keyword
https://read.qxmd.com/read/38536926/surgical-tumor-derived-nanoplatform-targets-tumor-associated-macrophage-for-personalized-postsurgical-cancer-immunotherapy
#1
JOURNAL ARTICLE
Gongxi Qiao, Shenglin Li, Xumin Pan, Ping Xie, Ruixi Peng, Xiangrong Huang, Mengyun He, Jianhui Jiang, Xia Chu
Directly activating CD8+ T cells within the tumor through antigen-presenting cells (APCs) hold promise for tumor elimination. However, M2-like tumor-associated macrophages (TAMs), the most abundant APCs in tumors, hinder CD8+ T cell activation due to inefficient antigen cross-presentation. Here, we demonstrated a personalized nanotherapeutic platform using surgical tumor-derived galactose ligand-modified cancer cell membrane (CM)-coated cysteine protease inhibitor (E64)-loaded mesoporous silica nanoparticles for postsurgical cancer immunotherapy...
March 29, 2024: Science Advances
https://read.qxmd.com/read/38536692/towards-understanding-convergence-and-generalization-of-adamw
#2
JOURNAL ARTICLE
Pan Zhou, Xingyu Xie, Zhouchen Lin, Shuicheng Yan
AdamW modifies Adam by adding a decoupled weight decay to decay network weights per training iteration. For adaptive algorithms, this decoupled weight decay does not affect specific optimization steps, and differs from the widely used l2 -regularizer which changes optimization steps via changing the first- and second-order gradient moments. Despite its great practical success, for AdamW, its convergence behavior and generalization improvement over Adam and l2 -regularized Adam ( l2 -Adam) remain absent yet...
March 27, 2024: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://read.qxmd.com/read/38536640/genetically-predicted-apolipoprotein-e-levels-with-the-risk-of-panvascular-diseases-a-mendelian-randomization-study
#3
JOURNAL ARTICLE
Yi-Ming Shi, Dian Ou, Jia-Ting Li, Le Bao, Xiao-Dan Liu, Wei Zhang, Huang Ding
The aim of this study was to comprehensively assess the causal relationship between the overall genetic effect of circulating ApoE levels and panvascular lesions using newer genome-wide association data and two-sample bidirectional Mendelian randomization (MR) analysis. Two-way MR using single-nucleotide polymorphisms of circulating ApoE as instrumental variables was performed using the highest-priority Genome-wide association study (GWAS) data, with factor-adjusted and data-corrected statistics, to estimate causal associations between circulating ApoE levels and 10 pan-vascular diseases in > 500,000 UK Biobank participants, > 400,000 participants of Finnish ancestry, and numerous participants in a consortium of predominantly European ancestry...
March 27, 2024: Cardiovascular Toxicology
https://read.qxmd.com/read/38536624/validation-of-the-visionarray%C3%A2-chip-assay-for-hpv-dna-testing-in-histology-specimens-of-oropharyngeal-squamous-cell-carcinoma
#4
JOURNAL ARTICLE
Hani Ibrahim Channir, Simone Kloch Bendtsen, Linea Cecilie Melchior, Pia Rovsing Sandholm, Christine Mordhorst, Amanda-Louise Fenger Carlander, Christian von Buchwald, Katalin Kiss
BACKGROUND: The detection of human papillomavirus (HPV) has several implications in the diagnostic work-up and management of oropharyngeal squamous cell carcinoma (OPSCC). The choice of HPV detection assay and testing algorithms differ across institutions and vary in cost, detection targets, technical feasibility, and turnaround time. In this study, we aimed to validate the VisionArray® HPV Chip for formalin-fixed and paraffin-embedded (FFPE) samples of OPSCC using the previously applied standard pan-HPV DNA PCR assay as a reference...
March 27, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38536595/identification-novel-mutations-and-phenotypic-spectrum-expanding-in-patl2-in-infertile-women-with-ivf-icsi-failure
#5
JOURNAL ARTICLE
Zhiqi Ye, Da Li, Xiangli Niu, Aimin Yang, Zhiqi Pan, Ran Yu, Hao Gu, Rong Shi, Ling Wu, Yanfang Xiang, Guimin Hao, Yanping Kuang, Biaobang Chen, Lei Wang, Qing Sang, Lin Li, Juanzi Shi, Qiaoli Li
AIM: Abnormalities in oocyte maturation, fertilization, and early embryonic development are major causes of primary infertility in women who are undergoing IVF/ICSI attempts. Although many genetic factors responsible for these abnormal phenotypes have been identified, there are more additional pathogenic genes and variants yet to be discovered. Previous studies confirmed that bi-allelic PATL2 deficiency is an important factor for female infertility. In this study, 935 infertile patients with IVF/ICSI failure were selected for whole-exome sequencing, and 18 probands carrying PATL2 variants with a recessive inheritance pattern were identified...
