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https://www.readbyqxmd.com/read/29156873/prevention-of-propofol-injection-related-pain-using-pretreatment-transcutaneous-electrical-acupoint-stimulation
#1
Luping Huang, Yuanyuan Pan, Sijia Chen, Münyuan Zhang, Xiuxiu Zhuang, Shenhui Jin, Junlu Wang, Qinxue Dai, Yunchang Mo
Background/aim: This study aimed to study the effect of pretreatment transcutaneous electrical acupoint stimulation (TEAS) in preventing propofol injection-related pain. Materials and methods: A total of 360 patients who were to undergo elective hysteroscopy surgery were randomly divided into the following three groups of 120 patients each: control (Group C), sham TEAS (Group F), and TEAS (Group T). Patients in Group C did not undergo any treatment before surgery; 30 min before the induction of anesthesia, patients in Groups F and T underwent electrical stimulation of the bilateral LI4-PC6 acupoint...
August 23, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29156803/tet1-inhibits-cell-proliferation-by-inducing-rassf5-expression
#2
Bo-Tai Li, Chao Yu, Ying Xu, Sheng-Bing Liu, Heng-Yu Fan, Wei-Wei Pan
Tet methylcytosine dioxygenases (TETs) catalyze the oxidative reactions of 5-methylcytosine to 5-hydroxymethylcytosine (5hmC). However, TET1 roles in ovarian cancer cell growth are unknown. Here, we show that ectopic expression of TET1 increased 5hmC levels, and inhibited proliferation and colony formation in ovarian cancer cell lines. Furthermore, in vitro and in vivo functional studies demonstrated that TET1 overexpression is necessary for the suppression of ovarian cancer growth, whereas depletion of TET1 expression had the opposite effect...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156721/a-hemoglobin-based-oxygen-carrier-sensitized-cisplatin-based-chemotherapy-in-hepatocellular-carcinoma
#3
Xiang Qi, Bing L Wong, Sze Hang Lau, Kevin Tak-Pan Ng, Sui Yi Kwok, Chris Kin-Wai Sun, Fei Chuen Tzang, Yan Shao, Chang Xian Li, Wei Geng, Chang Chun Ling, Yuen Yuen Ma, Xiao Bing Liu, Hui Liu, Jiang Liu, Wai Ho Yeung, Chung Mau Lo, Kwan Man
Background and Objective: Our previous study showed that liver graft injury not only promotes tumor recurrence, but also induces chemoresistance in recurrent HCC after liver transplantation. Recently, we found that the hemoglobin-based oxygen carrier"YQ23" significantly ameliorates hepatic IR injury and prevent tumor recurrence. Here, we intended to explore the novel therapeutic strategy using oxygen carrier "YQ23"to sensitize chemotherapy in HCC. Methods: To investigate the role of YQ23 combined with Cisplatin, the proliferation of HCC cells was examined under combined treatment by MTT and colony formation...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156674/novel-combinations-of-pi3k-mtor-inhibitors-with-dacomitinib-or-chemotherapy-in-pten-deficient-patient-derived-tumor-xenografts
#4
Irene Brana, Nhu-An Pham, Lucia Kim, Shingo Sakashita, Ming Li, Christine Ng, Yuhui Wang, Peter Loparco, Rafael Sierra, Lisa Wang, Blaise A Clarke, Benjamin G Neel, Lillian L Siu, Ming-Sound Tsao
PTEN inactivation occurs commonly in human cancers and putatively activates the PI3K/AKT/ mTOR pathway. Activation of this pathway has been involved in resistance to chemotherapy or anti-EGFR/HER2 therapies. We evaluated the combination of PI3K-mTOR inhibitors with chemotherapy or the pan-HER inhibitor dacomitinib in PTEN-deficient patient-derived tumor xenografts (PDX). Three PDXs were selected for their lack of PTEN expression by immunohistochemistry: a triple-negative breast cancer (TNBC), a KRAS G12R low-grade serous ovarian cancer (LGSOC), and KRAS G12C and TP53 R181P lung adenocarcinoma (LADC)...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156621/influence-of-shenxiong-glucose-injection-on-the-activities-of-six-cyp-isozymes-and-metabolism-of-warfarin-in-rats-assessed-using-probe-cocktail-and-pharmacokinetic-approaches
#5
Jia Sun, Yuan Lu, Yueting Li, Jie Pan, Chunhua Liu, Zipeng Gong, Jing Huang, Jiang Zheng, Lin Zheng, Yongjun Li, Ting Liu, Yonglin Wang
Shenxiong glucose injection (SGI), a traditional Chinese medicine (TCM) preparation, has been widely used for the treatment of various cardiovascular and cerebrovascular diseases for many years. We assessed the potential influences of SGI on the activities of six CYP enzymes (CYP1A2, CYP2C11, CYP2C19, CYP2D4, CYP2E1, and CYP3A2) and on the pharmacokinetics of warfarin in rats. We compared plasma pharmacokinetics of six probe drugs (caffeine/CYP1A2, tolbutamide/CYP2C11, omeprazole/CYP2C19, metoprolol/CYP2D4, chlorzoxazone/CYP2E1, and midazolam/CYP3A2) and of warfarin between control and SGI-pretreated groups, to estimate the effect on the relative activities of the six isozymes and warfarin metabolism...
