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https://www.readbyqxmd.com/read/27883018/cytotoxic-and-genotoxic-potential-of-food-borne-nitriles-in-a-liver-in-vitro-model
#1
Franziska Kupke, Corinna Herz, Franziska S Hanschen, Stefanie Platz, Grace A Odongo, Simone Helmig, María M Bartolomé Rodríguez, Monika Schreiner, Sascha Rohn, Evelyn Lamy
Isothiocyanates are the most intensively studied breakdown products of glucosinolates from Brassica plants and well recognized for their pleiotropic effects against cancer but also for their genotoxic potential. However, knowledge about the bioactivity of glucosinolate-borne nitriles in foods is very poor. As determined by GC-MS, broccoli glucosinolates mainly degrade to nitriles as breakdown products. The cytotoxicity of nitriles in human HepG2 cells and primary murine hepatocytes was marginal as compared to isothiocyanates...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27867202/generalization-and-fine-mapping-of-european-ancestry-based-central-adiposity-variants-in-african-ancestry-populations
#2
S Yoneyama, J Yao, X Guo, L Fernandez-Rhodes, U Lim, J Boston, P Buzková, C S Carlson, I Cheng, B Cochran, R Cooper, G Ehret, M Fornage, J Gong, M Gross, C C Gu, J Haessler, C A Haiman, B Henderson, L A Hindorff, D Houston, M R Irvin, R Jackson, L Kuller, M Leppert, C E Lewis, R Li, L Le Marchand, T C Matise, K-Dh Nguyen, A Chakravarti, J S Pankow, N Pankratz, L Pooler, M D Ritchie, S A Bien, C L Wassel, Y-DI Chen, K D Taylor, M Allison, J I Rotter, P J Schreiner, F Schumacher, L Wilkens, E Boerwinkle, C Kooperberg, U Peters, S Buyske, M Graff, K E North
BACKGROUND/OBJECTIVES: Central adiposity measures such as waist circumference (WC) and waist-to-hip ratio (WHR) are associated with cardiometabolic disorders independently of BMI and are gaining clinically utility. Several studies report genetic variants associated with central adiposity, but most utilize only European ancestry populations. Understanding whether the genetic associations discovered among mainly European descendants are shared with African ancestry populations will help elucidate the biological underpinnings of abdominal fat deposition...
November 21, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27861301/a-novel-mutation-in-slc26a4-causes-nonsyndromic-autosomal-recessive-hearing-impairment
#3
Axel Wolf, Alexandra Frohne, Matthew Allen, Thomas Parzefall, Martin Koenighofer, Markus M Schreiner, Christian Schoefer, Klemens Frei, Trevor Lucas
BACKGROUND: Heterozygous mutations in GJB2 (MIM: 121011) encoding the gap junction protein connexin 26 are overrepresented in patient groups suffering from nonsyndromic sensorineural hearing impairment (HI) implying the involvement of additional genetic factors. Mutations in SLC26A4 (MIM: 605646), encoding the protein pendrin can cause both Pendred syndrome and autosomal recessive, nonsyndromic HI locus 4 type sensorineural HI (MIM: 600791). OBJECTIVES: Aim of this study was to investigate the role of SLC26A4 coding mutations in a nonsyndromic hearing impairment (NSHI) patient group bearing heterozygous GJB2 35delG mutations...
November 17, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27768356/limits-on-active-to-sterile-neutrino-oscillations-from-disappearance-searches-in-the-minos-daya-bay-and-bugey-3-experiments
#4
P Adamson, F P An, I Anghel, A Aurisano, A B Balantekin, H R Band, G Barr, M Bishai, A Blake, S Blyth, G J Bock, D Bogert, D Cao, G F Cao, J Cao, S V Cao, T J Carroll, C M Castromonte, W R Cen, Y L Chan, J F Chang, L C Chang, Y Chang, H S Chen, Q Y Chen, R Chen, S M Chen, Y Chen, Y X Chen, J Cheng, J-H Cheng, Y P Cheng, Z K Cheng, J J Cherwinka, S Childress, M C Chu, A Chukanov, J A B Coelho, L Corwin, D Cronin-Hennessy, J P Cummings, J de Arcos, S De Rijck, Z Y Deng, A V Devan, N E Devenish, X F Ding, Y Y Ding, M V Diwan, M Dolgareva, J Dove, D A Dwyer, W R Edwards, C O Escobar, J J Evans, E Falk, G J Feldman, W Flanagan, M V Frohne, M Gabrielyan, H R Gallagher, S Germani, R Gill, R A Gomes, M Gonchar, G H Gong, H Gong, M C Goodman, P Gouffon, N Graf, R Gran, M Grassi, K Grzelak, W Q Gu, M Y Guan, L Guo, R P Guo, X H Guo, Z Guo, A Habig, R W Hackenburg, S R Hahn, R Han, S Hans, J Hartnell, R Hatcher, M He, K M Heeger, Y K Heng, A Higuera, A Holin, Y K Hor, Y B Hsiung, B Z Hu, T Hu, W Hu, E C Huang, H X Huang, J Huang, X T Huang, P Huber, W Huo, G Hussain, J Hylen, G M Irwin, Z Isvan, D E Jaffe, P Jaffke, C James, K L Jen, D Jensen, S Jetter, X L Ji, X P Ji, J B Jiao, R A Johnson, J K de Jong, J Joshi, T Kafka, L Kang, S M S Kasahara, S H Kettell, S Kohn, G Koizumi, M Kordosky, M Kramer, A Kreymer, K K Kwan, M W Kwok, T Kwok, K Lang, T J Langford, K Lau, L Lebanowski, J Lee, J