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REVIEW
Bryan Schreiner, Robert Unger, Andrea S Herzka, Darin M Friess, Omar F Nazir, Jacqueline M Brady
INTRODUCTION: American Board of Orthopaedic Surgery/American Council on GraduateMedical Education Residency Review Committee training requirements have necessitated the need for the adoption of simulation education into existing programmatic requirements. Current guidelines focus only on interns at a potentially significant cost to programs; both in total dollar amount and time. METHODS: The authors aim to provide a model that can maximize utility for all resident levels, manage cost by maximizing the use of cadaveric material, and allow integration of varied industry support...
2024: JB & JS Open Access
#2
JOURNAL ARTICLE
John S Kim, Yifei Sun, Pallavi Balte, Mary Cushman, Rebekah Boyle, Russell P Tracy, Linda M Styer, Taison D Bell, Michaela R Anderson, Norrina B Allen, Pamela J Schreiner, Russell P Bowler, David A Schwartz, Joyce S Lee, Vanessa Xanthakis, Margaret F Doyle, Elizabeth A Regan, Barry J Make, Alka M Kanaya, Sally E Wenzel, Josef Coresh, Carmen R Isasi, Laura M Raffield, Mitchell S V Elkind, Virginia J Howard, Victor E Ortega, Prescott Woodruff, Shelley A Cole, Joel M Henderson, Nicholas J Mantis, Monica M Parker, Ryan T Demmer, Elizabeth C Oelsner
This study investigates correlates of anti-S1 antibody response following COVID-19 vaccination in a U.S. population-based meta-cohort of adults participating in longstanding NIH-funded cohort studies. Anti-S1 antibodies were measured from dried blood spots collected between February 2021-August 2022 using Luminex-based microsphere immunoassays. Of 6245 participants, mean age was 73 years (range, 21-100), 58% were female, and 76% were non-Hispanic White. Nearly 52% of participants received the BNT162b2 vaccine and 48% received the mRNA-1273 vaccine...
February 19, 2024: Nature Communications
#3
JOURNAL ARTICLE
L Súkeníková, A Mallone, B Schreiner, P Ripellino, J Nilsson, M Stoffel, S E Ulbrich, F Sallusto, D Latorre
Guillain-Barré syndrome (GBS) is a rare heterogenous disorder of the peripheral nervous system, which is usually triggered by a preceding infection, and causes a potentially life-threatening progressive muscle weakness1 . Although GBS is considered an autoimmune disease, the mechanisms that underlie its distinct clinical subtypes remain largely unknown. Here, by combining in vitro T cell screening, single-cell RNA sequencing and T cell receptor (TCR) sequencing, we identify autoreactive memory CD4+ cells, that show a cytotoxic T helper 1 (TH 1)-like phenotype, and rare CD8+ T cells that target myelin antigens of the peripheral nerves in patients with the demyelinating disease variant...
February 2024: Nature
#4
JOURNAL ARTICLE
Sarah Schreiner, Natalie Berghaus, Alexandra M Poos, Marc S Raab, Britta Besemer, Roland Fenk, Hartmut Goldschmidt, Elias K Mai, Carsten Müller-Tidow, Niels Weinhold, Ute Hegenbart, Stefanie Huhn, Stefan O Schönland
BACKGROUND: AL amyloidosis (AL) results from the misfolding of immunoglobulin light chains (IG LCs). Aim of this study was to comprehensively analyse kappa LC sequences from AL patients in comparison with multiple myeloma (MM). OBJECTIVE: We analysed IGKV/IGKJ usage and associated organ tropism and IGKV1/D-33 in terms of mutational analysis and theoretical biochemical properties. MATERIAL AND METHODS: cDNA and bulk RNA sequencing of the LCs of AL and MM patients...
