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stereotactic ablative radiotherapy

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https://www.readbyqxmd.com/read/29756264/study-design-and-early-result-of-a-phase-i-study-of-sabr-for-early-stage-glottic-cancer
#1
Tosol Yu, Chan Woo Wee, Noorie Choi, Hong-Gyun Wu, Hyun-Cheol Kang, Jong Min Park, Jung-In Kim, Jin Ho Kim, Tack-Kyun Kwon, Eun-Jae Chung
OBJECTIVE: Avoidance of organs at risk has become possible with advances in image-guided volumetric-modulated arc therapy (VMAT) techniques. This study was designed to evaluate the safety and feasibility of stereotactic ablative radiotherapy (SABR) for early stage glottic cancer. This report presents the preliminary result of the first and second dose level. METHODS: Fraction size was increased from 3.5 gray (Gy) (total dose 59.5 Gy) to 9 Gy (total dose 45 Gy). Dose-limiting toxicities were defined as grade 3 or higher treatment-related toxicities...
May 14, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29754789/it-is-not-just-about-surgery-versus-stereotactic-ablative-radiotherapy-it-is-about-curing-as-many-patients-with-lung-cancer-as-possible
#2
EDITORIAL
Alessandro Brunelli
No abstract text is available yet for this article.
April 12, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29753550/rescue-procedure-for-an-electrical-storm-using-robotic-non-invasive-cardiac-radio-ablation
#3
Raphaël Jumeau, Mahmut Ozsahin, Juerg Schwitter, Véronique Vallet, Frédéric Duclos, Michele Zeverino, Raphaël Moeckli, Etienne Pruvot, Jean Bourhis
Stereotactic body radiotherapy (SBRT) is an emerging non-invasive treatment in the management of ventricular tachycardia (VT). We report here an intensive care patient suffering from an electrical storm due to incessant VT, unresponsive to catheter ablation and anti-arrhythmic drugs, showing an immediate and durable response to electrophysiology-guided cardiac SBRT.
May 9, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29752513/oligorecurrent-prostate-cancer-limited-to-lymph-nodes-getting-our-ducks-in-a-row-nodal-oligorecurrent-prostate-cancer
#4
Andrei Fodor, Andrea Lancia, Francesco Ceci, Maria Picchio, Morten Hoyer, Barbara Alicja Jereczek-Fossa, Piet Ost, Paolo Castellucci, Elena Incerti, Nadia Di Muzio, Gianluca Ingrosso
PURPOSE: Oligorecurrent prostate cancer with exclusive nodal involvement represents a common state of disease, amenable to local therapy. New radio-labeled tracers have enriched the possibility of cancer detection and treatment. In this review, we aim to illustrate the main nuclear medicine diagnostic options and the role of radiotherapy in this setting of patients. METHODS: We performed a PubMed search referring to the PRISMA guidelines to analyze the performance of PSMA- and choline-PET in detecting oligorecurrence limited to lymph nodes, and to review the main studies supporting either ablative stereotactic body radiotherapy or regional lymph node irradiation in this clinical setting...
May 11, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29746284/the-concept-of-oligometastases-in-colorectal-cancer-from-the-clinical-evidences-to-new-therapeutic-strategies
#5
Edouard Massaut, Ali Bohlok, Valerio Lucidi, Alain Hendlisz, Jean Klastersky, Vincent Donckier
PURPOSE OF REVIEW: The concept of oligometastases, defining cancers with limited metastatic capacity and attaining a limited number of secondary sites, is now widely accepted, particularly in colorectal cancer. Currently, however, accurate predictive markers for oligometastatic tumors are still lacking. For this reason, it remains challenging to translate this concept into clinical recommendations. In the present work, we review recent publications on oligometastases in colorectal cancer, showing the evidences for such presentation and underlying the need for the identification of biomarkers, necessary to further develop new therapeutic strategies...
May 4, 2018: Current Opinion in Oncology
https://www.readbyqxmd.com/read/29743538/which-technology-to-select-for-primary-focal-treatment-of-prostate-cancer-european-section-of-urotechnology-esut-position-statement
#6
REVIEW
Roman Ganzer, Vinodh Kumar Adithyaa Arthanareeswaran, Hashim U Ahmed, Andrea Cestari, Pascal Rischmann, Georg Salomon, Dogu Teber, Evangelos Liatsikos, Jens-Uwe Stolzenburg, Eric Barret
BACKGROUND: With growing interest in focal therapy (FT) of prostate cancer (PCa) there is an increasing armamentarium of treatment modalities including high-intensity focused ultrasound (HIFU), cryotherapy, focal laser ablation (FLA), irreversible electroporation (IRE), vascular targeted photodynamic therapy (VTP), focal brachytherapy (FBT) and stereotactic ablative radiotherapy (SABR). Currently there are no clear recommendations as to which of these technologies are appropriate for individual patient characteristics...