H C Lee, R T Lei, R Leitner, J K C Leung, C Li, D J Li, F Li, G S Li, Q J Li, S Li, S C Li, W D Li, X N Li, Y F Li, Z B Li, H Liang, C J Lin, G L Lin, S Lin, S K Lin, Y-C Lin, J J Ling, J M Link, P J Litchfield, L Littenberg, B R Littlejohn, D W Liu, J C Liu, J L Liu, C W Loh, C Lu, H Q Lu, J S Lu, P Lucas, K B Luk, Z Lv, Q M Ma, X B Ma, X Y Ma, Y Q Ma, Y Malyshkin, W A Mann, M L Marshak, D A Martinez Caicedo, N Mayer, K T McDonald, C McGivern, R D McKeown, M M Medeiros, R Mehdiyev, J R Meier, M D Messier, W H Miller, S R Mishra, I Mitchell, M Mooney, C D Moore, L Mualem, J Musser, Y Nakajima, D Naples, J Napolitano, D Naumov, E Naumova, J K Nelson, H B Newman, H Y Ngai, R J Nichol, Z Ning, J A Nowak, J O'Connor, J P Ochoa-Ricoux, A Olshevskiy, M Orchanian, R B Pahlka, J Paley, H-R Pan, J Park, R B Patterson, S Patton, G Pawloski, V Pec, J C Peng, A Perch, M M Pfützner, D D Phan, S Phan-Budd, L Pinsky, R K Plunkett, N Poonthottathil, C S J Pun, F Z Qi, M Qi, X Qian, X Qiu, A Radovic, N Raper, B Rebel, J Ren, C Rosenfeld, R Rosero, B Roskovec, X C Ruan, H A Rubin, P Sail, M C Sanchez, J Schneps, A Schreckenberger, P Schreiner, R Sharma, S Moed Sher, A Sousa, H Steiner, G X Sun, J L Sun, N Tagg, R L Talaga, W Tang, D Taychenachev, J Thomas, M A Thomson, X Tian, A Timmons, J Todd, S C Tognini, R Toner, D Torretta, K Treskov, K V Tsang, C E Tull, G Tzanakos, J Urheim, P Vahle, N Viaux, B Viren, V Vorobel, C H Wang, M Wang, N Y Wang, R G Wang, W Wang, X Wang, Y F Wang, Z Wang, Z M Wang, R C Webb, A Weber, H Y Wei, L J Wen, K Whisnant, C White, L Whitehead, L H Whitehead, T Wise, S G Wojcicki, H L H Wong, S C F Wong, E Worcester, C-H Wu, Q Wu, W J Wu, D M Xia, J K Xia, Z Z Xing, J L Xu, J Y Xu, Y Xu, T Xue, C G Yang, H Yang, L Yang, M S Yang, M T Yang, M Ye, Z Ye, M Yeh, B L Young, Z Y Yu, S Zeng, L Zhan, C Zhang, H H Zhang, J W Zhang, Q M Zhang, X T Zhang, Y M Zhang, Y X Zhang, Z J Zhang, Z P Zhang, Z Y Zhang, J Zhao, Q W Zhao, Y B Zhao, W L Zhong, L Zhou, N Zhou, H L Zhuang, J H Zou
Searches for a light sterile neutrino have been performed independently by the MINOS and the Daya Bay experiments using the muon (anti)neutrino and electron antineutrino disappearance channels, respectively. In this Letter, results from both experiments are combined with those from the Bugey-3 reactor neutrino experiment to constrain oscillations into light sterile neutrinos. The three experiments are sensitive to complementary regions of parameter space, enabling the combined analysis to probe regions allowed by the Liquid Scintillator Neutrino Detector (LSND) and MiniBooNE experiments in a minimally extended four-neutrino flavor framework...
October 7, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27768323/search-for-sterile-neutrinos-mixing-with-muon-neutrinos-in-minos
#5
P Adamson, I Anghel, A Aurisano, G Barr, M Bishai, A Blake, G J Bock, D Bogert, S V Cao, T J Carroll, C M Castromonte, R Chen, S Childress, J A B Coelho, L Corwin, D Cronin-Hennessy, J K de Jong, S De Rijck, A V Devan, N E Devenish, M V Diwan, C O Escobar, J J Evans, E Falk, G J Feldman, W Flanagan, M V Frohne, M Gabrielyan, H R Gallagher, S Germani, R A Gomes, M C Goodman, P Gouffon, N Graf, R Gran, K Grzelak, A Habig, S R Hahn, J Hartnell, R Hatcher, A Holin, J Huang, J Hylen, G M Irwin, Z Isvan, C James, D Jensen, T Kafka, S M S Kasahara, G Koizumi, M Kordosky, A Kreymer, K Lang, J Ling, P J Litchfield, P Lucas, W A Mann, M L Marshak, N Mayer, C McGivern, M M Medeiros, R Mehdiyev, J R Meier, M D Messier, W H Miller, S R Mishra, S Moed Sher, C D Moore, L Mualem, J Musser, D Naples, J K Nelson, H B Newman, R J Nichol, J A Nowak, J O'Connor, M Orchanian, R B Pahlka, J Paley, R B Patterson, G Pawloski, A Perch, M M Pfützner, D D Phan, S Phan-Budd, R K Plunkett, N Poonthottathil, X Qiu, A Radovic, B Rebel, C Rosenfeld, H A Rubin, P Sail, M C Sanchez, J Schneps, A Schreckenberger, P Schreiner, R Sharma, A Sousa, N Tagg, R L Talaga, J Thomas, M A Thomson, X Tian, A Timmons, J Todd, S C Tognini, R Toner, D Torretta, G Tzanakos, J Urheim, P Vahle, B Viren, A Weber, R C Webb, C White, L Whitehead, L H Whitehead, S G Wojcicki, R Zwaska
We report results of a search for oscillations involving a light sterile neutrino over distances of 1.04 and 735 km in a ν_{μ}-dominated beam with a peak energy of 3 GeV. The data, from an exposure of 10.56×10^{20} protons on target, are analyzed using a phenomenological model with one sterile neutrino. We constrain the mixing parameters θ_{24} and Δm_{41}^{2} and set limits on parameters of the four-dimensional Pontecorvo-Maki-Nakagawa-Sakata matrix, |U_{μ4}|^{2} and |U_{τ4}|^{2}, under the assumption that mixing between ν_{e} and ν_{s} is negligible (|U_{e4}|^{2}=0)...