November 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29156585/pan-cellulosomics-of-mesophilic-clostridia-variations-on-a-theme
#6
Bareket Dassa, Ilya Borovok, Vincent Lombard, Bernard Henrissat, Raphael Lamed, Edward A Bayer, Sarah Moraïs
The bacterial cellulosome is an extracellular, multi-enzyme machinery, which efficiently depolymerizes plant biomass by degrading plant cell wall polysaccharides. Several cellulolytic bacteria have evolved various elaborate modular architectures of active cellulosomes. We present here a genome-wide analysis of a dozen mesophilic clostridia species, including both well-studied and yet-undescribed cellulosome-producing bacteria. We first report here, the presence of cellulosomal elements, thus expanding our knowledge regarding the prevalence of the cellulosomal paradigm in nature...
November 18, 2017: Microorganisms
https://www.readbyqxmd.com/read/29156517/mir-504-inhibits-cell-proliferation-and-invasion-by-targeting-loxl2-in-non-small-cell-lung-cancer
#7
Ming-Fan Ye, Ji-Guang Zhang, Tian-Xing Guo, Xiao-Jie Pan
BACKGROUND: MicroRNAs (miRNAs) play crucial roles in tumor initiation and development. The aim of the study was to explore the clinicopathological role and functional effects of miR-504 in non small cell lung cancer (NSCLC). METHODS: Quantitative reverse transcription polymerase chain reaction (QRT-PCR) was applied to detect the expression of miR-504 in 55 cases of NSCLC tissues and matched adjacent normal tissues in NSCLC patients. MTT, colony formation and transwell invasion assays were performed to evaluate the effects of miR-504 on cell proliferation and invasion, respectively...
November 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29156392/biofilms-as-a-sink-for-antibiotic-resistance-genes-args-in-the-yangtze-estuary
#8
Xing-Pan Guo, Yi Yang, Da-Pei Lu, Zuo-Shun Niu, Jing-Nan Feng, Yu-Ru Chen, Fei-Yun Tou, Emily Garner, Jiang Xu, Min Liu, Michael F Hochella
Biofilms are ubiquitous throughout aquatic environments and they are thought to promote the acquisition and dissemination of antibiotic resistant genes (ARGs). This study focused on the occurrence and distribution of five types of ARG in naturally-occurring biofilms, in comparison to associated sediment and water samples, from the Yangtze Estuary, which borders the meta-city of Shanghai, China. The detection frequency and abundances of most ARGs showed the following order: biofilm > sediment > water, which can be attributed to a high level of antibiotics and metals that can accelerate the generation and propagation of ARGs in biofilms...
November 13, 2017: Water Research
https://www.readbyqxmd.com/read/29156097/4-aminopyridine-a-pan-kv-channel-inhibitor-that-enhances-kv7-4-currents-and-inhibits-noradrenaline-mediated-contraction-of-rat-mesenteric-small-arteries
#9
Makhala M Khammy, Sukhan Kim, Bo H Bentzen, Soojung Lee, Inyeoung Choi, Christian Aalkjaer, Thomas A Jepps
BACKGROUND AND PURPOSE: Kv7.4 and Kv7.5 channels are regulators of vascular tone. 4-aminopyridine (4-AP) is considered a broad inhibitor of voltage-gated potassium (KV ) channels, with little inhibitory effect on Kv7 family members at millimolar concentrations. However, the effect of 4-AP on Kv7 channels has not been systematically studied. The aim of this study was to investigate the pharmacological activity of 4-AP on Kv7.4 and Kv7.5 channels and characterise the effect of 4-AP on rat resistance arteries...
