2n8-subtype-avian-influenza-virus-isolated-from-a-domestic-duck-in-zhejiang-province-in-china
#19
Haibo Wu, Xiuming Peng, Xiaorong Peng, Linfang Cheng, Nanping Wu
The circulation of the H2 subtype influenza viruses in domestic animals increases the risk of human exposure to these viruses. An H2N8 avian influenza virus (AIV) was isolated from a domestic duck during AIV surveillance of poultry in live poultry markets (LPMs) in Zhejiang Province, Eastern China, in 2013. The phylogenetic trees suggested that this strain is a novel reassortant virus derived from multiple AIV subtypes from aquatic birds and poultry in Eastern Asia. Although this reassortant strain exhibited low pathogenicity in mice, it was able to replicate in the lungs of the mice without prior adaptation...
December 2016: Virus Genes
https://www.readbyqxmd.com/read/27372509/interaction-between-pin1-and-its-natural-product-inhibitor-epigallocatechin-3-gallate-by-spectroscopy-and-molecular-dynamics-simulations
#20
Lei Xi, Yu Wang, Qing He, Qingyan Zhang, Linfang Du
The binding of epigallocatechin-3-gallate (EGCG) to wild type Pin1 in solution was studied by spectroscopic methods and molecular dynamics simulations in this research to explore the binding mode and inhibition mechanism. The binding constants and number of binding sites per Pin1 for EGCG were calculated through the Stern-Volmer equation. The values of binding free energy and thermodynamic parameters were calculated and indicated that hydrogen bonds, electrostatic interaction and Van der Waals interaction played the major role in the binding process...
December 5, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
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