January 11, 2024: Amyloid: the International Journal of Experimental and Clinical Investigation
#5
JOURNAL ARTICLE
Lisa de Las Fuentes, Karen L Schwander, Michael R Brown, Amy R Bentley, Thomas W Winkler, Yun Ju Sung, Patricia B Munroe, Clint L Miller, Hugo Aschard, Stella Aslibekyan, Traci M Bartz, Lawrence F Bielak, Jin Fang Chai, Ching-Yu Cheng, Rajkumar Dorajoo, Mary F Feitosa, Xiuqing Guo, Fernando P Hartwig, Andrea Horimoto, Ivana Kolčić, Elise Lim, Yongmei Liu, Alisa K Manning, Jonathan Marten, Solomon K Musani, Raymond Noordam, Sandosh Padmanabhan, Tuomo Rankinen, Melissa A Richard, Paul M Ridker, Albert V Smith, Dina Vojinovic, Alan B Zonderman, Maris Alver, Mathilde Boissel, Kaare Christensen, Barry I Freedman, Chuan Gao, Franco Giulianini, Sarah E Harris, Meian He, Fang-Chi Hsu, Brigitte Kühnel, Federica Laguzzi, Xiaoyin Li, Leo-Pekka Lyytikäinen, Ilja M Nolte, Alaitz Poveda, Rainer Rauramaa, Muhammad Riaz, Antonietta Robino, Tamar Sofer, Fumihiko Takeuchi, Bamidele O Tayo, Peter J van der Most, Niek Verweij, Erin B Ware, Stefan Weiss, Wanqing Wen, Lisa R Yanek, Yiqiang Zhan, Najaf Amin, Dan E Arking, Christie Ballantyne, Eric Boerwinkle, Jennifer A Brody, Ulrich Broeckel, Archie Campbell, Mickaël Canouil, Xiaoran Chai, Yii-Der Ida Chen, Xu Chen, Kumaraswamy Naidu Chitrala, Maria Pina Concas, Ulf de Faire, Renée de Mutsert, H Janaka de Silva, Paul S de Vries, Ahn Do, Jessica D Faul, Virginia Fisher, James S Floyd, Terrence Forrester, Yechiel Friedlander, Giorgia Girotto, C Charles Gu, Göran Hallmans, Sami Heikkinen, Chew-Kiat Heng, Georg Homuth, Steven Hunt, M Arfan Ikram, David R Jacobs, Maryam Kavousi, Chiea Chuen Khor, Tuomas O Kilpeläinen, Woon-Puay Koh, Pirjo Komulainen, Carl D Langefeld, Jingjing Liang, Kiang Liu, Jianjun Liu, Kurt Lohman, Reedik Mägi, Ani W Manichaikul, Colin A McKenzie, Thomas Meitinger, Yuri Milaneschi, Matthias Nauck, Christopher P Nelson, Jeffrey R O'Connell, Nicholette D Palmer, Alexandre C Pereira, Thomas Perls, Annette Peters, Ozren Polašek, Olli T Raitakari, Kenneth Rice, Treva K Rice, Stephen S Rich, Charumathi Sabanayagam, Pamela J Schreiner, Xiao-Ou Shu, Stephen Sidney, Mario Sims, Jennifer A Smith, John M Starr, Konstantin Strauch, E Shyong Tai, Kent D Taylor, Michael Y Tsai, André G Uitterlinden, Diana van Heemst, Melanie Waldenberger, Ya-Xing Wang, Wen-Bin Wei, Gregory Wilson, Deng Xuan, Jie Yao, Caizheng Yu, Jian-Min Yuan, Wei Zhao, Diane M Becker, Amélie Bonnefond, Donald W Bowden, Richard S Cooper, Ian J Deary, Jasmin Divers, Tõnu Esko, Paul W Franks, Philippe Froguel, Christian Gieger, Jost B Jonas, Norihiro Kato, Timo A Lakka, Karin Leander, Terho Lehtimäki, Patrik K E Magnusson, Kari E North, Ioanna Ntalla, Brenda Penninx, Nilesh J Samani, Harold Snieder, Beatrice Spedicati, Pim van der Harst, Henry Völzke, Lynne E Wagenknecht, David R Weir, Mary K Wojczynski, Tangchun Wu, Wei Zheng, Xiaofeng Zhu, Claude Bouchard, Daniel I Chasman, Michele K Evans, Ervin R Fox, Vilmundur Gudnason, Caroline Hayward, Bernardo L Horta, Sharon L R Kardia, Jose Eduardo Krieger, Dennis O Mook-Kanamori, Patricia A Peyser, Michael M Province, Bruce M Psaty, Igor Rudan, Xueling Sim, Blair H Smith, Rob M van Dam, Cornelia M van Duijn, Tien Yin Wong, Donna K Arnett, Dabeeru C Rao, James Gauderman, Ching-Ti Liu, Alanna C Morrison, Jerome I Rotter, Myriam Fornage
Introduction: Educational attainment, widely used in epidemiologic studies as a surrogate for socioeconomic status, is a predictor of cardiovascular health outcomes. Methods: A two-stage genome-wide meta-analysis of low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), and triglyceride (TG) levels was performed while accounting for gene-educational attainment interactions in up to 226,315 individuals from five population groups. We considered two educational attainment variables: "Some College" (yes/no, for any education beyond high school) and "Graduated College" (yes/no, for completing a 4-year college degree)...