March 27, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38536593/altered-grooming-cycles-in-transgenic-drosophila
#6
JOURNAL ARTICLE
John M Ringo, Daniel Segal
Head grooming in Drosophila consists of repeated sweeps of the legs across the head, comprising regular cycles. We used the GAL4-UAS system to study the effects of overexpressing shibirets1 and of Adar knockdown via RNA interference, on the period of head-grooming cycles in Drosophila. Overexpressing shibirets1 interferes with synaptic vesicle recycling and thus with cell communication, while Adar knockdown reduces RNA editing of neuronal transcripts for a large number of genes. All transgenic flies and their controls were tested at 22° to avoid temperature effects; in wild type, cycle frequency varied with temperature with a Q10 of 1...
March 27, 2024: Behavior Genetics
https://read.qxmd.com/read/38536581/diagnostic-performance-of-ultrasound-in-the-assessment-of-gastric-contents-a-meta-analysis-and-systematic-review
#7
REVIEW
Xuanyuan Pan, Jun Chai, Xin Gao, Si Li, Jie Liu, Linxing Li, Yanjing Li, Zhichao Li
OBJECTIVE: To systematically analyze the accuracy of ultrasonic techniques in assessing the nature of gastric contents and their volume. METHODS: English-language articles that used ultrasonic techniques to assess the nature of gastric contents and their volume in patients were selected. In eligible studies, data were recalculated and analyzed for forest plots and subject summary curves of operating characteristics (SROC). Study quality was assessed using the diagnostic accuracy study quality assessment tool QUADAS-2...
March 27, 2024: Insights Into Imaging
https://read.qxmd.com/read/38536553/vrk1-promotes-dna-induced-type-i-interferon-production
#8
JOURNAL ARTICLE
Zhechen Fan, Xiong Wang, Hao Cheng, Mingyu Pan
BACKGROUND: Type I interferons (IFNs) are an essential class of cytokines with antitumor, antiviral and immunoregulatory effects. However, over-productive the type I IFNs are tightly associated with autoimmune disorders. Thus, the induction of type I interferons is precisely regulated to maintain immune hemostasis. This study aimed to identify a novel regulator of type I interferon signaling. METHODS AND RESULTS: Primary BMDMs, isolated from mice, and human cell lines (HEK293 cells, Hela cells) and murine cell line (MEF cells) were cultured to generate in vitro models...
March 27, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38536548/bone-mineral-density-in-adults-growth-hormone-deficiency-with-different-ages-of-onset-a-real-world-retrospective-study
#9
JOURNAL ARTICLE
Hongbo Yang, Meiping Chen, Hanyuan Xu, Yunfeng Zhen, Yuelun Zhang, Linjie Wang, Lian Duan, Fengying Gong, Huijuan Zhu, Hui Pan
PURPOSE: Bone mineral density (BMD) impairment is one of the critical factors for long-term quality of life in adults growth hormone deficiency (AGHD). This study aims to investigate the annual changes in BMD in AGHD patients with different ages of onset and to identify predicting factors that influence BMD. METHODS: AGHD patients (n = 160) with available data for 4 years follow-up from a major tertiary medical center in China were retrospectively included (110 [68...
March 27, 2024: Endocrine
https://read.qxmd.com/read/38536537/correction-a-hybrid-pragmatic-and-factorial-cluster-randomized-controlled-trial-for-an-anti-racist-multilevel-intervention-to-improve-mental-health-equity-in-high-schools
#10
Marta I Mulawa, Sharron L Docherty, Donald E Bailey, Rosa M Gonzalez-Guarda, Isaac M Lipkus, Schenita D Randolph, Qing Yang, Wei Pan
No abstract text is available yet for this article.
March 27, 2024: Prevention Science: the Official Journal of the Society for Prevention Research
https://read.qxmd.com/read/38536525/correction-to-added-diagnostic-value-of-16s-rrna-gene-pan-mycobacterial-pcr-for-nontuberculous-mycobacterial-infections-a-10-year-retrospective-study
#11
Simon Andenmatten, Onya Opota, Jessica Mazza-Stalder, Laurent Nicod, Gilbert Greub, Katia Jaton
No abstract text is available yet for this article.
