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compulsive obsessive disorders

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https://www.readbyqxmd.com/read/29036632/mapping-compulsivity-in-the-dsm-5-obsessive-compulsive-and-related-disorders-cognitive-domains-neural-circuitry-and-treatment
#1
Naomi A Fineberg, Annemieke M Apergis-Schoute, M Matilde Vaghi, Paula Banca, Claire M Gillan, Valerie Voon, Samuel R Chamberlain, Cinosi Eduardo, Reid Jemma, Sonia Shahper, Edward T Bullmore, Barbara J Sahakian, Trevor W Robbins
Compulsions are repetitive, stereotyped thoughts and behaviors designed to reduce harm. Growing evidence suggests that the neurocognitive mechanisms mediating behavioural inhibition (motor inhibition, cognitive inflexibility) reversal learning and habit formation (shift from goal-directed to habitual responding) contribute toward compulsive activity in a broad range of disorders. In obsessive compulsive disorder (OCD), distributed network perturbation appears focussed around the pre-frontal cortex, caudate, putamen and associated neuro-circuitry...
September 23, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29035919/attenuation-of-compulsive-like-behavior-by-fluvoxamine-in-a-non-induced-mouse-model-of-obsessive-compulsive-disorder
#2
Swarup Mitra, Abel Bult-Ito
The current study evaluated the role of strain and compulsive trait differences in response to fluvoxamine, a common obsessive-compulsive disorder (OCD) drug, in two different mouse strains (BIG1 and BIG2) with a spontaneous compulsive-like phenotype. For compulsive-like nest-building behavior, dose-dependent attenuation of nesting by fluvoxamine was observed for the BIG1 compulsive-like strain during the first hour after administration. No significant differences were found for the BIG2 strain during the first hour, although a dose-dependent trend similar to that in the BIG1 strain was observed...
October 13, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29034525/reliability-and-validity-of-severity-dimensions-of-psychopathology-assessed-using-the-structured-clinical-interview-for-dsm-5-scid
#3
Stewart A Shankman, Carter J Funkhouser, Daniel N Klein, Joanne Davila, Debra Lerner, Danelle Hee
This study examined whether the Structured Clinical Interview for DSM (SCID), a widely used semistructured interview designed to assess psychopathology categorically, can be adapted to identify reliable and valid severity dimensions of psychopathology. The present study also examined whether these severity dimensions have better psychometric properties (internal consistency, test-retest reliability, and concurrent and predictive validity) than categorical diagnoses. Participants (N = 234) were recruited from the community and clinics...
October 16, 2017: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/29034243/improving-surgical-outcome-using-diffusion-tensor-imaging-techniques-in-deep-brain-stimulation
#4
REVIEW
Angela An Qi See, Nicolas Kon Kam King
INTRODUCTION: Recent advances in surgical imaging include the use of diffusion tensor imaging (DTI) in deep brain stimulation (DBS) and provide a detailed view of the white matter tracts and their connections which are not seen with conventional magnetic resonance imaging. Given that the efficacy of DBS depends on the precise and accurate targeting of these circuits, better surgical planning using information obtained from DTI may lead to improved surgical outcome. We aim to review the available literature to evaluate the efficacy of such a strategy...
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/29033617/family-accommodation-in-adult-obsessive-compulsive-disorder-clinical-perspectives
#5
REVIEW
Umberto Albert, Alessandra Baffa, Giuseppe Maina
The term accommodation has been used to refer to family responses specifically related to obsessive-compulsive (OC) symptoms: it encompasses behaviors such as directly participating in compulsions, assisting a relative with obsessive-compulsive disorder (OCD) when he/she is performing a ritual, or helping him/her to avoid triggers that may precipitate obsessions and compulsions. At the opposite side, family responses to OCD may also include interfering with the rituals or actively opposing them; stopping accommodating OC symptoms or actively interfering with their performance is usually associated with greater distress and sometimes even with aggressive behaviors from the patients...
2017: Psychology Research and Behavior Management
https://www.readbyqxmd.com/read/29033054/temporary-stages-and-motivational-variables-two-complementary-perspectives-in-the-help-seeking-process-for-mental-disorders
#6
Gema Del Valle Del Valle, Carmen Carrió, Amparo Belloch
INTRODUCTION: Help-seeking for mental disorders is a complex process, which includes different temporary stages, and in which the motivational variables play an especially relevant role. However, there is a lack of instruments to evaluate in depth both the temporary and motivational variables involved in the help-seeking process. This study aims to analyse in detail these two sets of variables, using a specific instrument designed for the purpose, to gain a better understanding of the process of treatment seeking...