2023: Frontiers in Genetics
#6
JOURNAL ARTICLE
Laura M Grimm, Jeffry Setiadi, Boryslav Tkachenko, Peter R Schreiner, Michael K Gilson, Frank Biedermann
The thermodynamic parameters of host-guest binding can be used to describe, understand, and predict molecular recognition events in aqueous systems. However, interpreting binding thermodynamics remains challenging, even for these relatively simple molecules, as they are determined by both direct and solvent-mediated host-guest interactions. In this contribution, we focus on the contributions of water to binding by studying binding thermodynamics, both experimentally and computationally, for a series of nearly rigid, electrically neutral host-guest systems and report the temperature-dependent thermodynamic binding contributions Δ G b ( T ), Δ H b ( T ), Δ S b ( T ), and Δ C p,b ...
November 1, 2023: Chemical Science
#7
JOURNAL ARTICLE
M Agostini, A Alexander, G R Araujo, A M Bakalyarov, M Balata, I Barabanov, L Baudis, C Bauer, S Belogurov, A Bettini, L Bezrukov, V Biancacci, E Bossio, V Bothe, R Brugnera, A Caldwell, S Calgaro, C Cattadori, A Chernogorov, P-J Chiu, T Comellato, V D'Andrea, E V Demidova, A Di Giacinto, N Di Marco, E Doroshkevich, F Fischer, M Fomina, A Gangapshev, A Garfagnini, C Gooch, P Grabmayr, V Gurentsov, K Gusev, S Hackenmüller, S Hemmer, W Hofmann, J Huang, M Hult, L V Inzhechik, J Janicskó Csáthy, J Jochum, M Junker, V Kazalov, Y Kermaïdic, H Khushbakht, T Kihm, K Kilgus, I V Kirpichnikov, A Klimenko, K T Knöpfle, O Kochetov, V N Kornoukhov, P Krause, V V Kuzminov, M Laubenstein, B Lehnert, M Lindner, I Lippi, A Lubashevskiy, B Lubsandorzhiev, G Lutter, C Macolino, B Majorovits, W Maneschg, L Manzanillas, G Marshall, M Miloradovic, R Mingazheva, M Misiaszek, M Morella, Y Müller, I Nemchenok, M Neuberger, L Pandola, K Pelczar, L Pertoldi, P Piseri, A Pullia, C Ransom, L Rauscher, M Redchuk, S Riboldi, N Rumyantseva, C Sada, S Sailer, F Salamida, S Schönert, J Schreiner, M Schütt, A-K Schütz, O Schulz, M Schwarz, B Schwingenheuer, O Selivanenko, E Shevchik, M Shirchenko, L Shtembari, H Simgen, A Smolnikov, D Stukov, S Sullivan, A A Vasenko, A Veresnikova, C Vignoli, K von Sturm, T Wester, C Wiesinger, M Wojcik, E Yanovich, B Zatschler, I Zhitnikov, S V Zhukov, D Zinatulina, A Zschocke, A J Zsigmond, K Zuber, G Zuzel
We present the measurement of the two-neutrino double-β decay rate of ^{76}Ge performed with the GERDA Phase II experiment. With a subset of the entire GERDA exposure, 11.8 kg yr, the half-life of the process has been determined: T_{1/2}^{2ν}=(2.022±0.018_{stat}±0.038_{syst})×10^{21} yr. This is the most precise determination of the ^{76}Ge two-neutrino double-β decay half-life and one of the most precise measurements of a double-β decay process...