March 27, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38536078/genetic-associations-between-circulating-immune-cells-and-periodontitis-highlight-the-prospect-of-systemic-immunoregulation-in-periodontal-care
#12
JOURNAL ARTICLE
Xinjian Ye, Yijing Bai, Mengjun Li, Yuhang Ye, Yitong Chen, Bin Liu, Yuwei Dai, Shan Wang, Weiyi Pan, Zhiyong Wang, Yingying Mao, Qianming Chen
Periodontitis drives irreversible destruction of periodontal tissue and is prone to exacerbating inflammatory disorders. Systemic immunomodulatory management continues to be an attractive approach in periodontal care, particularly within the context of 'predictive, preventive, and personalized' periodontics. The present study incorporated genetic proxies identified through genome-wide association studies for circulating immune cells and periodontitis into a comprehensive Mendelian randomization (MR) framework...
March 27, 2024: ELife
https://read.qxmd.com/read/38536037/effects-of-follicle-stimulating-hormone-on-energy-balance-and-tissue-metabolic-health-after-loss-of-ovarian-function
#13
JOURNAL ARTICLE
Andrew E Libby, Claudia Solt, Matthew Jackman, Vanessa Sherk, Rebecca M Foright, Ginger C Johnson, Thi-Tina Nguyen, Matthew Breit, Nicholas Hulett, Michael Rudolph, Paul A Roberson, Elizabeth Wellberg, Purevsuren Jambal, Rebecca L Scalzo, Janine Higgins, T Rajendra Kumar, Margaret E Wierman, Zhaoxing Pan, Kartik Shankar, Dwight J Klemm, Kerrie L Moreau, Wendy M Kohrt, Paul S MacLean
Loss of ovarian function imparts increased susceptibility to obesity and metabolic disease. These effects are largely attributed to decreased estradiol (E2 ), but the role of increased follicle stimulating hormone (FSH) in modulating energy balance has not been fully investigated. Previous work that blocked FSH binding to its receptor in mice suggested this hormone may play a part in modulating body weight and energy expenditure after ovariectomy. We used an alternate approach to isolate the individual and combined contributions of FSH and E2 in mediating energy imbalance and changes in tissue-level metabolic health...
March 27, 2024: American Journal of Physiology. Endocrinology and Metabolism
https://read.qxmd.com/read/38536004/psychometric-properties-of-the-pans-31-item-symptom-rating-scale
#14
JOURNAL ARTICLE
Gail A Bernstein, Maroof H Khan, Rebecca L Freese, Cindy Manko, Melissa Silverman, Sana Ahmed, Bahare Farhadian, Meiqian Ma, Margo Thienemann, Tanya K Murphy, Jennifer Frankovich
Objectives: Pediatric acute-onset neuropsychiatric syndrome (PANS) is characterized by sudden onset of obsessive-compulsive disorder and/or eating restriction with associated neuropsychiatric symptoms from at least two of seven categories. The PANS 31-Item Symptom Rating Scale (PANS Rating Scale) was developed to identify and measure the severity of PANS symptoms. The objective of this study was to define the psychometric properties of the PANS Rating Scale. Methods: Children with PANS ( N  = 135) and their parents participated...
March 27, 2024: Journal of Child and Adolescent Psychopharmacology
https://read.qxmd.com/read/38536000/the-role-of-working-conditions-in-educational-differences-in-all-cause-and-ischemic-heart-disease-mortality-among-swedish-men
#15
JOURNAL ARTICLE
Melody Almroth, Tomas Hemmingsson, Daniel Falkstedt, Katarina Kjellberg, Emma Carlsson, Kuan-Yu Pan, Karin Berglund, Emelie Thern
OBJECTIVES: This study aims to investigate the extent to which low job control and heavy physical workload in middle age explain educational differences in all-cause and ischemic heart disease (IHD) mortality while accounting for important confounding factors. METHODS: The study is based on a register-linked cohort of men who were conscripted into the Swedish military at around the age of 18 in 1969/1970 and were alive and registered in Sweden in 2005 (N=46 565)...
