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Peter C Oakes, Christian Fisahn, Joe Iwanaga, Daniel DiLorenzo, Rod J Oskouian, R Shane Tubbs
INTRODUCTION: The development of our current understanding of the autonomic nervous system has a rich history with many international contributors. CONCLUSIONS: Although our thoughts of an autonomic nervous system arose with the Greeks, the evolution and final understanding of this neural network would not be fully realized until centuries later. Therefore, our current knowledge of this system is based on hundreds of years of hypotheses and testing and was contributed to by many historic figures...
September 9, 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Hwan Jun Choi, Jun Beom Lee
Dentigerous cyst (DC), also known as follicular cyst, is an odontogenic cyst with fluid accumulation between the crown and enamel organ of an unerupted tooth, pushing the crown away from the alveolar bone. The patients with DC in the maxillary sinus should be evaluated thoroughly by extraoral and intraoral examinations, proper diagnostic imaging procedures, and pathologic examination to avoid misdiagnosis of maxillary sinusitis. The standard treatment for DC in the maxillary sinus is often removed by Caldwell-Luc approach...
July 2016: Journal of Craniofacial Surgery
Zoe M Adams, Joseph J Fins
The persistent vegetative state (PVS) is one of the most iconic and misunderstood phrases in clinical neuroscience. Coined as a diagnostic category by Scottish neurosurgeon Bryan Jennett and American neurologist Fred Plum in 1972, the phrase "vegetative" first appeared in Aristotle's treatise On the Soul (circa mid-fourth century BCE). Aristotle influenced neuroscientists of the nineteenth and early-twentieth centuries, Xavier Bichat and Walter Timme, and informed their conceptions of the vegetative nervous system...
June 13, 2016: Journal of the History of the Neurosciences
Florina Popa, Oana Rosca, Alexandru Georgescu, Claudio Cannistra
BACKGROUND AND AIMS: The clinical results of the vertical "vest-over-pants" Mayo repair were evaluated, and the risk factors for incisional hernia recurrence were studied. The purpose of this study is to point out the importance of reducing pre and post operative risk factors in the incisional hernia repair process in order to achieve a physiologically normal abdominal wall. METHODS: Twenty patients diagnosed with incisional hernia underwent an abdominal reconstruction procedure using the Mayo (Paletot) technique at Bichat Claude Bernard Hospital between 2005 and 2015...
2016: Clujul Medical (1957)
Bengt Erik Haug, Ketil André Camilio, Liv Tone Eliassen, Wenche Stensen, John Sigurd Svendsen, Kristel Berg, Bjarte Mortensen, Guillaume Serin, Jean-Francois Mirjolet, Francis Bichat, Øystein Rekdal
Oncolytic immunotherapies represent a new promising strategy in the treatment of cancer. In our efforts to develop oncolytic peptides, we identified a series of chemically modified 9-mer cationic peptides that were highly effective against both drug-resistant and drug-sensitive cancer cells and with lower toxicity toward normal cells. Among these peptides, LTX-315 displayed superior anticancer activity and was selected as a lead candidate. This peptide showed relative high plasma protein binding abilities and a human plasma half-life of 160 min, resulting in formation of nontoxic metabolites...
April 14, 2016: Journal of Medicinal Chemistry
A Kulyapina, J Verdaguer Martin, C Navarro Cuellar, C Navarro Vila
Osteopetrosis (OP) is a rare metabolic bone disease characterized by a generalized increase in skeletal mass. The disease is characterized by increased susceptibility to develop osteomyelitis of the jaws. We report a case of clinical and radiological progression of bimaxillary osteomyelitis in a patient with autosomal dominant OP. The patient presented non simultaneous osteomyelitis in both upper and lower jaws with time interval of 10 years. The osteomyelitis of maxilla resulted in oroantral fistula formation and required surgical closure with Bichat fat pad flap...
March 2016: Journal of Maxillofacial and Oral Surgery
F Chaucheyras-Durand, A Ameilbonne, A Bichat, P Mosoni, F Ossa, E Forano
AIMS: To monitor the effect of a live yeast additive on feedstuff colonization by targeted fibrolytic micro-organisms and fibre degradation in the cow rumen. METHODS AND RESULTS: Abundance of adhering fibrolytic bacteria and fungi on feedstuffs incubated in sacco in the cow rumen was quantified by qPCR and neutral detergent fibre (NDF) degradation was measured. Saccharomyces cerevisiae I-1077 (SC) increased the abundance of fibre-associated Fibrobacter succinogenes on wheat bran (WB) and that of Ruminococcus flavefaciens on alfalfa hay (AH) and wheat silage (WS)...
