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stereotactic ablative radiotherapy

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https://www.readbyqxmd.com/read/29155507/the-role-of-radiation-therapy-in-the-modern-management-of-oligometastatic-disease
#1
Yan Li, Suyu Tao, Mengru Li, Duojie Li
Multimodal treatment approaches are indispensable for patients with advanced-stage cancer, while radiation therapy has been established as essential part of therapeutic approaches and has been introduced as a better option to face challenges, such as, local relapse or oligometastatic disease. The mere insight of the concept of oligometastases, proposed for the first time in the middle 1990s, led to the hypothesis that this condition may be cured using local ablative weapons. This hypothesis has already been demonstrated by surgical ablative techniques...
July 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29132801/robotic-stereotactic-treatment-for-malignant-metastasis-of-solid-tumour-in-the-pancreas-a-multiple-case-report-and-review-of-literature
#2
M Loi, A Magallon-Baro, C Papalazarou, M Milder, J J Nuyttens
Metastatic involvement of the pancreas occurs in 5% of patients affected by advanced malignancies. Surgical resection has been reported by number of authors as a valuable option to improve disease control, in particular in patients with limited disease burden and favourable histotypes; however, the benefit of this procedure has been questioned due to patient selection, technical challenges and relevant risk of perioperative mortality and severe complications. In the present study, a cohort of surgically unfit patients affected by a solitary metastasis in the pancreas from various primary tumours received stereotactic radiotherapy with an ablative dose schedule, obtaining promising local and distant disease progression-free delay with minor toxicity...
November 10, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29100293/gamma-analysis-with-a-gamma-criterion-of-2-1-mm-for-stereotactic-ablative-radiotherapy-delivered-with-volumetric-modulated-arc-therapy-technique-a-single-institution-experience
#3
Jung-In Kim, Minsoo Chun, Hong-Gyun Wu, Eui Kyu Chie, Hak Jae Kim, Jin Ho Kim, Jong Min Park
To report a single-institution experience of gamma evaluations with 2%/1 mm for stereotactic ablative radiotherapy (SABR) delivered with volumetric modulated arc therapy (VMAT) technique, from January 2014 to January 2016. A total of 168 SABR VMAT plans were analyzed with a gamma criterion of 2%/1 mm, a threshold value of 10%, and a tolerance level of 90%. Of the 168 cases, four cases failed with 2%/1 mm. The average passing rate was 97.0% ± 2.5%. Three of the four failed cases showed passing rates higher than 90%, which was achieved by shifting the measuring device by 1 mm in the left-to-right or anterior-to-posterior directions...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29081843/clinical-staging-of-nsclc-current-evidence-and-implications-for-adjuvant-chemotherapy
#4
REVIEW
David J Heineman, Johannes M Daniels, Wilhelmina H Schreurs
Survival of all non-small cell lung cancer (NSCLC) patients is disappointing, with a 5-year survival of 18%. Staging NSCLC patients is crucial because it determines the choice of treatment and prognosis. Clinical staging is a complex process that comes with many challenges and with low accuracy between the clinical and pathological stage. Treatment modalities for stage I-III NSCLC consist of surgical resection, radiotherapy and chemotherapy. This review describes the current evidence on staging and the implications on adjuvant chemotherapy...
September 2017: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/29070582/lung-segmentectomy-does-it-offer-a-real-functional-benefit-over-lobectomy
#5
REVIEW
Anne Charloux, Elisabeth Quoix
Anatomical segmentectomy has been developed to offer better pulmonary function preservation than lobectomy, in stage IA lung cancer. Despite the retrospective nature of most of the studies and the lack of randomised studies, a substantial body of literature today allows us to evaluate to what extent lung function decreases after segmentectomy and whether segmentectomy offers a real functional benefit over lobectomy. From the available series, it emerges that the mean decrease in forced expiratory volume in 1 s (FEV1) is low, ranging from -9% to -24% of the initial value within 2 months and -3 to -13% 12 months after segmentectomy...
December 31, 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29069831/stereotactic-ablative-body-radiotherapy-for-spinal-metastasis-from-hepatocellular-carcinoma-its-oncologic-outcomes-and-risk-of-vertebral-compression-fracture
#6
Gyu Sang Yoo, Hee Chul Park, Jeong Il Yu, Do Hoon Lim, Won Kyung Cho, Eonju Lee, Sang Hoon Jung, Youngyih Han, Eun-Sang Kim, Sun-Ho Lee, Whan Eoh, Se-Jun Park, Sung-Soo Chung, Chong-Suh Lee, Joon Hyuk Lee
Spinal metastases from hepatocellular carcinoma (HCC) require high-dose irradiation for durable pain and tumor control. Stereotactic ablative body radiotherapy (SABR) enables the delivery of high-dose radiation. However, but vertebral compression fracture (VCF) can be problematic. The aim of his study is to evaluate the outcome and risk of VCF after SABR for spinal metastasis from HCC. We retrospectively reviewed 33 lesions in 42 spinal segments from 29 patients who received SABR with 1 fraction (16-20 Gy), or 3 fractions (18-45 Gy) from September 2009 to January 2015...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29066125/pelvic-re-irradiation-using-stereotactic-ablative-radiotherapy-sabr-a-systematic-review
#7
REVIEW
Louise Janet Murray, John Lilley, Maria A Hawkins, Ann M Henry, Peter Dickinson, David Sebag-Montefiore
BACKGROUND AND PURPOSE: To perform a systematic review regarding the use of stereotactic ablative radiotherapy (SABR) for the re-irradiation of recurrent malignant disease within the pelvis, to guide the clinical implementation of this technique. MATERIAL AND METHODS: A systematic search strategy was adopted using the MEDLINE, EMBASE and Cochrane Library databases. RESULTS: 195 articles were identified, of which 17 were appropriate for inclusion...
