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https://www.readbyqxmd.com/read/29156573/neuraminidase-inhibitory-activity-and-constituent-characterization-of-fagopyrum-dibotrys
#1
Xiang Zhang, Yu Cao, Jinhua Li, Ailin Liu, Haibo Liu, Linfang Huang
This study aimed to identify a new biological activity of the widely distributed species Fagopyrum dibotrys. Four F. dibotrys extracts (ethyl acetate (EA), petroleum ether (P), ethanol (E), and water (W)) were explored for their anti-neuraminidase (NA) activity. A total of 32 compounds were identified using UHPLC-Q-Exactive Orbitrap HRMS in the EA extract, which had the best NA inhibitory effects. We used the docking data for supporting compounds' anti-neuraminidase activity. Among them, five compounds including one flavonoid, three organic acids, and one glucoside were discovered for the first time in F...
November 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29146988/variations-in-nutrient-and-trace-element-composition-of-rice-in-an-organic-rice-frog-coculture-system
#2
Zhimin Sha, Qingnan Chu, Zheng Zhao, Yubo Yue, Linfang Lu, Jing Yuan, Linkui Cao
Introducing frogs into paddy fields can control pests and diseases, and organic farming can improve soil fertility and rice growth. The aim of this 2-year field study was compare the yield and elemental composition of rice between an organic farming system including frogs (ORF) and a conventional rice culture system (CR). The grain yields were almost the same in the ORF system and the CR system. The ORF significantly increased the contents of phosphorus (P), ion (Fe), zinc (Zn), molybdenum (Mo) and selenium (Se) in rice grain at one or both years...
November 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29111361/cerebral-venous-collagen-remodeling-in-a-modified-white-matter-lesions-animal-model
#3
Jing Lin, Linfang Lan, Dilong Wang, Baoshan Qiu, Yuhua Fan
To mimic the expected pathological changes of white matter lesions (WMLs) and increase the stability, we applied modified two-vessel occlusion (modified 2VO) (1-week interval bilateral carotid artery occlusion) in stroke-prone renovascular hypertensive rats (RHRSP) and established a modified WMLs model (RHRSP/modified 2VO) that compared their phenotypes with RHRSP and sham-operated rats. In addition, we tried to differentiate small veins from small arteries through the presence of smooth muscle to study the pathological changes of small veins detailed in the model...
October 31, 2017: Neuroscience
https://www.readbyqxmd.com/read/29107636/impact-of-side-branches-on-the-computation-of-fractional-flow-in-intracranial-arterial-stenosis-using-the-computational-fluid-dynamics-method
#4
Haipeng Liu, Linfang Lan, Xinyi Leng, Hing Lung Ip, Thomas W H Leung, Defeng Wang, Ka Sing Wong
BACKGROUND: Computational fluid dynamics (CFD) allows noninvasive fractional flow (FF) computation in intracranial arterial stenosis. Removal of small artery branches is necessary in CFD simulation. The consequent effects on FF value needs to be judged. METHODS: An idealized vascular model was built with 70% focal luminal stenosis. A branch with one third or one half of the radius of the parent vessel was added at a distance of 5, 10, 15 and 20 mm to the lesion...
October 27, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29050214/prox1-represses-il-2-gene-expression-by-interacting-with-nfat2
#5
Shujie Zhang, Ning Yu, Linfang Wang, Yanfeng Liu, Yuying Kong, Jing Liu, Youhua Xie
Interleukin-2 (IL-2) is critical for T lymphocyte activation and regulated by many transcriptional factors. Prospero-related homeobox 1 (Prox1) is a multifunctional transcription factor, which can work as either a transcriptional activator or repressor depending on the cellular and developmental environment. We previously reported the Prox1 expression in T cells, raising the possibility of Prox1 involvement in the regulation of T cell function and IL-2 production. Here we demonstrated that the Prox1 expression in CD4+ T cells was downregulated by T cell receptor (TCR) activation...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049369/discrimination-and-prediction-of-cultivation-age-and-parts-of-panax-ginseng-by-fourier-transform-infrared-spectroscopy-combined-with-multivariate-statistical-analysis
#6
Byeong-Ju Lee, Hye-Youn Kim, Sa Rang Lim, Linfang Huang, Hyung-Kyoon Choi
Panax ginseng C.A. Meyer is a herb used for medicinal purposes, and its discrimination according to cultivation age has been an important and practical issue. This study employed Fourier-transform infrared (FT-IR) spectroscopy with multivariate statistical analysis to obtain a prediction model for discriminating cultivation ages (5 and 6 years) and three different parts (rhizome, tap root, and lateral root) of P. ginseng. The optimal partial-least-squares regression (PLSR) models for discriminating ginseng samples were determined by selecting normalization methods, number of partial-least-squares (PLS) components, and variable influence on projection (VIP) cutoff values...