March 2016: Journal of Applied Microbiology
Gianluca Porcaro, Ernesto Amosso, Luca Mirabelli, Alberto Busa, Fabrizio Carini, Marcello Maddalone
Osteoradionecrosis (ORN) of the jaw is a complication of radiation therapy for head and neck cancers. We report a case of ORN of the posterior maxilla treated with Er: YAG laser and a pedicled buccal fat pad (bichat bulla adipose) flap. A 69-year-old man presented complaining of pain on left maxilla. He had received high-dose radiotherapy (90 Gy) for squamous cell carcinoma of the left soft palate 2 years earlier. Clinical and radiographic examinations revealed ORN of the left maxillary molar region and maxillary sinusitis...
October 2015: Journal of Craniofacial Surgery
Rocío Alonso-González, María Peñarrocha-Diago, David Peñarrocha-Oltra, Amparo Aloy-Prósper, Fabio Camacho-Alonso, Miguel Peñarrocha-Diago
PURPOSE: To report the closure of oroantral communications with the pedicled buccal fat pad in a series of patients, and to determine the level of patient satisfaction after the surgery. STUDY DESIGN: A prospective study of patients diagnosed of unilateral or bilateral oroantral communication (OAC) closed using the buccal fat pad between May 2012 and January 2013 was performed. Data analysis extended to: age, sex, and cause, location and size of oroantral communication...
February 2015: Journal of Clinical and Experimental Dentistry
David Peñarrocha-Oltra, Rocio Alonso-González, Hilario Pellicer-Chover, Amparo Aloy-Prósper, María Peñarrocha-Diago
The aim of this study was to assess the use of buccal fat pad (BFP) technique as an option to close oroantral communications (OAC) after removing failed zygomatic implants in a patient with a severely resorbed maxilla, and to determine the degree of patient satisfaction. A 64-year-old woman presented recurrent sinusitis and permanent oroantral communication caused by bilateral failed zygomatic implants, 3 years after prosthetic loading. Zygomatic implants were removed previous antibiotic treatment and the BFP flap technique was used to treat the OAC and maxillary defect...
February 2015: Journal of Clinical and Experimental Dentistry
Maria Chauchard, Khadija Benali, Thomas Papo, Karim Sacre
Venous thromboembolism (VTE) can be the first clinical manifestation of an occult malignancy. We aimed to assess the value, in daily practice, of positron emission tomography combined with computed tomography (PET-CT) for occult malignancy diagnosis in patients with unprovoked VTE.All PET-CTs performed over 5-years period (from January 2009 to October 2013) in adult patients followed in the Department of Internal Medicine (Bichat Hospital, Paris, France) were retrospectively reviewed. Clinical history, imaging findings, and additional diagnostic tests performed because of PET-CT findings were analyzed...
November 2014: Medicine (Baltimore)
J-P Lanoix, S Gaudry, R Flicoteaux, R Ruimy, M Wolff
BACKGROUND: Although tuberculosis (TB) is not a major public health issue in low-burden countries, severe cases are still a matter of concern. OBJECTIVE: To assess the risk factors for mortality due to TB in a low-burden setting. DESIGN: A retrospective study of 97 patients hospitalised with active TB in the intensive care unit (ICU) of the Bichat-Claude Bernard Hospital, Paris, France, from 2000 to 2009. RESULTS: The mean age was 47...
May 2014: International Journal of Tuberculosis and Lung Disease
C Fernandez, V Gazaille, A Werbrouck-Chiraux, O Belmonte, N Sultan-Bichat, P Agape, F Chretien, P Schlossmacher
INTRODUCTION: Histoplasmosis is a fungal infection caused by Histoplasma capsulatum var. capsulatum. It shows pulmonary or multivisceral involvement. Infective spores are inhaled from soils that contain bat or bird guano. The clinical picture depends on the intensity of the exposure and the immune status of the host. CASE REPORTS: We report two cases of histoplasmosis that reflect its variability in clinical and histopathological expression: a pseudo-tumoral nodular form or histoplasmoma in a pauci-symptomatic immunocompetent patient and a disseminated form with severe respiratory and mucocutaneous involvement in an immunocompromised patient...
