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compulsive obsessive disorders

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https://www.readbyqxmd.com/read/29220783/a-study-to-compare-the-differences-between-genders-in-psychiatric-comorbidities-in-individuals-with-psychoses
#1
Praveen Das, Priya Sreedaran, Ashok Mv
BACKGROUND: Psychiatric comorbidities worsen the outcome and increase severity of suffering in psychotic disorders. Gender differences have also been found to impact the severity and outcome in psychoses. In this background, this study attempted to compare psychiatric comorbidity between genders. AIMS AND OBJECTIVES: The aim was to compare psychiatric co-morbidity between men and women with psychotic disorders. METHODOLOGY: A descriptive cross sectional study design was used...
November 29, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29217994/local-fields-in-human-subthalamic-nucleus-track-the-lead-up-to-impulsive-choices
#2
John M Pearson, Patrick T Hickey, Shivanand P Lad, Michael L Platt, Dennis A Turner
The ability to adaptively minimize not only motor but cognitive symptoms of neurological diseases, such as Parkinson's Disease (PD) and obsessive-compulsive disorder (OCD), is a primary goal of next-generation deep brain stimulation (DBS) devices. On the basis of studies demonstrating a link between beta-band synchronization and severity of motor symptoms in PD, the minimization of beta band activity has been proposed as a potential training target for closed-loop DBS. At present, no comparable signal is known for the impulsive side effects of PD, though multiple studies have implicated theta band activity within the subthalamic nucleus (STN), the site of DBS treatment, in processes of conflict monitoring and countermanding...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29215777/atypical-anorexia-nervosa-is-not-related-to-brain-structural-changes-in-newly-diagnosed-adolescent-patients
#3
Gaia Olivo, Linda Solstrand Dahlberg, Lyle Wiemerslage, Ingemar Swenne, Christina Zhukovsky, Helena Salonen-Ros, Elna-Marie Larsson, Santino Gaudio, Samantha J Brooks, Helgi B Schiöth
OBJECTIVE: Patients with atypical anorexia nervosa (AN) have many features overlapping with AN in terms of genetic risk, age of onset, psychopathology and prognosis of outcome, although the weight loss may not be a core factor. While brain structural alterations have been reported in AN, there are currently no data regarding atypical AN patients. METHOD: We investigated brain structure through a voxel-based morphometry analysis in 22 adolescent females newly-diagnosed with atypical AN, and 38 age- and sex-matched healthy controls (HC)...
December 7, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/29214602/peromyscus-maniculatus-bairdii-as-a-naturalistic-mammalian-model-of-obsessive-compulsive-disorder-current-status-and-future-challenges
#4
De Wet Wolmarans, Isabella M Scheepers, Dan J Stein, Brian H Harvey
Obsessive-compulsive disorder (OCD) is a prevalent and debilitating condition, characterized by intrusive thoughts and repetitive behavior. Animal models of OCD arguably have the potential to contribute to our understanding of the condition. Deer mice (Permomyscus maniculatus bairdii) are characterized by stereotypic behavior which is reminiscent of OCD symptomology, and which may serve as a naturalistic animal model of this disorder. Moreover, a range of deer mouse repetitive behaviors may be representative of different compulsive-like phenotypes...
December 6, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29213280/subthreshold-psychiatric-psychopathology-in-functional-gastrointestinal-disorders-can-it-be-the-bridge-between-gastroenterology-and-psychiatry
#5
Cristina Stasi, Cristiana Nisita, Sonia Cortopassi, Giorgio Corretti, Dario Gambaccini, Nicola De Bortoli, Bernardo Fani, Natalia Simonetti, Angelo Ricchiuti, Liliana Dell'Osso, Santino Marchi, Massimo Bellini
Background and Aims: Functional gastrointestinal disorders (FGDs) are multifactorial disorders of the gut-brain interaction. This study investigated the prevalence of Axis I and spectrum disorders in patients with FGD and established the link between FGDs and psychopathological dimensions. Methods: A total of 135 consecutive patients with FGD were enrolled. The symptoms' severity was evaluated using questionnaires, while the psychiatric evaluation by clinical interviews established the presence/absence of mental (Diagnostic and Statistical Manual-4th edition, Axis I Diagnosis) or spectrum disorders...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29210194/error-related-brain-activity-and-anxiety-symptoms-in-youth-with-autism-spectrum-disorder
#6
Tamara E Rosen, Matthew D Lerner
Individuals with autism spectrum disorder (ASD) often experience symptoms associated with generalized anxiety disorder, obsessive-compulsive disorder, and social anxiety disorder. In other populations, these same symptoms are associated with a larger error-related negativity (ERN), an event-related potential that reflects endogenous threat sensitivity. As such, it is possible that the ERN may relate to the clinical presentation of anxiety in ASD. However, studies examining these associations in youth with ASD have yielded mixed results...