May 9, 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29735409/comparison-of-survival-and-prognostic-factors-in-patients-treated-with-stereotactic-body-radiotherapy-for-oligometastases-or-oligoprogression
#7
Catherine A Pembroke, Bernard Fortin, Neil Kopek
BACKGROUND AND PURPOSE: Clinical challenges arise in the oligoprogressive (OP) state with little evidence to support the use of ablative strategies. Our aim is to report on outcomes and prognostic variables following stereotactic body radiotherapy (SBRT) for OP and oligometastases (OM). MATERIAL AND METHODS: Overall (OS) and progression-free survivals (PFS) were calculated for 163 patients for 209 lesions (106 OM and 57 OP) treated with SBRT over 9 years. OS and PFS comparisons were calculated using the Kaplan-Meier actuarial survival and log rank methods...
May 4, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29722825/feasibility-of-split-course-stereotactic-ablative-radiotherapy-for-oligometastases
#8
Eun Kyung Paik, Mi-Sook Kim, Young-Seok Seo, Won Jang, Jin-Kyu Kang, Chul-Koo Cho, Hyung Jun Yoo
Background: There is growing interest in the use of stereotactic ablative radiotherapy (SABR) for oligometastases. However, extreme caution should be exercised in treating tumors closely located to organs at risk (OARs) with SABR. To reduce complications, we have applied split-course SABR to oligometastases closely located to OARs or to those being retreated with radiotherapy. Methods: We retrospectively reviewed the records of patients with oligometastases who were treated with planned split-course SABR between January 2012 and December 2016...
May 2, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29708353/-treatment-of-metastatic-renal-cell-carcinoma
#9
Igor Richter, Josef Dvořák
INTRODUCTION: Renal cell cancer accounts for approximately 2-3% of all cases of malignancy. The incidence of kidney cancer in the Czech Republic is the highest in the world. Approximately 70% of renal cell carcinomas are clear-cell renal cancer. Various treatment options for metastatic renal cell cancer (mRCC) have been developed. Treatment regimens comprise antiangiogenic drugs in combination with vascular endothelial growth factor receptor inhibitors, mTOR inhibitors, and immunotherapy...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29698471/dose-gradient-curve-a-new-tool-for-evaluating-dose-gradient
#10
KiHoon Sung, Young Eun Choi
PURPOSE: Stereotactic radiotherapy, which delivers an ablative high radiation dose to a target volume for maximum local tumor control, requires a rapid dose fall-off outside the target volume to prevent extensive damage to nearby normal tissue. Currently, there is no tool to comprehensively evaluate the dose gradient near the target volume. We propose the dose gradient curve (DGC) as a new tool to evaluate the quality of a treatment plan with respect to the dose fall-off characteristics...
2018: PloS One
https://www.readbyqxmd.com/read/29680768/utilization-of-stereotactic-radiosurgery-for-renal-cell-carcinoma-brain-metastases
#11
Waqar Haque, Vivek Verma, E Brian Butler, Bin S Teh
BACKGROUND: Because renal cell carcinoma (RCC) has been traditionally considered a "radioresistant" histology, it may be advantageous to treat brain metastases (BMs) with ablative dosing by means of stereotactic radiosurgery (SRS). This is the first known analysis evaluating utilization of SRS for RCC BMs in the United States. METHODS: The National Cancer Data Base was queried (2005-2014) for metastatic RCC and delivery of intracranial radiotherapy. Patients were stratified into groups receiving either SRS or non-SRS treatment...
April 3, 2018: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29672204/thoracic-intervention-and-surgery-to-cure-lung-an-overview-of-stereotactic-ablative-radiotherapy-in-early-and-oligometastatic-lung-cancer
#12
Bsh Chia, D Landau, G Hanna, J Conibear
No abstract text is available yet for this article.
January 1, 2018: Journal of the Royal Society of Medicine
https://www.readbyqxmd.com/read/29666135/study-protocol-for-the-saron-trial-a-multicentre-randomised-controlled-phase-iii-trial-comparing-the-addition-of-stereotactic-ablative-radiotherapy-and-radical-radiotherapy-with-standard-chemotherapy-alone-for-oligometastatic-non-small-cell-lung-cancer
#13
John Conibear, Brendan Chia, Yenting Ngai, Andrew Tom Bates, Nicholas Counsell, Rushil Patel, David Eaton, Corinne Faivre-Finn, John Fenwick, Martin Forster, Gerard G Hanna, Susan Harden, Philip Mayles, Syed Moinuddin, David Landau
INTRODUCTION: Following growing evidence to support the safety, local control (LC) and potential improvement in overall survival (OS) in patients with oligometastatic non-small cell lung cancer (NSCLC) that have been treated with local ablative therapy such as stereotactic ablative radiotherapy (SABR) and stereotactic radiosurgery (SRS), we initiate the SARON trial to investigate the impact and feasibility of adding SABR/SRS and radical radiotherapy (RRT) following standard chemotherapy on OS...
