keyword
https://read.qxmd.com/read/38537212/complete-resolution-of-locally-advanced-prostate-cancer-after-molecular-endoradiotherapy-with-177lu-psma
#1
JOURNAL ARTICLE
Mohsen Beheshti, Reza Vali, Soroush Zarehparvar Moghadam, HamidReza Amini, Masoumeh Hakiminejad, GhasemAli Divband
A 76-year-old man with castration-resistant prostate cancer underwent 68Ga-prostate-specific membrane antigen (PSMA) PET/CT for restaging. A large PSMA-avid tumor with invasion to adjacent organs was noted causing gross hematuria and symptomatic anemia. Two cycles of 177Lu-PSMA were administered, and the patient showed significant reduction of hematuria as well as declining in PSA levels. 177Lu-PSMA therapy can be a good treatment option in patients with locally invasive tumors.
March 25, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38537071/metabolic-tumor-burden-as-a-prognostic-indicator-after-neoadjuvant-chemotherapy-in-pancreatic-cancer
#2
JOURNAL ARTICLE
Woohyung Lee, Minyoung Oh, Jae Seung Kim, Minkyu Sung, Kwangpyo Hong, Bong Jun Kwak, Yejong Park, Eunsung Jun, Ki Byung Song, Dae Wook Hwang, Jae Hoon Lee, Changhoon Yoo, Kyu-Pyo Kim, Inkeun Park, Jae Ho Jeong, Heung-Moon Chang, Baek-Yeol Ryoo, Jung Bok Lee, Song Cheol Kim
BACKGROUND: There is no standardized assessment for evaluating response although neoadjuvant chemotherapy (NAT) is widely accepted for borderline resectable or locally advanced pancreatic cancer (BRPC or LAPC). This study was aimed to evaluate NAT response using positron emission tomography with 2-deoxy-2-[fluorine-18]fluoro-D-glucose (18F-FDG-PET/CT) parameters alongside carbohydrate antigen (CA) 19-9 levels. METHODS: Patients who underwent surgery after NAT for BRPC and LAPC between 2017 and 2021 were identified...
April 3, 2024: International Journal of Surgery
https://read.qxmd.com/read/38537036/characterisation-of-the-merozoite-thrombospondin-related-anonymous-protein-mtrap-of-plasmodium-berghei-as-a-transmission-blocking-antigen
#3
JOURNAL ARTICLE
Xiomara Alexandra Gaitán, Juliana Calit, Irina Dobrescu, Marisé Solórzano Ramos, Alba Marina Gimenez, Daniel Youssef Bargieri
BACKGROUND: Malaria is an infectious disease caused by protozoan parasites belonging to the genus Plasmodium. Human-to-human transmission depends on a mosquito vector; thus, the interruption of parasite transmission from humans to mosquitoes is an important approach in the fight against malaria. The parasite stages infectious to mosquitoes are the gametocytes, sexual stages that are ingested by the vector during a blood meal and transform into male and female gametes in the midgut. Immunity against sexual stage antigens expressed by gametocytes, gametes, and the zygote formed after fertilisation can interrupt the parasite sexual cycle in the mosquito...
2024: Memórias do Instituto Oswaldo Cruz
https://read.qxmd.com/read/38537007/independent-predictors-for-non-alcoholic-fatty-liver-disease-in-patients-with-treatment-na%C3%A3-ve-chronic-hepatitis-b
#4
JOURNAL ARTICLE
Gulsah Tuncer, Ceyda Geyiktepe-Guclu, Osman Faruk Bayramlar, Burcu Atasoy Bozan, Cigdem Yucel, Betul Copur, Kadir Gorkem Guclu, Mustafa Yıldırım, Gonul Sengöz, Filiz Pehlivanoglu
OBJECTIVE: There are limited data on non-alcoholic fatty liver disease in chronic hepatitis B virus infection. We aimed to determine the predictors for non-alcoholic fatty liver disease in patients with treatment-naïve chronic hepatitis B virus infection. METHODS: All consecutive treatment-naïve patients with chronic hepatitis B virus infection at the Haseki Training and Research Hospital between October 1, 2021, and September 31, 2022, were retrospectively enrolled...