October 6, 2023: Physical Review Letters
#8
JOURNAL ARTICLE
M Agostini, A Alexander, G Araujo, A M Bakalyarov, M Balata, I Barabanov, L Baudis, C Bauer, S Belogurov, A Bettini, L Bezrukov, V Biancacci, E Bossio, V Bothe, R Brugnera, A Caldwell, S Calgaro, C Cattadori, A Chernogorov, P-J Chiu, T Comellato, V D'Andrea, E V Demidova, A Di Giacinto, N Di Marco, E Doroshkevich, F Fischer, M Fomina, A Gangapshev, A Garfagnini, C Gooch, P Grabmayr, V Gurentsov, K Gusev, J Hakenmüller, S Hemmer, W Hofmann, M Hult, L V Inzhechik, J Janicskó Csáthy, J Jochum, M Junker, V Kazalov, Y Kermaïdic, H Khushbakht, T Kihm, K Kilgus, I V Kirpichnikov, A Klimenko, K T Knöpfle, O Kochetov, V N Kornoukhov, P Krause, V V Kuzminov, M Laubenstein, M Lindner, I Lippi, A Lubashevskiy, B Lubsandorzhiev, G Lutter, C Macolino, B Majorovits, W Maneschg, L Manzanillas, G Marshall, M Misiaszek, M Morella, Y Müller, I Nemchenok, M Neuberger, L Pandola, K Pelczar, L Pertoldi, P Piseri, A Pullia, L Rauscher, M Redchuk, S Riboldi, N Rumyantseva, C Sada, S Sailer, F Salamida, S Schönert, J Schreiner, M Schütt, A-K Schütz, O Schulz, M Schwarz, B Schwingenheuer, O Selivanenko, E Shevchik, M Shirchenko, L Shtembari, H Simgen, A Smolnikov, D Stukov, S Sullivan, A A Vasenko, A Veresnikova, C Vignoli, K von Sturm, T Wester, C Wiesinger, M Wojcik, E Yanovich, B Zatschler, I Zhitnikov, S V Zhukov, D Zinatulina, A Zschocke, A J Zsigmond, K Zuber, G Zuzel
We search for tri-nucleon decays of <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:msup><mml:mrow/><mml:mn>76</mml:mn></mml:msup></mml:math>Ge in the dataset from the GERmanium Detector Array (GERDA) experiment. Decays that populate excited levels of the daughter nucleus above the threshold for particle emission lead to disintegration and are not considered. The ppp-, ppn-, and pnn-decays lead to <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:msup><mml:mrow/><mml:mn>73</mml:mn></mml:msup></mml:math>Cu, <mml:math xmlns:mml="https://www...
2023: European Physical Journal. C, Particles and Fields
#9
JOURNAL ARTICLE
E Aprile, K Abe, F Agostini, S Ahmed Maouloud, L Althueser, B Andrieu, E Angelino, J R Angevaare, V C Antochi, D Antón Martin, F Arneodo, L Baudis, A L Baxter, M Bazyk, L Bellagamba, R Biondi, A Bismark, E J Brookes, A Brown, S Bruenner, G Bruno, R Budnik, T K Bui, C Cai, J M R Cardoso, D Cichon, A P Cimental Chavez, A P Colijn, J Conrad, J J Cuenca-García, J P Cussonneau, V D'Andrea, M P Decowski, P Di Gangi, S Di Pede, S Diglio, K Eitel, A Elykov, S Farrell, A D Ferella, C Ferrari, H Fischer, M Flierman, W Fulgione, C Fuselli, P Gaemers, R Gaior, A Gallo Rosso, M Galloway, F Gao, R Glade-Beucke, L Grandi, J Grigat, H Guan, M Guida, R Hammann, A Higuera, C Hils, L Hoetzsch, N F Hood, J Howlett, M Iacovacci, Y Itow, J Jakob, F Joerg, A Joy, N Kato, M Kara, P Kavrigin, S Kazama, M Kobayashi, G Koltman, A Kopec, F Kuger, H Landsman, R F Lang, L Levinson, I Li, S Li, S Liang, S Lindemann, M Lindner, K Liu, J Loizeau, F Lombardi, J Long, J A M Lopes, Y Ma, C Macolino, J Mahlstedt, A Mancuso, L Manenti, F Marignetti, T Marrodán Undagoitia, K Martens, J Masbou, D Masson, E Masson, S Mastroianni, M Messina, K Miuchi, K Mizukoshi, A Molinario, S Moriyama, K Morå, Y Mosbacher, M Murra, J Müller, K Ni, U Oberlack, B Paetsch, J Palacio, R Peres, C Peters, J Pienaar, M Pierre, V Pizzella, G Plante, J Qi, J Qin, D Ramírez García, R Singh, L Sanchez, J M F Dos Santos, I Sarnoff, G Sartorelli, J Schreiner, D Schulte, P Schulte, H Schulze Eißing, M Schumann, L Scotto Lavina, M Selvi, F Semeria, P Shagin, S Shi, E Shockley, M Silva, H Simgen, A Takeda, P-L Tan, A Terliuk, D Thers, F Toschi, G Trinchero, C Tunnell, F Tönnies, K Valerius, G Volta, C Weinheimer, M Weiss, D Wenz, C Wittweg, T Wolf, V H S Wu, Y Xing, D Xu, Z Xu, M Yamashita, L Yang, J Ye, L Yuan, G Zavattini, M Zhong, T Zhu
We report on the first search for nuclear recoils from dark matter in the form of weakly interacting massive particles (WIMPs) with the XENONnT experiment, which is based on a two-phase time projection chamber with a sensitive liquid xenon mass of 5.9 ton. During the (1.09±0.03) ton yr exposure used for this search, the intrinsic ^{85}Kr and ^{222}Rn concentrations in the liquid target are reduced to unprecedentedly low levels, giving an electronic recoil background rate of (15...
