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stereotactic ablative radiotherapy

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https://www.readbyqxmd.com/read/29333633/long-term-outcome-of-stereotactic-body-radiotherapy-for-patients-with-small-hepatocellular-carcinoma
#1
Katsumaro Kubo, Tomoki Kimura, Hiroshi Aikata, Shigeo Takahashi, Yuki Takeuchi, Ippei Takahashi, Ikuno Nishibuchi, Yuji Murakami, Kazuaki Chayama, Yasushi Nagata
AIM: To evaluate the long-term outcome of stereotactic body radiotherapy in patients with small hepatocellular carcinoma who were ineligible for resection or ablation therapies. METHODS: Sixty-five patients with 74 hepatocellular carcinomas (median tumor size, 16 mm) were enrolled in this study. They were treated with the prescribed dose of 48 Gy in four fractions at the isocenter. We extended the observation period and analyzed long-term outcomes, including overall survival, progression-free survival, local control, and various prognostic factors, in these patients...
January 14, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29328861/radiofrequency-ablation-versus-stereotactic-body-radiotherapy-for-localized-hepatocellular-carcinoma-in-nonsurgically-managed-patients-analysis-of-the-national-cancer-database
#2
Devalkumar J Rajyaguru, Andrew J Borgert, Angela L Smith, Reggie M Thomes, Patrick D Conway, Thorvardur R Halfdanarson, Mark J Truty, A Nicholas Kurup, Ronald S Go
Purpose Data that guide selection of optimal local ablative therapy for the management localized hepatocellular carcinoma (HCC) are lacking. Because there are limited prospective comparative data for these treatment modalities, we aimed to compare the effectiveness of radiofrequency ablation (RFA) versus stereotactic body radiotherapy (SBRT) by using the National Cancer Database. Methods We conducted an observational study to compare the effectiveness of RFA versus SBRT in nonsurgically managed patients with stage I or II HCC...
January 12, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29322682/stereotactic-ablative-radiotherapy-versus-lobectomy-for-stage-i-non-small-cell-lung-cancer-a-systematic-review
#3
Siwei Wang, Xiaoxiao Wang, Qing Zhou, Youtao Xu, Wenjia Xia, Weizhang Xu, ZhiFei Ma, Mantang Qiu, Ran You, Lin Xu, Rong Yin
BACKGROUND: There is debate regarding the use of stereotactic ablative radiotherapy (SABR) or surgery for patients with early stage non-small cell lung cancer (NSCLC). This meta-analysis compared the clinical efficacy of SABR and lobectomy in stage I NSCLC patients. METHODS: An online search identified eight eligible articles (including 2 trials and 7 cohort studies) for inclusion. The odds ratio (OR) was used as a summary statistic. Overall survival (OS), cause-specific survival (CSS), and recurrence-free survival (RFS) were selected to calculate ORs with 95% confidence intervals (CI)...
January 11, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29316943/are-prognostic-indices-for-brain-metastases-of-melanoma-still-valid-in-the-stereotactic-era
#4
Harun Badakhshi, Fidelis Engeling, Volker Budach, Pirus Ghadjar, Sebastian Zschaeck, David Kaul
BACKGROUND: Malignant melanoma brain metastases (MBM) are the third most common cause for brain metastases (BM). Historically Whole-brain radiotherapy (WBRT) was considered the goldstandard of treatment even though melanoma cells are regarded as very radioresistant. Therapeutic possibilities have fundamentally changed since the availability of stereotactic radiotherapy (SRT), where it is possible to apply high ablative doses in a very precise manner. In this work we analyze prognostic factors of overall survival (OS) after SRT in patients with MBM and evaluate the applicability of popular prognostic indices that mainly stem from the WBRT-era...
January 10, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29301352/stereotactic-body-radiation-therapy-in-the-management-of-upper-gi-malignancies
#5
REVIEW
Leila Tchelebi, Nicholas Zaorsky, Heath Mackley
The role of external beam radiation therapy (EBRT) in the management of upper gastrointestinal malignancies is constantly evolving. As radiation therapy techniques improve and are able to deliver more ablative doses of radiotherapy while sparing healthy tissue, radiation can be applied to a wider range of clinical scenarios. Stereotactic body radiation therapy (SBRT) allows a high dose of radiation to be delivered to a highly conformal treatment volume in a short amount of time. Another potential advantage of SBRT is its ability to increase tumor immunogenicity, while also having less of an immunosuppressive effect on the patient, as compared to conventionally fractionated radiation therapy...