October 7, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27748454/colocalization-of-cerebral-iron-with-amyloid-beta-in-mild-cognitive-impairment
#6
J M G van Bergen, X Li, J Hua, S J Schreiner, S C Steininger, F C Quevenco, M Wyss, A F Gietl, V Treyer, S E Leh, F Buck, R M Nitsch, K P Pruessmann, P C M van Zijl, C Hock, P G Unschuld
Quantitative Susceptibility Mapping (QSM) MRI at 7 Tesla and 11-Carbon Pittsburgh-Compound-B PET were used for investigating the relationship between brain iron and Amyloid beta (Aβ) plaque-load in a context of increased risk for Alzheimer's disease (AD), as reflected by the Apolipoprotein E ε4 (APOE-e4) allele and mild cognitive impairment (MCI) in elderly subjects. Carriers of APOE-e4 with normal cognition had higher cortical Aβ-plaque-load than non-carriers. In MCI an association between APOE-e4 and higher Aβ-plaque-load was observable both for cortical and subcortical brain-regions...
October 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27686458/esicm-lives-2016-part-one-milan-italy-1-5-october-2016
#7
L Bos, L Schouten, L van Vught, M Wiewel, D Ong, O Cremer, A Artigas, I Martin-Loeches, A Hoogendijk, T van der Poll, J Horn, N Juffermans, M Schultz, N de Prost, T Pham, G Carteaux, A Mekontso Dessap, C Brun-Buisson, E Fan, G Bellani, J Laffey, A Mercat, L Brochard, B Maitre, P A Howells, D R Thickett, C Knox, D P Park, F Gao, O Tucker, T Whitehouse, D F McAuley, G D Perkins, T Pham, J Laffey, G Bellani, E Fan, L Pisani, J P Roozeman, F D Simonis, A Giangregorio, L R Schouten, S M Van der Hoeven, J Horn, A Serpa Neto, E Festic, A M Dondorp, S Grasso, L D Bos, M J Schultz, M Koster-Brouwer, D Verboom, B Scicluna, K van de Groep, J Frencken, M Schultz, T van der Poll, M Bonten, O Cremer, J I Ko, K S Kim, G J Suh, W Y Kwon, K Kim, J H Shin, O T Ranzani, E Prina, R Menendez, A Ceccato, R Mendez, C Cilloniz, A Gabarrus, M Ferrer, A Torres, A Urbano, L A Zhang, D Swigon, F Pike, R S Parker, G Clermont, C Scheer, S O Kuhn, A Modler, M Vollmer, C Fuchs, K Hahnenkamp, S Rehberg, M Gründling, A Taggu, N Darang, N Öveges, I László, K Tánczos, M Németh, G Lebák, B Tudor, D Érces, J Kaszaki, W Huber, D Trásy, Z Molnár, G Ferrara, V S Kanoore Edul, H S Canales, E Martins, C Canullán, G Murias, M O Pozo, J F Caminos Eguillor, M G Buscetti, C Ince, A Dubin, H D Aya, A Rhodes, N Fletcher, R M Grounds, M Cecconi, M Jacquet-Lagrèze, M Riche, R Schweizer, P Portran, W Fornier, M Lilot, J Neidecker, J L Fellahi, A Escoresca-Ortega, A Gutiérrez-Pizarraya, L Charris-Castro, Y Corcia-Palomo, E Fernandez-Delgado, J Garnacho-Montero, C Roger, L Muller, L Elotmani, J Lipman, J Y Lefrant, J A Roberts, R Muñoz-Bermúdez, M Samper, C Climent, F Vasco, V Sara, S Luque, N Campillo, S Grau Cerrato, J R Masclans, F Alvarez-Lerma, S Carvalho Brugger, G Jimenez Jimenez, M Miralbés Torner, J Trujillano Cabello, B Balsera Garrido, X Nuvials Casals, F Barcenilla Gaite, M Vallverdú Vidal, M Palomar Martínez, V Gusarov, D Shilkin, M Dementienko, E Nesterova, N Lashenkova, A Kuzovlev, M Zamyatin, A Demoule, S Carreira, S Lavault, O Palancca, E Morawiec, J Mayaux, I Arnulf, T Similowski, B S Rasmussen, R G Maltesen, M Hanifa, S Pedersen, S R Kristensen, R Wimmer, M Panigada, G Li Bassi, O T Ranzani, T Kolobow, A Zanella, M Cressoni, L Berra, V Parrini, H Kandil, G Salati, S Livigni, A Amatu, A Andreotti, F Tagliaferri, G Moise, G Mercurio, A Costa, A Vezzani, S Lindau, J Babel, M Cavana, D Consonni, A Pesenti, L Gattinoni, A Torres, P Mansouri, F Zand, L Zahed, F Dehghanrad, M Bahrani, M Ghorbani, B Cambiaghi, O Moerer, T Mauri, N Kunze-Szikszay, C Ritter, A Pesenti, M Quintel, L M Vilander, M A Kaunisto, S T Vaara, V Pettilä, J L G Haitsma Mulier, S Rozemeijer, A M E Spoelstra-de Man, P E Elbers, P R Tuinman, M C de Waard, H M Oudemans-van Straaten, A M A Liberatore, R B Souza, A M C R P F Martins, J C F Vieira, I H J Koh, M Galindo Martínez, R Jiménez Sánchez, L Martínez Gascón, M D Rodríguez Mulero, A Ortín Freire, A Ojados Muñoz, S Rebollo Acebes, Á Fernández Martínez, S Moreno Aliaga, L Herrera Para, J Murcia Payá, F Rodríguez Mulero, P Guerci, Y Ince, P Heeman, B Ergin, C Ince, Z Uz, M Massey, Y Ince, R Papatella, E Bulent, P Guerci, F Toraman, C Ince, E R Longbottom, H D Torrance, H C Owen, C J Hinds, R M Pearse, M J O'Dywer, Z Trogrlic, M van der Jagt, H Lingsma, H H Ponssen, J F Schoonderbeek, F Schreiner, S J Verbrugge, S Duran, T van Achterberg, J Bakker, D A M P J Gommers, E Ista, A Krajčová, P Waldauf, F Duška, A Shah, N Roy, S McKechnie, C Doree, S Fisher, S J Stanworth, J F Jensen, D Overgaard, M H Bestle, D F Christensen, I