July 28, 2023: Physical Review Letters
#10
JOURNAL ARTICLE
E Aprile, K Abe, S Ahmed Maouloud, L Althueser, B Andrieu, E Angelino, J R Angevaare, V C Antochi, D Antón Martin, F Arneodo, L Baudis, A L Baxter, M Bazyk, L Bellagamba, R Biondi, A Bismark, E J Brookes, A Brown, S Bruenner, G Bruno, R Budnik, T K Bui, C Cai, J M R Cardoso, D Cichon, A P Cimental Chavez, M Clark, A P Colijn, J Conrad, J J Cuenca-García, J P Cussonneau, V D'Andrea, M P Decowski, P Di Gangi, S Di Pede, S Diglio, K Eitel, A Elykov, S Farrell, A D Ferella, C Ferrari, H Fischer, M Flierman, W Fulgione, C Fuselli, P Gaemers, R Gaior, A Gallo Rosso, M Galloway, F Gao, R Glade-Beucke, L Grandi, J Grigat, H Guan, M Guida, R Hammann, A Higuera, C Hils, L Hoetzsch, N F Hood, J Howlett, M Iacovacci, Y Itow, J Jakob, F Joerg, A Joy, N Kato, M Kara, P Kavrigin, S Kazama, M Kobayashi, G Koltman, A Kopec, F Kuger, H Landsman, R F Lang, L Levinson, I Li, S Li, S Liang, S Lindemann, M Lindner, K Liu, J Loizeau, F Lombardi, J Long, J A M Lopes, Y Ma, C Macolino, J Mahlstedt, A Mancuso, L Manenti, F Marignetti, T Marrodán Undagoitia, K Martens, J Masbou, D Masson, E Masson, S Mastroianni, M Messina, K Miuchi, K Mizukoshi, A Molinario, S Moriyama, K Morå, Y Mosbacher, M Murra, J Müller, K Ni, U Oberlack, B Paetsch, J Palacio, Q Pellegrini, R Peres, C Peters, J Pienaar, M Pierre, V Pizzella, G Plante, T R Pollmann, J Qi, J Qin, D Ramírez García, R Singh, L Sanchez, J M F Dos Santos, I Sarnoff, G Sartorelli, J Schreiner, D Schulte, P Schulte, H Schulze Eißing, M Schumann, L Scotto Lavina, M Selvi, F Semeria, P Shagin, S Shi, E Shockley, M Silva, H Simgen, A Takeda, P-L Tan, A Terliuk, D Thers, F Toschi, G Trinchero, C Tunnell, F Tönnies, K Valerius, G Volta, C Weinheimer, M Weiss, D Wenz, C Wittweg, T Wolf, V H S Wu, Y Xing, D Xu, Z Xu, M Yamashita, L Yang, J Ye, L Yuan, G Zavattini, M Zhong, T Zhu
Multiple viable theoretical models predict heavy dark matter particles with a mass close to the Planck mass, a range relatively unexplored by current experimental measurements. We use 219.4 days of data collected with the XENON1T experiment to conduct a blind search for signals from multiply interacting massive particles (MIMPs). Their unique track signature allows a targeted analysis with only 0.05 expected background events from muons. Following unblinding, we observe no signal candidate events. This Letter places strong constraints on spin-independent interactions of dark matter particles with a mass between 1×10^{12} and 2×10^{17} GeV/c^{2}...