May 2014: Revue des Maladies Respiratoires
Emanuela Romano, Olivier Michielin, Verena Voelter, Julien Laurent, Hélène Bichat, Athina Stravodimou, Pedro Romero, Daniel E Speiser, Frédéric Triebel, Serge Leyvraz, Alexandre Harari
BACKGROUND: Immunotherapy offers a promising novel approach for the treatment of cancer and both adoptive T-cell transfer and immune modulation lead to regression of advanced melanoma. However, the potential synergy between these two strategies remains unclear. METHODS: We investigated in 12 patients with advanced stage IV melanoma the effect of multiple MART-1 analog peptide vaccinations with (n = 6) or without (n = 6) IMP321 (LAG-3Ig fusion protein) as an adjuvant in combination with lymphodepleting chemotherapy and adoptive transfer of autologous PBMCs at day (D) 0 (Trial registration No: NCT00324623)...
2014: Journal of Translational Medicine
Golriz Pahlavan, Charles Burdet, Cédric Laouénan, Frédérique Guiroy, Fabrice Bouscarat, William Tosini, Yazdan Yazdanpanah, Elisabeth Bouvet
Bichat Hospital's free and anonymous Voluntary Counseling and Testing centre in Paris is widely visited, with a high rate of HIV-positive diagnosis. This study proposed, in this centre, to describe the HIV newly-diagnosed patients over an 8-year period and to determinate risk factors for failure to return for a positive result. Higher risk for failure to return was found among the heterosexual subjects regardless of their socio-economic background.
January 2015: International Journal of STD & AIDS
D Schäfer
For very long medicine has been dealing with the question what death means and when it has occurred. The promotion of this debate is mainly owed to the new medical findings and the concrete requirements of the clinical practice; but other factors like social-historical influences (in particular the dispute over the secure determination of death) as well as the (de-)medicalization of the concept of death have also to be taken into account. In a concise historical overlook this study aims to demonstrate the development of the definition of death: In ancient Greece Aristotle, disregarding the transcendent teleology, describes the natural or non-natural death that occurs when the production of the vegetative warmth in the central organ - the heart - has ceased...
December 2013: Deutsche Medizinische Wochenschrift
F Marc, C Esquirol, E Papy, P Longuet, L Armand-Lefevre, C Rioux, S Diamantis, C Dumortier, N Bourgeois-Nicolaos, J-C Lucet, M Wolff, P Arnaud
OBJECTIVE: We retrospectively studied daptomycin use during 2010 at the Bichat-Claude-Bernard teaching-hospital (Paris) to observe the evolution of daptomycin prescriptions. PATIENTS AND METHODS: Twenty-one patients were included and several parameters were documented: site of infection, bacterial species involved, reason for daptomycin use, dose and clinical outcome. RESULTS: Ninety-five percent of daptomycin prescritions were off-label and most did not comply with local guidelines...
January 2014: Médecine et Maladies Infectieuses
Elie Kantor, Philippe Montravers, Dan Longrois, Jean Guglielminotti
BACKGROUND: Patients assess their own pain with a numerical rating scale (NRS). In the postanaesthesia care unit (PACU), NRS helps to determine and monitor analgesic administration, but is useless in patients who are unable to communicate. In non-PACU patients, acute pain increases pupillary diameter and pupillary light reflex amplitude (PLRA), the difference between pupillary diameter before and after light stimulation. OBJECTIVES: To study the association between postoperative pain (NRS) and pupillary diameter or PLRA in PACU patients after routine anaesthetic care...
February 2014: European Journal of Anaesthesiology
Amancio Fernández, Alvaro Fernández-Alcalde, Celia Fernández-Alcalde
OBJECTIVES: We performed a study on the notes made by doctor Antonio Alfaro to the book by Bichat and Desault "Treaty of urinary tract diseases". RESULTS: Such notes are altogether more extensive than the work they accompany. In them we see the knowledge about the treatment of urinary tract diseases in the beginning of the XIX century had a great level and, at least, similar to that of other European countries. The notes are accompanied by multiple references to surgeons of various times, and publications of that time...
October 2013: Archivos Españoles de Urología
Annaë Liu, Mélisande Bernard
BACKGROUND: Based on solid experience in renal transplant, new treatments aiming to decrease anti-human leukocyte antigen (HLA) antibodies in patients awaiting lung transplant have recently been developed. The off-label use of high-dose intravenous polyvalent immunoglobulins (IVIg) and/or plasmapheresis changes the economical weight of pharmaceutical cost before lung transplantation. OBJECTIVE: Our objective was to assess the budgetary impact of pharmaceutical costs of desensitization therapy...
February 2014: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
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