Egerod, A Pivkina, V Gusarov, I Zhivotneva, N Pasko, M Zamyatin, J F Jensen, I Egerod, M H Bestle, D F Christensen, A Alklit, R L Hansen, H Knudsen, L B Grode, D Overgaard, M Hravnak, L Chen, A Dubrawski, G Clermont, M R Pinsky, S M Parry, L D Knight, B C Connolly, C E Baldwin, Z A Puthucheary, L Denehy, N Hart, P E Morris, J Mortimore, C L Granger, H I Jensen, R Piers, B Van den Bulcke, J Malmgren, V Metaxa, A K Reyners, M Darmon, K Rusinova, D Talmor, A P Meert, L Cancelliere, L Zubek, P Maia, A Michalsen, J Decruyenaere, E Kompanje, S Vanheule, E Azoulay, S Vansteelandt, D Benoit, B Van den Bulcke, R Piers, H I Jensen, J Malmgren, V Metaxa, A K Reyners, M Darmon, K Rusinova, D Talmor, A P Meert, L Cancelliere, L Zubek, P Maia, A Michalsen, J Decruyenaere, E Kompanje, S Vanheule, E Azoulay, S Vansteelandt, D Benoit, C Ryan, D Dawson, J Ball, K Noone, B Aisling, S Prudden, A Ntantana, D Matamis, S Savvidou, M Giannakou, M Gouva, G Nakos, V Koulouras, J Aron, G Lumley, D Milliken, K Dhadwal, B A McGrath, S J Lynch, B Bovento, G Sharpe, E Grainger, S Pieri-Davies, S Wallace, B McGrath, S J Lynch, B Bovento, E Grainger, S Pieri-Davies, G Sharpe, S Wallace, M Jung, J Cho, H Park, G Suh, O Kousha, J Paddle, L Gamrin Gripenberg, M Sundström Rehal, J Wernerman, O Rooyackers, H J de Grooth, W P Choo, A M Spoelstra-de Man, E L Swart, H M Oudemans-van Straaten, L Talan, G Güven, N D Altıntas, M Padar, G Uusvel, L Starkopf, J Starkopf, A Reintam Blaser, M S Kalaiselvan, A S Arunkumar, M K Renuka, R L Shivkumar, M Volbeda, D Ten Kate, M Hoekstra, J M van der Maaten, M W Nijsten, A Komaromi, O Rooyackers, J Wernerman, Å Norberg, M Smedberg, M Mori, L Pettersson, Å Norberg, O Rooyackers, J Wernerman, M Theodorakopoulou, T Christodoulopoulou, A Diamantakis, F Frantzeskaki, M Kontogiorgi, E Chrysanthopoulou, M Lygnos, C Diakaki, A Armaganidis, K Gundogan, E Dogan, R Coskun, S Muhtaroglu, M Sungur, T Ziegler, M Guven, A Kleyman, W Khaliq, D Andreas, M Singer, R Meierhans, R Schuepbach, I De Brito-Ashurst, F Zand, G Sabetian, R Nikandish, F Hagar, M Masjedi, B Maghsudi, A Vazin, M Ghorbani, E Asadpour, K C Kao, L C Chiu, C Y Hung, C H Chang, S H Li, H C Hu, S El Maraghi, M Ali, D Rageb, M Helmy, J Marin-Corral, C Vilà, J R Masclans, A Vàzquez, I Martín-Loeches, E Díaz, J C Yébenes, A Rodriguez, F Álvarez-Lerma, N Varga, A Cortina-Gutiérrez, L Dono, M Martínez-Martínez, C Maldonado, E Papiol, M Pérez-Carrasco, R Ferrer, K Nweze, B Morton, I Welters, M Houard, B Voisin, G Ledoux, S Six, E Jaillette, S Nseir, S Romdhani, R Bouneb, D Loghmari, N Ben Aicha, J Ayachi, K Meddeb, I Chouchène, A Khedher, M Boussarsar, K S Chan, W L Yu, J Marin-Corral, C Vilà, J R Masclans, J Nolla, L Vidaur, J Bonastre, B Suberbiola, J E Guerrero, A Rodriguez, N Ramon Coll, G Jiménez Jiménez, S Carvalho Brugger, J Codina Calero, B Balsera Garrido, M García, M Palomar Martínez, M Vallverdú Vidal, M C de la Torre, E Vendrell, E Palomera, E Güell, J C Yébenes, M Serra-Prat, J F Bermejo-Martín, J Almirall, E Tomas, A Escoval, F Froe, M H Vitoria Pereira, N Velez, E Viegas, E Filipe, C Groves, M Reay, L C Chiu, H C Hu, C Y Hung, C H Chang, S H Li, K C Kao, A Ballin, F Facchin, G Sartori, F Zarantonello, E Campello, C M Radu, S Rossi, C Ori, P Simioni, N Umei, I Shingo, A C Santos, C Candeias, I Moniz, R Marçal, Z Costa E Silva, J M Ribeiro, J F Georger, J P Ponthus, M Tchir, V Amilien, M Ayoub, E Barsam, G Martucci, G Panarello, F Tuzzolino, G Capitanio, V Ferrazza, T Carollo, L Giovanni, A Arcadipane, M López Sánchez, M A González-Gay, F J Llorca Díaz, M I Rubio López, E Zogheib, L Villeret, J Nader, M Bernasinski, P Besserve, T Caus, H Dupont, P Morimont, S Habran, R Hubert, T Desaive, F Blaffart, N Janssen, J Guiot, A Pironet, P Dauby, B Lambermont, F Zarantonello, A Ballin, F Facchin, G Sartori, E Campello, T Pettenuzzo, G Citton, S Rossi, P Simioni, C Ori, C Kirakli, O Ediboglu, S Ataman, M Yarici, F Tuksavul, S Keating, A Gibson, M Gilles, M Dunn, G Price, N Young, P Remeta, P Bishop, M D Fernández Zamora, J Muñoz-Bono, E Curiel-Balsera, E Aguilar-Alonso, R Hinojosa, A Gordillo-Brenes, J A Arboleda-Sánchez, I Skorniakov, D Vikulova, C Whiteley, O Shaikh, A Jones, M Ostermann, L Forni, M Scott, J Sahatjian, W Linde-Zwirble, D Hansell, P Laoveeravat, N Srisawat, M Kongwibulwut, S Peerapornrattana, N Suwachittanont, T O Wirotwan, P Chatkaew, P Saeyub, K Latthaprecha, K Tiranathanagul, S Eiam-Ong, J A Kellum, R E Berthelsen, A Perner, A E K Jensen, J U Jensen, M H Bestle, D J Gebhard, J Price, C E Kennedy, A Akcan-Arikan, A M A Liberatore, R B Souza, A M C R P F Martins, J C F