April 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29650404/stereotactic-ablative-radiotherapy-after-concomitant-chemoradiotherapy-in-non-small-cell-lung-cancer-a-tite-crm-phase-1-trial
#14
Jérôme Doyen, Michel Poudenx, Jocelyn Gal, Josiane Otto, Caroline Guerder, Arash O Naghavi, Anais Gérard, Axel Leysalle, Charlotte Cohen, Bernard Padovani, Antoine Ianessi, Renaud Schiappa, Emmanuel Chamorey, Pierre-Yves Bondiau
BACKGROUND AND PURPOSE: Platinum based chemoradiotherapy is the standard of care for inoperable non-small cell lung cancer (NSCLC). With evidence that NSCLC can have a dose dependent response with stereotactic ablative radiotherapy (SABR), we hypothesize that a SABR boost on residual tumor treated with chemoradiotherapy could increase treatment efficacy. The purpose of this study was to determine feasibility of such an approach. MATERIAL AND METHODS: A prospective phase I trial was performed including 26 patients...
April 9, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29614361/effectiveness-of-pet-ct-as-a-guide-for-palliative-radiation-therapy-for-spinal-metastases
#15
Neil D Almeida, Crystal Adams, Gregory L Davis, Justin Buro, Nadim Nasr, Don McRae, George Cernica, Anthony Caputy, Robert Hong, Jonathan Sherman
BACKGROUND: As back pain is the presenting symptoms in 95% of patients with epidural spinal metastases, appropriately identifying and treating the most symptomatic levels can provide significant palliation. OBJECTIVE: The purpose of this study is to analyze the ability of PET-CT to identify spinal metastases with high metabolic activity and guide radiotherapy. We sought to correlate improvement in back pain with reduction in SUV uptake following treatment. METHODS: We conducted a retrospective review of 72 patients with bony spinal metastases treated with stereotactic ablative radiation therapy at a single center between 2002 and 2014...
March 31, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29608606/lung-density-change-after-sabr-a-comparative-study-between-tri-co-60-magnetic-resonance-guided-system-and-linear-accelerator
#16
Eunji Kim, Hong-Gyun Wu, Jong Min Park, Jung-In Kim, Hak Jae Kim, Hyun-Cheol Kang
Radiation-induced lung damage is an important treatment-related toxicity after lung stereotactic ablative radiotherapy (SABR). After implementing a tri-60Co magnetic-resonance image guided system, ViewRayTM, we compared the associated early radiological lung density changes to those associated with a linear accelerator (LINAC). Eight patients treated with the tri-60Co system were matched 1:1 with patients treated with LINAC. Prescription doses were 52 Gy or 60 Gy in four fractions, and lung dose-volumetric parameters were calculated from each planning system...
2018: PloS One
https://www.readbyqxmd.com/read/29607130/utility-of-stereotactic-ablative-radiotherapy-stereotactic-body-radiation-therapy-in-the-setting-of-oligometastatic-non-small-cell-lung-cancer
#17
EDITORIAL
Andrew Song, Bo Lu
No abstract text is available yet for this article.
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29606150/stereotactic-ablative-radiotherapy-for-ultra-central-lung-tumors-prioritize-target-coverage-or-organs-at-risk
#18
Donna H Murrell, Joanna M Laba, Abigail Erickson, Barbara Millman, David A Palma, Alexander V Louie
BACKGROUND: Lung stereotactic ablative radiotherapy (SABR) is associated with low morbidity, however there is an increased risk of treatment-related toxicity in tumors directly abutting or invading the proximal bronchial tree, termed 'ultra-central' tumors. As there is no consensus regarding the optimal radiotherapy treatment regimen for these tumors, we performed a modeling study to evaluate the trade-offs between predicted toxicity and local control for commonly used high-precision dose-fractionation regimens...
April 2, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29600013/stereotactic-ablative-radiotherapy-for-oligometastatic-non-small-cell-lung-cancer
#19
EDITORIAL
Vivek Verma, Joe Y Chang
No abstract text is available yet for this article.
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29594874/oligometastatic-cancer-in-elderly-patients-the-blitzkrieg-radiotherapy-approach-sbrt-in-oligometastatic-elderly-patients
#20
Andrea Lancia, Gianluca Ingrosso, Alessandra Carosi, Marta Bottero, Alessandro Cancelli, Irene Turturici, Elisabetta Ponti, Riccardo Santoni
AIMS: To retrospectively evaluate the outcome of stereotactic body radiation therapy (SBRT) in the treatment of elderly patients affected by isolated body metastasis from different primitive tumors. METHODS: 70 patients with isolated body metastasis were treated. Median age at diagnosis was 75 years (IQR 69-80). The most common SBRT fractionation scheme was 5 × 7 Gy (total dose 35 Gy). The primary endpoints were Local Control (LC) and Toxicity. Secondary endpoints were Overall Survival (OS) and Disease-Specific Survival (DSS)...
March 29, 2018: Aging Clinical and Experimental Research
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