2024: Revista da Associação Médica Brasileira
https://read.qxmd.com/read/38536981/relative-incidence-of-interstitial-lung-diseases-in-brazil
#5
JOURNAL ARTICLE
Simone Lobo Krupok Matias, Carlos Alberto de Castro Pereira, Maria Raquel Soares, Flávia Castro Velasco Fernandes, Maria Auxiliadora Carmo Moreira, Fernanda Maciel de Aguiar Baptista, Tarciane Aline Prata, Gediel Cordeiro Junior, Eliane Viana Mancuzo
OBJECTIVE: To assess the relative frequency of incident cases of interstitial lung diseases (ILDs) in Brazil. METHODS: This was a retrospective survey of new cases of ILD in six referral centers between January of 2013 and January of 2020. The diagnosis of ILD followed the criteria suggested by international bodies or was made through multidisciplinary discussion (MDD). The condition was characterized as unclassifiable ILD when there was no specific final diagnosis following MDD or when there was disagreement between clinical, radiological, or histological data...
2024: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://read.qxmd.com/read/38536954/immunogenicity-and-protective-capacity-of-cpg-odn-adjuvanted-alum-adsorbed-bivalent-meningococcal-outer-membrane-vesicle-vaccine
#6
JOURNAL ARTICLE
Tugce Canavar Yildirim, Yasemin Ozsurekci, Muzaffer Yildirim, Irem Evcili, Volkan Yazar, Kubra Aykac, Ulku Guler, Bekir Salih, Mayda Gursel, Ihsan Gursel
Invasive meningococcal disease (IMD) is caused by Neisseria meningitidis, with the main serogroups responsible for the disease being A, B, C, W, X, and Y. To date, several vaccines targeting N.meningitidis have been developed albeit with a short-lived protection. Given that MenW and MenB are the most common causes of IMD in Europe, Turkey, and Middle East, we aimed to develop an outer membrane vesicle (OMV) based bivalent vaccine as the heterologous antigen source. Herein, we compared the immunogenicity, and breadth of serum bactericidal assays (SBA) based protective coverage of OMV vaccine to X serotype with existing commercial meningococcal conjugate and polysaccharide (PS) vaccines in a murine model...
March 27, 2024: International Immunology
https://read.qxmd.com/read/38536935/the-gut-microbiota-posttranslationally-modifies-iga1-in-autoimmune-glomerulonephritis
#7
JOURNAL ARTICLE
Patrick J Gleeson, Nicolas Benech, Jonathan Chemouny, Eleftheria Metallinou, Laureline Berthelot, Jennifer da Silva, Julie Bex-Coudrat, Erwan Boedec, Fanny Canesi, Carine Bounaix, Willy Morelle, Maryse Moya-Nilges, John Kenny, Liam O'Mahony, Loredana Saveanu, Bertrand Arnulf, Aurélie Sannier, Eric Daugas, François Vrtovsnik, Patricia Lepage, Harry Sokol, Renato C Monteiro
Mechanisms underlying the disruption of self-tolerance in acquired autoimmunity remain unclear. Immunoglobulin A (IgA) nephropathy is an acquired autoimmune disease where deglycosylated IgA1 (IgA subclass 1) auto-antigens are recognized by IgG auto-antibodies, forming immune complexes that are deposited in the kidneys, leading to glomerulonephritis. In the intestinal microbiota of patients with IgA nephropathy, there was increased relative abundance of mucin-degrading bacteria, including Akkermansia muciniphila ...
March 27, 2024: Science Translational Medicine
https://read.qxmd.com/read/38536926/surgical-tumor-derived-nanoplatform-targets-tumor-associated-macrophage-for-personalized-postsurgical-cancer-immunotherapy
#8
JOURNAL ARTICLE
Gongxi Qiao, Shenglin Li, Xumin Pan, Ping Xie, Ruixi Peng, Xiangrong Huang, Mengyun He, Jianhui Jiang, Xia Chu
Directly activating CD8+ T cells within the tumor through antigen-presenting cells (APCs) hold promise for tumor elimination. However, M2-like tumor-associated macrophages (TAMs), the most abundant APCs in tumors, hinder CD8+ T cell activation due to inefficient antigen cross-presentation. Here, we demonstrated a personalized nanotherapeutic platform using surgical tumor-derived galactose ligand-modified cancer cell membrane (CM)-coated cysteine protease inhibitor (E64)-loaded mesoporous silica nanoparticles for postsurgical cancer immunotherapy...