December 6, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29210107/higher-serotonin-transporter-availability-in-early-onset-obsessive-compulsive-disorder-patients-undergoing-escitalopram-treatment-a-11-c-dasb-pet-study
#7
Junhee Lee, Bo-Hyung Kim, Euitae Kim, Oliver D Howes, Kang Ik Kevin Cho, Youngwoo Bryan Yoon, Jun Soo Kwon
OBJECTIVE: Early-onset obsessive-compulsive disorder (EOCD) and late-onset obsessive-compulsive disorder (LOCD) are distinct subtypes of obsessive-compulsive disorder (OCD). OCD patients are treated with serotonin reuptake inhibitors, but the difference in serotonin transporter (SERT) availability between medicated EOCD and LOCD is unexplored yet. METHODS: Six EOCD and 6 LOCD patients were enrolled. They underwent serial [11 C]DASB positron emission tomography scans during maintenance therapy with escitalopram, and their plasma concentration of escitalopram was measured simultaneously with the scan...
December 6, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/29202385/sensory-over-responsivity-in-trichotillomania-hair-pulling-disorder
#8
Martha J Falkenstein, Christine A Conelea, Lauryn E Garner, David A F Haaga
OBJECTIVE: This study was an initial investigation of sensory-over responsivity (SOR) to external sensations among individuals with trichotillomania (TTM). METHODS: Adults endorsing DSM-5 TTM criteria (N = 609) and a non-affected comparison sample (N = 268) completed a self-report survey. RESULTS: The majority of the TTM group endorsed SOR symptoms; three-quarters endorsed at least mild tactile and auditory SOR. About 15% endorsed SOR symptoms in the severe to extreme range...
November 16, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29201116/fluoxetine-regulates-ig-kappa-chain-c-region-expression-levels-in-the-serum-of-obsessive-compulsive-disorder-patients-a-proteomic-approach
#9
Mona Zamanian Azodi, Mostafa Rezaei Tavirani, Afsaneh Arefi Oskouie, Mostafa Hamdieh, Mohammad Kamran Derakhshan, Alireza Ahmadzadeh, Farid Zayeri, Naser Nejadi, Majid Rezaei Tavirani, Vahid Mansouri, Mohammad Rostami-Nejad, Reza Vafaee
Obsessive-Compulsive Disorder (OCD) is one of the most common mental conditions. Proteome profiling may help identifying important proteins and finally shed lights to complexity of OCD underlying mechanisms. Here, by the application gel-based proteomic approach the proteome profile of patients with washing subtype of OCD before and after treatment with Fluoxetine (positive responders) are compared to healthy matched controls. However, only one of the differentially expressed proteins is examined and introduced in this paper...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29200551/efficacy-of-transcranial-direct-current-stimulation-in-the-treatment-resistant-patients-who-suffer-from-severe-obsessive-compulsive-disorder
#10
Kiomars Najafi, Youssef Fakour, Homa Zarrabi, Abtin Heidarzadeh, Mohammadrasoul Khalkhali, Taiebeh Yeganeh, Hasan Farahi, Marziyeh Rostamkhani, Tahereh Najafi, Soheil Shabafroz, Mahdiyeh Pakdaman
Background: During the past years, significant efforts have been made to explain the biological backgrounds of obsessive-compulsive disorder (OCD). Cortical-subcortical and neurotransmitter models are used for explaining the symptoms of OCD, so our hypothesis is that brain's transcranial direct current stimulation (TDCS) can regulate the brain activities of the OCD patients. Thus, based on the mentioned issues, this research seeks to investigate the efficacy of TDCS in treatment-resistant patients who suffer from severe OCD...