Vieira, Y R Kang, M N Nakamae, I H J Koh, K Hamed, M M Khaled, R Aly Soliman, M Sherif Mokhtar, G Seller-Pérez, D Arias-Verdú, E Llopar-Valdor, I De-Diós-Chacón, G Quesada-García, M E Herrera-Gutierrez, R Hafes, G Carroll, P Doherty, C Wright, I G Guerra Vera, M Ralston, M L Gemmell, A MacKay, E Black, C Wright, R I Docking, R Appleton, M R Ralston, L Gemmell, R Appleton, C Wright, R I Docking, E Black, A Mackay, S Rozemeijer, J L G Haitsma Mulier, J G Röttgering, P W G Elbers, A M E Spoelstra-de Man, P R Tuinman, M C de Waard, H M Oudemans-van Straaten, N Mejeni, J Nsiala, A Kilembe, P Akilimali, G Thomas, I Egerod, A E Andersson, A M Fagerdahl, V Knudsen, K Meddeb, A Ben Cheikh, Y Hamdaoui, J Ayachi, A Guiga, N Fraj, S Romdhani, N Sma, R Bouneb, I Chouchene, A Khedher, N Bouafia, M Boussarsar, A Amirian, B Ziaian, M Masjedi, C Fleischmann, D O Thomas-Rueddel, A Schettler, D Schwarzkopf, A Stacke, K Reinhart, E Filipe, A Escoval, A Martins, P Sousa, N Velez, E Viegas, E Tomas, G Snell, R Matsa, T T S Paary, M S Kalaiselvan, A M Cavalheiro, L L Rocha, C S Vallone, A Tonilo, M D S Lobato, D T Malheiro, G Sussumo, N M Lucino, F Zand, V D Rosenthal, M Masjedi, G Sabetian, B Maghsudi, M Ghorbani, A Sanaei Dashti, A Yousefipour, J R Goodall, M Williamson, E Tant, N Thomas, C Balci, C Gonen, E Haftacı, H Gurarda, E Karaca, B Paldusová, I Zýková, D Šímová, S Houston, L D'Antona, J Lloyd, V Garnelo-Rey, M Sosic, V Sotosek-Tokmazic, J Kuharic, I Antoncic, S Dunatov, A Sustic, C T Chong, M Sim, T Lyovarin, F M Acosta Díaz, S Narbona Galdó, M Muñoz Garach, O Moreno Romero, A M Pérez Bailón, A Carranza Pinel, M Colmenero, A Gritsan, A Gazenkampf, E Korchagin, N Dovbish, R M Lee, M P P Lim, C T Chong, B C L Lim, J J See, R Assis, F Filipe, N Lopes, L Pessoa, T Pereira, N Catorze, M S Aydogan, C 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T Öhman, E Redondo, M Hallbäck, M Wallin, F Suarez Sipman, A Oldner, C Hällsjö Sander, H Björne, L Colinas, G Hernandez, R Vicho, M Serna, R Cuena, A Canabal, A Chaari, K Abdel Hakim, M Etman, M El Bahr, A El Sakka, K Bousselmi, A Arali, V Kauts, W F Casey, O Bond, P De Santis, E Iesu, F Franchi, J L Vincent, J Creteur, S Scolletta, F S Taccone, Z Marutyan, L Hamidova, A Shakotko, V Movsisyan, I Uysupova, A Evdokimov, S Petrikov, C Gonen, E Haftacı, C Balci, F J Redondo Calvo, N Bejarano, V Baladron, R Villazala, J Redondo, D Padilla, P Villarejo, A Akcan-Arikan, C E Kennedy, M F Aguilar Arzapalo, C Gomez-Gonzalez, S Mas-Font, A Puppo-Moreno, M Herrera-Gutierrez, M Garcia-Garcia, S Aldunate-Calvo, E P Plata-Menchaca, X L Pérez-Fernández, M Estruch, A Betbese-Roig, P Cárdenas Campos, M Rojas Lora, N D Toapanta Gaibor, R S Contreras Medina, V D Gumucio Sanguino, E J Casanova, J Sabater Riera, K Kritmetapak, S Peerapornratana, P Kittiskulnam, T Dissayabutra, K Tiranathanagul, P Susantithapong, K Praditpornsilpa, K Tungsanga, S Eiam-Ong, N Srisawat, T Winkelmann, T Busch, J Meixensberger, S Bercker, E M Flores Cabeza, M Sánchez Sánchez, N Cáceres Giménez, C Gutierrez Melón, E Herrero de Lucas, P Millán Estañ, M Hernández Bernal, A Garcia de Lorenzo Y Mateos, B Ergin, P Guerci, P A C Specht, Y Ince, C Ince, M Balik, M Zakharchenko, F Los, H Brodska, C de Tymowski, P Augustin, M Desmard, P Montravers, S N Stapel, R de Boer, H M Oudemans, A Hollinger, T Schweingruber, F Jockers, M Dickenmann, M Siegemund, N Runciman, M Ralston, R Appleton, T Mauri, L Alban, C Turrini, T Sasso, T Langer, M Panigada, P Taccone, E Carlesso, C Marenghi, G Grasselli, A Pesenti, P Wibart, T Reginault, M Garcia, B Barbrel, A Benard, C Bader, F Vargas, H N Bui, G Hilbert, J M Serrano Simón, P Carmona Sánchez, F Ruiz Ferrón, M García de Acilu, J Marin, V Antonia, L Ruano, M Monica, R Ferrer, J R Masclans, O Roca, G Hong, D H Kim, Y S Kim, J S Park, Y K Jee, Z Yu Xiang, W Jia-Xing, W Xiao Dan, N Wen Long, W Yu, Z Yan, X Cheng, T Kobayashi, Y Onodera, R Akimoto, A Sugiura, H Suzuki, M Iwabuchi, M Nakane, K Kawamae, P Carmona Sanchez, M D Bautista Rodriguez, M Rodriguez Delgado, V Martínez de Pinillos Sánchez, A Mula Gómez, J M Serrano Simón, P Beuret, C Fortes, M Lauer, M Reboul, J C Chakarian, X Fabre, B Philippon-Jouve, S Devillez, M Clerc, N Rittayamai, M Sklar, M Dres, M Rauseo, C Campbell, B West, D E Tullis, L Brochard, Y Onodera, R Akimoto, H Suzuki, M Okada, M Nakane, K Kawamae, N Ahmad, M Wood, A Glossop, J Higuera Lucas, A Blandino Ortiz, D Cabestrero Alonso, R De Pablo Sánchez, L Rey González, R Costa, G Spinazzola, A Pizza, G Ferrone, M Rossi, M Antonelli, G Conti, H Ribeiro, J Alves, M Sousa, P Reis, C S Socolovsky, R P Cauley, J E