March 29, 2024: Science Advances
https://read.qxmd.com/read/38536921/glutamine-antagonist-drp-104-suppresses-tumor-growth-and-enhances-response-to-checkpoint-blockade-in-keap1-mutant-lung-cancer
#9
JOURNAL ARTICLE
Ray Pillai, Sarah E LeBoeuf, Yuan Hao, Connie New, Jenna L E Blum, Ali Rashidfarrokhi, Shih Ming Huang, Christian Bahamon, Warren L Wu, Burcu Karadal-Ferrena, Alberto Herrera, Ellie Ivanova, Michael Cross, Jozef P Bossowski, Hongyu Ding, Makiko Hayashi, Sahith Rajalingam, Triantafyllia Karakousi, Volkan I Sayin, Kamal M Khanna, Kwok-Kin Wong, Robert Wild, Aristotelis Tsirigos, John T Poirier, Charles M Rudin, Shawn M Davidson, Sergei B Koralov, Thales Papagiannakopoulos
Loss-of-function mutations in KEAP1 frequently occur in lung cancer and are associated with poor prognosis and resistance to standard of care treatment, highlighting the need for the development of targeted therapies. We previously showed that KEAP1 mutant tumors consume glutamine to support the metabolic rewiring associated with NRF2-dependent antioxidant production. Here, using preclinical patient-derived xenograft models and antigenic orthotopic lung cancer models, we show that the glutamine antagonist prodrug DRP-104 impairs the growth of KEAP1 mutant tumors...
March 29, 2024: Science Advances
https://read.qxmd.com/read/38536793/comparison-of-blood-and-urine-concentrations-of-equol-by-lc%C3%A2-ms-ms-method-and-factors-associated-with-equol-production-in-466-japanese-men-and-women
#10
JOURNAL ARTICLE
Remi Yoshikata, Khin Zay Yar Myint, Junichi Taguchi
Equol is produced from daidzein by the action of gut bacteria on soy isoflavones. However, not all people can produce equol, and metabolism differs even among the producers. We aimed to examine the equol producer status in both men and women, and investigate the relationships among the serum and urinary isoflavones as well as to other biomedical parameters. In this study, we measured the equol and daidzein concentrations from the blood and urine of 292 men and 174 women aged between 22 and 88 years by liquid chromatography-tandem mass spectrometry (LC‒MS/MS)...
2024: PloS One
https://read.qxmd.com/read/38536748/defining-t-cell-receptor-repertoires-using-nanovial-based-binding-and-functional-screening
#11
JOURNAL ARTICLE
Doyeon Koo, Zhiyuan Mao, Robert Dimatteo, Miyako Noguchi, Natalie Tsubamoto, Jami McLaughlin, Wendy Tran, Sohyung Lee, Donghui Cheng, Joseph de Rutte, Giselle Burton Sojo, Owen N Witte, Dino Di Carlo
The ability to selectively bind to antigenic peptides and secrete effector molecules can define rare and low-affinity populations of cells with therapeutic potential in emerging T cell receptor (TCR) immunotherapies. We leverage cavity-containing hydrogel microparticles, called nanovials, each coated with peptide-major histocompatibility complex (pMHC) monomers to isolate antigen-reactive T cells. T cells are captured and activated by pMHCs inducing the secretion of effector molecules including IFN-γ and granzyme B that are accumulated on nanovials, allowing sorting based on both binding and function...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38536702/immune-interface-interference-vaccines-an-evolution-informed-approach-to-anti-bacterial-vaccine-design
#12
JOURNAL ARTICLE
Nicholas J Croucher
Developing protein-based vaccines against bacteria has proved much more challenging than producing similar immunisations against viruses. Currently, anti-bacterial vaccines are designed using methods based on reverse vaccinology. These identify broadly conserved, immunogenic proteins using a combination of genomic and high-throughput laboratory data. While this approach has successfully generated multiple rationally designed formulations that show promising immunogenicity in animal models, few have been licensed...