June 30, 2023: Physical Review Letters
#11
JOURNAL ARTICLE
Hanna Remde, Laura Schmidt-Pennington, Miriam Reuter, Laura-Sophie Landwehr, Marie Jensen, Harald Lahner, Otilia Kimpel, Barbara Altieri, Katharina Laubner, Jochen Schreiner, Joerg Bojunga, Stefan Kircher, Catarina Alisa Kunze, Anne Pohrt, Maria-Veronica Teleanu, Daniel Hübschmann, Albrecht Stenzinger, Hanno Glimm, Stefan Fröhling, Martin Fassnacht, Knut Mai, Matthias Kroiss
OBJECTIVE: Clinical trials with immune checkpoint inhibitors (ICI) in adrenocortical carcinoma (ACC) have yielded contradictory results. We aimed to evaluate treatment response and safety of ICI in ACC in a real-life setting. DESIGN: Retrospective cohort study of 54 patients with advanced ACC receiving ICI as compassionate use at 6 German reference centres between 2016 and 2022. METHODS: Objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS), overall survival (OS), and treatment-related adverse events (TRAE) were assessed...
June 7, 2023: European Journal of Endocrinology
#12
JOURNAL ARTICLE
M Agostini, A Alexander, G R Araujo, A M Bakalyarov, M Balata, I Barabanov, L Baudis, C Bauer, S Belogurov, A Bettini, L Bezrukov, V Biancacci, E Bossio, V Bothe, R Brugnera, A Caldwell, S Calgaro, C Cattadori, A Chernogorov, P-J Chiu, T Comellato, V D'Andrea, E V Demidova, A Di Giacinto, N Di Marco, E Doroshkevich, F Fischer, M Fomina, A Gangapshev, A Garfagnini, C Gooch, P Grabmayr, V Gurentsov, K Gusev, J Hakenmüller, S Hemmer, W Hofmann, M Hult, L V Inzhechik, J Janicskó Csáthy, J Jochum, M Junker, V Kazalov, Y Kermaïdic, H Khushbakht, T Kihm, K Kilgus, I V Kirpichnikov, A Klimenko, K T Knöpfle, O Kochetov, V N Kornoukhov, P Krause, V V Kuzminov, M Laubenstein, B Lehnert, M Lindner, I Lippi, A Lubashevskiy, B Lubsandorzhiev, G Lutter, C Macolino, B Majorovits, W Maneschg, L Manzanillas, G Marshall, M Miloradovic, R Mingazheva, M Misiaszek, M Morella, Y Müller, I Nemchenok, M Neuberger, L Pandola, K Pelczar, L Pertoldi, P Piseri, A Pullia, L Rauscher, M Redchuk, S Riboldi, N Rumyantseva, C Sada, S Sailer, F Salamida, S Schönert, J Schreiner, M Schütt, A-K Schütz, O Schulz, M Schwarz, B Schwingenheuer, O Selivanenko, E Shevchik, M Shirchenko, L Shtembari, H Simgen, A Smolnikov, D Stukov, S Sullivan, A A Vasenko, A Veresnikova, C Vignoli, K von Sturm, A Wegmann, T Wester, C Wiesinger, M Wojcik, E Yanovich, B Zatschler, I Zhitnikov, S V Zhukov, D Zinatulina, A Zschocke, A J Zsigmond, K Zuber, G Zuzel
The ability to detect liquid argon scintillation light from within a densely packed high-purity germanium detector array allowed the Gerda experiment to reach an exceptionally low background rate in the search for neutrinoless double beta decay of <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:msup><mml:mrow/> <mml:mn>76</mml:mn></mml:msup> </mml:math> Ge. Proper modeling of the light propagation throughout the experimental setup, from any origin in the liquid argon volume to its eventual detection by the novel light read-out system, provides insight into the rejection capability and is a necessary ingredient to obtain robust background predictions...
2023: European Physical Journal. C, Particles and Fields
#13
JOURNAL ARTICLE
Natalie Berghaus, Sarah Schreiner, Alexandra M Poos, Marc S Raab, Hartmut Goldschmidt, Elias K Mai, Hans-Jürgen Salwender, Helga Bernhard, Lorenz Thurner, Carsten Müller-Tidow, Niels Weinhold, Ute Hegenbart, Stefan O Schönland, Stefanie Huhn
Light chain (AL) amyloidosis is one of the most common forms of systemic amyloidosis and is caused by the deposition of insoluble fibrils derived from misfolded and aggregated immunoglobulin light chains (LC). To uncover the causes leading to this aggregation, we compared AL LC sequences with those of patients with the related disease multiple myeloma (MM), which do not aggregate in insoluble fibrils in vivo. IGLV2-14 is one of the most common AL associated IGLV-subfamilies. Here, we analyzed IGLV2-14 LC sequences of 13 AL and eight MM patients in detail...