November 20, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29155929/pan-asian-adapted-esmo-consensus-guidelines-for-the-management-of-patients-with-metastatic-colorectal-cancer-a-jsmo-esmo-initiative-endorsed-by-csco-kaco-mos-sso-and-tos
#10
T Yoshino, D Arnold, H Taniguchi, G Pentheroudakis, K Yamazaki, R-H Xu, T W Kim, F Ismail, I B Tan, K-H Yeh, A Grothey, S Zhang, J B Ahn, D Chong, L-T Chen, S Kopetz, T Eguchi-Nakajima, H Ebi, A Ohtsu, A Cervantes, K Muro, J Tabernero, H Minami, F Ciardiello, J-Y Douillard
The most recent version of the European Society for Medical Oncology (ESMO) consensus guidelines for the treatment of patients with metastatic colorectal cancer (mCRC) was published in 2016, identifying both a more strategic approach to the administration of the available systemic therapy choices, and a greater emphasis on the use of ablative techniques, including surgery. At the 2016 ESMO Asia Meeting, in December 2016, it was decided by both ESMO and the Japanese Society of Medical Oncology (JSMO) to convene a special guidelines meeting, endorsed by both ESMO and JSMO, immediately after the JSMO 2017 Annual Meeting...
November 16, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29155878/irhom2-is-essential-for-innate-immunity-to-rna-virus-by-antagonizing-er-and-mitochondria-associated-degradation-of-visa
#11
Wei-Wei Luo, Shu Li, Chen Li, Zhou-Qin Zheng, Pan Cao, Zhen Tong, Huan Lian, Su-Yun Wang, Hong-Bing Shu, Yan-Yi Wang
VISA (also known as MAVS, IPS-1 and Cardif) is an essential adaptor protein in innate immune response to RNA virus. The protein level of VISA is delicately regulated before and after viral infection to ensure the optimal activation and timely termination of innate antiviral response. It has been reported that several E3 ubiquitin ligases can mediate the degradation of VISA, but how the stability of VISA is maintained before and after viral infection remains enigmatic. In this study, we found that the ER-associated inactive rhomboid protein 2 (iRhom2) plays an essential role in mounting an efficient innate immune response to RNA virus by maintaining the stability of VISA through distinct mechanisms...
November 20, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29155677/expanding-pertussis-epidemiology-in-6-latin-america-countries-through-the-latin-american-pertussis-project
#12
Veronica A Pinell-McNamara, Anna M Acosta, Maria Cristina Pedreira, Ana F Carvalho, Lucia Pawloski, Maria Lucia Tondella, Elizabeth Briere
The Latin American Pertussis Project (LAPP), established in 2009, is a collaboration between the Centers for Disease Control and Prevention, Pan American Health Organization, Sabin Vaccine Institute, and the ministries of health of 6 countries in Latin America. The project goal is to expand understanding of pertussis epidemiology in Latin America to inform strategies for control and prevention. Here we describe LAPP structure and activities. After an initial surveillance evaluation, LAPP activities are tailored to individual country needs...
December 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29155641/pulsed-focused-ultrasound-stimulates-the-release-of-tumor-biomarkers-into-the-blood-circulation
#13
Hong Pan, Wenbin Zhou, Shui Wang
No abstract text is available yet for this article.
December 2017: Radiology
https://www.readbyqxmd.com/read/29155541/a-festive-case-series-of-emergencies-admissions-and-friendship-at-a-busy-oral-and-maxillofacial-unit
#14
Ross Keat, Paul Leavy, Mathew Thomas
The festive season presents oral and maxillofacial surgery (OMFS) dental core trainees (DCTs) with the challenges of managing an eclectic mix of emergencies. We present three such patients in this case series. First, Patient A, a 39-year-old homeless male who presented with a maxillary extra-oral draining sinus. Secondly, Patient B, a 38-year-old intra-venous (IV) drug user who suffered pan-facial fractures following an alcohol-fuelled assault. Finally, Patient C, a 38-year-old male who sustained a left zygomatic complex fracture a week previously, in attendance for corrective surgery...