March 2024: Microbial Biotechnology
https://read.qxmd.com/read/38536635/the-acetic-acid-produced-by-lactobacillus-species-regulates-immune-function-to-alleviate-pedv-infection-in-piglets
#13
JOURNAL ARTICLE
Ming-Jie Sun, Jun Hong Xing, Qing-Song Yan, Bo-Shi Zou, Ying-Jie Wang, Tian-Ming Niu, Tong Yu, Hai-Bin Huang, Di Zhang, Shu-Min Zhang, Wu-Sheng Sun, Ruo-Nan Zou, Chun-Feng Wang, Chun-Wei Shi
Porcine epidemic diarrhea virus (PEDV) infection results in significant mortality among newborn piglets, leading to substantial economic setbacks in the pig industry. Short-chain fatty acids (SCFA), the metabolites of intestinal probiotics, play pivotal roles in modulating intestinal function, enhancing the intestinal barrier, and bolstering immune responses through diverse mechanisms. The protective potential of Lactobacillus delbrueckii, Lactobacillus johnsonii, and Lactococcus lactis was first noted when administered to PEDV-infected piglets...
March 27, 2024: Probiotics and Antimicrobial Proteins
https://read.qxmd.com/read/38536614/seropositivity-for-toxocara-spp-in-individuals-with-animal-hoarding-disorder-in-southern-brazil-an-alarm-for-public-health
#14
JOURNAL ARTICLE
Vamilton Alvares Santarém, Louise Bach Kmetiuk, Isabella Braghin Ferreira, Susana Angélica Zevallos Lescano, Roberto Teixeira de Souza Filho, Graziela Ribeiro da Cunha, Vivien Midori Morikawa, Sriveny Dangoudoubiyam, Andrea Pires Dos Santos, Alexander Welker Biondo
PURPOSE: Animal hoarding has been associated with unhealthy human, animal and environmental conditions that predispose such individuals to serious life-threatening risks such as arson, malnutrition, cruelty and zoonosis. The study aimed to evaluate the presence of anti-Toxocara spp. antibodies among individuals with animal hoarding disorder in Curitiba, Brazil. METHODS: 65 residences with register of animal hoarder behavior were visited and 11 residences were included in the study, with a total of 19 individuals consenting participation...
March 27, 2024: Acta Parasitologica
https://read.qxmd.com/read/38536612/filarial-nematodes-in-dogs-from-the-northeast-region-of-brazil
#15
JOURNAL ARTICLE
Daniely Oliveira do Nascimento Rocha, Lucia Oliveira Macedo, Jéssica Cardoso Pessoa de Oliveira, Samuel Souza Silva, Herbert Patric Kellermann Cleveland, Carlos Alberto do Nascimento Ramos, Alex Santos Marques, Leucio Câmara Alves, Gílcia Aparecida de Carvalho, Rafael Antonio Nascimento Ramos
PURPOSE: Medical and veterinary filarial nematodes are transmitted by blood-feeding vectors. In dogs, these parasites are mainly represented by nematodes in which microfilariae dwell in the blood (Dirofilaria spp. and Acanthocheilonema spp.) or skin (Cercopithifilaria spp. and Onchocerca lupi). The aim of this study was to determine the prevalence of these filarial infections in dogs residing in a touristic, heavily populated location in the northeastern region of Brazil. METHODS: Blood samples (n = 245) were assessed by a modified Knott test, followed by a qualitative ELISA test (SNAP® 4Dx® Plus, IDEXX Laboratory, Westbrook, Maine, USA) for the detection of antibodies against Anaplasma spp...
March 27, 2024: Acta Parasitologica
https://read.qxmd.com/read/38536425/integrated-pretreatment-diffusion-kurtosis-imaging-and-serum-squamous-cell-carcinoma-antigen-levels-a-biomarker-strategy-for-early-assessment-of-radiotherapy-outcomes-in-cervical-cancer
#16
JOURNAL ARTICLE
Xiang Zheng, Fangmin Shen, Wenjuan Chen, Wang Ren, Shaoliang Tang
OBJECTIVE: This study aims to explore the utility of pretreatment DKI parameters and serum SCC-Ag in evaluating the early therapeutic response of cervical cancer to radiotherapy. MATERIALS AND METHODS: A total of 33 patients diagnosed with cervical cancer, including 31 cases of cervical squamous cell carcinoma and two cases of adenosquamous carcinoma, participated in the study. All patients underwent conventional MRI and DKI scans on a 3T magnetic resonance scanner before radiotherapy and after ten sessions of radiotherapy...