September 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29195104/initial-psychometrics-outcomes-and-correlates-of-the-repetitive-body-focused-behavior-scale-examination-in-a-sample-of-youth-with-anxiety-and-or-obsessive-compulsive-disorder
#11
Robert R Selles, Valérie La Buissonnière Ariza, Nicole M McBride, Julie Dammann, Stephen Whiteside, Eric A Storch
BACKGROUND: Body-Focused Repetitive Behaviors (BFRBs), including skin-picking, hair-pulling, and nail-biting, commonly occur in youth, even at elevated/problematic levels, and are associated with a number of other psychiatric symptoms. The present study examined the internal consistency of a brief screening tool for BFRBs as well as the prevalence, severity, and correlates of BFRBs in a sample of youth with a primary anxiety or obsessive-compulsive disorder (OCD). METHODS: Ninety-three youth-parent dyads presenting for treatment for anxiety or OCD completed study measures including the Repetitive Body Focused Behavior Scale - Parent (RBFBS), which includes subscales for skin-picking, hair-pulling, and nail-biting, as well as a number of additional clinician-, parent-, and child-rated scales...
November 7, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29194070/changes-in-gut-microbiota-during-development-of-compulsive-checking-and-locomotor-sensitization-induced-by-chronic-treatment-with-the-dopamine-agonist-quinpirole
#12
Tony D Jung, Paul S Jung, Lucshman Raveendran, Yasamin Farbod, Anna Dvorkin-Gheva, Boris Sakic, Michael G Surette, Henry Szechtman
Long-term treatment of rats with the D2/D3 dopamine agonist quinpirole induces compulsive checking (proposed as animal model of obsessive-compulsive disorder) and locomotor sensitization. The mechanisms by which long-term use of quinpirole produces those behavioral transformations are not known. Here we examined whether changes in gut microbiota play a role in these behavioral phenomena ηP, by monitoring the development of compulsive checking and locomotor sensitization at the same time as measuring the response of gut microbiota to chronic quinpirole injections...
November 29, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29192524/problematic-gaming-behaviour-and-health-related-outcomes-a-systematic-review-and-meta-analysis
#13
Niko Männikkö, Heidi Ruotsalainen, Jouko Miettunen, Halley M Pontes, Maria Kääriäinen
This systematic review and meta-analysis aimed to investigate the interplay between problematic gaming behaviour and health-related outcomes at different developmental stages. A total of 50 empirical studies met the specified inclusion criteria, and a meta-analysis using correlation coefficients was used for the studies that reported adverse health implications regarding the impact of problematic gaming behaviour on depression, anxiety, obsessive-compulsive disorder and somatisation. Overall, the results suggested that problematic gaming behaviour is significantly associated with a wide range of detrimental health-related outcomes...
November 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/29189598/comparison-of-psychiatric-symptoms-in-patients-with-obstructive-sleep-apnea-simple-snoring-and-normal-controls
#14
Jae Myeong Kang, Seong-Jin Cho, Yu Jin Lee, Ji-Eun Kim, Seung-Heon Shin, Kee Hyung Park, Seon Tae Kim, Seung-Gul Kang
OBJECTIVE: Patients with sleep-related breathing disorders are known to have more severe psychiatric symptoms than good sleepers. The aim of this study was to compare the psychiatric symptoms of participants with obstructive sleep apnea (OSA), those with simple snoring (SS), and normal controls (NC). METHODS: A total of 386 participants (260 with OSA, 75 with SS, and 51 NC) completed self-report questionnaires including the Symptoms Checklist 90-Revised (SCL-90-R) and underwent nocturnal polysomnography...
November 17, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/29189409/serotonin-and-love-supporting-evidence-from-a-patient-suffering-from-obsessive-compulsive-disorder
#15
Donatella Marazziti, Stephen M Stahl
No abstract text is available yet for this article.