October 9, 2017: Revista de Psiquiatrí́a y Salud Mental
https://www.readbyqxmd.com/read/29031568/anxiety-disorders-in-old-age-psychiatric-comorbidities-quality-of-life-and-prevalence-according-to-age-gender-and-country
#7
Alessandra Canuto, Kerstin Weber, Marc Baertschi, Sylke Andreas, Jana Volkert, Maria Christina Dehoust, Susanne Sehner, Anna Suling, Karl Wegscheider, Berta Ausín, Mike J Crawford, Chiara Da Ronch, Luigi Grassi, Yael Hershkovitz, Manuel Muñoz, Alan Quirk, Ora Rotenstein, Ana Belén Santos-Olmo, Arieh Shalev, Jens Strehle, Hans-Ulrich Wittchen, Holger Schulz, Martin Härter
OBJECTIVES: Previous estimates of the prevalence of anxiety disorders in late life vary greatly due to the lack of reliable diagnostic tools. This MentDis_ICF65+ study assessed 12-month prevalence rates of anxiety disorders and age- and gender-related differences in comorbidities, as well as impact on quality of life. DESIGN: The study used a cross-sectional multicenter survey. PARTICIPANTS: The study sample comprised 3,142 men and women aged 65 to 84 years, living in five European countries and Israel...
September 5, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29031217/quality-of-life-and-burden-in-caregivers-of-youth-with-obsessive-compulsive-disorder-presenting-for-intensive-treatment
#8
Monica S Wu, Rebecca Hamblin, Joshua Nadeau, Jessica Simmons, Ashley Smith, Meredith Wilson, Stephanie Eken, Brent Small, Vicky Phares, Eric A Storch
BACKGROUND: Pediatric obsessive-compulsive disorder (OCD) is associated with deleterious familial effects; caregivers are often enmeshed in the disorder and can experience considerable burden and decreased quality of life (QoL). Consequently, this study examined burden and QoL in caregivers of youth with OCD enrolled in an intensive outpatient or partial hospitalization program. METHOD: The relationships between caregiver QoL and burden and the following variables were investigated: OCD symptom severity, functioning (youth functional impairment, general family functioning), family (family accommodation, parental relationship satisfaction, positive aspects of caregiving), and comorbid psychopathology (caregiver anxiety and depressive symptoms, youth internalizing and externalizing behaviors)...
August 30, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29026257/fronto-striatal-glutamate-in-autism-spectrum-disorder-and-obsessive-compulsive-disorder
#9
Jilly Naaijen, Marcel P Zwiers, Houshang Amiri, Steven Cr Williams, Sarah Durston, Bob Oranje, Daniel Brandeis, Regina Boecker-Schlier, Matthias Ruf, Isabella Wolf, Tobias Banaschewski, Jeffrey C Glennon, Barbara Franke, Jan K Buitelaar, David J Lythgoe
This corrects the article DOI: 10.1038/npp.2016.260.
November 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29024649/obsessing-about-uncertainty
#10
Jacqueline Scholl, Matthew F S Rushworth
A striking observation in obsessive-compulsive disorder is that patients know that their obsessions and compulsions are excessive, but their symptoms nevertheless persist. Drawing on computational models from basic neuroscience, Vaghi and colleagues (2017) suggest a quantitative account of this clinical finding.
October 11, 2017: Neuron
https://www.readbyqxmd.com/read/29024130/continuity-between-dsm-5-section-ii-and-section-iii-personality-traits-for-obsessive-compulsive-personality-disorder
#11
Jacqueline Liggett, Martin Sellbom, Bo Bach
OBJECTIVE: Obsessive-compulsive personality disorder (OCPD) is formally operationalized in Section II of the DSM-5 by a heterogeneous collection of 8 categorical criteria. Section III contains an alternative model operationalizing personality disorders via dimensional personality traits and associated impairment. The extent to which the personality traits used to define OCPD in Section III correspond with the Section II operationalization of the disorder is contested. The current study aims to contribute to the evidence base necessary to solidify the optimal trait profile for this disorder via a more fine-tuned examination of OCPD...
October 11, 2017: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/29021824/intense-obsessional-interests-in-children-with-gender-dysphoria-a-cross-validation-study-using-the-teacher-s-report-form
#12
Kenneth J Zucker, A Natisha Nabbijohn, Alanna Santarossa, Hayley Wood, Susan J Bradley, Joanna Matthews, Doug P VanderLaan
OBJECTIVE: This study assessed whether children clinically referred for gender dysphoria (GD) show symptoms that overlap with Autism Spectrum Disorder (ASD). Circumscribed preoccupations/intense interests and repetitive behaviors were considered as overlapping symptoms expressed in both GD and ASD. METHODS: To assess these constructs, we examined Items 9 and 66 on the Teacher's Report Form (TRF), which measure obsessions and compulsions, respectively. RESULTS: For Item 9, gender-referred children (n = 386) were significantly elevated compared to the referred (n = 965) and non-referred children (n = 965) from the TRF standardization sample...
2017: Child and Adolescent Psychiatry and Mental Health
https://www.readbyqxmd.com/read/29020038/correction-integrating-genetic-neuropsychological-and-neuroimaging-data-to-model-early-onset-obsessive-compulsive-disorder-severity
#13
Sergi Mas, Patricia Gassó, Astrid Morer, Anna Calvo, Nuria Bargalló, Amalia Lafuente, Luisa Lázaro
[This corrects the article DOI: 10.1371/journal.pone.0153846.].