January 3, 2018: Biomedicines
https://www.readbyqxmd.com/read/29296040/evaluation-and-performance-of-arccheck-and-film-using-gamma-criteria-in-pre-treatment-quality-assurance-of-stereotactic-ablative-radiotherapy
#6
Prabhakar Ramachandran, Abdulrahman Tajaldeen, David Taylor, Derrick Wanigaratne, Karl Roozen, Moshi Geso
Aim: The aim of this study is to assess the use of ArcCHECK (AC) as an alternative method to replace film dosimetry for pre-treatment quality assurance (QA) of three-dimensional conformal radiation therapy, intensity-modulated radiation therapy (IMRT), and volumetric-modulated arc therapy (VMAT) stereotactic ablative radiotherapy (SABR) treatment plans. Materials and Methods: Twenty-five patients with a varied diagnosis of lung, spine, sacrum, sternum, ribs, scapula, and femur undergoing SABR were selected for this study...
October 2017: Journal of Medical Physics
https://www.readbyqxmd.com/read/29290784/systemic-inflammation-biomarkers-predict-survival-in-patients-of-early-stage-non-small-cell-lung-cancer-treated-with-stereotactic-ablative-radiotherapy-a-single-center-experience
#7
Hui Luo, Hong Ge, Yingying Cui, Jiangong Zhang, Ruitai Fan, Anping Zheng, Xiaoli Zheng, Yanan Sun
Background: Increasing evidence indicates a relationship between systemic inflammation and survival following treatment in various tumors. However, the correlation of systematic inflammation with survival after stereotactic ablative radiotherapy (SABR) in early stage non-small cell lung cancer (NSCLC) has not been well established. Patients and methods: We retrospectively analyzed patients with newly diagnosed early stage NSCLC treated with SABR in a single institution from 2011 to 2015. The neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and lymphocyte- monocyte ratio (LMR) were calculated as systemic inflammation biomarkers...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29277446/phase-i-trial-of-stereotactic-mr-guided-online-adaptive-radiation-therapy-smart-for-the-treatment-of-oligometastatic-or-unresectable-primary-malignancies-of-the-abdomen
#8
Lauren Henke, Rojano Kashani, Clifford Robinson, Austen Curcuru, Todd DeWees, Jeffrey Bradley, Olga Green, Jeff Michalski, Sasa Mutic, Parag Parikh, Jeffrey Olsen
PURPOSE/OBJECTIVES: SBRT is used to treat oligometastatic or unresectable primary abdominal malignancies, although ablative dose delivery is limited by proximity of organs-at-risk (OAR). Stereotactic, magnetic resonance (MR)-guided online-adaptive radiotherapy (SMART) may improve SBRT's therapeutic ratio. This prospective Phase I trial assessed feasibility and potential advantages of SMART to treat abdominal malignancies. MATERIALS/METHODS: Twenty patients with oligometastatic or unresectable primary liver (n = 10) and non-liver (n = 10) abdominal malignancies underwent SMART...
December 22, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29233573/re-irradiation-in-gynaecological-malignancies-a-review
#9
A H Sadozye
Re-irradiation in gynaecological malignancies has become an increasingly frequent consideration. This can be delivered in multiple settings, with the most common being a patient with a history of cervical cancer developing a new vaginal cancer or endometrial cancer with local recurrence after hysterectomy and adjuvant pelvic radiation. A systematic review of the literature has unearthed a handful of reports, most delivering brachytherapy, with a small number on both external beam radiotherapy and stereotactic ablative radiotherapy...
December 9, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29226093/complete-biochemical-response-after-stereotactic-ablative-radiotherapy-of-an-isolated-prostate-cancer-pelvic-soft-tissue-recurrence-detected-by-18f-dcfpyl-pet-ct
#10
Ryan M Phillips, Michael A Gorin, Steven P Rowe, Martin G Pomper, Kenneth J Pienta, Ashley E Ross, Phuoc T Tran
No abstract text is available yet for this article.