Frankel, A L Beam, K O Olaniran, F K Gibbons, K B Christopher, J Pennington, P Zolfaghari, H S King, H H Y Kong, H P Shum, W W Yan, C Kaymak, N Okumus, A Sari, B Erdogdu, S Aksun, H Basar, A Ozcan, N Ozcan, D Oztuna, J A Malmgren, S Lundin, K Torén, M Eckerström, A Wallin, A C Waldenström, F C Riccio, D Pogson, A C P Antonio, A F Leivas, F Kenji, E James, P Morgan, G Carroll, L Gemmell, A MacKay, C Wright, J Ballantyne, S Jonnada, C S Gerrard, N Jones, J D Salciccioli, D C Marshall, M Komorowski, A Hartley, M C Sykes, R Goodson, J Shalhoub, J R Fernández Villanueva, R Fernández Garda, A M López Lago, E Rodríguez Ruiz, R Hernández Vaquero, C Galbán Rodríguez, E Varo Pérez, C Hilasque, I Oliva, G Sirgo, M C Martin, M Olona, M C Gilavert, M Bodí, C Ebm, G Aggarwal, S Huddart, N Quiney, M Cecconi, S M Fernandes, J Santos Silva, J Gouveia, D Silva, R Marques, H Bento, A Alvarez, Z Costa Silva, D Díaz Diaz, M Villanova Martínez, E Palencia Herrejon, A Martinez de la Gandara, G Gonzalo, M A Lopez, P Ruíz de Gopegui Miguelena, C I Bernal Matilla, P Sánchez Chueca, M D C Rodríguez Longares, R Ramos Abril, A L Ruíz Aguilar, R Garrido López de Murillas, R Fernández Fernández, P Morales Laborías, M A Díaz Castellanos, M E Morales Laborías, J Cho, J Kim, J Park, S Woo, T West, E Powell, A Rimmer, C Orford, N Jones, J Williams, C I Bernal Matilla, P Ruiz de Gopegui Miguelena, P Sánchez Chueca, R Ramos Abril, M D C Rodríguez Longares, A L Ruíz Aguilar, R Garrido López de Murillas, R S Bourne, R Shulman, M Tomlin, G H Mills, M Borthwick, W Berry, D García Huertas, F Manzano, F Villagrán-Ramírez, A Ruiz-Perea, C Rodríguez-Mejías, F Santiago-Ruiz, M Colmenero-Ruiz, C König, B Matt, A Kortgen, C S Hartog, A Wong, C Balan, G Barker, N Srisawat, S Peerapornratana, P Laoveeravat, S Tachaboon, S Eiam-Ong, J Paratz, G Kayambu, R Boots, M F Aguilar Arzapalo, R Vlasenko, E Gromova, S Loginov, M Kiselevskiy, Y Dolgikova, K B Tang, C M Chau, K N Lam, E Gil, G Y Suh, C M Park, J Park, C R Chung, C T Lee, A Chao, P Y Shih, Y F Chang, C H Lai, Y C Hsu, Y C Yeh, Y J Cheng, V Colella, N Zarrillo, M D'Amico, F Forfori, B Pezza, T Laddomada, V Beltramelli, M L Pizzaballa, A Doronzio, B Balicco, D Kiers, W van der Heijden, J Gerretsen, Q de Mast, S El Messaoudi, G Rongen, M Gomes, M Kox, P Pickkers, N P Riksen, Y Kashiwagi, M Okada, K Hayashi, Y Inagaki, S Fujita, M N Nakamae, Y R Kang, R B Souza, A M A Liberatore, I H J Koh, A Blet, M Sadoune, J Lemarié, N Bihry, R Bern, E Polidano, R Merval, J M Launay, B Lévy, J L Samuel, A Mebazaa, J Hartmann, S Harm, V Weber
No abstract text is available yet for this article.
September 2016: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27659211/the-whole-genome-sequence-of-the-mediterranean-fruit-fly-ceratitis-capitata-wiedemann-reveals-insights-into-the-biology-and-adaptive-evolution-of-a-highly-invasive-pest-species
#8
Alexie Papanicolaou, Marc F Schetelig, Peter Arensburger, Peter W Atkinson, Joshua B Benoit, Kostas Bourtzis, Pedro Castañera, John P Cavanaugh, Hsu Chao, Christopher Childers, Ingrid Curril, Huyen Dinh, HarshaVardhan Doddapaneni, Amanda Dolan, Shannon Dugan, Markus Friedrich, Giuliano Gasperi, Scott Geib, Georgios Georgakilas, Richard A Gibbs, Sarah D Giers, Ludvik M Gomulski, Miguel González-Guzmán, Ana Guillem-Amat, Yi Han, Artemis G Hatzigeorgiou, Pedro Hernández-Crespo, Daniel S T Hughes, Jeffery W Jones, Dimitra Karagkouni, Panagiota Koskinioti, Sandra L Lee, Anna R Malacrida, Mosè Manni, Kostas Mathiopoulos, Angela Meccariello, Shwetha C Murali, Terence D Murphy, Donna M Muzny, Georg Oberhofer, Félix Ortego, Maria D Paraskevopoulou, Monica Poelchau, Jiaxin Qu, Martin Reczko, Hugh M Robertson, Andrew J Rosendale, Andrew E Rosselot, Giuseppe Saccone, Marco Salvemini, Grazia Savini, Patrick Schreiner, Francesca Scolari, Paolo Siciliano, Sheina B Sim, George Tsiamis, Enric Ureña, Ioannis S Vlachos, John H Werren, Ernst A Wimmer, Kim C Worley, Antigone Zacharopoulou, Stephen Richards, Alfred M Handler
BACKGROUND: The Mediterranean fruit fly (medfly), Ceratitis capitata, is a major destructive insect pest due to its broad host range, which includes hundreds of fruits and vegetables. It exhibits a unique ability to invade and adapt to ecological niches throughout tropical and subtropical regions of the world, though medfly infestations have been prevented and controlled by the sterile insect technique (SIT) as part of integrated pest management programs (IPMs). The genetic analysis and manipulation of medfly has been subject to intensive study in an effort to improve SIT efficacy and other aspects of IPM control...