2017: PloS One
https://www.readbyqxmd.com/read/28956837/predicting-the-global-potential-distribution-of-four-endangered-panax-species-in-middle-and-low-latitude-regions-of-china-by-the-geographic-information-system-for-global-medicinal-plants-gmpgis
#7
Zhixia Du, Jie Wu, Xiangxiao Meng, Jinhua Li, Linfang Huang
Global biodiversity is strongly influenced by the decrease in endangered biological species. Predicting the distribution of endangered medicinal plants is necessary for resource conservation. A spatial distribution model-geographic information system for global medicinal plants (GMPGIS)-is used to predict the global potential suitable distribution of four endangered Panax species, including Panax japonicas (T. Nees) C. A. Meyer and Panax japonicas var. major (Burkill) C. Y. Wu & K. M. Feng distributed in low- and middle-latitude, Panax zingiberensis C...
September 28, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28946190/p38-map-kinase-is-involved-in-oleuropein-induced-apoptosis-in-a549-cells-by-a-mitochondrial-apoptotic-cascade
#8
Shasha Cao, Xixi Zhu, Linfang Du
Lung cancer is one of malignant tumors that cause great threats to human health, which causes the fastest growing morbidity and mortality. Oleuropein as natural production exerts anticancer effects in several cancer cells. In the study, we investigated apoptotic effect of oleuropein on A549 cells and the underlying mechanisms. Oleuropein markedly decreased cell viability in A549 cells by resulting in G2/M phase arrest, but failed to decreased cell viability in BEAS-2B cells significantly. Apoptosis by oleuropein was confirmed by apoptotic morphology, accumulation in a sub-G1 peak, nucleus fragmentation and cleavage of PARP...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28945770/chemical-and-genetic-diversity-of-astragalus-mongholicus-grown-in-different-eco-climatic-regions
#9
Lin Li, Sihao Zheng, Josef A Brinckmann, Juan Fu, Rui Zeng, Linfang Huang, Shilin Chen
Astragalus mongholicus Bunge (Fabaceae) is an important plant source of the herbal drug known as Radix Astragali, which is used worldwide as a medicinal ingredient and a component of food supplement. Russian Federation, Mongolia, Kazakhstan, and China are the main natural distribution areas of A. mongholicus in the world. However, the quality of medicinal plant varies among different locations. As for A. mongholicus, limited literature focused on its biodiversity mechanism. Here, we combined the chemometric analysis of chemical components with genetic variation, as well as climatic and edaphic traits, to reveal the biodiversity mechanism of A...
2017: PloS One
https://www.readbyqxmd.com/read/28945464/transcriptome-profiling-of-clematis-apiifolia-insights-into-heat-stress-responses
#10
Lulu Gao, Yuzhu Ma, Peng Wang, Shu'an Wang, Rutong Yang, Qing Wang, Linfang Li, Ya Li
Clematis apiifolia, belonging to the Clematis L., is a woody vine native to China. It is characterized as heat resistant and fast growing. To better understand potential mechanisms involved in heat-stress responses in Clematis, we characterized the digital gene expression signatures of C. apiifolia under heat-stress conditions. Using RNA sequencing technology, we sequenced six libraries, three biological replicates of control samples and three of heat-stressed samples. In total, 61,708 unigenes were obtained, 36,447 (59...
November 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28892002/state-of-panax-ginseng-research-a-global-analysis
#11
REVIEW
Wanqi Xu, Hyung-Kyoon Choi, Linfang Huang
This article aims to understand the global and longitudinal trends of research on Panax ginseng. We used bibliometrics to analyze 3974 papers collected from the Web of Science(TM) Core Collection database during 1959-2016. The number of publications showed a steady growth before 2000 and exponentially increased in stage III (2000-2016, about 86% of the papers were published). Research on P. ginseng was conducted in 64 countries, mainly in Asia; in particular, 41% and 28% of the publications were from South Korea and China, respectively...