March 27, 2024: Scandinavian Journal of Work, Environment & Health
https://read.qxmd.com/read/38535996/proteomic-analysis-of-human-saliva-via-solid-phase-microextraction-coupled-with-liquid-chromatography-mass-spectrometry
#16
JOURNAL ARTICLE
Runshan W Jiang, Lina M Marin, Karol Jaroch, Wei Zhou, Walter L Siqueira, Janusz Pawliszyn
Proteomics of human saliva samples was achieved for the first time via biocompatible solid-phase microextraction (bio-SPME) devices. Upon introduction of a porogen to a conventional C18 coating, porous C18/polyacrylonitrile (PAN) SPME blades were able to extract peptides up to 3.0 kDa and more peptides than commercial SPME blades. Following Trypsin digestion, salivary proteomic analysis was achieved via SPME-LC-MS/MS. Seven endogenous proteins were consistently identified in all saliva samples via bio-SPME...
March 27, 2024: Analytical Chemistry
https://read.qxmd.com/read/38535949/editorial-for-the-special-issue-environmental-exposure-and-reproductive-health
#17
EDITORIAL
Pan Yang
In recent decades, the decline in human fertility has emerged as a significant public health concern, garnering global attention [...].
March 14, 2024: Toxics
https://read.qxmd.com/read/38535826/exploration-of-cytochrome-p450-related-interactions-between-aflatoxin-b1-and-tiamulin-in-broiler-chickens
#18
JOURNAL ARTICLE
Pan Sun, Orphélie Lootens, Tadele Kabeta, Diethard Reckelbus, Natalia Furman, Xingyuan Cao, Suxia Zhang, Gunther Antonissen, Siska Croubels, Marthe De Boevre, Sarah De Saeger
Poultry may face simultaneous exposure to aflatoxin B1 (AFB1) and tiamulin (TIA), given mycotoxin contamination and antibiotic use. As both mycotoxins and antibiotics can affect cytochrome P450 enzymes (CYP450), our study aimed to explore their interaction. We developed UHPLC-MS/MS methods for the first-time determination of the interaction between TIA and AFB1 in vitro and in vivo in broiler chickens. The inhibition assay showed the half maximal inhibitory concentration (IC50 ) values of AFB1 and TIA in chicken liver microsomes are more than 7...
March 20, 2024: Toxins
https://read.qxmd.com/read/38535776/chelating-additive-regulating-zn-ion-solvation-chemistry-for-highly-efficient-aqueous-zinc-metal-battery
#19
JOURNAL ARTICLE
Dongming Xu, Xueting Ren, Haoyu Li, Yuran Zhou, Simin Chai, Yining Chen, Hang Li, Lishun Bai, Zhi Chang, Anqiang Pan, Haoshen Zhou
Aqueous zinc-metal batteries (AZMBs) usually suffered from poor reversibility and limited lifespan because of serious water induced side-reactions, hydrogen evolution reactions (HER) and rampant zinc (Zn) dendrite growth. Reducing the content of water molecules within Zn-ion solvation sheaths can effectively suppress those inherent defects of AZMBs. In this work, we originally discovered that the two carbonyl groups of N-Acetyl-ε-caprolactam (N-ac) chelating ligand can serve as dual solvation sites to coordinate with Zn2+, thereby minimizing water molecules within Zn-ion solvation sheaths, and greatly inhibit water-induced side-reactions and HER...
March 27, 2024: Angewandte Chemie
https://read.qxmd.com/read/38535768/myocardial-strain-for-the-differentiation-of-myocardial-involvement-in-the-post-acute-sequelae-of-covid-19-a-multiparametric-cardiac-mri-study
#20
JOURNAL ARTICLE
El-Sayed H Ibrahim, Jason Rubenstein, Antonio Sosa, Jadranka Stojanovska, Amy Pan, Paula North, Hallgeir Rui, Ivor Benjamin
Myocardial involvement was shown to be associated with an unfavorable prognosis in patients with COVID-19, which could lead to fatal outcomes as in myocardial injury-induced arrhythmias and sudden cardiac death. We hypothesized that magnetic resonance imaging (MRI) myocardial strain parameters are sensitive markers for identifying subclinical cardiac dysfunction associated with myocardial involvement in the post-acute sequelae of COVID-19 (PASC). This study evaluated 115 subjects, including 65 consecutive COVID-19 patients, using MRI for the assessment of either post-COVID-19 myocarditis or other cardiomyopathies...
February 27, 2024: Tomography: a Journal for Imaging Research
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