September 22, 2016: Genome Biology
https://www.readbyqxmd.com/read/27648287/association-of-mediterranean-diet-and-cardiorespiratory-fitness-with-the-development-of-pre-diabetes-and-diabetes-the-coronary-artery-risk-development-in-young-adults-cardia-study
#9
Anne E Bantle, Lisa S Chow, Lyn M Steffen, Qi Wang, John Hughes, Nefertiti H Durant, Katherine H Ingram, Jared P Reis, Pamela J Schreiner
OBJECTIVE: To better understand the association between a modified Mediterranean diet pattern in young adulthood, cardiorespiratory fitness in young adulthood, and the odds of developing pre-diabetes or diabetes by middle age. RESEARCH DESIGN AND METHODS: Participants from the Coronary Artery Risk Development in Young Adults (CARDIA) study who did not have pre-diabetes or diabetes at baseline (year 0 (Y0), ages 18-30) and who had data available at the Y0 and year 25 (Y25) visits were included in this analysis (n=3358)...
2016: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/27610113/metabolite-profiling-reveals-a-specific-response-in-tomato-to-predaceous-chrysoperla-carnea-larvae-and-herbivore-s-predator-interactions-with-the-generalist-pests-tetranychus-urticae-and-myzus-persicae
#10
Audrey Errard, Christian Ulrichs, Stefan Kühne, Inga Mewis, Narantuya Mishig, Ronald Maul, Mario Drungowski, Pia Parolin, Monika Schreiner, Susanne Baldermann
The spider mite Tetranychus urticae Koch and the aphid Myzus persicae (Sulzer) both infest a number of economically significant crops, including tomato (Solanum lycopersicum). Although used for decades to control pests, the impact of green lacewing larvae Chrysoperla carnea (Stephens) on plant biochemistry was not investigated. Here, we used profiling methods and targeted analyses to explore the impact of the predator and herbivore(s)-predator interactions on tomato biochemistry. Each pest and pest-predator combination induced a characteristic metabolite signature in the leaf and the fruit thus, the plant exhibited a systemic response...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27485934/a-social-media-peer-group-intervention-for-mothers-to-prevent-obesity-and-promote-healthy-growth-from-infancy-development-and-pilot-trial
#11
Rachel S Gruver, Chanelle T Bishop-Gilyard, Alexandra Lieberman, Marsha Gerdes, Senbagam Virudachalam, Andrew W Suh, Gurpreet K Kalra, Sheela N Magge, Justine Shults, Mark S Schreiner, Thomas J Power, Robert I Berkowitz, Alexander G Fiks
BACKGROUND: Evidence increasingly indicates that childhood obesity prevention efforts should begin as early as infancy. However, few interventions meet the needs of families whose infants are at increased obesity risk due to factors including income and maternal body mass index (BMI). Social media peer groups may offer a promising new way to provide these families with the knowledge, strategies, and support they need to adopt obesity prevention behaviors. OBJECTIVE: The aim of this study is to develop and pilot test a Facebook-based peer group intervention for mothers, designed to prevent pediatric obesity and promote health beginning in infancy...
2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27348868/disparities-in-early-transitions-to-obesity-in-contemporary-multi-ethnic-u-s-populations
#12
Christy L Avery, Katelyn M Holliday, Sujatro Chakladar, Joseph C Engeda, Shakia T Hardy, Jared P Reis, Pamela J Schreiner, Christina M Shay, Martha L Daviglus, Gerardo Heiss, Dan Yu Lin, Donglin Zeng
BACKGROUND: Few studies have examined weight transitions in contemporary multi-ethnic populations spanning early childhood through adulthood despite the ability of such research to inform obesity prevention, control, and disparities reduction. METHODS AND RESULTS: We characterized the ages at which African American, Caucasian, and Mexican American populations transitioned to overweight and obesity using contemporary and nationally representative cross-sectional National Health and Nutrition Examination Survey data (n = 21,220; aged 2-80 years)...
2016: PloS One
https://www.readbyqxmd.com/read/27181604/twenty-year-fitness-trends-in-young-adults-and-incidence-of-prediabetes-and-diabetes-the-cardia-study
#13
Lisa S Chow, Andrew O Odegaard, Tyler A Bosch, Anne E Bantle, Qi Wang, John Hughes, Mercedes Carnethon, Katherine H Ingram, Nefertiti Durant, Cora E Lewis, Justin Ryder, Christina M Shay, Aaron S Kelly, Pamela J Schreiner
AIMS/HYPOTHESIS: The prospective association between cardiorespiratory fitness (CRF) measured in young adulthood and middle age on development of prediabetes, defined as impaired fasting glucose and/or impaired glucose tolerance, or diabetes by middle age remains unknown. We hypothesised that higher fitness levels would be associated with reduced risk for developing incident prediabetes/diabetes by middle age. METHODS: Participants were from the Coronary Artery Risk Development in Young Adults (CARDIA) study who were free from prediabetes/diabetes at baseline (year 0 [Y0]: 1985-1986)...