September 11, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28885057/plasticity-in-older-adults-theory-of-mind-performance-the-impact-of-motivation
#12
Xin Zhang, Serena Lecce, Irene Ceccato, Elena Cavallini, Linfang Zhang, Tianyong Chen
OBJECTIVE: Recently, motivation has been found to attenuate the age-related decline in Theory of Mind (ToM) performance (i.e. faux pas recognition). However, whether or not this effect could be generalized to other ToM tasks is still unknown. In the present study, we investigated whether and how motivation could enhance older adults' performance and reduce age differences in ToM tasks (Faux Pas vs. Animation task) that differ in familiarity. METHOD: Following a previous paradigm, 171 Chinese adults (87 younger adults and 84 older adults) were recruited, and we experimentally manipulated the level of perceived closeness between participants and the experimenter before administering the ToM tasks in order to enhance participants' motivation...
September 8, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28881608/anti-tumor-efficacy-of-theliatinib-in-esophageal-cancer-patient-derived-xenografts-models-with-epidermal-growth-factor-receptor-egfr-overexpression-and-gene-amplification
#13
Yongxin Ren, Jianming Zheng, Shiming Fan, Linfang Wang, Min Cheng, Dongxia Shi, Wei Zhang, Renxiang Tang, Ying Yu, Longxian Jiao, Jun Ni, Haibin Yang, Huaqing Cai, Fang Yin, Yunxin Chen, Feng Zhou, Weihan Zhang, Weiguo Qing, Weiguo Su
Targeted therapy is not yet approved for esophageal cancer (EC). In this study, we first evaluated EGFR gene and protein expression in 70 Chinese EC patient tumor samples collected during surgery. We then established 23 patient-derived EC xenograft (PDECX) models and assessed the efficacy of theliatinib, a potent and highly selective EGFR inhibitor currently in Phase I clinical study, in 9 PDECX models exhibiting various EGFR expression levels. Immunohistochemical analysis showed that 50 patient tumor samples (71...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28871449/arhgef39-promotes-gastric-cancer-cell-proliferation-and-migration-via-akt-signaling-pathway
#14
Haixiao Wang, Miaomiao Li, Xiaobao Tao, Yan Qian, Linfang Chen, Guoquan Tao
Dbl-family guanine nucleotide exchange factors (GEFs) can activate RhoGTPases by facilitating the exchange of GDP for GTP, the aberrant expression of which has been implicated in tumorigenicity and metastasis of human cancers. ARHGEF39, as a member of Dbl-family GEFs, was reported to be a potential oncogene in human hepatocellular carcinoma previously. However, the role of ARHGEF39 in gastric cancer (GC) remains unclear so far. In the current study, we demonstrated that ARHGEF39 expression was significantly upregulated in GC tissues compared with paired adjacent normal tissues by quantitative real-time PCR analysis...
September 4, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28760603/simultaneous-determination-of-intracellular-nucleotides-and-coenzymes-in-yarrowia-lipolytica-producing-lipid-and-lycopene-by-capillary-zone-electrophoresis
#15
Chen Zhao, Yan Yang, Linfang Wei, Qinghua Guo, Hao Fang, Shaolin Chen, Qiang Hua
Yarrowia lipolytica is an oleaginous yeast with promise in producing terpenoids such as lycopene. Though methods for analyzing primary metabolic intermediates have been established, further work is needed to better analyze nucleotides and coenzymes. Here, we presented an optimized method for the separation of nucleotides and coenzymes in Y. lipolytica using the capillary electrophoresis. The separation of twelve metabolites including four coenzymes, five nucleotides and three nucleosides was achieved within 32min using a voltage of 15kV and 70mM sodium carbonate/hydrogencarbonate buffer with 1...