2017: PloS One
https://www.readbyqxmd.com/read/29018554/psychiatric-neurosurgery-in-the-21st-century-overview-and-the-growth-of-deep-brain-stimulation
#14
REVIEW
Kenneth Barrett
Ambulatory deep brain stimulation (DBS) became possible in the late 1980s and was initially used to treat people with movement disorders. Trials of DBS in people with treatment-resistant psychiatric disorder began in the late 1990s, initially focusing on obsessive-compulsive disorder, major depressive disorder and Tourette syndrome. Despite methodological issues, including small participant numbers and lack of consensus over brain targets, DBS is now being trialled in a wide range of psychiatric conditions...
October 2017: BJPsych Bulletin
https://www.readbyqxmd.com/read/29017175/body-weight-changes-after-deep-brain-stimulation-for-obsessive-compulsive-disorder-or-depression
#15
Rosalie S N Linssen, Marloes S Oudijn, Mariska Mantione, Pepijn van den Munckhof, Damiaan Denys, P Richard Schuurman
BACKGROUND: In 2010, we published an often-cited case report describing smoking cessation and substantial weight loss after deep brain stimulation (DBS) for obsessive-compulsive disorder (OCD) in an obese patient. To test whether this single observation was also observed in the treated population at large, the weight changes of a larger cohort of patients who underwent DBS for OCD or major depressive disorder (MDD) were studied. RESULTS: Data were available for 46 patients (30 OCD and 16 MDD patients; mean age 46...
October 11, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28992712/-biologic-aspects-of-adhd-and-conduct-disorders-in-childhood-and-adolescence-selected-preventive-aspects
#16
Ivo Paclt, Nikol Přibilová
Next to environmental factors and problems with interpersonal interaction in family represent developmental findings the basic of understanding these disorders (ADHD, conduct disorders, obsessive-compulsive disorders, tic disorders etc.). Knowledges of neurodevelopment disorders represent new possibilities of prevention and treatment.
2017: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/28992533/neural-correlates-of-affective-and-non-affective-cognition-in-obsessive-compulsive-disorder-a-meta-analysis-of-functional-imaging-studies
#17
A Rasgon, W H Lee, E Leibu, A Laird, D Glahn, W Goodman, S Frangou
Obsessive compulsive disorder (OCD) is characterized by intrusive thoughts and repetitive ritualistic behaviors and has been associated with diverse functional brain abnormalities. We sought to synthesize current evidence from functional magnetic resonance imaging (fMRI) studies and examine their alignment to pathogenetic models of OCD. Following systematic review, we identified 54 task-fMRI studies published in the last decade comparing adults with OCD (n=1186) to healthy adults (n=1159) using tasks of affective and non-affective cognition...
September 1, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28990850/the-relationship-between-toxoplasma-gondii-igg-antibodies-and-generalized-anxiety-disorder-and-obsessive-compulsive-disorder-in-children-and-adolescents-a-new-approach
#18
İsmail Akaltun, Soner Sertan Kara, Tayfun Kara
AIM: Toxoplasma gondii may play a role in the development of psychiatric diseases by affecting the brain. The purpose of this study was to examine the relation between serum toxoplasma IgG positivity and obsessive-compulsive disorder (OCD) and generalized anxiety disorder (GAD) in children and adolescents. METHOD: Sixty patients diagnosed with OCD and 60 patients with GAD presenting to the pediatric psychiatry clinic, together with 60 control group subjects with no psychiatric diagnosis, were included in the study...
October 9, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28988149/neural-dysfunction-during-temporal-discounting-in-paediatric-attention-deficit-hyperactivity-disorder-and-obsessive-compulsive-disorder
#19
Luke J Norman, Christina O Carlisi, Anastasia Christakou, Kaylita Chantiluke, Clodagh Murphy, Andrew Simmons, Vincent Giampietro, Michael Brammer, David Mataix-Cols, Katya Rubia
Both Attention-Deficit/Hyperactivity Disorder (ADHD) and Obsessive-Compulsive Disorder (OCD) are associated with choice impulsivity, i.e. the tendency to prefer smaller immediate rewards over larger delayed rewards. However, the extent to which this impulsivity is mediated by shared or distinct underlying neural mechanisms is unclear. Twenty-six boys with ADHD, 20 boys with OCD and 20 matched controls (aged 12-18) completed an fMRI version of an individually adjusted temporal discounting (TD) task which requires choosing between a variable amount of money now or £100 in one week, one month or one year...
November 30, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28982038/drop-out-and-efficacy-of-group-versus-individual-cognitive-behavioural-therapy-what-works-best-for-obsessive-compulsive-disorder-a-systematic-review-and-meta-analysis-of-direct-comparisons
#20
REVIEW
Andrea Pozza, Davide Dèttore
Cognitive behavioural therapy (CBT) is the first-line psychological treatment for Obsessive-Compulsive Disorder (OCD). However, a relevant proportion of individuals with OCD remain untreated or inadequately treated. Group cognitive behavioural therapy (GCBT) may be an alternative treatment modality. Little knowledge is available about the efficacy between GCBT versus individual CBT, particularly on long-term secondary outcomes including anxiety and depression. In addition, drop-out rates have not been investigated by previous meta-analyses...
September 25, 2017: Psychiatry Research
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