December 2016: Dental Update
https://www.readbyqxmd.com/read/29155487/novel-cyp6d1-and-voltage-gated-sodium-channel-alleles-of-the-house-fly-musca-domestica-and-their-roles-in-pyrethroid-resistance
#15
Jing Pan, Chan Yang, Yan Liu, Qi Gao, Mei Li, Xinghui Qiu
BACKGROUND: The house fly Musca domestica is an important disease vector. Point mutation mediated target-site insensitivity of the voltage gated sodium channel (VSSC) and increased detoxification mediated by CYP6D1 overexpression have been characterized to be two major mechanisms of pyrethroid resistance. In this study, genetic mutations in Vssc and CYP6D1 genes and their contribution to pyrethroid resistance were investigated. RESULTS: Twelve lines of house flies homozygous for four genotypes were established...
November 20, 2017: Pest Management Science
https://www.readbyqxmd.com/read/29155453/large-scale-bleaching-of-corals-on-the-great-barrier-reef
#16
T P Hughes, J T Kerry, T Simpson
In 2015-2016, record temperatures triggered a pan-tropical episode of coral bleaching. In the southern hemisphere summer of March-April 2016, we used aerial surveys to measure the level of bleaching on 1,156 individual reefs throughout the 2,300 km length of the Great Barrier Reef, the world's largest coral reef system. The accuracy of the aerial scores was ground-truthed with detailed underwater surveys of bleaching at 260 sites (104 reefs), allowing us to compare aerial and underwater bleaching data with satellite-derived temperatures and with associated model predictions of bleaching...
November 20, 2017: Ecology
https://www.readbyqxmd.com/read/29155199/physiochemical-and-functional-properties-of-tiger-puffer-takifugu-rubripes-skin-gelatin-as-affected-by-extraction-conditions
#17
Jinfeng Pan, Qi Li, Hui Jia, Lining Xia, Wengang Jin, Meijun Shang, Chang Xu, Xiuping Dong
The study investigated physiochemical and functional properties of gelatins from tiger puffer skin (GTPS) extracted with warm-water method at 45, 55 and 65°C for 3, 6 and 12h. GTPS45 exhibited strong γ-, β-, α1- and α2-chains, but they faded with the presence of fragments (<80 KDa) in other GTPS. As the increase of temperature and time, amide I and A were shifted to higher wavenumber and their amplitudes in GTPS65-12 decreased. Lightness declined while redness and yellowness were enhanced. Gel strength was in a range of 144...
November 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29155198/immunomodulating-activity-of-the-polysaccharide-tlh-3from-tricholomalobayense-in-raw264-7-macrophages
#18
Mingzhu Zhang, Xiaohe Tian, Ya Wang, Dandan Wang, Wan Li, Lei Chen, Wenjun Pan, Shomaila Mehmood, Yan Chen
Polysaccharide TLH-3 extracted from Tricholoma lobayense possessed unique antioxidant and anti-aging activities, whereas its immunomodulatory properties remain unexplored. Herein in order to explore TLH-3 biological activities, the immunomodulatory effects on RAW264.7 macrophages and its molecular mechanisms were investigated. It was showed that TLH-3 could significantly enhance the phagocytic activity, releasing toxic molecules NO (nitricoxide), secretion of the cytokine TNF-?(tumor necrosis factor-?, IL-6 (interleukin-6)...
November 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29155100/defects-in-plasma-cell-differentiation-is-associated-with-primary-immunodeficiency-in-humans
#19
EDITORIAL
Qiang Pan-Hammarström, Hassan Abolhassani, Lennart Hammarström
No abstract text is available yet for this article.
November 15, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29155028/chitosan-oligosaccharides-with-degree-of-polymerization-2-6-induces-apoptosis-in-human-colon-carcinoma-hct116%C3%A2-cells
#20
Pan Zou, Shoujun Yuan, Xin Yang, Xingchen Zhai, Jing Wang
Colon cancer is the third most common cancer, and yet there is a lack of effective therapeutic methods with low side effects. Chitosan oligosaccharides (COS) is derived from chitosan after chitin deacetylation, and attracts more interests due to smaller molecular weight and soluble property. Previously, COS, mainly absorbed through intestinal epithelia, has been reported to exhibit many bioactivities, especially its anti-tumor effect. Recent references pay little attention to molecular weight distribution which is crucial for understanding its biological behavior...
November 16, 2017: Chemico-biological Interactions
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