April 25, 2023: FEBS Journal
#14
JOURNAL ARTICLE
Guilherme S Nunes, Brenda D Guterres, Anna Carolina O Machado, Anna Julia M Dangui, Rafaela A Schreiner, Inaihá Laureano Benincá, Alessandro Haupenthal
INTRODUCTION: Comprehending scientific information have been reported as a barrier in evidence-based practice (EBP) adoption. This survey research aimed to verify the preferred sources of information for acquiring knowledge about physiotherapy and the association between types of information source and barriers in EBP implementation. METHODS: A total of 610 physiotherapists were included and answered an online questionnaire about the preferred sources for searching physiotherapy-related information and possible barriers in EBP implementation...
April 12, 2023: Journal of Continuing Education in the Health Professions
#15
JOURNAL ARTICLE
Amir S Heravi, Di Zhao, Erin D Michos, Henrique Doria De Vasconcellos, Bharath Ambale-Venkatesh, Donald Lloyd-Jones, Pamela J Schreiner, Jared P Reis, James M Shikany, Cora E Lewis, Chiadi E Ndumele, Eliseo Guallar, Pamela Ouyang, Ron C Hoogeveen, Joao A C Lima, Wendy S Post, Dhananjay Vaidya
Introduction-Oxidative stress is linked to cardiovascular diseases (CVD) and is suggested to vary by sex. However, few population-level studies have explored these associations and the majority comprise populations with advanced CVD. We assessed urinary isoprostane concentrations, a standard measure of oxidative stress, in a relatively young and healthy cohort, hypothesizing that higher oxidative stress is associated with an adverse cardiometabolic profile and female sex. Methods-Oxidative stress was measured in 475 women and 266 men, aged 48-55 years, from the Coronary Artery Risk Development in Young Adults (CARDIA) study using urinary 8-isoprostane (IsoP) and 2,3-dinor-8-isoprostane (IsoP-M)...
February 23, 2023: Antioxidants (Basel, Switzerland)
#16
JOURNAL ARTICLE
Christian Koch, Juliane Fleischer, Todor Popov, Karl Frontzek, Bettina Schreiner, Patrick Roth, Markus G Manz, Simone Unseld, Antonia M S Müller, Norman F Russkamp
BACKGROUND: Immune effector cell-associated neurotoxicity syndrome (ICANS) is a common adverse event of CD19-directed chimeric antigen receptor (CAR) T cell therapy. Other neurological adverse events, however, have not methodically been described and studied. Furthermore, safety data on CAR-T cell therapy in patients with central nervous system (CNS) lymphoma remain limited. MAIN BODY: We here report occurrence of a Guillain-Barré-like syndrome (GBS) and central diabetes insipidus (cDI) following tisagenlecleucel therapy for relapsed high-grade lymphoma with CNS involvement...
January 2023: Journal for Immunotherapy of Cancer
#17
JOURNAL ARTICLE
Raffaella Pizzolato Umeton, Michael Waltz, Gregory S Aaen, Leslie Benson, Mark Gorman, Manu Goyal, Jennifer S Graves, Yolanda Harris, Lauren Krupp, Timothy E Lotze, Nikita M Shukla, Soe Mar, Jayne Ness, Mary Rensel, Teri Schreiner, Jan-Mendelt Tillema, Shelly Roalstad, Moses Rodriguez, John Rose, Emmanuelle Waubant, Bianca Weinstock-Guttman, Charles Casper, Tanuja Chitnis
BACKGROUND AND OBJECTIVE: Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune condition, which can lead to significant disability, and up to 3%-5% of the cases have a pediatric onset. There are limited studies to guide physicians in disease-modifying treatment (DMT) choices for children with NMOSD. METHODS: This retrospective cohort study evaluated children with NMOSD cases followed at 12 clinics in the US Network of Pediatric MS Centers. Cases were classified as aquaporin-4 antibody positive (AQP4+) and double seronegative (DS) when negative for AQP4+ and for myelin oligodendrocyte glycoprotein (MOG) antibody...