November 20, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29188734/psychiatric-axis-i-and-personality-axis-ii-disorders-and-subjective-psychiatric-symptoms-in-chronic-tinnitus
#16
Hanna Sahlsten, Tero Taiminen, Max Karukivi, Noora Sjösten, Johanna Nikkilä, Juuso Virtanen, Janika Paavola, Juho Joutsa, Katri Niinivirta-Joutsa, Mari Takala, Anu Holm, Esa Rauhala, Eliisa Löyttyniemi, Reijo Johansson, Satu K Jääskeläinen
OBJECTIVE: Chronic tinnitus has been associated with several psychiatric disorders. Only few studies have investigated these disorders using validated diagnostic interviews. The aims were to diagnose psychiatric and personality disorders with structured interviews, to assess self-rated psychiatric symptoms and elucidate temporal relations between psychiatric disorders and tinnitus. DESIGN: Current and lifetime DSM-IV diagnoses of axis-I (psychiatric disorders) and axis-II (personality disorders) were assessed using structured clinical interviews (SCID-I and -II)...
November 30, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/29186861/mental-health-of-the-prison-medical-workers-pmws-and-influencing-factors-in-jiangxi-china
#17
Xiaojun Liu, Dongdong Jiang, Zhaoxun Hou, Meikun He, Yuanan Lu, Zongfu Mao
Prison medical workers (PMWs) are critically important, but they are also vulnerable to psychological problems. Currently, there is no study on examining PMWs' mental health conditions and possible influencing factors in China. Hence, we conducted this cross-sectional survey, aiming to understand the mental health status of the PMWs and related impact factors in Jiangxi province of China. We employed the Chinese version of the Symptom Checklist-90-R (SCL-90-R) to assess the mental disorders and psychological health conditions of PMWs in Jiangxi...
November 26, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29182616/marble-burying-as-compulsive-behaviors-in-male-and-female-mice
#18
George T Taylor, Sandra Lerch, Sabine Chourbaji
Marble burying is considered an, albeit controversial, animal model of the compulsive like behaviors of obsessive-compulsive disorder (OCD). Hallmark features of OCD patients are similarities and, more prominent, differences from anxiety disorders, e.g., the absence of sex differences and resistance to spontaneous remission. We report an experiment on marble burying by male and female C57/BL6/N mice. Animals were administered either the classic anxiolytic drug, diazepam, that targets the GABA receptor or a "pure" inhibitor of the serotonin transporter, escitalopram, that has been reported to be particularly effective in OCD...
2017: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/29179911/growth-hormone-and-insulin-like-growth-factor-1-secretions-in-eating-disorders-correlations-with-psychopathological-aspects-of-the-disorders
#19
Francesca Brambilla, Paolo Santonastaso, Lorenza Caregaro, Angela Favaro
Hormonal alterations in Eating Disorders (ED) may result from the biochemical stress of malnutrition/starvation. The correlations between some hormonal impairments, particularly of the somatotropic axis, and the psychopathological aspects of ED are still undefined. We measured the plasma concentrations of the somatotropic hormone (GH) and the insulin-like growth factor-1 (IGF-1) in 136 patients with various forms of ED, 65 with restricted Anorexia Nervosa (ANR), 19 with bingeing-purging Anorexia Nervosa (ANBP), 12 with purging-non binging Anorexia Nervosa (ANP), 26 with Bulimia Nervosa (BN), 8 with ED not otherwise specified-anorexic type (EDNOS-AN), 7 with ED not otherwise specified-bulimic type (EDNOS-BN) and in 30 healthy controls...
July 26, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29179725/high-resolution-chromosomal-microarray-analysis-in-paediatric-obsessive-compulsive-disorder
#20
Edna Grünblatt, Beatrice Oneda, Arif B Ekici, Juliane Ball, Julia Geissler, Steffen Uebe, Marcel Romanos, Anita Rauch, Susanne Walitza
BACKGROUND: Obsessive-Compulsive Disorder (OCD) is a common and chronic disorder in which a person has uncontrollable, reoccurring thoughts and behaviours. It is a complex genetic condition and, in case of early onset (EO), the patients manifest a more severe phenotype, and an increased heritability. Large (>500 kb) copy number variations (CNVs) previously associated with autism and schizophrenia have been reported in OCD. Recently, rare CNVs smaller than 500 kb overlapping risk loci for other neurodevelopmental conditions have also been reported in OCD, stressing the importance of examining CNVs of any size range...
November 28, 2017: BMC Medical Genomics
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