January 2018: Urology Case Reports
https://www.readbyqxmd.com/read/29224900/single-fraction-stereotactic-ablative-body-radiotherapy-for-oligometastasis-outcomes-from-132-consecutive-patients
#11
S Gandhidasan, D Ball, T Kron, M Bressel, M Shaw, J Chu, S Chander, G Wheeler, N Plumridge, B Chesson, S David, S Siva
AIMS: Stereotactic ablative body radiotherapy (SABR) is currently used to treat oligometastases, but the optimum dose/fractionation schedule is unknown. In this study, we evaluated outcomes after single fraction SABR in patients with oligometastatic disease. MATERIALS AND METHODS: Single institutional retrospective review of patients treated with single fraction SABR for one to three oligometastases between 2010 and 2015. The primary outcome was freedom from widespread disease defined as distant recurrence not amenable to surgery or SABR; or recurrence with four or more metastases...
December 7, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29205797/stereotactic-ablative-radiotherapy-for-hepatocellular-carcinoma-history-current-status-and-opportunities
#12
REVIEW
Jeffrey Meyer, Amit G Singal
A variety of surgical and other local-regional approaches to the management of hepatocellular carcinoma are in clinical use. External beam radiation therapy is a relative newcomer to the portfolio of treatment options. Advances in planning and delivery of radiation therapy, developing in parallel with and inspiring changing paradigms of tumor management in the field of radiation oncology, have led to growing interest in radiation therapy as a viable treatment option for hepatocellular carcinoma as well as other liver tumors...
December 5, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/29205634/safety-and-feasibility-of-stereotactic-radiotherapy-using-computed-portal-radiography-for-canine-intracranial-tumors
#13
Nicholas J Rancilio, R Timothy Bentley, Jeannie Poulson Plantenga, Magdalena M Parys, Beatriz G Crespo, George E Moore
Stereotactic radiotherapy is a highly conformal treatment option for intracranial and extracranial malignancies. Stereotactic radiotherapy utilizes specialized equipment specifically designed to avoid normal tissue while delivering ablative treatments with submillimeter precision and accuracy. Linear accelerator based stereotactic radiotherapy incorporates on-board image guidance utilizing cone beam computed tomography (CT). Many institutions lack the ability to provide image guidance with cone beam CT but delivery of highly conformal treatments with submillimeter precision and accuracy is still feasible...
December 4, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29196082/feasible-optimization-of-stereotactic-ablative-radiotherapy-dose-by-tumor-size-for-stage-i-non-small-cell-lung-cancer
#14
Sumin Lee, Si Yeol Song, Su Ssan Kim, Wonsik Choi, Hyoung Uk Je, Geum Mun Back, Byungchul Cho, Seong-Yun Jeong, Eun Kyung Choi
INTRODUCTION: The purpose of this study was to assess the effect of dose escalation of stereotactic ablative radiotherapy (SABR) by investigating the long-term clinical outcomes of SABR for stage I non-small-cell lung cancer (NSCLC). METHODS: A retrospective analysis was performed on a total of 169 patients with 178 lesions of stage I NSCLC treated with SABR at a single institution from June 2000 to May 2015. The standard dose scheme for SABR was 48 Gy in 4 fractions during the early period of the analysis, but it was escalated to 60 Gy in 4 fractions from June 2009...
November 14, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29194510/correlation-of-biologically-effective-dose-and-the-tumor-control-in-stage-i-5-cm-non-small-cell-lung-cancer-with-stereotactic-ablative-radiotherapy-a-single-institutional-cohort-study
#15
Wan Jeon, Sung-Ja Ahn, Young-Chul Kim, In-Jae Oh, Chul-Kyu Park, Jae-Uk Jeong, Mee Sun Yoon, Ju-Young Song, Taek-Keun Nam, Woong-Ki Chung
Backgrounds: Stereotactic ablative radiotherapy (SABR) is one of the newly developed innovative radiotherapy and of which optimal dose prescription needs to be standardized. We aimed to investigate the dose-response relationship for patients with SABR. Methods: Fifty-three patients with Stage I non-small cell lung cancer patients, who underwent SABR between November 2006 and January 2015, were evaluated retrospectively. Thirteen patients (24.5%), who refused the surgery were included and 40 patients (75...