February 28, 2023: Neurology
#18
JOURNAL ARTICLE
E Aprile, K Abe, F Agostini, S Ahmed Maouloud, L Althueser, B Andrieu, E Angelino, J R Angevaare, V C Antochi, D Antón Martin, F Arneodo, L Baudis, A L Baxter, L Bellagamba, R Biondi, A Bismark, A Brown, S Bruenner, G Bruno, R Budnik, T K Bui, C Cai, C Capelli, J M R Cardoso, D Cichon, M Clark, A P Colijn, J Conrad, J J Cuenca-García, J P Cussonneau, V D'Andrea, M P Decowski, P Di Gangi, S Di Pede, A Di Giovanni, R Di Stefano, S Diglio, K Eitel, A Elykov, S Farrell, A D Ferella, C Ferrari, H Fischer, W Fulgione, P Gaemers, R Gaior, A Gallo Rosso, M Galloway, F Gao, R Gardner, R Glade-Beucke, L Grandi, J Grigat, M Guida, R Hammann, A Higuera, C Hils, L Hoetzsch, J Howlett, M Iacovacci, Y Itow, J Jakob, F Joerg, A Joy, N Kato, M Kara, P Kavrigin, S Kazama, M Kobayashi, G Koltman, A Kopec, F Kuger, H Landsman, R F Lang, L Levinson, I Li, S Li, S Liang, S Lindemann, M Lindner, K Liu, J Loizeau, F Lombardi, J Long, J A M Lopes, Y Ma, C Macolino, J Mahlstedt, A Mancuso, L Manenti, F Marignetti, T Marrodán Undagoitia, K Martens, J Masbou, D Masson, E Masson, S Mastroianni, M Messina, K Miuchi, K Mizukoshi, A Molinario, S Moriyama, K Morå, Y Mosbacher, M Murra, J Müller, K Ni, U Oberlack, B Paetsch, J Palacio, P Paschos, R Peres, C Peters, J Pienaar, M Pierre, V Pizzella, G Plante, J Qi, J Qin, D Ramírez García, S Reichard, A Rocchetti, N Rupp, L Sanchez, J M F Dos Santos, I Sarnoff, G Sartorelli, J Schreiner, D Schulte, P Schulte, H Schulze Eißing, M Schumann, L Scotto Lavina, M Selvi, F Semeria, P Shagin, S Shi, E Shockley, M Silva, H Simgen, J Stephen, A Takeda, P-L Tan, A Terliuk, D Thers, F Toschi, G Trinchero, C Tunnell, F Tönnies, K Valerius, G Volta, Y Wei, C Weinheimer, M Weiss, D Wenz, C Wittweg, T Wolf, D Xu, Z Xu, M Yamashita, L Yang, J Ye, L Yuan, G Zavattini, M Zhong, T Zhu
We report on a blinded analysis of low-energy electronic recoil data from the first science run of the XENONnT dark matter experiment. Novel subsystems and the increased 5.9 ton liquid xenon target reduced the background in the (1, 30) keV search region to (15.8±1.3) events/(ton×year×keV), the lowest ever achieved in a dark matter detector and ∼5 times lower than in XENON1T. With an exposure of 1.16 ton-years, we observe no excess above background and set stringent new limits on solar axions, an enhanced neutrino magnetic moment, and bosonic dark matter...
October 14, 2022: Physical Review Letters
#19
JOURNAL ARTICLE
Jaclene A Zauszniewski, John S Sweetko, Hang-Ying She, Nathanial Schreiner
BACKGROUND: Before pursuing randomized controlled trials to determine intervention effectiveness and translating interventions into clinical practice, the need for a specific intervention within a particular population must be established. This need can be determined by using established cut scores on validated measures of relevant constructs. AIM: This study examined differences on caregiver burden and resourcefulness among family caregivers of adults with various health conditions to determine their need for resourcefulness training...
October 2022: Applied Nursing Research: ANR
#20
JOURNAL ARTICLE
Nicholas C Morano, Roshelle S Smith, Victor Danelon, Ryan Schreiner, Uttsav Patel, Natalia G Herrera, Carla Smith, Steven M Olson, Michelle K Laerke, Alev Celikgil, Scott J Garforth, Sarah C Garrett-Thomson, Francis S Lee, Barbara L Hempstead, Steven C Almo
Cell surface receptors, ligands and adhesion molecules underlie development, circuit formation and synaptic function of the central nervous system and represent important therapeutic targets for many neuropathologies. The functional contributions of interactions between cell surface proteins of neurons and non-neuronal cells have not been fully addressed. Using an unbiased protein-protein interaction screen, we showed that the human immunomodulatory ligand, B7-1 (hB7-1), interacts with the p75 neurotrophin receptor (p75NTR), and that the B7-1:p75NTR interaction is a recent evolutionary adaptation present in humans and other primates, but absent in mice, rats, and other lower mammals...
September 15, 2022: Journal of Clinical Investigation
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