October 21, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29037776/a-multicentre-end-to-end-dosimetry-audit-of-motion-management-4dct-defined-motion-envelope-in-radiotherapy
#8
Antony L Palmer, David Nash, John R Kearton, Shakardokht M Jafari, Sarah Muscat
PURPOSE: External dosimetry audit is valuable for the assurance of radiotherapy quality. However, motion management has not been rigorously audited, despite its complexity and importance for accuracy. We describe the first end-to-end dosimetry audit for non-SABR (stereotactic ablative body radiotherapy) lung treatments, measuring dose accumulation in a moving target, and assessing adequacy of target dose coverage. MATERIALS AND METHODS: A respiratory motion lung-phantom with custom-designed insert was used...
October 13, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29033164/uk-consensus-on-normal-tissue-dose-constraints-for-stereotactic-radiotherapy
#9
G G Hanna, L Murray, R Patel, S Jain, K L Aitken, K N Franks, N van As, A Tree, P Hatfield, S Harrow, F McDonald, M Ahmed, F H Saran, G J Webster, V Khoo, D Landau, D J Eaton, M A Hawkins
Six UK studies investigating stereotactic ablative radiotherapy (SABR) are currently open. Many of these involve the treatment of oligometastatic disease at different locations in the body. Members of all the trial management groups collaborated to generate a consensus document on appropriate organ at risk dose constraints. Values from existing but older reviews were updated using data from current studies. It is hoped that this unified approach will facilitate standardised implementation of SABR across the UK and will allow meaningful toxicity comparisons between SABR studies and internationally...
October 12, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29019420/what-role-does-stereotactic-ablative-radiotherapy-have-in-advanced-castrate-resistant-prostate-cancer
#10
Ryan Phillips, Piet Ost, Phuoc T Tran
No abstract text is available yet for this article.
October 11, 2017: Future Oncology
https://www.readbyqxmd.com/read/28993019/a-modified-formula-for-dose-calculations-of-stereotactic-ablative-body-radiotherapy-for-non-small-cell-lung-cancer
#11
Yangsen Cao, Xiaofei Zhu, Yu Zhang, Chunshan Yu, Yongming Liu, Yongjian Sun, Zhitao Dai, Xueling Guo, Xiaoping Ju, Huojun Zhang
To provide a modified formula consistent with the Monte Carlo (MC) algorithm for dose calculations during stereotactic ablative body radiotherapy for non-small cell lung cancer. Seventy CyberKnife treatment plans were calculated and analyzed by MC and ray-tracing (RT) algorithms, separately. Parameters of treatment plans were compared, and those associated with differences of dose distributions were analyzed to establish a modified formula. Gross tumor volume and tumor tracking volume (TTV) were defined as the evident disease on the sequences of the window width and level of the lung and the mediastinum...
October 6, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28975081/radiotherapy-for-oligometastatic-lung-cancer
#12
REVIEW
Derek P Bergsma, Joseph K Salama, Deepinder P Singh, Steven J Chmura, Michael T Milano
Non-small cell lung cancer (NSCLC) typically presents at an advanced stage, which is often felt to be incurable, and such patients are usually treated with a palliative approach. Accumulating retrospective and prospective clinical evidence, including a recently completed randomized trial, support the existence of an oligometastatic disease state wherein select individuals with advanced NSCLC may experience historically unprecedented prolonged survival with aggressive local treatments, consisting of radiotherapy and/or surgery, to limited sites of metastatic disease...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28973074/consolidative-radiotherapy-for-limited-metastatic-non-small-cell-lung-cancer-a-phase-2-randomized-clinical-trial
#13
Puneeth Iyengar, Zabi Wardak, David E Gerber, Vasu Tumati, Chul Ahn, Randall S Hughes, Jonathan E Dowell, Naga Cheedella, Lucien Nedzi, Kenneth D Westover, Suprabha Pulipparacharuvil, Hak Choy, Robert D Timmerman
Importance: Patterns-of-failure studies suggest that in metastatic non-small-cell lung cancer (NSCLC) sites of gross disease at presentation are the first to progress when treated with chemotherapy. This knowledge has led to increased adoption of local ablative radiation therapy in patients with stage IV NSCLC, though prospective randomized evidence is limited. Objective: To determine if intervening with noninvasive stereotactic ablative radiotherapy (SAbR) prior to maintenance chemotherapy in patients with non-progressive limited metastatic NSCLC after induction therapy led to significant improvements in progression-free survival (PFS)...