March 27, 2024: Abdominal Radiology
https://read.qxmd.com/read/38536129/the-deep-learning-framework-icantcr-enables-early-cancer-detection-using-the-t-cell-receptor-repertoire-in-peripheral-blood
#17
JOURNAL ARTICLE
Yideng Cai, Meng Luo, Wenyi Yang, Chang Xu, Pingping Wang, Guangfu Xue, Xiyun Jin, Rui Cheng, Jinhao Que, Wenyang Zhou, Boran Pang, Shouping Xu, Yu Li, Qinghua Jiang, Zhaochun Xu
T cells recognize tumor antigens and initiate an anti-cancer immune response in the very early stages of tumor development, and the antigen specificity of T cells is determined by the T cell receptor (TCR). Therefore, monitoring changes in the TCR repertoire in peripheral blood may offer a strategy to detect various cancers at a relatively early stages. Here, we developed the deep learning framework iCanTCR to identify cancer patients based on the TCR repertoire. The iCanTCR framework uses TCRβ sequences from an individual as an input and outputs the predicted cancer probability...
March 27, 2024: Cancer Research
https://read.qxmd.com/read/38536094/the-real-time-analysis-of-gastric-juice-endofaster-for-detection-of-helicobacter-pylori-a-reliable-tool-in-substitution-of-histology
#18
JOURNAL ARTICLE
Maria C Conti Bellocchi, Enrico Gasparini, Serena DI Stefano, Valentina Bobba, Laura Bernardoni, Viola Fino, Stefano F Crinò, Armando Gabbrielli
BACKGROUND: EndoFaster perform gastric juice analysis providing real-time Helicobacter pylori (HP) diagnosis during esophagogastroduodenoscopy (EGD), based on ammonium level. We aimed to assess its accuracy in detecting HP infection compared to the paired histology and to establish the optimum ammonium concentration cut-off point (COP). METHODS: Consecutive adult outpatients referred for EGD were prospectively enrolled between December 2021 and March 2022. In-patients, those with surgically altered anatomy, suspected neoplasia, and bleeding were excluded...
March 26, 2024: Minerva gastroenterology
https://read.qxmd.com/read/38535814/development-of-a-rapid-and-sensitive-canary-biosensor-assay-for-the-detection-of-shiga-toxin-2-from-escherichia-coli
#19
JOURNAL ARTICLE
Christina C Tam, Yangyang Wang, Wen-Xian Du, Andrew R Flannery, Xiaohua He
Shiga-toxin-producing Escherichia coli (STEC) causes a wide spectrum of diseases including hemorrhagic colitis and hemolytic uremic syndrome (HUS). The current Food Safety Inspection Service (FSIS) testing methods for STEC use the Food and Drug Administration (FDA) Bacteriological Analytical Manual (BAM) protocol, which includes enrichment, cell plating, and genomic sequencing and takes time to complete, thus delaying diagnosis and treatment. We wanted to develop a rapid, sensitive, and potentially portable assay that can identify STEC by detecting Shiga toxin (Stx) using the CANARY (Cellular Analysis and Notification of Antigen Risks and Yields) B-cell based biosensor technology...
March 14, 2024: Toxins
https://read.qxmd.com/read/38535625/targeted-and-self-adjuvated-nanoglycovaccine-candidate-for-cancer-immunotherapy
#20
JOURNAL ARTICLE
Rui Freitas, Eduardo Ferreira, Andreia Miranda, Dylan Ferreira, Marta Relvas-Santos, Flávia Castro, Beatriz Santos, Martina Gonçalves, Sofia Quintas, Andreia Peixoto, Carlos Palmeira, André M N Silva, Lúcio Lara Santos, Maria José Oliveira, Bruno Sarmento, José Alexandre Ferreira
Advanced-stage solid primary tumors and metastases often express mucin 16 (MUC16), carrying immature glycans such as the Tn antigen, resulting in specific glycoproteoforms not found in healthy human tissues. This presents a valuable approach for designing targeted therapeutics, including cancer glycovaccines, which could potentially promote antigen recognition and foster the immune response to control disease spread and prevent relapse. In this study, we describe an adjuvant-free poly(lactic- co -glycolic acid) (PLGA)-based nanoglycoantigen delivery approach that outperforms conventional methods by eliminating the need for protein carriers while exhibiting targeted and adjuvant properties...
March 27, 2024: ACS Nano
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