August 2016: Diabetologia
https://www.readbyqxmd.com/read/27031578/associations-of-cortisol-testosterone-and-cortisol-sex-hormone-binding-globulin-ratios-with-atherosclerosis-in-middle-age-women
#14
Ju-Mi Lee, Laura A Colangelo, Joseph E Schwartz, Yuichiro Yano, David S Siscovick, Teresa Seeman, Pamela J Schreiner, Kiang J Liu, Donald M Lloyd-Jones, Philip Greenland
BACKGROUND AND AIMS: The cortisol/testosterone (C/T) ratio has been hypothesized to be a better predictor of atherosclerosis than cortisol alone. No study has assessed whether the C/T and C/sex hormone-binding globulin (SHBG) ratios are associated with atherosclerosis in a U.S. population sample. METHODS: This substudy included 367 women who had both cortisol from year 15 and testosterone and SHBG at year 16 of the Coronary Artery Risk Development in Young Adults study, an ongoing observational cohort in the United States...
May 2016: Atherosclerosis
https://www.readbyqxmd.com/read/26842778/new-insights-into-the-protein-aggregation-pathology-in-myotilinopathy-by-combined-proteomic-and-immunolocalization-analyses
#15
A Maerkens, M Olivé, A Schreiner, S Feldkirchner, J Schessl, J Uszkoreit, K Barkovits, A K Güttsches, V Theis, M Eisenacher, M Tegenthoff, L G Goldfarb, R Schröder, B Schoser, P F M van der Ven, D O Fürst, M Vorgerd, K Marcus, R A Kley
INTRODUCTION: Myofibrillar myopathies are characterized by progressive muscle weakness and impressive abnormal protein aggregation in muscle fibers. In about 10 % of patients, the disease is caused by mutations in the MYOT gene encoding myotilin. The aim of our study was to decipher the composition of protein deposits in myotilinopathy to get new information about aggregate pathology. RESULTS: Skeletal muscle samples from 15 myotilinopathy patients were included in the study...
2016: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/26674413/abnormal-striatal-resting-state-functional-connectivity-in-adolescents-with-obsessive-compulsive-disorder
#16
Gail A Bernstein, Bryon A Mueller, Melinda Westlund Schreiner, Sarah M Campbell, Emily K Regan, Peter M Nelson, Alaa K Houri, Susanne S Lee, Alexandra D Zagoloff, Kelvin O Lim, Essa S Yacoub, Kathryn R Cullen
Neuroimaging research has implicated abnormalities in cortico-striatal-thalamic-cortical (CSTC) circuitry in pediatric obsessive-compulsive disorder (OCD). In this study, resting-state functional magnetic resonance imaging (R-fMRI) was used to investigate functional connectivity in the CSTC circuitry in adolescents with OCD. Imaging was obtained with the Human Connectome Project (HCP) scanner using newly developed pulse sequences which allow for higher spatial and temporal resolution. Fifteen adolescents with OCD and 13 age- and gender-matched healthy controls (ages 12-19) underwent R-fMRI on the 3T HCP scanner...
January 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/26477309/sp100a-is-a-tumor-suppressor-that-activates-p53-dependent-transcription-and-counteracts-e1a-e1b-55k-mediated-transformation
#17
J Berscheminski, J Brun, T Speiseder, P Wimmer, W H Ip, M Terzic, T Dobner, S Schreiner
Human adenoviruses (HAdV) are used as a model system to investigate tumorigenic processes in mammalian cells where the viral oncoproteins E1A and E1B-55K are absolutely required for oncogenic transformation, because they simultaneously accelerate cell cycle progression and inhibit tumor suppressor proteins such as p53, although the underlying mechanism is still not understood in detail. In our present study, we provide evidence that E1B-55K binding to the PML-NB component Sp100A apparently has an essential role in regulating adenovirus-mediated transformation processes...
June 16, 2016: Oncogene
https://www.readbyqxmd.com/read/26456648/activation-and-modulation-of-recombinantly-expressed-serotonin-receptor-type-3a-by-terpenes-and-pungent-substances
#18
Paul M Ziemba, Benjamin S P Schreiner, Caroline Flegel, Robin Herbrechter, Timo D Stark, Thomas Hofmann, Hanns Hatt, Markus Werner, Günter Gisselmann
Serotonin receptor type 3 (5-HT3 receptor) is a ligand-gated ion channel that is expressed in the central nervous system (CNS) as well as in the peripheral nervous system (PNS). The receptor plays an important role in regulating peristalsis of the gastrointestinal tract and in functions such as emesis, cognition and anxiety. Therefore, a variety of pharmacologically active substances target the 5-HT3 receptor to treat chemotherapy-induced nausea and vomiting. The 5-HT3 receptors are activated, antagonized, or modulated by a wide range of chemically different substances, such as 2-methyl-serotonin, phenylbiguanide, setrones, or cannabinoids...
November 27, 2015: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/26425856/-cardiac-metastasis-of-a-recurrent-urothelial-carcinoma-of-the-bladder
#19
M Schreiner, B Schneider, S Pauls
No abstract text is available yet for this article.
December 2015: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/26384322/sex-and-race-ethnic-disparities-in-the-cross-sectional-association-between-depressive-symptoms-and-muscle-mass-the-multi-ethnic-study-of-atherosclerosis
#20
Rosemay A Remigio-Baker, Matthew A Allison, Pamela J Schreiner, Mercedes R Carnethon, Jennifer A Nettleton, Mahasin S Mujahid, Moyses Szklo, Rosa M Crum, Jeannie-Marie Leuotsakos, Manuel Franco, Nicole Jensky, Sherita Hill Golden
BACKGROUND: The cross-sectional area of total muscle mass has been reported to decrease by about 40% for those 20-60 years of age. Depressive symptoms may discourage motivation to engage in physical activity such as strength training shown to negate muscle loss. Inflammation related to depressive symptoms may also contribute to muscle atrophy. Physiological differences by sex and race/ethnicity may also modify the association between depression and muscle mass. Evidence on the relationship between depression (or depressive symptoms) and adiposity has been mounting; however, little is known about the depressive symptoms-muscle mass association...
September 18, 2015: BMC Psychiatry
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