July 24, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28754665/multiparametric-detection-of-antibodies-against-different-ebv-antigens-to-predict-risk-for-nasopharyngeal-carcinoma-in-a-high-risk-population-of-china
#16
Hao Chen, Shulin Chen, Jie Lu, Xueping Wang, Jianpei Li, Linfang Li, Jihuan Fu, Thomas Scheper, Wolfgang Meyer, Yu-Hui Peng, Wanli Liu
In this study, we aimed to use the combined detection of multiple antibodies against Epstein-Barr virus (EBV) antigens to develop a model for screening and diagnosis of nasopharyngeal carcinoma (NPC). Samples of 300 nasopharyngeal carcinoma patients and 494 controls, including 294 healthy subjects (HC), 99 non-nasopharyngeal carcinoma cancer patients (NNPC), and 101 patients with benign nasopharyngeal lesions (BNL), were incubated with the EUROLINE Anti-EBV Profile 2, and band intensities were used to establish a risk prediction model...
July 28, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28750900/virulence-of-an-h5n8-highly-pathogenic-avian-influenza-is-enhanced-by-the-amino-acid-substitutions-pb2-e627k-and-ha-a149v
#17
Haibo Wu, Xiuming Peng, Rufeng Lu, Lihua Xu, Fumin Liu, Linfang Cheng, Xiangyun Lu, Hangping Yao, Nanping Wu
A novel reassortant H5N8 highly pathogenic avian influenza (HPAI) virus was recently identified in Asia, Europe, and North America. The H5N8 HPAI virus has raised serious concerns regarding the potential risk for human infection. However, the molecular changes responsible for allowing mammalian infection in H5N8 HPAI viruses are not clear. The objective of this study was to identify amino acid substitutions that are potentially associated with the adaptation of H5N8 HPAI viruses to mammals. In this study, an avian-origin H5N8 virus was adapted to mice through serial lung-to-lung passage...
July 25, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28744301/three-dimensional-evaluation-on-ecotypic-diversity-of-traditional-chinese-medicine-a-case-study-of-artemisia-annua-l
#18
Lin Li, Brinckmann A Josef, Bing Liu, Sihao Zheng, Linfang Huang, Shilin Chen
Artemisinin is the first-line drug for anti-malaria recommended by the World Health Organization (WHO). As the sole natural plant source of artemisinin, ecotypes of Artemisia annua L. vary widely in artemisinin content between nations, and China is the main producing area of A. annua. Here we present a three-dimensional evaluation on ecotypic diversity of A. annua from 12 main producing areas in China using high-performance liquid chromatography coupled with evaporative light scattering detection (HPLC-ELSD) method, DNA barcoding and ecological analyses...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28730522/characterization-of-reassortant-h1-subtype-avian-influenza-viruses-isolated-from-poultry-in-zhejiang-province-in-china-from-2013-to-2015
#19
Haibo Wu, Rufeng Lu, Xiuming Peng, Fumin Liu, Linfang Cheng, Nanping Wu
From 2013 to 2015, 32 H1-subtype avian influenza viruses (AIVs), H1N2 (n = 12), H1N3 (n = 14), H1N4 (n = 4) and H1N9 (n = 2), were isolated from poultry in Zhejiang Province in eastern China. These strains were characterized by whole-genome sequencing with subsequent phylogenetic analysis and genetic comparison. Phylogenetic analysis of all eight viral genes showed that these strains clustered in the AIV Eurasian lineage. These strains were found to be minimally pathogenic in mice and were able to replicate in mice without prior adaptation...
November 2017: Archives of Virology
https://www.readbyqxmd.com/read/28698067/glycyrrhetinic-acid-modified-tpgs-polymeric-micelles-for-hepatocellular-carcinoma-targeted-therapy
#20
Xiumei Zhu, Altansukh Tsend-Ayush, Zhongyue Yuan, Jing Wen, Jiaxin Cai, Shifu Luo, Jianxu Yao, Junxing Bian, Linfang Yin, Jianping Zhou, Jing Yao
In this study, glycyrrhetinic acid (GA)-modified D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) polymeric micelles (TGA PMs) were developed for the delivery of etoposide (ETO) to hepatoma cells. GA was incorporated as a ligand because of its high affinity to the hepatocytes, while TPGS functioned as a P-gp inhibitor to reverse multidrug resistance. ETO-loaded TGA PMs (ETO-TGA PMs) displayed a mean particle size of 133.6±1.2nm with a low poly-dispersity index (0.224±0.013) and negative zeta potential (-16...
July 8, 2017: International Journal of Pharmaceutics
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