September 24, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28972833/management-of-patients-with-stage-i-lung-cancer
#14
Jeffrey A Bogart, Jason Wallen
The treatment of stage I non-small-cell lung cancer has advanced markedly over the past century. The transition from therapeutic nihilism with ensured mortality to radical surgery with pneumonectomy to rational oncologic-based resection has resulted in dramatically improved outcomes and reduced morbidity. The superiority of anatomic resection with lobectomy over sublobar resection for fit patients with stage I disease, where more than one half of all patients should expect to be cured, is backed by level 1 evidence...
February 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28958106/-stereotactic-body-radiotherapy-for-early-stage-nsclc-what-is-the-evidence
#15
Matthias Guckenberger
Stereotactic body radiotherapy (SBRT) was first described in the mid 90s as a technique using high precision radiotherapy to deliver escalated, ablative irradiation doses and which simultaneously minimised incidental irradiation of healthy tissue. Technological and clinical development of this technique has been pioneered in the field of early stage non-small cell lung cancer, where improved local tumor control led to prolonged overall survival. Today, SBRT is the evidence-based and guideline-recommended treatment of choice for early stage NSCLC in patients who are medically inoperable...
September 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/28932579/patient-reported-outcomes-following-video-assisted-thoracoscopic-vats-resection-or-stereotactic-ablative-body-radiotherapy-sabr-for-treatment-of-non-small-cell-lung-cancer-protocol-for-an-observational-pilot-study-lilac
#16
Cecilia Pompili, Kevin N Franks, Alessandro Brunelli, Yusuf S Hussain, Patricia Holch, Matthew E Callister, Jonathan M Robson, Kostas Papagiannopoulos, Galina Velikova
BACKGROUND: Lung cancer is increasingly a disease of the elderly and frail population with a median age of 70 years at diagnosis. Therefore, consideration of the impact of interventions on health-related quality of life (HRQOL) and not only absolute survival is especially important. For non-small cell lung cancer (NSCLC), video-assisted thoracoscopic surgery (VATS) has been gaining popularity over the last few decades, replacing traditional open lobectomies. For high-risk patients who are not deemed suitable for surgery, stereotactic ablative body radiotherapy (SABR) provides a potentially curative alternative...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28932513/role-of-consolidative-stereotactic-ablative-radiotherapy-in-patients-with-oligometastatic-non-small-cell-lung-cancer
#17
EDITORIAL
Umberto Ricardi, Niccolò Giaj Levra, Serena Badellino, Filippo Alongi
No abstract text is available yet for this article.
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28918804/recent-advances-in-therapeutic-endosonography-for-cancer-treatment
#18
REVIEW
Saurabh Mukewar, Venkataraman Raman Muthusamy
Therapeutic endosonography (EUS) may play an important role in the management of cancers. EUS-guided fiducial placement has a high success rate and can aid in stereotactic radiotherapy. EUS-guided tumor ablation therapies can help in palliation of locally advanced tumors. EUS-guided antitumor injection seems to be feasible and safe in animals; initial human studies suffer from small sample size and lack of controls. Randomized, controlled trials have not shown benefit over conventional therapy. EUS celiac plexus neurolysis has gained popularity and is performed by interventional endosonographers...
October 2017: Gastrointestinal Endoscopy Clinics of North America
https://www.readbyqxmd.com/read/28917256/postoperative-stereotactic-body-radiotherapy-for-spinal-metastases
#19
Majed Alghamdi, Chia-Lin Tseng, Sten Myrehaug, Pejman Maralani, Chris Heyn, Hany Soliman, Young Lee, Mark Ruschin, Leodante Da Costa, Victor Yang, Mikki Campbell, Arjun Sahgal
Spine is a common site of metastases in cancer patients. Spine surgery is indicated for select patients, typically those with mechanical instability and/or malignant epidural spinal cord (or cauda equina) compression. Although post-operative conventional palliative external beam radiation therapy has been the standard of care, technical improvements in radiation planning and image-guided radiotherapy have allowed for the application of stereotactic body radiotherapy (SBRT) to the spine. Spine SBRT is intended to ablate residual tumor and optimize local control by delivering several fold greater biologically effective doses...
September 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28917255/stereotactic-body-radiotherapy-for-primary-renal-cell-carcinoma-and-adrenal-metastases
#20
Gargi Kothari, Alexander V Louie, David Pryor, Ian Vela, Simon S Lo, Bin S Teh, Shankar Siva
The incidence of renal cell carcinoma (RCC) and metastatic adrenal lesions continues to rise and present evolving complexities in terms of management. Technical challenges in treatment delivery are compounded by the setting of an ageing patient population with multiple medical co-morbidities. While the standard of care treatment for both primary RCC and oligometastatic adrenal lesions has typically been surgery, a number of patients may be medically or surgically inoperable, and for whom alternative options require consideration...
September 2017: Chinese Clinical Oncology
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