November 29, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29191586/outcome-of-radical-local-treatment-of-non-small-cell-lung-cancer-patients-with-synchronous-oligometastases
#16
Margriet Kwint, Iris Walraven, Sjaak Burgers, Koen Hartemink, Houke Klomp, Joost Knegjens, Marcel Verheij, José Belderbos
OBJECTIVES: Patients with stage IV non-small cell lung cancer (NSCLC) are considered incurable and are mainly treated with palliative intent. This patient group has a poor overall survival (OS) and progression free survival (PFS). The purpose of this study was to investigate PFS and OS of NSCLC patients diagnosed with synchronous oligometastatic disease who underwent radical treatment of both intrathoracic disease and metastases. MATERIALS AND METHODS: Patients with NSCLC and oligometastatic disease at diagnosis, who were treated with radical intent between 2008 and 2016, were included in this observational study...
October 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29191470/optimal-beam-margins-in-linac-based-vmat-stereotactic-ablative-body-radiotherapy-a-pareto-front-analysis-for-liver-metastases
#17
Savino Cilla, Anna Ianiro, Francesco Deodato, Gabriella Macchia, Cinzia Digesù, Vincenzo Valentini, Alessio G Morganti
We explored the Pareto fronts mathematical strategy to determine the optimal block margin and prescription isodose for stereotactic body radiotherapy (SBRT) treatments of liver metastases using the volumetric-modulated arc therapy (VMAT) technique. Three targets (planning target volumes [PTVs] = 20, 55, and 101 cc) were selected. A single fraction dose of 26 Gy was prescribed (prescription dose [PD]). VMAT plans were generated for 3 different beam energies. Pareto fronts based on (1) different multileaf collimator (MLC) block margin around PTV and (2) different prescription isodose lines (IDL) were produced...
November 27, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29189331/ablative-radiotherapy-doses-for-locally-advanced-pancreatic-cancer-lapc
#18
Christopher H Crane, Eileen M O'Reilly
Standard palliative doses of radiation for locally advanced unresectable pancreatic cancer have had minimal to no impact on survival. Randomized trials evaluating these palliative doses have not shown a significant survival benefit with the use of radiation as consolidation after chemotherapy. Results from nonrandomized studies of 3- to 5-fraction low-dose stereotactic radiation (SBRT) have likewise had a minimal impact, but with less toxicity and a shorter treatment time. Doses of SBRT have been reduced to half the level that is necessary (biological equivalent dose, BED of 53 Gy) to achieve tumor ablation in the treatment of other solid tumors (100 Gy BED) to protect the gastrointestinal (GI) tract...
November 2017: Cancer Journal
https://www.readbyqxmd.com/read/29162055/stereotactic-body-radiotherapy-sbrt-for-locally-advanced-intrahepatic-and-extrahepatic-cholangiocarcinoma
#19
Eleni Gkika, Lukas Hallauer, Simon Kirste, Sonja Adebahr, Nico Bartl, Hannes Philipp Neeff, Ralph Fritsch, Volker Brass, Ursula Nestle, Anca Ligia Grosu, Thomas Baptist Brunner
BACKGROUND: To evaluate the role of ablative radiotherapy doses in the treatment of hilar or intrahepatic cholangiocarcinoma (CCC) using stereotactic body radiotherapy (SBRT). METHODS: Consecutive patients treated from 2007 to 2016 with CCC were evaluated. Local control and toxicities were assessed every 3 months according to the Response Evaluation Criteria In Solid Tumors (RECIST) and the Common Terminology Criteria for Adverse Events v4.0, respectively. Overall survival (OS), local control (LC) and progression free survival were calculated from SBRT...
November 21, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29155507/the-role-of-radiation-therapy-in-the-modern-management-of-oligometastatic-disease
#20
Yan Li, Suyu Tao, Mengru Li, Duojie Li
Multimodal treatment approaches are indispensable for patients with advanced-stage cancer, while radiation therapy has been established as essential part of therapeutic approaches and has been introduced as a better option to face challenges, such as, local relapse or oligometastatic disease. The mere insight of the concept of oligometastases, proposed for the first time in the middle 1990s, led to the hypothesis that this condition may be cured using local ablative weapons. This hypothesis has already been demonstrated by surgical ablative techniques...
July 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
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